CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '921704438896ce71',cH: 'V0SOaj.QVFouE.S35ht83tNL8kFPxfp__8EtLEqqWAQ-1742157112-1.2.1.1-cqeecTr5jiObJAlPA4DYRVVchovOmCaLrY7.AX0SBOlsEGe3J_yaDnZ5DltE6_Nx',cUPMDTk: "\/doi\/10.1021\/ef800189k?__cf_chl_tk=WsaD_OPtu9rkbLVLq3U8OJjIEuTFbsAmy6JRx.QL6lU-1742157112-1.0.1.1-tvh6OLs9FJ8tDbtMmj4CfkEq8iFeiO0XOYZV5kHxoQs",cFPWv: 'g',cITimeS: '1742157112',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/ef800189k?__cf_chl_f_tk=WsaD_OPtu9rkbLVLq3U8OJjIEuTFbsAmy6JRx.QL6lU-1742157112-1.0.1.1-tvh6OLs9FJ8tDbtMmj4CfkEq8iFeiO0XOYZV5kHxoQs",md: ".jcBt0Fy7yOUlyo5eEStM7tBgrXpj7xd1dxpQA4LKKw-1742157112-1.2.1.1-0OkQVv5MIhXQ._UuPz.oI4r1p6heUrAomOyKlw6ZahQgxQV6.7ygMwh6lE5u066EIQFX8zxzGgau7BzJDKfKCmP200jVZerh8ieEKXKHHgngGaL2pV9VqfHikJMBLG7z5ES1m91XDS4.UzCBYDzR3yYFE_r5.6BrVoWEuqqRYlO16IbjfI5jbQJ2z.NJoZa3r9JpcGt4VcBZxmJ7W273AN_28crtXxPWHyg5fdor9_wB7Y0RfPkYpBIXefGAMnyhLhwBv46Co9JRGbRG9lQxgg7fuIW5D77YGBLmRIp4tjmt7hxWTH1jkLM6QIGiCUF.RLbuCp2HwT8bQV7EyM1nuIKV6QGN6uXf1JLKEaNBbkfqDZHJKFWtHs0k3ow7o8rclQPcE1ckfFx6R5fA6X1wXz1B1ZMv.6n2SFjWyeTUp1I9n8vehwyzsNxhAOEc_rqcylQxq_AncvTNFJj3qsUZMHQxQ08k27VZHAtQOdBC3eGm_6KN6FPqoGcSJvGY1qIT7tCsNYlc_nxUAm7mQEsiG4buZqJTO7hYrEO8NNmqJPcagtN0m4iMgyocrTrnGXLVhBwkVgRLWF58PklPQR_FUzL03q9y6TSmWmzg1kWN0dOCuL9xGc_fQHHXA5Eurjq44lWMT4_5Um4dx_77AL8W1l_6WwbuCO7OclE1C3qzUWCu5Zjbg6.bPmWKE7fQws__BItCkd4BtTWraAFW4evvImFZgWElG3wV9Dkqpkeo6feeHplyT1_VxvwUifl5b1YaANfYMih.2SEel5TWkce0whOomUGp8fFvsj0Yn09zDe.Vwln_zfuuu3VTMAo8zXEaLQVfOJ5816Pre_8pPvAwODFojQpZ75ZepLgNmYjW9360CGQXyvT6v8_A7JfSUzFWeZ9d13p.dW8CdBRdYJGtuFCIaaFjEMJnx73guK1ilvLVDCflgKcJ7qxL9YAwyLF00dXAz49vBkOahE_etu30QTiU2ZW_GsrTdKyaUGlp3nvxVZaNEECXKTe4dumGU__GZmMpEYS.JAG2v0RedTt0.umAcIoC1f86Na4P6ixLZafpVT3WpFLBMDZbjF827gsqg6RJwrfEiIvuqgoEW7oPOYsd6q9g19RCJP0bgz8uuHIFWx.WUrxxmw.4fyFmlIq8y9Uw99pg7zVm8cNuowoXXz70gK.BPFDsJvyBNf2bAGTa3TDD_lzmac831I.a40mM20Jr4Y8OHNOq0h1J3XMuGhM4d1GAM1oOQOLaFT5Okc0__MT_5nsOBnxC.AXIafJu",mdrd: "U57NUabNnEpYw8iq_o1NPnUISFo0p6uXq.8Vjs.3hxA-1742157112-1.2.1.1-d2O7RvFkGTsjBbtAEpUv2FTvMHe_6xOsrNdmrlSQemJDL2lhyyes70Lz_UEcPvziXXejRX8LwdinK1TlMpLL2efLqsnjbNvHR862jvstwCPdrobGeZ8UAMZqO_u1jwfs7HrtvHSvfMWcW6kxt4yDp1LkNcIFfDA_KS__mGC1A27AmX81hyfc0wIULHdElHBF7BW8Jo2wQjJRLjG7zaSBV8HLjNJ8RnmDn8HthRZ2hD1I9aFqfWPAOcFpBq8rQH1naJF7EwN8Z.glasn5vwGR3M87b.5UbbkLzJlrN1JCYVQsXOHqlnKmIvKVSrHXcUnonBtrXIcnssl4BgpMLP6nnBVfsrs6Om6U61q7AtWBdzycNi4msYzak8yNLTuVttFVjkDB81MYle0n8RzuQRu4b9DprnDtAqXsJkhuC9ei.w6jGKvXQFG.NN21F4ySLXCec37UNbDpsQ7Z4MupImqN05Qs1JZD_g3gGEeD8iHCuPXG5jVLHEnsKmhtyGT.HOv9wtUZBKJlRW_NE8jSWeQxol_dAtZyVIG09zjECt4JjoPoblWbLQd5TlkYf8NBdSpvVsRCt0rhDo52b2wtqEQ70xA3loqV6_Em9u8ntxm43OEO93_xN99pZdAmG.ZicULqbE9iG2Gus8d_3SQOQqm7ABbyPB56sjd0QnSKQJTh57ZWaLYsnBK4Bc7Va.xNVQUg_zB3WLnVwtmdSw94XOdCfy.hcdm2geN3yab02NMxaNs81iqTPzjDK5UJLYBNrtiEQV1lYJ00v8V6VQWtSXCmaG2lpnZxK_gef0LufgWLQV6aw6ptLnz1P_4Kzdo1WmcNJlX6HFRLmN7OsVSGPw93bKTQwSo_mpy9WR_3adZtB_M23nvRJxaJBLv8e13LKgKQFBAfBwzgwEDaof06JHTxHpZD157lGqL89nEQWOxCd28p_nz_7NLzgiqLUEV9ZBrUsUtl7PMoTeKh_.W8xiBhilI3z9TyQkSFus7hudbxQaqN4.5MtnZYUCC3iu3qZuqItuAoLsJIw04AGxCNMr5alaeUpMmr9gqQGqiYzndwDEL5EOjmOznCYe70IGii0S_NXHvYAjvKQGiRSmx2XbVlvWGkiAFQi3dhU.iJXGpuLorrCfudRy4Yn51jYnLTxR8G5TV_w3d1FGa6_9IdRqTv7nzJjcqIU44iYQBSZ2xXgEcOXGmJIr0f60t0bMRso6PFUhIsSJ51wlfLNL2QHQBfZZSyrSXErlJc9nUYitRi55WDYmk19vFDMF7DXw_K9XGcXVUZk55e.TlKw3K_2RwRBVOUtpzQVZtA_5Yc6TAx1MkFOzB_rb3o2bbUeJwtG4b1nTbDnu.p3ak0C8PDlQxb663LqWc_oCX7m.VTO4V9q4sXH.5xAWHsNpgjG820uiXZH6GfTfQuuL6RVx2NYjKvIY1yeQKtWffj58upuvs84Ddz0ppCemnZszyXMuwAVLGZo3wVTJEAEP4B_QBTVVyAniTZ_obWVNU4drrgo4YRXrI5XYXPz7IYiErg1UdZu01lvVDa7VSJhH9WG1FYPU4OYNP37HJJFlXkOrx9jb4lNHhuI794WOU6C1bKDntq3WEBqW_oWEMP_QLpEY_1LhfgutQX7kLTIXxHBK03LVaPr2RqJ7w4kVnG2YlJ_OR9a9wHPb2etmJRLYHUKseSuwrMd2IIlckE7iTHyAxQsYis7kgoUr4LTXGP3HHnxAWnFQOsQDjPmnAkmzNEsy8rvD2O0wq43H7wIju9iNM0j_yJVpFflyDLbjDNDK2QcrMvPl2OnbHfNFq78_H9n2s5a9iAgIuAu.A1PMb603Pera2cRHKnBxP7UVYL0Ho7uCmFzZU_yzWQXb23aOplEH7KnaMyJS7hSd52rEyPdRFaowpDZIqaBbU.UMf0V5Wmaxl5L0Y5v25t63.xS7oiFBMRlDsKtc9XaHEkChQWsHbXSUMYrwIeHevmd_Vb7ZbFq9r4Hl0tuBXcOs9Tclv0vEVEKfSnmJYwN_sSjV86j3WTiuS_7xO2D1w2qfkUZ8cJYUKTrP45Vr.H4ofSLPL0QFfrf0kTEw"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=921704438896ce71';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/ef800189k?__cf_chl_rt_tk=WsaD_OPtu9rkbLVLq3U8OJjIEuTFbsAmy6JRx.QL6lU-1742157112-1.0.1.1-tvh6OLs9FJ8tDbtMmj4CfkEq8iFeiO0XOYZV5kHxoQs" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>