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role="main"><div id="main-content" tabindex="-1"></div><div class="section"><div class="block block--content" id="block-mainpagecontent-2"><article><h1>Research in Action</h1><p>Lists of accomplishments and honors fail to provide insights into the process of discovery and the day-to-day interactions that made them possible. In these brief pieces, you will learn about the individuals that make up the Intramural Research Program (IRP). In addition to learning about their goals and achievements, you will learn about their inspirational moments, their individual roads to discovery, and most of all, why they are passionate about the research that they do in the IRP.</p><h2 class="text-align-center">In This Section</h2><ul class="overviewlinks"><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/shaping-therapies-for-sickle-cell-disease"><div class="overviewlinks__heading"><h3>Shaping Therapies for Sickle Cell Disease</h3></div><div class="overviewlinks__text"><p>Swee Lay Thein is hunting for new ways to help patients with deformed red blood cells.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/the-minds-map-maker"><div class="overviewlinks__heading"><h3>The Mind's Map Maker</h3></div><div class="overviewlinks__text"><p>Yi Gu is on a journey to find out how the brain learns the lay of the land.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/a-reboot-for-your-blood"><div class="overviewlinks__heading"><h3>A Reboot For Your Blood</h3></div><div class="overviewlinks__text"><p>Shahinaz Gadalla aims to improve outcomes for stem cell transplants.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/preserving-cellular-health-during-aging"><div class="overviewlinks__heading"><h3>Preserving Cellular Health During Aging</h3></div><div class="overviewlinks__text"><p>Nathan Basisty looks for molecular markers to assess biological age and prevent future disease.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/ancient-genes-modern-diseases"><div class="overviewlinks__heading"><h3>Ancient Genes, Modern Diseases</h3></div><div class="overviewlinks__text"><p>Neil Hanchard searches for genetic secrets in the birthplace of humanity.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/too-much-of-a-good-thing"><div class="overviewlinks__heading"><h3>Too Much of a Good Thing</h3></div><div class="overviewlinks__text"><p>Yaron Rotman seeks treatments for an increasingly common cause of liver injury.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/turning-face-perception-on-its-head"><div class="overviewlinks__heading"><h3>Turning Face Perception on Its Head</h3></div><div class="overviewlinks__text"><p>David Leopold is devising new ways to study how our brains process social cues.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/safeguarding-a-second-chance-at-life"><div class="overviewlinks__heading"><h3>Safeguarding a Second Chance at Life</h3></div><div class="overviewlinks__text"><p>Sean Agbor-Enoh uses an innovative test to predict complications in organ transplant recipients.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/a-biological-betrayal"><div class="overviewlinks__heading"><h3>A Biological Betrayal</h3></div><div class="overviewlinks__text"><p>Mariana Kaplan aims to stop the immune system from harming the cells it is supposed to defend.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/how-to-feast-for-your-eyes"><div class="overviewlinks__heading"><h3>How to Feast for Your Eyes</h3></div><div class="overviewlinks__text"><p>Emily Chew has a vision to reduce the risk of eye disease by filling gaps in nutrition.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/viruses-on-the-brain"><div class="overviewlinks__heading"><h3>Viruses on the Brain</h3></div><div class="overviewlinks__text"><p>Avindra Nath investigates the mysterious ways viruses affect the nervous system.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/reprogramming-cancer"><div class="overviewlinks__heading"><h3>Reprogramming Cancer</h3></div><div class="overviewlinks__text"><p>David Takeda is laying the groundwork for a bold new approach to cancer therapy.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/smart-devices-for-better-health"><div class="overviewlinks__heading"><h3>Smart Devices for Better Health</h3></div><div class="overviewlinks__text"><p>Sherine El-Toukhy leverages digital technologies to improve access to healthcare.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/nothing-to-sniff-at"><div class="overviewlinks__heading"><h3>Nothing to Sniff At</h3></div><div class="overviewlinks__text"><p>Paule Joseph explores how variations in taste and smell might contribute to obesity and addiction.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/shining-a-light-on-emotion"><div class="overviewlinks__heading"><h3>Shining a Light on Emotion</h3></div><div class="overviewlinks__text"><p>Mario Penzo uses cutting-edge genetic techniques to observe and influence brain circuits involved in stress and anxiety.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/virtual-realities-real-discoveries"><div class="overviewlinks__heading"><h3>Virtual Realities, Real Discoveries</h3></div><div class="overviewlinks__text"><p>Susan Persky uses immersive simulations to understand how genomic information influences people’s health behaviors.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/a-feel-for-collaboration"><div class="overviewlinks__heading"><h3>A Feel For Collaboration</h3></div><div class="overviewlinks__text"><p>Alex Chesler works with colleagues across the IRP to uncover the mysteries of touch and pain.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/a-broken-link-in-the-chain"><div class="overviewlinks__heading"><h3>A Broken Link in the Chain</h3></div><div class="overviewlinks__text"><p>Janet Hall explores the cascading effects of hormonal disruptions on the reproductive system.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/cracking-the-tubulin-code"><div class="overviewlinks__heading"><h3>Cracking the Tubulin Code</h3></div><div class="overviewlinks__text"><p>Antonina Roll-Mecak examines how tubulin diversity might affect cell shape, movement, and recovery after injury.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/energized-by-fatigue"><div class="overviewlinks__heading"><h3>Energized by Fatigue</h3></div><div class="overviewlinks__text"><p>Leorey Saligan works as a nurse and scientist to improve both quality of life and therapeutic outcomes for patients suffering from fatigue.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/teaming-up-for-change"><div class="overviewlinks__heading"><h3>Teaming Up for Change</h3></div><div class="overviewlinks__text"><p>Elizabeth Rasch and her multidisciplinary team develop better ways to measure disability.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/the-long-road-to-understanding-kidney-cancer"><div class="overviewlinks__heading"><h3>The Long Road to Understanding Kidney Cancer</h3></div><div class="overviewlinks__text"><p>W. Marston Linehan investigates kidney cancer gene pathways to find new treatment strategies.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/one-gene-three-disorders-and-no-cures"><div class="overviewlinks__heading"><h3>One Gene, Three Disorders, and No Cures</h3></div><div class="overviewlinks__text"><p>Karen Usdin investigates how multiple copies of a short DNA repeat give rise to the Fragile X-related disorders.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/finding-the-perfect-target"><div class="overviewlinks__heading"><h3>Finding the Perfect Target</h3></div><div class="overviewlinks__text"><p>Tongqing Zhou brings the tools of structural biology to the search for an HIV vaccine.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/found-in-translation"><div class="overviewlinks__heading"><h3>Found in Translation</h3></div><div class="overviewlinks__text"><p>Bibiana Bielekova moves from the bench to the bedside and back again in pursuit of a cure for multiple sclerosis.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/changing-cells-aging-bodies"><div class="overviewlinks__heading"><h3>Changing Cells, Aging Bodies</h3></div><div class="overviewlinks__text"><p>Myriam Gorospe views aging through a molecular lens to help lengthen healthspan.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/high-fidelity-stereocilia"><div class="overviewlinks__heading"><h3>High-Fidelity Stereocilia</h3></div><div class="overviewlinks__text"><p>Bechara Kachar uses high-tech imaging to understand the cell biology of hearing.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/scientists-with-talent"><div class="overviewlinks__heading"><h3>Scientists with TALEN(t)!</h3></div><div class="overviewlinks__text"><p>By manipulating the mouse genome, Rafael Casellas brings human gene therapy closer to reality.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/plastic-brains"><div class="overviewlinks__heading"><h3>Plastic Brains</h3></div><div class="overviewlinks__text"><p>Jerrel Yakel studies the neural circuits that underlie learning and memory.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/from-despair-to-hope-in-hours"><div class="overviewlinks__heading"><h3>From Despair to Hope in Hours</h3></div><div class="overviewlinks__text"><p>Carlos Zarate speeds up treatment for major depression.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" 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href="/our-research/research-in-action/research-into-the-realm-of-risk"><div class="overviewlinks__heading"><h3>Research into the Realm of Risk</h3></div><div class="overviewlinks__text"><p>Caroline Fox investigates risk factors associated with cardiovascular disease.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/taking-the-long-view"><div class="overviewlinks__heading"><h3>Taking the Long View</h3></div><div class="overviewlinks__text"><p>Mark Schiffman uses molecular epidemiology to predict and prevent cervical cancer.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/decoding-telomere-biology-and-cancer-risk"><div class="overviewlinks__heading"><h3>Decoding Telomere Biology and Cancer Risk</h3></div><div class="overviewlinks__text"><p>Sharon Savage guides a team to unraveling the secrets of our telomeres.</p></div></a></li><li 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class="overviewlinks__text"><p>Cheryl Cropp ventures away from the bench to dig into cancer data.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/building-bodily-cancer-defenses"><div class="overviewlinks__heading"><h3>Building Bodily Cancer Defenses</h3></div><div class="overviewlinks__text"><p>James Gulley provides new tools in the immune system’s fight against cancer.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/molecular-interventions"><div class="overviewlinks__heading"><h3>Molecular Interventions</h3></div><div class="overviewlinks__text"><p>Christina Annunziata brings her unique expertise to bear on the problem of ovarian cancer.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/from-the-mountains-to-the-clinic"><div class="overviewlinks__heading"><h3>From the Mountains to the Clinic</h3></div><div class="overviewlinks__text"><p>Sonja M. Best hunts for viruses that evade the immune system.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/the-microbiome-when-good-bugs-go-bad"><div class="overviewlinks__heading"><h3>The Microbiome: When Good Bugs Go Bad</h3></div><div class="overviewlinks__text"><p>Yasmine Belkaid explores the fine balance that exists between microbes and their hosts.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/an-eye-to-a-cure"><div class="overviewlinks__heading"><h3>An Eye to a Cure</h3></div><div class="overviewlinks__text"><p>Anand Swaroop aims to treat retinal diseases with cell-based therapies.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/contacts-far-and-wide"><div class="overviewlinks__heading"><h3>Contacts Far and Wide</h3></div><div class="overviewlinks__text"><p>Gary Felsenfeld celebrates 50 years at the NIH with an indefatigable research agenda.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/the-broken-leg-mystery"><div class="overviewlinks__heading"><h3>The Broken Leg Mystery</h3></div><div class="overviewlinks__text"><p>Michael Collins and his Clinical Center colleagues cure a teenager of a debilitating bone disorder.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/seeing-is-believing"><div class="overviewlinks__heading"><h3>Seeing Is Believing</h3></div><div class="overviewlinks__text"><p>Jennifer Lippincott-Schwartz peers into the life and death of cells.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/spell-checking-dna"><div class="overviewlinks__heading"><h3>Spell-Checking DNA</h3></div><div class="overviewlinks__text"><p>Thomas Kunkel inspects DNA replication fidelity for underpinnings of health and disease.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/to-see-or-not-to-see"><div class="overviewlinks__heading"><h3>To See or Not To See...</h3></div><div class="overviewlinks__text"><p>Owen Schwartz finds ways for scientists to visualize the previously unknown.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/ambitions-of-a-tool-maker"><div class="overviewlinks__heading"><h3>Ambitions of a Tool-Maker</h3></div><div class="overviewlinks__text"><p>Hari Shroff builds microscopes that shine light on the boundaries of neuroscience.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/algorithms-for-life"><div class="overviewlinks__heading"><h3>Algorithms for Life</h3></div><div class="overviewlinks__text"><p>Teresa Przytycka answers complex biological questions using computational tools.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/going-with-the-flow"><div class="overviewlinks__heading"><h3>Going With the Flow</h3></div><div class="overviewlinks__text"><p>Pratip Chattopadhyay develops cutting-edge tools to peer into the immune system.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/a-two-year-clinical-research-odyssey"><div class="overviewlinks__heading"><h3>A Two-year Clinical Research Odyssey</h3></div><div class="overviewlinks__text"><p>William Gahl searches for answers to some of the most confounding undiagnosed diseases.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/a-conviction-an-addiction-and-a-mouse"><div class="overviewlinks__heading"><h3>A Conviction, an Addiction, and a Mouse</h3></div><div class="overviewlinks__text"><p>Veronica Alvarez takes the path less traveled to understand addiction.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/seeking-better-vision"><div class="overviewlinks__heading"><h3>Seeking Better Vision</h3></div><div class="overviewlinks__text"><p>Brian Brooks looks for ways to help families with childhood blindness.</p></div></a></li><li class="overviewlinks__item"><a class="overviewlinks__link" href="/our-research/research-in-action/and-the-award-for-best-supporting-cell-goes-to"><div class="overviewlinks__heading"><h3>And the Award for Best Supporting Cell Goes To…</h3></div><div class="overviewlinks__text"><p>Lisa Cunningham uses cellular stress to protect the inner ear from chemotherapy.</p></div></a></li></ul><div class="updated"> <p class="updated__date"><small>This page was last updated 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