CINXE.COM

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5.1724696046-473375462.1712005244" style="margin: 0 10px;" target="_blank"><img alt="Novus Biologicals products are now on bio-techne.com" src="https://images.novusbio.com/design/ready-to-buy-novus-products-login.png" style="height:120px; width:940px" /></a></div> </div> </div> </div> <h1>White papers</h1> </div> <div class="clear"></div> <div class="grid_16"> <div class="region region-content"> <div id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div id="node-379041" class="node node-page clearfix"> <div class="content"> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><h2><img src="//images.novusbio.com/design/irProtocols02.gif" align="left" style="margin-right:10px; margin-top:-10px; " alt="Novus Biologicals whitepapers">Research Focus</h2></br> <table border="0" cellspadding="8" cellspacing="8"> <tbody> <tr> <td valign="top" width="23%"> <a href="/whitepapers/hypoxia" target="_self"><img alt="The Cellular Response to Hypoxia in Cancer White Paper" src="https://images.novusbio.com/design/hypoxia1_WP.jpg" /></a></td> <td valign="top" width="27%"> <strong> <a href="/whitepapers/hypoxia" target="_self">The Cellular Response to Hypoxia in Cancer </a></strong> <p>Tissue hypoxia or low oxygenation shapes cellular adaptations in disease. In cancer, hypoxia via HIF proteins, induces molecular signaling pathways often leading to more aggressive tumor phenotypes. This review focuses on the role of HIFs as master regulators of hypoxia adaptations in cancer and highlights recent findings on the differential responses elicited by acute vs chronic hypoxia. </p> </td> <td valign="top" width="24%"> <a href="/whitepapers/understanding-the-cellular-response-to-hypoxia" target="_self"> <img alt="Cellular Response to Hypoxia through In Vitro Model Systems White Paper" src="https://images.novusbio.com/design/hypoxia2_WP2.2.jpg" align="center"/></a> </td> <td valign="top" width="26%"> <strong> <a href="/whitepapers/understanding-the-cellular-response-to-hypoxia" target="_self" > A Technical Perspective: Understanding the Cellular Response to Hypoxia through In Vitro Model Systems </a></strong> <p>The study of hypoxia and associated cellular adaptations in cancer has traditionally relied on the use of monolayer cultures which fail to duplicate in vivo tumor conditions. In contrast, 3D culture models simulate the natural tumor microenvironment. This review covers the benefits and caveats associated with several sphere culture models currently used to evaluate cellular responses to hypoxia in cancer. </p> </td> </tr> <tr> <td valign="top" width="23%"> <a href="/whitepapers/Autophagy-in-neurodegenerative-diseases" target="blank"> <img alt="Autophagy in Neurodegenerative Diseases White Paper" src="https://images.novusbio.com/design/neurodegenerativeWP.png" align="center"/></a> </td> <td valign="top" width="27%"> <strong> <a href="/whitepapers/Autophagy-in-neurodegenerative-diseases" target="blank" > Autophagy in Neurodegenerative Diseases </a> </strong> <p>Autophagy is the main pathway for the clearance of large protein aggregates present in Neurodegenerative Diseases. This review provides a comprehensive overview of molecular targets interconnecting the process of autophagy and neurodegeneration mechanisms.</p> </td> </tr> </tbody> </table> <h2><img src="//images.novusbio.com/design/irProtocols02.gif" align="left" style="margin-right:10px;margin-top:-10px; " alt="Novus Biologicals whitepapers">Application Focus</h2></br> <table border="0" cellspadding="8" cellspacing="8"> <tbody> <tr> <td valign="top" width="15%"> <a href="https://images.novusbio.com/design/Inducing-Autophagy-Tat-D11-a-highly-potent-and-specific-autophagy-inducing-peptide-Whitepaper.pdf" target="blank"> <img alt="Inducing Autophagy White Paper" src="https://images.novusbio.com/design/Autophagy_whitepages_img_Update.jpg" /></a> </td> <td valign="top" width="35%"> <strong> <a href="https://images.novusbio.com/design/Inducing-Autophagy-Tat-D11-a-highly-potent-and-specific-autophagy-inducing-peptide-Whitepaper.pdf" target="blank"> Inducing Autophagy: Tat-D11, a highly potent and specific autophagy-inducing peptide </a> </strong> <p>Tat-Beclin 1 D11 (Tat-D11) and Tat-Beclin 1 L11 (Tat-L11) peptides specifically induce autophagy preventing the activation of other biologically significant pathways and can be used both in vitro and in vivo. This white paper provides evidence of the vastly improved potency of a shorter Tat-Beclin 1 peptide, Tat-D11, to induce autophagy as evidenced by increased autophagosome and autolysosome numbers, relative to Tat-Beclin 1.</p> <td valign="top" width="15%"> <a href="https://images.novusbio.com/design/IHC_WP_030217_web.pdf" target="blank"><img alt="Improved Antigen Detection in IHC White Paper" src="https://images.novusbio.com/design/IHC_WP.png" /></a> </td> <td valign="top" width="35%"> <strong><a href="https://images.novusbio.com/design/IHC_WP_030217_web.pdf" target="_blank"> Improved Antigen Detection in IHC: Immunoassays utilizing HRP polymer conjugated secondary antibodies</a> </strong> <p>HRP polymer conjugates eliminate the major limitations of biotin-based IHC detection systems, reducing background staining and eliminating extra steps. 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