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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder | Borderline Personality Disorder and Emotion Dysregulation | Full Text</title> <meta name="citation_abstract" content="Clozapine is an atypical antipsychotic medicine which can cause significant side-effects. It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder. We explored the lived-experience of women in secure inpatient care who were prescribed clozapine for borderline personality disorder. Adult females (N = 20) participated in audio-taped semi-structured interviews. Transcripts were subject to thematic analysis. The central themes related to evaluation, wellbeing, understanding and self-management; for many, their subjective wellbeing on clozapine was preferred to prior levels of functioning and symptomatology, sometimes profoundly so. The negative and potentially adverse effects of clozapine were explained as regrettable but relatively unimportant. When psychological interventions are, at least initially, ineffective then clozapine treatment is likely to be evaluated positively by a group of women with borderline personality disorder in secure care despite the potential disadvantages."/> <meta name="journal_id" content="40479"/> <meta name="dc.title" content="Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder"/> <meta name="dc.source" content="Borderline Personality Disorder and Emotion Dysregulation 2016 3:1"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="BioMed Central"/> <meta name="dc.date" content="2016-10-07"/> <meta name="dc.type" content="Report"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2016 The Author(s)."/> <meta name="dc.rights" content="2016 The Author(s)."/> <meta name="dc.rightsAgent" content="reprints@biomedcentral.com"/> <meta name="dc.description" content="Clozapine is an atypical antipsychotic medicine which can cause significant side-effects. It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder. We explored the lived-experience of women in secure inpatient care who were prescribed clozapine for borderline personality disorder. Adult females (N = 20) participated in audio-taped semi-structured interviews. Transcripts were subject to thematic analysis. The central themes related to evaluation, wellbeing, understanding and self-management; for many, their subjective wellbeing on clozapine was preferred to prior levels of functioning and symptomatology, sometimes profoundly so. The negative and potentially adverse effects of clozapine were explained as regrettable but relatively unimportant. When psychological interventions are, at least initially, ineffective then clozapine treatment is likely to be evaluated positively by a group of women with borderline personality disorder in secure care despite the potential disadvantages."/> <meta name="prism.issn" content="2051-6673"/> <meta name="prism.publicationName" content="Borderline Personality Disorder and Emotion Dysregulation"/> <meta name="prism.publicationDate" content="2016-10-07"/> <meta name="prism.volume" content="3"/> <meta name="prism.number" content="1"/> <meta name="prism.section" content="Report"/> <meta name="prism.startingPage" content="1"/> <meta name="prism.endingPage" content="4"/> <meta name="prism.copyright" content="2016 The Author(s)."/> <meta name="prism.rightsAgent" content="reprints@biomedcentral.com"/> <meta name="prism.url" content="https://bpded.biomedcentral.com/articles/10.1186/s40479-016-0049-x"/> <meta name="prism.doi" content="doi:10.1186/s40479-016-0049-x"/> <meta name="citation_pdf_url" content="https://bpded.biomedcentral.com/counter/pdf/10.1186/s40479-016-0049-x"/> <meta name="citation_fulltext_html_url" content="https://bpded.biomedcentral.com/articles/10.1186/s40479-016-0049-x"/> <meta name="citation_journal_title" content="Borderline Personality Disorder and Emotion Dysregulation"/> <meta name="citation_journal_abbrev" content="bord personal disord emot dysregul"/> <meta name="citation_publisher" content="BioMed Central"/> <meta name="citation_issn" content="2051-6673"/> <meta name="citation_title" content="Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder"/> <meta name="citation_volume" content="3"/> <meta name="citation_issue" content="1"/> <meta name="citation_publication_date" content="2016/12"/> <meta name="citation_online_date" content="2016/10/07"/> <meta name="citation_firstpage" content="1"/> <meta name="citation_lastpage" content="4"/> <meta name="citation_article_type" content="Short report"/> <meta name="citation_fulltext_world_readable" content=""/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1186/s40479-016-0049-x"/> <meta name="DOI" content="10.1186/s40479-016-0049-x"/> <meta name="size" content="60316"/> <meta name="citation_doi" content="10.1186/s40479-016-0049-x"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1186/s40479-016-0049-x&api_key="/> <meta name="description" content="Clozapine is an atypical antipsychotic medicine which can cause significant side-effects. It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder. We explored the lived-experience of women in secure inpatient care who were prescribed clozapine for borderline personality disorder. Adult females (N = 20) participated in audio-taped semi-structured interviews. Transcripts were subject to thematic analysis. The central themes related to evaluation, wellbeing, understanding and self-management; for many, their subjective wellbeing on clozapine was preferred to prior levels of functioning and symptomatology, sometimes profoundly so. The negative and potentially adverse effects of clozapine were explained as regrettable but relatively unimportant. When psychological interventions are, at least initially, ineffective then clozapine treatment is likely to be evaluated positively by a group of women with borderline personality disorder in secure care despite the potential disadvantages."/> <meta name="dc.creator" content="Dickens, Geoffrey L."/> <meta name="dc.creator" content="Frogley, Catherine"/> <meta name="dc.creator" content="Mason, Fiona"/> <meta name="dc.creator" content="Anagnostakis, Katina"/> <meta name="dc.creator" content="Picchioni, Marco M."/> <meta name="dc.subject" content="Psychiatry"/> <meta name="dc.subject" content="Psychotherapy"/> <meta name="dc.subject" content="Forensic Psychiatry"/> <meta name="dc.subject" content="Child and Adolescent Psychiatry"/> <meta name="citation_reference" content="citation_journal_title=Lancet; citation_title=Borderline personality disorder; citation_author=K Lieb, MC Zanarini, C Schmahl, MM Linehan, PM Bohus; citation_volume=364; citation_publication_date=2004; citation_pages=453-61; citation_doi=10.1016/S0140-6736(04)16770-6; citation_id=CR1"/> <meta name="citation_reference" content="citation_journal_title=Psychiat Danub; citation_title=Suicidal attempts among emergency department patients: one-year of clinical experience; citation_author=S Elisei, N Verdolini, S Anastasi; citation_volume=24; citation_issue=Suppl 1; citation_publication_date=2012; citation_pages=140-2; citation_id=CR2"/> <meta name="citation_reference" content="citation_journal_title=J Behav Health Ser R; citation_title=Borderline personality disorder and high utilization of inpatient psychiatric hospitalization: concordance between research and clinical diagnosis; citation_author=KA Comtois, A Carmel; citation_volume=43; citation_publication_date=2016; citation_pages=272-80; citation_doi=10.1007/s11414-014-9416-9; citation_id=CR3"/> <meta name="citation_reference" content="citation_journal_title=BMC Psychiat; citation_title=Psychiatric disorders and clinical correlates of suicidal patients admitted to a psychiatric hospital in Tokyo; citation_author=N Hayashi, M Igarashi, A Imai, Y Osawa, K Utsumi, Y Ishikawa; citation_volume=10; citation_publication_date=2010; citation_pages=109; citation_doi=10.1186/1471-244X-10-109; citation_id=CR4"/> <meta name="citation_reference" content="citation_journal_title=Psychiat Quart; citation_title=Aggression in borderline personality disorder; citation_author=K Latalova, J Prasko; citation_volume=81; citation_publication_date=2010; citation_pages=239-51; citation_doi=10.1007/s11126-010-9133-3; citation_id=CR5"/> <meta name="citation_reference" content="Katsakou C, Marougka S, Barnicot K, Savill M, White H, Lockwood K, Priebe S. Recovery in borderline personality disorder: a qualitative study of service users’ perspectives. PLoS ONE. 2012;7(5). http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036517 ."/> <meta name="citation_reference" content="citation_title=Borderline personality disorder: treatment and management. (No. 78); citation_publication_date=2012; citation_id=CR7; citation_publisher=British Psychological Society"/> <meta name="citation_reference" content="citation_journal_title=Acta Psychiat Scand; citation_title=Dialectical behavior therapy for borderline personality disorder: theoretical and empirical foundations; citation_author=EN Shearin, MM Linehan; citation_volume=89 Supplement s379; citation_publication_date=1994; citation_pages=61-8; citation_doi=10.1111/j.1600-0447.1994.tb05820.x; citation_id=CR8"/> <meta name="citation_reference" content="citation_journal_title=Int J Psychiatry Clin Pract; citation_title=Medication for borderline personality disorder: a survey at a secure hospital; citation_author=C Haw, J Stubbs; citation_volume=15; citation_publication_date=2011; citation_pages=280-5; citation_doi=10.3109/13651501.2011.590211; citation_id=CR9"/> <meta name="citation_reference" content="citation_journal_title=Compr Psychiatry; citation_title=Clozapine treatment of borderline patients: a preliminary study; citation_author=FR Frankenberg, MC Zanarini; citation_volume=34; citation_publication_date=1993; citation_pages=402-5; citation_doi=10.1016/0010-440X(93)90065-C; citation_id=CR10"/> <meta name="citation_reference" content="citation_journal_title=J Clin Psychiatry; citation_title=Low-dose clozapine in acute and continuation treatment of severe borderline personality disorder; citation_author=F Benedetti, L Sforzini, C Colombo, C Maffei, E Smeraldi; citation_volume=59; citation_publication_date=1998; citation_pages=103-7; citation_doi=10.4088/JCP.v59n0302; citation_id=CR11"/> <meta name="citation_reference" content="citation_journal_title=Ann Clin Psychiatry; citation_title=A case series of clozapine for borderline personality disorder; citation_author=C Frogley, K Anagnostakis, S Mitchell, F Mason, D Taylor, G Dickens, MM Picchioni; citation_volume=25; citation_publication_date=2013; citation_pages=125-134; citation_id=CR12"/> <meta name="citation_reference" content="citation_journal_title=Qual Res Psychol; citation_title=Using thematic analysis in psychology; citation_author=V Braun, V Clarke; citation_volume=3; citation_publication_date=2006; citation_pages=77-101; citation_doi=10.1191/1478088706qp063oa; citation_id=CR13"/> <meta name="citation_reference" content="citation_journal_title=Ann Clin Psychiatry; citation_title=Clozapine in borderline personality disorder: a review of the evidence; citation_author=A Beri, J Boydell; citation_volume=26; citation_publication_date=2014; citation_pages=139-44; citation_id=CR14"/> <meta name="citation_reference" content="citation_journal_title=World Psychiatry; citation_title=Mentalization based treatment for borderline personality disorder; citation_author=A Bateman, P Fonagy; citation_volume=9; citation_publication_date=2010; citation_pages=11-5; citation_doi=10.1002/j.2051-5545.2010.tb00255.x; citation_id=CR15"/> <meta name="citation_reference" 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It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder. We explored the lived-experience of women in secure inpatient care who were prescribed clozapine for borderline personality disorder. Findings Adult females (N = 20) participated in audio-taped semi-structured interviews. Transcripts were subject to thematic analysis. The central themes related to evaluation, wellbeing, understanding and self-management; for many, their subjective wellbeing on clozapine was preferred to prior levels of functioning and symptomatology, sometimes profoundly so. The negative and potentially adverse effects of clozapine were explained as regrettable but relatively unimportant. Conclusions When psychological interventions are, at least initially, ineffective then clozapine treatment is likely to be evaluated positively by a group of women with borderline personality disorder in secure care despite the potential disadvantages."/> <meta property="og:image" content="https://media.springernature.com/full/springer-static/cover-hires/journal/40479"/> <script type="application/ld+json">{"mainEntity":{"headline":"Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder","description":"Clozapine is an atypical antipsychotic medicine which can cause significant side-effects. It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder. We explored the lived-experience of women in secure inpatient care who were prescribed clozapine for borderline personality disorder. Adult females (N = 20) participated in audio-taped semi-structured interviews. Transcripts were subject to thematic analysis. The central themes related to evaluation, wellbeing, understanding and self-management; for many, their subjective wellbeing on clozapine was preferred to prior levels of functioning and symptomatology, sometimes profoundly so. The negative and potentially adverse effects of clozapine were explained as regrettable but relatively unimportant. When psychological interventions are, at least initially, ineffective then clozapine treatment is likely to be evaluated positively by a group of women with borderline personality disorder in secure care despite the potential disadvantages.","datePublished":"2016-10-07T00:00:00Z","dateModified":"2016-10-07T00:00:00Z","pageStart":"1","pageEnd":"4","license":"http://creativecommons.org/publicdomain/zero/1.0/","sameAs":"https://doi.org/10.1186/s40479-016-0049-x","keywords":["Clozapine","Borderline personality disorder","Emotionally unstable personality disorder","Thematic analysis","Psychiatry","Psychotherapy","Forensic Psychiatry","Child and Adolescent Psychiatry"],"image":[],"isPartOf":{"name":"Borderline Personality Disorder and Emotion Dysregulation","issn":["2051-6673"],"volumeNumber":"3","@type":["Periodical","PublicationVolume"]},"publisher":{"name":"BioMed Central","logo":{"url":"https://www.springernature.com/app-sn/public/images/logo-springernature.png","@type":"ImageObject"},"@type":"Organization"},"author":[{"name":"Geoffrey L. Dickens","affiliation":[{"name":"Abertay University","address":{"name":"Division of Mental Health Nursing and Counselling, School of Social and Health Sciences, Abertay University, Dundee, UK","@type":"PostalAddress"},"@type":"Organization"}],"email":"g.dickens@abertay.ac.uk","@type":"Person"},{"name":"Catherine Frogley","affiliation":[{"name":"St Andrew’s Academic Centre","address":{"name":"St Andrew’s Academic Centre, Northampton, UK","@type":"PostalAddress"},"@type":"Organization"},{"name":"University of Surrey","address":{"name":"School of Psychology, Faculty of Arts and Human Sciences, AD Building, University of Surrey, Guildford, UK","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"},{"name":"Fiona Mason","affiliation":[{"name":"St Andrew’s Academic Centre","address":{"name":"St Andrew’s Academic Centre, Northampton, UK","@type":"PostalAddress"},"@type":"Organization"},{"name":"University of Buckingham, Yeomanry House","address":{"name":"Medical School, University of Buckingham, Yeomanry House, Buckingham, UK","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"},{"name":"Katina Anagnostakis","affiliation":[{"name":"St Andrew’s Academic Centre","address":{"name":"St Andrew’s Academic Centre, Northampton, UK","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"},{"name":"Marco M. Picchioni","affiliation":[{"name":"St Andrew’s Academic Centre","address":{"name":"St Andrew’s Academic Centre, Northampton, UK","@type":"PostalAddress"},"@type":"Organization"},{"name":"King’s College London Institute of Psychiatry Psychology and Neuroscience","address":{"name":"Department of Forensic and Neurodevelopmental Science, King’s College London Institute of Psychiatry Psychology and Neuroscience, London, UK","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"}],"isAccessibleForFree":true,"@type":"ScholarlyArticle"},"@context":"https://schema.org","@type":"WebPage"}</script> </head> <body class="journal journal-fulltext" > <div class="ctm"></div>  <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MRVXSHQ" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript>  <div class="u-visually-hidden" aria-hidden="true"> <?xml version="1.0" encoding="UTF-8"?><!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN" 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article EPUB" data-track-label="10.1186/s40479-016-0049-x"> <span class="c-pdf-download__text">Download ePub</span> <svg aria-hidden="true" focusable="false" width="16" height="16" class="u-icon"> <use xlink:href="#icon-download"/> </svg> </a> </div> </div> </div> <article lang="en"> <div class="c-article-header"> <ul class="c-article-identifiers" data-test="article-identifier"> <li class="c-article-identifiers__item" data-test="article-category">Short report</li> <li class="c-article-identifiers__item"> <a href="https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research" data-track="click" data-track-action="open access" data-track-label="link" class="u-color-open-access" data-test="open-access">Open access</a> </li> <li class="c-article-identifiers__item">Published: <time datetime="2016-10-07">07 October 2016</time></li> </ul> <h1 class="c-article-title" data-test="article-title" data-article-title="">Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder</h1> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Geoffrey_L_-Dickens-Aff1" data-author-popup="auth-Geoffrey_L_-Dickens-Aff1" data-author-search="Dickens, Geoffrey L." data-corresp-id="c1">Geoffrey L. Dickens<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Catherine-Frogley-Aff2-Aff3" data-author-popup="auth-Catherine-Frogley-Aff2-Aff3" data-author-search="Frogley, Catherine">Catherine Frogley</a><sup class="u-js-hide"><a href="#Aff2">2</a>,<a href="#Aff3">3</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Fiona-Mason-Aff2-Aff4" data-author-popup="auth-Fiona-Mason-Aff2-Aff4" data-author-search="Mason, Fiona">Fiona Mason</a><sup class="u-js-hide"><a href="#Aff2">2</a>,<a href="#Aff4">4</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Katina-Anagnostakis-Aff2" data-author-popup="auth-Katina-Anagnostakis-Aff2" data-author-search="Anagnostakis, Katina">Katina Anagnostakis</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup> & </li><li class="c-article-author-list__show-more" aria-label="Show all 5 authors for this article" title="Show all 5 authors for this article">…</li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Marco_M_-Picchioni-Aff2-Aff5" data-author-popup="auth-Marco_M_-Picchioni-Aff2-Aff5" data-author-search="Picchioni, Marco M.">Marco M. Picchioni</a><sup class="u-js-hide"><a href="#Aff2">2</a>,<a href="#Aff5">5</a></sup> </li></ul><button aria-expanded="false" class="c-article-author-list__button"><svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-chevron-down-medium"></use></svg><span>Show authors</span></button> <p class="c-article-info-details" data-container-section="info"> <a data-test="journal-link" href="/" data-track="click" data-track-action="journal homepage" data-track-category="article body" data-track-label="link"><i data-test="journal-title">Borderline Personality Disorder and Emotion Dysregulation</i></a> <b data-test="journal-volume"><span class="u-visually-hidden">volume</span> 3</b>, Article number: <span data-test="article-number">12</span> (<span data-test="article-publication-year">2016</span>) <a href="#citeas" class="c-article-info-details__cite-as u-hide-print" data-track="click" data-track-action="cite this article" data-track-label="link">Cite this article</a> </p> <div class="c-article-metrics-bar__wrapper u-clear-both"> <ul class="c-article-metrics-bar u-list-reset"> <li class=" c-article-metrics-bar__item" data-test="access-count"> <p class="c-article-metrics-bar__count">6835 <span class="c-article-metrics-bar__label">Accesses</span></p> </li> <li class="c-article-metrics-bar__item" data-test="altmetric-score"> <p class="c-article-metrics-bar__count">8 <span class="c-article-metrics-bar__label">Altmetric</span></p> </li> <li class="c-article-metrics-bar__item"> <p class="c-article-metrics-bar__details"><a href="/articles/10.1186/s40479-016-0049-x/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Metrics <span class="u-visually-hidden">details</span></a></p> </li> </ul> </div> </div> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Background</h3><p>Clozapine is an atypical antipsychotic medicine which can cause significant side-effects. It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder. We explored the lived-experience of women in secure inpatient care who were prescribed clozapine for borderline personality disorder.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Findings</h3><p>Adult females (<i>N</i> = 20) participated in audio-taped semi-structured interviews. Transcripts were subject to thematic analysis. The central themes related to evaluation, wellbeing, understanding and self-management; for many, their subjective wellbeing on clozapine was preferred to prior levels of functioning and symptomatology, sometimes profoundly so. The negative and potentially adverse effects of clozapine were explained as regrettable but relatively unimportant.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Conclusions</h3><p>When psychological interventions are, at least initially, ineffective then clozapine treatment is likely to be evaluated positively by a group of women with borderline personality disorder in secure care despite the potential disadvantages.</p></div></div></section> <section data-title="Background"><div class="c-article-section" id="Sec1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Sec1">Background</h2><div class="c-article-section__content" id="Sec1-content"><p>People with borderline personality disorder (BPD) experience pervasive instability of affect, self-image, impulse control, behaviour, and relationships [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 1" title="Lieb K, Zanarini MC, Schmahl C, Linehan MM, Bohus PM. Borderline personality disorder. Lancet. 2004;364:453–61. doi:
 10.1016/S0140-6736(04)16770-6
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR1" id="ref-link-section-d338620504e525">1</a>]. Self-harm, use of emergency health services, and impulsive aggression are common [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 2" title="Elisei S, Verdolini N, Anastasi S. Suicidal attempts among emergency department patients: one-year of clinical experience. Psychiat Danub. 2012;24 Suppl 1:140–2." href="/articles/10.1186/s40479-016-0049-x#ref-CR2" id="ref-link-section-d338620504e528">2</a>–<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 5" title="Latalova K, Prasko J. Aggression in borderline personality disorder. Psychiat Quart. 2010;81:239–51. doi:
 10.1007/s11126-010-9133-3
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR5" id="ref-link-section-d338620504e531">5</a>]. Guidelines recommend psychosocial interventions [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 6" title="Katsakou C, Marougka S, Barnicot K, Savill M, White H, Lockwood K, Priebe S. Recovery in borderline personality disorder: a qualitative study of service users’ perspectives. PLoS ONE. 2012;7(5). 
 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036517
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR6" id="ref-link-section-d338620504e534">6</a>–<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 8" title="Shearin EN, Linehan MM. Dialectical behavior therapy for borderline personality disorder: theoretical and empirical foundations. Acta Psychiat Scand. 1994;89 Supplement s379:61–8. doi:
 10.1111/j.1600-0447.1994.tb05820.x
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR8" id="ref-link-section-d338620504e537">8</a>], limiting the role of medicines to crises or psychiatric co-morbidity. Nevertheless, clozapine is commonly prescribed for severely disturbed BPD patients [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 9" title="Haw C, Stubbs J. Medication for borderline personality disorder: a survey at a secure hospital. Int J Psychiatry Clin Pract. 2011;15:280–5. doi:
 10.3109/13651501.2011.590211
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR9" id="ref-link-section-d338620504e541">9</a>], a controversial practice both because of its significant side-effect profile, including potentially fatal severe neutropenia, and an absence of supporting randomised controlled trials (RCTs). Two non-RCT studies found psychotic and depressive symptom-related and global functioning improvements among a subset of BPD-patients with prolonged and/or pronounced psychotic symptoms [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 10" title="Frankenberg FR, Zanarini MC. Clozapine treatment of borderline patients: a preliminary study. Compr Psychiatry. 1993;34:402–5." href="/articles/10.1186/s40479-016-0049-x#ref-CR10" id="ref-link-section-d338620504e544">10</a>, <a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 11" title="Benedetti F, Sforzini L, Colombo C, Maffei C, Smeraldi E. Low-dose clozapine in acute and continuation treatment of severe borderline personality disorder. J Clin Psychiatry. 1998;59:103–7." href="/articles/10.1186/s40479-016-0049-x#ref-CR11" id="ref-link-section-d338620504e547">11</a>]. One further study, our own recent retrospective case-series [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 12" title="Frogley C, Anagnostakis K, Mitchell S, Mason F, Taylor D, Dickens G, Picchioni MM. A case series of clozapine for borderline personality disorder. Ann Clin Psychiatry. 2013;25:125–34." href="/articles/10.1186/s40479-016-0049-x#ref-CR12" id="ref-link-section-d338620504e550">12</a>], suggested a number of objective benefits for women diagnosed with BPD displaying severe symptoms and resident in a secure mental health service. Despite this, there are currently no published studies of patients’ personal subjective experiences of taking clozapine for BPD. In this study we conducted semi-structured interviews with the same women participants to explore their personal experience of clozapine.</p></div></div></section><section data-title="Methods"><div class="c-article-section" id="Sec2-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Sec2">Methods</h2><div class="c-article-section__content" id="Sec2-content"><p>Inclusion criteria: women aged 18 to 65 diagnosed with BPD and treated with clozapine while inpatients at St Andrew’s Healthcare between 2002 and 2010. Exclusion criteria: learning disability, diagnosis of schizophrenia or other psychotic disorder. Consenting participants were interviewed for up to 1 h. The interview comprised items about clozapine initiation, and their experience of taking it. Emerging issues were explored through unscripted prompts and cues. Interviews were audio-recorded, transcribed and subjected to a six stage thematic analysis [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 13" title="Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3:77–101. 
 http://dx.doi.org/10.1191/1478088706qp063oa
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR13" id="ref-link-section-d338620504e561">13</a>]: i) transcripts were read repeatedly; ii) independent open coding of narrative data; iii) codes were compared, discussed, and, where necessary, amalgamated or split; iv) segments with similar codes were mapped; v) segments were linked hierarchically into sub-themes and combined into themes; vi) further recoding following review and discussion by the research team to ensure congruence between the presented extracts and each theme. Our guiding approach was essentialist-realist since we assumed that what participants told us reflected the reality as they saw it.</p></div></div></section><section data-title="Results"><div class="c-article-section" id="Sec3-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Sec3">Results</h2><div class="c-article-section__content" id="Sec3-content"><p>Thirty women were eligible and 20 agreed to participate (response rate 67 %). Mean age of participants at clozapine initiation was 27.8 years (SD = 7.8); mean time on clozapine was 26.5 months (SD = 23.0); 15 (75.0 %) patients were detained under forensic commitment at initiation and 5 (25.0 %) under civil commitment; almost all (<i>n</i> = 18, 90.0 %) had a history of previous admissions to secure services; all had received other antipsychotics prior to clozapine (Mode = 3; range 1 to 6). Analysis revealed four themes.</p><h3 class="c-article__sub-heading" id="Sec4">Evaluation</h3><p>Participants described an active personal evaluation of clozapine’s effects, expressed as a perceived benefit-loss trade-off. Benefits seemed profound but were not always articulated precisely:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“It’s just hard to explain the difference, because a lot of people have noticed the difference with me since I’ve been on it</i> [clozapine]<i>, but it’s hard to explain what it feels like inside”</i> (P15)</p> <p> <i>“I wish it had been around years ago. Literally, you know. It’s been really, really good, it’s been a really positive experience.”</i> (P8)</p> <p> <i>“… it closed my emotions off. It closed me off… I literally closed down. I can’t feel anything. I’m more like a robot not a woman.”</i> (P20)</p> </div></blockquote> <p>Most women mentioned significant side-effects, notably hypersalivation (<i>n</i> = 11 at 6 month follow-up). In addition, there was a mean weight gain of 7.8 Kg at 6 month follow-up. However, side effect importance appeared comparatively low within an overall positive evaluation of clozapine.</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“In the beginning I was very tired… but I’ve managed to pull myself out of that… which comes to the second point, which is becoming overweight. But I have had weight problems before I went on to clozapine, so it’s not solely dependent on clozapine. The clozapine hasn’t helped my weight at all. But I think it, erm, if it’s managed properly, I think you can control your weight with clozapine, you know, maybe some exercise”</i> (P8)</p> <p> <i>“The weight gain well I deal with that my way, that’s just an ongoing thing. I do things about that so it’s alright; it’s not the end of the world is it?”</i> (P20)</p> </div></blockquote> <p>Some participants drew positive comparisons between clozapine and other antipsychotics they had experienced, all in clozapine’s favour.</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“I was taking 40</i> [mg] <i>olanzapine a day… I was still struggling, I was still crying, still doing risk behaviours and everything. Since I got put on clozapine I’ve built it up slowly and I haven’t done anything since. I’ve tried loads of drugs, loads and loads of different ones but clozapine is best out of all of them”</i> (P18)</p> </div></blockquote> <h3 class="c-article__sub-heading" id="Sec5">Wellbeing</h3><p>Almost all (19/20) participants reported tangible benefits from taking prescribed clozapine including cognitive and affective changes:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“I’m not in turmoil anymore. I just see it as what will be will be and I am who I am…I deal with things a lot better, it doesn’t raise so many issues… I suppose my impulse control has gone down, my impulses have gone down”</i> (P16)</p> <p> <i>“I used to be like… climbing up the ceiling and then dropping really flat. That hasn’t happened since the clozapine”</i> (P19)</p> </div></blockquote> <p>Spontaneous comments of behavioural and social improvement were made by a substantial proportion of participants including reduced impulsivity and aggression/self-harm, and improved relationships. Where clozapine had commenced then stopped participants noted that the gains made were subsequently lost. One woman said that clozapine had negatively affected her impulsivity and interpersonal relationships. Some described becoming ‘normal’ while others described something more profound:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“I’ve always called it the magic pill because other medications have made me better…but they masked my illness. But with clozapine it’s not that it makes me better, it completely turns me into a normal person. It’s not masking something it takes it away”</i> (P2)</p> <p> <i>“it’s given me freedom of thought, speech…it’s made me well…made me happy. It’s made me someone that I’ve never been able to be before. I couldn’t hold a conversation like this years ago, I would have just been rude, obnoxious, scared…paranoid, self-harming every day, just like a shell of a person”</i> (P6)</p> </div></blockquote> <h3 class="c-article__sub-heading" id="Sec6">Understanding</h3><p>This theme encompassed women’s expressed understanding of BPD within a medical framework:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“Although we get the depressive thoughts, it isn’t actually clinical depression so for Borderlines</i> [sic] <i>it</i> [anti-depressant medication] <i>doesn’t work. So yeah, all the other medication I’ve been on obviously hasn’t helped me but in the last 18 months clozapine has really helped me”</i> (P7)</p> </div></blockquote> <p>Participant 3 understood her behaviour, which she described as “aggressive and lashing out” prior to clozapine initiation in illness-defined terms:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“Because I was really poorly. I had really poor behaviour, but not just because I wanted to be, but because I couldn’t be anything else”</i> </p> </div></blockquote> <p>Some also understood the effects of clozapine through observation of fellow patients:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“I asked to be put on it. Because I saw what it was like when the other girls here took it. I just said I wanted to go on it because it helps the other girls”</i> (P5)</p> </div></blockquote> <p>Participants sometimes came to new understanding of the change attributed to clozapine from feedback from others:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“One poor nurse, I don’t remember but I was told afterwards, she said she was scared of me. You don’t realise how you were before you are put on clozapine”</i> (P9)</p> </div></blockquote> <h3 class="c-article__sub-heading" id="Sec7">Self-management</h3><p>Central to self-management was the relationship with the prescribing psychiatrist who had recommended the medicine.</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“We sat down and they talked to me about my illness, which is Post Traumatic Stress Disorder and Borderline Personality Disorder, and that this medication worked really well in people with my condition, and that they had been using it for a while and that it’s been really good and they wanted to try me on it”</i> (P2)</p> </div></blockquote> <p>For some clozapine was viewed as the primary method by which they would continue to manage their BPD, while some expressed that clozapine facilitated other aspects of their care and treatment:</p><blockquote class="c-blockquote"><div class="c-blockquote__body"> <p> <i>“I wouldn’t ever stop taking it, put it that way. It’s annoying but I would never stop taking it”</i> (P19)</p> <p> <i>“I’m really stable and I’ve started applying the skills that we learn in DBT. If at times I get upset about anything or whatever, I can quickly bring myself back to, you know, dealing with things appropriately, rather than going completely off the rails… And I feel like I can feel the emotions that I feel but with the clozapine it helps me to do it in a more balanced way”</i> (P14)</p> </div></blockquote> </div></div></section><section data-title="Discussion"><div class="c-article-section" id="Sec8-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Sec8">Discussion</h2><div class="c-article-section__content" id="Sec8-content"><p>The largely positive results are consistent with our recent study [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 10" title="Frankenberg FR, Zanarini MC. Clozapine treatment of borderline patients: a preliminary study. Compr Psychiatry. 1993;34:402–5." href="/articles/10.1186/s40479-016-0049-x#ref-CR10" id="ref-link-section-d338620504e787">10</a>] and other non-RCT evidence [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 10" title="Frankenberg FR, Zanarini MC. Clozapine treatment of borderline patients: a preliminary study. Compr Psychiatry. 1993;34:402–5." href="/articles/10.1186/s40479-016-0049-x#ref-CR10" id="ref-link-section-d338620504e790">10</a>, <a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 11" title="Benedetti F, Sforzini L, Colombo C, Maffei C, Smeraldi E. Low-dose clozapine in acute and continuation treatment of severe borderline personality disorder. J Clin Psychiatry. 1998;59:103–7." href="/articles/10.1186/s40479-016-0049-x#ref-CR11" id="ref-link-section-d338620504e793">11</a>, <a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 14" title="Beri A, Boydell J. Clozapine in borderline personality disorder: a review of the evidence. Ann Clin Psychiatry. 2014;26:139–44." href="/articles/10.1186/s40479-016-0049-x#ref-CR14" id="ref-link-section-d338620504e796">14</a>]. They challenge a universal pharmacology-free BPD-recovery paradigm. Nevertheless, the congruence was unexpected since clozapine’s side-effect profile is so marked. Even serious disadvantages were described matter-of-factly, and the risks considered tolerable. Only psychosocial approaches are recommended for BPD. However, some people experience Dialectical Behaviour Therapy as too focused on self-harm, and less helpful for self-confidence, emotions and relatonships [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 15" title="Bateman A, Fonagy P. Mentalization based treatment for borderline personality disorder. World Psychiatry. 2010;9:11–5." href="/articles/10.1186/s40479-016-0049-x#ref-CR15" id="ref-link-section-d338620504e799">15</a>], the areas that women in this study reported the most progress on. In the absence of an RCT, many practitioners already prescribe clozapine for BPD off-licence [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 9" title="Haw C, Stubbs J. Medication for borderline personality disorder: a survey at a secure hospital. Int J Psychiatry Clin Pract. 2011;15:280–5. doi:
 10.3109/13651501.2011.590211
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR9" id="ref-link-section-d338620504e803">9</a>]. Their practice is increasingly evidence-based and, most importantly, valued by many patients. The results are also consistent with data that non-BPD patients prescribed antipsychotics are quick and decisive in their judgement of them as ‘good’ or ‘bad’ [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 16" title="Carrick R, Mitchell A, Powell RA, Lloyd K. The quest for well-being: a qualitative study of the experience of taking antipsychotic medication. Psychol Psychother. 2004;77:19–33. doi:
 10.1348/147608304322874236
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR16" id="ref-link-section-d338620504e806">16</a>]. To reduce reporting bias, interviews were conducted by an assistant psychologist who had no clinical role with the participants. The interview style encouraged reporting of all experiences, while confidentiality and anonymity were assured. We invited all eligible patients who had received clozapine for BPD to take part. It is possible that the one third who declined were less satisfied, though that does not negate the experiences of the other participants. The sample included many detained women with very complex needs. Clinicians should communicate clearly with BPD-diagnosed patients about clozapine treatment. People with BPD seem to be generally dissatisfied with medication-oriented approaches [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 16" title="Carrick R, Mitchell A, Powell RA, Lloyd K. The quest for well-being: a qualitative study of the experience of taking antipsychotic medication. Psychol Psychother. 2004;77:19–33. doi:
 10.1348/147608304322874236
 
 ." href="/articles/10.1186/s40479-016-0049-x#ref-CR16" id="ref-link-section-d338620504e809">16</a>]. However, it is premature to generalise findings from medicines in general to clozapine in particular. Participants were sanguine about their experience: this suggests that good communication with BPD patients around the reasons for prescribing clozapine is essential. Development in the US of a shared risk evaluation and mitigation strategy (REMS) called the Clozapine REMS Program which requires central monitoring of prescribing, dispensing, and receipt of clozapine should further increase confidence in the safety of the drug which may assist in aiding balanced decision+s about. In the absence of gold standard evidence this study and our related study [<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 12" title="Frogley C, Anagnostakis K, Mitchell S, Mason F, Taylor D, Dickens G, Picchioni MM. A case series of clozapine for borderline personality disorder. Ann Clin Psychiatry. 2013;25:125–34." href="/articles/10.1186/s40479-016-0049-x#ref-CR12" id="ref-link-section-d338620504e812">12</a>] suggests that therapeutic nihilism about this group should be challenged: severe cases of BPD can be treated successfully, women value the treatment, and tolerate inconvenience and side effects because the gains can be profound.</p><p>Finally, we cannot overstress the importance of the need for well-designed RCTs to rigorously test the efficacy of clozapineon all sub-syndromal symptoms of the disorder in people with moderate to severe BPD.</p></div></div></section> <section data-title="Abbreviations"><div class="c-article-section" id="abbreviations-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="abbreviations">Abbreviations</h2><div class="c-article-section__content" id="abbreviations-content"><dl class="c-abbreviation_list"><dt class="c-abbreviation_list__term u-text-bold u-float-left u-pr-16" style="min-width:50px;"><dfn>BPD:</dfn></dt><dd class="c-abbreviation_list__description u-mb-24"> <p>Borderline personality disorder</p> </dd><dt class="c-abbreviation_list__term u-text-bold u-float-left u-pr-16" style="min-width:50px;"><dfn>RCT:</dfn></dt><dd class="c-abbreviation_list__description u-mb-24"> <p>Randomised controlled trial</p> </dd></dl></div></div></section><div id="MagazineFulltextArticleBodySuffix"><section aria-labelledby="Bib1" data-title="References"><div class="c-article-section" id="Bib1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Bib1">References</h2><div class="c-article-section__content" id="Bib1-content"><div data-container-section="references"><ol class="c-article-references" data-track-component="outbound reference" data-track-context="references section"><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="1."><p class="c-article-references__text" id="ref-CR1">Lieb K, Zanarini MC, Schmahl C, Linehan MM, Bohus PM. Borderline personality disorder. Lancet. 2004;364:453–61. doi:<a href="https://doi.org/10.1016/S0140-6736(04)16770-6" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.1016/S0140-6736(04)16770-6">10.1016/S0140-6736(04)16770-6</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0140-6736(04)16770-6" data-track-item_id="10.1016/S0140-6736(04)16770-6" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0140-6736%2804%2916770-6" aria-label="Article reference 1" data-doi="10.1016/S0140-6736(04)16770-6">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15288745" aria-label="PubMed reference 1">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 1" href="http://scholar.google.com/scholar_lookup?&title=Borderline%20personality%20disorder&journal=Lancet&doi=10.1016%2FS0140-6736%2804%2916770-6&volume=364&pages=453-61&publication_year=2004&author=Lieb%2CK&author=Zanarini%2CMC&author=Schmahl%2CC&author=Linehan%2CMM&author=Bohus%2CPM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="2."><p class="c-article-references__text" id="ref-CR2">Elisei S, Verdolini N, Anastasi S. Suicidal attempts among emergency department patients: one-year of clinical experience. Psychiat Danub. 2012;24 Suppl 1:140–2.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 2" href="http://scholar.google.com/scholar_lookup?&title=Suicidal%20attempts%20among%20emergency%20department%20patients%3A%20one-year%20of%20clinical%20experience&journal=Psychiat%20Danub&volume=24&issue=Suppl%201&pages=140-2&publication_year=2012&author=Elisei%2CS&author=Verdolini%2CN&author=Anastasi%2CS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="3."><p class="c-article-references__text" id="ref-CR3">Comtois KA, Carmel A. Borderline personality disorder and high utilization of inpatient psychiatric hospitalization: concordance between research and clinical diagnosis. J Behav Health Ser R. 2016;43:272–80. doi:<a href="https://doi.org/10.1007/s11414-014-9416-9" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.1007/s11414-014-9416-9">10.1007/s11414-014-9416-9</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s11414-014-9416-9" data-track-item_id="10.1007/s11414-014-9416-9" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s11414-014-9416-9" aria-label="Article reference 3" data-doi="10.1007/s11414-014-9416-9">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 3" href="http://scholar.google.com/scholar_lookup?&title=Borderline%20personality%20disorder%20and%20high%20utilization%20of%20inpatient%20psychiatric%20hospitalization%3A%20concordance%20between%20research%20and%20clinical%20diagnosis&journal=J%20Behav%20Health%20Ser%20R&doi=10.1007%2Fs11414-014-9416-9&volume=43&pages=272-80&publication_year=2016&author=Comtois%2CKA&author=Carmel%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="4."><p class="c-article-references__text" id="ref-CR4">Hayashi N, Igarashi M, Imai A, Osawa Y, Utsumi K, Ishikawa Y, et al. Psychiatric disorders and clinical correlates of suicidal patients admitted to a psychiatric hospital in Tokyo. BMC Psychiat. 2010;10:109. doi:<a href="https://doi.org/10.1186/1471-244X-10-109" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.1186/1471-244X-10-109">10.1186/1471-244X-10-109</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1186/1471-244X-10-109" data-track-item_id="10.1186/1471-244X-10-109" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1186/1471-244X-10-109" aria-label="Article reference 4" data-doi="10.1186/1471-244X-10-109">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 4" href="http://scholar.google.com/scholar_lookup?&title=Psychiatric%20disorders%20and%20clinical%20correlates%20of%20suicidal%20patients%20admitted%20to%20a%20psychiatric%20hospital%20in%20Tokyo&journal=BMC%20Psychiat&doi=10.1186%2F1471-244X-10-109&volume=10&publication_year=2010&author=Hayashi%2CN&author=Igarashi%2CM&author=Imai%2CA&author=Osawa%2CY&author=Utsumi%2CK&author=Ishikawa%2CY"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="5."><p class="c-article-references__text" id="ref-CR5">Latalova K, Prasko J. Aggression in borderline personality disorder. Psychiat Quart. 2010;81:239–51. doi:<a href="https://doi.org/10.1007/s11126-010-9133-3" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.1007/s11126-010-9133-3">10.1007/s11126-010-9133-3</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="noopener" data-track-label="10.1007/s11126-010-9133-3" data-track-item_id="10.1007/s11126-010-9133-3" data-track-value="article reference" data-track-action="article reference" href="https://link.springer.com/doi/10.1007/s11126-010-9133-3" aria-label="Article reference 5" data-doi="10.1007/s11126-010-9133-3">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BC3cjnsF2qtA%3D%3D" aria-label="CAS reference 5">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20390357" aria-label="PubMed reference 5">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 5" href="http://scholar.google.com/scholar_lookup?&title=Aggression%20in%20borderline%20personality%20disorder&journal=Psychiat%20Quart&doi=10.1007%2Fs11126-010-9133-3&volume=81&pages=239-51&publication_year=2010&author=Latalova%2CK&author=Prasko%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="6."><p class="c-article-references__text" id="ref-CR6">Katsakou C, Marougka S, Barnicot K, Savill M, White H, Lockwood K, Priebe S. Recovery in borderline personality disorder: a qualitative study of service users’ perspectives. PLoS ONE. 2012;7(5). <a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036517" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036517">http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036517</a>.</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="7."><p class="c-article-references__text" id="ref-CR7">National Collaborating Centre for Mental Health (UK). Borderline personality disorder: treatment and management. (No. 78). Leicester: British Psychological Society; 2012.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 7" href="http://scholar.google.com/scholar_lookup?&title=Borderline%20personality%20disorder%3A%20treatment%20and%20management.%20%28No.%2078%29&publication_year=2012"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="8."><p class="c-article-references__text" id="ref-CR8">Shearin EN, Linehan MM. Dialectical behavior therapy for borderline personality disorder: theoretical and empirical foundations. Acta Psychiat Scand. 1994;89 Supplement s379:61–8. doi:<a href="https://doi.org/10.1111/j.1600-0447.1994.tb05820.x" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.1111/j.1600-0447.1994.tb05820.x">10.1111/j.1600-0447.1994.tb05820.x</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1600-0447.1994.tb05820.x" data-track-item_id="10.1111/j.1600-0447.1994.tb05820.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1600-0447.1994.tb05820.x" aria-label="Article reference 8" data-doi="10.1111/j.1600-0447.1994.tb05820.x">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 8" href="http://scholar.google.com/scholar_lookup?&title=Dialectical%20behavior%20therapy%20for%20borderline%20personality%20disorder%3A%20theoretical%20and%20empirical%20foundations&journal=Acta%20Psychiat%20Scand&doi=10.1111%2Fj.1600-0447.1994.tb05820.x&volume=89%20Supplement%20s379&pages=61-8&publication_year=1994&author=Shearin%2CEN&author=Linehan%2CMM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="9."><p class="c-article-references__text" id="ref-CR9">Haw C, Stubbs J. Medication for borderline personality disorder: a survey at a secure hospital. Int J Psychiatry Clin Pract. 2011;15:280–5. doi:<a href="https://doi.org/10.3109/13651501.2011.590211" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.3109/13651501.2011.590211">10.3109/13651501.2011.590211</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3109/13651501.2011.590211" data-track-item_id="10.3109/13651501.2011.590211" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3109%2F13651501.2011.590211" aria-label="Article reference 9" data-doi="10.3109/13651501.2011.590211">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22122000" aria-label="PubMed reference 9">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 9" href="http://scholar.google.com/scholar_lookup?&title=Medication%20for%20borderline%20personality%20disorder%3A%20a%20survey%20at%20a%20secure%20hospital&journal=Int%20J%20Psychiatry%20Clin%20Pract&doi=10.3109%2F13651501.2011.590211&volume=15&pages=280-5&publication_year=2011&author=Haw%2CC&author=Stubbs%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="10."><p class="c-article-references__text" id="ref-CR10">Frankenberg FR, Zanarini MC. Clozapine treatment of borderline patients: a preliminary study. Compr Psychiatry. 1993;34:402–5.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0010-440X(93)90065-C" data-track-item_id="10.1016/0010-440X(93)90065-C" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0010-440X%2893%2990065-C" aria-label="Article reference 10" data-doi="10.1016/0010-440X(93)90065-C">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 10" href="http://scholar.google.com/scholar_lookup?&title=Clozapine%20treatment%20of%20borderline%20patients%3A%20a%20preliminary%20study&journal=Compr%20Psychiatry&doi=10.1016%2F0010-440X%2893%2990065-C&volume=34&pages=402-5&publication_year=1993&author=Frankenberg%2CFR&author=Zanarini%2CMC"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="11."><p class="c-article-references__text" id="ref-CR11">Benedetti F, Sforzini L, Colombo C, Maffei C, Smeraldi E. Low-dose clozapine in acute and continuation treatment of severe borderline personality disorder. J Clin Psychiatry. 1998;59:103–7.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.4088/JCP.v59n0302" data-track-item_id="10.4088/JCP.v59n0302" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.4088%2FJCP.v59n0302" aria-label="Article reference 11" data-doi="10.4088/JCP.v59n0302">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK1cXisVOqsrc%3D" aria-label="CAS reference 11">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9541151" aria-label="PubMed reference 11">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 11" href="http://scholar.google.com/scholar_lookup?&title=Low-dose%20clozapine%20in%20acute%20and%20continuation%20treatment%20of%20severe%20borderline%20personality%20disorder&journal=J%20Clin%20Psychiatry&doi=10.4088%2FJCP.v59n0302&volume=59&pages=103-7&publication_year=1998&author=Benedetti%2CF&author=Sforzini%2CL&author=Colombo%2CC&author=Maffei%2CC&author=Smeraldi%2CE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="12."><p class="c-article-references__text" id="ref-CR12">Frogley C, Anagnostakis K, Mitchell S, Mason F, Taylor D, Dickens G, Picchioni MM. A case series of clozapine for borderline personality disorder. Ann Clin Psychiatry. 2013;25:125–34.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23638443" aria-label="PubMed reference 12">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 12" href="http://scholar.google.com/scholar_lookup?&title=A%20case%20series%20of%20clozapine%20for%20borderline%20personality%20disorder&journal=Ann%20Clin%20Psychiatry&volume=25&pages=125-134&publication_year=2013&author=Frogley%2CC&author=Anagnostakis%2CK&author=Mitchell%2CS&author=Mason%2CF&author=Taylor%2CD&author=Dickens%2CG&author=Picchioni%2CMM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="13."><p class="c-article-references__text" id="ref-CR13">Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3:77–101. <a href="http://dx.doi.org/10.1191/1478088706qp063oa" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="http://dx.doi.org/10.1191/1478088706qp063oa">http://dx.doi.org/10.1191/1478088706qp063oa</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1191/1478088706qp063oa" data-track-item_id="10.1191/1478088706qp063oa" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1191%2F1478088706qp063oa" aria-label="Article reference 13" data-doi="10.1191/1478088706qp063oa">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 13" href="http://scholar.google.com/scholar_lookup?&title=Using%20thematic%20analysis%20in%20psychology&journal=Qual%20Res%20Psychol&doi=10.1191%2F1478088706qp063oa&volume=3&pages=77-101&publication_year=2006&author=Braun%2CV&author=Clarke%2CV"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="14."><p class="c-article-references__text" id="ref-CR14">Beri A, Boydell J. Clozapine in borderline personality disorder: a review of the evidence. Ann Clin Psychiatry. 2014;26:139–44.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24812651" aria-label="PubMed reference 14">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 14" href="http://scholar.google.com/scholar_lookup?&title=Clozapine%20in%20borderline%20personality%20disorder%3A%20a%20review%20of%20the%20evidence&journal=Ann%20Clin%20Psychiatry&volume=26&pages=139-44&publication_year=2014&author=Beri%2CA&author=Boydell%2CJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="15."><p class="c-article-references__text" id="ref-CR15">Bateman A, Fonagy P. Mentalization based treatment for borderline personality disorder. World Psychiatry. 2010;9:11–5.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/j.2051-5545.2010.tb00255.x" data-track-item_id="10.1002/j.2051-5545.2010.tb00255.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fj.2051-5545.2010.tb00255.x" aria-label="Article reference 15" data-doi="10.1002/j.2051-5545.2010.tb00255.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20148147" aria-label="PubMed reference 15">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816926" aria-label="PubMed Central reference 15">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 15" href="http://scholar.google.com/scholar_lookup?&title=Mentalization%20based%20treatment%20for%20borderline%20personality%20disorder&journal=World%20Psychiatry&doi=10.1002%2Fj.2051-5545.2010.tb00255.x&volume=9&pages=11-5&publication_year=2010&author=Bateman%2CA&author=Fonagy%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="16."><p class="c-article-references__text" id="ref-CR16">Carrick R, Mitchell A, Powell RA, Lloyd K. The quest for well-being: a qualitative study of the experience of taking antipsychotic medication. Psychol Psychother. 2004;77:19–33. doi:<a href="https://doi.org/10.1348/147608304322874236" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.1348/147608304322874236">10.1348/147608304322874236</a>.</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1348/147608304322874236" data-track-item_id="10.1348/147608304322874236" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1348%2F147608304322874236" aria-label="Article reference 16" data-doi="10.1348/147608304322874236">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15025902" aria-label="PubMed reference 16">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 16" href="http://scholar.google.com/scholar_lookup?&title=The%20quest%20for%20well-being%3A%20a%20qualitative%20study%20of%20the%20experience%20of%20taking%20antipsychotic%20medication&journal=Psychol%20Psychother&doi=10.1348%2F147608304322874236&volume=77&pages=19-33&publication_year=2004&author=Carrick%2CR&author=Mitchell%2CA&author=Powell%2CRA&author=Lloyd%2CK"> Google Scholar</a> </p></li></ol><p class="c-article-references__download u-hide-print"><a data-track="click" data-track-action="download citation references" data-track-label="link" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1186/s40479-016-0049-x?format=refman&flavour=references">Download references<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p></div></div></div></section></div><section data-title="Acknowledgements"><div class="c-article-section" id="Ack1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Ack1">Acknowledgements</h2><div class="c-article-section__content" id="Ack1-content"><p>Not applicable.</p> <h3 class="c-article__sub-heading" id="FPar1">Funding</h3> <p>The study was funded by St Andrew’s Healthcare. The funding body played no role in the design of the study and collection, analysis and interpretation of data.</p> <h3 class="c-article__sub-heading" id="FPar2">Availability of data and materials</h3> <p>The datasets during and/or analysed during the current study available from the corresponding author on reasonable request.</p> <h3 class="c-article__sub-heading" id="FPar3">Authors’ contributions</h3> <p>GLD conceived and designed the study, analysed and interpreted the patient data, and wrote the manuscript. CF collected the data and made a substantial contribution to data analysis. FM made a substantial conclusion to conception and design of the study. KA made a substantial contribution to conception and design of the study. MMP conceived and designed the study and was a major contributor in writing the manuscript. All authors read and approved the final manuscript.</p> <h3 class="c-article__sub-heading" id="FPar4">Competing interests</h3> <p>The authors declare that they have no competing interests.</p> <h3 class="c-article__sub-heading" id="FPar5">Consent for publication</h3> <p>No identifiable individual data is presented. All participants consented to anonymised quotes to be used.</p> <h3 class="c-article__sub-heading" id="FPar6">Ethics approval and consent to participate</h3> <p>The study was approved by East Midlands NHS Research Ethics Committee Research Ethics Committee (ref: 11/EM0042). All participants gave written, informed consent.</p> </div></div></section><section aria-labelledby="author-information" data-title="Author information"><div class="c-article-section" id="author-information-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="author-information">Author information</h2><div class="c-article-section__content" id="author-information-content"><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Division of Mental Health Nursing and Counselling, School of Social and Health Sciences, Abertay University, Bell Street, Dundee, DD1 1HG, UK</p><p class="c-article-author-affiliation__authors-list">Geoffrey L. Dickens</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">St Andrew’s Academic Centre, Northampton, NN1 5DG, UK</p><p class="c-article-author-affiliation__authors-list">Catherine Frogley, Fiona Mason, Katina Anagnostakis & Marco M. Picchioni</p></li><li id="Aff3"><p class="c-article-author-affiliation__address">School of Psychology, Faculty of Arts and Human Sciences, AD Building, University of Surrey, Guildford, Surrey, GU2 7XH, UK</p><p class="c-article-author-affiliation__authors-list">Catherine Frogley</p></li><li id="Aff4"><p class="c-article-author-affiliation__address">Medical School, University of Buckingham, Yeomanry House, Hunter Street, Buckingham, MK18 1EG, UK</p><p class="c-article-author-affiliation__authors-list">Fiona Mason</p></li><li id="Aff5"><p class="c-article-author-affiliation__address">Department of Forensic and Neurodevelopmental Science, King’s College London Institute of Psychiatry Psychology and Neuroscience, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK</p><p class="c-article-author-affiliation__authors-list">Marco M. Picchioni</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-Geoffrey_L_-Dickens-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">Geoffrey L. 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Dickens</a>.</p></div></div></section><section data-title="Rights and permissions"><div class="c-article-section" id="rightslink-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="rightslink">Rights and permissions</h2><div class="c-article-section__content" id="rightslink-content"> <p> <b>Open Access</b> This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<a href="http://creativecommons.org/licenses/by/4.0/" rel="license">http://creativecommons.org/licenses/by/4.0/</a>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. 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id="citeas">Cite this article</h3><p class="c-bibliographic-information__citation">Dickens, G.L., Frogley, C., Mason, F. <i>et al.</i> Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder. <i>bord personal disord emot dysregul</i> <b>3</b>, 12 (2016). https://doi.org/10.1186/s40479-016-0049-x</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1186/s40479-016-0049-x?format=refman&flavour=citation">Download citation<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p><ul class="c-bibliographic-information__list" data-test="publication-history"><li class="c-bibliographic-information__list-item"><p>Received<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2016-07-18">18 July 2016</time></span></p></li><li class="c-bibliographic-information__list-item"><p>Accepted<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2016-10-01">01 October 2016</time></span></p></li><li class="c-bibliographic-information__list-item"><p>Published<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2016-10-07">07 October 2016</time></span></p></li><li class="c-bibliographic-information__list-item c-bibliographic-information__list-item--full-width"><p><abbr title="Digital Object Identifier">DOI</abbr><span class="u-hide">: </span><span class="c-bibliographic-information__value">https://doi.org/10.1186/s40479-016-0049-x</span></p></li></ul><div data-component="share-box"><div class="c-article-share-box u-display-none" 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href="/search?query=Emotionally%20unstable%20personality%20disorder&facet-discipline="Medicine%20%26%20Public%20Health"" data-track="click" data-track-action="view keyword" data-track-label="link">Emotionally unstable personality disorder</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=Thematic%20analysis&facet-discipline="Medicine%20%26%20Public%20Health"" data-track="click" data-track-action="view keyword" data-track-label="link">Thematic analysis</a></span></li></ul><div data-component="article-info-list"></div></div></div></div></div></section> </article> </main> <div class="c-article-extras u-text-sm u-hide-print" data-container-type="reading-companion" data-track-component="reading companion"> <aside> <div data-test="download-article-link-wrapper" class="js-context-bar-sticky-point-desktop" data-track-context="reading companion"> <div class="c-pdf-download u-clear-both"> <a 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