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id='mega-menu-item-1041'><a target="_blank" class="mega-menu-link" href="/archive" tabindex="0">Last edition</a></li></ul></nav></div> <div style="background-image:url('https://idpfun.eu/wp-content/uploads/2024/08/IDPfun_Fotolia_140653285_XL-scaled.jpg');background-position:50% 50%;background-size:cover;" class="wp-block-group ticss-5f31ac89 tw-sm-hidden is-content-justification-center is-nowrap is-layout-flex wp-container-core-group-is-layout-5 wp-block-group-is-layout-flex has-background"> <div class="wp-block-group ticss-5230b8b5 has-background is-layout-flow wp-block-group-is-layout-flow" style="background-color:#21364abf;padding-top:var(--wp--preset--spacing--10);padding-right:0;padding-bottom:var(--wp--preset--spacing--10);padding-left:0"> <h3 class="wp-block-heading has-text-align-center has-base-color has-text-color has-link-color wp-elements-0e1a8a22c30dd2d239c3c8c172f262c3">IDPfun</h3> <h5 class="wp-block-heading has-text-align-center has-base-color has-text-color has-link-color wp-elements-73807a3ba17072281f335be9c923de52">A Horizon Europe funded Marie Sk艂odowska-Curie Staff Exchange project</h5> </div> </div> <div class="wp-block-group tw-lg-hidden tw-md-hidden is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-7 wp-block-group-is-layout-flex"> <section class="wp-block-group is-layout-flow wp-container-core-group-is-layout-6 wp-block-group-is-layout-flow" style="padding-top:var(--wp--preset--spacing--10);padding-right:0;padding-bottom:var(--wp--preset--spacing--10);padding-left:0"> <h3 class="wp-block-heading has-text-align-left">IDPfun</h3> <h5 class="wp-block-heading has-text-align-left">A Horizon Europe funded Marie Sk艂odowska-Curie staff Exchange project</h5> </section> </div> </header> <main class="wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-14 wp-block-group-is-layout-constrained" style="margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0"> <div 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novel ways to detect and characterize different IDP phenomena in their evolutionary context. <br>It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms.</p> <p><strong>Intrinsically disordered proteins</strong>, characterized by high conformational variability and interaction promiscuity, defy the classic protein structure-function paradigm. IDPs cover almost half of the residues in Eukaryotic proteomes. </p> <p><br>Growing evidence suggests that IDPs, interacting with multiple partners, are major players in cellular regulation and involved in numerous human diseases. <br>Computational methods have contributed to the identification of IDPs from sequence and recently published curated IDP databases provide a starting point. <br>However, functional knowledge for IDPs remains very limited.</p> </div></div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:30%"> <div class="wp-block-group has-border-color has-accent-2-border-color is-layout-flow wp-block-group-is-layout-flow" style="border-width:1px;border-radius:5px;padding-right:0;padding-left:0"> <div class="wp-block-group has-base-2-background-color has-background is-nowrap is-layout-flex wp-container-core-group-is-layout-8 wp-block-group-is-layout-flex" style="padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <h4 class="wp-block-heading"><a href="/events">News</a></h4> </div> <div class="wp-block-group has-base-3-background-color has-background is-layout-flow wp-block-group-is-layout-flow" style="margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <div class="wp-block-query is-layout-flow wp-block-query-is-layout-flow"> <div class="wp-block-query-no-results"> <p></p> </div></div> </div> </div> <div class="wp-block-group has-border-color has-accent-2-border-color is-layout-flow wp-block-group-is-layout-flow" style="border-width:1px;border-radius:5px;padding-right:0;padding-left:0"> <div class="wp-block-group has-base-2-background-color has-background is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-11 wp-block-group-is-layout-flex" style="padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <h5 class="wp-block-heading">Latest <br>tweets</h5> <a class="twitter-follow-button" href="https://twitter.com/idpfun" data-size="large" data-show-screen-name="false"> Follow @idpfun </a> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> </div> <div class="wp-block-group has-base-3-background-color has-background is-nowrap is-layout-flex wp-container-core-group-is-layout-12 wp-block-group-is-layout-flex" style="margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"></div> </div> </div> </div> <div style="height:4rem" aria-hidden="true" class="wp-block-spacer"></div> </main> <footer class="wp-block-template-part"> <div class="wp-block-group has-base-2-background-color has-background is-layout-flow wp-block-group-is-layout-flow" style="padding-top:0;padding-right:var(--wp--preset--spacing--10);padding-bottom:0;padding-left:var(--wp--preset--spacing--10)"> <div class="wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex" style="padding-right:0;padding-left:0"> <div class="wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:64px"> <figure class="wp-block-image size-full has-custom-border is-style-default ticss-b1859328"><img decoding="async" src="https://idpfun.eu/archive/wp-content/uploads/sites/2/2024/07/EU_logo-1.png" alt="" class="has-border-color has-accent-border-color wp-image-21" style="border-width:2px;object-fit:cover"/></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:810px"> <p class="has-system-sans-serif-font-family" style="font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.045), 0.9rem);">Funded by the European Union (Horizon Europe MSCA SE Grant N.101182949). 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