NICHD Rett syndrome Research Information | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

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Peng Loh Lab</span> </a> </li> <li class="mobile-menu-link"> <a href="/research/atNICHD/Investigators/shi"> <span>Yun-Bo Shi Lab</span> </a> </li> </ul> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ResearchFundedbyNICHD" type="button" > <span>Research Funded by NICHD</span> </button> <ul id="basic-mobile-nav-section-ResearchFundedbyNICHD" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/research/fundedbyNICHD" class="parent-link"> <span>Research Funded by NICHD</span> </a> </li> <li class="mobile-menu-link"> <a href="/derredirect"> <span>Division of Extramural Research (DER)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dea"> <span>Division of Extramural Activities (DEA)</span> </a> </li> <li class="mobile-menu-link"> <a href="/ncmrrredirect"> <span>National Center for Medical Rehabilitation Research (NCMRR)</span> </a> 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aria-controls="basic-mobile-nav-section-CarneyComplex" type="button" > <span>Carney Complex</span> </button> <ul id="basic-mobile-nav-section-CarneyComplex" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/carneycomplex" class="parent-link"> <span>Carney Complex</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/carneycomplex/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/carneycomplex/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/carneycomplex/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/carneycomplex/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CerebralPalsy" type="button" > <span>Cerebral Palsy</span> </button> <ul id="basic-mobile-nav-section-CerebralPalsy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy" class="parent-link"> <span>Cerebral Palsy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CongenitalAdrenalHyperplasia(CAH)" type="button" > <span>Congenital Adrenal Hyperplasia (CAH)</span> </button> <ul id="basic-mobile-nav-section-CongenitalAdrenalHyperplasia(CAH)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/cah" class="parent-link"> <span>Congenital Adrenal Hyperplasia (CAH)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CongenitalAnomalies" type="button" > <span>Congenital Anomalies</span> </button> <ul id="basic-mobile-nav-section-CongenitalAnomalies" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies" class="parent-link"> <span>Congenital Anomalies</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/about"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ContraceptionandBirthControl" type="button" > <span>Contraception and Birth Control</span> </button> <ul id="basic-mobile-nav-section-ContraceptionandBirthControl" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/contraception" class="parent-link"> <span>Contraception and Birth Control</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CushingSyndrome" type="button" > <span>Cushing Syndrome</span> </button> <ul id="basic-mobile-nav-section-CushingSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/cushing" class="parent-link"> <span>Cushing Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Diabetes" type="button" > <span>Diabetes</span> </button> <ul id="basic-mobile-nav-section-Diabetes" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/diabetes" class="parent-link"> <span>Diabetes</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DownSyndrome" type="button" > <span>Down Syndrome</span> </button> <ul id="basic-mobile-nav-section-DownSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/downsyndrome" class="parent-link"> <span>Down Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DrivingRisk" type="button" > <span>Driving Risk</span> </button> <ul id="basic-mobile-nav-section-DrivingRisk" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/drivingrisk" class="parent-link"> <span>Driving Risk</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-EarlyLearning" type="button" > <span>Early Learning</span> </button> <ul id="basic-mobile-nav-section-EarlyLearning" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/early-learning" class="parent-link"> <span>Early Learning</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Endometriosis" type="button" > <span>Endometriosis</span> </button> <ul id="basic-mobile-nav-section-Endometriosis" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/endometriosis" class="parent-link"> <span>Endometriosis</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FragileXSyndrome" type="button" > <span>Fragile X Syndrome</span> </button> <ul id="basic-mobile-nav-section-FragileXSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/fragilex" class="parent-link"> <span>Fragile X Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FragileX-AssociatedPrimaryOvarianInsufficiency(FXPOI)" type="button" > <span>Fragile X-Associated Primary Ovarian Insufficiency (FXPOI)</span> </button> <ul id="basic-mobile-nav-section-FragileX-AssociatedPrimaryOvarianInsufficiency(FXPOI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi" class="parent-link"> <span>Fragile X-Associated Primary Ovarian Insufficiency (FXPOI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FragileX-AssociatedTremorandAtaxiaSyndrome(FXTAS)" type="button" > <span>Fragile X-Associated Tremor and Ataxia Syndrome (FXTAS)</span> </button> <ul id="basic-mobile-nav-section-FragileX-AssociatedTremorandAtaxiaSyndrome(FXTAS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/fxtas" class="parent-link"> <span>Fragile X-Associated Tremor and Ataxia Syndrome (FXTAS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-HIV/AIDS" type="button" > <span>HIV/AIDS</span> </button> <ul id="basic-mobile-nav-section-HIV/AIDS" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/hiv" class="parent-link"> <span>HIV/AIDS</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-High-RiskPregnancy" type="button" > <span>High-Risk Pregnancy</span> </button> <ul id="basic-mobile-nav-section-High-RiskPregnancy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/high-risk" class="parent-link"> <span>High-Risk Pregnancy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Hypoparathyroidism" type="button" > <span>Hypoparathyroidism</span> </button> <ul id="basic-mobile-nav-section-Hypoparathyroidism" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/hypopara" class="parent-link"> <span>Hypoparathyroidism</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/resources/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-InfantCareandInfantHealth" type="button" > <span>Infant Care and Infant Health</span> </button> <ul id="basic-mobile-nav-section-InfantCareandInfantHealth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/infantcare" class="parent-link"> <span>Infant Care and Infant Health</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-InfantMortality" type="button" > <span>Infant Mortality</span> </button> <ul id="basic-mobile-nav-section-InfantMortality" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality" class="parent-link"> <span>Infant Mortality</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/topicinfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-InfertilityandFertility" type="button" > <span>Infertility and Fertility</span> </button> <ul id="basic-mobile-nav-section-InfertilityandFertility" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/infertility" class="parent-link"> <span>Infertility and Fertility</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-IntellectualandDevelopmentalDisabilities(IDDs)" type="button" > <span>Intellectual and Developmental Disabilities (IDDs)</span> </button> <ul id="basic-mobile-nav-section-IntellectualandDevelopmentalDisabilities(IDDs)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/idds" class="parent-link"> <span>Intellectual and Developmental Disabilities (IDDs)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-KlinefelterSyndrome(KS)" type="button" > <span>Klinefelter Syndrome (KS)</span> </button> <ul id="basic-mobile-nav-section-KlinefelterSyndrome(KS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter" class="parent-link"> <span>Klinefelter Syndrome (KS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-LaborandDelivery" type="button" > <span>Labor and Delivery</span> </button> <ul id="basic-mobile-nav-section-LaborandDelivery" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery" class="parent-link"> <span>Labor and Delivery</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/topicinfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-LearningDisabilities" type="button" > <span>Learning Disabilities</span> </button> <ul id="basic-mobile-nav-section-LearningDisabilities" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/learningdisabilities" class="parent-link"> <span>Learning Disabilities</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-MaternalMorbidityandMortality" type="button" > <span>Maternal Morbidity and Mortality</span> </button> <ul id="basic-mobile-nav-section-MaternalMorbidityandMortality" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality" class="parent-link"> <span>Maternal Morbidity and Mortality</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-McCune-AlbrightSyndrome(MAS)" type="button" > <span>McCune-Albright Syndrome (MAS)</span> </button> <ul id="basic-mobile-nav-section-McCune-AlbrightSyndrome(MAS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright" class="parent-link"> <span>McCune-Albright Syndrome (MAS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Men'sReproductiveHealth" type="button" > <span>Men's Reproductive Health</span> </button> <ul id="basic-mobile-nav-section-Men'sReproductiveHealth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/menshealth" class="parent-link"> <span>Men's Reproductive Health</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Menopause" type="button" > <span>Menopause</span> </button> <ul id="basic-mobile-nav-section-Menopause" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/menopause" class="parent-link"> <span>Menopause</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-MenstruationandMenstrualProblems" type="button" > <span>Menstruation and Menstrual Problems</span> </button> <ul id="basic-mobile-nav-section-MenstruationandMenstrualProblems" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/menstruation" class="parent-link"> <span>Menstruation and Menstrual Problems</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-MuscularDystrophy" type="button" > <span>Muscular Dystrophy</span> </button> <ul id="basic-mobile-nav-section-MuscularDystrophy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/musculardys" class="parent-link"> <span>Muscular Dystrophy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-NecrotizingEnterocolitis(NEC)" type="button" > <span>Necrotizing Enterocolitis (NEC)</span> </button> <ul id="basic-mobile-nav-section-NecrotizingEnterocolitis(NEC)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/nec" class="parent-link"> <span>Necrotizing Enterocolitis (NEC)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-NeuralTubeDefects(NTDs)" type="button" > <span>Neural Tube Defects (NTDs)</span> </button> <ul id="basic-mobile-nav-section-NeuralTubeDefects(NTDs)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/ntds" class="parent-link"> <span>Neural Tube Defects (NTDs)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Neuroscience" type="button" > <span>Neuroscience</span> </button> <ul id="basic-mobile-nav-section-Neuroscience" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/neuro" class="parent-link"> <span>Neuroscience</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-NewbornScreening" type="button" > <span>Newborn Screening</span> </button> <ul id="basic-mobile-nav-section-NewbornScreening" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/newborn" class="parent-link"> <span>Newborn Screening</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/conditioninfo/default"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ObesityandOverweight" type="button" > <span>Obesity and Overweight</span> </button> <ul id="basic-mobile-nav-section-ObesityandOverweight" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/obesity" class="parent-link"> <span>Obesity and Overweight</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-OsteogenesisImperfecta(OI)" type="button" > <span>Osteogenesis Imperfecta (OI)</span> </button> <ul id="basic-mobile-nav-section-OsteogenesisImperfecta(OI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp" class="parent-link"> <span>Osteogenesis Imperfecta (OI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PediatricInjury" type="button" > <span>Pediatric Injury</span> </button> <ul id="basic-mobile-nav-section-PediatricInjury" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pediatric" class="parent-link"> <span>Pediatric Injury</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PelvicFloorDisorders" type="button" > <span>Pelvic Floor Disorders</span> </button> <ul id="basic-mobile-nav-section-PelvicFloorDisorders" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor" class="parent-link"> <span>Pelvic Floor Disorders</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PelvicPain" type="button" > <span>Pelvic Pain</span> </button> <ul id="basic-mobile-nav-section-PelvicPain" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain" class="parent-link"> <span>Pelvic Pain</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/clinicaltrials/default"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pharmacology" type="button" > <span>Pharmacology</span> </button> <ul id="basic-mobile-nav-section-Pharmacology" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pharma" class="parent-link"> <span>Pharmacology</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Phenylketonuria(PKU)" type="button" > <span>Phenylketonuria (PKU)</span> </button> <ul id="basic-mobile-nav-section-Phenylketonuria(PKU)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pku" class="parent-link"> <span>Phenylketonuria (PKU)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PheochromocytomaandParaganglioma" type="button" > <span>Pheochromocytoma and Paraganglioma</span> </button> <ul id="basic-mobile-nav-section-PheochromocytomaandParaganglioma" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom" class="parent-link"> <span>Pheochromocytoma and Paraganglioma</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PituitaryTumors" type="button" > <span>Pituitary Tumors</span> </button> <ul id="basic-mobile-nav-section-PituitaryTumors" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors" class="parent-link"> <span>Pituitary Tumors</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PolycysticOvarySyndrome(PCOS)" type="button" > <span>Polycystic Ovary Syndrome (PCOS)</span> </button> <ul id="basic-mobile-nav-section-PolycysticOvarySyndrome(PCOS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pcos" class="parent-link"> <span>Polycystic Ovary Syndrome (PCOS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Prader-WilliSyndrome(PWS)" type="button" > <span>Prader-Willi Syndrome (PWS)</span> </button> <ul id="basic-mobile-nav-section-Prader-WilliSyndrome(PWS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi" class="parent-link"> <span>Prader-Willi Syndrome (PWS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pre-PregnancyCareandPrenatalCare" type="button" > <span>Pre-Pregnancy Care and Prenatal Care</span> </button> <ul id="basic-mobile-nav-section-Pre-PregnancyCareandPrenatalCare" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare" class="parent-link"> <span>Pre-Pregnancy Care and Prenatal Care</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PreeclampsiaandEclampsia" type="button" > <span>Preeclampsia and Eclampsia</span> </button> <ul id="basic-mobile-nav-section-PreeclampsiaandEclampsia" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia" class="parent-link"> <span>Preeclampsia and Eclampsia</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PregnancyLoss" type="button" > <span>Pregnancy Loss</span> </button> <ul id="basic-mobile-nav-section-PregnancyLoss" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss" class="parent-link"> <span>Pregnancy Loss</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pregnancy" type="button" > <span>Pregnancy</span> </button> <ul id="basic-mobile-nav-section-Pregnancy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy" class="parent-link"> <span>Pregnancy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PretermLaborandBirth" type="button" > <span>Preterm Labor and Birth</span> </button> <ul id="basic-mobile-nav-section-PretermLaborandBirth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/preterm" class="parent-link"> <span>Preterm Labor and Birth</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PrimaryOvarianInsufficiency(POI)" type="button" > <span>Primary Ovarian Insufficiency (POI)</span> </button> <ul id="basic-mobile-nav-section-PrimaryOvarianInsufficiency(POI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/poi" class="parent-link"> <span>Primary Ovarian Insufficiency (POI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PubertyandPrecociousPuberty" type="button" > <span>Puberty and Precocious Puberty</span> </button> <ul id="basic-mobile-nav-section-PubertyandPrecociousPuberty" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/puberty" class="parent-link"> <span>Puberty and Precocious Puberty</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ReadingandReadingDisorders" type="button" > <span>Reading and Reading Disorders</span> </button> <ul id="basic-mobile-nav-section-ReadingandReadingDisorders" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/reading" class="parent-link"> <span>Reading and Reading Disorders</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-RehabilitationMedicine" type="button" > <span>Rehabilitation Medicine</span> </button> <ul id="basic-mobile-nav-section-RehabilitationMedicine" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine" class="parent-link"> <span>Rehabilitation Medicine</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-RehabilitativeandAssistiveTechnology" type="button" > <span>Rehabilitative and Assistive Technology</span> </button> <ul id="basic-mobile-nav-section-RehabilitativeandAssistiveTechnology" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech" class="parent-link"> <span>Rehabilitative and Assistive Technology</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/resources"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/health/topics/reproductivehealth"> <span>Reproductive Health</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button usa-current" aria-expanded="true" aria-controls="basic-mobile-nav-section-RettSyndrome" type="button" > <span>Rett Syndrome</span> </button> <ul id="basic-mobile-nav-section-RettSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/rett" class="parent-link"> <span>Rett Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SexuallyTransmittedDiseases(STDs)" type="button" > <span>Sexually Transmitted Diseases (STDs)</span> </button> <ul id="basic-mobile-nav-section-SexuallyTransmittedDiseases(STDs)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/stds" class="parent-link"> <span>Sexually Transmitted Diseases (STDs)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/clinicaltrials/default"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Sleep" type="button" > <span>Sleep</span> </button> <ul id="basic-mobile-nav-section-Sleep" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/sleep" class="parent-link"> <span>Sleep</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SpinaBifida" type="button" > <span>Spina Bifida</span> </button> <ul id="basic-mobile-nav-section-SpinaBifida" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida" class="parent-link"> <span>Spina Bifida</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SpinalCordInjury(SCI)" type="button" > <span>Spinal Cord Injury (SCI)</span> </button> <ul id="basic-mobile-nav-section-SpinalCordInjury(SCI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury" class="parent-link"> <span>Spinal Cord Injury (SCI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Stillbirth" type="button" > <span>Stillbirth</span> </button> <ul id="basic-mobile-nav-section-Stillbirth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth" class="parent-link"> <span>Stillbirth</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/topicinfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Stroke" type="button" > <span>Stroke</span> </button> <ul id="basic-mobile-nav-section-Stroke" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/stroke" class="parent-link"> <span>Stroke</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SuddenInfantDeathSyndrome(SIDS)" type="button" > <span>Sudden Infant Death Syndrome (SIDS)</span> </button> <ul id="basic-mobile-nav-section-SuddenInfantDeathSyndrome(SIDS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/sids" class="parent-link"> <span>Sudden Infant Death Syndrome (SIDS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-TraumaticBrainInjury(TBI)" type="button" > <span>Traumatic Brain Injury (TBI)</span> </button> <ul id="basic-mobile-nav-section-TraumaticBrainInjury(TBI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/tbi" class="parent-link"> <span>Traumatic Brain Injury (TBI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-TurnerSyndrome" type="button" > <span>Turner Syndrome</span> </button> <ul id="basic-mobile-nav-section-TurnerSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/turner" class="parent-link"> <span>Turner Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-UrinaryTractHealth" type="button" > <span>Urinary Tract Health</span> </button> <ul id="basic-mobile-nav-section-UrinaryTractHealth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/urinary" class="parent-link"> <span>Urinary Tract Health</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-UterineFibroids" type="button" > <span>Uterine Fibroids</span> </button> <ul id="basic-mobile-nav-section-UterineFibroids" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/uterine" class="parent-link"> <span>Uterine Fibroids</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Vaginitis" type="button" > <span>Vaginitis</span> </button> <ul id="basic-mobile-nav-section-Vaginitis" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis" class="parent-link"> <span>Vaginitis</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Vasectomy" type="button" > <span>Vasectomy</span> </button> <ul id="basic-mobile-nav-section-Vasectomy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy" class="parent-link"> <span>Vasectomy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Vulvodynia" type="button" > <span>Vulvodynia</span> </button> <ul id="basic-mobile-nav-section-Vulvodynia" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia" class="parent-link"> <span>Vulvodynia</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/health/topics/womenshealth"> <span>Women's Health</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="https://www.nichd.nih.gov/sts"> <span>Safe to Sleep® Campaign</span> </a> </li> <li class="mobile-menu-link"> <a href="https://www.nichd.nih.gov/ncmhep"> <span>National Child and Maternal Health Education Program</span> </a> </li> <li class="mobile-menu-link"> <a href="/publications"> <span>Find Publications</span> </a> </li> <li class="mobile-menu-link"> <a href="/caregivers"> <span>For Caregivers & Providers</span> </a> </li> <li class="mobile-menu-link"> <a href="https://extranet.nichd.nih.gov/nursececourse/Welcome.aspx"> <span>Take Continuing Education</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-Grants&Contracts" > <span>Grants & Contracts</span> </button> <ul id="basic-mobile-nav-section-Grants&Contracts" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts" class="parent-link"> <span>Grants & Contracts</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/research-areas/priorities"> <span>NICHD Research Priorities</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" 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class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/active-nofos-notices" class="parent-link"> <span>Active Funding Opportunities and Notices for NICHD</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/active-nofos-notices/parent"> <span>Parent Announcements (For Unsolicited or Investigator-Initiated Applications)</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/funding-types"> <span>Types of NICHD Funding Mechanisms</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/dissemination"> <span>NICHD Priorities for Dissemination and Implementation Research</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Contracts" type="button" > <span>Contracts</span> </button> <ul 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id="basic-mobile-nav-section-GrantsProcess,Policies&Strategies" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies" class="parent-link"> <span>Grants Process, Policies & Strategies</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-GrantProcess" type="button" > <span>Grant Process</span> </button> <ul id="basic-mobile-nav-section-GrantProcess" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies/process" class="parent-link"> <span>Grant Process</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies/process/overview"> <span>Overview</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies/process/how-to-apply"> <span>How to Apply</span> </a> </li> <li 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href="/grants-contracts/process-strategies/contacts"> <span>NICHD Contacts for Funding Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/peer-review"> <span>Peer Review</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SmallBusinessPrograms" type="button" > <span>Small Business Programs</span> </button> <ul id="basic-mobile-nav-section-SmallBusinessPrograms" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR" class="parent-link"> <span>Small Business Programs</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/about"> <span>About the Programs</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/considerations-contacts-priorities"> <span>NICHD Small Business Programs: Considerations, Contacts, and Priorities</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FundingOpportunities" type="button" > <span>Funding Opportunities</span> </button> <ul id="basic-mobile-nav-section-FundingOpportunities" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/funding" class="parent-link"> <span>Funding Opportunities</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/funding/targeted"> <span>Targeted Opportunities</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/types"> <span>Application Types</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/resources"> <span>Commercialization Resources</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/FAQs"> <span>FAQs</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SmallBusinessSuccessStories" type="button" > <span>Small Business Success Stories</span> </button> <ul id="basic-mobile-nav-section-SmallBusinessSuccessStories" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase" class="parent-link"> <span>Small Business Success Stories</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/BioSensics"> <span>BioSensics™ – Wearable Sensors for Stroke Recovery and Chronic Disability Care</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/SEEKER"> <span>SEEKER® – The First FDA-Authorized Newborn Screening Platform for Lysosomal Storage Disorders</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Simbex-HITS"> <span>Simbex Head Impact Telemetry System – Real-time Monitoring to Improve Safety in Sports</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/SpermCheck"> <span>SpermCheck® – FDA-Cleared Home Test for Male Fertility</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/bili-hut"> <span>bili-hut™ – FDA-Cleared Phototherapy for Treating Newborn Jaundice at Home</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Elagolix"> <span>Elagolix – The First FDA-Approved Treatment for Endometriosis and Uterine Fibroids</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Buzzy"> <span>Buzzy®—Pain Relief for Pediatric Vaccinations</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Miya-Model"> <span>Miya Model™ – Surgical Training Simulator for Obstetrician-Gynecologists (OB/GYNs)</span> </a> </li> </ul> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Training&CareerDevelopment" type="button" > <span>Training & Career Development</span> </button> <ul id="basic-mobile-nav-section-Training&CareerDevelopment" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers" class="parent-link"> <span>Training & Career Development</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SupportforTrainingatUniversitiesandOtherInstitutions" type="button" > <span>Support for Training at Universities and Other Institutions</span> </button> <ul id="basic-mobile-nav-section-SupportforTrainingatUniversitiesandOtherInstitutions" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural" class="parent-link"> <span>Support for Training at Universities and Other Institutions</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/individual"> <span>Individual Research Fellowships (F)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/career"> <span>Career Development (K) Awards</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/institutional"> <span>Institutional Training Grants (T32/K12)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/education"> <span>Education Grants (R25)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/FAQs"> <span>FAQs About Extramural Training</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-TrainingatNICHD" type="button" > <span>Training at NICHD</span> </button> <ul id="basic-mobile-nav-section-TrainingatNICHD" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/intramural" class="parent-link"> <span>Training at NICHD</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/intramural/DIR"> <span>Training in the Division of Intramural Research (DIR)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/intramural/DiPHR"> <span>Training in the Division of Population Health Research (DiPHR)</span> </a> </li> </ul> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/forapplicants"> <span>For Applicants</span> </a> </li> <li class="mobile-menu-link"> <a href="/clinicalresearchpoliciesredirect-grants"> <span>Clinical Research Policies</span> </a> </li> <li class="mobile-menu-link"> <a href="/sampleapplicationsredirect"> <span>Sample Applications</span> </a> </li> <li class="mobile-menu-link"> <a href="/sites/default/files/2017-12/Extramural_Res_Categories_Contacts.pdf"> <span>Find a Program Officer</span> </a> </li> <li class="mobile-menu-link"> <a href="https://grants.nih.gov/grants/forms.htm"> <span>Forms</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-ClinicalResearch" > <span>Clinical Research</span> </button> <ul id="basic-mobile-nav-section-ClinicalResearch" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/clinical-research" class="parent-link"> <span>Clinical Research</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research#whatis"> <span>What Is Clinical Research?</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research#find"> <span>Find NICHD Clinical Trials</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research#clinicalcare"> <span>Where Can I Find Clinical Care Recommendations and Practice Guidelines?</span> </a> </li> <li class="mobile-menu-link"> <a href="/forresearchers"> <span>For Researchers</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pre-ApplicationProcessforNICHDNetworkMultisiteClinicalResearch" type="button" > <span>Pre-Application Process for NICHD Network Multisite Clinical Research</span> </button> <ul id="basic-mobile-nav-section-Pre-ApplicationProcessforNICHDNetworkMultisiteClinicalResearch" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/clinical-research/clinical-trial-preapplication-process" class="parent-link"> <span>Pre-Application Process for NICHD Network Multisite Clinical Research</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/clinical-trial-network-non-NICHD-funding"> <span>Network Projects that Use Non-NICHD Funding</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/clinical-trial-preapplication-process/concept-proposal"> <span>Concept Proposal Info</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/clinicalresearchpoliciesredirect-clinical"> <span>Clinical Research Policies</span> </a> </li> <li class="mobile-menu-link"> <a href="/NICHDpolicies-clinical"> <span>NICHD Policies for Data & Safety Monitoring</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/CSI-curriculum"> <span>Clinician-Scientist Investigator (CSI) Curriculum</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-Newsroom" > <span>Newsroom</span> </button> <ul id="basic-mobile-nav-section-Newsroom" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/newsroom" class="parent-link"> <span>Newsroom</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/news"> <span>News & Updates</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DigitalMedia" type="button" > <span>Digital Media</span> </button> <ul id="basic-mobile-nav-section-DigitalMedia" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/newsroom/digital-media" class="parent-link"> <span>Digital Media</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/infographics"> <span>Infographics</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/videos"> <span>Videos</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/podcastsandaudio"> <span>Podcasts and Audio</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/socialmedia"> <span>Social Media</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/newsroom/NICHDnews/index"> <span>Join NICHD Listservs</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-AboutNICHD" > <span>About NICHD</span> </button> <ul id="basic-mobile-nav-section-AboutNICHD" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about" class="parent-link"> <span>About NICHD</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Organization" type="button" > <span>Organization</span> </button> <ul id="basic-mobile-nav-section-Organization" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org" class="parent-link"> <span>Organization</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-OfficeoftheDirector" type="button" > <span>Office of the Director</span> </button> <ul id="basic-mobile-nav-section-OfficeoftheDirector" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/od" class="parent-link"> <span>Office of the Director</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/directors_corner"> <span>Director's Corner</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/oam"> <span>Office of Administrative Management (OAM)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/oc"> <span>Office of Communications (OC)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/odss"> <span>Office of Data Science and Sharing (ODSS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/ogh"> <span>Office of Global Health (OGH)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/olppe"> <span>Office of Legislation, Public Policy, and Ethics (OLPPE)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/ospra"> <span>Office of Science Policy, Reporting, and Program Analysis (OSPRA)</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DivisionofExtramuralResearch(DER)" type="button" > <span>Division of Extramural Research (DER)</span> </button> <ul id="basic-mobile-nav-section-DivisionofExtramuralResearch(DER)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/der" class="parent-link"> <span>Division of Extramural Research (DER)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/der/branches"> <span>Extramural Scientific Branches</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DivisionofExtramuralActivities(DEA)" type="button" > <span>Division of Extramural Activities (DEA)</span> </button> <ul id="basic-mobile-nav-section-DivisionofExtramuralActivities(DEA)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/dea" class="parent-link"> <span>Division of Extramural Activities (DEA)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dea/gmb"> <span>Grants Management Branch (GMB)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dea/oep"> <span>Office of Extramural Policy (OEP)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dea/srb"> <span>Scientific Review Branch (SRB)</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DivisionofIntramuralResearch(DIR)" type="button" > <span>Division of Intramural Research (DIR)</span> </button> <ul id="basic-mobile-nav-section-DivisionofIntramuralResearch(DIR)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/dir" class="parent-link"> <span>Division of Intramural Research (DIR)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dir/osd"> <span>Office of the Scientific Director (OSD)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dir/dph"> <span>Division of Population Health Research (DiPHR)</span> </a> </li> <li class="mobile-menu-link"> <a href="/research/atNICHD/Investigators"> <span>Principal Investigators</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dir/affinity-groups"> <span>Affinity Groups</span> </a> </li> <li class="mobile-menu-link"> <a 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class="field field--name-title field--type-string field--label-hidden">NICHD Rett syndrome Research Information</span> </h1> </div> <div id="block-mobile-related-external-spn-url" class="block block-ctools-block block-entity-field:node:field-related-external-spn-url related-external-link display-block tablet:display-none mobile-related-external-link"> <div class="button-wrapper usa-button"> <a lang="es" class="button-link" aria-label="Visita esta página en español" href="https://espanol.nichd.nih.gov/salud/temas/rett/investigaciones">En Español</a> <svg class="usa-icon" aria-hidden="true" focusable="false" role="img"> <use xlink:href="/themes/custom/uswds_nichd/assets/img/sprite.svg#arrow_forward"></use> </svg> </div> </div> <div id="block-nichd-content" class="block block-system block-system-main-block"> <article data-history-node-id="2444"> <div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Intellectual and developmental disabilities, including Rett syndrome, are a significant focus of the NICHD’s support for research. NICHD has supported research on Rett syndrome for the past 25 years and continues to do so in the hope of learning how to slow, stop, and ultimately reverse its effects. NICHD supported the researchers who in 1999 discovered that a mutation of the MECP2 gene causes Rett syndrome.</p> <div data-embed-button="nichd_accordion_embed_btn" data-entity-embed-display="view_mode:nichd_accordion.accordion" data-entity-type="nichd_accordion" data-entity-uuid="06970310-45cd-4e01-88cd-e559e812c6a4" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity"> <div class="usa-accordion usa-accordion--multiselectable" data-allow-multiple> <h2 class="usa-accordion__heading"> <button id="goals" class="usa-accordion__button" aria-expanded="false" aria-controls="accordion-id-2246"> <span class="accordion-button-icon"></span> NICHD Research Goals </button> </h2> <div id="accordion-id-2246" class="usa-accordion__content usa-prose"> <div class="clearfix text-formatted field field--name-field-nichd-accordion-body field--type-text-long field--label-hidden field__item"><p>NICHD sponsors research and research training aimed at preventing intellectual and related developmental disabilities and ameliorating their effects. Specific programs support biomedical, biobehavioral, behavioral, and translational research in the etiology and pathophysiology of Rett syndrome and in its screening, prevention, treatment, and epidemiology. The genetics of Rett syndrome is also an important area of NICHD research. In fact, it was Institute-funded scientists who in 1999 found that one cause of this disorder is a mutated <em>MECP2</em> gene.</p> <p>NICHD-supported research into Rett syndrome includes the study of:</p> <ul type="disc"> <li>Its cause</li> <li>The replication, co-regulation, expression, and role of the <em>MECP2</em> gene and other genetic causes of or contributors to Rett syndrome</li> <li>The relationship between genes and physical traits in patients with the syndrome.</li> <li>The role played by glia cells in manufacturing MeCP2 protein</li> <li>Brain features and abnormalities associated with the <em>MECP2</em> gene</li> <li>Commonalities with and differences from classic autism and regressive autism</li> </ul> </div> </div> <h2 class="usa-accordion__heading"> <button id="activities" class="usa-accordion__button" aria-expanded="false" aria-controls="accordion-id-2247"> <span class="accordion-button-icon"></span> Research Activities and Advances </button> </h2> <div id="accordion-id-2247" class="usa-accordion__content usa-prose"> <div class="clearfix text-formatted field field--name-field-nichd-accordion-body field--type-text-long field--label-hidden field__item"><ul type="disc"> <li><a href="#institute">Institute Activities and Advances</a></li> <li><a href="#other">Other Activities and Advances</a></li> </ul> <h3><a name="institute"></a>Institute Activities and Advances</h3> <p>In 1999, NICHD-supported scientists<sup><a href="#f1">1</a></sup> discovered that most girls with Rett syndrome had a change in the pattern of a single gene—the Methylcytosine-binding protein 2 (<em>MECP2</em>) gene on the X chromosome. Research shows that between 90% and 95% of girls with Rett syndrome have a mutation in this gene.<sup><a href="#f2">2</a>,<a href="#f3">3</a></sup> This gene makes Methylcytosine-binding protein 2 (MeCP2), which is necessary for the development of the nervous system, especially the brain. The mutation causes the gene to make less than the needed amounts of the protein, or to make a damaged protein that the body can't use. As a result, there may not be enough usable protein for the brain to develop normally.</p> <p>Researchers are still trying to understand exactly how the brain uses MeCP2 and how problems with the protein cause the typical features of Rett syndrome. Normally, MeCP2 helps to "turn off" certain genes that make different proteins in nerve cells and other cells. Without MeCP2, the body keeps making these products, even when it no longer needs them. After a while, having high amounts of these products in the body may actually start to damage the nervous system and cause the problems of Rett syndrome.</p> <p>Boys with <a href="/health/topics/klinefelter">Klinefelter syndrome</a> can exhibit the classic Rett phenotype. However, some familial cases of Rett syndrome have been found in which male siblings were born with severe encephalopathy and died by one to two years of age. Genetic analyses showed the same <em>MECP2</em> mutations as in their sisters with Rett syndrome, leading to the suggestion that Rett syndrome is actually a milder manifestation of these mutations and that boys with no wild-type <em>MECP2</em> exhibit a more severe phenotype.<sup><a href="#f4">4</a></sup></p> <p>In 2002, scientists funded by NICHD developed a new mouse model for Rett syndrome. This mouse model more closely mimicked the symptoms of Rett syndrome found in humans than did earlier mouse models. For more on the development of this mouse model, visit the NICHD news release at: <a href="/newsroom/releases/rett_syndrome">https://www.nichd.nih.gov//newsroom/releases/rett_syndrome</a></p> <p>Until 2008, researchers did not know the extent to which <em>MECP2</em> controlled multiple functions in the brain. That is when NICHD-supported researchers discovered the gene's numerous roles not only as a repressor but also as an activator of thousands of other genes to maintain proper brain functions. For more on this research, see <a href="/newsroom/releases/may302008_rett_syndrome_gene">NIH Researchers Find That Rett Syndrome Gene is Full of Surprises</a>.</p> <p>Much of NICHD's research on Rett syndrome is supported through its <a href="/about/org/der/branches/iddb">Intellectual and Developmental Disabilities Branch (IDDB)</a>. The NICHD has provided grants for research in the following areas:</p> <ul type="disc"> <li><strong>Role of MeCP2 in Rett syndrome</strong>. A 10-year study is examining the regulation and activity of the MeCP2 protein in cells. Researchers want to determine how these cells are affected by the protein's mutation. The study's long-term goals are to (a) understand why the nervous system functions improperly in patients with Rett syndrome, and (b) determine ways that the nervous system can be regulated to improve patients' intellectual and physical function.<sup><a href="#f5">5</a></sup></li> <li><strong>Glia cells and Rett syndrome</strong>. Glia cells insulate nerves so that they can perform well. Because glia cells use MeCP2 protein to make the insulation (myelin), mutated MeCP2 protein results in poor insulation. One study showed that the addition of new glia cells that make normal MeCP2 protein can stop the symptoms of Rett syndrome in mice.<sup><a href="#f6">6</a></sup> Another study found that locomotion and anxiety levels are improved in mutant mice when their glia cells resume manufacture of the MeCP2 protein.<sup><a href="#f6">6</a></sup></li> <li><strong>Expression of MeCP2 protein</strong>. Researchers have determined that some patients with autism spectrum disorders may have a genetic defect that reduces their brain's expression of MeCP2 protein.<sup><a href="#f7">7</a></sup></li> <li><strong>Co-regulation of the <em>MECP2</em> gene</strong>. The <em>MECP2</em> gene and the early growth response gene 2 influence each other while the brain develops. Scientists have confirmed that the interaction of these genes is important in people with Rett syndrome and autism.<sup><a href="#f8">8</a></sup></li> </ul> <h3><a name="other"></a>Other Activities and Advances</h3> <ul type="disc"> <li>Through its IDDB, NICHD co-funds the <a href="https://www.rarediseasesnetwork.org/research-groups" target="_blank">Rett and MeCP2-Related Disorders Consortium</a> <a aria-label="(Link is external)" href="/external-disclaimer" tabindex="0" target="_blank" title="(Link is external)"><img alt="external link" class="data-external" src="/themes/custom/nichd/images/externallink.svg"></a>, which studies three distinct disorders: <a href="/health/topics/rett">Rett syndrome</a> (RTT), <em>MECP2</em> duplication disorder, and RTT-related disorders that are caused by <em>CDKL5</em> and <em>FOXG1</em> mutations and have similar phenotypes to RTT. This Consortium is part of the NIH <a href="https://www.rarediseasesnetwork.org/" target="_blank">Rare Diseases Clinical Research Network</a> <a aria-label="(Link is external)" href="/external-disclaimer" tabindex="0" target="_blank" title="(Link is external)"><img alt="external link" class="data-external" src="/themes/custom/nichd/images/externallink.svg"></a>, teams of doctors, nurses, research coordinators, and research labs throughout the United States working together to improve the lives of people with rare diseases through research.</li> <li>NICHD also supports the International Rett Syndrome Foundation's effort, known as the North American Database<sup><a href="#f10">10</a></sup>, a registry of sorts for people with Rett syndrome This comprehensive project, the first of its kind in North America, includes information on 1,928 participants from the United States and Canada who either have Rett syndrome (85.5% typical, 13.4% atypical) or another diagnosis in conjunction with an <em>MECP2</em> mutation (1.1%). The Database organizes the information by diagnosis, mutation status, and mutation type and frequency. This database provides a unique resource for expanding our understanding of Rett syndrome, for comparison with other national databases, and for future study, including organization of clinical trials based on the expected emergence of fundamental therapies.</li> <li>NICHD, the National Institute of Neurological Disorders and Stroke, and private United States organizations supporting Rett syndrome research (the International Rett Syndrome Foundation [IRSF] and the Rett Syndrome Research Trust [RSRT]) held a workshop titled "Setting Priorities for Therapy Development in Rett Syndrome" on September 25–27, 2011, to discuss how to optimize the predictive value of animal models in preclinical research on Rett syndrome. In addition to these funding agencies and foundations, workshop participants included members of the Rett syndrome research community and the pharmaceutical industry, clinicians, and representatives from the U.S. Food and Drug Administration. The workshop's proceedings are detailed in the paper "Preclinical research in Rett syndrome: Setting the foundation for translational success," published in <em>Disease Models & Mechanisms</em> (<a href="https://pubmed.ncbi.nlm.nih.gov/23115203/" target="_blank">PMID: 23115203</a>).</li> </ul> </div> </div> </div> </div> <div data-embed-button="nichd_citations_embed_btn" data-entity-embed-display="view_mode:nichd_citations.citations" data-entity-type="nichd_citations" data-entity-uuid="dc26e2de-66c3-4a95-b591-3a38bdb44934" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity"> <div class="nichd_citations usa-accordion margin-top-2"> <h2> Citations </h2> <button class="usa-accordion__button citationsanchor" aria-expanded="true" aria-controls="citation-id-345" aria-label="Toggle citations open and closed"> </button> <div id="citation-id-345" class="usa-accordion__content usa-prose citations"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><ol> <li><a name="f1"></a> <span>Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2. </span> <em>Nature Genetics</em><span>, 23(2), 185–188. </span></li> <li><a name="f2"></a>Schollen, E., Smeets, E., Deflem, E., Fryns, J. P., & Mathis, G. (2003). Gross rearrangements in the MECP2 gene in three patients with Rett syndrome: Implications for routine diagnosis of Rett syndrome. <em>Human Mutations</em>, 22, 116–120.</li> <li><a name="f3"></a>Zoghbi, H. Y. (2005). MeCP2 dysfunction in humans and mice. Journal of Child Neurology, 20, 736–740.</li> <li><a name="f4"></a>Neul, J. L., & Zoghbi, H. Y. (2004). Rett syndrome: A prototypical neurodevelopmental disorder. <em>Neuroscientist</em>, 10, 118–128.</li> <li><a name="f5"></a>Schanen, N. C. (2012). <em>Investigation of MECP2 function in Rett syndrome, NIH grant project</em>. Retrieved May 10, 2012, from <a href="https://reporter.nih.gov/project-details/7884501" target="_blank">https://reporter.nih.gov/project-details/7884501</a></li> <li><a name="f6"></a>Derecki, N. C., Cronk, J. C., Lu, Z., Xu, E., Abbott, S. B.,Guyenet, P. G., et al. (2012). Wild-type microglia arrest pathology in a mouse model of Rett syndrome. <em>Nature</em>, 484, 105–109.</li> <li><a name="f7"></a>Lioy, D. T., Garg, S. K., Monaghan, C. E., Raber, J., Foust,K. D., Kaspar, B. K., et al. (2011). A role for glia in the progression of Rett's syndrome. <em>Nature</em>, 475, 497–500.</li> <li><a name="f8"></a>Nagarajan, R. P., Hogart, A. R., Gwye, Y., Martin, M. R., & LaSalle, J. M. (2006). Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant <em>MECP2</em> promoter methylation. <em>Epigenetics</em>, 1(4), e1–11.</li> <li><a name="f9"></a>Rare Diseases Clinical Research Network. (2012).<em> Angelman, Rett, and Prader-Willi Syndromes Consortium</em>. Retrieved June 23, 2012, from: <a href="https://www1.rarediseasesnetwork.org/cms/rett/About-Us" target="_blank">https://www1.rarediseasesnetwork.org/cms/rett/About-Us</a> <a href="/external-disclaimer" target="_blank" tabindex="0" title="(Link is external)" aria-label="(Link is external)"><img src="/themes/custom/nichd/images/externallink.svg" alt="external link" class="data-external"></a></li> <li><a name="f10"></a>Percy, A. K., Lane, J. B., Childers, J., Skinner, S., Annese, F., Barrish, J., et al. (2007). Rett syndrome: North American database. <em>Journal of Child Neurology</em>, Dec;22(12), 1338–41.</li> </ol> </div> </div> </div> </div> </div> </div> </article> </div> </div>  <div class="usa-footer__return-to-top"> <a href="#" class="back-to-top-text"> <img class="bttarrow-icon" src="/themes/custom/uswds_nichd/img/backtotop.svg" alt="top of page"> BACK TO TOP </a> </div> </div> <aside aria-label="sidebar-second" class="tablet:grid-col-4 sidebar-second padding-top-2"> <div class="region region-sidebar-second"> <div id="block-related-external-spn-url" class="block block-ctools-block block-entity-field:node:field-related-external-spn-url display-none tablet:display-block related-external-link"> <div class="button-wrapper usa-button"> <a lang="es" class="button-link" aria-label="Visita esta página en español" href="https://espanol.nichd.nih.gov/salud/temas/rett/investigaciones">En Español</a> <svg class="usa-icon" aria-hidden="true" focusable="false" role="img"> <use 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