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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89963562/Relationship_of_Circulating_Soluble_Urokinase_Plasminogen_Activator_Receptor_suPAR_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy"><img alt="Research paper thumbnail of Relationship of Circulating Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels to Disease Control in Asthma and Asthmatic Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/93658301/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89963562/Relationship_of_Circulating_Soluble_Urokinase_Plasminogen_Activator_Receptor_suPAR_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy">Relationship of Circulating Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels to Disease Control in Asthma and Asthmatic Pregnancy</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2bd7fcfbb5c578b422c04f7c3efeb1a6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93658301,"asset_id":89963562,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93658301/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89963562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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$('.js-work-strip[data-work-id=89963562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89963562,"title":"Relationship of Circulating Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels to Disease Control in Asthma and Asthmatic Pregnancy","translated_title":"","metadata":{"publisher":"Public Library of Science (PLoS)","grobid_abstract":"Asthma has a high burden of morbidity if not controlled and may frequently complicate pregnancy, posing a risk for pregnancy outcomes. Elevated plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is related to a worse prognosis in many conditions such as infectious, autoimmune, or pregnancy-related diseases; however the value of suPAR in asthma and asthmatic pregnancy is unknown. The present study aimed to investigate the suPAR, CRP and IL-6 levels in asthma (asthmatic non-pregnant, ANP; N = 38; female N = 27) and asthmatic pregnancy (AP; N = 15), compared to healthy non-pregnant controls (HNP; N = 29; female N = 19) and to healthy pregnant women (HP; N = 58). The relationship between suPAR levels and asthma control was also evaluated. The diagnostic efficacy of suPAR in asthma control was analyzed using ROC analysis. IL-6 and CRP levels were comparable in all study groups. Circulating suPAR levels were lower in HP and AP than in HNP and ANP subjects, respectively (2.01 [1.81-2.38] and 2.39 [2.07-2.69] vs. 2.60 [1.82-3.49] and 2.84 [2.33-3.72] ng/mL, respectively, p = 0.0001). suPAR and airway resistance correlated in ANP (r = 0.47, p = 0.004). ROC analysis of suPAR values in ANP patients with PEF above and below 80% yielded an AUC of 0.75 (95% CI: 0.57-0.92, p = 0.023) and with ACT total score above and below 20 an AUC of 0.80 (95% CI: 0.64-0.95, p = 0.006). The cutoff value of suPAR to discriminate between controlled and not controlled AP and ANP was 4.04 ng/mL. In conclusion, suPAR may help the objective assessment of asthma control, since it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control. Decrease in circulating suPAR levels detected both in healthy and asthmatic pregnant women presumably represents pregnancy induced immune tolerance.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":93658301},"translated_abstract":null,"internal_url":"https://www.academia.edu/89963562/Relationship_of_Circulating_Soluble_Urokinase_Plasminogen_Activator_Receptor_suPAR_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_internal_url":"","created_at":"2022-11-04T07:28:20.574-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93658301,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93658301/thumbnails/1.jpg","file_name":"e4de18d4dc5e911980fe3bc06a614ff7f755.pdf","download_url":"https://www.academia.edu/attachments/93658301/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Soluble_Urok.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93658301/e4de18d4dc5e911980fe3bc06a614ff7f755-libre.pdf?1667591359=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Soluble_Urok.pdf\u0026Expires=1732749062\u0026Signature=NMt8sehz3CVDsGJanypUi2J8Ea9FKsGBpfrCjZp2rXv5A7mwjymj~rSEPQr5JTWEhQeKgU~YA9u7EBhiGmD9g3zBGkBVvoZ313kD~2LG3webjnQN8jkIg9bSla1RKcUbRZ6sandDE4KtglJNPWKPAzr~9~07AHPC6udaRLpwV~tskklYlaGB1wJ7bn-0DybznGUO0J8k6wvhJhA0U1bTPd3uZ-ND-A6fqLl3~kbtym7w6Z5K~HltbwThRhvpIFO7jEZexQgNtARDlUZ4s3dslLU4PX-AWkWfy4sY8OxcNHKY~b8PF3bZyu0CAOU8g7o7xXxkERHB3b9jm6-OK-XVfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Relationship_of_Circulating_Soluble_Urokinase_Plasminogen_Activator_Receptor_suPAR_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":93658301,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93658301/thumbnails/1.jpg","file_name":"e4de18d4dc5e911980fe3bc06a614ff7f755.pdf","download_url":"https://www.academia.edu/attachments/93658301/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Soluble_Urok.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93658301/e4de18d4dc5e911980fe3bc06a614ff7f755-libre.pdf?1667591359=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Soluble_Urok.pdf\u0026Expires=1732749062\u0026Signature=NMt8sehz3CVDsGJanypUi2J8Ea9FKsGBpfrCjZp2rXv5A7mwjymj~rSEPQr5JTWEhQeKgU~YA9u7EBhiGmD9g3zBGkBVvoZ313kD~2LG3webjnQN8jkIg9bSla1RKcUbRZ6sandDE4KtglJNPWKPAzr~9~07AHPC6udaRLpwV~tskklYlaGB1wJ7bn-0DybznGUO0J8k6wvhJhA0U1bTPd3uZ-ND-A6fqLl3~kbtym7w6Z5K~HltbwThRhvpIFO7jEZexQgNtARDlUZ4s3dslLU4PX-AWkWfy4sY8OxcNHKY~b8PF3bZyu0CAOU8g7o7xXxkERHB3b9jm6-OK-XVfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":47155,"name":"Birth Weight","url":"https://www.academia.edu/Documents/in/Birth_Weight"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":234864,"name":"Urokinase","url":"https://www.academia.edu/Documents/in/Urokinase"},{"id":295452,"name":"C reactive protein","url":"https://www.academia.edu/Documents/in/C_reactive_protein"},{"id":338534,"name":"Biomarker","url":"https://www.academia.edu/Documents/in/Biomarker"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"}],"urls":[{"id":25537743,"url":"http://dx.plos.org/10.1371/journal.pone.0060697"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="82548734"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/82548734/Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy"><img alt="Research paper thumbnail of Relationship of Circulating Hyaluronic Acid Levels to Disease Control in Asthma and Asthmatic Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/88225469/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/82548734/Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy">Relationship of Circulating Hyaluronic Acid Levels to Disease Control in Asthma and Asthmatic Pregnancy</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="20e71d96efe421b242651d2e36a83407" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":88225469,"asset_id":82548734,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/88225469/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="82548734"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="82548734"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 82548734; 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Hyaluronic acid (HA), a potential peripheral blood marker of tissue fibrosis in various diseases, promotes eosinophil survival and plays a role in asthmatic airway inflammation as well as in physiological processes necessary to maintain normal pregnancy; however the level of circulating HA in asthma and asthmatic pregnancy is unknown. We investigated HA levels in asthmatic patients (N = 52; asthmatic pregnant (AP) N = 16; asthmatic non-pregnant (ANP) N = 36) and tested their relationship to asthma control. Serum HA level was lower in AP than in ANP patients (27 [24.7-31.55] vs. 37.4 [30.1-66.55] ng/mL, p = 0.006); the difference attenuated to a trend after its adjustment for patients' age (p = 0.056). HA levels and airway resistance were positively (r = 0.467, p = 0.004), HA levels and Asthma Control Test (ACT) total score inversely (r = 20.437, p = 0.01) associated in ANP patients; these relationships remained significant even after their adjustments for age. The potential value of HA in the determination of asthma control was analyzed using ROC analysis which revealed that HA values discriminate patients with ACT total score $20 (controlled patients) and ,20 (uncontrolled patients) with a 0.826 efficacy (AUC, 95% CI: 0.69-0.97, p = 0.001) when 37.4 ng/mL is used as cutoff value in ANP group, and with 0.78 efficacy (AUC, 95% CI: 0.65-0.92, p = 0.0009) in the whole asthmatic cohort. In conclusion circulating HA might be a marker of asthma control, as it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control. Decrease of HA level in pregnancy may be the consequence of pregnancy induced immune tolerance.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":88225469},"translated_abstract":null,"internal_url":"https://www.academia.edu/82548734/Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_internal_url":"","created_at":"2022-07-04T10:34:29.944-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":88225469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/88225469/thumbnails/1.jpg","file_name":"9569805937af1f470c75f3a378540034f808.pdf","download_url":"https://www.academia.edu/attachments/88225469/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Hyaluronic_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/88225469/9569805937af1f470c75f3a378540034f808-libre.pdf?1656958308=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Hyaluronic_A.pdf\u0026Expires=1732749062\u0026Signature=QJhcKqLIb-V3g-Bz3eyqP6eILLwcPeExxeTN0mPGhSqtoqURPmyHMjpWFu7vUsYQdLFfNRYLYvuxwum-Ym18B2AmALtYq2fRr8~MSc0~mRGpfzN4hy-QvaTFKb6zWGpTfvBTHgNlgi6pJgvcstdIx2guNqE4CfB~RrSLR0gUZGSOwA4F4Fq6AxO1CiNIkXaR4DpSldK93Y1eU2RnEcX~XPzVbITe4KspfqF1f0f54fXKLIKQXRbqJxciii~xk-twBW0u1L8dkL52UbcKGIr1ik~AF042OR2ILEHzshNclXxsGcxgdx6o0N5bpm9N2Y0lX5h4ObdgDmnUVyi~lOrX~w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":88225469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/88225469/thumbnails/1.jpg","file_name":"9569805937af1f470c75f3a378540034f808.pdf","download_url":"https://www.academia.edu/attachments/88225469/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Hyaluronic_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/88225469/9569805937af1f470c75f3a378540034f808-libre.pdf?1656958308=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Hyaluronic_A.pdf\u0026Expires=1732749062\u0026Signature=QJhcKqLIb-V3g-Bz3eyqP6eILLwcPeExxeTN0mPGhSqtoqURPmyHMjpWFu7vUsYQdLFfNRYLYvuxwum-Ym18B2AmALtYq2fRr8~MSc0~mRGpfzN4hy-QvaTFKb6zWGpTfvBTHgNlgi6pJgvcstdIx2guNqE4CfB~RrSLR0gUZGSOwA4F4Fq6AxO1CiNIkXaR4DpSldK93Y1eU2RnEcX~XPzVbITe4KspfqF1f0f54fXKLIKQXRbqJxciii~xk-twBW0u1L8dkL52UbcKGIr1ik~AF042OR2ILEHzshNclXxsGcxgdx6o0N5bpm9N2Y0lX5h4ObdgDmnUVyi~lOrX~w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":300179,"name":"Hyaluronic Acid","url":"https://www.academia.edu/Documents/in/Hyaluronic_Acid"},{"id":3298155,"name":"Pregnancy complications","url":"https://www.academia.edu/Documents/in/Pregnancy_complications"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088241"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088241/Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis"><img alt="Research paper thumbnail of Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at the time of diagnosis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088241/Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis">Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at the time of diagnosis</a></div><div class="wp-workCard_item"><span>Lung cancer</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infecti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infections influence tumor genesis and anticancer therapy in several organs. As data on lower respiratory tract infection (LRTI) and lung cancer outcome are scarce our objective was to determine potential role of LRTI on one-year mortality and its effect on therapeutic possibilities in patients with pulmonary malignancies. All patients diagnosed in 2017 who had bronchoscopic microbial sampling at the time of lung cancer diagnosis (N=143) were included. Group 1 (LRTI+) included patients with confirmed LRTI (N=74) and Group 2 (LRTI-) with no infection (N=69). Clinical characteristics, pathogen profile and one-year survival was analyzed. Age, gender, TNM, stage, histology type, comorbidities or underlying lung disease did not differ among groups. Performance status 0 was significantly less common in Group 1 (LRTI+), while significantly increased neutrophil/lymphocyte ratio was observed. Most common LRTI pathogens included aerobic (N=49), anaerobic (N=14) and fungal (N=26) infections. Chemo/immune/target therapy alone or in combination with radiotherapy were significantly less common in Group 1 (LRTI+) and more patients were only eligible for palliative care. Group 1 patients with LRTI of multiple pathogens compared to single pathogen infection were significantly older, had less frequently adenocarcinoma and had worse performance status. One-year median survival for all patients was 274 days (235 vs. 305 days Group 1 vs Group 2). LRTI is associated with lower one-year median survival of pulmonary malignancy patients, especially in patients with multiple pathogen infections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088241"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088241"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088241; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088241]").text(description); $(".js-view-count[data-work-id=73088241]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088241; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088241']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088241, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088241]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088241,"title":"Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at the time of diagnosis","translated_title":"","metadata":{"abstract":"Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infections influence tumor genesis and anticancer therapy in several organs. As data on lower respiratory tract infection (LRTI) and lung cancer outcome are scarce our objective was to determine potential role of LRTI on one-year mortality and its effect on therapeutic possibilities in patients with pulmonary malignancies. All patients diagnosed in 2017 who had bronchoscopic microbial sampling at the time of lung cancer diagnosis (N=143) were included. Group 1 (LRTI+) included patients with confirmed LRTI (N=74) and Group 2 (LRTI-) with no infection (N=69). Clinical characteristics, pathogen profile and one-year survival was analyzed. Age, gender, TNM, stage, histology type, comorbidities or underlying lung disease did not differ among groups. Performance status 0 was significantly less common in Group 1 (LRTI+), while significantly increased neutrophil/lymphocyte ratio was observed. Most common LRTI pathogens included aerobic (N=49), anaerobic (N=14) and fungal (N=26) infections. Chemo/immune/target therapy alone or in combination with radiotherapy were significantly less common in Group 1 (LRTI+) and more patients were only eligible for palliative care. Group 1 patients with LRTI of multiple pathogens compared to single pathogen infection were significantly older, had less frequently adenocarcinoma and had worse performance status. One-year median survival for all patients was 274 days (235 vs. 305 days Group 1 vs Group 2). LRTI is associated with lower one-year median survival of pulmonary malignancy patients, especially in patients with multiple pathogen infections.","publisher":"European Respiratory Society","publication_name":"Lung cancer"},"translated_abstract":"Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infections influence tumor genesis and anticancer therapy in several organs. As data on lower respiratory tract infection (LRTI) and lung cancer outcome are scarce our objective was to determine potential role of LRTI on one-year mortality and its effect on therapeutic possibilities in patients with pulmonary malignancies. All patients diagnosed in 2017 who had bronchoscopic microbial sampling at the time of lung cancer diagnosis (N=143) were included. Group 1 (LRTI+) included patients with confirmed LRTI (N=74) and Group 2 (LRTI-) with no infection (N=69). Clinical characteristics, pathogen profile and one-year survival was analyzed. Age, gender, TNM, stage, histology type, comorbidities or underlying lung disease did not differ among groups. Performance status 0 was significantly less common in Group 1 (LRTI+), while significantly increased neutrophil/lymphocyte ratio was observed. Most common LRTI pathogens included aerobic (N=49), anaerobic (N=14) and fungal (N=26) infections. Chemo/immune/target therapy alone or in combination with radiotherapy were significantly less common in Group 1 (LRTI+) and more patients were only eligible for palliative care. Group 1 patients with LRTI of multiple pathogens compared to single pathogen infection were significantly older, had less frequently adenocarcinoma and had worse performance status. One-year median survival for all patients was 274 days (235 vs. 305 days Group 1 vs Group 2). LRTI is associated with lower one-year median survival of pulmonary malignancy patients, especially in patients with multiple pathogen infections.","internal_url":"https://www.academia.edu/73088241/Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis","translated_internal_url":"","created_at":"2022-03-05T01:51:10.782-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51698,"name":"Lung Cancer","url":"https://www.academia.edu/Documents/in/Lung_Cancer"}],"urls":[{"id":18260899,"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2019.PA4666"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088240"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088240/Central_European_idiopathic_pulmonary_fibrosis_IPF_patients_survey"><img alt="Research paper thumbnail of Central European idiopathic pulmonary fibrosis (IPF) patients survey" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088240/Central_European_idiopathic_pulmonary_fibrosis_IPF_patients_survey">Central European idiopathic pulmonary fibrosis (IPF) patients survey</a></div><div class="wp-workCard_item"><span>Idiopathic interstitial pneumonias</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088240"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088240"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088240; 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Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results: The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.","publication_name":"Respiratory Research","grobid_abstract_attachment_id":81747766},"translated_abstract":null,"internal_url":"https://www.academia.edu/73088239/Genetic_influences_on_the_onset_of_obstructive_sleep_apnoea_and_daytime_sleepiness_a_twin_study","translated_internal_url":"","created_at":"2022-03-05T01:51:10.390-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81747766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747766/thumbnails/1.jpg","file_name":"s12931-019-1095-x.pdf","download_url":"https://www.academia.edu/attachments/81747766/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_influences_on_the_onset_of_obstr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747766/s12931-019-1095-x-libre.pdf?1646475987=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_influences_on_the_onset_of_obstr.pdf\u0026Expires=1732749062\u0026Signature=NZA8ZTUSLdOBmdJ5ehZMmJuIkH949gLiqAT36PJwFUlAXhsjN2X09iLpKMGASU6AmkxhG2goiRSbufUycwr-dO1pMIS9EtvfDr0c27PZqqJAQFCg5yoh9n7D9UqCzjHBELAszCGK-2PB3Oo7jY27ifKCxzyEgOMbN5ibB-MmWLbsEI6gnCn-OYz9F4vNuKWMR3r1s8s3RW5YfZSb1KciJdHtWKsm-bzcOVrbVyOvO46MedgLKxZnIBm-v9TAx0rNCTQezMPPSzYh73sMKEqEIjxE1lEyl3vmB0moimKiEiae2kbINb8Xji9mTGui1zhLQPXy0lz8eXW357leNEStuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Genetic_influences_on_the_onset_of_obstructive_sleep_apnoea_and_daytime_sleepiness_a_twin_study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":81747766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747766/thumbnails/1.jpg","file_name":"s12931-019-1095-x.pdf","download_url":"https://www.academia.edu/attachments/81747766/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_influences_on_the_onset_of_obstr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747766/s12931-019-1095-x-libre.pdf?1646475987=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_influences_on_the_onset_of_obstr.pdf\u0026Expires=1732749062\u0026Signature=NZA8ZTUSLdOBmdJ5ehZMmJuIkH949gLiqAT36PJwFUlAXhsjN2X09iLpKMGASU6AmkxhG2goiRSbufUycwr-dO1pMIS9EtvfDr0c27PZqqJAQFCg5yoh9n7D9UqCzjHBELAszCGK-2PB3Oo7jY27ifKCxzyEgOMbN5ibB-MmWLbsEI6gnCn-OYz9F4vNuKWMR3r1s8s3RW5YfZSb1KciJdHtWKsm-bzcOVrbVyOvO46MedgLKxZnIBm-v9TAx0rNCTQezMPPSzYh73sMKEqEIjxE1lEyl3vmB0moimKiEiae2kbINb8Xji9mTGui1zhLQPXy0lz8eXW357leNEStuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81747767,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747767/thumbnails/1.jpg","file_name":"s12931-019-1095-x.pdf","download_url":"https://www.academia.edu/attachments/81747767/download_file","bulk_download_file_name":"Genetic_influences_on_the_onset_of_obstr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747767/s12931-019-1095-x-libre.pdf?1646475986=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_influences_on_the_onset_of_obstr.pdf\u0026Expires=1732749062\u0026Signature=cqi6LuoVKgyVW7PX8mvKr7ZR0BlDVfAudl18xscQNAn4XIBmIQNzCD4V43yBTTQ1df8OHcgIu17JPHC0q4VpiHCyzwyW6ZjmRYaQ~g~tEs6wCY8w0Uuci1Z0oj0hIXHFA1K7NPdk6IHK89r9Jm1fLrH0-mBRjnIJCyAqIHJJ3WLj4uG2~ee0sYYP7f0YSMWIxuKPvUvaEw3-mgh-RqNHkb6yq-slhtpgJQRcCvGq8ifS2FO-2yIxL7jEE6pFwn1qNbiGuFTj3JZ3MQpPPjuVY98~Uu1P4ukGmqnaZ-0oTcdBcx8bO3ZMCcUY72IrokRR7X62kp1E5CggFC9bS-IWEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":400071,"name":"Respiratory","url":"https://www.academia.edu/Documents/in/Respiratory"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":18260897,"url":"http://link.springer.com/content/pdf/10.1186/s12931-019-1095-x.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088238"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088238/Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma"><img alt="Research paper thumbnail of Relationship between HRCT changes and clinical parameters in patients with scleroderma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088238/Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma">Relationship between HRCT changes and clinical parameters in patients with scleroderma</a></div><div class="wp-workCard_item"><span>Imaging</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degenerat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degeneration of the connective tissue in the lung, which is one of the most frequently involved organ related to this process. The extent of the lung involvement can be assessed in the high resolution CT (HRCT), which has important relevance in the prognosis and therapy. The aim of this study was to assess the relationship between visible changes in the HRCT and clinical parameters such as lung function and serology. Methods: 34 SS patients with abnormal lung functions or X-ray images were selected to undergo an HRCT between January 2014 and September 2017. All HRCT image has been scored for the intensity of ground glass opacity (GGO), lung fibrosis, bronchiectasis and honeycombing. Additional parameters like vascular diameters and lung volume have been calculated. These radiological parameters have been compared to clinical parameters of the lung function (FVC, FEV1, TLCO, KLCO) and the serology (anti-nuclear antibody, ANA). Results: A significant association between morphological changes in the HRCT and lung volume was found (3919± 989 liters, p=0.011), as well as an association between the total lung volume and fibrosis (p=0.090). ANA showed a very strong correlation with GGOs (p=0.009) and a borderline correlation with the HRCT score (p=0.059). Conclusion: HRCT was a very useful method for the diagnosis of interstitial lung fibrosis in scleroderma patients. The lung volume was associated with the extension of interstitial lung disease and fibrosis. The extension of alveolitis showed association with ANA and HRCT score, therefore, it might be useful in the quantification of the disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088238"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088238"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088238; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088238]").text(description); $(".js-view-count[data-work-id=73088238]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088238; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088238']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088238, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088238]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088238,"title":"Relationship between HRCT changes and clinical parameters in patients with scleroderma","translated_title":"","metadata":{"abstract":"Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degeneration of the connective tissue in the lung, which is one of the most frequently involved organ related to this process. The extent of the lung involvement can be assessed in the high resolution CT (HRCT), which has important relevance in the prognosis and therapy. The aim of this study was to assess the relationship between visible changes in the HRCT and clinical parameters such as lung function and serology. Methods: 34 SS patients with abnormal lung functions or X-ray images were selected to undergo an HRCT between January 2014 and September 2017. All HRCT image has been scored for the intensity of ground glass opacity (GGO), lung fibrosis, bronchiectasis and honeycombing. Additional parameters like vascular diameters and lung volume have been calculated. These radiological parameters have been compared to clinical parameters of the lung function (FVC, FEV1, TLCO, KLCO) and the serology (anti-nuclear antibody, ANA). Results: A significant association between morphological changes in the HRCT and lung volume was found (3919± 989 liters, p=0.011), as well as an association between the total lung volume and fibrosis (p=0.090). ANA showed a very strong correlation with GGOs (p=0.009) and a borderline correlation with the HRCT score (p=0.059). Conclusion: HRCT was a very useful method for the diagnosis of interstitial lung fibrosis in scleroderma patients. The lung volume was associated with the extension of interstitial lung disease and fibrosis. The extension of alveolitis showed association with ANA and HRCT score, therefore, it might be useful in the quantification of the disease.","publisher":"European Respiratory Society","publication_name":"Imaging"},"translated_abstract":"Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degeneration of the connective tissue in the lung, which is one of the most frequently involved organ related to this process. The extent of the lung involvement can be assessed in the high resolution CT (HRCT), which has important relevance in the prognosis and therapy. The aim of this study was to assess the relationship between visible changes in the HRCT and clinical parameters such as lung function and serology. Methods: 34 SS patients with abnormal lung functions or X-ray images were selected to undergo an HRCT between January 2014 and September 2017. All HRCT image has been scored for the intensity of ground glass opacity (GGO), lung fibrosis, bronchiectasis and honeycombing. Additional parameters like vascular diameters and lung volume have been calculated. These radiological parameters have been compared to clinical parameters of the lung function (FVC, FEV1, TLCO, KLCO) and the serology (anti-nuclear antibody, ANA). Results: A significant association between morphological changes in the HRCT and lung volume was found (3919± 989 liters, p=0.011), as well as an association between the total lung volume and fibrosis (p=0.090). ANA showed a very strong correlation with GGOs (p=0.009) and a borderline correlation with the HRCT score (p=0.059). Conclusion: HRCT was a very useful method for the diagnosis of interstitial lung fibrosis in scleroderma patients. The lung volume was associated with the extension of interstitial lung disease and fibrosis. The extension of alveolitis showed association with ANA and HRCT score, therefore, it might be useful in the quantification of the disease.","internal_url":"https://www.academia.edu/73088238/Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma","translated_internal_url":"","created_at":"2022-03-05T01:51:10.216-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":6201,"name":"Imaging","url":"https://www.academia.edu/Documents/in/Imaging"}],"urls":[{"id":18260896,"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2018.PA859"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088237"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088237/Arterial_stiffness_measurement_on_lung_transplanted_patients"><img alt="Research paper thumbnail of Arterial stiffness measurement on lung transplanted patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088237/Arterial_stiffness_measurement_on_lung_transplanted_patients">Arterial stiffness measurement on lung transplanted patients</a></div><div class="wp-workCard_item"><span>Transplantation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088237"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088237"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088237; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088237]").text(description); $(".js-view-count[data-work-id=73088237]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088237; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088237']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088237, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088236"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088236/The_European_IPF_registry_eurIPFreg_baseline_characteristics_and_survival_of_patients_with_idiopathic_pulmonary_fibrosis"><img alt="Research paper thumbnail of The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/81747812/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088236/The_European_IPF_registry_eurIPFreg_baseline_characteristics_and_survival_of_patients_with_idiopathic_pulmonary_fibrosis">The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis</a></div><div class="wp-workCard_item"><span>Respiratory research</span><span>, Jul 28, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiologica...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The registry data are based on patient and physician baseline and follow-up questionnaires, comprising 1700 parameters. The mid- to long-term objectives of the registry are to provide clues for a better understanding of IPF phenotype sub-clusters, triggering factors and aggravating conditions, regional and environmental characteristics, and of disease behavior and management. This paper describes baseline data of 525 IPF subjects recruited from 11/2009 until 10/2016. IPF patients had a mean age of 68.1 years, and seeked medical advice due to insidious dyspnea (90.1%), fatigue (69.2%), and dry coughing (53.2%). A surgical lung biopsy was performed in 32% in 2009, but in only 8% of the cases in 2016, possibly due to increased numbers of cryobiopsy. At the time of inclusion in the eurIPFreg, FVC was 68.4% ± 22.6% of predicted value, DLco r...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4b57a327b1af37f8628075a608798c48" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747812,"asset_id":73088236,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747812/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088236"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088236"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088236; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088236]").text(description); $(".js-view-count[data-work-id=73088236]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088236; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088236']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088236, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4b57a327b1af37f8628075a608798c48" } } $('.js-work-strip[data-work-id=73088236]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088236,"title":"The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis","translated_title":"","metadata":{"abstract":"Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The registry data are based on patient and physician baseline and follow-up questionnaires, comprising 1700 parameters. The mid- to long-term objectives of the registry are to provide clues for a better understanding of IPF phenotype sub-clusters, triggering factors and aggravating conditions, regional and environmental characteristics, and of disease behavior and management. This paper describes baseline data of 525 IPF subjects recruited from 11/2009 until 10/2016. IPF patients had a mean age of 68.1 years, and seeked medical advice due to insidious dyspnea (90.1%), fatigue (69.2%), and dry coughing (53.2%). A surgical lung biopsy was performed in 32% in 2009, but in only 8% of the cases in 2016, possibly due to increased numbers of cryobiopsy. At the time of inclusion in the eurIPFreg, FVC was 68.4% ± 22.6% of predicted value, DLco r...","publication_date":{"day":28,"month":7,"year":2018,"errors":{}},"publication_name":"Respiratory research"},"translated_abstract":"Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The registry data are based on patient and physician baseline and follow-up questionnaires, comprising 1700 parameters. The mid- to long-term objectives of the registry are to provide clues for a better understanding of IPF phenotype sub-clusters, triggering factors and aggravating conditions, regional and environmental characteristics, and of disease behavior and management. This paper describes baseline data of 525 IPF subjects recruited from 11/2009 until 10/2016. IPF patients had a mean age of 68.1 years, and seeked medical advice due to insidious dyspnea (90.1%), fatigue (69.2%), and dry coughing (53.2%). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088235"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088235/Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy"><img alt="Research paper thumbnail of Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/81747811/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088235/Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy">Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy</a></div><div class="wp-workCard_item"><span>Canadian respiratory journal</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL,= 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml,= 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (= 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] g/mL,= 0.8730) and the level was lower in HP (98.80 [84.26-105.5] g/mL,= 0.0344 versus HNP). In contrast, the level was higher in AP ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3f4b7d66e18c277bbb3001ea7065c7ef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747811,"asset_id":73088235,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747811/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088235"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088235"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088235; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088235]").text(description); $(".js-view-count[data-work-id=73088235]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088235; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088235']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088235, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3f4b7d66e18c277bbb3001ea7065c7ef" } } $('.js-work-strip[data-work-id=73088235]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088235,"title":"Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy","translated_title":"","metadata":{"abstract":"Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL,= 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml,= 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (= 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] g/mL,= 0.8730) and the level was lower in HP (98.80 [84.26-105.5] g/mL,= 0.0344 versus HNP). In contrast, the level was higher in AP ...","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Canadian respiratory journal"},"translated_abstract":"Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL,= 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml,= 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (= 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] g/mL,= 0.8730) and the level was lower in HP (98.80 [84.26-105.5] g/mL,= 0.0344 versus HNP). In contrast, the level was higher in AP ...","internal_url":"https://www.academia.edu/73088235/Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy","translated_internal_url":"","created_at":"2022-03-05T01:51:09.741-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81747811,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747811/thumbnails/1.jpg","file_name":"1602039.pdf","download_url":"https://www.academia.edu/attachments/81747811/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Circulating_Clusterin_and_Osteopontin_Le.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747811/1602039-libre.pdf?1646475985=\u0026response-content-disposition=attachment%3B+filename%3DCirculating_Clusterin_and_Osteopontin_Le.pdf\u0026Expires=1732749062\u0026Signature=cnJ4~xCVxHjTOWTGje-zJDy0jZ4TYKUYP5Kfg9PGWYojOQEQ7hcGfrh9Xs39UeI19rnIKPKLxnufp1eS8LzeIfaDTDUD7cmuFLFs1aNaWdOTHt-s1S~m3vIafDLXz4XMo8~nflFVmWA-XoYl~jIOMZyc8tKZnVD1lYgs~H5EyQ-GzysGK-iitiOnOPeGlWa~YMLwvLpUS0YhuZWRlcBENIgLrZWU8UFgfxMDXbUUeS94DyPrr-9VEuR4VAkOU9BjCRhUgP18Tio2-8lUSDC7BO~a8nDrYw3nQ2iyPXraSJnW6SlOqvgJWMSv84rh~g0Vorv1ZI2YMTOMQjuAM9FMUA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":81747811,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747811/thumbnails/1.jpg","file_name":"1602039.pdf","download_url":"https://www.academia.edu/attachments/81747811/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Circulating_Clusterin_and_Osteopontin_Le.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747811/1602039-libre.pdf?1646475985=\u0026response-content-disposition=attachment%3B+filename%3DCirculating_Clusterin_and_Osteopontin_Le.pdf\u0026Expires=1732749062\u0026Signature=cnJ4~xCVxHjTOWTGje-zJDy0jZ4TYKUYP5Kfg9PGWYojOQEQ7hcGfrh9Xs39UeI19rnIKPKLxnufp1eS8LzeIfaDTDUD7cmuFLFs1aNaWdOTHt-s1S~m3vIafDLXz4XMo8~nflFVmWA-XoYl~jIOMZyc8tKZnVD1lYgs~H5EyQ-GzysGK-iitiOnOPeGlWa~YMLwvLpUS0YhuZWRlcBENIgLrZWU8UFgfxMDXbUUeS94DyPrr-9VEuR4VAkOU9BjCRhUgP18Tio2-8lUSDC7BO~a8nDrYw3nQ2iyPXraSJnW6SlOqvgJWMSv84rh~g0Vorv1ZI2YMTOMQjuAM9FMUA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088234"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088234/Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience"><img alt="Research paper thumbnail of Seasonal changes of lower respiratory tract infections in lung transplant recipients during the first post-transplant year: The Hungarian experience" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088234/Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience">Seasonal changes of lower respiratory tract infections in lung transplant recipients during the first post-transplant year: The Hungarian experience</a></div><div class="wp-workCard_item"><span>Transplant Infectious Disease</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejectio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejection of the graft. Together with earlier colonization by pathogens, immunosuppression makes recipients more susceptible to infections, especially during the first postoperative year. As seasonality of lower respiratory tract infections (LRTI) is well-known in chronic lung diseases, we assessed seasonal changes of pathogen spectrum and number of infections in the first postoperative year in LuTX recipients. LRTI were analyzed in 28 Hungarian adult LuTX patients. Incidence and spectrum of microorganism causing LRTI were evaluated according to post-transplant time and seasonal temperature and humidity changes. A total of 69 cases of LRTI were registered (average: 1.9 cases/patient; range: 0-14). Gram-negative=59, gram-positive=26, and fungal=31 pathogens were detected, with polymicrobial samples in 46% of all cases. Increased number of LRTI was observed in the cold season (1.68±1.54 vs 0.79±0.92 case/month/patient, P&amp;lt;.01) and significant negative correlations were identified between the incidence of polymicrobial and bacterial infections and temperature (r =0.1535, P&amp;lt;.05, r =0.3144, P&amp;lt;.01, respectively). In addition, positive correlation was observed between polymicrobial infections and humidity (r =0.1403, P&amp;lt;.05). Higher incidence of LRTI was also noted in the cold season, when accounting for the differences in immunosuppression. Seasons influenced the incidence of LRTI in the first postoperative year in LuTX recipients. More intensive vigilance for possible gram-negative and polymicrobial infections is needed in these patients in cold and wet seasons in the continental climate zone, regardless of underlying disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088234"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088234"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088234; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088234]").text(description); $(".js-view-count[data-work-id=73088234]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088234; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088234']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088234, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088234]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088234,"title":"Seasonal changes of lower respiratory tract infections in lung transplant recipients during the first post-transplant year: The Hungarian experience","translated_title":"","metadata":{"abstract":"After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejection of the graft. Together with earlier colonization by pathogens, immunosuppression makes recipients more susceptible to infections, especially during the first postoperative year. As seasonality of lower respiratory tract infections (LRTI) is well-known in chronic lung diseases, we assessed seasonal changes of pathogen spectrum and number of infections in the first postoperative year in LuTX recipients. LRTI were analyzed in 28 Hungarian adult LuTX patients. Incidence and spectrum of microorganism causing LRTI were evaluated according to post-transplant time and seasonal temperature and humidity changes. A total of 69 cases of LRTI were registered (average: 1.9 cases/patient; range: 0-14). Gram-negative=59, gram-positive=26, and fungal=31 pathogens were detected, with polymicrobial samples in 46% of all cases. Increased number of LRTI was observed in the cold season (1.68±1.54 vs 0.79±0.92 case/month/patient, P\u0026amp;lt;.01) and significant negative correlations were identified between the incidence of polymicrobial and bacterial infections and temperature (r =0.1535, P\u0026amp;lt;.05, r =0.3144, P\u0026amp;lt;.01, respectively). In addition, positive correlation was observed between polymicrobial infections and humidity (r =0.1403, P\u0026amp;lt;.05). Higher incidence of LRTI was also noted in the cold season, when accounting for the differences in immunosuppression. Seasons influenced the incidence of LRTI in the first postoperative year in LuTX recipients. More intensive vigilance for possible gram-negative and polymicrobial infections is needed in these patients in cold and wet seasons in the continental climate zone, regardless of underlying disease.","publisher":"Wiley-Blackwell","publication_name":"Transplant Infectious Disease"},"translated_abstract":"After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejection of the graft. Together with earlier colonization by pathogens, immunosuppression makes recipients more susceptible to infections, especially during the first postoperative year. As seasonality of lower respiratory tract infections (LRTI) is well-known in chronic lung diseases, we assessed seasonal changes of pathogen spectrum and number of infections in the first postoperative year in LuTX recipients. LRTI were analyzed in 28 Hungarian adult LuTX patients. Incidence and spectrum of microorganism causing LRTI were evaluated according to post-transplant time and seasonal temperature and humidity changes. A total of 69 cases of LRTI were registered (average: 1.9 cases/patient; range: 0-14). Gram-negative=59, gram-positive=26, and fungal=31 pathogens were detected, with polymicrobial samples in 46% of all cases. Increased number of LRTI was observed in the cold season (1.68±1.54 vs 0.79±0.92 case/month/patient, P\u0026amp;lt;.01) and significant negative correlations were identified between the incidence of polymicrobial and bacterial infections and temperature (r =0.1535, P\u0026amp;lt;.05, r =0.3144, P\u0026amp;lt;.01, respectively). In addition, positive correlation was observed between polymicrobial infections and humidity (r =0.1403, P\u0026amp;lt;.05). Higher incidence of LRTI was also noted in the cold season, when accounting for the differences in immunosuppression. Seasons influenced the incidence of LRTI in the first postoperative year in LuTX recipients. More intensive vigilance for possible gram-negative and polymicrobial infections is needed in these patients in cold and wet seasons in the continental climate zone, regardless of underlying disease.","internal_url":"https://www.academia.edu/73088234/Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience","translated_internal_url":"","created_at":"2022-03-05T01:51:09.497-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":81896,"name":"Hungary","url":"https://www.academia.edu/Documents/in/Hungary"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression"},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":444369,"name":"Humidity","url":"https://www.academia.edu/Documents/in/Humidity"},{"id":509782,"name":"Respiratory Tract Infections","url":"https://www.academia.edu/Documents/in/Respiratory_Tract_Infections"},{"id":587528,"name":"Bacterial infections","url":"https://www.academia.edu/Documents/in/Bacterial_infections"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":649451,"name":"Seasons","url":"https://www.academia.edu/Documents/in/Seasons"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1953423,"name":"Postoperative Period","url":"https://www.academia.edu/Documents/in/Postoperative_Period"},{"id":2731176,"name":"Lung Transplantation","url":"https://www.academia.edu/Documents/in/Lung_Transplantation"}],"urls":[{"id":18260894,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftid.12671"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088233"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088233/FP207GENDER_Dependent_Protective_Effect_of_Dhea_on_the_Hif_HSF_HSP_Axis_After_Renal_Ischemia_Reperfusion_Injury"><img alt="Research paper thumbnail of FP207GENDER Dependent Protective Effect of Dhea on the Hif-HSF-HSP Axis After Renal Ischemia/Reperfusion Injury" class="work-thumbnail" src="https://attachments.academia-assets.com/81747810/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088233/FP207GENDER_Dependent_Protective_Effect_of_Dhea_on_the_Hif_HSF_HSP_Axis_After_Renal_Ischemia_Reperfusion_Injury">FP207GENDER Dependent Protective Effect of Dhea on the Hif-HSF-HSP Axis After Renal Ischemia/Reperfusion Injury</a></div><div class="wp-workCard_item"><span>Nephrology Dialysis Transplantation</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="70f4f4156be57e17d813b804ab417cd3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747810,"asset_id":73088233,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747810/download_file?st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088233"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088233"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088233; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088232"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088232/Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients"><img alt="Research paper thumbnail of Bronchoalveolar lavage fluid leukotrienes in the pathomechanism of acute inflammatory events in lung transplant recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088232/Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients">Bronchoalveolar lavage fluid leukotrienes in the pathomechanism of acute inflammatory events in lung transplant recipients</a></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during the follow up of lung transplanted (LTx) patients is not fully understood. Leukotrienes, products of lipoxygenase enzyme may play a potential role, however they have not been investigated before. Aims: To analyse bronchoalveolar lavage fluid (BALF) leukotrienes in lung transplant recipients. Methods: Thirty-three BALF samples were analysed in 13 LTx patients for leukotriene B4 (LTB4) and cysteinyl-leukotriene (Cys-LT) concentration. In 10 cases patients were considered stable (stable group), in 7 cases bronchial biopsy revealed acute rejection (rejection group), and in 15 cases no sign of acute rejection, but a significant (&gt;10 3 CFU/ml) bacterial or fungal colony count was observed (infection group). Leukotrienes were determined with ELISA. Results: There was no difference in BALF total leukocyte number, lymphocyte, neutrophil or eosinophil cell count between the three groups, however a &gt;5% neutrophil count was indicative for infection. A tendency for higher BALF LTB4 was observed in acute rejection (341±445 pg/ml, p=0.05) as well as infection (156±163 pg/ml, p=0.09) compared to stable samples (66±57 pg/ml), without any difference between acute rejection and infection (p=0.52). BALF LTB4 levels were not related to lung function or BALF cell counts. No difference was shown for Cys-LT (p&gt;0.05). Conclusion: Our results indicate that LTB4 may play a role in the pathomechanism of acute inflammatory events in lung transplanted patients. This needs to be investigated in an extended cohort of patients in detail. The study was supported by Hungarian Respiratory Society grant.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088232"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088232"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088232; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088232]").text(description); $(".js-view-count[data-work-id=73088232]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088232; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088232']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088232, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088232]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088232,"title":"Bronchoalveolar lavage fluid leukotrienes in the pathomechanism of acute inflammatory events in lung transplant recipients","translated_title":"","metadata":{"abstract":"Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during the follow up of lung transplanted (LTx) patients is not fully understood. Leukotrienes, products of lipoxygenase enzyme may play a potential role, however they have not been investigated before. Aims: To analyse bronchoalveolar lavage fluid (BALF) leukotrienes in lung transplant recipients. Methods: Thirty-three BALF samples were analysed in 13 LTx patients for leukotriene B4 (LTB4) and cysteinyl-leukotriene (Cys-LT) concentration. In 10 cases patients were considered stable (stable group), in 7 cases bronchial biopsy revealed acute rejection (rejection group), and in 15 cases no sign of acute rejection, but a significant (\u0026gt;10 3 CFU/ml) bacterial or fungal colony count was observed (infection group). Leukotrienes were determined with ELISA. Results: There was no difference in BALF total leukocyte number, lymphocyte, neutrophil or eosinophil cell count between the three groups, however a \u0026gt;5% neutrophil count was indicative for infection. A tendency for higher BALF LTB4 was observed in acute rejection (341±445 pg/ml, p=0.05) as well as infection (156±163 pg/ml, p=0.09) compared to stable samples (66±57 pg/ml), without any difference between acute rejection and infection (p=0.52). BALF LTB4 levels were not related to lung function or BALF cell counts. No difference was shown for Cys-LT (p\u0026gt;0.05). Conclusion: Our results indicate that LTB4 may play a role in the pathomechanism of acute inflammatory events in lung transplanted patients. This needs to be investigated in an extended cohort of patients in detail. The study was supported by Hungarian Respiratory Society grant.","publisher":"European Respiratory Society","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"European Respiratory Journal"},"translated_abstract":"Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during the follow up of lung transplanted (LTx) patients is not fully understood. Leukotrienes, products of lipoxygenase enzyme may play a potential role, however they have not been investigated before. Aims: To analyse bronchoalveolar lavage fluid (BALF) leukotrienes in lung transplant recipients. Methods: Thirty-three BALF samples were analysed in 13 LTx patients for leukotriene B4 (LTB4) and cysteinyl-leukotriene (Cys-LT) concentration. In 10 cases patients were considered stable (stable group), in 7 cases bronchial biopsy revealed acute rejection (rejection group), and in 15 cases no sign of acute rejection, but a significant (\u0026gt;10 3 CFU/ml) bacterial or fungal colony count was observed (infection group). Leukotrienes were determined with ELISA. Results: There was no difference in BALF total leukocyte number, lymphocyte, neutrophil or eosinophil cell count between the three groups, however a \u0026gt;5% neutrophil count was indicative for infection. A tendency for higher BALF LTB4 was observed in acute rejection (341±445 pg/ml, p=0.05) as well as infection (156±163 pg/ml, p=0.09) compared to stable samples (66±57 pg/ml), without any difference between acute rejection and infection (p=0.52). BALF LTB4 levels were not related to lung function or BALF cell counts. No difference was shown for Cys-LT (p\u0026gt;0.05). Conclusion: Our results indicate that LTB4 may play a role in the pathomechanism of acute inflammatory events in lung transplanted patients. This needs to be investigated in an extended cohort of patients in detail. The study was supported by Hungarian Respiratory Society grant.","internal_url":"https://www.academia.edu/73088232/Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients","translated_internal_url":"","created_at":"2022-03-05T01:51:09.156-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088231"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088231/Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry"><img alt="Research paper thumbnail of Does early diagnosis of idiopathic pulmonary fibrosis matter? Real- world´s data from the EMPIRE registry" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088231/Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry">Does early diagnosis of idiopathic pulmonary fibrosis matter? Real- world´s data from the EMPIRE registry</a></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 year...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 years. Delay in diagnosis and treatment probably decreases a survival in IPF. Our study aims to investigate influence of time from the first symptoms to diagnosis on the survival. CONCLUSIONS: Our results show that earlier diagnosis and treatment may increase survival in IPF. Early diagnosis and treatment does matter in prognosis of IPF patients and thus maximal effort should be generated to get the patients diagnosed and treated as early as possible.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088231"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088231"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088231; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088231]").text(description); $(".js-view-count[data-work-id=73088231]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088231; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088231']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088231, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088231]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088231,"title":"Does early diagnosis of idiopathic pulmonary fibrosis matter? Real- world´s data from the EMPIRE registry","translated_title":"","metadata":{"abstract":"AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 years. Delay in diagnosis and treatment probably decreases a survival in IPF. Our study aims to investigate influence of time from the first symptoms to diagnosis on the survival. CONCLUSIONS: Our results show that earlier diagnosis and treatment may increase survival in IPF. Early diagnosis and treatment does matter in prognosis of IPF patients and thus maximal effort should be generated to get the patients diagnosed and treated as early as possible.","publisher":"European Respiratory Society","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"European Respiratory Journal"},"translated_abstract":"AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 years. Delay in diagnosis and treatment probably decreases a survival in IPF. Our study aims to investigate influence of time from the first symptoms to diagnosis on the survival. CONCLUSIONS: Our results show that earlier diagnosis and treatment may increase survival in IPF. Early diagnosis and treatment does matter in prognosis of IPF patients and thus maximal effort should be generated to get the patients diagnosed and treated as early as possible.","internal_url":"https://www.academia.edu/73088231/Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry","translated_internal_url":"","created_at":"2022-03-05T01:51:09.016-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088230"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088230/Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug"><img alt="Research paper thumbnail of Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088230/Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug">Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug</a></div><div class="wp-workCard_item"><span>European Journal of Pharmaceutical Sciences</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive pulmonary disease (COPD) management is Symbicort(®) Turbuhaler(®). The aim of this study was to simulate the deposition distribution of both components of this drug within the airways based on realistic airflow measurements. Breathing parameters of 25 healthy adults (11 females and 14 males) were acquired while inhaling through Turbuhaler(®). Individual specific emitted doses and particle size distributions of Symbicort(®) Turbuhaler(®) were determined. A self-developed particle deposition model was adapted and validated to simulate the deposition of budesonide (inhaled corticosteroid; ICS) and formoterol (long acting β2 agonist; LABA) in the upper airways and lungs of the healthy volunteers. Based on current simulations the emitted doses varied between 50.4% and 92.5% of the metered dose for the ICS, and between 38% and 96.1% in case of LABA component depending on the individual inhalation flow rate. This variability induced a notable inter-individual spread of the deposited lung doses (mean: 33.6%, range: 20.4%-48.8% for budesonide and mean: 29.8%, range: 16.4%-42.9% for formoterol). Significant inter-gender differences were also observed. Average lung dose of budesonide was 29.2% of the metered dose for females and 37% for males, while formoterol deposited with 26.4% efficiency for females and 32.5% for males. Present results also highlighted the importance of breath-holding after inhalation of the drug. About a half of the total lung deposition occurred during breath-hold at 9.6s average breath-hold time. Calculated depositions confirmed appropriate lung deposition of Symbicort(®) Turbuhaler(®) for both genders, however more effort for optimal inhalation technique is advised for persons with low vital capacity. This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations. The methodology developed in this study will be applicable also to other marketed drugs in the future.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088230"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088230"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088230; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088230]").text(description); $(".js-view-count[data-work-id=73088230]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088230; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088230']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088230, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088230]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088230,"title":"Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug","translated_title":"","metadata":{"abstract":"One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive pulmonary disease (COPD) management is Symbicort(®) Turbuhaler(®). The aim of this study was to simulate the deposition distribution of both components of this drug within the airways based on realistic airflow measurements. Breathing parameters of 25 healthy adults (11 females and 14 males) were acquired while inhaling through Turbuhaler(®). Individual specific emitted doses and particle size distributions of Symbicort(®) Turbuhaler(®) were determined. A self-developed particle deposition model was adapted and validated to simulate the deposition of budesonide (inhaled corticosteroid; ICS) and formoterol (long acting β2 agonist; LABA) in the upper airways and lungs of the healthy volunteers. Based on current simulations the emitted doses varied between 50.4% and 92.5% of the metered dose for the ICS, and between 38% and 96.1% in case of LABA component depending on the individual inhalation flow rate. This variability induced a notable inter-individual spread of the deposited lung doses (mean: 33.6%, range: 20.4%-48.8% for budesonide and mean: 29.8%, range: 16.4%-42.9% for formoterol). Significant inter-gender differences were also observed. Average lung dose of budesonide was 29.2% of the metered dose for females and 37% for males, while formoterol deposited with 26.4% efficiency for females and 32.5% for males. Present results also highlighted the importance of breath-holding after inhalation of the drug. About a half of the total lung deposition occurred during breath-hold at 9.6s average breath-hold time. Calculated depositions confirmed appropriate lung deposition of Symbicort(®) Turbuhaler(®) for both genders, however more effort for optimal inhalation technique is advised for persons with low vital capacity. This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations. The methodology developed in this study will be applicable also to other marketed drugs in the future.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"European Journal of Pharmaceutical Sciences"},"translated_abstract":"One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive pulmonary disease (COPD) management is Symbicort(®) Turbuhaler(®). The aim of this study was to simulate the deposition distribution of both components of this drug within the airways based on realistic airflow measurements. Breathing parameters of 25 healthy adults (11 females and 14 males) were acquired while inhaling through Turbuhaler(®). Individual specific emitted doses and particle size distributions of Symbicort(®) Turbuhaler(®) were determined. A self-developed particle deposition model was adapted and validated to simulate the deposition of budesonide (inhaled corticosteroid; ICS) and formoterol (long acting β2 agonist; LABA) in the upper airways and lungs of the healthy volunteers. Based on current simulations the emitted doses varied between 50.4% and 92.5% of the metered dose for the ICS, and between 38% and 96.1% in case of LABA component depending on the individual inhalation flow rate. This variability induced a notable inter-individual spread of the deposited lung doses (mean: 33.6%, range: 20.4%-48.8% for budesonide and mean: 29.8%, range: 16.4%-42.9% for formoterol). Significant inter-gender differences were also observed. Average lung dose of budesonide was 29.2% of the metered dose for females and 37% for males, while formoterol deposited with 26.4% efficiency for females and 32.5% for males. Present results also highlighted the importance of breath-holding after inhalation of the drug. About a half of the total lung deposition occurred during breath-hold at 9.6s average breath-hold time. Calculated depositions confirmed appropriate lung deposition of Symbicort(®) Turbuhaler(®) for both genders, however more effort for optimal inhalation technique is advised for persons with low vital capacity. This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations. The methodology developed in this study will be applicable also to other marketed drugs in the future.","internal_url":"https://www.academia.edu/73088230/Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug","translated_internal_url":"","created_at":"2022-03-05T01:51:08.193-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation"},{"id":172705,"name":"Dry Powder Inhalers","url":"https://www.academia.edu/Documents/in/Dry_Powder_Inhalers"},{"id":390245,"name":"Particle Size","url":"https://www.academia.edu/Documents/in/Particle_Size"},{"id":393958,"name":"Respiratory System","url":"https://www.academia.edu/Documents/in/Respiratory_System"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088229"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088229/A_sziszt%C3%A9m%C3%A1s_lupus_erythematosus_pulmonalis_manifeszt%C3%A1ci%C3%B3i"><img alt="Research paper thumbnail of A szisztémás lupus erythematosus pulmonalis manifesztációi" class="work-thumbnail" src="https://attachments.academia-assets.com/81747805/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088229/A_sziszt%C3%A9m%C3%A1s_lupus_erythematosus_pulmonalis_manifeszt%C3%A1ci%C3%B3i">A szisztémás lupus erythematosus pulmonalis manifesztációi</a></div><div class="wp-workCard_item"><span>Orvosi Hetilap</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Systemic lupus erythematosus is the most common connective tissue disease that is associated with...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Systemic lupus erythematosus is the most common connective tissue disease that is associated with pulmonary manifestations. Although lupus has the potential to affect any organ, lung involvement is observed during the course of the disease in most cases and it is prognostic for outcome. Pulmonary manifestations in lupus can be classified into five groups based on the anatomical involvement: pleura, lung parenchyma, bronchi and bronchioli, lung vasculature and respiratory muscles can be involved. The most common respiratory manifestations attributable to lupus are pleuritis with or without pleural effusion, pulmonary vascular disease, upper and lower airway dysfunction, parenchymal disease, and diaphragmatic dysfunction (shrinking lung syndrome). In this article the authors summarize lung involvement of lupus, its diagnosis, therapy and prognosis. Orv. Hetil., 2016, 157(29), 1154–1160.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="330f462589d24a94979ab0efa8984b0e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747805,"asset_id":73088229,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747805/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088229"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088229"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088229; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088229]").text(description); $(".js-view-count[data-work-id=73088229]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088229; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088229']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088229, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "330f462589d24a94979ab0efa8984b0e" } } $('.js-work-strip[data-work-id=73088229]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088229,"title":"A szisztémás lupus erythematosus pulmonalis manifesztációi","translated_title":"","metadata":{"abstract":"Systemic lupus erythematosus is the most common connective tissue disease that is associated with pulmonary manifestations. Although lupus has the potential to affect any organ, lung involvement is observed during the course of the disease in most cases and it is prognostic for outcome. Pulmonary manifestations in lupus can be classified into five groups based on the anatomical involvement: pleura, lung parenchyma, bronchi and bronchioli, lung vasculature and respiratory muscles can be involved. The most common respiratory manifestations attributable to lupus are pleuritis with or without pleural effusion, pulmonary vascular disease, upper and lower airway dysfunction, parenchymal disease, and diaphragmatic dysfunction (shrinking lung syndrome). In this article the authors summarize lung involvement of lupus, its diagnosis, therapy and prognosis. Orv. Hetil., 2016, 157(29), 1154–1160.","publisher":"Akademiai Kiado Zrt.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Orvosi Hetilap"},"translated_abstract":"Systemic lupus erythematosus is the most common connective tissue disease that is associated with pulmonary manifestations. Although lupus has the potential to affect any organ, lung involvement is observed during the course of the disease in most cases and it is prognostic for outcome. Pulmonary manifestations in lupus can be classified into five groups based on the anatomical involvement: pleura, lung parenchyma, bronchi and bronchioli, lung vasculature and respiratory muscles can be involved. The most common respiratory manifestations attributable to lupus are pleuritis with or without pleural effusion, pulmonary vascular disease, upper and lower airway dysfunction, parenchymal disease, and diaphragmatic dysfunction (shrinking lung syndrome). In this article the authors summarize lung involvement of lupus, its diagnosis, therapy and prognosis. Orv. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088227"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088227/Asthma_COPD_overlap_szindr%C3%B3ma"><img alt="Research paper thumbnail of Asthma-COPD overlap szindróma" class="work-thumbnail" src="https://attachments.academia-assets.com/81747806/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088227/Asthma_COPD_overlap_szindr%C3%B3ma">Asthma-COPD overlap szindróma</a></div><div class="wp-workCard_item"><span>Orvosi Hetilap</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Obstructive lung diseases represent a major health problem worldwide due to their high prevalence...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma – chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. The aim of this review is to summarize the currently available literature focusi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bdca33b2bebf430c73ba60c121322415" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747806,"asset_id":73088227,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747806/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088227"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088227"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088227; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088227]").text(description); $(".js-view-count[data-work-id=73088227]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088227; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088227']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088227, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bdca33b2bebf430c73ba60c121322415" } } $('.js-work-strip[data-work-id=73088227]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088227,"title":"Asthma-COPD overlap szindróma","translated_title":"","metadata":{"abstract":"Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088225"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088225/Circulating_periostin_level_in_asthmatic_pregnancy"><img alt="Research paper thumbnail of Circulating periostin level in asthmatic pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/81747807/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088225/Circulating_periostin_level_in_asthmatic_pregnancy">Circulating periostin level in asthmatic pregnancy</a></div><div class="wp-workCard_item"><span>The Journal of asthma : official journal of the Association for the Care of Asthma</span><span>, Jan 24, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Asthma often complicates pregnancy and represents a risk for complications. Periostin is consider...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Asthma often complicates pregnancy and represents a risk for complications. Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy. Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. Plasma periostin levels were similar in the HNP and ANP (55.68 [37.21-67.20] vs. 45.25 [32.67-64.55], p &gt; 0.05), and elevated in the HP (68.81 [57.34-98.84] ng/mL, p = 0.02 vs. HNP) and AP groups (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). Periostin levels of the two ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a6cc5826019e6fb08ad81e6986a426e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747807,"asset_id":73088225,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747807/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088225"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088225"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088225; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088225]").text(description); $(".js-view-count[data-work-id=73088225]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088225; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088225']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088225, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a6cc5826019e6fb08ad81e6986a426e" } } $('.js-work-strip[data-work-id=73088225]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088225,"title":"Circulating periostin level in asthmatic pregnancy","translated_title":"","metadata":{"abstract":"Asthma often complicates pregnancy and represents a risk for complications. 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Plasma periostin levels were similar in the HNP and ANP (55.68 [37.21-67.20] vs. 45.25 [32.67-64.55], p \u0026gt; 0.05), and elevated in the HP (68.81 [57.34-98.84] ng/mL, p = 0.02 vs. HNP) and AP groups (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). 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Elevated plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is related to a worse prognosis in many conditions such as infectious, autoimmune, or pregnancy-related diseases; however the value of suPAR in asthma and asthmatic pregnancy is unknown. The present study aimed to investigate the suPAR, CRP and IL-6 levels in asthma (asthmatic non-pregnant, ANP; N = 38; female N = 27) and asthmatic pregnancy (AP; N = 15), compared to healthy non-pregnant controls (HNP; N = 29; female N = 19) and to healthy pregnant women (HP; N = 58). The relationship between suPAR levels and asthma control was also evaluated. The diagnostic efficacy of suPAR in asthma control was analyzed using ROC analysis. IL-6 and CRP levels were comparable in all study groups. Circulating suPAR levels were lower in HP and AP than in HNP and ANP subjects, respectively (2.01 [1.81-2.38] and 2.39 [2.07-2.69] vs. 2.60 [1.82-3.49] and 2.84 [2.33-3.72] ng/mL, respectively, p = 0.0001). suPAR and airway resistance correlated in ANP (r = 0.47, p = 0.004). ROC analysis of suPAR values in ANP patients with PEF above and below 80% yielded an AUC of 0.75 (95% CI: 0.57-0.92, p = 0.023) and with ACT total score above and below 20 an AUC of 0.80 (95% CI: 0.64-0.95, p = 0.006). The cutoff value of suPAR to discriminate between controlled and not controlled AP and ANP was 4.04 ng/mL. In conclusion, suPAR may help the objective assessment of asthma control, since it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control. Decrease in circulating suPAR levels detected both in healthy and asthmatic pregnant women presumably represents pregnancy induced immune tolerance.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":93658301},"translated_abstract":null,"internal_url":"https://www.academia.edu/89963562/Relationship_of_Circulating_Soluble_Urokinase_Plasminogen_Activator_Receptor_suPAR_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_internal_url":"","created_at":"2022-11-04T07:28:20.574-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93658301,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93658301/thumbnails/1.jpg","file_name":"e4de18d4dc5e911980fe3bc06a614ff7f755.pdf","download_url":"https://www.academia.edu/attachments/93658301/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Soluble_Urok.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93658301/e4de18d4dc5e911980fe3bc06a614ff7f755-libre.pdf?1667591359=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Soluble_Urok.pdf\u0026Expires=1732749062\u0026Signature=NMt8sehz3CVDsGJanypUi2J8Ea9FKsGBpfrCjZp2rXv5A7mwjymj~rSEPQr5JTWEhQeKgU~YA9u7EBhiGmD9g3zBGkBVvoZ313kD~2LG3webjnQN8jkIg9bSla1RKcUbRZ6sandDE4KtglJNPWKPAzr~9~07AHPC6udaRLpwV~tskklYlaGB1wJ7bn-0DybznGUO0J8k6wvhJhA0U1bTPd3uZ-ND-A6fqLl3~kbtym7w6Z5K~HltbwThRhvpIFO7jEZexQgNtARDlUZ4s3dslLU4PX-AWkWfy4sY8OxcNHKY~b8PF3bZyu0CAOU8g7o7xXxkERHB3b9jm6-OK-XVfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Relationship_of_Circulating_Soluble_Urokinase_Plasminogen_Activator_Receptor_suPAR_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":93658301,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93658301/thumbnails/1.jpg","file_name":"e4de18d4dc5e911980fe3bc06a614ff7f755.pdf","download_url":"https://www.academia.edu/attachments/93658301/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Soluble_Urok.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93658301/e4de18d4dc5e911980fe3bc06a614ff7f755-libre.pdf?1667591359=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Soluble_Urok.pdf\u0026Expires=1732749062\u0026Signature=NMt8sehz3CVDsGJanypUi2J8Ea9FKsGBpfrCjZp2rXv5A7mwjymj~rSEPQr5JTWEhQeKgU~YA9u7EBhiGmD9g3zBGkBVvoZ313kD~2LG3webjnQN8jkIg9bSla1RKcUbRZ6sandDE4KtglJNPWKPAzr~9~07AHPC6udaRLpwV~tskklYlaGB1wJ7bn-0DybznGUO0J8k6wvhJhA0U1bTPd3uZ-ND-A6fqLl3~kbtym7w6Z5K~HltbwThRhvpIFO7jEZexQgNtARDlUZ4s3dslLU4PX-AWkWfy4sY8OxcNHKY~b8PF3bZyu0CAOU8g7o7xXxkERHB3b9jm6-OK-XVfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":47155,"name":"Birth Weight","url":"https://www.academia.edu/Documents/in/Birth_Weight"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":234864,"name":"Urokinase","url":"https://www.academia.edu/Documents/in/Urokinase"},{"id":295452,"name":"C reactive protein","url":"https://www.academia.edu/Documents/in/C_reactive_protein"},{"id":338534,"name":"Biomarker","url":"https://www.academia.edu/Documents/in/Biomarker"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"}],"urls":[{"id":25537743,"url":"http://dx.plos.org/10.1371/journal.pone.0060697"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="82548734"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/82548734/Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy"><img alt="Research paper thumbnail of Relationship of Circulating Hyaluronic Acid Levels to Disease Control in Asthma and Asthmatic Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/88225469/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/82548734/Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy">Relationship of Circulating Hyaluronic Acid Levels to Disease Control in Asthma and Asthmatic Pregnancy</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="20e71d96efe421b242651d2e36a83407" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":88225469,"asset_id":82548734,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/88225469/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="82548734"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="82548734"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 82548734; 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Hyaluronic acid (HA), a potential peripheral blood marker of tissue fibrosis in various diseases, promotes eosinophil survival and plays a role in asthmatic airway inflammation as well as in physiological processes necessary to maintain normal pregnancy; however the level of circulating HA in asthma and asthmatic pregnancy is unknown. We investigated HA levels in asthmatic patients (N = 52; asthmatic pregnant (AP) N = 16; asthmatic non-pregnant (ANP) N = 36) and tested their relationship to asthma control. Serum HA level was lower in AP than in ANP patients (27 [24.7-31.55] vs. 37.4 [30.1-66.55] ng/mL, p = 0.006); the difference attenuated to a trend after its adjustment for patients' age (p = 0.056). HA levels and airway resistance were positively (r = 0.467, p = 0.004), HA levels and Asthma Control Test (ACT) total score inversely (r = 20.437, p = 0.01) associated in ANP patients; these relationships remained significant even after their adjustments for age. The potential value of HA in the determination of asthma control was analyzed using ROC analysis which revealed that HA values discriminate patients with ACT total score $20 (controlled patients) and ,20 (uncontrolled patients) with a 0.826 efficacy (AUC, 95% CI: 0.69-0.97, p = 0.001) when 37.4 ng/mL is used as cutoff value in ANP group, and with 0.78 efficacy (AUC, 95% CI: 0.65-0.92, p = 0.0009) in the whole asthmatic cohort. In conclusion circulating HA might be a marker of asthma control, as it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control. Decrease of HA level in pregnancy may be the consequence of pregnancy induced immune tolerance.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":88225469},"translated_abstract":null,"internal_url":"https://www.academia.edu/82548734/Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_internal_url":"","created_at":"2022-07-04T10:34:29.944-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":88225469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/88225469/thumbnails/1.jpg","file_name":"9569805937af1f470c75f3a378540034f808.pdf","download_url":"https://www.academia.edu/attachments/88225469/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Hyaluronic_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/88225469/9569805937af1f470c75f3a378540034f808-libre.pdf?1656958308=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Hyaluronic_A.pdf\u0026Expires=1732749062\u0026Signature=QJhcKqLIb-V3g-Bz3eyqP6eILLwcPeExxeTN0mPGhSqtoqURPmyHMjpWFu7vUsYQdLFfNRYLYvuxwum-Ym18B2AmALtYq2fRr8~MSc0~mRGpfzN4hy-QvaTFKb6zWGpTfvBTHgNlgi6pJgvcstdIx2guNqE4CfB~RrSLR0gUZGSOwA4F4Fq6AxO1CiNIkXaR4DpSldK93Y1eU2RnEcX~XPzVbITe4KspfqF1f0f54fXKLIKQXRbqJxciii~xk-twBW0u1L8dkL52UbcKGIr1ik~AF042OR2ILEHzshNclXxsGcxgdx6o0N5bpm9N2Y0lX5h4ObdgDmnUVyi~lOrX~w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Relationship_of_Circulating_Hyaluronic_Acid_Levels_to_Disease_Control_in_Asthma_and_Asthmatic_Pregnancy","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":88225469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/88225469/thumbnails/1.jpg","file_name":"9569805937af1f470c75f3a378540034f808.pdf","download_url":"https://www.academia.edu/attachments/88225469/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Relationship_of_Circulating_Hyaluronic_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/88225469/9569805937af1f470c75f3a378540034f808-libre.pdf?1656958308=\u0026response-content-disposition=attachment%3B+filename%3DRelationship_of_Circulating_Hyaluronic_A.pdf\u0026Expires=1732749062\u0026Signature=QJhcKqLIb-V3g-Bz3eyqP6eILLwcPeExxeTN0mPGhSqtoqURPmyHMjpWFu7vUsYQdLFfNRYLYvuxwum-Ym18B2AmALtYq2fRr8~MSc0~mRGpfzN4hy-QvaTFKb6zWGpTfvBTHgNlgi6pJgvcstdIx2guNqE4CfB~RrSLR0gUZGSOwA4F4Fq6AxO1CiNIkXaR4DpSldK93Y1eU2RnEcX~XPzVbITe4KspfqF1f0f54fXKLIKQXRbqJxciii~xk-twBW0u1L8dkL52UbcKGIr1ik~AF042OR2ILEHzshNclXxsGcxgdx6o0N5bpm9N2Y0lX5h4ObdgDmnUVyi~lOrX~w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":300179,"name":"Hyaluronic Acid","url":"https://www.academia.edu/Documents/in/Hyaluronic_Acid"},{"id":3298155,"name":"Pregnancy complications","url":"https://www.academia.edu/Documents/in/Pregnancy_complications"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088241"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088241/Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis"><img alt="Research paper thumbnail of Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at the time of diagnosis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088241/Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis">Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at the time of diagnosis</a></div><div class="wp-workCard_item"><span>Lung cancer</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infecti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infections influence tumor genesis and anticancer therapy in several organs. As data on lower respiratory tract infection (LRTI) and lung cancer outcome are scarce our objective was to determine potential role of LRTI on one-year mortality and its effect on therapeutic possibilities in patients with pulmonary malignancies. All patients diagnosed in 2017 who had bronchoscopic microbial sampling at the time of lung cancer diagnosis (N=143) were included. Group 1 (LRTI+) included patients with confirmed LRTI (N=74) and Group 2 (LRTI-) with no infection (N=69). Clinical characteristics, pathogen profile and one-year survival was analyzed. Age, gender, TNM, stage, histology type, comorbidities or underlying lung disease did not differ among groups. Performance status 0 was significantly less common in Group 1 (LRTI+), while significantly increased neutrophil/lymphocyte ratio was observed. Most common LRTI pathogens included aerobic (N=49), anaerobic (N=14) and fungal (N=26) infections. Chemo/immune/target therapy alone or in combination with radiotherapy were significantly less common in Group 1 (LRTI+) and more patients were only eligible for palliative care. Group 1 patients with LRTI of multiple pathogens compared to single pathogen infection were significantly older, had less frequently adenocarcinoma and had worse performance status. One-year median survival for all patients was 274 days (235 vs. 305 days Group 1 vs Group 2). LRTI is associated with lower one-year median survival of pulmonary malignancy patients, especially in patients with multiple pathogen infections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088241"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088241"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088241; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088241]").text(description); $(".js-view-count[data-work-id=73088241]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088241; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088241']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088241, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088241]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088241,"title":"Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at the time of diagnosis","translated_title":"","metadata":{"abstract":"Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infections influence tumor genesis and anticancer therapy in several organs. As data on lower respiratory tract infection (LRTI) and lung cancer outcome are scarce our objective was to determine potential role of LRTI on one-year mortality and its effect on therapeutic possibilities in patients with pulmonary malignancies. All patients diagnosed in 2017 who had bronchoscopic microbial sampling at the time of lung cancer diagnosis (N=143) were included. Group 1 (LRTI+) included patients with confirmed LRTI (N=74) and Group 2 (LRTI-) with no infection (N=69). Clinical characteristics, pathogen profile and one-year survival was analyzed. Age, gender, TNM, stage, histology type, comorbidities or underlying lung disease did not differ among groups. Performance status 0 was significantly less common in Group 1 (LRTI+), while significantly increased neutrophil/lymphocyte ratio was observed. Most common LRTI pathogens included aerobic (N=49), anaerobic (N=14) and fungal (N=26) infections. Chemo/immune/target therapy alone or in combination with radiotherapy were significantly less common in Group 1 (LRTI+) and more patients were only eligible for palliative care. Group 1 patients with LRTI of multiple pathogens compared to single pathogen infection were significantly older, had less frequently adenocarcinoma and had worse performance status. One-year median survival for all patients was 274 days (235 vs. 305 days Group 1 vs Group 2). LRTI is associated with lower one-year median survival of pulmonary malignancy patients, especially in patients with multiple pathogen infections.","publisher":"European Respiratory Society","publication_name":"Lung cancer"},"translated_abstract":"Pulmonary malignancy is one of the most frequent and fatal cancers in older age patients. Infections influence tumor genesis and anticancer therapy in several organs. As data on lower respiratory tract infection (LRTI) and lung cancer outcome are scarce our objective was to determine potential role of LRTI on one-year mortality and its effect on therapeutic possibilities in patients with pulmonary malignancies. All patients diagnosed in 2017 who had bronchoscopic microbial sampling at the time of lung cancer diagnosis (N=143) were included. Group 1 (LRTI+) included patients with confirmed LRTI (N=74) and Group 2 (LRTI-) with no infection (N=69). Clinical characteristics, pathogen profile and one-year survival was analyzed. Age, gender, TNM, stage, histology type, comorbidities or underlying lung disease did not differ among groups. Performance status 0 was significantly less common in Group 1 (LRTI+), while significantly increased neutrophil/lymphocyte ratio was observed. Most common LRTI pathogens included aerobic (N=49), anaerobic (N=14) and fungal (N=26) infections. Chemo/immune/target therapy alone or in combination with radiotherapy were significantly less common in Group 1 (LRTI+) and more patients were only eligible for palliative care. Group 1 patients with LRTI of multiple pathogens compared to single pathogen infection were significantly older, had less frequently adenocarcinoma and had worse performance status. One-year median survival for all patients was 274 days (235 vs. 305 days Group 1 vs Group 2). LRTI is associated with lower one-year median survival of pulmonary malignancy patients, especially in patients with multiple pathogen infections.","internal_url":"https://www.academia.edu/73088241/Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis","translated_internal_url":"","created_at":"2022-03-05T01:51:10.782-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Worse_lung_cancer_outcome_in_patients_with_lower_respiratory_tract_infection_confirmed_at_the_time_of_diagnosis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51698,"name":"Lung Cancer","url":"https://www.academia.edu/Documents/in/Lung_Cancer"}],"urls":[{"id":18260899,"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2019.PA4666"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088240"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088240/Central_European_idiopathic_pulmonary_fibrosis_IPF_patients_survey"><img alt="Research paper thumbnail of Central European idiopathic pulmonary fibrosis (IPF) patients survey" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088240/Central_European_idiopathic_pulmonary_fibrosis_IPF_patients_survey">Central European idiopathic pulmonary fibrosis (IPF) patients survey</a></div><div class="wp-workCard_item"><span>Idiopathic interstitial pneumonias</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088240"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088240"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088240; 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Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results: The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.","publication_name":"Respiratory Research","grobid_abstract_attachment_id":81747766},"translated_abstract":null,"internal_url":"https://www.academia.edu/73088239/Genetic_influences_on_the_onset_of_obstructive_sleep_apnoea_and_daytime_sleepiness_a_twin_study","translated_internal_url":"","created_at":"2022-03-05T01:51:10.390-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81747766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747766/thumbnails/1.jpg","file_name":"s12931-019-1095-x.pdf","download_url":"https://www.academia.edu/attachments/81747766/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_influences_on_the_onset_of_obstr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747766/s12931-019-1095-x-libre.pdf?1646475987=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_influences_on_the_onset_of_obstr.pdf\u0026Expires=1732749062\u0026Signature=NZA8ZTUSLdOBmdJ5ehZMmJuIkH949gLiqAT36PJwFUlAXhsjN2X09iLpKMGASU6AmkxhG2goiRSbufUycwr-dO1pMIS9EtvfDr0c27PZqqJAQFCg5yoh9n7D9UqCzjHBELAszCGK-2PB3Oo7jY27ifKCxzyEgOMbN5ibB-MmWLbsEI6gnCn-OYz9F4vNuKWMR3r1s8s3RW5YfZSb1KciJdHtWKsm-bzcOVrbVyOvO46MedgLKxZnIBm-v9TAx0rNCTQezMPPSzYh73sMKEqEIjxE1lEyl3vmB0moimKiEiae2kbINb8Xji9mTGui1zhLQPXy0lz8eXW357leNEStuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Genetic_influences_on_the_onset_of_obstructive_sleep_apnoea_and_daytime_sleepiness_a_twin_study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":81747766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747766/thumbnails/1.jpg","file_name":"s12931-019-1095-x.pdf","download_url":"https://www.academia.edu/attachments/81747766/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_influences_on_the_onset_of_obstr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747766/s12931-019-1095-x-libre.pdf?1646475987=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_influences_on_the_onset_of_obstr.pdf\u0026Expires=1732749062\u0026Signature=NZA8ZTUSLdOBmdJ5ehZMmJuIkH949gLiqAT36PJwFUlAXhsjN2X09iLpKMGASU6AmkxhG2goiRSbufUycwr-dO1pMIS9EtvfDr0c27PZqqJAQFCg5yoh9n7D9UqCzjHBELAszCGK-2PB3Oo7jY27ifKCxzyEgOMbN5ibB-MmWLbsEI6gnCn-OYz9F4vNuKWMR3r1s8s3RW5YfZSb1KciJdHtWKsm-bzcOVrbVyOvO46MedgLKxZnIBm-v9TAx0rNCTQezMPPSzYh73sMKEqEIjxE1lEyl3vmB0moimKiEiae2kbINb8Xji9mTGui1zhLQPXy0lz8eXW357leNEStuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81747767,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747767/thumbnails/1.jpg","file_name":"s12931-019-1095-x.pdf","download_url":"https://www.academia.edu/attachments/81747767/download_file","bulk_download_file_name":"Genetic_influences_on_the_onset_of_obstr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747767/s12931-019-1095-x-libre.pdf?1646475986=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_influences_on_the_onset_of_obstr.pdf\u0026Expires=1732749062\u0026Signature=cqi6LuoVKgyVW7PX8mvKr7ZR0BlDVfAudl18xscQNAn4XIBmIQNzCD4V43yBTTQ1df8OHcgIu17JPHC0q4VpiHCyzwyW6ZjmRYaQ~g~tEs6wCY8w0Uuci1Z0oj0hIXHFA1K7NPdk6IHK89r9Jm1fLrH0-mBRjnIJCyAqIHJJ3WLj4uG2~ee0sYYP7f0YSMWIxuKPvUvaEw3-mgh-RqNHkb6yq-slhtpgJQRcCvGq8ifS2FO-2yIxL7jEE6pFwn1qNbiGuFTj3JZ3MQpPPjuVY98~Uu1P4ukGmqnaZ-0oTcdBcx8bO3ZMCcUY72IrokRR7X62kp1E5CggFC9bS-IWEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":400071,"name":"Respiratory","url":"https://www.academia.edu/Documents/in/Respiratory"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":18260897,"url":"http://link.springer.com/content/pdf/10.1186/s12931-019-1095-x.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088238"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088238/Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma"><img alt="Research paper thumbnail of Relationship between HRCT changes and clinical parameters in patients with scleroderma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088238/Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma">Relationship between HRCT changes and clinical parameters in patients with scleroderma</a></div><div class="wp-workCard_item"><span>Imaging</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degenerat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degeneration of the connective tissue in the lung, which is one of the most frequently involved organ related to this process. The extent of the lung involvement can be assessed in the high resolution CT (HRCT), which has important relevance in the prognosis and therapy. The aim of this study was to assess the relationship between visible changes in the HRCT and clinical parameters such as lung function and serology. Methods: 34 SS patients with abnormal lung functions or X-ray images were selected to undergo an HRCT between January 2014 and September 2017. All HRCT image has been scored for the intensity of ground glass opacity (GGO), lung fibrosis, bronchiectasis and honeycombing. Additional parameters like vascular diameters and lung volume have been calculated. These radiological parameters have been compared to clinical parameters of the lung function (FVC, FEV1, TLCO, KLCO) and the serology (anti-nuclear antibody, ANA). Results: A significant association between morphological changes in the HRCT and lung volume was found (3919± 989 liters, p=0.011), as well as an association between the total lung volume and fibrosis (p=0.090). ANA showed a very strong correlation with GGOs (p=0.009) and a borderline correlation with the HRCT score (p=0.059). Conclusion: HRCT was a very useful method for the diagnosis of interstitial lung fibrosis in scleroderma patients. The lung volume was associated with the extension of interstitial lung disease and fibrosis. The extension of alveolitis showed association with ANA and HRCT score, therefore, it might be useful in the quantification of the disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088238"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088238"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088238; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088238]").text(description); $(".js-view-count[data-work-id=73088238]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088238; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088238']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088238, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088238]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088238,"title":"Relationship between HRCT changes and clinical parameters in patients with scleroderma","translated_title":"","metadata":{"abstract":"Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degeneration of the connective tissue in the lung, which is one of the most frequently involved organ related to this process. The extent of the lung involvement can be assessed in the high resolution CT (HRCT), which has important relevance in the prognosis and therapy. The aim of this study was to assess the relationship between visible changes in the HRCT and clinical parameters such as lung function and serology. Methods: 34 SS patients with abnormal lung functions or X-ray images were selected to undergo an HRCT between January 2014 and September 2017. All HRCT image has been scored for the intensity of ground glass opacity (GGO), lung fibrosis, bronchiectasis and honeycombing. Additional parameters like vascular diameters and lung volume have been calculated. These radiological parameters have been compared to clinical parameters of the lung function (FVC, FEV1, TLCO, KLCO) and the serology (anti-nuclear antibody, ANA). Results: A significant association between morphological changes in the HRCT and lung volume was found (3919± 989 liters, p=0.011), as well as an association between the total lung volume and fibrosis (p=0.090). ANA showed a very strong correlation with GGOs (p=0.009) and a borderline correlation with the HRCT score (p=0.059). Conclusion: HRCT was a very useful method for the diagnosis of interstitial lung fibrosis in scleroderma patients. The lung volume was associated with the extension of interstitial lung disease and fibrosis. The extension of alveolitis showed association with ANA and HRCT score, therefore, it might be useful in the quantification of the disease.","publisher":"European Respiratory Society","publication_name":"Imaging"},"translated_abstract":"Introduction: Systemic sclerosis (SS), the most severe form of scleroderma, can lead to degeneration of the connective tissue in the lung, which is one of the most frequently involved organ related to this process. The extent of the lung involvement can be assessed in the high resolution CT (HRCT), which has important relevance in the prognosis and therapy. The aim of this study was to assess the relationship between visible changes in the HRCT and clinical parameters such as lung function and serology. Methods: 34 SS patients with abnormal lung functions or X-ray images were selected to undergo an HRCT between January 2014 and September 2017. All HRCT image has been scored for the intensity of ground glass opacity (GGO), lung fibrosis, bronchiectasis and honeycombing. Additional parameters like vascular diameters and lung volume have been calculated. These radiological parameters have been compared to clinical parameters of the lung function (FVC, FEV1, TLCO, KLCO) and the serology (anti-nuclear antibody, ANA). Results: A significant association between morphological changes in the HRCT and lung volume was found (3919± 989 liters, p=0.011), as well as an association between the total lung volume and fibrosis (p=0.090). ANA showed a very strong correlation with GGOs (p=0.009) and a borderline correlation with the HRCT score (p=0.059). Conclusion: HRCT was a very useful method for the diagnosis of interstitial lung fibrosis in scleroderma patients. The lung volume was associated with the extension of interstitial lung disease and fibrosis. The extension of alveolitis showed association with ANA and HRCT score, therefore, it might be useful in the quantification of the disease.","internal_url":"https://www.academia.edu/73088238/Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma","translated_internal_url":"","created_at":"2022-03-05T01:51:10.216-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Relationship_between_HRCT_changes_and_clinical_parameters_in_patients_with_scleroderma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":6201,"name":"Imaging","url":"https://www.academia.edu/Documents/in/Imaging"}],"urls":[{"id":18260896,"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2018.PA859"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088237"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088237/Arterial_stiffness_measurement_on_lung_transplanted_patients"><img alt="Research paper thumbnail of Arterial stiffness measurement on lung transplanted patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088237/Arterial_stiffness_measurement_on_lung_transplanted_patients">Arterial stiffness measurement on lung transplanted patients</a></div><div class="wp-workCard_item"><span>Transplantation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088237"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088237"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088237; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088236"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088236/The_European_IPF_registry_eurIPFreg_baseline_characteristics_and_survival_of_patients_with_idiopathic_pulmonary_fibrosis"><img alt="Research paper thumbnail of The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/81747812/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088236/The_European_IPF_registry_eurIPFreg_baseline_characteristics_and_survival_of_patients_with_idiopathic_pulmonary_fibrosis">The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis</a></div><div class="wp-workCard_item"><span>Respiratory research</span><span>, Jul 28, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiologica...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The registry data are based on patient and physician baseline and follow-up questionnaires, comprising 1700 parameters. The mid- to long-term objectives of the registry are to provide clues for a better understanding of IPF phenotype sub-clusters, triggering factors and aggravating conditions, regional and environmental characteristics, and of disease behavior and management. This paper describes baseline data of 525 IPF subjects recruited from 11/2009 until 10/2016. IPF patients had a mean age of 68.1 years, and seeked medical advice due to insidious dyspnea (90.1%), fatigue (69.2%), and dry coughing (53.2%). A surgical lung biopsy was performed in 32% in 2009, but in only 8% of the cases in 2016, possibly due to increased numbers of cryobiopsy. At the time of inclusion in the eurIPFreg, FVC was 68.4% ± 22.6% of predicted value, DLco r...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4b57a327b1af37f8628075a608798c48" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747812,"asset_id":73088236,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747812/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088236"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088236"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088236; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088236]").text(description); $(".js-view-count[data-work-id=73088236]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088236; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088236']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088236, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4b57a327b1af37f8628075a608798c48" } } $('.js-work-strip[data-work-id=73088236]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088236,"title":"The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis","translated_title":"","metadata":{"abstract":"Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The registry data are based on patient and physician baseline and follow-up questionnaires, comprising 1700 parameters. The mid- to long-term objectives of the registry are to provide clues for a better understanding of IPF phenotype sub-clusters, triggering factors and aggravating conditions, regional and environmental characteristics, and of disease behavior and management. This paper describes baseline data of 525 IPF subjects recruited from 11/2009 until 10/2016. IPF patients had a mean age of 68.1 years, and seeked medical advice due to insidious dyspnea (90.1%), fatigue (69.2%), and dry coughing (53.2%). A surgical lung biopsy was performed in 32% in 2009, but in only 8% of the cases in 2016, possibly due to increased numbers of cryobiopsy. At the time of inclusion in the eurIPFreg, FVC was 68.4% ± 22.6% of predicted value, DLco r...","publication_date":{"day":28,"month":7,"year":2018,"errors":{}},"publication_name":"Respiratory research"},"translated_abstract":"Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The registry data are based on patient and physician baseline and follow-up questionnaires, comprising 1700 parameters. The mid- to long-term objectives of the registry are to provide clues for a better understanding of IPF phenotype sub-clusters, triggering factors and aggravating conditions, regional and environmental characteristics, and of disease behavior and management. This paper describes baseline data of 525 IPF subjects recruited from 11/2009 until 10/2016. IPF patients had a mean age of 68.1 years, and seeked medical advice due to insidious dyspnea (90.1%), fatigue (69.2%), and dry coughing (53.2%). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088235"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088235/Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy"><img alt="Research paper thumbnail of Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/81747811/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088235/Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy">Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy</a></div><div class="wp-workCard_item"><span>Canadian respiratory journal</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL,= 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml,= 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (= 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] g/mL,= 0.8730) and the level was lower in HP (98.80 [84.26-105.5] g/mL,= 0.0344 versus HNP). In contrast, the level was higher in AP ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3f4b7d66e18c277bbb3001ea7065c7ef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747811,"asset_id":73088235,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747811/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088235"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088235"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088235; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088235]").text(description); $(".js-view-count[data-work-id=73088235]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088235; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088235']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088235, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3f4b7d66e18c277bbb3001ea7065c7ef" } } $('.js-work-strip[data-work-id=73088235]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088235,"title":"Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy","translated_title":"","metadata":{"abstract":"Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL,= 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml,= 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (= 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] g/mL,= 0.8730) and the level was lower in HP (98.80 [84.26-105.5] g/mL,= 0.0344 versus HNP). In contrast, the level was higher in AP ...","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Canadian respiratory journal"},"translated_abstract":"Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL,= 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml,= 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (= 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] g/mL,= 0.8730) and the level was lower in HP (98.80 [84.26-105.5] g/mL,= 0.0344 versus HNP). In contrast, the level was higher in AP ...","internal_url":"https://www.academia.edu/73088235/Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy","translated_internal_url":"","created_at":"2022-03-05T01:51:09.741-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81747811,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747811/thumbnails/1.jpg","file_name":"1602039.pdf","download_url":"https://www.academia.edu/attachments/81747811/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Circulating_Clusterin_and_Osteopontin_Le.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747811/1602039-libre.pdf?1646475985=\u0026response-content-disposition=attachment%3B+filename%3DCirculating_Clusterin_and_Osteopontin_Le.pdf\u0026Expires=1732749062\u0026Signature=cnJ4~xCVxHjTOWTGje-zJDy0jZ4TYKUYP5Kfg9PGWYojOQEQ7hcGfrh9Xs39UeI19rnIKPKLxnufp1eS8LzeIfaDTDUD7cmuFLFs1aNaWdOTHt-s1S~m3vIafDLXz4XMo8~nflFVmWA-XoYl~jIOMZyc8tKZnVD1lYgs~H5EyQ-GzysGK-iitiOnOPeGlWa~YMLwvLpUS0YhuZWRlcBENIgLrZWU8UFgfxMDXbUUeS94DyPrr-9VEuR4VAkOU9BjCRhUgP18Tio2-8lUSDC7BO~a8nDrYw3nQ2iyPXraSJnW6SlOqvgJWMSv84rh~g0Vorv1ZI2YMTOMQjuAM9FMUA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Circulating_Clusterin_and_Osteopontin_Levels_in_Asthma_and_Asthmatic_Pregnancy","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":81747811,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747811/thumbnails/1.jpg","file_name":"1602039.pdf","download_url":"https://www.academia.edu/attachments/81747811/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Circulating_Clusterin_and_Osteopontin_Le.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747811/1602039-libre.pdf?1646475985=\u0026response-content-disposition=attachment%3B+filename%3DCirculating_Clusterin_and_Osteopontin_Le.pdf\u0026Expires=1732749062\u0026Signature=cnJ4~xCVxHjTOWTGje-zJDy0jZ4TYKUYP5Kfg9PGWYojOQEQ7hcGfrh9Xs39UeI19rnIKPKLxnufp1eS8LzeIfaDTDUD7cmuFLFs1aNaWdOTHt-s1S~m3vIafDLXz4XMo8~nflFVmWA-XoYl~jIOMZyc8tKZnVD1lYgs~H5EyQ-GzysGK-iitiOnOPeGlWa~YMLwvLpUS0YhuZWRlcBENIgLrZWU8UFgfxMDXbUUeS94DyPrr-9VEuR4VAkOU9BjCRhUgP18Tio2-8lUSDC7BO~a8nDrYw3nQ2iyPXraSJnW6SlOqvgJWMSv84rh~g0Vorv1ZI2YMTOMQjuAM9FMUA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088234"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088234/Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience"><img alt="Research paper thumbnail of Seasonal changes of lower respiratory tract infections in lung transplant recipients during the first post-transplant year: The Hungarian experience" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088234/Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience">Seasonal changes of lower respiratory tract infections in lung transplant recipients during the first post-transplant year: The Hungarian experience</a></div><div class="wp-workCard_item"><span>Transplant Infectious Disease</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejectio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejection of the graft. Together with earlier colonization by pathogens, immunosuppression makes recipients more susceptible to infections, especially during the first postoperative year. As seasonality of lower respiratory tract infections (LRTI) is well-known in chronic lung diseases, we assessed seasonal changes of pathogen spectrum and number of infections in the first postoperative year in LuTX recipients. LRTI were analyzed in 28 Hungarian adult LuTX patients. Incidence and spectrum of microorganism causing LRTI were evaluated according to post-transplant time and seasonal temperature and humidity changes. A total of 69 cases of LRTI were registered (average: 1.9 cases/patient; range: 0-14). Gram-negative=59, gram-positive=26, and fungal=31 pathogens were detected, with polymicrobial samples in 46% of all cases. Increased number of LRTI was observed in the cold season (1.68±1.54 vs 0.79±0.92 case/month/patient, P&amp;lt;.01) and significant negative correlations were identified between the incidence of polymicrobial and bacterial infections and temperature (r =0.1535, P&amp;lt;.05, r =0.3144, P&amp;lt;.01, respectively). In addition, positive correlation was observed between polymicrobial infections and humidity (r =0.1403, P&amp;lt;.05). Higher incidence of LRTI was also noted in the cold season, when accounting for the differences in immunosuppression. Seasons influenced the incidence of LRTI in the first postoperative year in LuTX recipients. More intensive vigilance for possible gram-negative and polymicrobial infections is needed in these patients in cold and wet seasons in the continental climate zone, regardless of underlying disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088234"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088234"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088234; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088234]").text(description); $(".js-view-count[data-work-id=73088234]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088234; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088234']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088234, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088234]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088234,"title":"Seasonal changes of lower respiratory tract infections in lung transplant recipients during the first post-transplant year: The Hungarian experience","translated_title":"","metadata":{"abstract":"After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejection of the graft. Together with earlier colonization by pathogens, immunosuppression makes recipients more susceptible to infections, especially during the first postoperative year. As seasonality of lower respiratory tract infections (LRTI) is well-known in chronic lung diseases, we assessed seasonal changes of pathogen spectrum and number of infections in the first postoperative year in LuTX recipients. LRTI were analyzed in 28 Hungarian adult LuTX patients. Incidence and spectrum of microorganism causing LRTI were evaluated according to post-transplant time and seasonal temperature and humidity changes. A total of 69 cases of LRTI were registered (average: 1.9 cases/patient; range: 0-14). Gram-negative=59, gram-positive=26, and fungal=31 pathogens were detected, with polymicrobial samples in 46% of all cases. Increased number of LRTI was observed in the cold season (1.68±1.54 vs 0.79±0.92 case/month/patient, P\u0026amp;lt;.01) and significant negative correlations were identified between the incidence of polymicrobial and bacterial infections and temperature (r =0.1535, P\u0026amp;lt;.05, r =0.3144, P\u0026amp;lt;.01, respectively). In addition, positive correlation was observed between polymicrobial infections and humidity (r =0.1403, P\u0026amp;lt;.05). Higher incidence of LRTI was also noted in the cold season, when accounting for the differences in immunosuppression. Seasons influenced the incidence of LRTI in the first postoperative year in LuTX recipients. More intensive vigilance for possible gram-negative and polymicrobial infections is needed in these patients in cold and wet seasons in the continental climate zone, regardless of underlying disease.","publisher":"Wiley-Blackwell","publication_name":"Transplant Infectious Disease"},"translated_abstract":"After lung transplantation (LuTX) a high level of immunosuppression is needed to prevent rejection of the graft. Together with earlier colonization by pathogens, immunosuppression makes recipients more susceptible to infections, especially during the first postoperative year. As seasonality of lower respiratory tract infections (LRTI) is well-known in chronic lung diseases, we assessed seasonal changes of pathogen spectrum and number of infections in the first postoperative year in LuTX recipients. LRTI were analyzed in 28 Hungarian adult LuTX patients. Incidence and spectrum of microorganism causing LRTI were evaluated according to post-transplant time and seasonal temperature and humidity changes. A total of 69 cases of LRTI were registered (average: 1.9 cases/patient; range: 0-14). Gram-negative=59, gram-positive=26, and fungal=31 pathogens were detected, with polymicrobial samples in 46% of all cases. Increased number of LRTI was observed in the cold season (1.68±1.54 vs 0.79±0.92 case/month/patient, P\u0026amp;lt;.01) and significant negative correlations were identified between the incidence of polymicrobial and bacterial infections and temperature (r =0.1535, P\u0026amp;lt;.05, r =0.3144, P\u0026amp;lt;.01, respectively). In addition, positive correlation was observed between polymicrobial infections and humidity (r =0.1403, P\u0026amp;lt;.05). Higher incidence of LRTI was also noted in the cold season, when accounting for the differences in immunosuppression. Seasons influenced the incidence of LRTI in the first postoperative year in LuTX recipients. More intensive vigilance for possible gram-negative and polymicrobial infections is needed in these patients in cold and wet seasons in the continental climate zone, regardless of underlying disease.","internal_url":"https://www.academia.edu/73088234/Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience","translated_internal_url":"","created_at":"2022-03-05T01:51:09.497-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Seasonal_changes_of_lower_respiratory_tract_infections_in_lung_transplant_recipients_during_the_first_post_transplant_year_The_Hungarian_experience","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":81896,"name":"Hungary","url":"https://www.academia.edu/Documents/in/Hungary"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression"},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":444369,"name":"Humidity","url":"https://www.academia.edu/Documents/in/Humidity"},{"id":509782,"name":"Respiratory Tract Infections","url":"https://www.academia.edu/Documents/in/Respiratory_Tract_Infections"},{"id":587528,"name":"Bacterial infections","url":"https://www.academia.edu/Documents/in/Bacterial_infections"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":649451,"name":"Seasons","url":"https://www.academia.edu/Documents/in/Seasons"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1953423,"name":"Postoperative Period","url":"https://www.academia.edu/Documents/in/Postoperative_Period"},{"id":2731176,"name":"Lung Transplantation","url":"https://www.academia.edu/Documents/in/Lung_Transplantation"}],"urls":[{"id":18260894,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftid.12671"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088233"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088233/FP207GENDER_Dependent_Protective_Effect_of_Dhea_on_the_Hif_HSF_HSP_Axis_After_Renal_Ischemia_Reperfusion_Injury"><img alt="Research paper thumbnail of FP207GENDER Dependent Protective Effect of Dhea on the Hif-HSF-HSP Axis After Renal Ischemia/Reperfusion Injury" class="work-thumbnail" src="https://attachments.academia-assets.com/81747810/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088233/FP207GENDER_Dependent_Protective_Effect_of_Dhea_on_the_Hif_HSF_HSP_Axis_After_Renal_Ischemia_Reperfusion_Injury">FP207GENDER Dependent Protective Effect of Dhea on the Hif-HSF-HSP Axis After Renal Ischemia/Reperfusion Injury</a></div><div class="wp-workCard_item"><span>Nephrology Dialysis Transplantation</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="70f4f4156be57e17d813b804ab417cd3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747810,"asset_id":73088233,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747810/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088233"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088233"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088233; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088232"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088232/Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients"><img alt="Research paper thumbnail of Bronchoalveolar lavage fluid leukotrienes in the pathomechanism of acute inflammatory events in lung transplant recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088232/Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients">Bronchoalveolar lavage fluid leukotrienes in the pathomechanism of acute inflammatory events in lung transplant recipients</a></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during the follow up of lung transplanted (LTx) patients is not fully understood. Leukotrienes, products of lipoxygenase enzyme may play a potential role, however they have not been investigated before. Aims: To analyse bronchoalveolar lavage fluid (BALF) leukotrienes in lung transplant recipients. Methods: Thirty-three BALF samples were analysed in 13 LTx patients for leukotriene B4 (LTB4) and cysteinyl-leukotriene (Cys-LT) concentration. In 10 cases patients were considered stable (stable group), in 7 cases bronchial biopsy revealed acute rejection (rejection group), and in 15 cases no sign of acute rejection, but a significant (&gt;10 3 CFU/ml) bacterial or fungal colony count was observed (infection group). Leukotrienes were determined with ELISA. Results: There was no difference in BALF total leukocyte number, lymphocyte, neutrophil or eosinophil cell count between the three groups, however a &gt;5% neutrophil count was indicative for infection. A tendency for higher BALF LTB4 was observed in acute rejection (341±445 pg/ml, p=0.05) as well as infection (156±163 pg/ml, p=0.09) compared to stable samples (66±57 pg/ml), without any difference between acute rejection and infection (p=0.52). BALF LTB4 levels were not related to lung function or BALF cell counts. No difference was shown for Cys-LT (p&gt;0.05). Conclusion: Our results indicate that LTB4 may play a role in the pathomechanism of acute inflammatory events in lung transplanted patients. This needs to be investigated in an extended cohort of patients in detail. The study was supported by Hungarian Respiratory Society grant.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088232"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088232"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088232; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088232]").text(description); $(".js-view-count[data-work-id=73088232]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088232; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088232']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088232, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088232]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088232,"title":"Bronchoalveolar lavage fluid leukotrienes in the pathomechanism of acute inflammatory events in lung transplant recipients","translated_title":"","metadata":{"abstract":"Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during the follow up of lung transplanted (LTx) patients is not fully understood. Leukotrienes, products of lipoxygenase enzyme may play a potential role, however they have not been investigated before. Aims: To analyse bronchoalveolar lavage fluid (BALF) leukotrienes in lung transplant recipients. Methods: Thirty-three BALF samples were analysed in 13 LTx patients for leukotriene B4 (LTB4) and cysteinyl-leukotriene (Cys-LT) concentration. In 10 cases patients were considered stable (stable group), in 7 cases bronchial biopsy revealed acute rejection (rejection group), and in 15 cases no sign of acute rejection, but a significant (\u0026gt;10 3 CFU/ml) bacterial or fungal colony count was observed (infection group). Leukotrienes were determined with ELISA. Results: There was no difference in BALF total leukocyte number, lymphocyte, neutrophil or eosinophil cell count between the three groups, however a \u0026gt;5% neutrophil count was indicative for infection. A tendency for higher BALF LTB4 was observed in acute rejection (341±445 pg/ml, p=0.05) as well as infection (156±163 pg/ml, p=0.09) compared to stable samples (66±57 pg/ml), without any difference between acute rejection and infection (p=0.52). BALF LTB4 levels were not related to lung function or BALF cell counts. No difference was shown for Cys-LT (p\u0026gt;0.05). Conclusion: Our results indicate that LTB4 may play a role in the pathomechanism of acute inflammatory events in lung transplanted patients. This needs to be investigated in an extended cohort of patients in detail. The study was supported by Hungarian Respiratory Society grant.","publisher":"European Respiratory Society","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"European Respiratory Journal"},"translated_abstract":"Background: The pathomechanism of acute inflammatory events, i.e. infection and rejection during the follow up of lung transplanted (LTx) patients is not fully understood. Leukotrienes, products of lipoxygenase enzyme may play a potential role, however they have not been investigated before. Aims: To analyse bronchoalveolar lavage fluid (BALF) leukotrienes in lung transplant recipients. Methods: Thirty-three BALF samples were analysed in 13 LTx patients for leukotriene B4 (LTB4) and cysteinyl-leukotriene (Cys-LT) concentration. In 10 cases patients were considered stable (stable group), in 7 cases bronchial biopsy revealed acute rejection (rejection group), and in 15 cases no sign of acute rejection, but a significant (\u0026gt;10 3 CFU/ml) bacterial or fungal colony count was observed (infection group). Leukotrienes were determined with ELISA. Results: There was no difference in BALF total leukocyte number, lymphocyte, neutrophil or eosinophil cell count between the three groups, however a \u0026gt;5% neutrophil count was indicative for infection. A tendency for higher BALF LTB4 was observed in acute rejection (341±445 pg/ml, p=0.05) as well as infection (156±163 pg/ml, p=0.09) compared to stable samples (66±57 pg/ml), without any difference between acute rejection and infection (p=0.52). BALF LTB4 levels were not related to lung function or BALF cell counts. No difference was shown for Cys-LT (p\u0026gt;0.05). Conclusion: Our results indicate that LTB4 may play a role in the pathomechanism of acute inflammatory events in lung transplanted patients. This needs to be investigated in an extended cohort of patients in detail. The study was supported by Hungarian Respiratory Society grant.","internal_url":"https://www.academia.edu/73088232/Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients","translated_internal_url":"","created_at":"2022-03-05T01:51:09.156-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Bronchoalveolar_lavage_fluid_leukotrienes_in_the_pathomechanism_of_acute_inflammatory_events_in_lung_transplant_recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088231"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088231/Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry"><img alt="Research paper thumbnail of Does early diagnosis of idiopathic pulmonary fibrosis matter? Real- world´s data from the EMPIRE registry" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088231/Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry">Does early diagnosis of idiopathic pulmonary fibrosis matter? Real- world´s data from the EMPIRE registry</a></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 year...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 years. Delay in diagnosis and treatment probably decreases a survival in IPF. Our study aims to investigate influence of time from the first symptoms to diagnosis on the survival. CONCLUSIONS: Our results show that earlier diagnosis and treatment may increase survival in IPF. Early diagnosis and treatment does matter in prognosis of IPF patients and thus maximal effort should be generated to get the patients diagnosed and treated as early as possible.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088231"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088231"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088231; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088231]").text(description); $(".js-view-count[data-work-id=73088231]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088231; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088231']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088231, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088231]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088231,"title":"Does early diagnosis of idiopathic pulmonary fibrosis matter? Real- world´s data from the EMPIRE registry","translated_title":"","metadata":{"abstract":"AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 years. Delay in diagnosis and treatment probably decreases a survival in IPF. Our study aims to investigate influence of time from the first symptoms to diagnosis on the survival. CONCLUSIONS: Our results show that earlier diagnosis and treatment may increase survival in IPF. Early diagnosis and treatment does matter in prognosis of IPF patients and thus maximal effort should be generated to get the patients diagnosed and treated as early as possible.","publisher":"European Respiratory Society","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"European Respiratory Journal"},"translated_abstract":"AIMS: Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with mean survival of 2.5 years. Delay in diagnosis and treatment probably decreases a survival in IPF. Our study aims to investigate influence of time from the first symptoms to diagnosis on the survival. CONCLUSIONS: Our results show that earlier diagnosis and treatment may increase survival in IPF. Early diagnosis and treatment does matter in prognosis of IPF patients and thus maximal effort should be generated to get the patients diagnosed and treated as early as possible.","internal_url":"https://www.academia.edu/73088231/Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry","translated_internal_url":"","created_at":"2022-03-05T01:51:09.016-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Does_early_diagnosis_of_idiopathic_pulmonary_fibrosis_matter_Real_world_s_data_from_the_EMPIRE_registry","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088230"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088230/Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug"><img alt="Research paper thumbnail of Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088230/Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug">Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug</a></div><div class="wp-workCard_item"><span>European Journal of Pharmaceutical Sciences</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive pulmonary disease (COPD) management is Symbicort(®) Turbuhaler(®). The aim of this study was to simulate the deposition distribution of both components of this drug within the airways based on realistic airflow measurements. Breathing parameters of 25 healthy adults (11 females and 14 males) were acquired while inhaling through Turbuhaler(®). Individual specific emitted doses and particle size distributions of Symbicort(®) Turbuhaler(®) were determined. A self-developed particle deposition model was adapted and validated to simulate the deposition of budesonide (inhaled corticosteroid; ICS) and formoterol (long acting β2 agonist; LABA) in the upper airways and lungs of the healthy volunteers. Based on current simulations the emitted doses varied between 50.4% and 92.5% of the metered dose for the ICS, and between 38% and 96.1% in case of LABA component depending on the individual inhalation flow rate. This variability induced a notable inter-individual spread of the deposited lung doses (mean: 33.6%, range: 20.4%-48.8% for budesonide and mean: 29.8%, range: 16.4%-42.9% for formoterol). Significant inter-gender differences were also observed. Average lung dose of budesonide was 29.2% of the metered dose for females and 37% for males, while formoterol deposited with 26.4% efficiency for females and 32.5% for males. Present results also highlighted the importance of breath-holding after inhalation of the drug. About a half of the total lung deposition occurred during breath-hold at 9.6s average breath-hold time. Calculated depositions confirmed appropriate lung deposition of Symbicort(®) Turbuhaler(®) for both genders, however more effort for optimal inhalation technique is advised for persons with low vital capacity. This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations. The methodology developed in this study will be applicable also to other marketed drugs in the future.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088230"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088230"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088230; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088230]").text(description); $(".js-view-count[data-work-id=73088230]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088230; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088230']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088230, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73088230]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088230,"title":"Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug","translated_title":"","metadata":{"abstract":"One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive pulmonary disease (COPD) management is Symbicort(®) Turbuhaler(®). The aim of this study was to simulate the deposition distribution of both components of this drug within the airways based on realistic airflow measurements. Breathing parameters of 25 healthy adults (11 females and 14 males) were acquired while inhaling through Turbuhaler(®). Individual specific emitted doses and particle size distributions of Symbicort(®) Turbuhaler(®) were determined. A self-developed particle deposition model was adapted and validated to simulate the deposition of budesonide (inhaled corticosteroid; ICS) and formoterol (long acting β2 agonist; LABA) in the upper airways and lungs of the healthy volunteers. Based on current simulations the emitted doses varied between 50.4% and 92.5% of the metered dose for the ICS, and between 38% and 96.1% in case of LABA component depending on the individual inhalation flow rate. This variability induced a notable inter-individual spread of the deposited lung doses (mean: 33.6%, range: 20.4%-48.8% for budesonide and mean: 29.8%, range: 16.4%-42.9% for formoterol). Significant inter-gender differences were also observed. Average lung dose of budesonide was 29.2% of the metered dose for females and 37% for males, while formoterol deposited with 26.4% efficiency for females and 32.5% for males. Present results also highlighted the importance of breath-holding after inhalation of the drug. About a half of the total lung deposition occurred during breath-hold at 9.6s average breath-hold time. Calculated depositions confirmed appropriate lung deposition of Symbicort(®) Turbuhaler(®) for both genders, however more effort for optimal inhalation technique is advised for persons with low vital capacity. This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations. The methodology developed in this study will be applicable also to other marketed drugs in the future.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"European Journal of Pharmaceutical Sciences"},"translated_abstract":"One of the most widespread dry powder fixed combinations used in asthma and chronic obstructive pulmonary disease (COPD) management is Symbicort(®) Turbuhaler(®). The aim of this study was to simulate the deposition distribution of both components of this drug within the airways based on realistic airflow measurements. Breathing parameters of 25 healthy adults (11 females and 14 males) were acquired while inhaling through Turbuhaler(®). Individual specific emitted doses and particle size distributions of Symbicort(®) Turbuhaler(®) were determined. A self-developed particle deposition model was adapted and validated to simulate the deposition of budesonide (inhaled corticosteroid; ICS) and formoterol (long acting β2 agonist; LABA) in the upper airways and lungs of the healthy volunteers. Based on current simulations the emitted doses varied between 50.4% and 92.5% of the metered dose for the ICS, and between 38% and 96.1% in case of LABA component depending on the individual inhalation flow rate. This variability induced a notable inter-individual spread of the deposited lung doses (mean: 33.6%, range: 20.4%-48.8% for budesonide and mean: 29.8%, range: 16.4%-42.9% for formoterol). Significant inter-gender differences were also observed. Average lung dose of budesonide was 29.2% of the metered dose for females and 37% for males, while formoterol deposited with 26.4% efficiency for females and 32.5% for males. Present results also highlighted the importance of breath-holding after inhalation of the drug. About a half of the total lung deposition occurred during breath-hold at 9.6s average breath-hold time. Calculated depositions confirmed appropriate lung deposition of Symbicort(®) Turbuhaler(®) for both genders, however more effort for optimal inhalation technique is advised for persons with low vital capacity. This study demonstrated the possibility of personalized prediction of airway deposition of aerosol drugs by numerical simulations. The methodology developed in this study will be applicable also to other marketed drugs in the future.","internal_url":"https://www.academia.edu/73088230/Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug","translated_internal_url":"","created_at":"2022-03-05T01:51:08.193-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Numerical_simulation_of_emitted_particle_characteristics_and_airway_deposition_distribution_of_Symbicort_Turbuhaler_dry_powder_fixed_combination_aerosol_drug","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation"},{"id":172705,"name":"Dry Powder Inhalers","url":"https://www.academia.edu/Documents/in/Dry_Powder_Inhalers"},{"id":390245,"name":"Particle Size","url":"https://www.academia.edu/Documents/in/Particle_Size"},{"id":393958,"name":"Respiratory System","url":"https://www.academia.edu/Documents/in/Respiratory_System"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088229"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088229/A_sziszt%C3%A9m%C3%A1s_lupus_erythematosus_pulmonalis_manifeszt%C3%A1ci%C3%B3i"><img alt="Research paper thumbnail of A szisztémás lupus erythematosus pulmonalis manifesztációi" class="work-thumbnail" src="https://attachments.academia-assets.com/81747805/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088229/A_sziszt%C3%A9m%C3%A1s_lupus_erythematosus_pulmonalis_manifeszt%C3%A1ci%C3%B3i">A szisztémás lupus erythematosus pulmonalis manifesztációi</a></div><div class="wp-workCard_item"><span>Orvosi Hetilap</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Systemic lupus erythematosus is the most common connective tissue disease that is associated with...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Systemic lupus erythematosus is the most common connective tissue disease that is associated with pulmonary manifestations. Although lupus has the potential to affect any organ, lung involvement is observed during the course of the disease in most cases and it is prognostic for outcome. Pulmonary manifestations in lupus can be classified into five groups based on the anatomical involvement: pleura, lung parenchyma, bronchi and bronchioli, lung vasculature and respiratory muscles can be involved. The most common respiratory manifestations attributable to lupus are pleuritis with or without pleural effusion, pulmonary vascular disease, upper and lower airway dysfunction, parenchymal disease, and diaphragmatic dysfunction (shrinking lung syndrome). In this article the authors summarize lung involvement of lupus, its diagnosis, therapy and prognosis. Orv. Hetil., 2016, 157(29), 1154–1160.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="330f462589d24a94979ab0efa8984b0e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747805,"asset_id":73088229,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747805/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088229"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088229"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088229; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088229]").text(description); $(".js-view-count[data-work-id=73088229]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088229; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088229']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088229, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "330f462589d24a94979ab0efa8984b0e" } } $('.js-work-strip[data-work-id=73088229]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088229,"title":"A szisztémás lupus erythematosus pulmonalis manifesztációi","translated_title":"","metadata":{"abstract":"Systemic lupus erythematosus is the most common connective tissue disease that is associated with pulmonary manifestations. Although lupus has the potential to affect any organ, lung involvement is observed during the course of the disease in most cases and it is prognostic for outcome. Pulmonary manifestations in lupus can be classified into five groups based on the anatomical involvement: pleura, lung parenchyma, bronchi and bronchioli, lung vasculature and respiratory muscles can be involved. The most common respiratory manifestations attributable to lupus are pleuritis with or without pleural effusion, pulmonary vascular disease, upper and lower airway dysfunction, parenchymal disease, and diaphragmatic dysfunction (shrinking lung syndrome). In this article the authors summarize lung involvement of lupus, its diagnosis, therapy and prognosis. Orv. Hetil., 2016, 157(29), 1154–1160.","publisher":"Akademiai Kiado Zrt.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Orvosi Hetilap"},"translated_abstract":"Systemic lupus erythematosus is the most common connective tissue disease that is associated with pulmonary manifestations. Although lupus has the potential to affect any organ, lung involvement is observed during the course of the disease in most cases and it is prognostic for outcome. Pulmonary manifestations in lupus can be classified into five groups based on the anatomical involvement: pleura, lung parenchyma, bronchi and bronchioli, lung vasculature and respiratory muscles can be involved. The most common respiratory manifestations attributable to lupus are pleuritis with or without pleural effusion, pulmonary vascular disease, upper and lower airway dysfunction, parenchymal disease, and diaphragmatic dysfunction (shrinking lung syndrome). In this article the authors summarize lung involvement of lupus, its diagnosis, therapy and prognosis. Orv. Hetil., 2016, 157(29), 1154–1160.","internal_url":"https://www.academia.edu/73088229/A_sziszt%C3%A9m%C3%A1s_lupus_erythematosus_pulmonalis_manifeszt%C3%A1ci%C3%B3i","translated_internal_url":"","created_at":"2022-03-05T01:51:07.820-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38468981,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81747805,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747805/thumbnails/1.jpg","file_name":"3093912.pdf","download_url":"https://www.academia.edu/attachments/81747805/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_szisztemas_lupus_erythematosus_pulmona.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747805/3093912-libre.pdf?1646475984=\u0026response-content-disposition=attachment%3B+filename%3DA_szisztemas_lupus_erythematosus_pulmona.pdf\u0026Expires=1732749062\u0026Signature=GdEKba7mesho0L22qL6yWtnVi3--ws7mX3xniJd4KXpzsOb2Xndl5F~-~6UiDfrTnzEUDNypSkyXe5JzIDJAfGqSN5AFriBia52uOu0dBaS5fH4SI5NsB5GhAukwcwZthzo2609ynVo~434~4BklOzk6HzJ-v41GeWW3O9NMgV9JyDgABeRFmLAk6KWQuLCZIT-SZx-yxJMydwPHy47~lMQg7rZnJ2ZLwnFgzAAkhRt4ugE5IiEGjlu1z~nVz3nE0aVatPOqrE1UZUaqB5NFsUr149Z2NgNPpofhB2HNovBgYUio7WHOM8S6BKC2ORlJnH4L43bOcVB7Tx2s02qRew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_szisztémás_lupus_erythematosus_pulmonalis_manifesztációi","translated_slug":"","page_count":7,"language":"hu","content_type":"Work","owner":{"id":38468981,"first_name":"Veronika","middle_initials":null,"last_name":"Muller","page_name":"VeronikaMuller","domain_name":"independent","created_at":"2015-11-16T11:00:00.835-08:00","display_name":"Veronika Muller","url":"https://independent.academia.edu/VeronikaMuller"},"attachments":[{"id":81747805,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81747805/thumbnails/1.jpg","file_name":"3093912.pdf","download_url":"https://www.academia.edu/attachments/81747805/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_szisztemas_lupus_erythematosus_pulmona.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81747805/3093912-libre.pdf?1646475984=\u0026response-content-disposition=attachment%3B+filename%3DA_szisztemas_lupus_erythematosus_pulmona.pdf\u0026Expires=1732749062\u0026Signature=GdEKba7mesho0L22qL6yWtnVi3--ws7mX3xniJd4KXpzsOb2Xndl5F~-~6UiDfrTnzEUDNypSkyXe5JzIDJAfGqSN5AFriBia52uOu0dBaS5fH4SI5NsB5GhAukwcwZthzo2609ynVo~434~4BklOzk6HzJ-v41GeWW3O9NMgV9JyDgABeRFmLAk6KWQuLCZIT-SZx-yxJMydwPHy47~lMQg7rZnJ2ZLwnFgzAAkhRt4ugE5IiEGjlu1z~nVz3nE0aVatPOqrE1UZUaqB5NFsUr149Z2NgNPpofhB2HNovBgYUio7WHOM8S6BKC2ORlJnH4L43bOcVB7Tx2s02qRew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":66614,"name":"Systemic Lupus Erythematosus","url":"https://www.academia.edu/Documents/in/Systemic_Lupus_Erythematosus"},{"id":88062,"name":"Vasculitis","url":"https://www.academia.edu/Documents/in/Vasculitis"},{"id":102587,"name":"Pulmonary Embolism","url":"https://www.academia.edu/Documents/in/Pulmonary_Embolism"},{"id":115488,"name":"Lung Diseases","url":"https://www.academia.edu/Documents/in/Lung_Diseases"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis"},{"id":959089,"name":"Pleural Effusion","url":"https://www.academia.edu/Documents/in/Pleural_Effusion"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":2226523,"name":"Pulmonary circulation","url":"https://www.academia.edu/Documents/in/Pulmonary_circulation"},{"id":2579304,"name":"Pleurisy","url":"https://www.academia.edu/Documents/in/Pleurisy"},{"id":3063336,"name":"Respiratory function tests","url":"https://www.academia.edu/Documents/in/Respiratory_function_tests"},{"id":3671094,"name":"Respiratory insufficiency","url":"https://www.academia.edu/Documents/in/Respiratory_insufficiency"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088227"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088227/Asthma_COPD_overlap_szindr%C3%B3ma"><img alt="Research paper thumbnail of Asthma-COPD overlap szindróma" class="work-thumbnail" src="https://attachments.academia-assets.com/81747806/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088227/Asthma_COPD_overlap_szindr%C3%B3ma">Asthma-COPD overlap szindróma</a></div><div class="wp-workCard_item"><span>Orvosi Hetilap</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Obstructive lung diseases represent a major health problem worldwide due to their high prevalence...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma – chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. The aim of this review is to summarize the currently available literature focusi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bdca33b2bebf430c73ba60c121322415" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81747806,"asset_id":73088227,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81747806/download_file?st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NTQ2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73088227"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73088227"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73088227; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73088227]").text(description); $(".js-view-count[data-work-id=73088227]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73088227; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73088227']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73088227, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bdca33b2bebf430c73ba60c121322415" } } $('.js-work-strip[data-work-id=73088227]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73088227,"title":"Asthma-COPD overlap szindróma","translated_title":"","metadata":{"abstract":"Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma – chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. The aim of this review is to summarize the currently available literature focusi...","publisher":"Akademiai Kiado Zrt.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Orvosi Hetilap"},"translated_abstract":"Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma – chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73088225"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73088225/Circulating_periostin_level_in_asthmatic_pregnancy"><img alt="Research paper thumbnail of Circulating periostin level in asthmatic pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/81747807/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73088225/Circulating_periostin_level_in_asthmatic_pregnancy">Circulating periostin level in asthmatic pregnancy</a></div><div class="wp-workCard_item"><span>The Journal of asthma : official journal of the Association for the Care of Asthma</span><span>, Jan 24, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Asthma often complicates pregnancy and represents a risk for complications. Periostin is consider...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Asthma often complicates pregnancy and represents a risk for complications. Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy. Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. Plasma periostin levels were similar in the HNP and ANP (55.68 [37.21-67.20] vs. 45.25 [32.67-64.55], p &gt; 0.05), and elevated in the HP (68.81 [57.34-98.84] ng/mL, p = 0.02 vs. HNP) and AP groups (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). 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