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drug</title> <meta name="description" content="Search results for: antiviral drug"> <meta name="keywords" content="antiviral drug"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="antiviral drug"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2104</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: antiviral drug</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2104</span> A Novel Peptide Showing Universal Effect against Multiple Viruses in Vitro and in Vivo</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hanjun%20Zhao">Hanjun Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Ke%20Zhang"> Ke Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Bojian%20Zheng"> Bojian Zheng </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: So far, there is no universal antiviral agent which can inhibit multiple viral infections. More and more drug-resistant viral strains emerge after the antiviral drug application for treatment. Defensins are the front line of host innate immunity and have broad spectrum antibacterial and antiviral effects. However, there is limited data to show if these defensins have good antiviral activity in vivo and what the antiviral mechanism is. Subjects: To investigate a peptide with widespread antivirus activity in vitro and in vivo and illustrate the antiviral mechanism. Methods: Antiviral peptide library designed from mouse beta defensins was synthesized by the company. Recombinant beta defensin was obtained from E. coli. Antiviral activity in vitro was assayed by plaque assay, qPCR. Antiviral activity in vivo was detected by animal challenge with 2009 pandemic H1N1 influenza A virus. The antiviral mechanism was assayed by western blot, ELISA, and qPCR. Conclusions: We identify a new peptide which has widespread effects against multiple viruses (H1N1, H5N1, H7N9, MERS-CoV) in vitro and has efficient antivirus activity in vivo. This peptide inhibits viral entry into target cells and subsequently blocks viral replication. The in vivo study of the antiviral peptide against other viral infections and the investigation of its more detail antiviral mechanism are ongoing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20peptide" title="antiviral peptide">antiviral peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=defensin" title=" defensin"> defensin</a>, <a href="https://publications.waset.org/abstracts/search?q=Influenza%20A%20virus" title=" Influenza A virus"> Influenza A virus</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanism" title=" mechanism"> mechanism</a> </p> <a href="https://publications.waset.org/abstracts/29172/a-novel-peptide-showing-universal-effect-against-multiple-viruses-in-vitro-and-in-vivo" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29172.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">400</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2103</span> In Silico Study of Antiviral Drugs Against Three Important Proteins of Sars-Cov-2 Using Molecular Docking Method</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alireza%20Jalalvand">Alireza Jalalvand</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Saleh"> Maryam Saleh</a>, <a href="https://publications.waset.org/abstracts/search?q=Somayeh%20Behjat%20Khatouni"> Somayeh Behjat Khatouni</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Bahri%20Najafi"> Zahra Bahri Najafi</a>, <a href="https://publications.waset.org/abstracts/search?q=Foroozan%20Fatahinia"> Foroozan Fatahinia</a>, <a href="https://publications.waset.org/abstracts/search?q=Narges%20Ismailzadeh"> Narges Ismailzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Behrokh%20Farahmand"> Behrokh Farahmand</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Object: In the last two decades, the recent outbreak of Coronavirus (SARS-CoV-2) imposed a global pandemic in the world. Despite the increasing prevalence of the disease, there are no effective drugs to treat it. A suitable and rapid way to afford an effective drug and treat the global pandemic is a computational drug study. This study used molecular docking methods to examine the potential inhibition of over 50 antiviral drugs against three fundamental proteins of SARS-CoV-2. METHODS: Through a literature review, three important proteins (a key protease, RNA-dependent RNA polymerase (RdRp), and spike) were selected as drug targets. Three-dimensional (3D) structures of protease, spike, and RdRP proteins were obtained from the Protein Data Bank. Protein had minimal energy. Over 50 antiviral drugs were considered candidates for protein inhibition and their 3D structures were obtained from drug banks. The Autodock 4.2 software was used to define the molecular docking settings and run the algorithm. RESULTS: Five drugs, including indinavir, lopinavir, saquinavir, nelfinavir, and remdesivir, exhibited the highest inhibitory potency against all three proteins based on the binding energies and drug binding positions deduced from docking and hydrogen-bonding analysis. Conclusions: According to the results, among the drugs mentioned, saquinavir and lopinavir showed the highest inhibitory potency against all three proteins compared to other drugs. It may enter laboratory phase studies as a dual-drug treatment to inhibit SARS-CoV-2. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=covid-19" title="covid-19">covid-19</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20repositioning" title=" drug repositioning"> drug repositioning</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=lopinavir" title=" lopinavir"> lopinavir</a>, <a href="https://publications.waset.org/abstracts/search?q=saquinavir" title=" saquinavir"> saquinavir</a> </p> <a href="https://publications.waset.org/abstracts/165518/in-silico-study-of-antiviral-drugs-against-three-important-proteins-of-sars-cov-2-using-molecular-docking-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165518.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">88</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2102</span> Phenolic Acids of Plant Origin as Promising Compounds for Elaboration of Antiviral Drugs against Influenza</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20Berezin">Vladimir Berezin</a>, <a href="https://publications.waset.org/abstracts/search?q=Aizhan%20Turmagambetova"> Aizhan Turmagambetova</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrey%20Bogoyavlenskiy"> Andrey Bogoyavlenskiy</a>, <a href="https://publications.waset.org/abstracts/search?q=Pavel%20Alexyuk"> Pavel Alexyuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Madina%20Alexyuk"> Madina Alexyuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Irina%20Zaitceva"> Irina Zaitceva</a>, <a href="https://publications.waset.org/abstracts/search?q=Nadezhda%20Sokolova"> Nadezhda Sokolova</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Influenza viruses could infect approximately 5% to 10% of the global human population annually, resulting in serious social and economic damage. Vaccination and etiotropic antiviral drugs are used for the prevention and treatment of influenza. Vaccination is important; however, antiviral drugs represent the second line of defense against new emerging influenza virus strains for which vaccines may be unsuccessful. However, the significant drawback of commercial synthetic anti-flu drugs is the appearance of drug-resistant influenza virus strains. Therefore, the search and development of new anti-flu drugs efficient against drug-resistant strains is an important medical problem for today. The aim of this work was a study of four phenolic acids of plant origin (Gallic, Syringic, Vanillic, and Protocatechuic acids) as a possible tool for treatment against influenza virus. Methods: Phenolic acids; gallic, syringic, vanillic, and protocatechuic have been prepared by extraction from plant tissues and purified using high-performance liquid chromatography fractionation. Avian influenza virus, strain A/Tern/South Africa/1/1961 (H5N3) and human epidemic influenza virus, strain A/Almaty/8/98 (H3N2) resistant to commercial anti-flu drugs (Rimantadine, Oseltamivir) were used for testing antiviral activity. Viruses were grown in the allantoic cavity of 10 days old chicken embryos. The chemotherapeutic index (CTI), determined as the ratio of an average toxic concentration of the tested compound (TC₅₀) to the average effective virus-inhibition concentration (EC₅₀), has been used as a criteria of specific antiviral action. Results: The results of study have shown that the structure of phenolic acids significantly affected their ability to suppress the reproduction of tested influenza virus strains. The highest antiviral activity among tested phenolic acids was detected for gallic acid, which contains three hydroxyl groups in the molecule at C3, C4, and C5 positions. Antiviral activity of gallic acid against A/H5N3 and A/H3N2 influenza virus strains was higher than antiviral activity of Oseltamivir and Rimantadine. gallic acid inhibited almost 100% of the infection activity of both tested viruses. Protocatechuic acid, which possesses 2 hydroxyl groups (C3 and C4) have shown weaker antiviral activity in comparison with gallic acid and inhibited less than 10% of virus infection activity. Syringic acid, which contains two hydroxyl groups (C3 and C5), was able to suppress up to 12% of infection activity. Substitution of two hydroxyl groups by methoxy groups resulted in the complete loss of antiviral activity. Vanillic acid, which is different from protocatechuic acid by replacing of C3 hydroxyl group to methoxy group, was able to suppress about 30% of infection activity of tested influenza viruses. Conclusion: For pronounced antiviral activity, the molecular of phenolic acid must have at least two hydroxyl groups. Replacement of hydroxyl groups to methoxy group leads to a reduction of antiviral properties. Gallic acid demonstrated high antiviral activity against influenza viruses, including Rimantadine and Oseltamivir resistant strains, and could be used as a potential candidate for the development of antiviral drug against influenza virus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20activity" title="antiviral activity">antiviral activity</a>, <a href="https://publications.waset.org/abstracts/search?q=influenza%20virus" title=" influenza virus"> influenza virus</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20resistance" title=" drug resistance"> drug resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20acids" title=" phenolic acids"> phenolic acids</a> </p> <a href="https://publications.waset.org/abstracts/118980/phenolic-acids-of-plant-origin-as-promising-compounds-for-elaboration-of-antiviral-drugs-against-influenza" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/118980.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">141</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2101</span> Inhibition of Mixed Infection Caused by Human Immunodeficiency Virus and Herpes Virus by Fullerene Compound</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dmitry%20Nosik">Dmitry Nosik</a>, <a href="https://publications.waset.org/abstracts/search?q=Nickolay%20Nosik"> Nickolay Nosik</a>, <a href="https://publications.waset.org/abstracts/search?q=Elli%20Kaplina"> Elli Kaplina</a>, <a href="https://publications.waset.org/abstracts/search?q=Olga%20Lobach"> Olga Lobach</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20Chataeva"> Marina Chataeva</a>, <a href="https://publications.waset.org/abstracts/search?q=Lev%20Rasnetsov"> Lev Rasnetsov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and aims: Human Immunodeficiency Virus (HIV) infection is very often associated with Herpes Simplex Virus (HSV) infection but HIV patients are treated with a cocktail of antiretroviral drugs which are toxic. The use of an antiviral drug which will be active against both viruses like ferrovir found in our previous studies is rather actual. Earlier we had shown that Fullerene poly-amino capronic acid (FPACA) was active in case of monoinfection of HIV-1 or HSV-1. The aim of the study was to analyze the efficiency of FPACA against mixed infection of HIV and HSV. Methods: The peripheral blood lymphocytes, CEM, MT-4 cells were simultaneously infected with HIV-1 and HSV-1. FPACA was added 1 hour before infection. Cells viability was detected by MTT assay, virus antigens detected by ELISA, syncytium formation detected by microscopy. The different multiplicity of HIV-1/HSV-1 ratio was used. Results: The double viral HIV-1/HSV-1 infection was more cytopathic comparing with monoinfections. In mixed infection by the HIV-1/HSV-1 concentration of HIV-1 antigens and syncytium formations increased by 1,7 to 2,3 times in different cells in comparison with the culture infected with HIV-1 alone. The concentration of HSV-1 increased by 1,5-1,7 times, respectively. Administration of FPACA (1 microg/ml) protected cells: HIV-1/HSV-1 (1:1) – 80,1%; HIV-1/HSV-1 (1:4) – 57,2%; HIV-1/HSV-1 (1:8) – 46,3 %; HIV-1/HSV-1 (1:16) – 17,0%. Virus’s antigen levels were also reduced. Syncytium formation was totally inhibited in all cases of mixed infection. Conclusion: FPACA showed antiviral activity in case of mixed viral infection induced by Human Immunodeficiency Virus and Herpes Simplex Virus. The effect of viral inhibition increased with the multiplicity of HIV-1 in the inoculum. The mechanism of FPACA action is connected with the blocking of the virus particles adsorption to the cells and it could be suggested that it can have an antiviral activity against some other viruses too. Now FPACA could be considered as a potential drug for treatment of HIV disease complicated with opportunistic herpes viral infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20drug" title="antiviral drug">antiviral drug</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20immunodeficiency%20virus%20%28hiv%29" title=" human immunodeficiency virus (hiv)"> human immunodeficiency virus (hiv)</a>, <a href="https://publications.waset.org/abstracts/search?q=herpes%20simplex%20virus%20%28hsv%29" title=" herpes simplex virus (hsv)"> herpes simplex virus (hsv)</a>, <a href="https://publications.waset.org/abstracts/search?q=mixed%20viral%20infection" title=" mixed viral infection"> mixed viral infection</a> </p> <a href="https://publications.waset.org/abstracts/29635/inhibition-of-mixed-infection-caused-by-human-immunodeficiency-virus-and-herpes-virus-by-fullerene-compound" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29635.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">343</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2100</span> A Small-Molecular Inhibitor of Influenza Virus via Disrupting the PA and PB1 Interaction of the Viral Polymerase</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shuofeng%20Yuan">Shuofeng Yuan</a>, <a href="https://publications.waset.org/abstracts/search?q=Bojian%20Zheng"> Bojian Zheng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Assembly of the heterotrimeric polymerase complex of influenza virus from the individual subunits PB1, PA, and PB2 is a prerequisite for viral replication, in which the interaction between the N-terminal of PB1 (PB1N) and the C terminal of PA (PAC) may be a desired target for antiviral development. In this study, we first compared the feasibility of high throughput screening by enzyme-linked immunosorbent assay (ELISA) and fluorescence polarization (FP) assay. Among the two, ELISA was demonstrated to own broader dynamic range so that it was used for screening inhibitors, which blocked PA and PB1 interaction. Several binding inhibitors of PAC-PB1N were identified and subsequently tested for the antiviral efficacy. Apparently, 3-(2-chlorophenyl)-6-ethyl-7-methyl[1,2,4]triazolo[4,3-a]pyrimidin-5-ol, designated ANA-1, was found to be a strong inhibitor of PAC-PB1N interaction and act as a potent antiviral agent against the infections of multiple subtypes of influenza A virus, including H1N1, H3N2, H5N1, H7N7, H7N9 and H9N2 subtypes, in cell cultures. Intranasal administration of ANA-1 protected mice from lethal challenge and reduced lung viral loads in H1N1 virus infected BALB/c mice. Docking analyses predicted that ANA-1 bound to an allosteric site of PAC, which would cause conformational changes thereby disrupting the PAC-PB1N interaction. Overall, our study has identified a novel compound with potential to be developed as an anti-influenza drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=influenza" title="influenza">influenza</a>, <a href="https://publications.waset.org/abstracts/search?q=antiviral" title=" antiviral"> antiviral</a>, <a href="https://publications.waset.org/abstracts/search?q=viral%20polymerase" title=" viral polymerase"> viral polymerase</a>, <a href="https://publications.waset.org/abstracts/search?q=compounds" title=" compounds"> compounds</a> </p> <a href="https://publications.waset.org/abstracts/38070/a-small-molecular-inhibitor-of-influenza-virus-via-disrupting-the-pa-and-pb1-interaction-of-the-viral-polymerase" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38070.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">347</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2099</span> The importance of Clinical Pharmacy and Computer Aided Drug Design</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Peter%20Edwar%20Mortada%20Nasif">Peter Edwar Mortada Nasif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of CAD (Computer Aided Design) technology is ubiquitous in the architecture, engineering and construction (AEC) industry. This has led to its inclusion in the curriculum of architecture schools in Nigeria as an important part of the training module. This article examines the ethical issues involved in implementing CAD (Computer Aided Design) content into the architectural education curriculum. Using existing literature, this study begins with the benefits of integrating CAD into architectural education and the responsibilities of different stakeholders in the implementation process. It also examines issues related to the negative use of information technology and the perceived negative impact of CAD use on design creativity. Using a survey method, data from the architecture department of Chukwuemeka Odumegwu Ojukwu Uli University was collected to serve as a case study on how the issues raised were being addressed. The article draws conclusions on what ensures successful ethical implementation. Millions of people around the world suffer from hepatitis C, one of the world's deadliest diseases. Interferon (IFN) is treatment options for patients with hepatitis C, but these treatments have their side effects. Our research focused on developing an oral small molecule drug that targets hepatitis C virus (HCV) proteins and has fewer side effects. Our current study aims to develop a drug based on a small molecule antiviral drug specific for the hepatitis C virus (HCV). Drug development using laboratory experiments is not only expensive, but also time-consuming to conduct these experiments. Instead, in this in silicon study, we used computational techniques to propose a specific antiviral drug for the protein domains of found in the hepatitis C virus. This study used homology modeling and abs initio modeling to generate the 3D structure of the proteins, then identifying pockets in the proteins. Acceptable lagans for pocket drugs have been developed using the de novo drug design method. Pocket geometry is taken into account when designing ligands. Among the various lagans generated, a new specific for each of the HCV protein domains has been proposed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20design" title="drug design">drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-viral%20drug" title=" anti-viral drug"> anti-viral drug</a>, <a href="https://publications.waset.org/abstracts/search?q=in-silicon%20drug%20design" title=" in-silicon drug design"> in-silicon drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatitis%20C%20virus" title=" hepatitis C virus"> hepatitis C virus</a>, <a href="https://publications.waset.org/abstracts/search?q=computer%20aided%20design" title=" computer aided design"> computer aided design</a>, <a href="https://publications.waset.org/abstracts/search?q=CAD%20education" title=" CAD education"> CAD education</a>, <a href="https://publications.waset.org/abstracts/search?q=education%20improvement" title=" education improvement"> education improvement</a>, <a href="https://publications.waset.org/abstracts/search?q=small-size%20contractor%20automatic%20pharmacy" title=" small-size contractor automatic pharmacy"> small-size contractor automatic pharmacy</a>, <a href="https://publications.waset.org/abstracts/search?q=PLC" title=" PLC"> PLC</a>, <a href="https://publications.waset.org/abstracts/search?q=control%20system" title=" control system"> control system</a>, <a href="https://publications.waset.org/abstracts/search?q=management%20system" title=" management system"> management system</a>, <a href="https://publications.waset.org/abstracts/search?q=communication" title=" communication"> communication</a> </p> <a href="https://publications.waset.org/abstracts/188179/the-importance-of-clinical-pharmacy-and-computer-aided-drug-design" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188179.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">22</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2098</span> The Impact of Artificial Intelligence on Medicine Production</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yasser%20Ahmed%20Mahmoud%20Ali%20Helal">Yasser Ahmed Mahmoud Ali Helal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of CAD (Computer Aided Design) technology is ubiquitous in the architecture, engineering and construction (AEC) industry. This has led to its inclusion in the curriculum of architecture schools in Nigeria as an important part of the training module. This article examines the ethical issues involved in implementing CAD (Computer Aided Design) content into the architectural education curriculum. Using existing literature, this study begins with the benefits of integrating CAD into architectural education and the responsibilities of different stakeholders in the implementation process. It also examines issues related to the negative use of information technology and the perceived negative impact of CAD use on design creativity. Using a survey method, data from the architecture department of University was collected to serve as a case study on how the issues raised were being addressed. The article draws conclusions on what ensures successful ethical implementation. Millions of people around the world suffer from hepatitis C, one of the world's deadliest diseases. Interferon (IFN) is treatment options for patients with hepatitis C, but these treatments have their side effects. Our research focused on developing an oral small molecule drug that targets hepatitis C virus (HCV) proteins and has fewer side effects. Our current study aims to develop a drug based on a small molecule antiviral drug specific for the hepatitis C virus (HCV). Drug development using laboratory experiments is not only expensive, but also time-consuming to conduct these experiments. Instead, in this in silicon study, we used computational techniques to propose a specific antiviral drug for the protein domains of found in the hepatitis C virus. This study used homology modeling and abs initio modeling to generate the 3D structure of the proteins, then identifying pockets in the proteins. Acceptable lagans for pocket drugs have been developed using the de novo drug design method. Pocket geometry is taken into account when designing ligands. Among the various lagans generated, a new specific for each of the HCV protein domains has been proposed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20design" title="drug design">drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-viral%20drug" title=" anti-viral drug"> anti-viral drug</a>, <a href="https://publications.waset.org/abstracts/search?q=in-silicon%20drug%20design" title=" in-silicon drug design"> in-silicon drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatitis%20C%20virus%20%28HCV%29%20%20CAD%20%28Computer%20Aided%20Design%29" title=" hepatitis C virus (HCV) CAD (Computer Aided Design)"> hepatitis C virus (HCV) CAD (Computer Aided Design)</a>, <a href="https://publications.waset.org/abstracts/search?q=CAD%20education" title=" CAD education"> CAD education</a>, <a href="https://publications.waset.org/abstracts/search?q=education%20improvement" title=" education improvement"> education improvement</a>, <a href="https://publications.waset.org/abstracts/search?q=small-size%20contractor%20automatic%20pharmacy" title=" small-size contractor automatic pharmacy"> small-size contractor automatic pharmacy</a>, <a href="https://publications.waset.org/abstracts/search?q=PLC" title=" PLC"> PLC</a>, <a href="https://publications.waset.org/abstracts/search?q=control%20system" title=" control system"> control system</a>, <a href="https://publications.waset.org/abstracts/search?q=management%20system" title=" management system"> management system</a>, <a href="https://publications.waset.org/abstracts/search?q=communication" title=" communication"> communication</a> </p> <a href="https://publications.waset.org/abstracts/183104/the-impact-of-artificial-intelligence-on-medicine-production" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/183104.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">83</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2097</span> The Importance of Clinical Pharmacy and Computer Aided Drug Design</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mario%20Hanna%20Louis%20Hanna">Mario Hanna Louis Hanna</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of CAD (pc Aided layout) generation is ubiquitous inside the structure, engineering and construction (AEC) industry. This has led to its inclusion in the curriculum of structure faculties in Nigeria as an important part of the training module. This newsletter examines the moral troubles involved in implementing CAD (pc Aided layout) content into the architectural training curriculum. Using current literature, this study begins with the advantages of integrating CAD into architectural education and the responsibilities of various stakeholders in the implementation process. It also examines issues related to the terrible use of records generation and the perceived bad effect of CAD use on design creativity. The use of a survey technique, information from the architecture department of Chukwuemeka Odumegwu Ojukwu Uli college changed into accumulated to serve as a case observe on how the problems raised have been being addressed. The object draws conclusions on what guarantees a hit moral implementation. Tens of millions of human beings around the sector suffer from hepatitis C, one of the international's deadliest sicknesses. Interferon (IFN) is a remedy alternative for patients with hepatitis C, but these treatments have their aspect outcomes. Our research targeted growing an oral small molecule drug that goals hepatitis C virus (HCV) proteins and has fewer facet effects. Our contemporary study targets to broaden a drug primarily based on a small molecule antiviral drug precise for the hepatitis C virus (HCV). Drug improvement and the use of laboratory experiments isn't always best high-priced, however also time-eating to behavior those experiments. instead, on this in silicon have a look at, we used computational strategies to recommend a particular antiviral drug for the protein domain names of discovered in the hepatitis C virus. This examines used homology modeling and abs initio modeling to generate the 3-D shape of the proteins, then figuring out pockets within the proteins. Proper lagans for pocket pills were advanced the usage of the de novo drug design method. Pocket geometry is taken into consideration while designing ligands. A few of the various lagans generated, a different for each of the HCV protein domains has been proposed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20design" title="drug design">drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-viral%20drug" title=" anti-viral drug"> anti-viral drug</a>, <a href="https://publications.waset.org/abstracts/search?q=in-silicon%20drug%20design" title=" in-silicon drug design"> in-silicon drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=Hepatitis%20C%20virus%20%28HCV%29%20%20CAD%20%28Computer%20Aided%20Design%29" title=" Hepatitis C virus (HCV) CAD (Computer Aided Design)"> Hepatitis C virus (HCV) CAD (Computer Aided Design)</a>, <a href="https://publications.waset.org/abstracts/search?q=CAD%20education" title=" CAD education"> CAD education</a>, <a href="https://publications.waset.org/abstracts/search?q=education%20improvement" title=" education improvement"> education improvement</a>, <a href="https://publications.waset.org/abstracts/search?q=small-size%20contractor%20automatic%20pharmacy" title=" small-size contractor automatic pharmacy"> small-size contractor automatic pharmacy</a>, <a href="https://publications.waset.org/abstracts/search?q=PLC" title=" PLC"> PLC</a>, <a href="https://publications.waset.org/abstracts/search?q=control%20system" title=" control system"> control system</a>, <a href="https://publications.waset.org/abstracts/search?q=management%20system" title=" management system"> management system</a>, <a href="https://publications.waset.org/abstracts/search?q=communication." title=" communication."> communication.</a> </p> <a href="https://publications.waset.org/abstracts/189433/the-importance-of-clinical-pharmacy-and-computer-aided-drug-design" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189433.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">27</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2096</span> Distinct Antiviral Pathway for ZFP36-Like Family Members Against Flavivirus Infection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ren-Jye%20Lin">Ren-Jye Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Li-Hsiung%20Lin"> Li-Hsiung Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Bing-Cheng%20Liu"> Bing-Cheng Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Ching-Len%20Liao"> Ching-Len Liao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The human zinc finger protein 36-like protein family, containing zinc finger protein 36-like 1 (ZFP36L1) and zinc finger protein 36-like 2 (ZFP36L2), belongs to CCCH-type zinc-finger protein identified as an RNA-binding protein that participates in controlling posttranscriptional regulation via RNA decay pathways. Recently, we demonstrated that human ZFP36L1 showed potent antiviral activity against flavivirus Infection by both 5´-3´ XRN1 and 3´-5´RNA-exosome RNA decay pathways (Journal of Virology 2022 Jan 12;96(1): e0166521). However, another zinc finger protein 36-like protein member, ZFP36L2, in the host defense response against flaviviruses has yet to be addressed. Here, we also demonstrate that ZFP36L2 functions as a host innate defender against flaviviruses, including Japanese encephalitis virus (JEV) and dengue virus (DENV). Overexpression of ZFP36L2 reduced JEV and DENV infection, and ZFP36L2 knockdown significantly promoted viral replication. Distinct from the antiviral mechanism of ZFP36L1, ZFP36L2 inhibits flavivirus infection by only a 5´-3´ XRN1-mediated RNA decay pathway but not the 3´-5´RNA-exosome RNA decay pathway. Human ZFP36L1 and ZFP36L2 can restrict flavivirus replication by directly binding and destabilizing viral RNA. Thus, for the first time, human zinc finger protein 36-like family members, ZFP36L1 and ZFP36L2, are identified as host antiviral factors that can bind and degrade flavivirus viral RNA by diverse antiviral mechanisms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ZFP36L1" title="ZFP36L1">ZFP36L1</a>, <a href="https://publications.waset.org/abstracts/search?q=ZFP36L2" title=" ZFP36L2"> ZFP36L2</a>, <a href="https://publications.waset.org/abstracts/search?q=5%27-3%27%20exonuclease%20XRN1" title=" 5'-3' exonuclease XRN1"> 5'-3' exonuclease XRN1</a>, <a href="https://publications.waset.org/abstracts/search?q=antiviral%20mechansim" title=" antiviral mechansim"> antiviral mechansim</a> </p> <a href="https://publications.waset.org/abstracts/166251/distinct-antiviral-pathway-for-zfp36-like-family-members-against-flavivirus-infection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166251.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">78</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2095</span> Correlation of Structure and Antiviral Activity of Alkaloids of Polygonum L. Plants Growing in Kazakhstan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dmitry%20Yu.%20Korulkin">Dmitry Yu. Korulkin</a>, <a href="https://publications.waset.org/abstracts/search?q=Raissa%20A.%20Muzychkina"> Raissa A. Muzychkina</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Currently to treat infectious diseases bioactive substances of plant origin having fewer side effects than synthetic medicines and medicines similar to natural components of a human body by the structure and action, become very important. One of the groups of secondary metabolites of the plants - alkaloids can be related the number of the most promising sources of medicines of plant origin. Currently, the structure of more than 7500 compounds has been identified. Analyzing the scope of research in the field of chemistry, pharmacology and technology of alkaloids, we can make a conclusion about that there is no system approach during the research of relation structure-activity on different groups of these substances. It is connected not only with a complex structure of their molecules, but also with insufficient information on the nature of their effect on organs, tissues and other targets in organism. The purpose of this research was to identify pharmacophore groups in the structure of alkaloids of endemic Polygonum L. plants growing in Kazakhstan responsible for their antiviral action. To isolate alkaloids pharmacopoeian methods were used. Antiviral activity of alkaloids of Polygonum L. plants was researched in the Institute of Microbiology and Virology of the Ministry of Education and Science of the Republic of Kazakhstan. Virus-inhibiting properties of compounds were studies in experiments with ortho- and paramyxoviruses on the model of chick-embryos. Anti-viral properties were determined using ‘screening test’ method designed to neutralization of a virus at the amount of 100EID50 with set concentrations of medicines. The difference of virus titer compared to control group was deemed as the criterion of antiviral action. It has been established that Polygonum L. alkaloids has high antiviral effect to influenza and parainfluenza viruses. The analysis of correlation of the structure and antiviral activity of alkaloids allowed identifying the main pharmacophore groups, among which the most important are glycosidation, the presence of carbonyl and hydroxyl groups, molecular weight and molecular size. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alkaloids" title="alkaloids">alkaloids</a>, <a href="https://publications.waset.org/abstracts/search?q=antiviral" title=" antiviral"> antiviral</a>, <a href="https://publications.waset.org/abstracts/search?q=bioactive%20substances" title=" bioactive substances"> bioactive substances</a>, <a href="https://publications.waset.org/abstracts/search?q=isolation" title=" isolation"> isolation</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacophore%20groups" title=" pharmacophore groups"> pharmacophore groups</a>, <a href="https://publications.waset.org/abstracts/search?q=Polygonum%20L." title=" Polygonum L."> Polygonum L.</a> </p> <a href="https://publications.waset.org/abstracts/28281/correlation-of-structure-and-antiviral-activity-of-alkaloids-of-polygonum-l-plants-growing-in-kazakhstan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28281.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">437</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2094</span> Synthesis and Molecular Docking Studies of Hydrazone Derivatives Potent Inhibitors as a Human Carbonic Anhydrase IX</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sema%20%C5%9Eeno%C4%9Flu">Sema Şenoğlu</a>, <a href="https://publications.waset.org/abstracts/search?q=Sevgi%20Karaku%C5%9F"> Sevgi Karakuş</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrazone scaffold is important to design new drug groups and is found to possess numerous uses in pharmaceutical chemistry. Besides, hydrazone derivatives are also known for biological activities such as anticancer, antimicrobial, antiviral, and antifungal. Hydrazone derivatives are promising anticancer agents because they inhibit cancer proliferation and induce apoptosis. Human carbonic anhydrase IX has a high potential to be an antiproliferative drug target, and targeting this protein is also important for obtaining potential anticancer inhibitors. The protein construct was retrieved as a PDB file from the RCSB protein database. This binding interaction of proteins and ligands was performed using Discovery Studio Visualizer. In vitro inhibitory activity of hydrazone derivatives was tested against enzyme carbonic anhydrase IX on the PyRx programme. Most of these molecules showed remarkable human carbonic anhydrase IX inhibitory activity compared to the acetazolamide. As a result, these compounds appear to be a potential target in drug design against human carbonic anhydrase IX. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer" title="cancer">cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=carbonic%20anhydrase%20IX%20enzyme" title=" carbonic anhydrase IX enzyme"> carbonic anhydrase IX enzyme</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrazone" title=" hydrazone"> hydrazone</a> </p> <a href="https://publications.waset.org/abstracts/171356/synthesis-and-molecular-docking-studies-of-hydrazone-derivatives-potent-inhibitors-as-a-human-carbonic-anhydrase-ix" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171356.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2093</span> Dual-functional Peptide With Defective Interfering Genes Protecting Mice From Avian and Seasonal Influenza Virus Infection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hanjun%20Zhao">Hanjun Zhao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Limited efficacy of current antivirals and antiviral-resistant mutations impair anti-influenza treatment. Here, we evaluated the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Virus replication was significantly reduced in 293T and A549 cells transfected with DIG-3. Mice transfected with DIG-3 encoded by jetPEI-vector, as prophylaxis and therapeutics against A(H7N7) virus respectively, had significantly better survivals (80% and 50%) than control mice (0%). We further developed a dual-functional peptide TAT-P1, which delivers DIG-3 with high transfection efficiency and concomitantly exerts antiviral activity by preventing endosomal acidification. TAT-P1/DIG-3 was more effective than jetPEI/DIG-3 in treating A(H7N7) or A(H1N1)pdm09-infected mice and showed potent prophylactic protection on A(H7N7) or A(H1N1)pdm09-infected mice. The addition of P1 peptide, preventing endosomal acidification, could enhance the protection of TAT-P1/DIG-3 on A(H1N1)pdm09-infected mice. Dual-functional TAT-P1 with DIG-3 can effectively protect or treat mice infected by avian and seasonal influenza virus infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20peptide" title="antiviral peptide">antiviral peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=dual-functional%20peptide" title=" dual-functional peptide"> dual-functional peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=defective%20interfering%20genes" title=" defective interfering genes"> defective interfering genes</a>, <a href="https://publications.waset.org/abstracts/search?q=influenza%20virus" title=" influenza virus"> influenza virus</a> </p> <a href="https://publications.waset.org/abstracts/98170/dual-functional-peptide-with-defective-interfering-genes-protecting-mice-from-avian-and-seasonal-influenza-virus-infection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98170.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2092</span> Nagami Kumkuat: A Source of Antiviral and Antimicrobial Bioactive Compounds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Howaida%20I.%20Abd-Alla">Howaida I. Abd-Alla</a>, <a href="https://publications.waset.org/abstracts/search?q=Nagwa%20M.%20M.%20Shalaby"> Nagwa M. M. Shalaby</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The fruit rind of Fortunella margarita (Nagami Kumkuat) was investigated for its chemical constituents. Thirteen metabolites were obtained and classified into, a sterol; β-sitosterol (1) and twelve phenolic compounds, three coumarins; xanthotoxin (2), isopimpinellin (3), umbelliferone (4), nine flavonoids of O-glycosides of flavone; apigenin-7-O-β-D-glucopyranoside (5), apigenin-7-O-rhamnoglucoside (rhoifolin) (6), C-glycosides; vitexin (7), vicenin II (8), and the methoxylated; 6-methoxyapigenin-7-methyl ether (9) and tangeretin (10) as well as flavanones class; naringenin (11), liquiritigenin (12), hesperdin (hesperetin-7-rhamnoglucoside) (13). All compounds were identified for the first time in F. margarita except compound (8). The major glycosides 5, 6, and 13 and total crude extract showed potential antiviral activity against live Newcastle disease virus vaccine strains (Komarov and LaSota) and live infectious bursitis viruses vaccine strain D78 replication in VERO cell cultures and on specific pathogen-free embryonated chicken eggs. Antiviral inhibitory concentration fifty (IC50), cytotoxic concentration fifty (CC50), and therapeutic index (TI) were calculated. In addition, the extract and compounds 7 and 13 showed marked antimicrobial activity against different strains of fungi, Gram-positive and negative bacteria, including some foodborne pathogens of animal origin, caused human disease. These results suggested that the extract of F. margarita may be considered potentially useful as a source of natural antiviral and antimicrobial agents. It can be used as an ingredient for functional food and/or pharmaceuticals. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title="antimicrobial">antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=antiviral" title=" antiviral"> antiviral</a>, <a href="https://publications.waset.org/abstracts/search?q=Fortunella%20margarita" title=" Fortunella margarita"> Fortunella margarita</a>, <a href="https://publications.waset.org/abstracts/search?q=Nagami%20Kumkuat" title=" Nagami Kumkuat"> Nagami Kumkuat</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20secondary%20metabolites" title=" phenolic secondary metabolites"> phenolic secondary metabolites</a> </p> <a href="https://publications.waset.org/abstracts/140746/nagami-kumkuat-a-source-of-antiviral-and-antimicrobial-bioactive-compounds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">206</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2091</span> Screening of Antiviral Compounds in Medicinal Plants: Non-Volatiles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tomas%20Drevinskas">Tomas Drevinskas</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruta%20Mickiene"> Ruta Mickiene</a>, <a href="https://publications.waset.org/abstracts/search?q=Audrius%20Maruska"> Audrius Maruska</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicola%20Tiso"> Nicola Tiso</a>, <a href="https://publications.waset.org/abstracts/search?q=Algirdas%20Salomskas"> Algirdas Salomskas</a>, <a href="https://publications.waset.org/abstracts/search?q=Raimundas%20Lelesius"> Raimundas Lelesius</a>, <a href="https://publications.waset.org/abstracts/search?q=Agneta%20Karpovaite"> Agneta Karpovaite</a>, <a href="https://publications.waset.org/abstracts/search?q=Ona%20Ragazinskiene"> Ona Ragazinskiene</a>, <a href="https://publications.waset.org/abstracts/search?q=Loreta%20Kubiliene"> Loreta Kubiliene</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Antiviral effect of substances accumulated by plants and natural products is known to ethno-pharmacy and modern day medicine. Antiviral properties are usually assigned to volatile compounds and polyphenols. This research work is divided into several parts and the task of this part was to investigate potential plants, potential substances and potential preparation conditions that can be used for the preparation of antiviral agents. Sixteen different medicinal plants, their parts and two types of propolis were selected for screening. Firstly, extraction conditions of non-volatile compounds were investigated: 3 pre-selected plants were extracted with 5 different ethanol – water mixtures (96%, 75%, 60%, 40%, 20 %, vol.) and bidistilled water. Total phenolic content, total flavonoid content and radical scavenging activity was determined. The results indicated that optimal extrahent is 40%, vol. of ethanol – water mixture. Further investigations were performed with the extrahent of 40%, vol. ethanol – water mixture. All 16 of selected plants, their parts and two types of propolis were extracted using selected extrahent. Determined total phenolic content, total flavonoid content and radical scavenging activity indicated that extracts of Origanum Vulgare L., Mentha piperita L., Geranium macrorrhizum L., Melissa officinalis L. and Desmodium canadence L. contains highest amount of extractable phenolic compounds (7.31, 5.48, 7.88, 8.02 and 7.16 rutin equivalents (mg/ ml) respectively), flavonoid content (2.14, 2.23, 2.49, 0.79 and 1.51 rutin equivalents (mg/ml) respectively) and radical scavenging activity (11.98, 8.72, 13.47, 13.22 and 12.22 rutin equivalents (mg/ml) respectively). Composition of the extracts is analyzed using HPLC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20effect" title="antiviral effect">antiviral effect</a>, <a href="https://publications.waset.org/abstracts/search?q=plants" title=" plants"> plants</a>, <a href="https://publications.waset.org/abstracts/search?q=propolis" title=" propolis"> propolis</a>, <a href="https://publications.waset.org/abstracts/search?q=phenols" title=" phenols"> phenols</a> </p> <a href="https://publications.waset.org/abstracts/50644/screening-of-antiviral-compounds-in-medicinal-plants-non-volatiles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50644.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">324</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2090</span> In Silico Studies on Selected Drug Targets for Combating Drug Resistance in Plasmodium Falcifarum </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Deepika%20Bhaskar">Deepika Bhaskar</a>, <a href="https://publications.waset.org/abstracts/search?q=Neena%20Wadehra"> Neena Wadehra</a>, <a href="https://publications.waset.org/abstracts/search?q=Megha%20Gulati"> Megha Gulati</a>, <a href="https://publications.waset.org/abstracts/search?q=Aruna%20Narula"> Aruna Narula</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Vishnu"> R. Vishnu</a>, <a href="https://publications.waset.org/abstracts/search?q=Gunjan%20Katyal"> Gunjan Katyal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> With drug resistance becoming widespread in Plasmodium falciparum infections, development of the alternative drugs is the desired strategy for prevention and cure of malaria. Three drug targets were selected to screen promising drug molecules from the GSK library of around 14000 molecules. Using an in silico structure-based drug designing approach, the differences in binding energies of the substrate and inhibitor were exploited between target sites of parasite and human to design a drug molecule against Plasmodium. The docking studies have shown several promising molecules from GSK library with more effective binding as compared to the already known inhibitors for the drug targets. Though stronger interaction has been shown by several molecules as compare to reference, few molecules have shown the potential as drug candidates though in vitro studies are required to validate the results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=plasmodium" title="plasmodium">plasmodium</a>, <a href="https://publications.waset.org/abstracts/search?q=malaria" title=" malaria"> malaria</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20targets" title=" drug targets"> drug targets</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20silico%20studies" title=" in silico studies"> in silico studies</a> </p> <a href="https://publications.waset.org/abstracts/24319/in-silico-studies-on-selected-drug-targets-for-combating-drug-resistance-in-plasmodium-falcifarum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24319.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">446</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2089</span> Potential Drug-Drug Interactions at a Referral Hematology-Oncology Ward in Iran: A Cross-Sectional Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sara%20Ataei">Sara Ataei</a>, <a href="https://publications.waset.org/abstracts/search?q=Molouk%20Hadjibabaie"> Molouk Hadjibabaie</a>, <a href="https://publications.waset.org/abstracts/search?q=Shirinsadat%20Badri"> Shirinsadat Badri</a>, <a href="https://publications.waset.org/abstracts/search?q=Amirhossein%20Moslehi"> Amirhossein Moslehi</a>, <a href="https://publications.waset.org/abstracts/search?q=Iman%20Karimzadeh"> Iman Karimzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ardeshir%20Ghavamzadeh"> Ardeshir Ghavamzadeh </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: To assess the pattern and probable risk factors for moderate and major drug–drug interactions in a referral hematology-oncology ward in Iran. Methods: All patients admitted to hematology–oncology ward of Dr. Shariati Hospital during a 6-month period and received at least two anti-cancer or non-anti-cancer medications simultaneously were included. All being scheduled anti-cancer and non-anti-cancer medications both prescribed and administered during ward stay were considered for drug–drug interaction screening by Lexi-Interact On- Desktop software. Results: One hundred and eighty-five drug–drug interactions with moderate or major severity were detected from 83 patients. Most of drug–drug interactions (69.73 %) were classified as pharmacokinetics. Fluconazole (25.95 %) was the most commonly offending medication in drug–drug interactions. Interaction of sulfamethoxazole-trimethoprim with fluconazole was the most common drug–drug interaction (27.27 %). Vincristine with imatinib was the only identified interaction between two anti-cancer agents. The number of administered medications during ward stay was considered as an independent risk factor for developing a drug–drug interaction. Conclusions: Potential moderate or major drug–drug interactions occur frequently in patients with hematological malignancies or related diseases. Performing larger standard studies are required to assess the real clinical and economical effects of drug–drug interactions on patients with hematological and non-hematological malignancies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%E2%80%93drug%20interactions" title="drug–drug interactions">drug–drug interactions</a>, <a href="https://publications.waset.org/abstracts/search?q=hematology%E2%80%93oncology%20ward" title=" hematology–oncology ward"> hematology–oncology ward</a>, <a href="https://publications.waset.org/abstracts/search?q=hematological%20malignancies" title=" hematological malignancies "> hematological malignancies </a> </p> <a href="https://publications.waset.org/abstracts/17983/potential-drug-drug-interactions-at-a-referral-hematology-oncology-ward-in-iran-a-cross-sectional-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17983.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2088</span> Drug Use Knowledge and Antimicrobial Drug Use Behavior</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pimporn%20Thongmuang">Pimporn Thongmuang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The import value of antimicrobial drugs reached approximately fifteen million Baht in 2010, considered as the highest import value of all modern drugs, and this value is rising every year. Antimicrobials are considered the hazardous drugs by the Ministry of Public Health. This research was conducted in order to investigate the past knowledge of drug use and Antimicrobial drug use behavior. A total of 757 students were selected as the samples out of a population of 1,800 students. This selected students had the experience of Antimicrobial drugs use a year ago. A questionnaire was utilized in this research. The findings put on the view that knowledge gained by the students about proper use of antimicrobial drugs was not brought into practice. This suggests that the education procedure regarding drug use needs adjustment. And therefore the findings of this research are expected to be utilized as guidelines for educating people about the proper use of antimicrobial drugs. At a broader perspective, correct drug use behavior of the public may potentially reduce drug cost of the Ministry of Public Health of Thailand. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20use%20knowledge" title="drug use knowledge">drug use knowledge</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20drugs" title=" antimicrobial drugs"> antimicrobial drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20use%20behavior" title=" drug use behavior"> drug use behavior</a>, <a href="https://publications.waset.org/abstracts/search?q=drug" title=" drug"> drug</a> </p> <a href="https://publications.waset.org/abstracts/3900/drug-use-knowledge-and-antimicrobial-drug-use-behavior" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3900.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">280</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2087</span> Early Transcriptome Responses to Piscine orthoreovirus-1 in Atlantic salmon Erythrocytes Compared to Salmonid Kidney Cell Lines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Thomais%20Tsoulia">Thomais Tsoulia</a>, <a href="https://publications.waset.org/abstracts/search?q=Arvind%20Y.%20M.%20Sundaram"> Arvind Y. M. Sundaram</a>, <a href="https://publications.waset.org/abstracts/search?q=Stine%20Braaen"> Stine Braaen</a>, <a href="https://publications.waset.org/abstracts/search?q=%C3%98yvind%20Haugland"> Øyvind Haugland</a>, <a href="https://publications.waset.org/abstracts/search?q=Espen%20Rimstad"> Espen Rimstad</a>, <a href="https://publications.waset.org/abstracts/search?q=%C3%98ystein%20%20Wessel"> Øystein Wessel</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20K.%20Dahle"> Maria K. Dahle</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fish red blood cells (RBC) are nucleated, and in addition to their function in gas exchange, they have been characterized as mediators of immune responses. Salmonid RBC are the major target cells of Piscineorthoreovirus (PRV), a virus associated with heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon. The activation of antiviral response genesin RBChas previously been described in ex vivo and in vivo PRV-infection models, but not explored in the initial virus encounter phase. In the present study, mRNA transcriptome responses were explored in erythrocytes from individual fish, kept ex vivo, and exposed to purified PRV for 24 hours. The responses were compared to responses in macrophage-like salmon head kidney (SHK-1) and endothelial-like Atlantic salmon kidney (ASK) cells, none of which support PRV replication. The comparative analysis showed that the antiviral response to PRV was strongest in the SHK-1 cells, with a set of 80 significantly induced genes (≥ 2-fold upregulation). In RBC, 46 genes were significantly upregulated, while ASK cells were not significantly responsive. In particular, the transcriptome analysis of RBC revealed that PRV significantly induced interferon regulatory factor 1 (IRF1) and interferon-induced protein with tetratricopeptide repeats 5-like (IFIT9). However, several interferon-regulated antiviral genes which have previously been reported upregulated in PRV infected RBC in vivo (myxovirus resistance (Mx), interferon-stimulated gene 15 (ISG15), toll-like receptor 3 (TLR3)), were not significantly induced after 24h of virus stimulation. In contrast to RBC, these antiviral response genes were significantly upregulated in SHK-1. These results confirm that RBC are involved in the innate immune response to viruses, but with a delayed antiviral response compared to SHK-1. A notable difference is that interferon regulatory factor 1 (IRF-1) is the most strongly induced gene in RBC, but not among the significantly induced genes in SHK-1. Putative differences in the binding, recognition, and response to PRV, and any link to effects on the ability of PRV to replicate remains to be explored. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20responses" title="antiviral responses">antiviral responses</a>, <a href="https://publications.waset.org/abstracts/search?q=atlantic%20salmon" title=" atlantic salmon"> atlantic salmon</a>, <a href="https://publications.waset.org/abstracts/search?q=piscine%20%20orthoreovirus-1" title=" piscine orthoreovirus-1"> piscine orthoreovirus-1</a>, <a href="https://publications.waset.org/abstracts/search?q=red%20blood%20cells" title=" red blood cells"> red blood cells</a>, <a href="https://publications.waset.org/abstracts/search?q=RNA-seq" title=" RNA-seq"> RNA-seq</a> </p> <a href="https://publications.waset.org/abstracts/144712/early-transcriptome-responses-to-piscine-orthoreovirus-1-in-atlantic-salmon-erythrocytes-compared-to-salmonid-kidney-cell-lines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144712.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">189</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2086</span> CRISPR Technology: A Tool in the Potential Cure for COVID-19 Virus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chijindu%20Okpalaoka">Chijindu Okpalaoka</a>, <a href="https://publications.waset.org/abstracts/search?q=Charles%20Chinedu%20Onuselogu"> Charles Chinedu Onuselogu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> COVID-19, humanity's coronavirus disease caused by SARS-CoV-2, was first detected in late 2019 in Wuhan, China. COVID-19 lacked an established conventional pharmaceutical therapy, and as a result, the outbreak quickly became an epidemic affecting the entire World. Only a qPCR assay is reliable for diagnosing COVID-19. Clustered, regularly interspaced short palindromic repeats (CRISPR) technology is being researched for speedy and specific identification of COVID-19, among other therapeutic techniques. Apart from its therapeutic capabilities, the CRISPR technique is being evaluated to develop antiviral therapies; nevertheless, no CRISPR-based medication has been approved for human use to date. Prophylactic antiviral CRISPR in living being cells, a Cas 13-based approach against coronavirus, has been developed. While this method can be evolved into a treatment approach, it may face substantial obstacles in human clinical trials for licensure. This study discussed the potential applications of CRISPR-based techniques for developing a speedy and accurate feasible treatment alternative for the COVID-19 virus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=COVID-19" title="COVID-19">COVID-19</a>, <a href="https://publications.waset.org/abstracts/search?q=CRISPR%20technique" title=" CRISPR technique"> CRISPR technique</a>, <a href="https://publications.waset.org/abstracts/search?q=Cas13" title=" Cas13"> Cas13</a>, <a href="https://publications.waset.org/abstracts/search?q=SARS-CoV-2" title=" SARS-CoV-2"> SARS-CoV-2</a>, <a href="https://publications.waset.org/abstracts/search?q=prophylactic%20antiviral" title=" prophylactic antiviral"> prophylactic antiviral</a> </p> <a href="https://publications.waset.org/abstracts/155310/crispr-technology-a-tool-in-the-potential-cure-for-covid-19-virus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155310.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2085</span> Preparation of Pegylated Interferon Alpha-2b with High Antiviral Activity Using Linear 20 KDa Polyethylene Glycol Derivative</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ehab%20El-Dabaa">Ehab El-Dabaa</a>, <a href="https://publications.waset.org/abstracts/search?q=Omnia%20Ali"> Omnia Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Abd%20El-Hady"> Mohamed Abd El-Hady</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Osman"> Ahmed Osman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recombinant human interferon alpha 2 (rhIFN-α2) is FDA approved for treatment of some viral and malignant diseases. Approved pegylated rhIFN-α2 drugs have highly improved pharmacokinetics, pharmacodynamics and therapeutic efficiency compared to native protein. In this work, we studied the pegylation of purified properly refolded rhIFN-α2b using linear 20kDa PEG-NHS (polyethylene glycol- N-hydroxysuccinimidyl ester) to prepare pegylated rhIFN-α2b with high stability and activity. The effect of different parameters like rhIFN-α2b final concentration, pH, rhIFN-α2b/PEG molar ratios and reaction time on the efficiency of pegylation (high percentage of monopegylated rhIFN-α2b) have been studied in small scale (100µl) pegylation reaction trials. Study of the percentages of different components of these reactions (mono, di, polypegylated rhIFN-α2b and unpegylated rhIFN-α2b) indicated that 2h is optimum time to complete the reaction. The pegylation efficiency increased at pH 8 (57.9%) by reducing the protein concentration to 1mg/ml and reducing the rhIFN-α2b/PEG ratio to 1:2. Using larger scale pegylation reaction (65% pegylation efficiency), ion exchange chromatography method has been optimized to prepare and purify the monopegylated rhIFN-α2b with high purity (96%). The prepared monopegylated rhIFN-α2b had apparent Mwt of approximately 65 kDa and high in vitro antiviral activity (2.1x10⁷ ± 0.8 x10⁷ IU/mg). Although it retained approximately 8.4 % of the antiviral activity of the unpegylated rhIFN-α2b, its activity is high compared to other pegylated rhIFN-α2 developed by using similar approach or higher molecular weight branched PEG. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20activity" title="antiviral activity">antiviral activity</a>, <a href="https://publications.waset.org/abstracts/search?q=rhIFN-%CE%B12b" title=" rhIFN-α2b"> rhIFN-α2b</a>, <a href="https://publications.waset.org/abstracts/search?q=pegylation" title=" pegylation"> pegylation</a>, <a href="https://publications.waset.org/abstracts/search?q=pegylation%20efficiency" title=" pegylation efficiency"> pegylation efficiency</a> </p> <a href="https://publications.waset.org/abstracts/82826/preparation-of-pegylated-interferon-alpha-2b-with-high-antiviral-activity-using-linear-20-kda-polyethylene-glycol-derivative" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82826.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">177</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2084</span> Medicinal Plants: An Antiviral Depository with Complex Mode of Action</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Daniel%20Todorov">Daniel Todorov</a>, <a href="https://publications.waset.org/abstracts/search?q=Anton%20Hinkov"> Anton Hinkov</a>, <a href="https://publications.waset.org/abstracts/search?q=Petya%20Angelova"> Petya Angelova</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalina%20Shishkova"> Kalina Shishkova</a>, <a href="https://publications.waset.org/abstracts/search?q=Venelin%20Tsvetkov"> Venelin Tsvetkov</a>, <a href="https://publications.waset.org/abstracts/search?q=Stoyan%20Shishkov"> Stoyan Shishkov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Human herpes viruses (HHV) are ubiquitous pathogens with a pandemic spread across the globe. HHV type 1 is the main causative agent of cold sores and fever blisters around the mouth and on the face, whereas HHV type 2 is generally responsible for genital herpes outbreaks. The treatment of both viruses is more or less successful with antivirals from the nucleoside analogues group. Their wide application increasingly leads to the emergence of resistant mutants In the past, medicinal plants have been used to treat a number of infectious and non-infectious diseases. Their diversity and ability to produce the vast variety of secondary metabolites according to the characteristics of the environment give them the potential to help us in our warfare with viral infections. The variable chemical characteristics and complex composition is an advantage in the treatment of herpes since the emergence of resistant mutants is significantly complicated. The screening process is difficult due to the lack of standardization. That is why it is especially important to follow the mechanism of antiviral action of plants. On the one hand, it may be expected to interact with its compounds, resulting in enhanced antiviral effects, and the most appropriate environmental conditions can be chosen to maximize the amount of active secondary metabolites. During our study, we followed the activity of various plant extracts on the viral replication cycle as well as their effect on the extracellular virion. We obtained our results following the logical sequence of the experimental settings - determining the cytotoxicity of the extracts, evaluating the overall effect on viral replication and extracellular virion.During our research, we have screened a variety of plant extracts for their antiviral activity against both virus replication and the virion itself. We investigated the effect of the extracts on the individual stages of the viral replication cycle - viral adsorption, penetration and the effect on replication depending on the time of addition. If there are positive results in the later experiments, we had studied the activity over viral adsorption, penetration and the effect of replication according to the time of addition. Our results indicate that some of the extracts from the Lamium album have several targets. The first stages of the viral life cycle are most affected. Several of our active antiviral agents have shown an effect on extracellular virion and adsorption and penetration processes. Our research over the last decade has shown several curative antiviral plants - some of which are from the Lamiacea family. The rich set of active ingredients of the plants in this family makes them a good source of antiviral preparation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20herpes%20virus" title="human herpes virus">human herpes virus</a>, <a href="https://publications.waset.org/abstracts/search?q=antiviral%20activity" title=" antiviral activity"> antiviral activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Lamium%20album" title=" Lamium album"> Lamium album</a>, <a href="https://publications.waset.org/abstracts/search?q=Nepeta%20nuda" title=" Nepeta nuda"> Nepeta nuda</a> </p> <a href="https://publications.waset.org/abstracts/90194/medicinal-plants-an-antiviral-depository-with-complex-mode-of-action" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90194.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">154</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2083</span> Drug-Drug Interaction Prediction in Diabetes Mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rashini%20Maduka">Rashini Maduka</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20R.%20Wijesinghe"> C. R. Wijesinghe</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20R.%20Weerasinghe"> A. R. Weerasinghe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Drug-drug interactions (DDIs) can happen when two or more drugs are taken together. Today DDIs have become a serious health issue due to adverse drug effects. In vivo and in vitro methods for identifying DDIs are time-consuming and costly. Therefore, in-silico-based approaches are preferred in DDI identification. Most machine learning models for DDI prediction are used chemical and biological drug properties as features. However, some drug features are not available and costly to extract. Therefore, it is better to make automatic feature engineering. Furthermore, people who have diabetes already suffer from other diseases and take more than one medicine together. Then adverse drug effects may happen to diabetic patients and cause unpleasant reactions in the body. In this study, we present a model with a graph convolutional autoencoder and a graph decoder using a dataset from DrugBank version 5.1.3. The main objective of the model is to identify unknown interactions between antidiabetic drugs and the drugs taken by diabetic patients for other diseases. We considered automatic feature engineering and used Known DDIs only as the input for the model. Our model has achieved 0.86 in AUC and 0.86 in AP. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug-drug%20interaction%20prediction" title="drug-drug interaction prediction">drug-drug interaction prediction</a>, <a href="https://publications.waset.org/abstracts/search?q=graph%20embedding" title=" graph embedding"> graph embedding</a>, <a href="https://publications.waset.org/abstracts/search?q=graph%20convolutional%20networks" title=" graph convolutional networks"> graph convolutional networks</a>, <a href="https://publications.waset.org/abstracts/search?q=adverse%20drug%20effects" title=" adverse drug effects"> adverse drug effects</a> </p> <a href="https://publications.waset.org/abstracts/165305/drug-drug-interaction-prediction-in-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165305.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2082</span> Spray-Dried, Biodegradable, Drug-Loaded Microspheres for Use in the Treatment of Lung Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazen%20AlGharsan">Mazen AlGharsan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The Carbopol Microsphere of Linezolid, a drug used to treat lung disease (pulmonary disease), was prepared using Buchi B-90 nano spray-drier. Methods: Production yield, drug content, external morphology, particle size, and in vitro release pattern were performed. Results: The work was 79.35%, and the drug content was 66.84%. The surface of the particles was shriveled in shape, with particle size distribution with a mean diameter of 9.6 µm; the drug was released in a biphasic manner with an initial release of 25.2 ± 5.7% at 60 minutes. It later prolonged the release by 95.5 ± 2.5% up to 12 hours. Differential scanning calorimetry (DSC) revealed no change in the melting point of the formulation. Fourier-transform infrared (FT-IR) studies showed no polymer-drug interaction in the prepared nanoparticles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title="nanotechnology">nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=Linezolid" title=" Linezolid"> Linezolid</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20disease" title=" lung disease"> lung disease</a> </p> <a href="https://publications.waset.org/abstracts/193025/spray-dried-biodegradable-drug-loaded-microspheres-for-use-in-the-treatment-of-lung-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193025.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">13</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2081</span> Artemisia Species from Iran as Valuable Resources for Medicinal Uses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Reza%20Naghavi">Mohammad Reza Naghavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Alaeimoghadam"> Farzad Alaeimoghadam</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Ghafoori"> Hossein Ghafoori</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Artemisia species, which are medically beneficial, are widespread in temperate regions of both Northern and Southern hemispheres among which Iran is located. About 35 species of Artemisia are indigenous in Iran among them some are widespread in all or most provinces, yet some are restricted to some specific regions. In this review paper, initially, GC-Mass results of some experiments done in different provinces of Iran are mentioned among them some compounds are common among species, some others are mostly restricted to other species; after that, medical advantages based on some researches on species of this genus are reviewed; different qualities such as anti-leishmania, anti-bacteria, antiviral as well as anti-proliferative could be mentioned. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=artemisia" title="artemisia">artemisia</a>, <a href="https://publications.waset.org/abstracts/search?q=GC-Mass%20analysis" title=" GC-Mass analysis"> GC-Mass analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20advantage" title=" medical advantage"> medical advantage</a>, <a href="https://publications.waset.org/abstracts/search?q=antiviral" title=" antiviral "> antiviral </a> </p> <a href="https://publications.waset.org/abstracts/13738/artemisia-species-from-iran-as-valuable-resources-for-medicinal-uses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13738.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">547</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2080</span> Role of Social Support in Drug Cessation among Male Addicts in the West of Iran</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Jalilian">Farzad Jalilian</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Mirzaei%20Alavijeh"> Mehdi Mirzaei Alavijeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Fazel%20Zinat%20Motlagh"> Fazel Zinat Motlagh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Social support is an important benchmark of health for people in avoidance conditions. The main goal of this study was to determine the three kinds of social support (family, friend and other significant) to drug cessation among male addicts, in Kermanshah, the west of Iran. This cross-sectional study was conducted among 132 addicts, randomly selected to participate voluntarily in the study. Data were collected from conduct interviews based on standard questionnaire and analyzed by using SPSS-18 at 95% significance level. The majority of addicts were young (Mean: 30.4 years), and with little education. Opium (36.4%), Crack (21.2%), and Methamphetamine (12.9%) were the predominant drugs. Inabilities to reject the offer and having addict friends are the most often reasons for drug usage. Almost, 18.9% reported history of drug injection. 43.2% of the participants already did drug cessation at least once. Logistic regression showed the family support (OR = 1.110), age (OR = 1.106) and drug use initiation age (OR = 0.918) was predicting drug cessation. Our result showed; family support is a more important effect among types of social support in drug cessation. It seems that providing educational program to addict’s families for more support of patients at drug cessation can be beneficial. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20cessation" title="drug cessation">drug cessation</a>, <a href="https://publications.waset.org/abstracts/search?q=family%20support" title=" family support"> family support</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20use" title=" drug use"> drug use</a>, <a href="https://publications.waset.org/abstracts/search?q=initiation%20age" title=" initiation age"> initiation age</a> </p> <a href="https://publications.waset.org/abstracts/33735/role-of-social-support-in-drug-cessation-among-male-addicts-in-the-west-of-iran" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33735.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">550</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2079</span> Functionalized Nanoparticles for Drug Delivery Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Temesgen%20Geremew">Temesgen Geremew</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Functionalized nanoparticles have emerged as a revolutionary platform for drug delivery, offering significant advantages over traditional methods. By strategically modifying their surface properties, these nanoparticles can be designed to target specific tissues and cells, significantly reducing off-target effects and enhancing therapeutic efficacy. This targeted approach allows for lower drug doses, minimizing systemic exposure and potential side effects. Additionally, functionalization enables controlled release of the encapsulated drug, improving drug stability and reducing the frequency of administration, leading to improved patient compliance. This work explores the immense potential of functionalized nanoparticles in revolutionizing drug delivery, addressing limitations associated with conventional therapies and paving the way for personalized medicine with precise and targeted treatment strategies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title="nanoparticles">nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=drug" title=" drug"> drug</a>, <a href="https://publications.waset.org/abstracts/search?q=nanomaterials" title=" nanomaterials"> nanomaterials</a>, <a href="https://publications.waset.org/abstracts/search?q=applications" title=" applications"> applications</a> </p> <a href="https://publications.waset.org/abstracts/183288/functionalized-nanoparticles-for-drug-delivery-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/183288.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">67</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2078</span> Ebola Virus Glycoprotein Inhibitors from Natural Compounds: Computer-Aided Drug Design</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Driss%20Cherqaoui">Driss Cherqaoui</a>, <a href="https://publications.waset.org/abstracts/search?q=Nouhaila%20Ait%20Lahcen"> Nouhaila Ait Lahcen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ismail%20Hdoufane"> Ismail Hdoufane</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Oubahmane"> Mehdi Oubahmane</a>, <a href="https://publications.waset.org/abstracts/search?q=Wissal%20Liman"> Wissal Liman</a>, <a href="https://publications.waset.org/abstracts/search?q=Christelle%20Delaite"> Christelle Delaite</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20M.%20Alanazi"> Mohammed M. Alanazi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Ebola virus is a highly contagious and deadly pathogen that causes Ebola virus disease. The Ebola virus glycoprotein (EBOV-GP) is a key factor in viral entry into host cells, making it a critical target for therapeutic intervention. Using a combination of computational approaches, this study focuses on the identification of natural compounds that could serve as potent inhibitors of EBOV-GP. The 3D structure of EBOV-GP was selected, with missing residues modeled, and this structure was minimized and equilibrated. Two large natural compound databases, COCONUT and NPASS, were chosen and filtered based on toxicity risks and Lipinski’s Rule of Five to ensure drug-likeness. Following this, a pharmacophore model, built from 22 reported active inhibitors, was employed to refine the selection of compounds with a focus on structural relevance to known Ebola inhibitors. The filtered compounds were subjected to virtual screening via molecular docking, which identified ten promising candidates (five from each database) with strong binding affinities to EBOV-GP. These compounds were then validated through molecular dynamics simulations to evaluate their binding stability and interactions with the target. The top three compounds from each database were further analyzed using ADMET profiling, confirming their favorable pharmacokinetic properties, stability, and safety. These results suggest that the selected compounds have the potential to inhibit EBOV-GP, offering new avenues for antiviral drug development against the Ebola virus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=EBOV-GP" title="EBOV-GP">EBOV-GP</a>, <a href="https://publications.waset.org/abstracts/search?q=Ebola%20virus%20glycoprotein" title=" Ebola virus glycoprotein"> Ebola virus glycoprotein</a>, <a href="https://publications.waset.org/abstracts/search?q=high-throughput%20drug%20screening" title=" high-throughput drug screening"> high-throughput drug screening</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics" title=" molecular dynamics"> molecular dynamics</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20compounds" title=" natural compounds"> natural compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacophore%20modeling" title=" pharmacophore modeling"> pharmacophore modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=virtual%20screening" title=" virtual screening"> virtual screening</a> </p> <a href="https://publications.waset.org/abstracts/192074/ebola-virus-glycoprotein-inhibitors-from-natural-compounds-computer-aided-drug-design" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192074.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">21</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2077</span> Pharmaceutical Science and Development in Drug Research</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adegoke%20Yinka%20Adebayo">Adegoke Yinka Adebayo </a> </p> <p class="card-text"><strong>Abstract:</strong></p> An understanding of the critical product attributes that impact on in vivo performance is key to the production of safe and effective medicines. Thus, a key driver for our research is the development of new basic science and technology underpinning the development of new pharmaceutical products. Research includes the structure and properties of drugs and excipients, biopharmaceutical characterisation, pharmaceutical processing and technology and formulation and analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20discovery" title="drug discovery">drug discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20development" title=" drug development"> drug development</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery "> drug delivery </a> </p> <a href="https://publications.waset.org/abstracts/19017/pharmaceutical-science-and-development-in-drug-research" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19017.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">494</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2076</span> Teicoplanin Derivatives with Antiviral Activity: Synthesis and Biological Evaluation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zsolt%20Szucs">Zsolt Szucs</a>, <a href="https://publications.waset.org/abstracts/search?q=Viktor%20Kelemen"> Viktor Kelemen</a>, <a href="https://publications.waset.org/abstracts/search?q=Son%20Le%20Thai"> Son Le Thai</a>, <a href="https://publications.waset.org/abstracts/search?q=Magdolna%20Csavas"> Magdolna Csavas</a>, <a href="https://publications.waset.org/abstracts/search?q=Erzsebet%20Roth"> Erzsebet Roth</a>, <a href="https://publications.waset.org/abstracts/search?q=Gyula%20Batta"> Gyula Batta</a>, <a href="https://publications.waset.org/abstracts/search?q=Annelies%20Stevaert"> Annelies Stevaert</a>, <a href="https://publications.waset.org/abstracts/search?q=Evelien%20Vanderlinden"> Evelien Vanderlinden</a>, <a href="https://publications.waset.org/abstracts/search?q=Aniko%20Borbas"> Aniko Borbas</a>, <a href="https://publications.waset.org/abstracts/search?q=Lieve%20Naesens"> Lieve Naesens</a>, <a href="https://publications.waset.org/abstracts/search?q=Pal%20Herczegh"> Pal Herczegh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The approval of modern glycopeptide antibiotics such as dalbavancin and oritavancin which have excellent activity against Gram-positive bacteria, encouraged our research group to prepare semisynthetic compounds from several members of glycopeptides by various chemical methods. Derivatives from the aglycone of ristocetin, eremomycin, vancomycin and a pseudoaglycon of teicoplanin have been synthesized in a systematic manner. Interestingly, some of the aglycoristocetin derivatives displayed noteworthy anti-influenza activity. More recently our group has been focusing on the modifications of one of the pseudoaglycons of teicoplanin. The reaction of N-ethoxycarbonyl maleimide derivatives with the primary amino function, the copper-catalysed azide-alkyne click reaction and the sulfonylation of the N-terminus were utilized to obtain systematic series of compounds. All substituents provide a more lipophilic character to the new molecules compared to the parent antibiotics, which is known to be favourable for activity against resistant bacteria. Lipoglycopeptides are also known to have antiviral properties, which has been predominantly studied on HIV by others. The structure-activity relationship study of our compounds revealed the influence of a few structural elements on biological activity. In many cases, minimal changes in lipophilicity and structure produced great differences in efficacy and cytotoxicity. In vitro experiments showed that these compounds are not only active against glycopeptide resistant Gram-positive bacteria but in several cases they prevent the infection of cell cultures by different strains of influenza viruses. This is probably related to the inhibition of the viral entry into the host cell nucleus, of which the exact mechanism is unknown. In some instances, reasonably low concentrations were sufficient to observe this effect. Several derivatives were highly cytotoxic at the same time, but some of them displayed a good selectivity index. The antiviral properties of the compounds are not restricted to influenza viruses e.g., some of them showed good activity against Human Coronavirus 229E. This work could potentially lead to the development of antiviral drugs which possess the crucial structural motifs that are needed for antiviral activity, while missing those which contribute to the antibacterial effect. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral" title="antiviral">antiviral</a>, <a href="https://publications.waset.org/abstracts/search?q=glycopeptide" title=" glycopeptide"> glycopeptide</a>, <a href="https://publications.waset.org/abstracts/search?q=semisynthetic" title=" semisynthetic"> semisynthetic</a>, <a href="https://publications.waset.org/abstracts/search?q=teicoplanin" title=" teicoplanin"> teicoplanin</a> </p> <a href="https://publications.waset.org/abstracts/97121/teicoplanin-derivatives-with-antiviral-activity-synthesis-and-biological-evaluation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97121.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">157</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2075</span> Spatial Relationship of Drug Smuggling Based on Geographic Information System Knowledge Discovery Using Decision Tree Algorithm</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Niamkaeo">S. Niamkaeo</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Robert"> O. Robert</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Chaowalit"> O. Chaowalit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this investigation, we focus on discovering spatial relationship of drug smuggling along the northern border of Thailand. Thailand is no longer a drug production site, but Thailand is still one of the major drug trafficking hubs due to its topographic characteristics facilitating drug smuggling from neighboring countries. Our study areas cover three districts (Mae-jan, Mae-fahluang, and Mae-sai) in Chiangrai city and four districts (Chiangdao, Mae-eye, Chaiprakarn, and Wienghang) in Chiangmai city where drug smuggling of methamphetamine crystal and amphetamine occurs mostly. The data on drug smuggling incidents from 2011 to 2017 was collected from several national and local published news. Geo-spatial drug smuggling database was prepared. Decision tree algorithm was applied in order to discover the spatial relationship of factors related to drug smuggling, which was converted into rules using rule-based system. The factors including land use type, smuggling route, season and distance within 500 meters from check points were found that they were related to drug smuggling in terms of rules-based relationship. It was illustrated that drug smuggling was occurred mostly in forest area in winter. Drug smuggling exhibited was discovered mainly along topographic road where check points were not reachable. This spatial relationship of drug smuggling could support the Thai Office of Narcotics Control Board in surveillance drug smuggling. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=decision%20tree" title="decision tree">decision tree</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20smuggling" title=" drug smuggling"> drug smuggling</a>, <a href="https://publications.waset.org/abstracts/search?q=Geographic%20Information%20System" title=" Geographic Information System"> Geographic Information System</a>, <a href="https://publications.waset.org/abstracts/search?q=GIS%20knowledge%20discovery" title=" GIS knowledge discovery"> GIS knowledge discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=rule-based%20system" title=" rule-based system"> rule-based system</a> </p> <a href="https://publications.waset.org/abstracts/99772/spatial-relationship-of-drug-smuggling-based-on-geographic-information-system-knowledge-discovery-using-decision-tree-algorithm" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99772.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=antiviral%20drug&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=antiviral%20drug&page=3">3</a></li> <li class="page-item"><a class="page-link" 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