CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Winfred Williams - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="8lYCAsgWw7Sf0x7ppAX9OjJDCsmrAgIbu4kqO961tBuMt8LafjDeZXlYCTnS6i+NEnHsoLUx87HgXmTThbHC1w==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-9e8218e1301001388038e3fc3427ed00d079a4760ff7745d1ec1b2d59103170a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="winfred williams" /> <meta name="description" content="Winfred Williams: 5 Followers, 1 Following, 56 Research papers. Research interests: Chronic Disease, Insulin Resistance, and Running." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'c6391e6b7bb17d1ba2b2c548d02b359e14310ddc'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15252,"monthly_visitors":"119 million","monthly_visitor_count":119262695,"monthly_visitor_count_in_millions":119,"user_count":278602603,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1733970578000); window.Aedu.timeDifference = new Date().getTime() - 1733970578000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-0fb6fc03c471832908791ad7ddba619b6165b3ccf7ae0f65cf933f34b0b660a7.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-2eebbf16f94e23df09908fc0eb355e7d088296bc7bbbbe96567743814345fdd9.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-086d9084944b0c8a793ea96ac398b4180db6177bb674e9655034fb25e834c8b4.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/WinfredWilliams" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-7c63369d6bc1d9729936224080f1002d6f378f0ed8d4ed7c2ee00a7b16812651.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":21187,"name":"Running","url":"https://www.academia.edu/Documents/in/Running"},{"id":71343,"name":"Liver Cirrhosis","url":"https://www.academia.edu/Documents/in/Liver_Cirrhosis"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/WinfredWilliams","location":"/WinfredWilliams","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/WinfredWilliams","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-133b35bf-4997-46e7-9350-b93ce174c0c2"></div> <div id="ProfileCheckPaperUpdate-react-component-133b35bf-4997-46e7-9350-b93ce174c0c2"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Winfred Williams</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Winfred" data-follow-user-id="39490987" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="39490987"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">5</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">1</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-author</p><p class="data">1</p></div></a><a href="/WinfredWilliams/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data">52</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39490987" href="https://www.academia.edu/Documents/in/Chronic_Disease"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/WinfredWilliams","location":"/WinfredWilliams","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/WinfredWilliams","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Chronic Disease"]}" data-trace="false" data-dom-id="Pill-react-component-14d3c458-ec8b-4c46-8db8-7d3ec1bafa78"></div> <div id="Pill-react-component-14d3c458-ec8b-4c46-8db8-7d3ec1bafa78"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39490987" href="https://www.academia.edu/Documents/in/Insulin_Resistance"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Insulin Resistance"]}" data-trace="false" data-dom-id="Pill-react-component-599f7ed9-2f2d-4bf8-9c60-57d0e2b8b0a0"></div> <div id="Pill-react-component-599f7ed9-2f2d-4bf8-9c60-57d0e2b8b0a0"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39490987" href="https://www.academia.edu/Documents/in/Running"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Running"]}" data-trace="false" data-dom-id="Pill-react-component-93baa6e0-479f-4fd9-9393-e9ce361aaca5"></div> <div id="Pill-react-component-93baa6e0-479f-4fd9-9393-e9ce361aaca5"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39490987" href="https://www.academia.edu/Documents/in/Liver_Cirrhosis"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Liver Cirrhosis"]}" data-trace="false" data-dom-id="Pill-react-component-853508e9-2c90-41f1-abfe-6a5f5fc5cc23"></div> <div id="Pill-react-component-853508e9-2c90-41f1-abfe-6a5f5fc5cc23"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39490987" href="https://www.academia.edu/Documents/in/Insulin"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Insulin"]}" data-trace="false" data-dom-id="Pill-react-component-d47499fb-dac5-435e-8de7-d93b4d7cd225"></div> <div id="Pill-react-component-d47499fb-dac5-435e-8de7-d93b4d7cd225"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Winfred Williams</h3></div><div class="js-work-strip profile--work_container" data-work-id="125385834"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125385834/Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation"><img alt="Research paper thumbnail of Rapid Activation of the Alternative Pathway of Complement by Extracorporeal Membrane Oxygenation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125385834/Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation">Rapid Activation of the Alternative Pathway of Complement by Extracorporeal Membrane Oxygenation</a></div><div class="wp-workCard_item"><span>Asaio Journal</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125385834"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125385834"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125385834; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125385834]").text(description); $(".js-view-count[data-work-id=125385834]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125385834; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125385834']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125385834, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=125385834]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125385834,"title":"Rapid Activation of the Alternative Pathway of Complement by Extracorporeal Membrane Oxygenation","translated_title":"","metadata":{"abstract":"Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.","publisher":"Lippincott Williams \u0026 Wilkins","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Asaio Journal"},"translated_abstract":"Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.","internal_url":"https://www.academia.edu/125385834/Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation","translated_internal_url":"","created_at":"2024-11-08T11:50:06.585-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":2705,"name":"Complement activation","url":"https://www.academia.edu/Documents/in/Complement_activation"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":43051,"name":"Complement System","url":"https://www.academia.edu/Documents/in/Complement_System"},{"id":123802,"name":"Acute respiratory distress syndrome","url":"https://www.academia.edu/Documents/in/Acute_respiratory_distress_syndrome"},{"id":463111,"name":"Ards","url":"https://www.academia.edu/Documents/in/Ards"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":2328629,"name":"Extracorporeal Membrane Oxygenation","url":"https://www.academia.edu/Documents/in/Extracorporeal_Membrane_Oxygenation"},{"id":3647769,"name":"The Acute Respiratory Distress Syndrome (ARDS)","url":"https://www.academia.edu/Documents/in/The_Acute_Respiratory_Distress_Syndrome_ARDS_"},{"id":4055611,"name":"Fatal outcome","url":"https://www.academia.edu/Documents/in/Fatal_outcome"}],"urls":[{"id":45524105,"url":"https://doi.org/10.1097/00002480-199901000-00025"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87834419"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87834419/Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy"><img alt="Research paper thumbnail of Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy" class="work-thumbnail" src="https://attachments.academia-assets.com/91942710/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87834419/Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy">Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy</a></div><div class="wp-workCard_item"><span>Diabetes</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc70ef9b104c92f87b760f0b2bb17164" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91942710,"asset_id":87834419,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91942710/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87834419"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87834419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87834419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87834419]").text(description); $(".js-view-count[data-work-id=87834419]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87834419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87834419']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87834419, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bc70ef9b104c92f87b760f0b2bb17164" } } $('.js-work-strip[data-work-id=87834419]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87834419,"title":"Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy","translated_title":"","metadata":{"abstract":"We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...","publisher":"American Diabetes Association","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Diabetes"},"translated_abstract":"We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...","internal_url":"https://www.academia.edu/87834419/Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy","translated_internal_url":"","created_at":"2022-10-03T18:40:42.392-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":91942710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91942710/thumbnails/1.jpg","file_name":"3402313.pdf","download_url":"https://www.academia.edu/attachments/91942710/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Association_Testing_of_Previously_Report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91942710/3402313-libre.pdf?1664852908=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_Testing_of_Previously_Report.pdf\u0026Expires=1733974178\u0026Signature=aYcQBFxuTKvYESUNWU--xo39MFhTIZqd-mZr7aSNnxxiRMPH3wkAEBniwtooX3g-azxXlk3ODYqKZXMz5mrWrvOvvyr3cysXLTLdaG3MhlulDhctsWKfTva69awAoyx8wt-USPAs0lC-ds35ze5z7pxloSKk3Y9SYoo9T3yuUmpA61OBiUqPboSrCxx0kSgRy2jUDH4KipVX-ga3zz08cgb~EoVoyKKA6DHQ~iLKjBdT73j4b-m-HhgCctX2KqJ3URzElMaDgyqG4t0g9w1mMxEF4-UnYA0s5YR1ox6a9Cwj3PLK1INS4e5ea0QGa6dHZH-j5uXrhTsJxV4PvQhZJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy","translated_slug":"","page_count":9,"language":"en","content_type":"Work","summary":"We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":91942710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91942710/thumbnails/1.jpg","file_name":"3402313.pdf","download_url":"https://www.academia.edu/attachments/91942710/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Association_Testing_of_Previously_Report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91942710/3402313-libre.pdf?1664852908=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_Testing_of_Previously_Report.pdf\u0026Expires=1733974178\u0026Signature=aYcQBFxuTKvYESUNWU--xo39MFhTIZqd-mZr7aSNnxxiRMPH3wkAEBniwtooX3g-azxXlk3ODYqKZXMz5mrWrvOvvyr3cysXLTLdaG3MhlulDhctsWKfTva69awAoyx8wt-USPAs0lC-ds35ze5z7pxloSKk3Y9SYoo9T3yuUmpA61OBiUqPboSrCxx0kSgRy2jUDH4KipVX-ga3zz08cgb~EoVoyKKA6DHQ~iLKjBdT73j4b-m-HhgCctX2KqJ3URzElMaDgyqG4t0g9w1mMxEF4-UnYA0s5YR1ox6a9Cwj3PLK1INS4e5ea0QGa6dHZH-j5uXrhTsJxV4PvQhZJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4581,"name":"Diabetes","url":"https://www.academia.edu/Documents/in/Diabetes"},{"id":29842,"name":"Ireland","url":"https://www.academia.edu/Documents/in/Ireland"},{"id":46676,"name":"Finland","url":"https://www.academia.edu/Documents/in/Finland"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":4053741,"name":"Diabetic nephropathies","url":"https://www.academia.edu/Documents/in/Diabetic_nephropathies"}],"urls":[{"id":24440642,"url":"https://journals.org/diabetes/diabetes/article-pdf/61/8/2187/561137/2187.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396091"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396091/Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic"><img alt="Research paper thumbnail of Concurrent Session 26: Approaches to Tolerance in the Clinic" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396091/Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic">Concurrent Session 26: Approaches to Tolerance in the Clinic</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396091"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396091"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396091; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396091]").text(description); $(".js-view-count[data-work-id=85396091]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396091; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396091']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396091, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396091]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396091,"title":"Concurrent Session 26: Approaches to Tolerance in the Clinic","translated_title":"","metadata":{"abstract":"312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...","publication_date":{"day":null,"month":null,"year":2006,"errors":{}}},"translated_abstract":"312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...","internal_url":"https://www.academia.edu/85396091/Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic","translated_internal_url":"","created_at":"2022-08-22T16:16:28.028-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396090"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396090/Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors"><img alt="Research paper thumbnail of Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396090/Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors">Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396090"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396090"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396090; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396090]").text(description); $(".js-view-count[data-work-id=85396090]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396090; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396090']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396090, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396090]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396090,"title":"Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors","translated_title":"","metadata":{"abstract":"Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.","internal_url":"https://www.academia.edu/85396090/Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors","translated_internal_url":"","created_at":"2022-08-22T16:16:27.818-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247825,"url":"https://journals.lww.com/10.1097/TP.0000000000003511"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396089"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396089/Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond"><img alt="Research paper thumbnail of Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond" class="work-thumbnail" src="https://attachments.academia-assets.com/90106790/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396089/Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond">Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond</a></div><div class="wp-workCard_item"><span>Frontiers in Medicine</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a03b0d611a61dc7eb51b33f97ee1cb2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106790,"asset_id":85396089,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106790/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396089"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396089"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396089; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396089]").text(description); $(".js-view-count[data-work-id=85396089]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396089; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396089']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396089, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3a03b0d611a61dc7eb51b33f97ee1cb2" } } $('.js-work-strip[data-work-id=85396089]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396089,"title":"Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond","translated_title":"","metadata":{"publisher":"Frontiers Media SA","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Frontiers in Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396089/Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond","translated_internal_url":"","created_at":"2022-08-22T16:16:27.617-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106790,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106790/thumbnails/1.jpg","file_name":"fmed-07-568201.pdf","download_url":"https://www.academia.edu/attachments/90106790/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bridging_Office_Based_Care_With_the_Virt.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106790/fmed-07-568201-libre.pdf?1661211042=\u0026response-content-disposition=attachment%3B+filename%3DBridging_Office_Based_Care_With_the_Virt.pdf\u0026Expires=1733974178\u0026Signature=edz6dXS1Ku1FaLiiKo3KVhkTsoIMkkcxNprli2JKeE0sRGoJPrcF~N~U93AwwfU~d1DTJD97GLSwQ9cCG1mTO~OTDSh3QEcUyymfjC~Uwh3kDtdwrOOhgiR1v8uDLV8ocLrhzYWmsXIGZiuZK~72IBCu2ZkS6oSFw5bzrXuKtuco7oEqzLTQFNtW82oSiYfPtfEejcxXpWm2QysqzCgkm9aES0qjnuWGw2mzZyb5rAE4scLbjpqTjCLaPHdZLBPaiew0yyJPKGN3dUqrrCb3TN6a2GWylszM9oxB-R68i6Dg4cXEVM3F5NmuC2iQ6meoY1U-jXiA5WDcIgVr7dSocg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond","translated_slug":"","page_count":10,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106790,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106790/thumbnails/1.jpg","file_name":"fmed-07-568201.pdf","download_url":"https://www.academia.edu/attachments/90106790/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bridging_Office_Based_Care_With_the_Virt.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106790/fmed-07-568201-libre.pdf?1661211042=\u0026response-content-disposition=attachment%3B+filename%3DBridging_Office_Based_Care_With_the_Virt.pdf\u0026Expires=1733974178\u0026Signature=edz6dXS1Ku1FaLiiKo3KVhkTsoIMkkcxNprli2JKeE0sRGoJPrcF~N~U93AwwfU~d1DTJD97GLSwQ9cCG1mTO~OTDSh3QEcUyymfjC~Uwh3kDtdwrOOhgiR1v8uDLV8ocLrhzYWmsXIGZiuZK~72IBCu2ZkS6oSFw5bzrXuKtuco7oEqzLTQFNtW82oSiYfPtfEejcxXpWm2QysqzCgkm9aES0qjnuWGw2mzZyb5rAE4scLbjpqTjCLaPHdZLBPaiew0yyJPKGN3dUqrrCb3TN6a2GWylszM9oxB-R68i6Dg4cXEVM3F5NmuC2iQ6meoY1U-jXiA5WDcIgVr7dSocg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":1028827,"name":"Pandemic","url":"https://www.academia.edu/Documents/in/Pandemic"}],"urls":[{"id":23247824,"url":"https://www.frontiersin.org/articles/10.3389/fmed.2020.568201/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396088"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396088/Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning"><img alt="Research paper thumbnail of Immediate Administration of Antiviral Therapy after Transplantation of Hepatitis C‐infected Livers into Uninfected Recipients: Implications for Therapeutic Planning" class="work-thumbnail" src="https://attachments.academia-assets.com/90106786/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396088/Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning">Immediate Administration of Antiviral Therapy after Transplantation of Hepatitis C‐infected Livers into Uninfected Recipients: Implications for Therapeutic Planning</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients ha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor derived HCV-infection, and should be administered early in the post-transplant period. However, evidence on the safety and efficacy of an immediate DAA treatment approach, including how to manage logistical barriers surrounding timely DAA procurement, are required prior to broader use of HCV-positive donor organs. We report the results of a trial in which fourteen HCV-negative patients underwent successful liver transplantation from HCV-positive donors. Nine patients received viremic (nucleic acid testing (NAT)-positive) livers, and started a 12-week course of oral glecaprevirpibrentasvir (GP) within 5 days of transplant. Five patients received livers from HCV antibodypositive non-viremic donors and were followed using a reactive approach. Survival in NAT-positive recipients is 100% at a median follow-up of 46 weeks. An immediate treatment approach for HCV NAT-positive liver transplantation into uninfected recipients is safe and efficacious. Securing payer approval for DAAs early in the post-transplant course could enable need-based allocation of HCV-positive donor organs irrespective of candidate HCV status, while averting chronic HCV allograft infection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2d6d862ffeef5b9d9b4b3c46c4e29f6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106786,"asset_id":85396088,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106786/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396088"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396088"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396088; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396088]").text(description); $(".js-view-count[data-work-id=85396088]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396088; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396088']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396088, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2d6d862ffeef5b9d9b4b3c46c4e29f6b" } } $('.js-work-strip[data-work-id=85396088]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396088,"title":"Immediate Administration of Antiviral Therapy after Transplantation of Hepatitis C‐infected Livers into Uninfected Recipients: Implications for Therapeutic Planning","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor derived HCV-infection, and should be administered early in the post-transplant period. However, evidence on the safety and efficacy of an immediate DAA treatment approach, including how to manage logistical barriers surrounding timely DAA procurement, are required prior to broader use of HCV-positive donor organs. We report the results of a trial in which fourteen HCV-negative patients underwent successful liver transplantation from HCV-positive donors. Nine patients received viremic (nucleic acid testing (NAT)-positive) livers, and started a 12-week course of oral glecaprevirpibrentasvir (GP) within 5 days of transplant. Five patients received livers from HCV antibodypositive non-viremic donors and were followed using a reactive approach. Survival in NAT-positive recipients is 100% at a median follow-up of 46 weeks. An immediate treatment approach for HCV NAT-positive liver transplantation into uninfected recipients is safe and efficacious. Securing payer approval for DAAs early in the post-transplant course could enable need-based allocation of HCV-positive donor organs irrespective of candidate HCV status, while averting chronic HCV allograft infection.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"American Journal of Transplantation","grobid_abstract_attachment_id":90106786},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396088/Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning","translated_internal_url":"","created_at":"2022-08-22T16:16:27.414-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106786,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106786/thumbnails/1.jpg","file_name":"ajt.1576820220822-1-1lelib3.pdf","download_url":"https://www.academia.edu/attachments/90106786/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immediate_Administration_of_Antiviral_Th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106786/ajt.1576820220822-1-1lelib3-libre.pdf?1661211041=\u0026response-content-disposition=attachment%3B+filename%3DImmediate_Administration_of_Antiviral_Th.pdf\u0026Expires=1733974178\u0026Signature=HdxYJOfZp2~xcTryihhoHwArx7hu8sdfIwRFeXT91r3~jGvAJ3YL4BytOZvIhOzDcYUa3VSM7RTXef-S~xw7KveITe3H~u9-huGNDuZ35HX7-KSKEF5-iVETq~GpqU~67OE~Tpc23TIZ-M0YNHmwAJwNYIRvxXqsHre2EEqahW66FOZcLSqmiBWiL73Es1Lt8GjNTuD~r31ALp4lc~uR-kEIfaNkQVzMs2~rUJQEAHIWVuAcd5tQRrIPk6Lh-C7N1WzddgvcDBe4MBAbc7NsYupzvCQw9XV-3WZ35JkgNwoXBp4ydtTXK-XP9KiI3yonnrIhEJYJzq3189e1o-d32w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning","translated_slug":"","page_count":27,"language":"en","content_type":"Work","summary":"The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor derived HCV-infection, and should be administered early in the post-transplant period. However, evidence on the safety and efficacy of an immediate DAA treatment approach, including how to manage logistical barriers surrounding timely DAA procurement, are required prior to broader use of HCV-positive donor organs. We report the results of a trial in which fourteen HCV-negative patients underwent successful liver transplantation from HCV-positive donors. Nine patients received viremic (nucleic acid testing (NAT)-positive) livers, and started a 12-week course of oral glecaprevirpibrentasvir (GP) within 5 days of transplant. Five patients received livers from HCV antibodypositive non-viremic donors and were followed using a reactive approach. Survival in NAT-positive recipients is 100% at a median follow-up of 46 weeks. An immediate treatment approach for HCV NAT-positive liver transplantation into uninfected recipients is safe and efficacious. Securing payer approval for DAAs early in the post-transplant course could enable need-based allocation of HCV-positive donor organs irrespective of candidate HCV status, while averting chronic HCV allograft infection.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106786,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106786/thumbnails/1.jpg","file_name":"ajt.1576820220822-1-1lelib3.pdf","download_url":"https://www.academia.edu/attachments/90106786/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immediate_Administration_of_Antiviral_Th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106786/ajt.1576820220822-1-1lelib3-libre.pdf?1661211041=\u0026response-content-disposition=attachment%3B+filename%3DImmediate_Administration_of_Antiviral_Th.pdf\u0026Expires=1733974178\u0026Signature=HdxYJOfZp2~xcTryihhoHwArx7hu8sdfIwRFeXT91r3~jGvAJ3YL4BytOZvIhOzDcYUa3VSM7RTXef-S~xw7KveITe3H~u9-huGNDuZ35HX7-KSKEF5-iVETq~GpqU~67OE~Tpc23TIZ-M0YNHmwAJwNYIRvxXqsHre2EEqahW66FOZcLSqmiBWiL73Es1Lt8GjNTuD~r31ALp4lc~uR-kEIfaNkQVzMs2~rUJQEAHIWVuAcd5tQRrIPk6Lh-C7N1WzddgvcDBe4MBAbc7NsYupzvCQw9XV-3WZ35JkgNwoXBp4ydtTXK-XP9KiI3yonnrIhEJYJzq3189e1o-d32w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247823,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fajt.15768"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396087"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396087/Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure"><img alt="Research paper thumbnail of Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure" class="work-thumbnail" src="https://attachments.academia-assets.com/90106767/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396087/Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure">Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure</a></div><div class="wp-workCard_item"><span>Blood</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney tran...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="08dbc18f43f5b7e4d5f640d91ca27f56" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106767,"asset_id":85396087,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106767/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396087"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396087"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396087; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396087]").text(description); $(".js-view-count[data-work-id=85396087]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396087; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396087']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396087, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "08dbc18f43f5b7e4d5f640d91ca27f56" } } $('.js-work-strip[data-work-id=85396087]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396087,"title":"Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure","translated_title":"","metadata":{"abstract":"At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...","publisher":"American Society of Hematology","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Blood"},"translated_abstract":"At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...","internal_url":"https://www.academia.edu/85396087/Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure","translated_internal_url":"","created_at":"2022-08-22T16:16:27.201-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106767,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106767/thumbnails/1.jpg","file_name":"bloodbld2019000775.pdf","download_url":"https://www.academia.edu/attachments/90106767/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Haploidentical_hematopoietic_cell_and_ki.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106767/bloodbld2019000775-libre.pdf?1661211043=\u0026response-content-disposition=attachment%3B+filename%3DHaploidentical_hematopoietic_cell_and_ki.pdf\u0026Expires=1733974178\u0026Signature=ISqkZRvTMJxFm4wirh-o1zQ9tdnSN0kKo5YWwwM1AZ0oOTYfk7nOZLgUrUYamvFTtARrTztECFCZVTd4bEvVVp14szzXsBL0JoKBqbKFdKEH57StVUOuE9f0~952X4dB6cL9jWTkvUCxBwE46SBasK-Th58-8QH0IUPScDtRuplWoe7dRE2qAtUptSi7g-Pqv8lQn2xHvLM83R-PofCGp29rtyTT5z-am4Ovqgiblhj~7~3-S-UXtDaB0cYE4L4D1la85L5LT~-n-mtdmm6p5eiE08kXEK1FNCzqyycpr-zm5US91U20pW6QHaQTw-ASDmovC9EH9fAB0nrHDe-FbA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106767,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106767/thumbnails/1.jpg","file_name":"bloodbld2019000775.pdf","download_url":"https://www.academia.edu/attachments/90106767/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Haploidentical_hematopoietic_cell_and_ki.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106767/bloodbld2019000775-libre.pdf?1661211043=\u0026response-content-disposition=attachment%3B+filename%3DHaploidentical_hematopoietic_cell_and_ki.pdf\u0026Expires=1733974178\u0026Signature=ISqkZRvTMJxFm4wirh-o1zQ9tdnSN0kKo5YWwwM1AZ0oOTYfk7nOZLgUrUYamvFTtARrTztECFCZVTd4bEvVVp14szzXsBL0JoKBqbKFdKEH57StVUOuE9f0~952X4dB6cL9jWTkvUCxBwE46SBasK-Th58-8QH0IUPScDtRuplWoe7dRE2qAtUptSi7g-Pqv8lQn2xHvLM83R-PofCGp29rtyTT5z-am4Ovqgiblhj~7~3-S-UXtDaB0cYE4L4D1la85L5LT~-n-mtdmm6p5eiE08kXEK1FNCzqyycpr-zm5US91U20pW6QHaQTw-ASDmovC9EH9fAB0nrHDe-FbA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":90106766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106766/thumbnails/1.jpg","file_name":"bloodbld2019000775.pdf","download_url":"https://www.academia.edu/attachments/90106766/download_file","bulk_download_file_name":"Haploidentical_hematopoietic_cell_and_ki.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106766/bloodbld2019000775-libre.pdf?1661211045=\u0026response-content-disposition=attachment%3B+filename%3DHaploidentical_hematopoietic_cell_and_ki.pdf\u0026Expires=1733974178\u0026Signature=BNdvrbDZO03HWAnS2FgkA6MhoxtkeGbEFZZaiECR~2PV5zO105R59ZfDINMnULli2LgL-sDK5frqV47ROzKefvSFNPNS8ax75Kp2nspMC7KEq7eqB45W4Sf4Fe7DreGKi8OfBX5MzbPV5yzGruMV8hKJVvefpuZiWQfsAP52RrEgakSaR6sxFQhOhUGK1fdOcw98dG7cbkXSymz0JBN20BJ40Z9pw-77DLKdwN3apd9XvZLebjoXo0CxPPeby3afnhteI5N7FoRJP-AvonZvWN1cT0hRXjxO1oyHc0YPS9ZF9DiYboP7KTuWeq7Vo5loPPlHEYRsAYmkllBfMpClhg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":23247822,"url":"http://ashpublications.org/blood/article-pdf/134/2/211/1553913/bloodbld2019000775.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396086"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396086/BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience"><img alt="Research paper thumbnail of BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396086/BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience">BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience</a></div><div class="wp-workCard_item"><span>Clinical transplants</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396086"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396086"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396086; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396086]").text(description); $(".js-view-count[data-work-id=85396086]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396086; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396086']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396086, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396086]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396086,"title":"BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience","translated_title":"","metadata":{"abstract":"BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Clinical transplants"},"translated_abstract":"BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...","internal_url":"https://www.academia.edu/85396086/BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience","translated_internal_url":"","created_at":"2022-08-22T16:16:27.078-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":112992,"name":"BK virus","url":"https://www.academia.edu/Documents/in/BK_virus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396085"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/85396085/Modified_organ_support_devices"><img alt="Research paper thumbnail of Modified organ support devices" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/85396085/Modified_organ_support_devices">Modified organ support devices</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396085; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396085]").text(description); $(".js-view-count[data-work-id=85396085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396085, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396085,"title":"Modified organ support devices","translated_title":"","metadata":{"publication_date":{"day":4,"month":3,"year":2008,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396085/Modified_organ_support_devices","translated_internal_url":"","created_at":"2022-08-22T16:16:26.897-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Modified_organ_support_devices","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[],"urls":[{"id":23247821,"url":"http://www.freepatentsonline.com/7338461.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396084/Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension"><img alt="Research paper thumbnail of Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396084/Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension">Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension</a></div><div class="wp-workCard_item"><span>New England Journal of Medicine</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396084; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396084]").text(description); $(".js-view-count[data-work-id=85396084]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396084; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396084']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396084, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396084]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396084,"title":"Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"New England Journal of Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396084/Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension","translated_internal_url":"","created_at":"2022-08-22T16:16:26.776-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":1161066,"name":"New England Journalof Medicine","url":"https://www.academia.edu/Documents/in/New_England_Journalof_Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396083"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396083/Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients"><img alt="Research paper thumbnail of Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396083/Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients">Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients</a></div><div class="wp-workCard_item"><span>Progress in Transplantation</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To obtain information on menstrual patterns before and after transplantation, desire for future p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396083"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396083"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396083; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396083]").text(description); $(".js-view-count[data-work-id=85396083]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396083; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396083']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396083, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396083]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396083,"title":"Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients","translated_title":"","metadata":{"abstract":"To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.","publisher":"SAGE Publications","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Progress in Transplantation"},"translated_abstract":"To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.","internal_url":"https://www.academia.edu/85396083/Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients","translated_internal_url":"","created_at":"2022-08-22T16:16:26.637-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":16038,"name":"Menstruation","url":"https://www.academia.edu/Documents/in/Menstruation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49161,"name":"Safety","url":"https://www.academia.edu/Documents/in/Safety"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires"},{"id":478597,"name":"Reproductive behavior","url":"https://www.academia.edu/Documents/in/Reproductive_behavior"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":2592713,"name":"Premenopause","url":"https://www.academia.edu/Documents/in/Premenopause"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396081"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396081/Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization"><img alt="Research paper thumbnail of Neutrophil chemotactic factors derived from conjunctival epithelial cells: preliminary biochemical characterization" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396081/Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization">Neutrophil chemotactic factors derived from conjunctival epithelial cells: preliminary biochemical characterization</a></div><div class="wp-workCard_item"><span>The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396081"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396081"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396081; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396081]").text(description); $(".js-view-count[data-work-id=85396081]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396081; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396081']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396081, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396081]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396081,"title":"Neutrophil chemotactic factors derived from conjunctival epithelial cells: preliminary biochemical characterization","translated_title":"","metadata":{"abstract":"We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc"},"translated_abstract":"We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...","internal_url":"https://www.academia.edu/85396081/Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization","translated_internal_url":"","created_at":"2022-08-22T16:16:26.512-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28404,"name":"Conjunctiva","url":"https://www.academia.edu/Documents/in/Conjunctiva"},{"id":37447,"name":"Ultrafiltration","url":"https://www.academia.edu/Documents/in/Ultrafiltration"},{"id":170276,"name":"Chemotaxis","url":"https://www.academia.edu/Documents/in/Chemotaxis"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins"},{"id":201241,"name":"Affinity chromatography","url":"https://www.academia.edu/Documents/in/Affinity_chromatography"},{"id":203965,"name":"Ion Exchange Chromatography","url":"https://www.academia.edu/Documents/in/Ion_Exchange_Chromatography"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":295260,"name":"Neutrophils","url":"https://www.academia.edu/Documents/in/Neutrophils"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"},{"id":376494,"name":"Epithelium","url":"https://www.academia.edu/Documents/in/Epithelium"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396080"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396080/Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients"><img alt="Research paper thumbnail of Significance of Anticardiolipin Antibodies (Aca) in Renal Allograft Recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396080/Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients">Significance of Anticardiolipin Antibodies (Aca) in Renal Allograft Recipients</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396080"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396080"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396080; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396080]").text(description); $(".js-view-count[data-work-id=85396080]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396080; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396080']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396080, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396080]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396080,"title":"Significance of Anticardiolipin Antibodies (Aca) in Renal Allograft Recipients","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396080/Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients","translated_internal_url":"","created_at":"2022-08-22T16:16:26.304-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247819,"url":"http://journals.lww.com/00007890-199905150-00331"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396079"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396079/Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection"><img alt="Research paper thumbnail of Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection" class="work-thumbnail" src="https://attachments.academia-assets.com/90106787/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396079/Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection">Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efdc032abe910e3437a0dfafb4dea9c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106787,"asset_id":85396079,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106787/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396079"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396079"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396079; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396079]").text(description); $(".js-view-count[data-work-id=85396079]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396079; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396079']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396079, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "efdc032abe910e3437a0dfafb4dea9c1" } } $('.js-work-strip[data-work-id=85396079]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396079,"title":"Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection","translated_title":"","metadata":{"publisher":"Elsevier BV","ai_abstract":"This study investigates the incidence of tacrolimus (TAC)-associated posttransplant diabetes mellitus (PTDM) in renal transplant recipients, with a focus on the potential influence of hepatitis C virus (HCV) infection. By reviewing the charts of 114 renal allograft recipients who received TAC, the analysis aims to identify risk factors, including HCV status, that may contribute to the development of PTDM. Results indicate that the diabetogenic effects of TAC could be accentuated by HCV infection, particularly at higher TAC levels, suggesting that lower dosages might reduce PTDM incidence in HCV-positive recipients.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Transplantation Proceedings"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396079/Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection","translated_internal_url":"","created_at":"2022-08-22T16:16:26.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106787,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106787/thumbnails/1.jpg","file_name":"s0041-1345_2802_2903060-920220822-1-scufv4.pdf","download_url":"https://www.academia.edu/attachments/90106787/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tacrolimus_associated_posttransplant_dia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106787/s0041-1345_2802_2903060-920220822-1-scufv4-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTacrolimus_associated_posttransplant_dia.pdf\u0026Expires=1733974178\u0026Signature=JKmlWmL4W3L55XfJrUE-6Yn51vRvm5fYpEXJ-XgPEsqIn7zg-b~oKfemczeYr8Lno41yjqLL0w3-TSLBcieMA11dpCDG9WHKkmlW8x65IAYFfzW7984NhRGMVGUezqmKy2rwiE0jg3FhmqT2ZFBGzr8ToFRiOtvI~kypBjOe919uPQNeeEr3VEZmp5va82qunP6h33huwLsVSEJZYt7f3-VZsaVfv~tbaz6nreA4BMJD1AANLu2o8qSc~17YpdN3axB-kdUTfTmuQEKMqquKsWIliN1uWUPZmkDDgQfdfkpvoneHe6Tal~xWdtm1xC5LHOk31yvQ~jZdAuBiz9yJbQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection","translated_slug":"","page_count":3,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106787,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106787/thumbnails/1.jpg","file_name":"s0041-1345_2802_2903060-920220822-1-scufv4.pdf","download_url":"https://www.academia.edu/attachments/90106787/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tacrolimus_associated_posttransplant_dia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106787/s0041-1345_2802_2903060-920220822-1-scufv4-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTacrolimus_associated_posttransplant_dia.pdf\u0026Expires=1733974178\u0026Signature=JKmlWmL4W3L55XfJrUE-6Yn51vRvm5fYpEXJ-XgPEsqIn7zg-b~oKfemczeYr8Lno41yjqLL0w3-TSLBcieMA11dpCDG9WHKkmlW8x65IAYFfzW7984NhRGMVGUezqmKy2rwiE0jg3FhmqT2ZFBGzr8ToFRiOtvI~kypBjOe919uPQNeeEr3VEZmp5va82qunP6h33huwLsVSEJZYt7f3-VZsaVfv~tbaz6nreA4BMJD1AANLu2o8qSc~17YpdN3axB-kdUTfTmuQEKMqquKsWIliN1uWUPZmkDDgQfdfkpvoneHe6Tal~xWdtm1xC5LHOk31yvQ~jZdAuBiz9yJbQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":240356,"name":"Boston","url":"https://www.academia.edu/Documents/in/Boston"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396078"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396078/Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2"><img alt="Research paper thumbnail of Anticardiolipin Antibodies and Hepatic Artery Thrombosis After Liver TRANSPLANTATION1,2" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396078/Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2">Anticardiolipin Antibodies and Hepatic Artery Thrombosis After Liver TRANSPLANTATION1,2</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. V...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher&amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer &amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396078"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396078"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396078; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396078]").text(description); $(".js-view-count[data-work-id=85396078]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396078; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396078']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396078, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396078]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396078,"title":"Anticardiolipin Antibodies and Hepatic Artery Thrombosis After Liver TRANSPLANTATION1,2","translated_title":"","metadata":{"abstract":"Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher\u0026amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer \u0026amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher\u0026amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer \u0026amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.","internal_url":"https://www.academia.edu/85396078/Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2","translated_internal_url":"","created_at":"2022-08-22T16:16:25.966-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher\u0026amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer \u0026amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2892963,"name":"immunoglobulin M","url":"https://www.academia.edu/Documents/in/immunoglobulin_M"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247818,"url":"http://journals.lww.com/00007890-199711150-00021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396077/Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation"><img alt="Research paper thumbnail of Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/90106788/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396077/Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation">Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fa1a4f3797f0deff84b6fb55d30cde38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106788,"asset_id":85396077,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106788/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396077]").text(description); $(".js-view-count[data-work-id=85396077]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396077']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396077, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fa1a4f3797f0deff84b6fb55d30cde38" } } $('.js-work-strip[data-work-id=85396077]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396077,"title":"Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","ai_abstract":"The paper discusses the case of a 45-year-old male liver transplant recipient with hepatitis C virus (HCV)-associated complications, specifically nephrotic syndrome due to mixed cryoglobulinemic glomerulonephritis. Following the onset of renal dysfunction, a combination therapy of interferon alfa-2b and ribavirin was administered, leading to a significant reduction in HCV RNA levels and normalization of renal function. The findings emphasize the potential efficacy of antiviral therapy post-liver transplantation in managing renal manifestations associated with HCV infection.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396077/Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation","translated_internal_url":"","created_at":"2022-08-22T16:16:25.752-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106788,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106788/thumbnails/1.jpg","file_name":"00007890-200212270-0002120220822-1-17xc10n.pdf","download_url":"https://www.academia.edu/attachments/90106788/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Remission_of_hepatitis_C_virus_associate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106788/00007890-200212270-0002120220822-1-17xc10n-libre.pdf?1661211039=\u0026response-content-disposition=attachment%3B+filename%3DRemission_of_hepatitis_C_virus_associate.pdf\u0026Expires=1733974178\u0026Signature=LMR~VD6VXz9SSDNswCZr2ICN6cIo0H6euK7ULENgf2DhzRBFfjgKEmasjhyjsmOIcnR7NHGpddJk913kq8mUCv8cvmL6RuSjsqTnWyiL3PUZYkisj-Kcpo3LbG~SZMTII6WLTcGGEf9qR4wAn-5DfTz3pAgcFaOlFilB0cqGxEqAUKcMtxNhqtfsH7g9LNSabdOHDXVsaEDtuRTdrZsWF70lAt71zheVUvTzXJRV5i3jya28M8sRL4P47Tym-pJaSoa0m17pUj-xAUL1SSX5AH6vjsRmB7s5V8Dzuolok61DKTjqh~9gztsXqswyz-cPhKFshMu~YgWqq3ZQbFcrVw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation","translated_slug":"","page_count":2,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106788,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106788/thumbnails/1.jpg","file_name":"00007890-200212270-0002120220822-1-17xc10n.pdf","download_url":"https://www.academia.edu/attachments/90106788/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Remission_of_hepatitis_C_virus_associate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106788/00007890-200212270-0002120220822-1-17xc10n-libre.pdf?1661211039=\u0026response-content-disposition=attachment%3B+filename%3DRemission_of_hepatitis_C_virus_associate.pdf\u0026Expires=1733974178\u0026Signature=LMR~VD6VXz9SSDNswCZr2ICN6cIo0H6euK7ULENgf2DhzRBFfjgKEmasjhyjsmOIcnR7NHGpddJk913kq8mUCv8cvmL6RuSjsqTnWyiL3PUZYkisj-Kcpo3LbG~SZMTII6WLTcGGEf9qR4wAn-5DfTz3pAgcFaOlFilB0cqGxEqAUKcMtxNhqtfsH7g9LNSabdOHDXVsaEDtuRTdrZsWF70lAt71zheVUvTzXJRV5i3jya28M8sRL4P47Tym-pJaSoa0m17pUj-xAUL1SSX5AH6vjsRmB7s5V8Dzuolok61DKTjqh~9gztsXqswyz-cPhKFshMu~YgWqq3ZQbFcrVw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins"},{"id":1457700,"name":"Ribavirin","url":"https://www.academia.edu/Documents/in/Ribavirin"},{"id":1601249,"name":"Glomerulonephritis","url":"https://www.academia.edu/Documents/in/Glomerulonephritis"},{"id":1622318,"name":"Antiviral Agents","url":"https://www.academia.edu/Documents/in/Antiviral_Agents"},{"id":2028055,"name":"Interferon Alpha","url":"https://www.academia.edu/Documents/in/Interferon_Alpha"},{"id":2425458,"name":"Cryoglobulinemia","url":"https://www.academia.edu/Documents/in/Cryoglobulinemia"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247817,"url":"http://journals.lww.com/00007890-200212270-00021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396076"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396076/Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1"><img alt="Research paper thumbnail of Renal Disease Associated with Hepatitis C Infection After Kidney and Liver TRANSPLANTATION1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396076/Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1">Renal Disease Associated with Hepatitis C Infection After Kidney and Liver TRANSPLANTATION1</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Win...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396076"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396076"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396076; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396076]").text(description); $(".js-view-count[data-work-id=85396076]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396076; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396076']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396076, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396076]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396076,"title":"Renal Disease Associated with Hepatitis C Infection After Kidney and Liver TRANSPLANTATION1","translated_title":"","metadata":{"abstract":"... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...","internal_url":"https://www.academia.edu/85396076/Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1","translated_internal_url":"","created_at":"2022-08-22T16:16:25.564-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":1180098,"name":"Renal disease","url":"https://www.academia.edu/Documents/in/Renal_disease"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247816,"url":"http://journals.lww.com/00007890-200007270-00001"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396075"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396075/Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1"><img alt="Research paper thumbnail of Nephrotic Syndrome After Liver Transplantation in a Patient with Hepatitis C Virus-Associated GLOMERULONEPHRITIS1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396075/Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1">Nephrotic Syndrome After Liver Transplantation in a Patient with Hepatitis C Virus-Associated GLOMERULONEPHRITIS1</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In recent years, hepatitis C virus infection has been reported to be typically associated with me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396075"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396075]").text(description); $(".js-view-count[data-work-id=85396075]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396075']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396075, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396075]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396075,"title":"Nephrotic Syndrome After Liver Transplantation in a Patient with Hepatitis C Virus-Associated GLOMERULONEPHRITIS1","translated_title":"","metadata":{"abstract":"In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.","internal_url":"https://www.academia.edu/85396075/Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1","translated_internal_url":"","created_at":"2022-08-22T16:16:25.432-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":63890,"name":"Complication","url":"https://www.academia.edu/Documents/in/Complication"},{"id":71284,"name":"Enalapril","url":"https://www.academia.edu/Documents/in/Enalapril"},{"id":140320,"name":"Hepatitis C Virus","url":"https://www.academia.edu/Documents/in/Hepatitis_C_Virus"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":777616,"name":"Proteinuria","url":"https://www.academia.edu/Documents/in/Proteinuria"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":1601249,"name":"Glomerulonephritis","url":"https://www.academia.edu/Documents/in/Glomerulonephritis"},{"id":1773304,"name":"Nephrotic syndrome","url":"https://www.academia.edu/Documents/in/Nephrotic_syndrome"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation"},{"id":2717373,"name":"Hepacivirus","url":"https://www.academia.edu/Documents/in/Hepacivirus"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396074"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396074/Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation"><img alt="Research paper thumbnail of Treatment of Refractory Acute Humoral Rejection in Kidney Transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/90106785/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396074/Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation">Treatment of Refractory Acute Humoral Rejection in Kidney Transplantation</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="066ccf15c8b1ab51993d21b135886e3a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106785,"asset_id":85396074,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106785/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396074"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396074"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396074; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396074]").text(description); $(".js-view-count[data-work-id=85396074]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396074; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396074']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396074, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "066ccf15c8b1ab51993d21b135886e3a" } } $('.js-work-strip[data-work-id=85396074]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396074,"title":"Treatment of Refractory Acute Humoral Rejection in Kidney Transplantation","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396074/Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation","translated_internal_url":"","created_at":"2022-08-22T16:16:25.241-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106785,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106785/thumbnails/1.jpg","file_name":"00007890-200004271-0067220220822-1-1wpzx5k.pdf","download_url":"https://www.academia.edu/attachments/90106785/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_Refractory_Acute_Humoral_Re.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106785/00007890-200004271-0067220220822-1-1wpzx5k-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_Refractory_Acute_Humoral_Re.pdf\u0026Expires=1733974178\u0026Signature=D1Kpj0t7zuM6hzF-4n~8JArVXci0RhwNtKxcQ4CNYzYBPzccDnBWYoVnUbPft6Vmfi96Rv3g1nq1qzlPcro10MJ53W~zsyzWT~HHnKNjCASXzDrWqh1srgW4NXU1HInnpIxgJL1dwlDDGE-SsXfvLJvQjukGlN0TFXNaCzzm9O4j3meSzUinoW0o91Or2SJgfTuZljWMfyJsm81hrI2bdi2NfMeH~CNqmHOLjhagK3KdqVASD9Q8GGqmM5ZG1v-ZVffSy5gZv3vT0uTlNpXws2sN34gZGoyjDjXLGXIQ9oiAmAfklmp3Q1p96jfbq7OJRiiqLst7wL1DjxoEfVKpWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106785,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106785/thumbnails/1.jpg","file_name":"00007890-200004271-0067220220822-1-1wpzx5k.pdf","download_url":"https://www.academia.edu/attachments/90106785/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_Refractory_Acute_Humoral_Re.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106785/00007890-200004271-0067220220822-1-1wpzx5k-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_Refractory_Acute_Humoral_Re.pdf\u0026Expires=1733974178\u0026Signature=D1Kpj0t7zuM6hzF-4n~8JArVXci0RhwNtKxcQ4CNYzYBPzccDnBWYoVnUbPft6Vmfi96Rv3g1nq1qzlPcro10MJ53W~zsyzWT~HHnKNjCASXzDrWqh1srgW4NXU1HInnpIxgJL1dwlDDGE-SsXfvLJvQjukGlN0TFXNaCzzm9O4j3meSzUinoW0o91Or2SJgfTuZljWMfyJsm81hrI2bdi2NfMeH~CNqmHOLjhagK3KdqVASD9Q8GGqmM5ZG1v-ZVffSy5gZv3vT0uTlNpXws2sN34gZGoyjDjXLGXIQ9oiAmAfklmp3Q1p96jfbq7OJRiiqLst7wL1DjxoEfVKpWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247815,"url":"http://journals.lww.com/00007890-200004271-00672"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396073"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396073/Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1"><img alt="Research paper thumbnail of Plasma Exchange and Tacrolimus-Mycophenolate Rescue for Acute Humoral Rejection in Kidney TRANSPLANTATION1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396073/Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1">Plasma Exchange and Tacrolimus-Mycophenolate Rescue for Acute Humoral Rejection in Kidney TRANSPLANTATION1</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute renal allograft rejection associated with the development of donor-specific alloantibody (a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient&amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396073"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396073"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396073; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396073]").text(description); $(".js-view-count[data-work-id=85396073]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396073; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396073']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396073, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396073]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396073,"title":"Plasma Exchange and Tacrolimus-Mycophenolate Rescue for Acute Humoral Rejection in Kidney TRANSPLANTATION1","translated_title":"","metadata":{"abstract":"Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient\u0026amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient\u0026amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.","internal_url":"https://www.academia.edu/85396073/Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1","translated_internal_url":"","created_at":"2022-08-22T16:16:25.045-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient\u0026amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":2963614,"name":" Mycophenolic Acid","url":"https://www.academia.edu/Documents/in/Mycophenolic_Acid"},{"id":3718527,"name":"Plasma exchange","url":"https://www.academia.edu/Documents/in/Plasma_exchange"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247814,"url":"http://journals.lww.com/00007890-199812150-00008"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4191212" id="papers"><div class="js-work-strip profile--work_container" data-work-id="125385834"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125385834/Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation"><img alt="Research paper thumbnail of Rapid Activation of the Alternative Pathway of Complement by Extracorporeal Membrane Oxygenation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125385834/Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation">Rapid Activation of the Alternative Pathway of Complement by Extracorporeal Membrane Oxygenation</a></div><div class="wp-workCard_item"><span>Asaio Journal</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125385834"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125385834"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125385834; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125385834]").text(description); $(".js-view-count[data-work-id=125385834]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125385834; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125385834']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125385834, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=125385834]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125385834,"title":"Rapid Activation of the Alternative Pathway of Complement by Extracorporeal Membrane Oxygenation","translated_title":"","metadata":{"abstract":"Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.","publisher":"Lippincott Williams \u0026 Wilkins","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Asaio Journal"},"translated_abstract":"Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.","internal_url":"https://www.academia.edu/125385834/Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation","translated_internal_url":"","created_at":"2024-11-08T11:50:06.585-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Rapid_Activation_of_the_Alternative_Pathway_of_Complement_by_Extracorporeal_Membrane_Oxygenation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":2705,"name":"Complement activation","url":"https://www.academia.edu/Documents/in/Complement_activation"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":43051,"name":"Complement System","url":"https://www.academia.edu/Documents/in/Complement_System"},{"id":123802,"name":"Acute respiratory distress syndrome","url":"https://www.academia.edu/Documents/in/Acute_respiratory_distress_syndrome"},{"id":463111,"name":"Ards","url":"https://www.academia.edu/Documents/in/Ards"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":2328629,"name":"Extracorporeal Membrane Oxygenation","url":"https://www.academia.edu/Documents/in/Extracorporeal_Membrane_Oxygenation"},{"id":3647769,"name":"The Acute Respiratory Distress Syndrome (ARDS)","url":"https://www.academia.edu/Documents/in/The_Acute_Respiratory_Distress_Syndrome_ARDS_"},{"id":4055611,"name":"Fatal outcome","url":"https://www.academia.edu/Documents/in/Fatal_outcome"}],"urls":[{"id":45524105,"url":"https://doi.org/10.1097/00002480-199901000-00025"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87834419"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87834419/Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy"><img alt="Research paper thumbnail of Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy" class="work-thumbnail" src="https://attachments.academia-assets.com/91942710/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87834419/Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy">Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy</a></div><div class="wp-workCard_item"><span>Diabetes</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc70ef9b104c92f87b760f0b2bb17164" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91942710,"asset_id":87834419,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91942710/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87834419"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87834419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87834419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87834419]").text(description); $(".js-view-count[data-work-id=87834419]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87834419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87834419']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87834419, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bc70ef9b104c92f87b760f0b2bb17164" } } $('.js-work-strip[data-work-id=87834419]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87834419,"title":"Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy","translated_title":"","metadata":{"abstract":"We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...","publisher":"American Diabetes Association","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Diabetes"},"translated_abstract":"We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...","internal_url":"https://www.academia.edu/87834419/Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy","translated_internal_url":"","created_at":"2022-10-03T18:40:42.392-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":91942710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91942710/thumbnails/1.jpg","file_name":"3402313.pdf","download_url":"https://www.academia.edu/attachments/91942710/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Association_Testing_of_Previously_Report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91942710/3402313-libre.pdf?1664852908=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_Testing_of_Previously_Report.pdf\u0026Expires=1733974178\u0026Signature=aYcQBFxuTKvYESUNWU--xo39MFhTIZqd-mZr7aSNnxxiRMPH3wkAEBniwtooX3g-azxXlk3ODYqKZXMz5mrWrvOvvyr3cysXLTLdaG3MhlulDhctsWKfTva69awAoyx8wt-USPAs0lC-ds35ze5z7pxloSKk3Y9SYoo9T3yuUmpA61OBiUqPboSrCxx0kSgRy2jUDH4KipVX-ga3zz08cgb~EoVoyKKA6DHQ~iLKjBdT73j4b-m-HhgCctX2KqJ3URzElMaDgyqG4t0g9w1mMxEF4-UnYA0s5YR1ox6a9Cwj3PLK1INS4e5ea0QGa6dHZH-j5uXrhTsJxV4PvQhZJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Association_Testing_of_Previously_Reported_Variants_in_a_Large_Case_Control_Meta_analysis_of_Diabetic_Nephropathy","translated_slug":"","page_count":9,"language":"en","content_type":"Work","summary":"We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P =...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":91942710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91942710/thumbnails/1.jpg","file_name":"3402313.pdf","download_url":"https://www.academia.edu/attachments/91942710/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Association_Testing_of_Previously_Report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91942710/3402313-libre.pdf?1664852908=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_Testing_of_Previously_Report.pdf\u0026Expires=1733974178\u0026Signature=aYcQBFxuTKvYESUNWU--xo39MFhTIZqd-mZr7aSNnxxiRMPH3wkAEBniwtooX3g-azxXlk3ODYqKZXMz5mrWrvOvvyr3cysXLTLdaG3MhlulDhctsWKfTva69awAoyx8wt-USPAs0lC-ds35ze5z7pxloSKk3Y9SYoo9T3yuUmpA61OBiUqPboSrCxx0kSgRy2jUDH4KipVX-ga3zz08cgb~EoVoyKKA6DHQ~iLKjBdT73j4b-m-HhgCctX2KqJ3URzElMaDgyqG4t0g9w1mMxEF4-UnYA0s5YR1ox6a9Cwj3PLK1INS4e5ea0QGa6dHZH-j5uXrhTsJxV4PvQhZJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4581,"name":"Diabetes","url":"https://www.academia.edu/Documents/in/Diabetes"},{"id":29842,"name":"Ireland","url":"https://www.academia.edu/Documents/in/Ireland"},{"id":46676,"name":"Finland","url":"https://www.academia.edu/Documents/in/Finland"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":4053741,"name":"Diabetic nephropathies","url":"https://www.academia.edu/Documents/in/Diabetic_nephropathies"}],"urls":[{"id":24440642,"url":"https://journals.org/diabetes/diabetes/article-pdf/61/8/2187/561137/2187.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396091"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396091/Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic"><img alt="Research paper thumbnail of Concurrent Session 26: Approaches to Tolerance in the Clinic" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396091/Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic">Concurrent Session 26: Approaches to Tolerance in the Clinic</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396091"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396091"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396091; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396091]").text(description); $(".js-view-count[data-work-id=85396091]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396091; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396091']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396091, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396091]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396091,"title":"Concurrent Session 26: Approaches to Tolerance in the Clinic","translated_title":"","metadata":{"abstract":"312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...","publication_date":{"day":null,"month":null,"year":2006,"errors":{}}},"translated_abstract":"312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...","internal_url":"https://www.academia.edu/85396091/Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic","translated_internal_url":"","created_at":"2022-08-22T16:16:28.028-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Concurrent_Session_26_Approaches_to_Tolerance_in_the_Clinic","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"312 PRESERVED HUMORAL AND CELULAR RESPONSE TO INFLUENZA VACCINATION IN HUMAN RECIPIENTS NATURALLY TOLERANT TO A KIDNEY ALLOGRAFT. Caroline Ballet, Gwénaëlle Roussey-Kesler, Jean-Thierry Aubin, Sophie Brouard, Magali Giral, Patrick Miqueu, Stéphanie Louis, Sylvie van der Werf, Jean-Paul Soulillou. U643, INSERM, Nantes, France; URA196, CNRS, Paris, France. We have recently gathered a small cohort of rare kidney recipients who enjoy unaltered graft function years after interruption of their immunosuppressive treatment and are considered as “operationally tolerant”. These patients do not present an increase in the frequency of severe infection episodes suggesting no major immunoincompetence. To better assess the extent to which this state of “operational tolerance” is specific to the graft and is not the result of a global immunodeficiency, we prospectivelly analyzed the immune response of such patients following influenza vaccination. Immune responses of “operationally tolerant” patien...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396090"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396090/Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors"><img alt="Research paper thumbnail of Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396090/Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors">Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396090"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396090"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396090; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396090]").text(description); $(".js-view-count[data-work-id=85396090]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396090; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396090']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396090, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396090]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396090,"title":"Race, Education, and Gender Disparities in Transplantation of Kidneys From Hepatitis C Viremic Donors","translated_title":"","metadata":{"abstract":"Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.","internal_url":"https://www.academia.edu/85396090/Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors","translated_internal_url":"","created_at":"2022-08-22T16:16:27.818-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Race_Education_and_Gender_Disparities_in_Transplantation_of_Kidneys_From_Hepatitis_C_Viremic_Donors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Background. Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number of life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption of this practice has been shared equitably, especially among disadvantaged groups. Methods. We evaluated United Network for Organ Sharing data on HCV-seronegative adult deceased-donor kidney transplant recipients from January 1, 2017, to June 12, 2020. We compared recipients of a kidney from an HCV antibody− (Ab−)/nucleic acid test− (NAT−), HCV Ab+/NAT−, and HCV NAT+ donor. The primary covariates were as follows: (1) race/ethnicity; (2) female sex; and (3) highest level of education. Models included variables associated with being offered an HCV NAT+ kidney. We fit mixed-effects multinomial logistic regression models with the center as a random effect to account for patient clustering. Results. Of 48 255 adult kidney-alone deceased-donor kidney transplant HCV-seronegative recipients, 1641 (3.4%) donors were HCV NAT+−, increasing from 0.3% (January 2017–June 2017) to 6.9% (January 2020–June 2020). In multivariable models, racial/ethnic minorities, women, and those with less education were significantly less likely to receive a kidney from an HCV NAT+ donor relative to an HCV Ab−/NAT− and HCV Ab+/NAT− donor. The disparities were most pronounced among Hispanic and Asian patients with less educational attainment (grade school, high school, or some college/tech school). Conclusions. Despite an increase in transplants from HCV NAT+ donors, we found substantial racial/ethnic disparities in transplantation of these kidneys. These data highlight how the benefits of a scientific breakthrough are often made less available to disadvantaged patients.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247825,"url":"https://journals.lww.com/10.1097/TP.0000000000003511"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396089"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396089/Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond"><img alt="Research paper thumbnail of Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond" class="work-thumbnail" src="https://attachments.academia-assets.com/90106790/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396089/Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond">Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond</a></div><div class="wp-workCard_item"><span>Frontiers in Medicine</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a03b0d611a61dc7eb51b33f97ee1cb2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106790,"asset_id":85396089,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106790/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396089"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396089"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396089; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396089]").text(description); $(".js-view-count[data-work-id=85396089]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396089; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396089']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396089, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3a03b0d611a61dc7eb51b33f97ee1cb2" } } $('.js-work-strip[data-work-id=85396089]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396089,"title":"Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond","translated_title":"","metadata":{"publisher":"Frontiers Media SA","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Frontiers in Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396089/Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond","translated_internal_url":"","created_at":"2022-08-22T16:16:27.617-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106790,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106790/thumbnails/1.jpg","file_name":"fmed-07-568201.pdf","download_url":"https://www.academia.edu/attachments/90106790/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bridging_Office_Based_Care_With_the_Virt.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106790/fmed-07-568201-libre.pdf?1661211042=\u0026response-content-disposition=attachment%3B+filename%3DBridging_Office_Based_Care_With_the_Virt.pdf\u0026Expires=1733974178\u0026Signature=edz6dXS1Ku1FaLiiKo3KVhkTsoIMkkcxNprli2JKeE0sRGoJPrcF~N~U93AwwfU~d1DTJD97GLSwQ9cCG1mTO~OTDSh3QEcUyymfjC~Uwh3kDtdwrOOhgiR1v8uDLV8ocLrhzYWmsXIGZiuZK~72IBCu2ZkS6oSFw5bzrXuKtuco7oEqzLTQFNtW82oSiYfPtfEejcxXpWm2QysqzCgkm9aES0qjnuWGw2mzZyb5rAE4scLbjpqTjCLaPHdZLBPaiew0yyJPKGN3dUqrrCb3TN6a2GWylszM9oxB-R68i6Dg4cXEVM3F5NmuC2iQ6meoY1U-jXiA5WDcIgVr7dSocg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bridging_Office_Based_Care_With_the_Virtual_Practice_Care_Model_Evolving_Care_for_Chronic_Kidney_Disease_Patients_in_the_COVID_19_Pandemic_And_Beyond","translated_slug":"","page_count":10,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106790,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106790/thumbnails/1.jpg","file_name":"fmed-07-568201.pdf","download_url":"https://www.academia.edu/attachments/90106790/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bridging_Office_Based_Care_With_the_Virt.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106790/fmed-07-568201-libre.pdf?1661211042=\u0026response-content-disposition=attachment%3B+filename%3DBridging_Office_Based_Care_With_the_Virt.pdf\u0026Expires=1733974178\u0026Signature=edz6dXS1Ku1FaLiiKo3KVhkTsoIMkkcxNprli2JKeE0sRGoJPrcF~N~U93AwwfU~d1DTJD97GLSwQ9cCG1mTO~OTDSh3QEcUyymfjC~Uwh3kDtdwrOOhgiR1v8uDLV8ocLrhzYWmsXIGZiuZK~72IBCu2ZkS6oSFw5bzrXuKtuco7oEqzLTQFNtW82oSiYfPtfEejcxXpWm2QysqzCgkm9aES0qjnuWGw2mzZyb5rAE4scLbjpqTjCLaPHdZLBPaiew0yyJPKGN3dUqrrCb3TN6a2GWylszM9oxB-R68i6Dg4cXEVM3F5NmuC2iQ6meoY1U-jXiA5WDcIgVr7dSocg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":1028827,"name":"Pandemic","url":"https://www.academia.edu/Documents/in/Pandemic"}],"urls":[{"id":23247824,"url":"https://www.frontiersin.org/articles/10.3389/fmed.2020.568201/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396088"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396088/Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning"><img alt="Research paper thumbnail of Immediate Administration of Antiviral Therapy after Transplantation of Hepatitis C‐infected Livers into Uninfected Recipients: Implications for Therapeutic Planning" class="work-thumbnail" src="https://attachments.academia-assets.com/90106786/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396088/Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning">Immediate Administration of Antiviral Therapy after Transplantation of Hepatitis C‐infected Livers into Uninfected Recipients: Implications for Therapeutic Planning</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients ha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor derived HCV-infection, and should be administered early in the post-transplant period. However, evidence on the safety and efficacy of an immediate DAA treatment approach, including how to manage logistical barriers surrounding timely DAA procurement, are required prior to broader use of HCV-positive donor organs. We report the results of a trial in which fourteen HCV-negative patients underwent successful liver transplantation from HCV-positive donors. Nine patients received viremic (nucleic acid testing (NAT)-positive) livers, and started a 12-week course of oral glecaprevirpibrentasvir (GP) within 5 days of transplant. Five patients received livers from HCV antibodypositive non-viremic donors and were followed using a reactive approach. Survival in NAT-positive recipients is 100% at a median follow-up of 46 weeks. An immediate treatment approach for HCV NAT-positive liver transplantation into uninfected recipients is safe and efficacious. Securing payer approval for DAAs early in the post-transplant course could enable need-based allocation of HCV-positive donor organs irrespective of candidate HCV status, while averting chronic HCV allograft infection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2d6d862ffeef5b9d9b4b3c46c4e29f6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106786,"asset_id":85396088,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106786/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396088"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396088"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396088; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396088]").text(description); $(".js-view-count[data-work-id=85396088]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396088; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396088']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396088, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2d6d862ffeef5b9d9b4b3c46c4e29f6b" } } $('.js-work-strip[data-work-id=85396088]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396088,"title":"Immediate Administration of Antiviral Therapy after Transplantation of Hepatitis C‐infected Livers into Uninfected Recipients: Implications for Therapeutic Planning","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor derived HCV-infection, and should be administered early in the post-transplant period. However, evidence on the safety and efficacy of an immediate DAA treatment approach, including how to manage logistical barriers surrounding timely DAA procurement, are required prior to broader use of HCV-positive donor organs. We report the results of a trial in which fourteen HCV-negative patients underwent successful liver transplantation from HCV-positive donors. Nine patients received viremic (nucleic acid testing (NAT)-positive) livers, and started a 12-week course of oral glecaprevirpibrentasvir (GP) within 5 days of transplant. Five patients received livers from HCV antibodypositive non-viremic donors and were followed using a reactive approach. Survival in NAT-positive recipients is 100% at a median follow-up of 46 weeks. An immediate treatment approach for HCV NAT-positive liver transplantation into uninfected recipients is safe and efficacious. Securing payer approval for DAAs early in the post-transplant course could enable need-based allocation of HCV-positive donor organs irrespective of candidate HCV status, while averting chronic HCV allograft infection.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"American Journal of Transplantation","grobid_abstract_attachment_id":90106786},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396088/Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning","translated_internal_url":"","created_at":"2022-08-22T16:16:27.414-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106786,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106786/thumbnails/1.jpg","file_name":"ajt.1576820220822-1-1lelib3.pdf","download_url":"https://www.academia.edu/attachments/90106786/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immediate_Administration_of_Antiviral_Th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106786/ajt.1576820220822-1-1lelib3-libre.pdf?1661211041=\u0026response-content-disposition=attachment%3B+filename%3DImmediate_Administration_of_Antiviral_Th.pdf\u0026Expires=1733974178\u0026Signature=HdxYJOfZp2~xcTryihhoHwArx7hu8sdfIwRFeXT91r3~jGvAJ3YL4BytOZvIhOzDcYUa3VSM7RTXef-S~xw7KveITe3H~u9-huGNDuZ35HX7-KSKEF5-iVETq~GpqU~67OE~Tpc23TIZ-M0YNHmwAJwNYIRvxXqsHre2EEqahW66FOZcLSqmiBWiL73Es1Lt8GjNTuD~r31ALp4lc~uR-kEIfaNkQVzMs2~rUJQEAHIWVuAcd5tQRrIPk6Lh-C7N1WzddgvcDBe4MBAbc7NsYupzvCQw9XV-3WZ35JkgNwoXBp4ydtTXK-XP9KiI3yonnrIhEJYJzq3189e1o-d32w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Immediate_Administration_of_Antiviral_Therapy_after_Transplantation_of_Hepatitis_C_infected_Livers_into_Uninfected_Recipients_Implications_for_Therapeutic_Planning","translated_slug":"","page_count":27,"language":"en","content_type":"Work","summary":"The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor derived HCV-infection, and should be administered early in the post-transplant period. However, evidence on the safety and efficacy of an immediate DAA treatment approach, including how to manage logistical barriers surrounding timely DAA procurement, are required prior to broader use of HCV-positive donor organs. We report the results of a trial in which fourteen HCV-negative patients underwent successful liver transplantation from HCV-positive donors. Nine patients received viremic (nucleic acid testing (NAT)-positive) livers, and started a 12-week course of oral glecaprevirpibrentasvir (GP) within 5 days of transplant. Five patients received livers from HCV antibodypositive non-viremic donors and were followed using a reactive approach. Survival in NAT-positive recipients is 100% at a median follow-up of 46 weeks. An immediate treatment approach for HCV NAT-positive liver transplantation into uninfected recipients is safe and efficacious. Securing payer approval for DAAs early in the post-transplant course could enable need-based allocation of HCV-positive donor organs irrespective of candidate HCV status, while averting chronic HCV allograft infection.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106786,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106786/thumbnails/1.jpg","file_name":"ajt.1576820220822-1-1lelib3.pdf","download_url":"https://www.academia.edu/attachments/90106786/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immediate_Administration_of_Antiviral_Th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106786/ajt.1576820220822-1-1lelib3-libre.pdf?1661211041=\u0026response-content-disposition=attachment%3B+filename%3DImmediate_Administration_of_Antiviral_Th.pdf\u0026Expires=1733974178\u0026Signature=HdxYJOfZp2~xcTryihhoHwArx7hu8sdfIwRFeXT91r3~jGvAJ3YL4BytOZvIhOzDcYUa3VSM7RTXef-S~xw7KveITe3H~u9-huGNDuZ35HX7-KSKEF5-iVETq~GpqU~67OE~Tpc23TIZ-M0YNHmwAJwNYIRvxXqsHre2EEqahW66FOZcLSqmiBWiL73Es1Lt8GjNTuD~r31ALp4lc~uR-kEIfaNkQVzMs2~rUJQEAHIWVuAcd5tQRrIPk6Lh-C7N1WzddgvcDBe4MBAbc7NsYupzvCQw9XV-3WZ35JkgNwoXBp4ydtTXK-XP9KiI3yonnrIhEJYJzq3189e1o-d32w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247823,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fajt.15768"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396087"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396087/Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure"><img alt="Research paper thumbnail of Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure" class="work-thumbnail" src="https://attachments.academia-assets.com/90106767/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396087/Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure">Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure</a></div><div class="wp-workCard_item"><span>Blood</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney tran...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="08dbc18f43f5b7e4d5f640d91ca27f56" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106767,"asset_id":85396087,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106767/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396087"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396087"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396087; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396087]").text(description); $(".js-view-count[data-work-id=85396087]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396087; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396087']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396087, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "08dbc18f43f5b7e4d5f640d91ca27f56" } } $('.js-work-strip[data-work-id=85396087]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396087,"title":"Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure","translated_title":"","metadata":{"abstract":"At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...","publisher":"American Society of Hematology","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Blood"},"translated_abstract":"At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...","internal_url":"https://www.academia.edu/85396087/Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure","translated_internal_url":"","created_at":"2022-08-22T16:16:27.201-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106767,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106767/thumbnails/1.jpg","file_name":"bloodbld2019000775.pdf","download_url":"https://www.academia.edu/attachments/90106767/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Haploidentical_hematopoietic_cell_and_ki.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106767/bloodbld2019000775-libre.pdf?1661211043=\u0026response-content-disposition=attachment%3B+filename%3DHaploidentical_hematopoietic_cell_and_ki.pdf\u0026Expires=1733974178\u0026Signature=ISqkZRvTMJxFm4wirh-o1zQ9tdnSN0kKo5YWwwM1AZ0oOTYfk7nOZLgUrUYamvFTtARrTztECFCZVTd4bEvVVp14szzXsBL0JoKBqbKFdKEH57StVUOuE9f0~952X4dB6cL9jWTkvUCxBwE46SBasK-Th58-8QH0IUPScDtRuplWoe7dRE2qAtUptSi7g-Pqv8lQn2xHvLM83R-PofCGp29rtyTT5z-am4Ovqgiblhj~7~3-S-UXtDaB0cYE4L4D1la85L5LT~-n-mtdmm6p5eiE08kXEK1FNCzqyycpr-zm5US91U20pW6QHaQTw-ASDmovC9EH9fAB0nrHDe-FbA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Haploidentical_hematopoietic_cell_and_kidney_transplantation_for_hematological_malignancies_and_end_stage_renal_failure","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of complications of fludarabine neurological toxicity. No neurological toxicity was observed in subsequent patients who received lower fludarabine doses and more intense postfludarabine dialysis. There were no cases of grade 2 to 4 acute GVHD and 1 case of moderate chronic GVHD by 12 months. One patient experienced relapse of multiple myeloma at 30 months after HCT and d...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106767,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106767/thumbnails/1.jpg","file_name":"bloodbld2019000775.pdf","download_url":"https://www.academia.edu/attachments/90106767/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Haploidentical_hematopoietic_cell_and_ki.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106767/bloodbld2019000775-libre.pdf?1661211043=\u0026response-content-disposition=attachment%3B+filename%3DHaploidentical_hematopoietic_cell_and_ki.pdf\u0026Expires=1733974178\u0026Signature=ISqkZRvTMJxFm4wirh-o1zQ9tdnSN0kKo5YWwwM1AZ0oOTYfk7nOZLgUrUYamvFTtARrTztECFCZVTd4bEvVVp14szzXsBL0JoKBqbKFdKEH57StVUOuE9f0~952X4dB6cL9jWTkvUCxBwE46SBasK-Th58-8QH0IUPScDtRuplWoe7dRE2qAtUptSi7g-Pqv8lQn2xHvLM83R-PofCGp29rtyTT5z-am4Ovqgiblhj~7~3-S-UXtDaB0cYE4L4D1la85L5LT~-n-mtdmm6p5eiE08kXEK1FNCzqyycpr-zm5US91U20pW6QHaQTw-ASDmovC9EH9fAB0nrHDe-FbA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":90106766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106766/thumbnails/1.jpg","file_name":"bloodbld2019000775.pdf","download_url":"https://www.academia.edu/attachments/90106766/download_file","bulk_download_file_name":"Haploidentical_hematopoietic_cell_and_ki.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106766/bloodbld2019000775-libre.pdf?1661211045=\u0026response-content-disposition=attachment%3B+filename%3DHaploidentical_hematopoietic_cell_and_ki.pdf\u0026Expires=1733974178\u0026Signature=BNdvrbDZO03HWAnS2FgkA6MhoxtkeGbEFZZaiECR~2PV5zO105R59ZfDINMnULli2LgL-sDK5frqV47ROzKefvSFNPNS8ax75Kp2nspMC7KEq7eqB45W4Sf4Fe7DreGKi8OfBX5MzbPV5yzGruMV8hKJVvefpuZiWQfsAP52RrEgakSaR6sxFQhOhUGK1fdOcw98dG7cbkXSymz0JBN20BJ40Z9pw-77DLKdwN3apd9XvZLebjoXo0CxPPeby3afnhteI5N7FoRJP-AvonZvWN1cT0hRXjxO1oyHc0YPS9ZF9DiYboP7KTuWeq7Vo5loPPlHEYRsAYmkllBfMpClhg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":23247822,"url":"http://ashpublications.org/blood/article-pdf/134/2/211/1553913/bloodbld2019000775.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396086"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396086/BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience"><img alt="Research paper thumbnail of BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396086/BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience">BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience</a></div><div class="wp-workCard_item"><span>Clinical transplants</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396086"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396086"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396086; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396086]").text(description); $(".js-view-count[data-work-id=85396086]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396086; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396086']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396086, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396086]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396086,"title":"BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience","translated_title":"","metadata":{"abstract":"BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Clinical transplants"},"translated_abstract":"BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...","internal_url":"https://www.academia.edu/85396086/BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience","translated_internal_url":"","created_at":"2022-08-22T16:16:27.078-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"BK_Virus_After_Kidney_Transplantation_A_Review_of_Screening_and_Treatment_Strategies_and_a_Summary_of_the_Massachusetts_General_Hospital_Experience","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"BK virus (BKV) is a common infection encountered after kidney transplantation. BKV is associated with a spectrum of manifestations, starting with sub-clinical viruria, followed by viremia and BKV-associated nephropathy. Standard of care includes routine post-transplant screening for BK viruria and/or viremia. Both the Kidney Disease Improving Global Outcomes and the American Society of Transplantation Infectious Diseases Community of Practice have published screening recommendations. Although they vary slightly, they both highlight the importance of early detection with serial screening. Once BK viremia is detected, the standard management approach includes a reduction of immunosuppression. Guidelines differ slightly about the sequence of the immunosuppression reduction, but the end result is the same: lowering the overall immunosuppressive burden in the patient with BKV infection. At the Massachusetts General Hospital, from 2007 to 2009, there was no BKV screening protocol in place...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":112992,"name":"BK virus","url":"https://www.academia.edu/Documents/in/BK_virus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396085"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/85396085/Modified_organ_support_devices"><img alt="Research paper thumbnail of Modified organ support devices" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/85396085/Modified_organ_support_devices">Modified organ support devices</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396085; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396085]").text(description); $(".js-view-count[data-work-id=85396085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396085, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396085,"title":"Modified organ support devices","translated_title":"","metadata":{"publication_date":{"day":4,"month":3,"year":2008,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396085/Modified_organ_support_devices","translated_internal_url":"","created_at":"2022-08-22T16:16:26.897-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Modified_organ_support_devices","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[],"urls":[{"id":23247821,"url":"http://www.freepatentsonline.com/7338461.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396084/Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension"><img alt="Research paper thumbnail of Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396084/Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension">Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension</a></div><div class="wp-workCard_item"><span>New England Journal of Medicine</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396084; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396084]").text(description); $(".js-view-count[data-work-id=85396084]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396084; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396084']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396084, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396084]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396084,"title":"Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"New England Journal of Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396084/Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension","translated_internal_url":"","created_at":"2022-08-22T16:16:26.776-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Case_records_of_the_Massachusetts_General_Hospital_Case_38_2005_A_29_year_old_pregnant_woman_with_the_nephrotic_syndrome_and_hypertension","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":1161066,"name":"New England Journalof Medicine","url":"https://www.academia.edu/Documents/in/New_England_Journalof_Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396083"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396083/Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients"><img alt="Research paper thumbnail of Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396083/Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients">Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients</a></div><div class="wp-workCard_item"><span>Progress in Transplantation</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To obtain information on menstrual patterns before and after transplantation, desire for future p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396083"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396083"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396083; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396083]").text(description); $(".js-view-count[data-work-id=85396083]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396083; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396083']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396083, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396083]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396083,"title":"Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients","translated_title":"","metadata":{"abstract":"To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.","publisher":"SAGE Publications","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Progress in Transplantation"},"translated_abstract":"To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.","internal_url":"https://www.academia.edu/85396083/Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients","translated_internal_url":"","created_at":"2022-08-22T16:16:26.637-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Reproductive_and_contraceptive_characteristics_of_premenopausal_kidney_transplant_recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"To obtain information on menstrual patterns before and after transplantation, desire for future pregnancy, and use of contraception among premenopausal kidney transplant recipients. This observational study collected information using self-administered anonymous questionnaires during a routine outpatient clinic visit. Of the 107 women who completed the questionnaire, 41 identified themselves as being premenopausal. Among the 41 premenopausal women, approximately half of the women reported their current menstrual patterns as normal and 26% were not using any form of contraception. Overall, 10 women (24%) reported a desire to become pregnant and 4 women (10%) had a successful pregnancy after transplantation. Most of the women who desired a future pregnancy (8/10) were receiving an immunosuppressive regimen that included mycophenolate mofetil. Kidney transplantation in the current era is associated with a return of normal menstrual function in the majority of female transplant recipients. A substantial fraction of women desire pregnancy after transplantation and many are using an immunosuppressive drug with limited safety data on use during pregnancy. More caution should be used with the use of newer immunosuppressive agents in sexually active premenopausal transplant recipients until more safety data are available.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":16038,"name":"Menstruation","url":"https://www.academia.edu/Documents/in/Menstruation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49161,"name":"Safety","url":"https://www.academia.edu/Documents/in/Safety"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires"},{"id":478597,"name":"Reproductive behavior","url":"https://www.academia.edu/Documents/in/Reproductive_behavior"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":2592713,"name":"Premenopause","url":"https://www.academia.edu/Documents/in/Premenopause"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396081"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396081/Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization"><img alt="Research paper thumbnail of Neutrophil chemotactic factors derived from conjunctival epithelial cells: preliminary biochemical characterization" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396081/Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization">Neutrophil chemotactic factors derived from conjunctival epithelial cells: preliminary biochemical characterization</a></div><div class="wp-workCard_item"><span>The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396081"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396081"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396081; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396081]").text(description); $(".js-view-count[data-work-id=85396081]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396081; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396081']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396081, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396081]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396081,"title":"Neutrophil chemotactic factors derived from conjunctival epithelial cells: preliminary biochemical characterization","translated_title":"","metadata":{"abstract":"We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc"},"translated_abstract":"We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...","internal_url":"https://www.academia.edu/85396081/Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization","translated_internal_url":"","created_at":"2022-08-22T16:16:26.512-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Neutrophil_chemotactic_factors_derived_from_conjunctival_epithelial_cells_preliminary_biochemical_characterization","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"We have previously reported on the release of neutrophil chemotactic factors (NCF) from injured conjunctival tissue. The present study was designed to biochemically characterize these conjunctiva-derived chemotactic factors and determine their biological activities. Bulbar conjunctiva was surgically removed from a rabbit eye and incubated with 250 microL of minimal essential medium (MEM) for 6 hours at 37 degrees C in a 5% CO2 atmosphere. Chemotactic activity was assayed using modified Boyden chambers with rabbit peritoneal neutrophils as indicator cells. Following treatment with subtilisin protease for 90 minutes, chemotactic activity of the conjunctival factors was reduced by 74%. Similarly, activity was lost after heating at 56 degrees C for 60 minutes (41% inhibition). Using ultrafiltration techniques, we showed that the majority of the chemotactic activity remained above a 100 kilodalton filter, suggesting the existence of high molecular weight factors. We also showed that the ...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28404,"name":"Conjunctiva","url":"https://www.academia.edu/Documents/in/Conjunctiva"},{"id":37447,"name":"Ultrafiltration","url":"https://www.academia.edu/Documents/in/Ultrafiltration"},{"id":170276,"name":"Chemotaxis","url":"https://www.academia.edu/Documents/in/Chemotaxis"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins"},{"id":201241,"name":"Affinity chromatography","url":"https://www.academia.edu/Documents/in/Affinity_chromatography"},{"id":203965,"name":"Ion Exchange Chromatography","url":"https://www.academia.edu/Documents/in/Ion_Exchange_Chromatography"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":295260,"name":"Neutrophils","url":"https://www.academia.edu/Documents/in/Neutrophils"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"},{"id":376494,"name":"Epithelium","url":"https://www.academia.edu/Documents/in/Epithelium"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396080"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396080/Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients"><img alt="Research paper thumbnail of Significance of Anticardiolipin Antibodies (Aca) in Renal Allograft Recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396080/Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients">Significance of Anticardiolipin Antibodies (Aca) in Renal Allograft Recipients</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396080"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396080"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396080; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396080]").text(description); $(".js-view-count[data-work-id=85396080]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396080; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396080']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396080, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396080]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396080,"title":"Significance of Anticardiolipin Antibodies (Aca) in Renal Allograft Recipients","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396080/Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients","translated_internal_url":"","created_at":"2022-08-22T16:16:26.304-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Significance_of_Anticardiolipin_Antibodies_Aca_in_Renal_Allograft_Recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247819,"url":"http://journals.lww.com/00007890-199905150-00331"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396079"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396079/Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection"><img alt="Research paper thumbnail of Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection" class="work-thumbnail" src="https://attachments.academia-assets.com/90106787/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396079/Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection">Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efdc032abe910e3437a0dfafb4dea9c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106787,"asset_id":85396079,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106787/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396079"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396079"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396079; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396079]").text(description); $(".js-view-count[data-work-id=85396079]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396079; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396079']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396079, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "efdc032abe910e3437a0dfafb4dea9c1" } } $('.js-work-strip[data-work-id=85396079]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396079,"title":"Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection","translated_title":"","metadata":{"publisher":"Elsevier BV","ai_abstract":"This study investigates the incidence of tacrolimus (TAC)-associated posttransplant diabetes mellitus (PTDM) in renal transplant recipients, with a focus on the potential influence of hepatitis C virus (HCV) infection. By reviewing the charts of 114 renal allograft recipients who received TAC, the analysis aims to identify risk factors, including HCV status, that may contribute to the development of PTDM. Results indicate that the diabetogenic effects of TAC could be accentuated by HCV infection, particularly at higher TAC levels, suggesting that lower dosages might reduce PTDM incidence in HCV-positive recipients.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Transplantation Proceedings"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396079/Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection","translated_internal_url":"","created_at":"2022-08-22T16:16:26.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106787,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106787/thumbnails/1.jpg","file_name":"s0041-1345_2802_2903060-920220822-1-scufv4.pdf","download_url":"https://www.academia.edu/attachments/90106787/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tacrolimus_associated_posttransplant_dia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106787/s0041-1345_2802_2903060-920220822-1-scufv4-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTacrolimus_associated_posttransplant_dia.pdf\u0026Expires=1733974178\u0026Signature=JKmlWmL4W3L55XfJrUE-6Yn51vRvm5fYpEXJ-XgPEsqIn7zg-b~oKfemczeYr8Lno41yjqLL0w3-TSLBcieMA11dpCDG9WHKkmlW8x65IAYFfzW7984NhRGMVGUezqmKy2rwiE0jg3FhmqT2ZFBGzr8ToFRiOtvI~kypBjOe919uPQNeeEr3VEZmp5va82qunP6h33huwLsVSEJZYt7f3-VZsaVfv~tbaz6nreA4BMJD1AANLu2o8qSc~17YpdN3axB-kdUTfTmuQEKMqquKsWIliN1uWUPZmkDDgQfdfkpvoneHe6Tal~xWdtm1xC5LHOk31yvQ~jZdAuBiz9yJbQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tacrolimus_associated_posttransplant_diabetes_mellitus_in_renal_transplant_recipients_role_of_hepatitis_c_infection","translated_slug":"","page_count":3,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106787,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106787/thumbnails/1.jpg","file_name":"s0041-1345_2802_2903060-920220822-1-scufv4.pdf","download_url":"https://www.academia.edu/attachments/90106787/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tacrolimus_associated_posttransplant_dia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106787/s0041-1345_2802_2903060-920220822-1-scufv4-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTacrolimus_associated_posttransplant_dia.pdf\u0026Expires=1733974178\u0026Signature=JKmlWmL4W3L55XfJrUE-6Yn51vRvm5fYpEXJ-XgPEsqIn7zg-b~oKfemczeYr8Lno41yjqLL0w3-TSLBcieMA11dpCDG9WHKkmlW8x65IAYFfzW7984NhRGMVGUezqmKy2rwiE0jg3FhmqT2ZFBGzr8ToFRiOtvI~kypBjOe919uPQNeeEr3VEZmp5va82qunP6h33huwLsVSEJZYt7f3-VZsaVfv~tbaz6nreA4BMJD1AANLu2o8qSc~17YpdN3axB-kdUTfTmuQEKMqquKsWIliN1uWUPZmkDDgQfdfkpvoneHe6Tal~xWdtm1xC5LHOk31yvQ~jZdAuBiz9yJbQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":240356,"name":"Boston","url":"https://www.academia.edu/Documents/in/Boston"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396078"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396078/Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2"><img alt="Research paper thumbnail of Anticardiolipin Antibodies and Hepatic Artery Thrombosis After Liver TRANSPLANTATION1,2" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396078/Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2">Anticardiolipin Antibodies and Hepatic Artery Thrombosis After Liver TRANSPLANTATION1,2</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. V...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher&amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer &amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396078"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396078"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396078; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396078]").text(description); $(".js-view-count[data-work-id=85396078]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396078; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396078']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396078, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396078]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396078,"title":"Anticardiolipin Antibodies and Hepatic Artery Thrombosis After Liver TRANSPLANTATION1,2","translated_title":"","metadata":{"abstract":"Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher\u0026amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer \u0026amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher\u0026amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer \u0026amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.","internal_url":"https://www.academia.edu/85396078/Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2","translated_internal_url":"","created_at":"2022-08-22T16:16:25.966-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Anticardiolipin_Antibodies_and_Hepatic_Artery_Thrombosis_After_Liver_TRANSPLANTATION1_2","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher\u0026amp;#39;s exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer \u0026amp;gt;4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2892963,"name":"immunoglobulin M","url":"https://www.academia.edu/Documents/in/immunoglobulin_M"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247818,"url":"http://journals.lww.com/00007890-199711150-00021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396077/Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation"><img alt="Research paper thumbnail of Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/90106788/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396077/Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation">Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fa1a4f3797f0deff84b6fb55d30cde38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106788,"asset_id":85396077,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106788/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396077]").text(description); $(".js-view-count[data-work-id=85396077]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396077']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396077, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fa1a4f3797f0deff84b6fb55d30cde38" } } $('.js-work-strip[data-work-id=85396077]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396077,"title":"Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","ai_abstract":"The paper discusses the case of a 45-year-old male liver transplant recipient with hepatitis C virus (HCV)-associated complications, specifically nephrotic syndrome due to mixed cryoglobulinemic glomerulonephritis. Following the onset of renal dysfunction, a combination therapy of interferon alfa-2b and ribavirin was administered, leading to a significant reduction in HCV RNA levels and normalization of renal function. The findings emphasize the potential efficacy of antiviral therapy post-liver transplantation in managing renal manifestations associated with HCV infection.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396077/Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation","translated_internal_url":"","created_at":"2022-08-22T16:16:25.752-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106788,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106788/thumbnails/1.jpg","file_name":"00007890-200212270-0002120220822-1-17xc10n.pdf","download_url":"https://www.academia.edu/attachments/90106788/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Remission_of_hepatitis_C_virus_associate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106788/00007890-200212270-0002120220822-1-17xc10n-libre.pdf?1661211039=\u0026response-content-disposition=attachment%3B+filename%3DRemission_of_hepatitis_C_virus_associate.pdf\u0026Expires=1733974178\u0026Signature=LMR~VD6VXz9SSDNswCZr2ICN6cIo0H6euK7ULENgf2DhzRBFfjgKEmasjhyjsmOIcnR7NHGpddJk913kq8mUCv8cvmL6RuSjsqTnWyiL3PUZYkisj-Kcpo3LbG~SZMTII6WLTcGGEf9qR4wAn-5DfTz3pAgcFaOlFilB0cqGxEqAUKcMtxNhqtfsH7g9LNSabdOHDXVsaEDtuRTdrZsWF70lAt71zheVUvTzXJRV5i3jya28M8sRL4P47Tym-pJaSoa0m17pUj-xAUL1SSX5AH6vjsRmB7s5V8Dzuolok61DKTjqh~9gztsXqswyz-cPhKFshMu~YgWqq3ZQbFcrVw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Remission_of_hepatitis_C_virus_associated_cryoglobulinemic_glomerulonephritis_with_interferon_alfa_2b_and_ribavirin_combination_therapy_after_liver_transplantation","translated_slug":"","page_count":2,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106788,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106788/thumbnails/1.jpg","file_name":"00007890-200212270-0002120220822-1-17xc10n.pdf","download_url":"https://www.academia.edu/attachments/90106788/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Remission_of_hepatitis_C_virus_associate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106788/00007890-200212270-0002120220822-1-17xc10n-libre.pdf?1661211039=\u0026response-content-disposition=attachment%3B+filename%3DRemission_of_hepatitis_C_virus_associate.pdf\u0026Expires=1733974178\u0026Signature=LMR~VD6VXz9SSDNswCZr2ICN6cIo0H6euK7ULENgf2DhzRBFfjgKEmasjhyjsmOIcnR7NHGpddJk913kq8mUCv8cvmL6RuSjsqTnWyiL3PUZYkisj-Kcpo3LbG~SZMTII6WLTcGGEf9qR4wAn-5DfTz3pAgcFaOlFilB0cqGxEqAUKcMtxNhqtfsH7g9LNSabdOHDXVsaEDtuRTdrZsWF70lAt71zheVUvTzXJRV5i3jya28M8sRL4P47Tym-pJaSoa0m17pUj-xAUL1SSX5AH6vjsRmB7s5V8Dzuolok61DKTjqh~9gztsXqswyz-cPhKFshMu~YgWqq3ZQbFcrVw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins"},{"id":1457700,"name":"Ribavirin","url":"https://www.academia.edu/Documents/in/Ribavirin"},{"id":1601249,"name":"Glomerulonephritis","url":"https://www.academia.edu/Documents/in/Glomerulonephritis"},{"id":1622318,"name":"Antiviral Agents","url":"https://www.academia.edu/Documents/in/Antiviral_Agents"},{"id":2028055,"name":"Interferon Alpha","url":"https://www.academia.edu/Documents/in/Interferon_Alpha"},{"id":2425458,"name":"Cryoglobulinemia","url":"https://www.academia.edu/Documents/in/Cryoglobulinemia"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247817,"url":"http://journals.lww.com/00007890-200212270-00021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396076"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396076/Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1"><img alt="Research paper thumbnail of Renal Disease Associated with Hepatitis C Infection After Kidney and Liver TRANSPLANTATION1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396076/Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1">Renal Disease Associated with Hepatitis C Infection After Kidney and Liver TRANSPLANTATION1</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Win...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396076"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396076"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396076; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396076]").text(description); $(".js-view-count[data-work-id=85396076]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396076; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396076']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396076, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396076]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396076,"title":"Renal Disease Associated with Hepatitis C Infection After Kidney and Liver TRANSPLANTATION1","translated_title":"","metadata":{"abstract":"... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...","internal_url":"https://www.academia.edu/85396076/Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1","translated_internal_url":"","created_at":"2022-08-22T16:16:25.564-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Renal_Disease_Associated_with_Hepatitis_C_Infection_After_Kidney_and_Liver_TRANSPLANTATION1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"... Baid, Seema2; Cosimi, A. Benedict3; Tolkoff-Rubin, Nina2 3; Colvin, Robert B.4; Williams, Winfred W.2 3; Pascual, Manuel2 3 5. Article Outline. Collapse Box ... Recurrent MPGN in association with HCV infection has also been described in another case report ( 30 ). ...","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":1180098,"name":"Renal disease","url":"https://www.academia.edu/Documents/in/Renal_disease"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247816,"url":"http://journals.lww.com/00007890-200007270-00001"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396075"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396075/Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1"><img alt="Research paper thumbnail of Nephrotic Syndrome After Liver Transplantation in a Patient with Hepatitis C Virus-Associated GLOMERULONEPHRITIS1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396075/Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1">Nephrotic Syndrome After Liver Transplantation in a Patient with Hepatitis C Virus-Associated GLOMERULONEPHRITIS1</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In recent years, hepatitis C virus infection has been reported to be typically associated with me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396075"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396075]").text(description); $(".js-view-count[data-work-id=85396075]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396075']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396075, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396075]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396075,"title":"Nephrotic Syndrome After Liver Transplantation in a Patient with Hepatitis C Virus-Associated GLOMERULONEPHRITIS1","translated_title":"","metadata":{"abstract":"In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.","internal_url":"https://www.academia.edu/85396075/Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1","translated_internal_url":"","created_at":"2022-08-22T16:16:25.432-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Nephrotic_Syndrome_After_Liver_Transplantation_in_a_Patient_with_Hepatitis_C_Virus_Associated_GLOMERULONEPHRITIS1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C"},{"id":63890,"name":"Complication","url":"https://www.academia.edu/Documents/in/Complication"},{"id":71284,"name":"Enalapril","url":"https://www.academia.edu/Documents/in/Enalapril"},{"id":140320,"name":"Hepatitis C Virus","url":"https://www.academia.edu/Documents/in/Hepatitis_C_Virus"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":777616,"name":"Proteinuria","url":"https://www.academia.edu/Documents/in/Proteinuria"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":1601249,"name":"Glomerulonephritis","url":"https://www.academia.edu/Documents/in/Glomerulonephritis"},{"id":1773304,"name":"Nephrotic syndrome","url":"https://www.academia.edu/Documents/in/Nephrotic_syndrome"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation"},{"id":2717373,"name":"Hepacivirus","url":"https://www.academia.edu/Documents/in/Hepacivirus"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396074"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396074/Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation"><img alt="Research paper thumbnail of Treatment of Refractory Acute Humoral Rejection in Kidney Transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/90106785/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396074/Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation">Treatment of Refractory Acute Humoral Rejection in Kidney Transplantation</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="066ccf15c8b1ab51993d21b135886e3a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90106785,"asset_id":85396074,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90106785/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396074"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396074"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396074; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396074]").text(description); $(".js-view-count[data-work-id=85396074]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396074; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396074']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396074, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "066ccf15c8b1ab51993d21b135886e3a" } } $('.js-work-strip[data-work-id=85396074]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396074,"title":"Treatment of Refractory Acute Humoral Rejection in Kidney Transplantation","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85396074/Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation","translated_internal_url":"","created_at":"2022-08-22T16:16:25.241-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90106785,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106785/thumbnails/1.jpg","file_name":"00007890-200004271-0067220220822-1-1wpzx5k.pdf","download_url":"https://www.academia.edu/attachments/90106785/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_Refractory_Acute_Humoral_Re.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106785/00007890-200004271-0067220220822-1-1wpzx5k-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_Refractory_Acute_Humoral_Re.pdf\u0026Expires=1733974178\u0026Signature=D1Kpj0t7zuM6hzF-4n~8JArVXci0RhwNtKxcQ4CNYzYBPzccDnBWYoVnUbPft6Vmfi96Rv3g1nq1qzlPcro10MJ53W~zsyzWT~HHnKNjCASXzDrWqh1srgW4NXU1HInnpIxgJL1dwlDDGE-SsXfvLJvQjukGlN0TFXNaCzzm9O4j3meSzUinoW0o91Or2SJgfTuZljWMfyJsm81hrI2bdi2NfMeH~CNqmHOLjhagK3KdqVASD9Q8GGqmM5ZG1v-ZVffSy5gZv3vT0uTlNpXws2sN34gZGoyjDjXLGXIQ9oiAmAfklmp3Q1p96jfbq7OJRiiqLst7wL1DjxoEfVKpWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Treatment_of_Refractory_Acute_Humoral_Rejection_in_Kidney_Transplantation","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[{"id":90106785,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90106785/thumbnails/1.jpg","file_name":"00007890-200004271-0067220220822-1-1wpzx5k.pdf","download_url":"https://www.academia.edu/attachments/90106785/download_file?st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&st=MTczMzk3MDU3OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_Refractory_Acute_Humoral_Re.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90106785/00007890-200004271-0067220220822-1-1wpzx5k-libre.pdf?1661211040=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_Refractory_Acute_Humoral_Re.pdf\u0026Expires=1733974178\u0026Signature=D1Kpj0t7zuM6hzF-4n~8JArVXci0RhwNtKxcQ4CNYzYBPzccDnBWYoVnUbPft6Vmfi96Rv3g1nq1qzlPcro10MJ53W~zsyzWT~HHnKNjCASXzDrWqh1srgW4NXU1HInnpIxgJL1dwlDDGE-SsXfvLJvQjukGlN0TFXNaCzzm9O4j3meSzUinoW0o91Or2SJgfTuZljWMfyJsm81hrI2bdi2NfMeH~CNqmHOLjhagK3KdqVASD9Q8GGqmM5ZG1v-ZVffSy5gZv3vT0uTlNpXws2sN34gZGoyjDjXLGXIQ9oiAmAfklmp3Q1p96jfbq7OJRiiqLst7wL1DjxoEfVKpWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247815,"url":"http://journals.lww.com/00007890-200004271-00672"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85396073"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85396073/Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1"><img alt="Research paper thumbnail of Plasma Exchange and Tacrolimus-Mycophenolate Rescue for Acute Humoral Rejection in Kidney TRANSPLANTATION1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85396073/Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1">Plasma Exchange and Tacrolimus-Mycophenolate Rescue for Acute Humoral Rejection in Kidney TRANSPLANTATION1</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute renal allograft rejection associated with the development of donor-specific alloantibody (a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient&amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85396073"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85396073"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85396073; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85396073]").text(description); $(".js-view-count[data-work-id=85396073]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85396073; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85396073']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85396073, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85396073]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85396073,"title":"Plasma Exchange and Tacrolimus-Mycophenolate Rescue for Acute Humoral Rejection in Kidney TRANSPLANTATION1","translated_title":"","metadata":{"abstract":"Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient\u0026amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient\u0026amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.","internal_url":"https://www.academia.edu/85396073/Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1","translated_internal_url":"","created_at":"2022-08-22T16:16:25.045-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39490987,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Plasma_Exchange_and_Tacrolimus_Mycophenolate_Rescue_for_Acute_Humoral_Rejection_in_Kidney_TRANSPLANTATION1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Acute renal allograft rejection associated with the development of donor-specific alloantibody (acute humoral rejection, AHR) typically carries a poor prognosis. The best treatment of this condition remains undefined. During a 14-month period, 73 renal transplants were performed. During the first postoperative month, five recipients (6.8%) with AHR were identified. The diagnosis was based on: (1) evidence of severe rejection, resistant to steroid and antilymphocyte therapy; (2) typical pathologic features; and (3) demonstration of donor-specific alloantibody (DSA) in recipient\u0026amp;#39;s serum at the time of rejection. Pretransplant donor-specific T- and B-cell cross-matches were negative. Plasma exchange (PE, four to seven treatments per patient) significantly decreased circulating DSA to almost pretransplant levels in four of five patients, and improvement in renal function occurred in all patients. One patient had recurrent renal dysfunction in the setting of an increase in circulating DSA. A second series of five PE treatments decreased DSA and reversed the rejection episode. Rescue therapy with tacrolimus (initial mean dose: 0.14+/-0.32 mg/kg/day) and mycophenolate mofetil (2 g/day) was used in five of five and four of five patients, respectively. With a mean follow-up of 19.6+/-5.6 months, patient and allograft survival are 100%. Renal function remains excellent with a mean current serum creatinine of 1.2+/-0.3 mg/dl. (range: 0.9-1.8 mg/dl). Our findings suggest that a therapeutic approach combining PE and tacrolimus-mycophenolate mofetil rescue has the potential to improve the outcome of AHR.","owner":{"id":39490987,"first_name":"Winfred","middle_initials":null,"last_name":"Williams","page_name":"WinfredWilliams","domain_name":"independent","created_at":"2015-11-30T12:53:39.595-08:00","display_name":"Winfred Williams","url":"https://independent.academia.edu/WinfredWilliams"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":2963614,"name":" Mycophenolic Acid","url":"https://www.academia.edu/Documents/in/Mycophenolic_Acid"},{"id":3718527,"name":"Plasma exchange","url":"https://www.academia.edu/Documents/in/Plasma_exchange"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23247814,"url":"http://journals.lww.com/00007890-199812150-00008"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "a04a29cebea1d273dec490700f99f7da8af2fc6e0e7d4aea10600425d6cc1404", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="g/Iz00TuShzWSigg+jRcrJF0w55Mq/2BsyGpPMiSzUT9E/ML8shXzTDBP/CM244bsUYl91KYDCvo9ufUk5a7iA==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/WinfredWilliams" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="yh4kBWYLJfHrv6U2h/cscCHuIPicP8uS7O1tC46kcs60/+Td0C04IA00subxGP7HAdzGkYIMOji3OiPj1aAEAg==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>