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href="https://www.academia.edu/109733222/Liposomal_Formulations_in_Clinical_Use_An_Updated_Review"><img alt="Research paper thumbnail of Liposomal Formulations in Clinical Use: An Updated Review" class="work-thumbnail" src="https://attachments.academia-assets.com/107769954/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109733222/Liposomal_Formulations_in_Clinical_Use_An_Updated_Review">Liposomal Formulations in Clinical Use: An Updated Review</a></div><div class="wp-workCard_item"><span>Pharmaceutics</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6fd614bf5cfbb38fe47930bae1f8e997" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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Solid lipid nanoparticles (SLN) easily diffuse the blood-brain barrier (BBB) due to their lipophilic nature. Furthermore, ligand conjugation on SLN surface enhances the targeting efficiency. Lactoferin (Lf) conjugated SLN system is first time attempted for effective brain targeting in this study. Preparation of Lf-modified docetaxel (DTX)-loaded SLN for proficient delivery of DTX to brain. DTX-loaded SLN were prepared using emulsification and solvent evaporation method and conjugation of Lf on SLN surface (C-SLN) was attained through carbodiimide chemistry. These lipidic nanoparticles were evaluated by DLS, AFM, FTIR, XRD techniques and in vitro release studies. Colloidal stability study was performed in biologically simulated environment (normal saline and serum). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470788"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470788/p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation"><img alt="Research paper thumbnail of p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470788/p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation">p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation</a></div><div class="wp-workCard_item"><span>Journal of Nanoparticle Research</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1HNMR and FTIR spectroscopy. In vitro release of drug from DTX loaded pHBA conjugated dendrimer (CDN) was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere®). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470788"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470788"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470788; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470788]").text(description); $(".js-view-count[data-work-id=22470788]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470788; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470788']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470788, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22470788]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470788,"title":"p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation","translated_title":"","metadata":{"abstract":"ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1HNMR and FTIR spectroscopy. In vitro release of drug from DTX loaded pHBA conjugated dendrimer (CDN) was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere®). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Journal of Nanoparticle Research"},"translated_abstract":"ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1HNMR and FTIR spectroscopy. In vitro release of drug from DTX loaded pHBA conjugated dendrimer (CDN) was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere®). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.","internal_url":"https://www.academia.edu/22470788/p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation","translated_internal_url":"","created_at":"2016-02-26T03:22:45.828-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[],"research_interests":[{"id":56,"name":"Materials Engineering","url":"https://www.academia.edu/Documents/in/Materials_Engineering"},{"id":8950,"name":"Nanoparticle","url":"https://www.academia.edu/Documents/in/Nanoparticle"},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles"},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology"},{"id":26694,"name":"Dendrimers","url":"https://www.academia.edu/Documents/in/Dendrimers"},{"id":429224,"name":"Sigma receptor","url":"https://www.academia.edu/Documents/in/Sigma_receptor"},{"id":1524090,"name":"Benzamides","url":"https://www.academia.edu/Documents/in/Benzamides"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470787"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470787/Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment"><img alt="Research paper thumbnail of Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470787/Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment">Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment</a></div><div class="wp-workCard_item"><span>Drug Delivery</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when usin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate property leads to poor oral bioavailability and efficacy. The objective of this study is to formulate and evaluate nanoparticles of RPM, along with a chemosensitizer (piperine, PIP) for improved oral bioavailability and efficacy. Poly(d,l-lactide-co-glycolide) (PLGA) was selected as polymer as it has moderate MDR reversal activity, which may provide additional benefits. The nanoprecipitation method was used to prepare PLGA nanoparticles with particle size below 150 nm, loaded with both drugs (RPM and PIP). Prepared nanoparticles showed sustained in vitro drug release for weeks, with initial release kinetics of zero order with non-Fickian transport, subsequently followed by Higuchi kinetics with Fickian diffusion. An everted gut sac method was used to study the effect of P-gp efflux on drug transport. This reveals that the uptake of the RPM (P-gp substrate) has been increased in the presence of chemosensitizer. Pharmacokinetic studies showed better absorption profile of RPM from polymeric nanoparticles compared to its suspension counterpart and improved bioavailability of 4.8-folds in combination with a chemosensitizer. An in vitro cell line study indicates higher efficacy of nanoparticles compared to free drug solution. Results suggest that the use of a combination of PIP with RPM nanoparticles would be a promising approach in the treatment of breast cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470787"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470787"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470787; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470787]").text(description); $(".js-view-count[data-work-id=22470787]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470787; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470787']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470787, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22470787]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470787,"title":"Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment","translated_title":"","metadata":{"abstract":"P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate property leads to poor oral bioavailability and efficacy. The objective of this study is to formulate and evaluate nanoparticles of RPM, along with a chemosensitizer (piperine, PIP) for improved oral bioavailability and efficacy. Poly(d,l-lactide-co-glycolide) (PLGA) was selected as polymer as it has moderate MDR reversal activity, which may provide additional benefits. The nanoprecipitation method was used to prepare PLGA nanoparticles with particle size below 150 nm, loaded with both drugs (RPM and PIP). Prepared nanoparticles showed sustained in vitro drug release for weeks, with initial release kinetics of zero order with non-Fickian transport, subsequently followed by Higuchi kinetics with Fickian diffusion. An everted gut sac method was used to study the effect of P-gp efflux on drug transport. This reveals that the uptake of the RPM (P-gp substrate) has been increased in the presence of chemosensitizer. Pharmacokinetic studies showed better absorption profile of RPM from polymeric nanoparticles compared to its suspension counterpart and improved bioavailability of 4.8-folds in combination with a chemosensitizer. An in vitro cell line study indicates higher efficacy of nanoparticles compared to free drug solution. Results suggest that the use of a combination of PIP with RPM nanoparticles would be a promising approach in the treatment of breast cancer.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Drug Delivery"},"translated_abstract":"P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate property leads to poor oral bioavailability and efficacy. The objective of this study is to formulate and evaluate nanoparticles of RPM, along with a chemosensitizer (piperine, PIP) for improved oral bioavailability and efficacy. Poly(d,l-lactide-co-glycolide) (PLGA) was selected as polymer as it has moderate MDR reversal activity, which may provide additional benefits. The nanoprecipitation method was used to prepare PLGA nanoparticles with particle size below 150 nm, loaded with both drugs (RPM and PIP). Prepared nanoparticles showed sustained in vitro drug release for weeks, with initial release kinetics of zero order with non-Fickian transport, subsequently followed by Higuchi kinetics with Fickian diffusion. An everted gut sac method was used to study the effect of P-gp efflux on drug transport. This reveals that the uptake of the RPM (P-gp substrate) has been increased in the presence of chemosensitizer. Pharmacokinetic studies showed better absorption profile of RPM from polymeric nanoparticles compared to its suspension counterpart and improved bioavailability of 4.8-folds in combination with a chemosensitizer. An in vitro cell line study indicates higher efficacy of nanoparticles compared to free drug solution. Results suggest that the use of a combination of PIP with RPM nanoparticles would be a promising approach in the treatment of breast cancer.","internal_url":"https://www.academia.edu/22470787/Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment","translated_internal_url":"","created_at":"2016-02-26T03:22:45.653-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470786"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470786/Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials"><img alt="Research paper thumbnail of Alternative Antimicrobial Approach: Nano-Antimicrobial Materials" class="work-thumbnail" src="https://attachments.academia-assets.com/43091600/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470786/Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials">Alternative Antimicrobial Approach: Nano-Antimicrobial Materials</a></div><div class="wp-workCard_item"><span>Evidence-Based Complementary and Alternative Medicine</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6345e5fe6b0964c71e41f88b21e2ad65" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091600,"asset_id":22470786,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091600/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470786"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470786"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470786; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470786]").text(description); $(".js-view-count[data-work-id=22470786]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470786; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470786']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470786, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6345e5fe6b0964c71e41f88b21e2ad65" } } $('.js-work-strip[data-work-id=22470786]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470786,"title":"Alternative Antimicrobial Approach: Nano-Antimicrobial Materials","translated_title":"","metadata":{"grobid_abstract":"Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Evidence-Based Complementary and Alternative Medicine","grobid_abstract_attachment_id":43091600},"translated_abstract":null,"internal_url":"https://www.academia.edu/22470786/Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials","translated_internal_url":"","created_at":"2016-02-26T03:22:45.450-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":43091600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091600/thumbnails/1.jpg","file_name":"246012.pdf","download_url":"https://www.academia.edu/attachments/43091600/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alternative_Antimicrobial_Approach_Nano.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091600/246012-libre.pdf?1456486242=\u0026response-content-disposition=attachment%3B+filename%3DAlternative_Antimicrobial_Approach_Nano.pdf\u0026Expires=1732504539\u0026Signature=QURYXlpFYWDt1y4AReb3vgR8eZW36unhuK7EaiJ5DcKvs5gY4sl-27osRa9PrsEDL3Pq3qIWFgDEFKlNLJ1E-wuU~qRyri5NUEr1zgrZ3sRfhzkjB6syn3Hl0DXfhiKZtZJpdkARioT65NG0GRqt-N6AZsgRFB3oxLl16BwvXrcfa4-Y9dwx4cWA1~wH-iwldeX1KFLCMirITnbFfVl~L6fgQ4K8rAd0saMr-rSRBHBKj07Zw2y~w0K857fDiZgQP4GsRPU1Gd5dEVL~K5xjrJMt5-~uughpWTxfyzRujrc5XhtQGOvzuDyZHAHHQy1OOdbbNrsz7YBO0JkmoQogQA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[{"id":43091600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091600/thumbnails/1.jpg","file_name":"246012.pdf","download_url":"https://www.academia.edu/attachments/43091600/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alternative_Antimicrobial_Approach_Nano.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091600/246012-libre.pdf?1456486242=\u0026response-content-disposition=attachment%3B+filename%3DAlternative_Antimicrobial_Approach_Nano.pdf\u0026Expires=1732504539\u0026Signature=QURYXlpFYWDt1y4AReb3vgR8eZW36unhuK7EaiJ5DcKvs5gY4sl-27osRa9PrsEDL3Pq3qIWFgDEFKlNLJ1E-wuU~qRyri5NUEr1zgrZ3sRfhzkjB6syn3Hl0DXfhiKZtZJpdkARioT65NG0GRqt-N6AZsgRFB3oxLl16BwvXrcfa4-Y9dwx4cWA1~wH-iwldeX1KFLCMirITnbFfVl~L6fgQ4K8rAd0saMr-rSRBHBKj07Zw2y~w0K857fDiZgQP4GsRPU1Gd5dEVL~K5xjrJMt5-~uughpWTxfyzRujrc5XhtQGOvzuDyZHAHHQy1OOdbbNrsz7YBO0JkmoQogQA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470785"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470785/Adenosine_conjugated_lipidic_nanoparticles_for_enhanced_tumor_targeting"><img alt="Research paper thumbnail of Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting" class="work-thumbnail" src="https://attachments.academia-assets.com/43091611/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470785/Adenosine_conjugated_lipidic_nanoparticles_for_enhanced_tumor_targeting">Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting</a></div><div class="wp-workCard_item"><span>International journal of pharmaceutics</span><span>, Jan 31, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonsp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs. The present study was performed to investigate the efficiency of adenosine (ADN) to target solid lipid nanoparticles (SLN) to over expressing adenosine receptor cell lines such as human breast cancer and prostate cancer (MCF-7 and DU-145 cells), respectively. SLN were prepared by emulsification and solvent evaporation process using docetaxel (DTX) as drug and were characterized by various techniques like dynamic light scattering, differential scanning calorimeter and transmission electron microscopy. DTX loaded SLNs were surface modified with ADN, an adenosine receptors ligand using carbodiimide coupling. Conjugation was confirmed using infrared spectroscopy and quantified using ph...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6676bc1eb572cfa85c5b7d0d963a67f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091611,"asset_id":22470785,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091611/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470785"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470785"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470785; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470785]").text(description); $(".js-view-count[data-work-id=22470785]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470785; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470785']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470785, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6676bc1eb572cfa85c5b7d0d963a67f3" } } $('.js-work-strip[data-work-id=22470785]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470785,"title":"Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting","translated_title":"","metadata":{"abstract":"Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs. The present study was performed to investigate the efficiency of adenosine (ADN) to target solid lipid nanoparticles (SLN) to over expressing adenosine receptor cell lines such as human breast cancer and prostate cancer (MCF-7 and DU-145 cells), respectively. SLN were prepared by emulsification and solvent evaporation process using docetaxel (DTX) as drug and were characterized by various techniques like dynamic light scattering, differential scanning calorimeter and transmission electron microscopy. DTX loaded SLNs were surface modified with ADN, an adenosine receptors ligand using carbodiimide coupling. Conjugation was confirmed using infrared spectroscopy and quantified using ph...","publication_date":{"day":31,"month":1,"year":2015,"errors":{}},"publication_name":"International journal of pharmaceutics"},"translated_abstract":"Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs. The present study was performed to investigate the efficiency of adenosine (ADN) to target solid lipid nanoparticles (SLN) to over expressing adenosine receptor cell lines such as human breast cancer and prostate cancer (MCF-7 and DU-145 cells), respectively. SLN were prepared by emulsification and solvent evaporation process using docetaxel (DTX) as drug and were characterized by various techniques like dynamic light scattering, differential scanning calorimeter and transmission electron microscopy. DTX loaded SLNs were surface modified with ADN, an adenosine receptors ligand using carbodiimide coupling. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470784"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470784/p_Aminophenyl_%CE%B1_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain"><img alt="Research paper thumbnail of p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain" class="work-thumbnail" src="https://attachments.academia-assets.com/43091605/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470784/p_Aminophenyl_%CE%B1_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain">p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain</a></div><div class="wp-workCard_item"><span>Chemistry and physics of lipids</span><span>, Jan 25, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metab...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metabolic substrates like carbohydrates and amino acids are able to traverse the blood-brain barrier (BBB) by specific carrier-mediated transport systems like glucose transporters present on the both luminal and abluminal side of the BBB. With this objective, the docetaxel (DTX) loaded solid lipidic nanoparticles were formulated and surface modified with a mannose derived ligand p-aminophenyl-α-d-mannopyranoside (MAN) to develop MAN conjugated lipidic nanoparticles for targeting DTX to brain. Lipidic nanoparticles were prepared using emulsification and solvent evaporation method using stearic acid as charge modifying lipid and conjugated with MAN using carbodimide coupling. These lipidic nanoparticles were successfully characterized using various techniques like DLS, TEM, DSC and FTIR spectroscopy. Cytotoxicity and cell uptake unveiled enhanced efficacy of conjugated lipidic nanoparticles. Ph...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c4a899e5b6bb4287954c4a671389987c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091605,"asset_id":22470784,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091605/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470784"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470784"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470784; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470784]").text(description); $(".js-view-count[data-work-id=22470784]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470784; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470784']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470784, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c4a899e5b6bb4287954c4a671389987c" } } $('.js-work-strip[data-work-id=22470784]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470784,"title":"p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain","translated_title":"","metadata":{"abstract":"Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metabolic substrates like carbohydrates and amino acids are able to traverse the blood-brain barrier (BBB) by specific carrier-mediated transport systems like glucose transporters present on the both luminal and abluminal side of the BBB. With this objective, the docetaxel (DTX) loaded solid lipidic nanoparticles were formulated and surface modified with a mannose derived ligand p-aminophenyl-α-d-mannopyranoside (MAN) to develop MAN conjugated lipidic nanoparticles for targeting DTX to brain. Lipidic nanoparticles were prepared using emulsification and solvent evaporation method using stearic acid as charge modifying lipid and conjugated with MAN using carbodimide coupling. These lipidic nanoparticles were successfully characterized using various techniques like DLS, TEM, DSC and FTIR spectroscopy. Cytotoxicity and cell uptake unveiled enhanced efficacy of conjugated lipidic nanoparticles. Ph...","publication_date":{"day":25,"month":1,"year":2015,"errors":{}},"publication_name":"Chemistry and physics of lipids"},"translated_abstract":"Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metabolic substrates like carbohydrates and amino acids are able to traverse the blood-brain barrier (BBB) by specific carrier-mediated transport systems like glucose transporters present on the both luminal and abluminal side of the BBB. With this objective, the docetaxel (DTX) loaded solid lipidic nanoparticles were formulated and surface modified with a mannose derived ligand p-aminophenyl-α-d-mannopyranoside (MAN) to develop MAN conjugated lipidic nanoparticles for targeting DTX to brain. Lipidic nanoparticles were prepared using emulsification and solvent evaporation method using stearic acid as charge modifying lipid and conjugated with MAN using carbodimide coupling. These lipidic nanoparticles were successfully characterized using various techniques like DLS, TEM, DSC and FTIR spectroscopy. Cytotoxicity and cell uptake unveiled enhanced efficacy of conjugated lipidic nanoparticles. Ph...","internal_url":"https://www.academia.edu/22470784/p_Aminophenyl_%CE%B1_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain","translated_internal_url":"","created_at":"2016-02-26T03:22:45.065-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":43091605,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091605/thumbnails/1.jpg","file_name":"p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm.pdf","download_url":"https://www.academia.edu/attachments/43091605/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"p_Aminophenyl__d_mannopyranoside_engine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091605/p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm-libre.pdf?1456486248=\u0026response-content-disposition=attachment%3B+filename%3Dp_Aminophenyl__d_mannopyranoside_engine.pdf\u0026Expires=1732504540\u0026Signature=JPW1dQRmsg2cwUtR08c9TgO6D5a7PczwCIjJ9fGtO9F~lT03h6n4TuMfnM3nWt1966HusFFwwRNyZZ355Vuyp8ZMKikHKdgol8iyn~gD3vvM2T6~V3C626wrYLRLR6NqWrlSBwrkZs6QJcjTAi3qqkCTZxTLajnTKblnHpK6q1gnJ3rX88XAzRNr9fINDU5rptXgeV5nQRFV3IYUEwXQJWgYh~q3-tq79QTe1eq0FTz9cQe10X29NWD-SRehbQttOo1txOxu2SkrbV8PwqvH5SbV5Q08TM7pcn99A8lxL0hJ-EwiIu7uLWvTHHthlIHTcceuKxL07sBS3WVV2ecg2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"p_Aminophenyl_α_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[{"id":43091605,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091605/thumbnails/1.jpg","file_name":"p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm.pdf","download_url":"https://www.academia.edu/attachments/43091605/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"p_Aminophenyl__d_mannopyranoside_engine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091605/p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm-libre.pdf?1456486248=\u0026response-content-disposition=attachment%3B+filename%3Dp_Aminophenyl__d_mannopyranoside_engine.pdf\u0026Expires=1732504540\u0026Signature=JPW1dQRmsg2cwUtR08c9TgO6D5a7PczwCIjJ9fGtO9F~lT03h6n4TuMfnM3nWt1966HusFFwwRNyZZ355Vuyp8ZMKikHKdgol8iyn~gD3vvM2T6~V3C626wrYLRLR6NqWrlSBwrkZs6QJcjTAi3qqkCTZxTLajnTKblnHpK6q1gnJ3rX88XAzRNr9fINDU5rptXgeV5nQRFV3IYUEwXQJWgYh~q3-tq79QTe1eq0FTz9cQe10X29NWD-SRehbQttOo1txOxu2SkrbV8PwqvH5SbV5Q08TM7pcn99A8lxL0hJ-EwiIu7uLWvTHHthlIHTcceuKxL07sBS3WVV2ecg2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470783"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470783/Cyclosporin_nanosphere_formulation_for_ophthalmic_administration"><img alt="Research paper thumbnail of Cyclosporin nanosphere formulation for ophthalmic administration" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470783/Cyclosporin_nanosphere_formulation_for_ophthalmic_administration">Cyclosporin nanosphere formulation for ophthalmic administration</a></div><div class="wp-workCard_item"><span>International journal of pharmaceutics</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye diseas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye disease, and is available commercially as ophthalmic emulsion formulation (RESTASIS(®)). For increasing efficacy, and for reducing local toxicity including irritation to eyes, CsA nanosphere (CsA-NS) formulation was prepared and evaluated, in this work. CsA-NS formulation was prepared in a pre-concentrate form, which is a homogeneous solution of a CsA in a mixture of surfactants, lipids and solvents and provides nanosphere dispersion when added to aqueous medium. CsA-NS formulation was characterized and adjusted for particle size, pH, and osmolarity, suitable for ophthalmic administration. Thereafter, CsA-NS formulation was evaluated for parameters like irritation to eyes and penetrability of CsA in the rabbit eyes. Results obtained demonstrated that proposed CsA-NS formulation causes less irritation in rabbit eyes, with nearly same CsA penetration in the rabbit eyes in comparison to marketed ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470783"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470783"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470783; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470783]").text(description); $(".js-view-count[data-work-id=22470783]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470783; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470783']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470783, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22470783]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470783,"title":"Cyclosporin nanosphere formulation for ophthalmic administration","translated_title":"","metadata":{"abstract":"Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye disease, and is available commercially as ophthalmic emulsion formulation (RESTASIS(®)). For increasing efficacy, and for reducing local toxicity including irritation to eyes, CsA nanosphere (CsA-NS) formulation was prepared and evaluated, in this work. CsA-NS formulation was prepared in a pre-concentrate form, which is a homogeneous solution of a CsA in a mixture of surfactants, lipids and solvents and provides nanosphere dispersion when added to aqueous medium. CsA-NS formulation was characterized and adjusted for particle size, pH, and osmolarity, suitable for ophthalmic administration. Thereafter, CsA-NS formulation was evaluated for parameters like irritation to eyes and penetrability of CsA in the rabbit eyes. Results obtained demonstrated that proposed CsA-NS formulation causes less irritation in rabbit eyes, with nearly same CsA penetration in the rabbit eyes in comparison to marketed ...","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"International journal of pharmaceutics"},"translated_abstract":"Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye disease, and is available commercially as ophthalmic emulsion formulation (RESTASIS(®)). For increasing efficacy, and for reducing local toxicity including irritation to eyes, CsA nanosphere (CsA-NS) formulation was prepared and evaluated, in this work. CsA-NS formulation was prepared in a pre-concentrate form, which is a homogeneous solution of a CsA in a mixture of surfactants, lipids and solvents and provides nanosphere dispersion when added to aqueous medium. CsA-NS formulation was characterized and adjusted for particle size, pH, and osmolarity, suitable for ophthalmic administration. Thereafter, CsA-NS formulation was evaluated for parameters like irritation to eyes and penetrability of CsA in the rabbit eyes. 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From mac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT The area of polymer–drug conjugates is expanding spectacularly in recent years. From macromolecular prodrugs of established anticancer agents to novel targeted polymeric drug conjugate systems, their application has expanded exponentially. Delivery of new anticancer agents, combination therapies, treatment of diseases other than cancer, and novel polymer architectures are highly exciting and promising areas. It is hoped that in the next decade, some of these new approaches will reach clinical evaluation and few will see the light of marketing phase. The successful development of first-generation polymer–drug conjugates in the mid-1980s and 1990s has inspired more recent studies assessing their potential as drug delivery platforms for combination therapy. These early works unveiled unexpected therapeutic benefits but raised new issues, in particular in relation to “system design.” A better understanding of how drug combinations impact on cellular and molecular mechanisms is needed to rationally design new therapeutics. 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Pathogenesis of coronary artery disease (CAD) is lead by the progression of atherosclerotic lacerations in coronary arteries. Percutaneous coronary intervention (PCI) using balloon angioplasty was introduced in 1979 and was majorly used in the treatment of these lesions. Introduction of bare metal stents (BMS) has revolutionized stenting procedures overcoming elastic recoil and reducing restenosis commonly associated with balloon angioplasty, but follow up studies have shown 20-30% prevalence of in-stent restenosis (ISR), this led to the development of drug eluting stents (DES). But long-term follow up studies have shown increased liability of stent thrombosis. Boosting the development of safer and effective DES expounding for therapies like biodegradable polymer based DES, polymer free DES, bioresorbable DES and combination DES to collectively reduce neointimal hyperplasia and promote endothelial healing. 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These closed bilayer phospholipid vesicles have witnessed many technical advances in recent years since their first development in 1965. Delivery of therapeutics by liposomes alters their biodistribution profile, which further enhances the therapeutic index of various drugs. Extensive research is being carried out using these nano drug delivery systems in diverse areas including the delivery of anti-cancer, anti-fungal, anti-inflammatory drugs and therapeutic genes. 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Solid lipid nanoparticles (SLN) easily diffuse the blood-brain barrier (BBB) due to their lipophilic nature. Furthermore, ligand conjugation on SLN surface enhances the targeting efficiency. Lactoferin (Lf) conjugated SLN system is first time attempted for effective brain targeting in this study. Preparation of Lf-modified docetaxel (DTX)-loaded SLN for proficient delivery of DTX to brain. DTX-loaded SLN were prepared using emulsification and solvent evaporation method and conjugation of Lf on SLN surface (C-SLN) was attained through carbodiimide chemistry. These lipidic nanoparticles were evaluated by DLS, AFM, FTIR, XRD techniques and in vitro release studies. Colloidal stability study was performed in biologically simulated environment (normal saline and serum). 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These lipidic nanoparticles were evaluated by DLS, AFM, FTIR, XRD techniques and in vitro release studies. Colloidal stability study was performed in biologically simulated environment (normal saline and serum). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470790"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470790/Cationic_Polymers_for_the_Delivery_of_Therapeutic_Nucleotides"><img alt="Research paper thumbnail of Cationic Polymers for the Delivery of Therapeutic Nucleotides" class="work-thumbnail" src="https://attachments.academia-assets.com/43091604/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470790/Cationic_Polymers_for_the_Delivery_of_Therapeutic_Nucleotides">Cationic Polymers for the Delivery of Therapeutic Nucleotides</a></div><div class="wp-workCard_item"><span>Polysaccharides</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8895e21cfaa3101ac44c1a9d2f7e4133" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091604,"asset_id":22470790,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091604/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470790"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470790"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470790; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8895e21cfaa3101ac44c1a9d2f7e4133" } } $('.js-work-strip[data-work-id=22470790]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470790,"title":"Cationic Polymers for the Delivery of Therapeutic Nucleotides","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Polysaccharides"},"translated_abstract":null,"internal_url":"https://www.academia.edu/22470790/Cationic_Polymers_for_the_Delivery_of_Therapeutic_Nucleotides","translated_internal_url":"","created_at":"2016-02-26T03:22:45.980-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":43091604,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091604/thumbnails/1.jpg","file_name":"Cationic_Polymers_for_the_Delivery_of_Th20160226-23992-p5lo6b.pdf","download_url":"https://www.academia.edu/attachments/43091604/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cationic_Polymers_for_the_Delivery_of_Th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091604/Cationic_Polymers_for_the_Delivery_of_Th20160226-23992-p5lo6b-libre.pdf?1456486236=\u0026response-content-disposition=attachment%3B+filename%3DCationic_Polymers_for_the_Delivery_of_Th.pdf\u0026Expires=1732504539\u0026Signature=Rc4maqSMeHnyoaWf20UGEJ0wiKmWAq5w4oKr-08BvUhjHlpyQXO-ms3Kq-bmwz8GpbFaXgkqtU89swUNJ0tw9LaEBnUTwNB~GhcsNrSckUlZqICmjMyxISFp8JJ0Gw~DNIVoqkZS7cpA9lr2BwJvR9b62V~cjl~wtQwC5ffrr6xV~buZATUuZByby-QAdxtMPFaJK5MK~yUNhOmMkEcUMrr30h3w9FmSS-QS5OGwEi1O8Et64T8nUo3JueBnuRlmBKKF13L8TieutZklB3UMJKJzGomBzzToN0n4uOeDt~lPoU2a385nwtnv3zkgNMo-dZWiegarqRmMyqJteypVQw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cationic_Polymers_for_the_Delivery_of_Therapeutic_Nucleotides","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[{"id":43091604,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091604/thumbnails/1.jpg","file_name":"Cationic_Polymers_for_the_Delivery_of_Th20160226-23992-p5lo6b.pdf","download_url":"https://www.academia.edu/attachments/43091604/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cationic_Polymers_for_the_Delivery_of_Th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091604/Cationic_Polymers_for_the_Delivery_of_Th20160226-23992-p5lo6b-libre.pdf?1456486236=\u0026response-content-disposition=attachment%3B+filename%3DCationic_Polymers_for_the_Delivery_of_Th.pdf\u0026Expires=1732504539\u0026Signature=Rc4maqSMeHnyoaWf20UGEJ0wiKmWAq5w4oKr-08BvUhjHlpyQXO-ms3Kq-bmwz8GpbFaXgkqtU89swUNJ0tw9LaEBnUTwNB~GhcsNrSckUlZqICmjMyxISFp8JJ0Gw~DNIVoqkZS7cpA9lr2BwJvR9b62V~cjl~wtQwC5ffrr6xV~buZATUuZByby-QAdxtMPFaJK5MK~yUNhOmMkEcUMrr30h3w9FmSS-QS5OGwEi1O8Et64T8nUo3JueBnuRlmBKKF13L8TieutZklB3UMJKJzGomBzzToN0n4uOeDt~lPoU2a385nwtnv3zkgNMo-dZWiegarqRmMyqJteypVQw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":16061,"name":"Polysaccharides","url":"https://www.academia.edu/Documents/in/Polysaccharides"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470788"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470788/p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation"><img alt="Research paper thumbnail of p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470788/p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation">p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation</a></div><div class="wp-workCard_item"><span>Journal of Nanoparticle Research</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1HNMR and FTIR spectroscopy. In vitro release of drug from DTX loaded pHBA conjugated dendrimer (CDN) was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere®). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470788"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470788"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470788; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470788]").text(description); $(".js-view-count[data-work-id=22470788]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470788; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470788']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470788, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22470788]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470788,"title":"p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation","translated_title":"","metadata":{"abstract":"ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1HNMR and FTIR spectroscopy. In vitro release of drug from DTX loaded pHBA conjugated dendrimer (CDN) was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere®). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Journal of Nanoparticle Research"},"translated_abstract":"ABSTRACT Dendrimers are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1HNMR and FTIR spectroscopy. In vitro release of drug from DTX loaded pHBA conjugated dendrimer (CDN) was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere®). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.","internal_url":"https://www.academia.edu/22470788/p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation","translated_internal_url":"","created_at":"2016-02-26T03:22:45.828-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"p_Hydroxy_benzoic_acid_conjugated_dendrimer_nanotherapeutics_as_potential_carriers_for_targeted_drug_delivery_to_brain_an_in_vitro_and_in_vivo_evaluation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[],"research_interests":[{"id":56,"name":"Materials Engineering","url":"https://www.academia.edu/Documents/in/Materials_Engineering"},{"id":8950,"name":"Nanoparticle","url":"https://www.academia.edu/Documents/in/Nanoparticle"},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles"},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology"},{"id":26694,"name":"Dendrimers","url":"https://www.academia.edu/Documents/in/Dendrimers"},{"id":429224,"name":"Sigma receptor","url":"https://www.academia.edu/Documents/in/Sigma_receptor"},{"id":1524090,"name":"Benzamides","url":"https://www.academia.edu/Documents/in/Benzamides"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470787"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470787/Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment"><img alt="Research paper thumbnail of Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470787/Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment">Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment</a></div><div class="wp-workCard_item"><span>Drug Delivery</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when usin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate property leads to poor oral bioavailability and efficacy. The objective of this study is to formulate and evaluate nanoparticles of RPM, along with a chemosensitizer (piperine, PIP) for improved oral bioavailability and efficacy. Poly(d,l-lactide-co-glycolide) (PLGA) was selected as polymer as it has moderate MDR reversal activity, which may provide additional benefits. The nanoprecipitation method was used to prepare PLGA nanoparticles with particle size below 150 nm, loaded with both drugs (RPM and PIP). Prepared nanoparticles showed sustained in vitro drug release for weeks, with initial release kinetics of zero order with non-Fickian transport, subsequently followed by Higuchi kinetics with Fickian diffusion. An everted gut sac method was used to study the effect of P-gp efflux on drug transport. This reveals that the uptake of the RPM (P-gp substrate) has been increased in the presence of chemosensitizer. Pharmacokinetic studies showed better absorption profile of RPM from polymeric nanoparticles compared to its suspension counterpart and improved bioavailability of 4.8-folds in combination with a chemosensitizer. An in vitro cell line study indicates higher efficacy of nanoparticles compared to free drug solution. Results suggest that the use of a combination of PIP with RPM nanoparticles would be a promising approach in the treatment of breast cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470787"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470787"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470787; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470787]").text(description); $(".js-view-count[data-work-id=22470787]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470787; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470787']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470787, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22470787]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470787,"title":"Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment","translated_title":"","metadata":{"abstract":"P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate property leads to poor oral bioavailability and efficacy. The objective of this study is to formulate and evaluate nanoparticles of RPM, along with a chemosensitizer (piperine, PIP) for improved oral bioavailability and efficacy. Poly(d,l-lactide-co-glycolide) (PLGA) was selected as polymer as it has moderate MDR reversal activity, which may provide additional benefits. The nanoprecipitation method was used to prepare PLGA nanoparticles with particle size below 150 nm, loaded with both drugs (RPM and PIP). Prepared nanoparticles showed sustained in vitro drug release for weeks, with initial release kinetics of zero order with non-Fickian transport, subsequently followed by Higuchi kinetics with Fickian diffusion. An everted gut sac method was used to study the effect of P-gp efflux on drug transport. This reveals that the uptake of the RPM (P-gp substrate) has been increased in the presence of chemosensitizer. Pharmacokinetic studies showed better absorption profile of RPM from polymeric nanoparticles compared to its suspension counterpart and improved bioavailability of 4.8-folds in combination with a chemosensitizer. An in vitro cell line study indicates higher efficacy of nanoparticles compared to free drug solution. Results suggest that the use of a combination of PIP with RPM nanoparticles would be a promising approach in the treatment of breast cancer.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Drug Delivery"},"translated_abstract":"P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate property leads to poor oral bioavailability and efficacy. The objective of this study is to formulate and evaluate nanoparticles of RPM, along with a chemosensitizer (piperine, PIP) for improved oral bioavailability and efficacy. Poly(d,l-lactide-co-glycolide) (PLGA) was selected as polymer as it has moderate MDR reversal activity, which may provide additional benefits. The nanoprecipitation method was used to prepare PLGA nanoparticles with particle size below 150 nm, loaded with both drugs (RPM and PIP). Prepared nanoparticles showed sustained in vitro drug release for weeks, with initial release kinetics of zero order with non-Fickian transport, subsequently followed by Higuchi kinetics with Fickian diffusion. An everted gut sac method was used to study the effect of P-gp efflux on drug transport. This reveals that the uptake of the RPM (P-gp substrate) has been increased in the presence of chemosensitizer. Pharmacokinetic studies showed better absorption profile of RPM from polymeric nanoparticles compared to its suspension counterpart and improved bioavailability of 4.8-folds in combination with a chemosensitizer. An in vitro cell line study indicates higher efficacy of nanoparticles compared to free drug solution. Results suggest that the use of a combination of PIP with RPM nanoparticles would be a promising approach in the treatment of breast cancer.","internal_url":"https://www.academia.edu/22470787/Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment","translated_internal_url":"","created_at":"2016-02-26T03:22:45.653-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Co_delivery_of_rapamycin_and_piperine_loaded_polymeric_nanoparticles_for_breast_cancer_treatment","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470786"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470786/Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials"><img alt="Research paper thumbnail of Alternative Antimicrobial Approach: Nano-Antimicrobial Materials" class="work-thumbnail" src="https://attachments.academia-assets.com/43091600/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470786/Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials">Alternative Antimicrobial Approach: Nano-Antimicrobial Materials</a></div><div class="wp-workCard_item"><span>Evidence-Based Complementary and Alternative Medicine</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6345e5fe6b0964c71e41f88b21e2ad65" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091600,"asset_id":22470786,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091600/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470786"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470786"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470786; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470786]").text(description); $(".js-view-count[data-work-id=22470786]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470786; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470786']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470786, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6345e5fe6b0964c71e41f88b21e2ad65" } } $('.js-work-strip[data-work-id=22470786]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470786,"title":"Alternative Antimicrobial Approach: Nano-Antimicrobial Materials","translated_title":"","metadata":{"grobid_abstract":"Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Evidence-Based Complementary and Alternative Medicine","grobid_abstract_attachment_id":43091600},"translated_abstract":null,"internal_url":"https://www.academia.edu/22470786/Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials","translated_internal_url":"","created_at":"2016-02-26T03:22:45.450-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":43091600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091600/thumbnails/1.jpg","file_name":"246012.pdf","download_url":"https://www.academia.edu/attachments/43091600/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alternative_Antimicrobial_Approach_Nano.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091600/246012-libre.pdf?1456486242=\u0026response-content-disposition=attachment%3B+filename%3DAlternative_Antimicrobial_Approach_Nano.pdf\u0026Expires=1732504539\u0026Signature=QURYXlpFYWDt1y4AReb3vgR8eZW36unhuK7EaiJ5DcKvs5gY4sl-27osRa9PrsEDL3Pq3qIWFgDEFKlNLJ1E-wuU~qRyri5NUEr1zgrZ3sRfhzkjB6syn3Hl0DXfhiKZtZJpdkARioT65NG0GRqt-N6AZsgRFB3oxLl16BwvXrcfa4-Y9dwx4cWA1~wH-iwldeX1KFLCMirITnbFfVl~L6fgQ4K8rAd0saMr-rSRBHBKj07Zw2y~w0K857fDiZgQP4GsRPU1Gd5dEVL~K5xjrJMt5-~uughpWTxfyzRujrc5XhtQGOvzuDyZHAHHQy1OOdbbNrsz7YBO0JkmoQogQA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alternative_Antimicrobial_Approach_Nano_Antimicrobial_Materials","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[{"id":43091600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091600/thumbnails/1.jpg","file_name":"246012.pdf","download_url":"https://www.academia.edu/attachments/43091600/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alternative_Antimicrobial_Approach_Nano.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091600/246012-libre.pdf?1456486242=\u0026response-content-disposition=attachment%3B+filename%3DAlternative_Antimicrobial_Approach_Nano.pdf\u0026Expires=1732504539\u0026Signature=QURYXlpFYWDt1y4AReb3vgR8eZW36unhuK7EaiJ5DcKvs5gY4sl-27osRa9PrsEDL3Pq3qIWFgDEFKlNLJ1E-wuU~qRyri5NUEr1zgrZ3sRfhzkjB6syn3Hl0DXfhiKZtZJpdkARioT65NG0GRqt-N6AZsgRFB3oxLl16BwvXrcfa4-Y9dwx4cWA1~wH-iwldeX1KFLCMirITnbFfVl~L6fgQ4K8rAd0saMr-rSRBHBKj07Zw2y~w0K857fDiZgQP4GsRPU1Gd5dEVL~K5xjrJMt5-~uughpWTxfyzRujrc5XhtQGOvzuDyZHAHHQy1OOdbbNrsz7YBO0JkmoQogQA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470785"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470785/Adenosine_conjugated_lipidic_nanoparticles_for_enhanced_tumor_targeting"><img alt="Research paper thumbnail of Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting" class="work-thumbnail" src="https://attachments.academia-assets.com/43091611/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470785/Adenosine_conjugated_lipidic_nanoparticles_for_enhanced_tumor_targeting">Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting</a></div><div class="wp-workCard_item"><span>International journal of pharmaceutics</span><span>, Jan 31, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonsp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs. The present study was performed to investigate the efficiency of adenosine (ADN) to target solid lipid nanoparticles (SLN) to over expressing adenosine receptor cell lines such as human breast cancer and prostate cancer (MCF-7 and DU-145 cells), respectively. SLN were prepared by emulsification and solvent evaporation process using docetaxel (DTX) as drug and were characterized by various techniques like dynamic light scattering, differential scanning calorimeter and transmission electron microscopy. DTX loaded SLNs were surface modified with ADN, an adenosine receptors ligand using carbodiimide coupling. Conjugation was confirmed using infrared spectroscopy and quantified using ph...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6676bc1eb572cfa85c5b7d0d963a67f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091611,"asset_id":22470785,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091611/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470785"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470785"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470785; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470785]").text(description); $(".js-view-count[data-work-id=22470785]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470785; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470785']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470785, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6676bc1eb572cfa85c5b7d0d963a67f3" } } $('.js-work-strip[data-work-id=22470785]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470785,"title":"Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting","translated_title":"","metadata":{"abstract":"Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs. The present study was performed to investigate the efficiency of adenosine (ADN) to target solid lipid nanoparticles (SLN) to over expressing adenosine receptor cell lines such as human breast cancer and prostate cancer (MCF-7 and DU-145 cells), respectively. SLN were prepared by emulsification and solvent evaporation process using docetaxel (DTX) as drug and were characterized by various techniques like dynamic light scattering, differential scanning calorimeter and transmission electron microscopy. DTX loaded SLNs were surface modified with ADN, an adenosine receptors ligand using carbodiimide coupling. Conjugation was confirmed using infrared spectroscopy and quantified using ph...","publication_date":{"day":31,"month":1,"year":2015,"errors":{}},"publication_name":"International journal of pharmaceutics"},"translated_abstract":"Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs. The present study was performed to investigate the efficiency of adenosine (ADN) to target solid lipid nanoparticles (SLN) to over expressing adenosine receptor cell lines such as human breast cancer and prostate cancer (MCF-7 and DU-145 cells), respectively. SLN were prepared by emulsification and solvent evaporation process using docetaxel (DTX) as drug and were characterized by various techniques like dynamic light scattering, differential scanning calorimeter and transmission electron microscopy. DTX loaded SLNs were surface modified with ADN, an adenosine receptors ligand using carbodiimide coupling. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470784"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470784/p_Aminophenyl_%CE%B1_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain"><img alt="Research paper thumbnail of p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain" class="work-thumbnail" src="https://attachments.academia-assets.com/43091605/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470784/p_Aminophenyl_%CE%B1_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain">p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain</a></div><div class="wp-workCard_item"><span>Chemistry and physics of lipids</span><span>, Jan 25, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metab...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metabolic substrates like carbohydrates and amino acids are able to traverse the blood-brain barrier (BBB) by specific carrier-mediated transport systems like glucose transporters present on the both luminal and abluminal side of the BBB. With this objective, the docetaxel (DTX) loaded solid lipidic nanoparticles were formulated and surface modified with a mannose derived ligand p-aminophenyl-α-d-mannopyranoside (MAN) to develop MAN conjugated lipidic nanoparticles for targeting DTX to brain. Lipidic nanoparticles were prepared using emulsification and solvent evaporation method using stearic acid as charge modifying lipid and conjugated with MAN using carbodimide coupling. These lipidic nanoparticles were successfully characterized using various techniques like DLS, TEM, DSC and FTIR spectroscopy. Cytotoxicity and cell uptake unveiled enhanced efficacy of conjugated lipidic nanoparticles. Ph...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c4a899e5b6bb4287954c4a671389987c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43091605,"asset_id":22470784,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43091605/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470784"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470784"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470784; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470784]").text(description); $(".js-view-count[data-work-id=22470784]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470784; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470784']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470784, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c4a899e5b6bb4287954c4a671389987c" } } $('.js-work-strip[data-work-id=22470784]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470784,"title":"p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain","translated_title":"","metadata":{"abstract":"Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metabolic substrates like carbohydrates and amino acids are able to traverse the blood-brain barrier (BBB) by specific carrier-mediated transport systems like glucose transporters present on the both luminal and abluminal side of the BBB. With this objective, the docetaxel (DTX) loaded solid lipidic nanoparticles were formulated and surface modified with a mannose derived ligand p-aminophenyl-α-d-mannopyranoside (MAN) to develop MAN conjugated lipidic nanoparticles for targeting DTX to brain. Lipidic nanoparticles were prepared using emulsification and solvent evaporation method using stearic acid as charge modifying lipid and conjugated with MAN using carbodimide coupling. These lipidic nanoparticles were successfully characterized using various techniques like DLS, TEM, DSC and FTIR spectroscopy. Cytotoxicity and cell uptake unveiled enhanced efficacy of conjugated lipidic nanoparticles. Ph...","publication_date":{"day":25,"month":1,"year":2015,"errors":{}},"publication_name":"Chemistry and physics of lipids"},"translated_abstract":"Lipidic systems are considered to be the most promising carrier for drug delivery to brain. Metabolic substrates like carbohydrates and amino acids are able to traverse the blood-brain barrier (BBB) by specific carrier-mediated transport systems like glucose transporters present on the both luminal and abluminal side of the BBB. With this objective, the docetaxel (DTX) loaded solid lipidic nanoparticles were formulated and surface modified with a mannose derived ligand p-aminophenyl-α-d-mannopyranoside (MAN) to develop MAN conjugated lipidic nanoparticles for targeting DTX to brain. Lipidic nanoparticles were prepared using emulsification and solvent evaporation method using stearic acid as charge modifying lipid and conjugated with MAN using carbodimide coupling. These lipidic nanoparticles were successfully characterized using various techniques like DLS, TEM, DSC and FTIR spectroscopy. Cytotoxicity and cell uptake unveiled enhanced efficacy of conjugated lipidic nanoparticles. Ph...","internal_url":"https://www.academia.edu/22470784/p_Aminophenyl_%CE%B1_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain","translated_internal_url":"","created_at":"2016-02-26T03:22:45.065-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":16474613,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":43091605,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091605/thumbnails/1.jpg","file_name":"p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm.pdf","download_url":"https://www.academia.edu/attachments/43091605/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"p_Aminophenyl__d_mannopyranoside_engine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091605/p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm-libre.pdf?1456486248=\u0026response-content-disposition=attachment%3B+filename%3Dp_Aminophenyl__d_mannopyranoside_engine.pdf\u0026Expires=1732504540\u0026Signature=JPW1dQRmsg2cwUtR08c9TgO6D5a7PczwCIjJ9fGtO9F~lT03h6n4TuMfnM3nWt1966HusFFwwRNyZZ355Vuyp8ZMKikHKdgol8iyn~gD3vvM2T6~V3C626wrYLRLR6NqWrlSBwrkZs6QJcjTAi3qqkCTZxTLajnTKblnHpK6q1gnJ3rX88XAzRNr9fINDU5rptXgeV5nQRFV3IYUEwXQJWgYh~q3-tq79QTe1eq0FTz9cQe10X29NWD-SRehbQttOo1txOxu2SkrbV8PwqvH5SbV5Q08TM7pcn99A8lxL0hJ-EwiIu7uLWvTHHthlIHTcceuKxL07sBS3WVV2ecg2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"p_Aminophenyl_α_d_mannopyranoside_engineered_lipidic_nanoparticles_for_effective_delivery_of_docetaxel_to_brain","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":16474613,"first_name":"Wahid","middle_initials":null,"last_name":"Khan","page_name":"WahidKhan","domain_name":"niperhyd1","created_at":"2014-09-11T15:08:21.750-07:00","display_name":"Wahid Khan","url":"https://niperhyd1.academia.edu/WahidKhan"},"attachments":[{"id":43091605,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43091605/thumbnails/1.jpg","file_name":"p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm.pdf","download_url":"https://www.academia.edu/attachments/43091605/download_file?st=MTczMjUwNjU0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"p_Aminophenyl__d_mannopyranoside_engine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43091605/p-Aminophenyl--d-mannopyranoside_enginee20160226-27795-k9l4fm-libre.pdf?1456486248=\u0026response-content-disposition=attachment%3B+filename%3Dp_Aminophenyl__d_mannopyranoside_engine.pdf\u0026Expires=1732504540\u0026Signature=JPW1dQRmsg2cwUtR08c9TgO6D5a7PczwCIjJ9fGtO9F~lT03h6n4TuMfnM3nWt1966HusFFwwRNyZZ355Vuyp8ZMKikHKdgol8iyn~gD3vvM2T6~V3C626wrYLRLR6NqWrlSBwrkZs6QJcjTAi3qqkCTZxTLajnTKblnHpK6q1gnJ3rX88XAzRNr9fINDU5rptXgeV5nQRFV3IYUEwXQJWgYh~q3-tq79QTe1eq0FTz9cQe10X29NWD-SRehbQttOo1txOxu2SkrbV8PwqvH5SbV5Q08TM7pcn99A8lxL0hJ-EwiIu7uLWvTHHthlIHTcceuKxL07sBS3WVV2ecg2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22470783"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22470783/Cyclosporin_nanosphere_formulation_for_ophthalmic_administration"><img alt="Research paper thumbnail of Cyclosporin nanosphere formulation for ophthalmic administration" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22470783/Cyclosporin_nanosphere_formulation_for_ophthalmic_administration">Cyclosporin nanosphere formulation for ophthalmic administration</a></div><div class="wp-workCard_item"><span>International journal of pharmaceutics</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye diseas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye disease, and is available commercially as ophthalmic emulsion formulation (RESTASIS(®)). For increasing efficacy, and for reducing local toxicity including irritation to eyes, CsA nanosphere (CsA-NS) formulation was prepared and evaluated, in this work. CsA-NS formulation was prepared in a pre-concentrate form, which is a homogeneous solution of a CsA in a mixture of surfactants, lipids and solvents and provides nanosphere dispersion when added to aqueous medium. CsA-NS formulation was characterized and adjusted for particle size, pH, and osmolarity, suitable for ophthalmic administration. Thereafter, CsA-NS formulation was evaluated for parameters like irritation to eyes and penetrability of CsA in the rabbit eyes. Results obtained demonstrated that proposed CsA-NS formulation causes less irritation in rabbit eyes, with nearly same CsA penetration in the rabbit eyes in comparison to marketed ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22470783"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22470783"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22470783; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22470783]").text(description); $(".js-view-count[data-work-id=22470783]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22470783; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22470783']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22470783, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22470783]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22470783,"title":"Cyclosporin nanosphere formulation for ophthalmic administration","translated_title":"","metadata":{"abstract":"Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye disease, and is available commercially as ophthalmic emulsion formulation (RESTASIS(®)). For increasing efficacy, and for reducing local toxicity including irritation to eyes, CsA nanosphere (CsA-NS) formulation was prepared and evaluated, in this work. CsA-NS formulation was prepared in a pre-concentrate form, which is a homogeneous solution of a CsA in a mixture of surfactants, lipids and solvents and provides nanosphere dispersion when added to aqueous medium. CsA-NS formulation was characterized and adjusted for particle size, pH, and osmolarity, suitable for ophthalmic administration. Thereafter, CsA-NS formulation was evaluated for parameters like irritation to eyes and penetrability of CsA in the rabbit eyes. Results obtained demonstrated that proposed CsA-NS formulation causes less irritation in rabbit eyes, with nearly same CsA penetration in the rabbit eyes in comparison to marketed ...","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"International journal of pharmaceutics"},"translated_abstract":"Cyclosporin A (CsA) is a widely used anti-inflammatory agent for the management of dry eye disease, and is available commercially as ophthalmic emulsion formulation (RESTASIS(®)). For increasing efficacy, and for reducing local toxicity including irritation to eyes, CsA nanosphere (CsA-NS) formulation was prepared and evaluated, in this work. CsA-NS formulation was prepared in a pre-concentrate form, which is a homogeneous solution of a CsA in a mixture of surfactants, lipids and solvents and provides nanosphere dispersion when added to aqueous medium. CsA-NS formulation was characterized and adjusted for particle size, pH, and osmolarity, suitable for ophthalmic administration. Thereafter, CsA-NS formulation was evaluated for parameters like irritation to eyes and penetrability of CsA in the rabbit eyes. 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From mac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT The area of polymer–drug conjugates is expanding spectacularly in recent years. From macromolecular prodrugs of established anticancer agents to novel targeted polymeric drug conjugate systems, their application has expanded exponentially. Delivery of new anticancer agents, combination therapies, treatment of diseases other than cancer, and novel polymer architectures are highly exciting and promising areas. It is hoped that in the next decade, some of these new approaches will reach clinical evaluation and few will see the light of marketing phase. The successful development of first-generation polymer–drug conjugates in the mid-1980s and 1990s has inspired more recent studies assessing their potential as drug delivery platforms for combination therapy. These early works unveiled unexpected therapeutic benefits but raised new issues, in particular in relation to “system design.” A better understanding of how drug combinations impact on cellular and molecular mechanisms is needed to rationally design new therapeutics. 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Pathogenesis of coronary artery disease (CAD) is lead by the progression of atherosclerotic lacerations in coronary arteries. Percutaneous coronary intervention (PCI) using balloon angioplasty was introduced in 1979 and was majorly used in the treatment of these lesions. Introduction of bare metal stents (BMS) has revolutionized stenting procedures overcoming elastic recoil and reducing restenosis commonly associated with balloon angioplasty, but follow up studies have shown 20-30% prevalence of in-stent restenosis (ISR), this led to the development of drug eluting stents (DES). But long-term follow up studies have shown increased liability of stent thrombosis. Boosting the development of safer and effective DES expounding for therapies like biodegradable polymer based DES, polymer free DES, bioresorbable DES and combination DES to collectively reduce neointimal hyperplasia and promote endothelial healing. In dual-DES development, a combination employing an anti-restenotic agent (for preventing VSMC's proliferation), which is released for the first few weeks, and then the second drug a pro-healing agent (promoting re-endothelialization) released after a month would be ideal. 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