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0-.7281-.089-2.5395-.089-4.1733V1h6.233v33.6175h-6.233v-2.7704h-.018zm-11.081-8.2046c0 3.3564 2.308 6.0558 5.612 6.0558 3.303 0 5.611-2.6994 5.611-6.0558 0-3.4097-2.308-6.0025-5.611-6.0025-3.304 0-5.612 2.5928-5.612 6.0025zM191.801 2.58054h2.06V1.01776h-5.772v1.56278h2.043V6.8249h1.669V2.58054zM201 6.8249V1.01776h-2.184l-1.119 2.84141-1.101-2.84141h-2.22V6.8249h1.652V3.13106l1.101 2.66382h1.065l1.101-2.68158v3.7116H201z"/> </svg> </a> </h1><a class="search-nav-link" href="#" id="search-nav-link"></a><form action="/search" class="mobile-search" id="mobile-search" method="get"><input class="mobile-search__field" name="q" placeholder="What are you looking for?" type="text" /><button class="mobile-search__icon" type="submit"></button></form></div><div class="main-nav-container__nav2"><nav class="user-actions" id="user-actions"> <ul class="user-actions__list"> <li class="user-actions__signin"> <a class="user-actions__signin-link" href="/user/login">sign in</a> </li> <li 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href="https://www.bioworld.com/womens_health">Breaking News: Healing a health divide (that’s long overdue)</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/517055-try-bioworld-for-free-for-two-weeks">Breaking News: Try BioWorld for free for two weeks</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/517055-try-bioworld-for-free-for-two-weeks">Breaking News: Try BioWorld for free for two weeks</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/714414-duchembio-files-for-ipo-to-grow-radiopharma-business">Breaking News: Duchembio files for IPO to grow radiopharma business</a></section><section class="featured-stories__wrapper -primary-3 --secondary-4"><div class="featured-stories__primary "><section class="featured-stories "> <div class="featured-stories__items-wrapper"><ul class="featured-stories__items featured-stories__items-1"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><figure class="featured-stories__image"><a class="featured-stories__thumbnail-link" data-eventname="featured-stories" data-eventcategory="click" data-eventaction="featured-stories-image" data-eventlabel="https://www.bioworld.com/articles/714822-dystrophies-affect-not-just-muscles-can-rna-editing-help" href="https://www.bioworld.com/articles/714822-dystrophies-affect-not-just-muscles-can-rna-editing-help"><img class="featured-stories__image-thumb" alt="Illustration of muscle tissue anatomy" title="Illustration of muscle tissue anatomy" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Musculoskeletal/muscle-fiber-anatomy.jpg?height=355&t=1732637386&width=640" /></a></figure><div class="featured-stories__details featured-stories__details-1"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714822-dystrophies-affect-not-just-muscles-can-rna-editing-help">Dystrophies affect not just muscles; can RNA editing help?</a></h1><div class="featured-stories__teaser">At the Breakthroughs in Muscular Dystrophy special meeting held in Chicago Nov. 19-20, 2024, and organized by the American Society of Gene & Cell Therapy (ASGCT), multiple interventions at the RNA level were among the approaches that were presented to fight muscular dystrophies.</div></div></article> </li> </ul><ul class="featured-stories__items featured-stories__items-2"> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714823-anocca-submits-cta-for-tcr-t-umbrella-trial-in-advanced-pancreatic-cancer">Anocca submits CTA for TCR T umbrella trial in advanced pancreatic cancer</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714824-longbios-lp-003-receives-nmpa-clearance-to-enter-clinic-for-food-allergy">Longbio’s LP-003 receives NMPA clearance to enter clinic for food allergy</a></h1></article> </li> </ul></div> </section></div><div class="featured-stories__secondary"><section class="featured-stories "> <ul class="featured-stories__items"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714822-dystrophies-affect-not-just-muscles-can-rna-editing-help">Dystrophies affect not just muscles; can RNA editing help?</a></h1><div class="featured-stories__teaser">At the Breakthroughs in Muscular Dystrophy special meeting held in Chicago Nov. 19-20, 2024, and organized by the American Society of Gene & Cell Therapy (ASGCT), multiple interventions at the RNA level were among the approaches that were presented to fight muscular dystrophies.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714823-anocca-submits-cta-for-tcr-t-umbrella-trial-in-advanced-pancreatic-cancer">Anocca submits CTA for TCR T umbrella trial in advanced pancreatic cancer</a></h1><div class="featured-stories__teaser"><p><span style=" font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; widows: 2; word-spacing: 0px; display: inline !important; float: none;">Anocca AB has submitted its first clinical trial application (CTA) to the EMA for a phase I/II multi-asset umbrella trial, VIDAR-1. The application covers ANOC-001 as the initial product in the VIDAR-1 program targeting mutated KRAS in advanced pancreatic cancer. </span> </p></div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714824-longbios-lp-003-receives-nmpa-clearance-to-enter-clinic-for-food-allergy">Longbio’s LP-003 receives NMPA clearance to enter clinic for food allergy</a></h1><div class="featured-stories__teaser">Longbio Pharma (Suzhou) Co. Ltd. has obtained IND approval from China’s National Medical Products Administration (NMPA) for LP-003, the company’s next-generation anti-IgE antibody, to enter a clinical trial for the treatment of food allergy.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714825-pyx-201-demonstrates-antitumor-activity-across-sarcoma-subtypes">PYX-201 demonstrates antitumor activity across sarcoma subtypes</a></h1><div class="featured-stories__teaser">Researchers from Pyxis Oncology Inc. presented preclinical data for PYX-201, an antibody drug conjugate (ADC) that targets extra domain B of fibronectin (EDB+FN).</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714834-scenic-immunology-patents-new-qc-and-isoqc-inhibitors">Scenic Immunology patents new QC and isoQC inhibitors</a></h1><div class="featured-stories__teaser">Scenic Immunology BV has disclosed glutaminyl-peptide cyclotransferase (QPCT; QC) and/or glutaminyl-peptide cyclotransferase-like protein (QPCTL; isoQC) inhibitors reported to be useful for the treatment of cancer.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714826-novel-t-cell-engager-azd-9793-has-improved-therapeutic-index">Novel T-cell engager AZD-9793 has improved therapeutic index</a></h1><div class="featured-stories__teaser">Researchers from Astrazeneca plc presented the discovery and preclinical characterization of AZD-9793, a novel CD8-guided T-cell engager (TCE) being developed for the treatment of hepatocellular carcinoma (HCC).</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714827-secretome-raises-funding-for-stm-01-in-heart-failure-cardiomyopathy">Secretome raises funding for STM-01 in heart failure, cardiomyopathy</a></h1><div class="featured-stories__teaser">Secretome Therapeutics Inc. has closed a $20.4 million round of financing to support its development of therapies derived from neonatal cardiac progenitor cells. </div></article> </li> </ul> </section></div><div class="news-service articles-by-site-placement-tax"><section class="featured-stories-by-site-placement__wrapper"><section class="featured-stories-by-site-placement "> <div class="featured-stories-by-site-placement__items-wrapper"><ul class="featured-stories-by-site-placement__items featured-stories-by-site-placement__items-1"> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714828-enanta-pharmaceuticals-expands-immunology-portfolio">Enanta Pharmaceuticals expands immunology portfolio</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/714828-enanta-pharmaceuticals-expands-immunology-portfolio" href="https://www.bioworld.com/articles/714828-enanta-pharmaceuticals-expands-immunology-portfolio"><img class="featured-stories-by-site-placement__image-thumb" alt="Close up image of shoulder and back with severe urticaria or hives " title="Close up image of shoulder and back with severe urticaria or hives " width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Dermatologic/Uticaria-hives-rash.jpg?height=146&t=1722372681&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714835-daewoong-pharmaceutical-divulges-new-pol-inhibitors">Daewoong Pharmaceutical divulges new POLθ inhibitors</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714836-researchers-in-spain-describe-new-trex2-inhibitors">Researchers in Spain describe new TREX2 inhibitors</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714829-empyrean-therapeutics-acquires-tlr2-antagonist-from-eos-therapies">Empyrean Therapeutics acquires TLR2 antagonist from Eos Therapies</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/714829-empyrean-therapeutics-acquires-tlr2-antagonist-from-eos-therapies" href="https://www.bioworld.com/articles/714829-empyrean-therapeutics-acquires-tlr2-antagonist-from-eos-therapies"><img class="featured-stories-by-site-placement__image-thumb" alt="Futuristic drug capsule" title="Futuristic drug capsule" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Futuristic-drug-capsule.jpg?height=146&t=1732639539&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714837-new-mrgprx2-antagonists-disclosed-in-septurna-patent">New MRGPRX2 antagonists disclosed in Septurna patent</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714838-shandong-luye-pharmaceutical-discovers-new-gnrhr-antagonists">Shandong Luye Pharmaceutical discovers new GNRHR antagonists</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714830-loss-of-function-variants-linked-to-neurodevelopmental-disorder-with-hypercholanemia">Loss-of-function variants linked to neurodevelopmental disorder with hypercholanemia</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/714830-loss-of-function-variants-linked-to-neurodevelopmental-disorder-with-hypercholanemia" href="https://www.bioworld.com/articles/714830-loss-of-function-variants-linked-to-neurodevelopmental-disorder-with-hypercholanemia"><img class="featured-stories-by-site-placement__image-thumb" alt="Drug discovery illustration" title="Drug discovery illustration" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Drug-research-illustration.jpg?height=146&t=1711382891&width=193" /></a></figure></div></article> </li> </ul></div> </section></section></div></section><div class="topic-podcast"><div> <a href="https://clarivate.com/life-sciences-healthcare/bioworld/order/" target="_blank"><img src="https://www.bioworld.com/ext/resources/Ads/2024/Focus-25-EOY-offer2.jpg"></a></div><section class="bioworld-podcasts-component"><div class="bioworld-podcasts-component__wrapper"><div class="bioworld-podcasts-component__content"><h3 class="bioworld-podcasts-component__headline"><a class="bioworld-podcasts-component__headline-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women">BioWorld Insider Podcast</a></h3><div class="bioworld-podcasts-component__body"><img src="https://www.bioworld.com/ext/resources/Podcast-files/play-circle-button.png?1718131949" style="display: inline-block; vertical-align: bottom; margin: 5px 0px 5px 5px; text-align: right; float: right; max-width: calc(100% - 5px); width: 95px;" alt="Play button" data-uuid="YTAtMTE1OTM1" align="right">Karen Carey, <em>BioWorld</em>’s managing editor and chief analyst, and the managing editor of <em>Bioworld Science</em>, Anette Breindl, join this episode of the <em>BioWorld Insider</em> podcast to talk about the business and the science of women’s health.</div><a class="bioworld-podcasts-component__link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women">Listen now</a></div></div></section></div><section class="topics-section__wrapper"><div class="topics-section__primary"><section class="topics-section "> <h1 class="topics-section__title"><a class="topics-section__title-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-title" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">Conferences</a></h1><ul class="topics-section__items"> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/714755-cgt-6297-leads-to-tumor-regression-in-breast-cancer-model" href="https://www.bioworld.com/articles/714755-cgt-6297-leads-to-tumor-regression-in-breast-cancer-model"><img class="topics-section__image-thumb" alt="Cancer tumor in breast illustration" title="Cancer tumor in breast illustration" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/breast-cancer-wireframe.jpg?height=355&t=1706887459&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714755-cgt-6297-leads-to-tumor-regression-in-breast-cancer-model">CGT-6297 leads to tumor regression in breast cancer model</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/155,520">AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics</a></div><div class="topics-section__teaser">Researchers from Cogent Biosciences Inc. have presented data on their PI3KA H1047R mutant inhibitor CGT-6297 PI3KA wild-type inhibitors can lead to toxicity issues such as hyperglycemia, gastrointestinal toxicity and skin reactions.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/714752-collagen-receptor-uparap-targeted-adcs-are-active-in-sarcoma-models" href="https://www.bioworld.com/articles/714752-collagen-receptor-uparap-targeted-adcs-are-active-in-sarcoma-models"><img class="topics-section__image-thumb" alt="Light micrograph of fibrosarcoma, a type of soft tissue sarcoma" title="Light micrograph of fibrosarcoma, a type of soft tissue sarcoma" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Fibrosarcoma-soft-tissue-sarcoma.jpg?height=355&t=1732551251&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714752-collagen-receptor-uparap-targeted-adcs-are-active-in-sarcoma-models">Collagen receptor uPARAP-targeted ADCs are active in sarcoma models</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="topics-section__teaser">Researchers from KU Leuven presented novel urokinase plasminogen activator receptor-associated protein (uPARAP)-targeted antibody-drug conjugates (ADC), ADCE-017 and ADCE-202, being developed for the treatment of soft tissue sarcoma.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714749-co-005-is-potent-new-anti-cd47-fusion-protein">CO-005 is potent new anti-CD47 fusion protein</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="topics-section__teaser">Researchers from Caedo Oncology AS presented the discovery and preclinical characterization of CO-005, a novel anti-CD47 fusion protein being developed for the treatment of lymphoma.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/714750-db-2304-has-strong-in-vivo-potency-in-psoriasis-models" href="https://www.bioworld.com/articles/714750-db-2304-has-strong-in-vivo-potency-in-psoriasis-models"><img class="topics-section__image-thumb" alt="Doctor holding illustration of cross section of skin" title="Doctor holding illustration of cross section of skin" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Dermatology-skin-layer-doctor.jpg?height=355&t=1732551251&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714750-db-2304-has-strong-in-vivo-potency-in-psoriasis-models">DB-2304 has strong in vivo potency in psoriasis models</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/162,520">American College of Rheumatology</a></div><div class="topics-section__teaser">Blood dendritic cell antigen 2 (BDCA2) is expressed in plasmacytoid dendritic cells. These cells’ overproduction of type I interferon is closely linked to the pathogenesis of systemic lupus erythematosus and other autoimmune diseases.</div></div></article> </li> </ul><a class="topics-section__more-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-more-link" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">More in Conferences</a> </section></div><div class="topics-section__aside"><section class="news-in-brief "> <h1 class="news-in-brief__title">Today's news in brief</h1><ul class="news-in-brief__items"> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/714761-other-news-to-note-for-nov-25-2024">Other news to note for Nov. 25, 2024</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689316-respiratory">Respiratory</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689317-dermatologic">Dermatologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689318-cardiovascular">Cardiovascular</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689319-hematologic">Hematologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689320-nephrology">Nephrology</a></h1></article> </li> </ul> </section></div></section><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/472-patents" href="/articles/topic/472-patents">Patents</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714758-hebei-wutu-pharmaceutical-divulges-new-trpv4-antagonists">Hebei Wutu Pharmaceutical divulges new TRPV4 antagonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714759-nanjing-mingde-new-drug-research-describes-new-nlrp3-inflammasome-inhibitors">Nanjing Mingde New Drug Research describes new NLRP3 inflammasome inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714757-beijing-danatlas-pharmaceutical-technology-patents-new-parg-inhibitors">Beijing Danatlas Pharmaceutical Technology patents new PARG inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714719-evotec-designs-new-47-antagonists">Evotec designs new α4β7 antagonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714718-roche-reports-cd73-inhibitors-for-cancer">Roche reports CD73 inhibitors for cancer</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714717-gruenenthal-describes-new-nociceptin-receptor-agonists-for-pain">Gruenenthal describes new nociceptin receptor agonists for pain</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714716-janssen-patent-discloses-new-compounds-for-mycobacterial-infections">Janssen patent discloses new compounds for mycobacterial infections</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714715-sanofi-patents-new-mapk7-inhibitors-for-cancer">Sanofi patents new MAPK7 inhibitors for cancer</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714609-horizon-omics-biotech-prepares-new-quinolone-derivatives">Horizon Omics Biotech prepares new quinolone derivatives</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714608-shanghai-synergy-and-zhejiang-huahai-synthesize-new-ccr4-antagonists">Shanghai Synergy and Zhejiang Huahai synthesize new CCR4 antagonists</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">Cancer</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/714840-radiopharma-telix-acquires-fap-targeting-agents-for-bladder-cancer" href="https://www.bioworld.com/articles/714840-radiopharma-telix-acquires-fap-targeting-agents-for-bladder-cancer"><img class="bioworld-biome__image-thumb" alt="Bladder cancer illustration" title="Bladder cancer illustration" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Bladder-cancer.png?height=355&t=1588879220&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714840-radiopharma-telix-acquires-fap-targeting-agents-for-bladder-cancer">Radiopharma Telix acquires FAP-targeting agents for bladder cancer </a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/214,520">Deals and M&A</a></div><div class="bioworld-biome__teaser">Radiopharmaceutical company Telix Pharmaceuticals Ltd. has inked a deal worth up to AU$264 million (US$171 million) to license and develop next-generation radiopharma imaging and therapy technology targeting fibroblast activation proteins found in a wide range of cancers.</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714754-j-ints-bios-jin-001-enhances-radiation-and-chemotherapy-to-treat-glioblastoma">J Ints Bio’s JIN-001 enhances radiation and chemotherapy to treat glioblastoma</a></h1></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714753-hemogenyx-gains-irb-approval-for-trial-of-hemo-car-t-for-aml">Hemogenyx gains IRB approval for trial of HEMO-CAR-T for AML</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/124,520">CAR T</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714751-origenis-oncobone-partner-for-cancer-bone-metastasis-assets">Origenis, Oncobone partner for cancer bone metastasis assets</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/217,520">Collaboration</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714747-series-b-financing-at-adcendo-to-fund-adc-pipeline">Series B financing at Adcendo to fund ADC pipeline </a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/269,520">Antibody-drug conjugate</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">More in Cancer</a> </section></div><div class="advertisement topics-section-2__col -two"><a href="https://clarivate.com/contact-us/sales-enquiries/" target="_blank"><img src="https://www.bioworld.com/ext/resources/Ads/2024/bioworld-advertising-reach.jpg" style="width: 300px; height: 250px;"></a></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">Infection</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article clinical--article"><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714727-edp-514-demonstrates-favorable-preclinical-pk-profile-excellent-target-tissue-penetration">EDP-514 demonstrates favorable preclinical PK profile, excellent target tissue penetration</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">Enanta Pharmaceuticals Inc. has released preclinical pharmacokinetics (PK) data for EDP-514, a potent and selective class II core assembly modulator in phase I development for the oral treatment of hepatitis B.</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714606-korea-research-institute-of-chemical-technology-and-novartis-identify-new-antiviral-compounds">Korea Research Institute of Chemical Technology and Novartis identify new antiviral compounds</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="clinical__teaser">A joint Korea Research Institute of Chemical Technology and Novartis AG patent describes antiviral 1,3-di-oxo-indene compounds reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease, diabetes, hepatitis A, viral infection, myocarditis, myositis and pancreatitis,...</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714601-epigenic-therapeutics-epigenetic-inactivator-cleared-to-enter-clinic-for-chronic-hepatitis-b">Epigenic Therapeutics’ epigenetic inactivator cleared to enter clinic for chronic hepatitis B</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/402,520">Regulatory</a></div><div class="clinical__teaser">Epigenic Therapeutics Inc. has received clinical trial application (CTA) approval from the New Zealand Medicines and Medical Devices Safety Authority (Medsafe) and the Health and Disability Ethics Committees (HDEC) to initiate a clinical trial for EPI-003, an investigational, liver-targeting...</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714579-gilead-discloses-gs-441524-prodrugs-for-treatment-of-viral-infections">Gilead discloses GS-441524 prodrugs for treatment of viral infections</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/472,520">Patents</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714475-greek-scientists-patent-new-spike-glycoprotein-ace2-interaction-inhibitors-for-sars-cov-2">Greek scientists patent new spike glycoprotein/ACE2 interaction inhibitors for SARS-CoV-2</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/517,520">Coronavirus</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714354-arcturus-gains-ind-clearance-for-h5n1-influenza-sa-rna-vaccine-candidate">Arcturus gains IND clearance for H5N1 influenza sa-RNA vaccine candidate</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/402,520">Regulatory</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714367-ifast-raises-65m-for-technology-to-fight-antimicrobial-resistance">Ifast raises $6.5M for technology to fight antimicrobial resistance</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/292,520">Financings</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">More in Infection</a> </section></div></div></section><div class="deals-m-a__wrapper"><section class="deals-m-a "> <h1 class="deals-m-a__title"><a class="deals-m-a__title-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-title" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">Neurology/psychiatric</a></h1><ul class="deals-m-a__items"> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/714745-in-muscular-dystrophies-gene-therapies-race-the-clock" href="https://www.bioworld.com/articles/714745-in-muscular-dystrophies-gene-therapies-race-the-clock"><img class="deals-m-a__image-thumb" alt="Illustration of man holding magnifying glass to human body model showing muscle anatomy" title="Illustration of man holding magnifying glass to human body model showing muscle anatomy" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Musculoskeletal/Muscle-anatomy-dna-research.jpg?height=355&t=1732551219&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714745-in-muscular-dystrophies-gene-therapies-race-the-clock">In muscular dystrophies, gene therapies race the clock</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/110,520">Science</a></div><div class="deals-m-a__teaser">Since the isolation of the gene that causes Duchenne muscular dystrophy (DMD), scientists have progressed in understanding the mechanisms that lead to muscular diseases that can be evident from the early stages of childhood. This has led to the development of diagnostics and therapeutics, some...</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714735-seed-funding-at-autoimmunity-biosolutions-to-advance-immuno-corrective-therapy-for-autoimmune-diseases">Seed funding at Autoimmunity Biosolutions to advance immuno-corrective therapy for autoimmune diseases</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/250,520">Immune</a></div><div class="deals-m-a__teaser">Autoimmunity Biosolutions has closed a seed financing to support its work advancing a next-generation, immuno-corrective therapy for autoimmune diseases. The company’s approach targets a branch of the interleukin-7 (IL-7)/interleukin-7 receptor (IL-7R) pathway controlled by the soluble IL-7R...</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/714730-rome-therapeutics-line-1-rt-inhibitors-show-neuroprotective-effect-in-parkinsons-disease-models" href="https://www.bioworld.com/articles/714730-rome-therapeutics-line-1-rt-inhibitors-show-neuroprotective-effect-in-parkinsons-disease-models"><img class="deals-m-a__image-thumb" alt="Hands holding brain" title="Hands holding brain" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/neurology-brain-protect.png?height=355&t=1589299362&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714730-rome-therapeutics-line-1-rt-inhibitors-show-neuroprotective-effect-in-parkinsons-disease-models">Rome Therapeutics’ LINE-1 RT inhibitors show neuroprotective effect in Parkinson’s disease models</a></h1><div class="deals-m-a__teaser">Rome Therapeutics Inc. has presented data demonstrating the potential of its LINE-1 reverse transcriptase (RT) inhibitors.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/714687-voyager-therapeutics-to-advance-tau-silencing-gene-therapy-for-alzheimers-disease" href="https://www.bioworld.com/articles/714687-voyager-therapeutics-to-advance-tau-silencing-gene-therapy-for-alzheimers-disease"><img class="deals-m-a__image-thumb" alt="Illustration of tau proteins in Alzheimer's disease" title="Illustration of tau proteins in Alzheimer's disease" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Alzheimer-disease-Tau-proteins.png?height=355&t=1678376665&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714687-voyager-therapeutics-to-advance-tau-silencing-gene-therapy-for-alzheimers-disease">Voyager Therapeutics to advance tau silencing gene therapy for Alzheimer’s disease</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/278,520">Gene therapy</a></div><div class="deals-m-a__teaser">Voyager Therapeutics Inc. has selected a lead development candidate, VY-1706, for its tau silencing gene therapy program in Alzheimer’s disease. The company anticipates filing an IND application with the FDA and a clinical trial application (CTA) with Health Canada for VY-1706 in 2026.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714605-aeovian-pharmaceuticals-patents-new-cd38-inhibitors">Aeovian Pharmaceuticals patents new CD38 inhibitors</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Aeovian Pharmaceuticals Inc. has prepared tricyclic fused imidazole compounds acting as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) inhibitors reported to be useful for the treatment of neurodegeneration, inflammation, fibrosis, systemic scleroderma and more.</div></div></article> </li> </ul><a 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arthritis symptoms in mice</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas">More than 100M cells included in the human cell atlas</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714607-hansoh-pharma-patent-develops-cfb-inhibitors">Hansoh Pharma patent develops CFB inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714520-research-supports-ccn1-as-a-therapeutic-target-in-rheumatoid-arthritis">Research supports CCN1 as a therapeutic target in rheumatoid arthritis</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714550-despite-womens-health-inroads-lackluster-funding-impedes-progress">Despite women’s health inroads, lackluster funding impedes progress</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714429-the-science-of-gender-based-medicine-many-reasons-many-manifestations">The science of gender-based medicine: many reasons, many manifestations</a></h1></article> 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href="https://www.bioworld.com/articles/714237-tonix-presents-new-data-on-tnx-801-mpox-vaccine">Tonix presents new data on TNX-801 mpox vaccine</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714202-oblenio-to-develop-tri-specific-t-cell-engager-for-autoimmune-diseases">Oblenio to develop tri-specific T-cell engager for autoimmune diseases</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">Endocrine/metabolic</a></h1><div 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regain</a></h1></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714695-new-preclinical-data-on-cvi-2742-for-treating-mash">New preclinical data on CVI-2742 for treating MASH</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714519-astrazeneca-exercises-option-for-type-1-diabetes-treg-cell-therapy-program-with-quell">Astrazeneca exercises option for type 1 diabetes Treg cell therapy program with Quell</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/225,520">License</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">More in Endocrine/metabolic</a> </section></div><div class="advertisement topics-section-2__col -two"><a href="https://clarivate.com/contact-us/sales-enquiries/" target="_blank"><img src="https://www.bioworld.com/ext/resources/Ads/2024/bioworld-advertising-audience.jpg" style="width: 300px; height: 250px;"></a></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">Biomarkers</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/714712-hoxb13-gene-involved-in-metastatic-omentum-carcinoma-study-shows" href="https://www.bioworld.com/articles/714712-hoxb13-gene-involved-in-metastatic-omentum-carcinoma-study-shows"><img class="clinical__image-thumb" alt="DNA mutations or genetic disorder concept art" title="DNA mutations or genetic disorder concept art" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/DNA-gene-damage-mutation.jpg?height=355&t=1711552096&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714712-hoxb13-gene-involved-in-metastatic-omentum-carcinoma-study-shows">HOXB13 gene involved in metastatic omentum carcinoma, study shows</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">Primary tumors arising in the gastrointestinal system, ovary or pancreas may spread and lead to secondary cancers such as metastatic omentum cancer.</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714570-novel-kdm3b-variant-found-in-atypical-diets-jongmans-case">Novel KDM3B variant found in atypical Diets-Jongmans case </a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">The <em>KDM3B</em> gene encodes the histone lysine demethylase lysine-specific demethylase 3B, which is involved in the regulation of transcription.</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714569-vsx2-variant-linked-to-retinal-detachment-risk">VSX2 variant linked to retinal detachment risk</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">Researchers from the U.K. have analyzed whole-genome sequencing data from 7,276 cases and 236,741 controls in the UK Biobank to perform gene-level and a variant-level exome-wide association study analysis to identify variants related to retinal 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class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714390-emgrhl2-em-emgrhl3-em-variants-tied-to-orofacial-clefting"><em>GRHL2</em>, <em>GRHL3</em> variants tied to orofacial clefting</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714357-emcasz1-em-found-as-possible-monogenic-cause-of-primary-aldosteronism"><em>CASZ1</em> found as possible monogenic cause of primary aldosteronism</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">More in Biomarkers</a> </section></div></div></section><section class="topics-section-3__wrapper"><div class="topics-section-3__col"><section class="regulatory "> <h1 class="regulatory__title"><a class="regulatory__title-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-title" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">Gastrointestinal</a></h1><ul class="regulatory__items"> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" 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There are no treatment options approved for ESLD, but, among others, regenerative therapies with...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714598-fap-inhibitor-azd-2389-improves-liver-fibrosis-and-mash">FAP inhibitor AZD-2389 improves liver fibrosis and MASH</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="regulatory__teaser">Astrazeneca plc has developed a potent oral fibroblast activation protein (FAP) inhibitor, AZD-2389, that avoids the cleavage of FGF21 and α2-AP. 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