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class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/JananiRavi23">Janani Ravi</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/EddaKlipp"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/EddaKlipp">Edda Klipp</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/IwonaFijalkowska"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div 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class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="300557083" href="https://www.academia.edu/Documents/in/Mathematics"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/xiaojingyang13","location":"/xiaojingyang13","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/xiaojingyang13","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Mathematics"]}" data-trace="false" data-dom-id="Pill-react-component-a37f90b5-e0cf-4ebe-a961-b361116264c6"></div> <div id="Pill-react-component-a37f90b5-e0cf-4ebe-a961-b361116264c6"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by xiaojing yang</h3></div><div class="js-work-strip profile--work_container" data-work-id="114001254"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001254/Robust_switch_like_destruction_of_the_CDK_inhibitor_Sic1_is_ensured_by_a_double_negative_feedback_loop"><img alt="Research paper thumbnail of Robust switch-like destruction of the CDK inhibitor Sic1 is ensured by a double negative feedback loop" class="work-thumbnail" src="https://attachments.academia-assets.com/110815094/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001254/Robust_switch_like_destruction_of_the_CDK_inhibitor_Sic1_is_ensured_by_a_double_negative_feedback_loop">Robust switch-like destruction of the CDK inhibitor Sic1 is ensured by a double negative feedback loop</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In eukaryotic cell division cycles, the initiation of DNA replication (S-phase entry) is driven b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In eukaryotic cell division cycles, the initiation of DNA replication (S-phase entry) is driven by a sharp rise in the activity of the S-phase cyclin-Cdk. A critical step leading to this G1/S transition in yeast is the rapid proteolytic degradation of the S-phase cyclin (Clb5/6)-Cdk stoichiometric inhibitor Sic1. Multisite phosphorylation by G1 cyclin (Cln)-Cdk is thought to be responsible for Sic1's switchlike destruction. Here, by monitoring Sic1 degradation in real time in individual cells, we show that it is the double-negative feedback loop between Clb5/6-Cdk and Sic1, not Cln-Cdk, that ensures a robust rapid destruction of Sic1 against genetic and environmental perturbations. Our study establishes a new understanding on the control mechanism of G1/S progression and provides insights in the coordination of cell cycle transitions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="82a3a7cc574639df2dcae265a15e4a64" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815094,"asset_id":114001254,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815094/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001254"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001254"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001254; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001254]").text(description); $(".js-view-count[data-work-id=114001254]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001254; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001254']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001253"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001253/Structure_of_the_response_regulator_RPA3017_involved_in_red_light_signaling_in_Rhodopseudomonas_palustris"><img alt="Research paper thumbnail of Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris" class="work-thumbnail" src="https://attachments.academia-assets.com/110815103/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001253/Structure_of_the_response_regulator_RPA3017_involved_in_red_light_signaling_in_Rhodopseudomonas_palustris">Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris</a></div><div class="wp-workCard_item"><span>Acta crystallographica. Section F, Structural biology communications</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Two-component signal transduction is the major signaling mechanism that enables bacteria to survi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Two-component signal transduction is the major signaling mechanism that enables bacteria to survive and thrive in complex environmental conditions. The photosynthetic bacterium R. palustris employs two tandem bacteriophytochromes, RpBphP2 and RpBphP3, to perceive red-light signals that regulate the synthesis of light-harvesting complexes under low-light conditions. Both RpBphP2 and RpBphP3 are photosensory histidine kinases coupled to the same response regulator RPA3017. Together, they constitute a two-component system that converts a red-light signal into a biological signal. In this work, the crystal structure of RPA3017 in the unphosphorylated form at 1.9 Å resolution is presented. This structure reveals a tightly associated dimer arrangement that is conserved among phytochrome-related response regulators. The conserved active-site architecture provides structural insight into the phosphotransfer reaction between RpBphP2/RpBphP3 and RPA3017. Based on structural comparisons and ho...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="68f58f64c4d0fefb86c007e53b3abd85" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815103,"asset_id":114001253,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815103/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001253"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001253"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001253; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001253]").text(description); $(".js-view-count[data-work-id=114001253]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001253; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001253']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "68f58f64c4d0fefb86c007e53b3abd85" } } $('.js-work-strip[data-work-id=114001253]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001253,"title":"Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris","internal_url":"https://www.academia.edu/114001253/Structure_of_the_response_regulator_RPA3017_involved_in_red_light_signaling_in_Rhodopseudomonas_palustris","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815103,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815103/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/110815103/download_file","bulk_download_file_name":"Structure_of_the_response_regulator_RPA3.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815103/ptpmcrender-libre.pdf?1706152072=\u0026response-content-disposition=attachment%3B+filename%3DStructure_of_the_response_regulator_RPA3.pdf\u0026Expires=1741342416\u0026Signature=FGe9eYhyiKu6M5bemMtMnCiQQU~3~K523e~~zwjJQ2aLjMzKmOwTCvso3wEyiPYyz8VIfz~0xvx2hAhWglZEZ0nroLtLXwE9u02R6JtYp7k5c~F4SoKgFRn8DVb~R9l5ZizO5pTReX5jgpfGx484rbCUY~3z4j0bSgRAeMSgEHy3PssG4TH2OPV1rb9qmnUiSCtfYSnurjKK-JF9t2Wls-Q49y1qDm5cnE8vdQO7ilSSGTQKDSMXQolYQm9BVkjbfm9DpP0eZPeGH0uqdVoalpIrWhu9CwF~akvpP4EJ0PFkPHUYms4VZNTF7NJwsTTpO4flMUsndEOSHMzgM24QTA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001252"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001252/Intravenous_injection_of_microvesicle_delivery_miR_130b_alleviates_high_fat_diet_induced_obesity_in_C57BL_6_mice_through_translational_repression_of_PPAR_%CE%B3"><img alt="Research paper thumbnail of Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ" class="work-thumbnail" src="https://attachments.academia-assets.com/110815095/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001252/Intravenous_injection_of_microvesicle_delivery_miR_130b_alleviates_high_fat_diet_induced_obesity_in_C57BL_6_mice_through_translational_repression_of_PPAR_%CE%B3">Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ</a></div><div class="wp-workCard_item"><span>Journal of biomedical science</span><span>, Jan 16, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to targe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat deposition and glucose homeostasis remains unknown. Three-week-old C57BL/6 mice were fed a high-fat diet for 8 weeks and then intravenously injected with MV-packaged scrambled control microRNA (miRNA) or miR-130b every other day for 10 days. Glucose tolerance test was performed and body weight, epididymal fat weight, as well as the expression of lipid metabolic genes were determined. We showed that mice fed on high-fat diet for 8 weeks demonstrated significantly higher body weight, elevated blood glucose and impaired glucose tolerance. miR-130b-MV injection significantly reduced body weight and epididymal fat weight and partly restored glucose tolerance. miR-130b expression was significantly increased in the epididymal fat after miR-130b-MV injection while the protein content ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a5c264410a6f06c09239a9724576721" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815095,"asset_id":114001252,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815095/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001252"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001252"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001252; 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</script> <div class="js-work-strip profile--work_container" data-work-id="114001249"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001249/Controllable_synthesis_and_characterization_of_porous_FeVO4_nanorods_and_nanoparticles"><img alt="Research paper thumbnail of Controllable synthesis and characterization of porous FeVO4 nanorods and nanoparticles" class="work-thumbnail" src="https://attachments.academia-assets.com/110815088/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001249/Controllable_synthesis_and_characterization_of_porous_FeVO4_nanorods_and_nanoparticles">Controllable synthesis and characterization of porous FeVO4 nanorods and nanoparticles</a></div><div class="wp-workCard_item"><span>CrystEngComm</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fe 3 O 4 /Au composite nanoparticles (GoldMag NPs) have received considerable attention because o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fe 3 O 4 /Au composite nanoparticles (GoldMag NPs) have received considerable attention because of their advantageous properties arisen from both individual Au and Fe 3 O 4 nanoparticles. Many efforts have been devoted to the synthesis of these composite nanoparticles. Herein, GoldMag NPs were reported to be synthesized by two-step method. Fe 3 O 4 nanoparticles were prepared by co-precipitation and modified by the citric acid, and then citric acid-coated Fe 3 O 4 nanoparticles were used as seeds in sodium citrate solution to reduce the HAuCl 4. The size of obtained nanoparticles was geared from 25 to 300 nm by controlling the concentration of reactants. The GoldMag NPs were characterized by UV-vis spectrometer, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). The GoldMag NPs showed good superparamagnetism at room temperature and were well dispersed in water with surface plasmon resonance absorption peak varied from 538 nm to 570 nm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b0836ad11bed0819d3b6244eddeaa8c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815088,"asset_id":114001249,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815088/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001249"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001249"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001249; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001248"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001248/Light_signaling_mechanism_of_two_tandem_bacteriophytochromes"><img alt="Research paper thumbnail of Light signaling mechanism of two tandem bacteriophytochromes" class="work-thumbnail" src="https://attachments.academia-assets.com/110815090/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001248/Light_signaling_mechanism_of_two_tandem_bacteriophytochromes">Light signaling mechanism of two tandem bacteriophytochromes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highlights d RpBphP2 and RpBphP3 adopt similar tertiary structures but different dimer scaffolds ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highlights d RpBphP2 and RpBphP3 adopt similar tertiary structures but different dimer scaffolds d Residues at the GAF-PHY interface modulate photoconversion properties d A single mutation (T480P) in RpBphP3 enables canonical photoconversion d Angular orientation between PHY and HK domains is crucial for long-range signaling</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="56a107d975b73a5f8d206e32bcfe3ebc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815090,"asset_id":114001248,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815090/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001248"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001248"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001248; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001247"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001247/Direct_electrochemistry_and_electrocatalysis_of_hemoglobin_at_three_dimensional_gold_film_electrode_modified_with_self_assembled_monolayers_of_3_mercaptopropylphosphonic_acid"><img alt="Research paper thumbnail of Direct electrochemistry and electrocatalysis of hemoglobin at three-dimensional gold film electrode modified with self-assembled monolayers of 3-mercaptopropylphosphonic acid" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001247/Direct_electrochemistry_and_electrocatalysis_of_hemoglobin_at_three_dimensional_gold_film_electrode_modified_with_self_assembled_monolayers_of_3_mercaptopropylphosphonic_acid">Direct electrochemistry and electrocatalysis of hemoglobin at three-dimensional gold film electrode modified with self-assembled monolayers of 3-mercaptopropylphosphonic acid</a></div><div class="wp-workCard_item"><span>Analytica Chimica Acta</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Multilayered hemoglobin (Hb) molecules were successfully immobilized on three-dimensional gold fi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Multilayered hemoglobin (Hb) molecules were successfully immobilized on three-dimensional gold film electrode modified with self-assembled monolayers (SAMs) of 3-mercaptopropylphosphonic acid. Direct electrochemistry of the immobilized multilayered Hb occurs with high thermal stability and electrochemical stability. In the multilayered Hb film, the most inner Hb molecules can directly transfer electron with the electrode, while the Hb protein beyond this layer communicates</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001247"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001247"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001247; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001247]").text(description); $(".js-view-count[data-work-id=114001247]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001247; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001247']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001246"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001246/YfiT_from_Bacillus_subtilis_is_a_probable_metal_dependent_hydrolase_with_an_unusual_four_helix_bundle_topology"><img alt="Research paper thumbnail of YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001246/YfiT_from_Bacillus_subtilis_is_a_probable_metal_dependent_hydrolase_with_an_unusual_four_helix_bundle_topology">YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology</a></div><div class="wp-workCard_item"><span>Biochemistry</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">YfiT, a 19-kDa polypeptide from Bacillus subtilis, belongs to a small sequence family with member...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">YfiT, a 19-kDa polypeptide from Bacillus subtilis, belongs to a small sequence family with members predominantly from Gram positive bacteria. We have determined the crystal structure of YfiT in complex with Ni(2+) to a resolution of 1.7 A. YfiT exists as a dimer and binds Ni(2+) in a 1:1 stoichiometry. The protein has an unusual four-helix bundle topology and coordinates Ni(2+) in an octahedral geometry with three conserved histidines and three waters. Although there is no similarity in their overall structures, the coordination geometry of the metal and the residues that constitute the putative active site in YfiT are similar to those of metalloproteases such as thermolysin. Our structural analyses suggest that YfiT might function as a metal-dependent hydrolase.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001246"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001246"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001246; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001246]").text(description); 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</script> <div class="js-work-strip profile--work_container" data-work-id="114001245"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001245/Recombinant_Hamster_Oviductin_Is_Biologically_Active_and_Exerts_Positive_Effects_on_Sperm_Functions_and_Sperm_Oocyte_Binding"><img alt="Research paper thumbnail of Recombinant Hamster Oviductin Is Biologically Active and Exerts Positive Effects on Sperm Functions and Sperm-Oocyte Binding" class="work-thumbnail" src="https://attachments.academia-assets.com/110815113/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001245/Recombinant_Hamster_Oviductin_Is_Biologically_Active_and_Exerts_Positive_Effects_on_Sperm_Functions_and_Sperm_Oocyte_Binding">Recombinant Hamster Oviductin Is Biologically Active and Exerts Positive Effects on Sperm Functions and Sperm-Oocyte Binding</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Studies carried out in several mammalian species suggest that oviductin, also known as oviduct-sp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Studies carried out in several mammalian species suggest that oviductin, also known as oviduct-specific glycoprotein or OVGP1, plays a key role in sperm capacitation, fertilization, and development of early embryos. In the present study, we used recombinant DNA technology to produce, for the first time, recombinant hamster OVGP1 (rHamOVGP1) in human embryonic kidney 293 (HEK293) cells. rHamOVGP1 secreted in the culture medium was purified by affinity chromatography. The resulting protein migrated as a poly-dispersed band of 160-350 kDa on SDS-PAGE corresponding to the molecular mass of the native HamOVGP1. Subsequent mass spectrometric analysis of the purified rHamOVGP1 confirmed its identity as HamOVGP1. Immunocytochemistry demonstrated binding of rHamOVGP1 to the mid-piece and head of hamster sperm and to the zona pellucida (ZP) of ovarian oocytes. In vitro functional experiments showed that addition of rHamOVGP1 in the capacitation medium further enhanced tyrosine phosphorylation...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="20945ac7e7b291e69a74459d6b1d0c95" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815113,"asset_id":114001245,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815113/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001245"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001245"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001245; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001244"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001244/Biliproteins_and_their_Applications_in_Bioimaging"><img alt="Research paper thumbnail of Biliproteins and their Applications in Bioimaging" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001244/Biliproteins_and_their_Applications_in_Bioimaging">Biliproteins and their Applications in Bioimaging</a></div><div class="wp-workCard_item"><span>Procedia Chemistry</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001244"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001244"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001244; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001244]").text(description); $(".js-view-count[data-work-id=114001244]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001244; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001244']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114001244]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001244,"title":"Biliproteins and their Applications in Bioimaging","internal_url":"https://www.academia.edu/114001244/Biliproteins_and_their_Applications_in_Bioimaging","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001243"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001243/Biosynthesis_of_mucin_type_O_glycans_lack_of_correlation_between_glycosyltransferase_and_sulfotransferase_activities_and_CFTR_expression"><img alt="Research paper thumbnail of Biosynthesis of mucin type O-glycans: lack of correlation between glycosyltransferase and sulfotransferase activities and CFTR expression" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001243/Biosynthesis_of_mucin_type_O_glycans_lack_of_correlation_between_glycosyltransferase_and_sulfotransferase_activities_and_CFTR_expression">Biosynthesis of mucin type O-glycans: lack of correlation between glycosyltransferase and sulfotransferase activities and CFTR expression</a></div><div class="wp-workCard_item"><span>Glycoconjugate journal</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Structural differences have been reported in the glycosylation patterns of cystic fibrosis glycop...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Structural differences have been reported in the glycosylation patterns of cystic fibrosis glycoproteins. Although the gene mutated in cystic fibrosis (CFTR) has been cloned and characterized as a chloride channel, its relationship to the highly viscous mucus and structural glycoprotein and mucin abnormalities in cystic fibrosis still remains to be defined. We have evaluated O-glycan biosynthesis in CHO and BHK cells that express CFTR and DeltaF508 CFTR as in vitro models, and utilized the cftr knockout mouse as an in vivo model of CFTR dysfunction. Activities of glycosyltransferases and sulfotransferases synthesizing mucin type O-glycan chains were determined in these models. Differences in transferase activity levels were found between tissues and cell types and during mouse development. No specific patterns of activities were associated with the lack of CFTR or with DeltaF508CFTR expression. This suggests that it is not the presence or absence of normal CFTR, or the presence of m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001243"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001243"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001243; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001243]").text(description); $(".js-view-count[data-work-id=114001243]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001243; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001243']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114001243]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001243,"title":"Biosynthesis of mucin type O-glycans: lack of correlation between glycosyltransferase and sulfotransferase activities and CFTR expression","internal_url":"https://www.academia.edu/114001243/Biosynthesis_of_mucin_type_O_glycans_lack_of_correlation_between_glycosyltransferase_and_sulfotransferase_activities_and_CFTR_expression","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001242"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001242/Early_age_feed_restriction_affects_viability_and_gene_expression_of_satellite_cells_isolated_from_the_gastrocnemius_muscle_of_broiler_chicks"><img alt="Research paper thumbnail of Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks" class="work-thumbnail" src="https://attachments.academia-assets.com/110815087/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001242/Early_age_feed_restriction_affects_viability_and_gene_expression_of_satellite_cells_isolated_from_the_gastrocnemius_muscle_of_broiler_chicks">Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks</a></div><div class="wp-workCard_item"><span>Journal of animal science and biotechnology</span><span>, Jan 6, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We repo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We reported previously that 0-14 day intermittent feeding led to persistent retardation in myofiber hypertrophy. However, how satellite cells respond to such nutritional insult has not been adequately elucidated. One-day-old broiler chicks were allocated to control (Con, ad libitum feeding), intermittent feeding (IF, feed provided on alternate days) and re-feeding (RF, 2 days ad libitum feeding after 12 days of intermittent feeding) groups. Chickens were killed on Day 15 and satellite cells were isolated. When cultured, satellite cells from the IF group demonstrated significant retardation in proliferation and differentiation potential, while RF partly restored the proliferation rate and differentiation potential of the satellite cells. Significant up-regulation of insulin like growth factor I receptor (IGF-IR) (P&lt;0.05) and thyroid hormone receptor α (TRα) (P&lt;0.05), and down-regulation of...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c84d495d9273e196cb945851390b07c9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815087,"asset_id":114001242,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815087/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001242"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001242"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001242; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001242]").text(description); $(".js-view-count[data-work-id=114001242]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001242; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001242']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c84d495d9273e196cb945851390b07c9" } } $('.js-work-strip[data-work-id=114001242]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001242,"title":"Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks","internal_url":"https://www.academia.edu/114001242/Early_age_feed_restriction_affects_viability_and_gene_expression_of_satellite_cells_isolated_from_the_gastrocnemius_muscle_of_broiler_chicks","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815087,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815087/thumbnails/1.jpg","file_name":"2049-1891-3-33.pdf","download_url":"https://www.academia.edu/attachments/110815087/download_file","bulk_download_file_name":"Early_age_feed_restriction_affects_viabi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815087/2049-1891-3-33-libre.pdf?1706152086=\u0026response-content-disposition=attachment%3B+filename%3DEarly_age_feed_restriction_affects_viabi.pdf\u0026Expires=1741342416\u0026Signature=PtMy~qCa94Ad~UjfBIAuTEARd5aztFzt8CEvW8wDGhTY6m7l84DQVpTKDAuGr0Ic956btEmQ-5r5-qLHR3Zpqt7eI-MZwgQ1eXyuK3RNNvgLiyAHWYcQXLclr0ws1CH1CZu7TWxIRkiEYazjY25s6frciK-W8wWL7fdprNOX5SdfYhpHV444o2QU5RYD3Hx2hNpCK8Ah~qQtP9ku5k7QHcqXTO0EKEdPKykaRlhn9SMSvMtoLntJk1MvBrtIc1LT2c~yTqFk1ItNAp3CN-eAcm594CophxQzZFXZrRQFmULgxAIOkNYoE9Lp9OviiNyTkP3RevD7eL3KbcS49gUVow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001241"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001241/CD133_CD44_Cells_Mediate_in_the_Lung_Metastasis_of_Osteosarcoma"><img alt="Research paper thumbnail of CD133+CD44+Cells Mediate in the Lung Metastasis of Osteosarcoma" class="work-thumbnail" src="https://attachments.academia-assets.com/110815091/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001241/CD133_CD44_Cells_Mediate_in_the_Lung_Metastasis_of_Osteosarcoma">CD133+CD44+Cells Mediate in the Lung Metastasis of Osteosarcoma</a></div><div class="wp-workCard_item"><span>Journal of Cellular Biochemistry</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This article has been accepted for publication and undergone full peer review but has not been th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="329c8d843be047defa81ac0905b2823d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815091,"asset_id":114001241,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815091/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001241"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001241"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001241; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001241]").text(description); $(".js-view-count[data-work-id=114001241]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001241; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001241']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "329c8d843be047defa81ac0905b2823d" } } $('.js-work-strip[data-work-id=114001241]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001241,"title":"CD133+CD44+Cells Mediate in the Lung Metastasis of Osteosarcoma","internal_url":"https://www.academia.edu/114001241/CD133_CD44_Cells_Mediate_in_the_Lung_Metastasis_of_Osteosarcoma","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815091,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815091/thumbnails/1.jpg","file_name":"jcb.2513120240125-1-twfo6t.pdf","download_url":"https://www.academia.edu/attachments/110815091/download_file","bulk_download_file_name":"CD133_CD44_Cells_Mediate_in_the_Lung_Met.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815091/jcb.2513120240125-1-twfo6t-libre.pdf?1706152079=\u0026response-content-disposition=attachment%3B+filename%3DCD133_CD44_Cells_Mediate_in_the_Lung_Met.pdf\u0026Expires=1741342416\u0026Signature=Kg2yniCL8Hq~kv4BNOMqI3ntTDPiveigtjly-EVovZl7vO3TzJtkeznhxgwUcTDpbNXfh~t9zImfsQe18iSzeerFTvnkd3i-iCCTLePEu7HOHLiAqqNJxnZeAUkWgp-BJDdgeB9TXSmL~E1rIkEUcQSBdxmceIVrtuFoqpLcDLPLSHfZUVhBK4-0sYsPoZYcokTKpHo8ayMn4MzEzsNMArm19KoSDXPe880ls2GjTmFuRmLtd3Ed5Eh3rMe3vkLWaCyFRisz4OwXUt8wYO83pqa4VFn4Ct7mOuroblwOGrElNKCZX7kfdPSPlY66zl8ueOSwZpjVEunT-JvasZ~mHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001240"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001240/Reliable_cell_cycle_commitment_in_budding_yeast_is_ensured_by_signal_integration"><img alt="Research paper thumbnail of Reliable cell cycle commitment in budding yeast is ensured by signal integration" class="work-thumbnail" src="https://attachments.academia-assets.com/110815093/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001240/Reliable_cell_cycle_commitment_in_budding_yeast_is_ensured_by_signal_integration">Reliable cell cycle commitment in budding yeast is ensured by signal integration</a></div><div class="wp-workCard_item"><span>eLife</span><span>, Jan 15, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cell fate decisions are critical for life, yet little is known about how their reliability is ach...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We further identify the Start repressor, Whi5, as the integrator. The instantaneous kinase activity of Cln3-Cdk1 is recorded over time on the phosphorylated Whi5, and the decision is made only when phosphorylated Whi5 reaches a threshold. Cells adjust the threshold by modulating Whi5 concentration in different nutrient conditions to coordinate growth and division. Our work shows that the strategy of signal integration, which was previously found in decision-making behaviors of animals, is adopted at the cellular level to reduce noise and minimize uncertainty.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea52aaf831a6d9b518dd4e065aa74cd6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815093,"asset_id":114001240,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815093/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001240"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001240"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001240; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001240]").text(description); $(".js-view-count[data-work-id=114001240]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001240; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001240']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ea52aaf831a6d9b518dd4e065aa74cd6" } } $('.js-work-strip[data-work-id=114001240]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001240,"title":"Reliable cell cycle commitment in budding yeast is ensured by signal integration","internal_url":"https://www.academia.edu/114001240/Reliable_cell_cycle_commitment_in_budding_yeast_is_ensured_by_signal_integration","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815093,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815093/thumbnails/1.jpg","file_name":"elife-03977-v3.pdf","download_url":"https://www.academia.edu/attachments/110815093/download_file","bulk_download_file_name":"Reliable_cell_cycle_commitment_in_buddin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815093/elife-03977-v3-libre.pdf?1706152085=\u0026response-content-disposition=attachment%3B+filename%3DReliable_cell_cycle_commitment_in_buddin.pdf\u0026Expires=1741342416\u0026Signature=RmquG6jD6JyWxV-uSfuZDiEDUsmCCV8uB2t6gMSmTUi2MISkymbe1TrdIv3N0iwjKnjE3PgsvB9eh-jgZTkEpVbz8Pjeu9r~iXU~JddK3NtEFZXKgrzrg-de83tF1-9KsGlcROkV-bdtS~Iak29bdaGnfpIWVkAK2bd9WYcMpInTr73H-loZ4dzhezPjiaxFoY50zLvPaBIu6JfwXepF40oslW31O03-pQi3Tsm0vOY-2mo7OsQV1CkTbZ~sipSBjexUTRKvrk7MuZzvHpRrxINzuwAEhetKPnq6kwbB5Jq0N0~8kq5iQPTqekHG9GsJOIEH6Etxobxy6Od6RY-tOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001239"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001239/Integrative_epigenome_analysis_identifies_a_Polycomb_targeted_differentiation_program_as_a_tumor_suppressor_event_epigenetically_inactivated_in_colorectal_cancer"><img alt="Research paper thumbnail of Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/110815089/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001239/Integrative_epigenome_analysis_identifies_a_Polycomb_targeted_differentiation_program_as_a_tumor_suppressor_event_epigenetically_inactivated_in_colorectal_cancer">Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer</a></div><div class="wp-workCard_item"><span>Cell Death & Disease</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aberrant DNA hypermethylation in human cancer has been associated with Polycomb target genes in e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aberrant DNA hypermethylation in human cancer has been associated with Polycomb target genes in embryonic stem (ES) cells, but a functional link of the Polycomb-targeted differentiation program to tumorigenesis remains to be established. Here, through epigenome analysis correlating DNA hypermethylation in colon cancer with ES cell pluripotency and differentiation, we identified a set of DNA hypermethylated genes in cancer cells that are Polycomb targets strongly associated with ES cell differentiation, including HAND1, a developmental regulator. Intriguingly, HAND1 is silenced in over 90% of human primary colorectal tumors, and re-expression of HAND1 in colon cancer cells induces terminal differentiation, inhibits proliferation and prevents xenograft tumor formation. Moreover, hypermethylated HAND1 has a minimum enrichment of EZH2-H3K27me3 in cancer cells, but becomes EZH2 bound and bivalent upon the loss of DNA methylation, suggesting a sequential gene silencing event during oncogenesis. These findings established a functional role of Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in human cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efb0f8ab52b261e81e3e33c13eb2917f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815089,"asset_id":114001239,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815089/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001239"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001239"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001239; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001239]").text(description); $(".js-view-count[data-work-id=114001239]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001239; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001239']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001238"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001238/Role_of_EHD2_in_migration_and_invasion_of_human_breast_cancer_cells"><img alt="Research paper thumbnail of Role of EHD2 in migration and invasion of human breast cancer cells" class="work-thumbnail" src="https://attachments.academia-assets.com/110815092/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001238/Role_of_EHD2_in_migration_and_invasion_of_human_breast_cancer_cells">Role of EHD2 in migration and invasion of human breast cancer cells</a></div><div class="wp-workCard_item"><span>Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</span><span>, Jan 5, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Eps15 homology domain-containing 2 (EHD2) is a tumor suppressor gene, overexpressed in several so...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Eps15 homology domain-containing 2 (EHD2) is a tumor suppressor gene, overexpressed in several solid tumors, including ovarian cancer and esophageal squamous cell carcinoma. The current study examined the expression and the role of EHD2 in human breast cancer. EHD2 expression was determined by Western blot and immunohistochemistry (IHC) in 80 breast cancer and paired noncancerous breast tissues. Correlations between clinicopathologic variables, overall survival, and EHD2 expression were analyzed. We investigated the role of EHD2 in breast cancer migration and invasion by wound healing assay and trans-well invasion assays. A notably lower level of EHD2 expression was found in breast cancer tissues. EHD2 expression was associated with histological grade, lymph node metastasis, and tumor size. Expression of EHD2 was found to be an independent prognostic factor in breast cancer patients. Furthermore, overexpression of EHD2 suppressed, while elimination of EHD2 promoted, the migration an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="72f59a3cfb3ecd99fef314b665d1c0b3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815092,"asset_id":114001238,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815092/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001238"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001238"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001238; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001238]").text(description); $(".js-view-count[data-work-id=114001238]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001238; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001238']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "72f59a3cfb3ecd99fef314b665d1c0b3" } } $('.js-work-strip[data-work-id=114001238]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001238,"title":"Role of EHD2 in migration and invasion of human breast cancer cells","internal_url":"https://www.academia.edu/114001238/Role_of_EHD2_in_migration_and_invasion_of_human_breast_cancer_cells","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815092,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815092/thumbnails/1.jpg","file_name":"s13277-014-3011-920240125-1-ztfvy2.pdf","download_url":"https://www.academia.edu/attachments/110815092/download_file","bulk_download_file_name":"Role_of_EHD2_in_migration_and_invasion_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815092/s13277-014-3011-920240125-1-ztfvy2-libre.pdf?1706152077=\u0026response-content-disposition=attachment%3B+filename%3DRole_of_EHD2_in_migration_and_invasion_o.pdf\u0026Expires=1741342416\u0026Signature=PToA0aC2WqgOQWdR5tBVxuTe~rFd2mziHs6s9wjwPkJwtmCWF526HVPYvsIvxupIGV-x3qPPUyj~czTlcoURsQfxaVBELnEOeFzpUNDN3V2TSxHILrDLJl3Iyci5seI~DMxQDnp6QF2KiFg9uoJTRFGfZqfMkZej-h4fEPucqwiyzBJsU9cZg~4M1lvLy6QTBxW5ksTwEpug2rCDmuj5eeogjIn7Bd~Kx-iphIhh38glJl0UokvkPg1-~m9ogdniRlfYQkpBlufg7DL0PyPZ9pcmNJ5KktuQRjmtcHVna7fll45RZyB8k959oKccQmvgjXBq29Webqj3I8-pmat2Dg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001237"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001237/Low_expression_of_cyclic_AMP_response_element_modulator_1_can_increase_the_migration_and_invasion_of_esophageal_squamous_cell_carcinoma"><img alt="Research paper thumbnail of Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/110815107/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001237/Low_expression_of_cyclic_AMP_response_element_modulator_1_can_increase_the_migration_and_invasion_of_esophageal_squamous_cell_carcinoma">Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma</a></div><div class="wp-workCard_item"><span>Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cyclic AMP response element-binding protein (CREB) family can regulate biological functions of va...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cyclic AMP response element-binding protein (CREB) family can regulate biological functions of various types of cells and has relation with esophageal cancer cell migration and invasion. Cyclic AMP response element modulator-1 (CREM-1) is one member of the family with limited acquaintance. This study was conducted to investigate the effect of CREM-1 on migration and invasion in human esophageal squamous cell carcinoma (ESCC). The expression of CREM-1 protein in ESCC tissues with or without lymph nodes metastasis was determined by western blot. Immunohistochemical analysis of CREM-1 expression were carried out in paraffin-embedded sections of ESCC and correlated with clinical features. The roles of CREM-1 in migration and invasion were studied in TE1 cells through knocking CREM-1 down with siRNA or overexpression of CREM-1 in ECA109 cells. The regulations of CREM-1 on invasion and migration were determined by transwell and wounding healing assay. The effect of CREM-1 on chemotherapy ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9fbd0c2fbed6ef8b2d3305827be4b6ac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815107,"asset_id":114001237,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815107/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001237"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001237"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001237; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001237]").text(description); $(".js-view-count[data-work-id=114001237]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001237; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001237']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9fbd0c2fbed6ef8b2d3305827be4b6ac" } } $('.js-work-strip[data-work-id=114001237]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001237,"title":"Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma","internal_url":"https://www.academia.edu/114001237/Low_expression_of_cyclic_AMP_response_element_modulator_1_can_increase_the_migration_and_invasion_of_esophageal_squamous_cell_carcinoma","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815107,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815107/thumbnails/1.jpg","file_name":"s13277-013-0946-120240125-1-r3vs5a.pdf","download_url":"https://www.academia.edu/attachments/110815107/download_file","bulk_download_file_name":"Low_expression_of_cyclic_AMP_response_el.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815107/s13277-013-0946-120240125-1-r3vs5a-libre.pdf?1706152074=\u0026response-content-disposition=attachment%3B+filename%3DLow_expression_of_cyclic_AMP_response_el.pdf\u0026Expires=1741342416\u0026Signature=eKN7laKie3YCnBuz1oBRiH7FcV-noTgpXy639QMB8DRcm6ghwXd2aDGcPjZalO8nnHi2FWmpV9uMa~L5yVtEZL0MOOouS0CzJh4MjreQwtSjPSsSpfrhyuzz42xuk1tjvQIHZgT97gbSibNeaiAdkJzFZzrL5xsiAqOg1F5edYStR32NrRLeFytSqQ2pJFL4kS7PCmKmBqto87enccJh3cpvc04Dncbqp5rzN5~Grf0D1YUi45SjFZN8n0ctRD5pUPf-LGF2B-mpmXznfPx-3AGsDTOZ2WuRsz55YIWgXqHd4U9y5aDn1J7hBpvZ2l25ocCpEXOAMR-qwTDw1fsOmA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001236"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001236/Gene_body_methylation_can_alter_gene_expression_and_is_a_therapeutic_target_in_cancer"><img alt="Research paper thumbnail of Gene body methylation can alter gene expression and is a therapeutic target in cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/110815099/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001236/Gene_body_methylation_can_alter_gene_expression_and_is_a_therapeutic_target_in_cancer">Gene body methylation can alter gene expression and is a therapeutic target in cancer</a></div><div class="wp-workCard_item"><span>Cancer cell</span><span>, Jan 13, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">DNA methylation in promoters is well known to silence genes and is the presumed therapeutic targe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">DNA methylation in promoters is well known to silence genes and is the presumed therapeutic target of methylation inhibitors. Gene body methylation is positively correlated with expression, yet its function is unknown. We show that 5-aza-2&#39;-deoxycytidine treatment not only reactivates genes but decreases the overexpression of genes, many of which are involved in metabolic processes regulated by c-MYC. Downregulation is caused by DNA demethylation of the gene bodies and restoration of high levels of expression requires remethylation by DNMT3B. Gene body methylation may, therefore, be an unexpected therapeutic target for DNA methylation inhibitors, resulting in the normalization of gene overexpression induced during carcinogenesis. Our results provide direct evidence for a causal relationship between gene body methylation and transcription.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cdd18d4b693c72789b3a5c5ce9a5d528" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815099,"asset_id":114001236,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815099/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001236"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001236"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001236; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001236]").text(description); $(".js-view-count[data-work-id=114001236]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001236; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001236']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001235"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001235/A_low_level_of_GPR37_is_associated_with_human_hepatocellular_carcinoma_progression_and_poor_patient_survival"><img alt="Research paper thumbnail of A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001235/A_low_level_of_GPR37_is_associated_with_human_hepatocellular_carcinoma_progression_and_poor_patient_survival">A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival</a></div><div class="wp-workCard_item"><span>Pathology, research and practice</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR). It has been reported that GPCRs play vital roles in the development and progression of cancer. To investigate the potential roles of GPR37 in hepatocellular carcinoma (HCC), expression of GPR37 was examined in human HCC samples. Immunohistochemistry and Western blot analyses were performed for GPR37 in 57 hepatocellular carcinoma samples. GPR37 expression was low in hepatocellular carcinoma as compared with the adjacent non-tumorous tissues. Clinicopathological analysis showed that GPR37 expression was significantly correlated with histological grade and the level of alpha fetal protein (AFP) (P = 0.000 and 0.002, respectively). The Kaplan-Meier survival curves revealed that decreasing GPR37 expression was associated with poor prognosis in HCC patients, while in vitro, following the release from serum starvation of HuH7 HCC cell, the expression of GPR37 was downr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001235"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001235"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001235; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001235]").text(description); $(".js-view-count[data-work-id=114001235]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001235; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001235']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="19154886" id="papers"><div class="js-work-strip profile--work_container" data-work-id="114001254"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001254/Robust_switch_like_destruction_of_the_CDK_inhibitor_Sic1_is_ensured_by_a_double_negative_feedback_loop"><img alt="Research paper thumbnail of Robust switch-like destruction of the CDK inhibitor Sic1 is ensured by a double negative feedback loop" class="work-thumbnail" src="https://attachments.academia-assets.com/110815094/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001254/Robust_switch_like_destruction_of_the_CDK_inhibitor_Sic1_is_ensured_by_a_double_negative_feedback_loop">Robust switch-like destruction of the CDK inhibitor Sic1 is ensured by a double negative feedback loop</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In eukaryotic cell division cycles, the initiation of DNA replication (S-phase entry) is driven b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In eukaryotic cell division cycles, the initiation of DNA replication (S-phase entry) is driven by a sharp rise in the activity of the S-phase cyclin-Cdk. A critical step leading to this G1/S transition in yeast is the rapid proteolytic degradation of the S-phase cyclin (Clb5/6)-Cdk stoichiometric inhibitor Sic1. Multisite phosphorylation by G1 cyclin (Cln)-Cdk is thought to be responsible for Sic1's switchlike destruction. Here, by monitoring Sic1 degradation in real time in individual cells, we show that it is the double-negative feedback loop between Clb5/6-Cdk and Sic1, not Cln-Cdk, that ensures a robust rapid destruction of Sic1 against genetic and environmental perturbations. Our study establishes a new understanding on the control mechanism of G1/S progression and provides insights in the coordination of cell cycle transitions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="82a3a7cc574639df2dcae265a15e4a64" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815094,"asset_id":114001254,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815094/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001254"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001254"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001254; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001254]").text(description); $(".js-view-count[data-work-id=114001254]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001254; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001254']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "82a3a7cc574639df2dcae265a15e4a64" } } $('.js-work-strip[data-work-id=114001254]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001254,"title":"Robust switch-like destruction of the CDK inhibitor Sic1 is ensured by a double negative feedback loop","internal_url":"https://www.academia.edu/114001254/Robust_switch_like_destruction_of_the_CDK_inhibitor_Sic1_is_ensured_by_a_double_negative_feedback_loop","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815094,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815094/thumbnails/1.jpg","file_name":"10_038_absract.pdf","download_url":"https://www.academia.edu/attachments/110815094/download_file","bulk_download_file_name":"Robust_switch_like_destruction_of_the_CD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815094/10_038_absract-libre.pdf?1706152072=\u0026response-content-disposition=attachment%3B+filename%3DRobust_switch_like_destruction_of_the_CD.pdf\u0026Expires=1741342416\u0026Signature=T~4T8e4auszq3PbScU17wXBJ8H3A3GHLAOIwbtTVaf3s9tsTisNKpphW0hoSGdhZCpVGUSIoImnpTPc55kxqQj4AM2vmglk2lHGt1sdvbCqNyH~HR24YpH8WvMta0ImmYVq4hadboua1S3cvRLsWt5hky2GK5ssTXrC3NAod4Z0~yMhMj1Hp2PEnQsBwETsML-vn9tcHaO4PH91VqNIdac0BLqJBHow0qIs~RH9rjd0OeklZQQp6RfOei0riyO3~OnbJ-SJfDtnul~k4B6HFrXBZn8sBYGhjvao8B5XzBNKOWO70UVdfv-oldzSyWzwKRmDesGnf-XzxrAJsiaPlxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001253"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001253/Structure_of_the_response_regulator_RPA3017_involved_in_red_light_signaling_in_Rhodopseudomonas_palustris"><img alt="Research paper thumbnail of Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris" class="work-thumbnail" src="https://attachments.academia-assets.com/110815103/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001253/Structure_of_the_response_regulator_RPA3017_involved_in_red_light_signaling_in_Rhodopseudomonas_palustris">Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris</a></div><div class="wp-workCard_item"><span>Acta crystallographica. Section F, Structural biology communications</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Two-component signal transduction is the major signaling mechanism that enables bacteria to survi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Two-component signal transduction is the major signaling mechanism that enables bacteria to survive and thrive in complex environmental conditions. The photosynthetic bacterium R. palustris employs two tandem bacteriophytochromes, RpBphP2 and RpBphP3, to perceive red-light signals that regulate the synthesis of light-harvesting complexes under low-light conditions. Both RpBphP2 and RpBphP3 are photosensory histidine kinases coupled to the same response regulator RPA3017. Together, they constitute a two-component system that converts a red-light signal into a biological signal. In this work, the crystal structure of RPA3017 in the unphosphorylated form at 1.9 Å resolution is presented. This structure reveals a tightly associated dimer arrangement that is conserved among phytochrome-related response regulators. The conserved active-site architecture provides structural insight into the phosphotransfer reaction between RpBphP2/RpBphP3 and RPA3017. Based on structural comparisons and ho...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="68f58f64c4d0fefb86c007e53b3abd85" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815103,"asset_id":114001253,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815103/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001253"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001253"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001253; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001252"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001252/Intravenous_injection_of_microvesicle_delivery_miR_130b_alleviates_high_fat_diet_induced_obesity_in_C57BL_6_mice_through_translational_repression_of_PPAR_%CE%B3"><img alt="Research paper thumbnail of Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ" class="work-thumbnail" src="https://attachments.academia-assets.com/110815095/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001252/Intravenous_injection_of_microvesicle_delivery_miR_130b_alleviates_high_fat_diet_induced_obesity_in_C57BL_6_mice_through_translational_repression_of_PPAR_%CE%B3">Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ</a></div><div class="wp-workCard_item"><span>Journal of biomedical science</span><span>, Jan 16, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to targe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat deposition and glucose homeostasis remains unknown. Three-week-old C57BL/6 mice were fed a high-fat diet for 8 weeks and then intravenously injected with MV-packaged scrambled control microRNA (miRNA) or miR-130b every other day for 10 days. Glucose tolerance test was performed and body weight, epididymal fat weight, as well as the expression of lipid metabolic genes were determined. We showed that mice fed on high-fat diet for 8 weeks demonstrated significantly higher body weight, elevated blood glucose and impaired glucose tolerance. miR-130b-MV injection significantly reduced body weight and epididymal fat weight and partly restored glucose tolerance. miR-130b expression was significantly increased in the epididymal fat after miR-130b-MV injection while the protein content ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a5c264410a6f06c09239a9724576721" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815095,"asset_id":114001252,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815095/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001252"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001252"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001252; 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</script> <div class="js-work-strip profile--work_container" data-work-id="114001249"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001249/Controllable_synthesis_and_characterization_of_porous_FeVO4_nanorods_and_nanoparticles"><img alt="Research paper thumbnail of Controllable synthesis and characterization of porous FeVO4 nanorods and nanoparticles" class="work-thumbnail" src="https://attachments.academia-assets.com/110815088/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001249/Controllable_synthesis_and_characterization_of_porous_FeVO4_nanorods_and_nanoparticles">Controllable synthesis and characterization of porous FeVO4 nanorods and nanoparticles</a></div><div class="wp-workCard_item"><span>CrystEngComm</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fe 3 O 4 /Au composite nanoparticles (GoldMag NPs) have received considerable attention because o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fe 3 O 4 /Au composite nanoparticles (GoldMag NPs) have received considerable attention because of their advantageous properties arisen from both individual Au and Fe 3 O 4 nanoparticles. Many efforts have been devoted to the synthesis of these composite nanoparticles. Herein, GoldMag NPs were reported to be synthesized by two-step method. Fe 3 O 4 nanoparticles were prepared by co-precipitation and modified by the citric acid, and then citric acid-coated Fe 3 O 4 nanoparticles were used as seeds in sodium citrate solution to reduce the HAuCl 4. The size of obtained nanoparticles was geared from 25 to 300 nm by controlling the concentration of reactants. The GoldMag NPs were characterized by UV-vis spectrometer, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). The GoldMag NPs showed good superparamagnetism at room temperature and were well dispersed in water with surface plasmon resonance absorption peak varied from 538 nm to 570 nm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b0836ad11bed0819d3b6244eddeaa8c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815088,"asset_id":114001249,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815088/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001249"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001249"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001249; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001248"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001248/Light_signaling_mechanism_of_two_tandem_bacteriophytochromes"><img alt="Research paper thumbnail of Light signaling mechanism of two tandem bacteriophytochromes" class="work-thumbnail" src="https://attachments.academia-assets.com/110815090/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001248/Light_signaling_mechanism_of_two_tandem_bacteriophytochromes">Light signaling mechanism of two tandem bacteriophytochromes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highlights d RpBphP2 and RpBphP3 adopt similar tertiary structures but different dimer scaffolds ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highlights d RpBphP2 and RpBphP3 adopt similar tertiary structures but different dimer scaffolds d Residues at the GAF-PHY interface modulate photoconversion properties d A single mutation (T480P) in RpBphP3 enables canonical photoconversion d Angular orientation between PHY and HK domains is crucial for long-range signaling</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="56a107d975b73a5f8d206e32bcfe3ebc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815090,"asset_id":114001248,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815090/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001248"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001248"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001248; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001247"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001247/Direct_electrochemistry_and_electrocatalysis_of_hemoglobin_at_three_dimensional_gold_film_electrode_modified_with_self_assembled_monolayers_of_3_mercaptopropylphosphonic_acid"><img alt="Research paper thumbnail of Direct electrochemistry and electrocatalysis of hemoglobin at three-dimensional gold film electrode modified with self-assembled monolayers of 3-mercaptopropylphosphonic acid" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001247/Direct_electrochemistry_and_electrocatalysis_of_hemoglobin_at_three_dimensional_gold_film_electrode_modified_with_self_assembled_monolayers_of_3_mercaptopropylphosphonic_acid">Direct electrochemistry and electrocatalysis of hemoglobin at three-dimensional gold film electrode modified with self-assembled monolayers of 3-mercaptopropylphosphonic acid</a></div><div class="wp-workCard_item"><span>Analytica Chimica Acta</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Multilayered hemoglobin (Hb) molecules were successfully immobilized on three-dimensional gold fi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Multilayered hemoglobin (Hb) molecules were successfully immobilized on three-dimensional gold film electrode modified with self-assembled monolayers (SAMs) of 3-mercaptopropylphosphonic acid. Direct electrochemistry of the immobilized multilayered Hb occurs with high thermal stability and electrochemical stability. In the multilayered Hb film, the most inner Hb molecules can directly transfer electron with the electrode, while the Hb protein beyond this layer communicates</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001247"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001247"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001247; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001246"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001246/YfiT_from_Bacillus_subtilis_is_a_probable_metal_dependent_hydrolase_with_an_unusual_four_helix_bundle_topology"><img alt="Research paper thumbnail of YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001246/YfiT_from_Bacillus_subtilis_is_a_probable_metal_dependent_hydrolase_with_an_unusual_four_helix_bundle_topology">YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology</a></div><div class="wp-workCard_item"><span>Biochemistry</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">YfiT, a 19-kDa polypeptide from Bacillus subtilis, belongs to a small sequence family with member...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">YfiT, a 19-kDa polypeptide from Bacillus subtilis, belongs to a small sequence family with members predominantly from Gram positive bacteria. We have determined the crystal structure of YfiT in complex with Ni(2+) to a resolution of 1.7 A. YfiT exists as a dimer and binds Ni(2+) in a 1:1 stoichiometry. The protein has an unusual four-helix bundle topology and coordinates Ni(2+) in an octahedral geometry with three conserved histidines and three waters. Although there is no similarity in their overall structures, the coordination geometry of the metal and the residues that constitute the putative active site in YfiT are similar to those of metalloproteases such as thermolysin. Our structural analyses suggest that YfiT might function as a metal-dependent hydrolase.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001246"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001246"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001246; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001246]").text(description); 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</script> <div class="js-work-strip profile--work_container" data-work-id="114001245"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001245/Recombinant_Hamster_Oviductin_Is_Biologically_Active_and_Exerts_Positive_Effects_on_Sperm_Functions_and_Sperm_Oocyte_Binding"><img alt="Research paper thumbnail of Recombinant Hamster Oviductin Is Biologically Active and Exerts Positive Effects on Sperm Functions and Sperm-Oocyte Binding" class="work-thumbnail" src="https://attachments.academia-assets.com/110815113/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001245/Recombinant_Hamster_Oviductin_Is_Biologically_Active_and_Exerts_Positive_Effects_on_Sperm_Functions_and_Sperm_Oocyte_Binding">Recombinant Hamster Oviductin Is Biologically Active and Exerts Positive Effects on Sperm Functions and Sperm-Oocyte Binding</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Studies carried out in several mammalian species suggest that oviductin, also known as oviduct-sp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Studies carried out in several mammalian species suggest that oviductin, also known as oviduct-specific glycoprotein or OVGP1, plays a key role in sperm capacitation, fertilization, and development of early embryos. In the present study, we used recombinant DNA technology to produce, for the first time, recombinant hamster OVGP1 (rHamOVGP1) in human embryonic kidney 293 (HEK293) cells. rHamOVGP1 secreted in the culture medium was purified by affinity chromatography. The resulting protein migrated as a poly-dispersed band of 160-350 kDa on SDS-PAGE corresponding to the molecular mass of the native HamOVGP1. Subsequent mass spectrometric analysis of the purified rHamOVGP1 confirmed its identity as HamOVGP1. Immunocytochemistry demonstrated binding of rHamOVGP1 to the mid-piece and head of hamster sperm and to the zona pellucida (ZP) of ovarian oocytes. In vitro functional experiments showed that addition of rHamOVGP1 in the capacitation medium further enhanced tyrosine phosphorylation...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="20945ac7e7b291e69a74459d6b1d0c95" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815113,"asset_id":114001245,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815113/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001245"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001245"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001245; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "20945ac7e7b291e69a74459d6b1d0c95" } } $('.js-work-strip[data-work-id=114001245]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001245,"title":"Recombinant Hamster Oviductin Is Biologically Active and Exerts Positive Effects on Sperm Functions and Sperm-Oocyte Binding","internal_url":"https://www.academia.edu/114001245/Recombinant_Hamster_Oviductin_Is_Biologically_Active_and_Exerts_Positive_Effects_on_Sperm_Functions_and_Sperm_Oocyte_Binding","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815113,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815113/thumbnails/1.jpg","file_name":"c85a4bbf80dd852cee12b3eb62ac1f72eff2.pdf","download_url":"https://www.academia.edu/attachments/110815113/download_file","bulk_download_file_name":"Recombinant_Hamster_Oviductin_Is_Biologi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815113/c85a4bbf80dd852cee12b3eb62ac1f72eff2-libre.pdf?1706152080=\u0026response-content-disposition=attachment%3B+filename%3DRecombinant_Hamster_Oviductin_Is_Biologi.pdf\u0026Expires=1741342416\u0026Signature=Q9CsLrQZjPeRxr6EgyMVqMh7f9b~8so3-Rl2t57U67Xn6n1QGXI1kFP8IJbK7fWJDVE--Dkz-otACqhRo5x3HbfiJBYiajiFG1bXHRtVjFtaHyJl4QQXm7vdwX8m7u3xr8R46XcJ4eSgmPK04IPbntUxlgWDE5tv8KI~gVeHMyh8mhdH-nWToetS2VdkYz3fdRViKiZHdc1BQ1LReMb2QWDMf9JJhUvNaeh8yXFSqPdVYiyAWr2HWMgxxEuO4BKDLyMZ0i4h3aZyPCpjvtfUHRT-FY8E9ARw4dtb2r1c1O-XwgqzWBj3bAOr2g13uGKKTNObQh20rpcIBfrPXuDt7A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001244"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001244/Biliproteins_and_their_Applications_in_Bioimaging"><img alt="Research paper thumbnail of Biliproteins and their Applications in Bioimaging" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001244/Biliproteins_and_their_Applications_in_Bioimaging">Biliproteins and their Applications in Bioimaging</a></div><div class="wp-workCard_item"><span>Procedia Chemistry</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001244"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001244"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001244; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001244]").text(description); $(".js-view-count[data-work-id=114001244]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001244; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001244']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114001244]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001244,"title":"Biliproteins and their Applications in Bioimaging","internal_url":"https://www.academia.edu/114001244/Biliproteins_and_their_Applications_in_Bioimaging","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001243"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001243/Biosynthesis_of_mucin_type_O_glycans_lack_of_correlation_between_glycosyltransferase_and_sulfotransferase_activities_and_CFTR_expression"><img alt="Research paper thumbnail of Biosynthesis of mucin type O-glycans: lack of correlation between glycosyltransferase and sulfotransferase activities and CFTR expression" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001243/Biosynthesis_of_mucin_type_O_glycans_lack_of_correlation_between_glycosyltransferase_and_sulfotransferase_activities_and_CFTR_expression">Biosynthesis of mucin type O-glycans: lack of correlation between glycosyltransferase and sulfotransferase activities and CFTR expression</a></div><div class="wp-workCard_item"><span>Glycoconjugate journal</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Structural differences have been reported in the glycosylation patterns of cystic fibrosis glycop...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Structural differences have been reported in the glycosylation patterns of cystic fibrosis glycoproteins. Although the gene mutated in cystic fibrosis (CFTR) has been cloned and characterized as a chloride channel, its relationship to the highly viscous mucus and structural glycoprotein and mucin abnormalities in cystic fibrosis still remains to be defined. We have evaluated O-glycan biosynthesis in CHO and BHK cells that express CFTR and DeltaF508 CFTR as in vitro models, and utilized the cftr knockout mouse as an in vivo model of CFTR dysfunction. Activities of glycosyltransferases and sulfotransferases synthesizing mucin type O-glycan chains were determined in these models. Differences in transferase activity levels were found between tissues and cell types and during mouse development. No specific patterns of activities were associated with the lack of CFTR or with DeltaF508CFTR expression. This suggests that it is not the presence or absence of normal CFTR, or the presence of m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001243"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001243"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001243; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001243]").text(description); $(".js-view-count[data-work-id=114001243]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001243; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001243']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114001243]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001243,"title":"Biosynthesis of mucin type O-glycans: lack of correlation between glycosyltransferase and sulfotransferase activities and CFTR expression","internal_url":"https://www.academia.edu/114001243/Biosynthesis_of_mucin_type_O_glycans_lack_of_correlation_between_glycosyltransferase_and_sulfotransferase_activities_and_CFTR_expression","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001242"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001242/Early_age_feed_restriction_affects_viability_and_gene_expression_of_satellite_cells_isolated_from_the_gastrocnemius_muscle_of_broiler_chicks"><img alt="Research paper thumbnail of Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks" class="work-thumbnail" src="https://attachments.academia-assets.com/110815087/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001242/Early_age_feed_restriction_affects_viability_and_gene_expression_of_satellite_cells_isolated_from_the_gastrocnemius_muscle_of_broiler_chicks">Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks</a></div><div class="wp-workCard_item"><span>Journal of animal science and biotechnology</span><span>, Jan 6, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We repo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We reported previously that 0-14 day intermittent feeding led to persistent retardation in myofiber hypertrophy. However, how satellite cells respond to such nutritional insult has not been adequately elucidated. One-day-old broiler chicks were allocated to control (Con, ad libitum feeding), intermittent feeding (IF, feed provided on alternate days) and re-feeding (RF, 2 days ad libitum feeding after 12 days of intermittent feeding) groups. Chickens were killed on Day 15 and satellite cells were isolated. When cultured, satellite cells from the IF group demonstrated significant retardation in proliferation and differentiation potential, while RF partly restored the proliferation rate and differentiation potential of the satellite cells. Significant up-regulation of insulin like growth factor I receptor (IGF-IR) (P&lt;0.05) and thyroid hormone receptor α (TRα) (P&lt;0.05), and down-regulation of...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c84d495d9273e196cb945851390b07c9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815087,"asset_id":114001242,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815087/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001242"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001242"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001242; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001242]").text(description); $(".js-view-count[data-work-id=114001242]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001242; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001242']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001241"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001241/CD133_CD44_Cells_Mediate_in_the_Lung_Metastasis_of_Osteosarcoma"><img alt="Research paper thumbnail of CD133+CD44+Cells Mediate in the Lung Metastasis of Osteosarcoma" class="work-thumbnail" src="https://attachments.academia-assets.com/110815091/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001241/CD133_CD44_Cells_Mediate_in_the_Lung_Metastasis_of_Osteosarcoma">CD133+CD44+Cells Mediate in the Lung Metastasis of Osteosarcoma</a></div><div class="wp-workCard_item"><span>Journal of Cellular Biochemistry</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This article has been accepted for publication and undergone full peer review but has not been th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="329c8d843be047defa81ac0905b2823d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815091,"asset_id":114001241,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815091/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001241"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001241"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001241; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001241]").text(description); $(".js-view-count[data-work-id=114001241]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001241; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001241']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "329c8d843be047defa81ac0905b2823d" } } $('.js-work-strip[data-work-id=114001241]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001241,"title":"CD133+CD44+Cells Mediate in the Lung Metastasis of Osteosarcoma","internal_url":"https://www.academia.edu/114001241/CD133_CD44_Cells_Mediate_in_the_Lung_Metastasis_of_Osteosarcoma","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815091,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815091/thumbnails/1.jpg","file_name":"jcb.2513120240125-1-twfo6t.pdf","download_url":"https://www.academia.edu/attachments/110815091/download_file","bulk_download_file_name":"CD133_CD44_Cells_Mediate_in_the_Lung_Met.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815091/jcb.2513120240125-1-twfo6t-libre.pdf?1706152079=\u0026response-content-disposition=attachment%3B+filename%3DCD133_CD44_Cells_Mediate_in_the_Lung_Met.pdf\u0026Expires=1741342416\u0026Signature=Kg2yniCL8Hq~kv4BNOMqI3ntTDPiveigtjly-EVovZl7vO3TzJtkeznhxgwUcTDpbNXfh~t9zImfsQe18iSzeerFTvnkd3i-iCCTLePEu7HOHLiAqqNJxnZeAUkWgp-BJDdgeB9TXSmL~E1rIkEUcQSBdxmceIVrtuFoqpLcDLPLSHfZUVhBK4-0sYsPoZYcokTKpHo8ayMn4MzEzsNMArm19KoSDXPe880ls2GjTmFuRmLtd3Ed5Eh3rMe3vkLWaCyFRisz4OwXUt8wYO83pqa4VFn4Ct7mOuroblwOGrElNKCZX7kfdPSPlY66zl8ueOSwZpjVEunT-JvasZ~mHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001240"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001240/Reliable_cell_cycle_commitment_in_budding_yeast_is_ensured_by_signal_integration"><img alt="Research paper thumbnail of Reliable cell cycle commitment in budding yeast is ensured by signal integration" class="work-thumbnail" src="https://attachments.academia-assets.com/110815093/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001240/Reliable_cell_cycle_commitment_in_budding_yeast_is_ensured_by_signal_integration">Reliable cell cycle commitment in budding yeast is ensured by signal integration</a></div><div class="wp-workCard_item"><span>eLife</span><span>, Jan 15, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cell fate decisions are critical for life, yet little is known about how their reliability is ach...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We further identify the Start repressor, Whi5, as the integrator. The instantaneous kinase activity of Cln3-Cdk1 is recorded over time on the phosphorylated Whi5, and the decision is made only when phosphorylated Whi5 reaches a threshold. Cells adjust the threshold by modulating Whi5 concentration in different nutrient conditions to coordinate growth and division. Our work shows that the strategy of signal integration, which was previously found in decision-making behaviors of animals, is adopted at the cellular level to reduce noise and minimize uncertainty.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea52aaf831a6d9b518dd4e065aa74cd6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815093,"asset_id":114001240,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815093/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001240"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001240"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001240; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001240]").text(description); $(".js-view-count[data-work-id=114001240]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001240; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001240']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ea52aaf831a6d9b518dd4e065aa74cd6" } } $('.js-work-strip[data-work-id=114001240]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001240,"title":"Reliable cell cycle commitment in budding yeast is ensured by signal integration","internal_url":"https://www.academia.edu/114001240/Reliable_cell_cycle_commitment_in_budding_yeast_is_ensured_by_signal_integration","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815093,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815093/thumbnails/1.jpg","file_name":"elife-03977-v3.pdf","download_url":"https://www.academia.edu/attachments/110815093/download_file","bulk_download_file_name":"Reliable_cell_cycle_commitment_in_buddin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815093/elife-03977-v3-libre.pdf?1706152085=\u0026response-content-disposition=attachment%3B+filename%3DReliable_cell_cycle_commitment_in_buddin.pdf\u0026Expires=1741342416\u0026Signature=RmquG6jD6JyWxV-uSfuZDiEDUsmCCV8uB2t6gMSmTUi2MISkymbe1TrdIv3N0iwjKnjE3PgsvB9eh-jgZTkEpVbz8Pjeu9r~iXU~JddK3NtEFZXKgrzrg-de83tF1-9KsGlcROkV-bdtS~Iak29bdaGnfpIWVkAK2bd9WYcMpInTr73H-loZ4dzhezPjiaxFoY50zLvPaBIu6JfwXepF40oslW31O03-pQi3Tsm0vOY-2mo7OsQV1CkTbZ~sipSBjexUTRKvrk7MuZzvHpRrxINzuwAEhetKPnq6kwbB5Jq0N0~8kq5iQPTqekHG9GsJOIEH6Etxobxy6Od6RY-tOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001239"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001239/Integrative_epigenome_analysis_identifies_a_Polycomb_targeted_differentiation_program_as_a_tumor_suppressor_event_epigenetically_inactivated_in_colorectal_cancer"><img alt="Research paper thumbnail of Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/110815089/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001239/Integrative_epigenome_analysis_identifies_a_Polycomb_targeted_differentiation_program_as_a_tumor_suppressor_event_epigenetically_inactivated_in_colorectal_cancer">Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer</a></div><div class="wp-workCard_item"><span>Cell Death & Disease</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aberrant DNA hypermethylation in human cancer has been associated with Polycomb target genes in e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aberrant DNA hypermethylation in human cancer has been associated with Polycomb target genes in embryonic stem (ES) cells, but a functional link of the Polycomb-targeted differentiation program to tumorigenesis remains to be established. Here, through epigenome analysis correlating DNA hypermethylation in colon cancer with ES cell pluripotency and differentiation, we identified a set of DNA hypermethylated genes in cancer cells that are Polycomb targets strongly associated with ES cell differentiation, including HAND1, a developmental regulator. Intriguingly, HAND1 is silenced in over 90% of human primary colorectal tumors, and re-expression of HAND1 in colon cancer cells induces terminal differentiation, inhibits proliferation and prevents xenograft tumor formation. Moreover, hypermethylated HAND1 has a minimum enrichment of EZH2-H3K27me3 in cancer cells, but becomes EZH2 bound and bivalent upon the loss of DNA methylation, suggesting a sequential gene silencing event during oncogenesis. These findings established a functional role of Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in human cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efb0f8ab52b261e81e3e33c13eb2917f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815089,"asset_id":114001239,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815089/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001239"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001239"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001239; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001239]").text(description); $(".js-view-count[data-work-id=114001239]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001239; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001239']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "efb0f8ab52b261e81e3e33c13eb2917f" } } $('.js-work-strip[data-work-id=114001239]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001239,"title":"Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer","internal_url":"https://www.academia.edu/114001239/Integrative_epigenome_analysis_identifies_a_Polycomb_targeted_differentiation_program_as_a_tumor_suppressor_event_epigenetically_inactivated_in_colorectal_cancer","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815089,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815089/thumbnails/1.jpg","file_name":"cddis2014283.pdf","download_url":"https://www.academia.edu/attachments/110815089/download_file","bulk_download_file_name":"Integrative_epigenome_analysis_identifie.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815089/cddis2014283-libre.pdf?1706152078=\u0026response-content-disposition=attachment%3B+filename%3DIntegrative_epigenome_analysis_identifie.pdf\u0026Expires=1741342416\u0026Signature=EocwJISSD5viFU5TAXQ8~W0sj9jNWF6tewursg-R7bUMJgZzdsQomyvmm-TKnDQhuP97GDPmIEwo5mWt-TxJjqiOqWytIA1~qQ-FUCeaOZHJSKOflCVHTtl6Y~at1TeH5nSlUepUm3vupxiS92wywNTSGSKKcgo4gl1c0fCS7KDDm2AY24TpPIOziG3eoxgZvu41myFE2kibnizPNoe~esagD9fUQ~9U0bjJdF8u6OOxyslLh4yH-STx2p6h6vvJcy9btZIOJ6l--W0jXCyrq1SLs8H3hgr4rwSflvx1jW~R302UkoDus1MKIzMg353KobL7T1VBs8tTF9NTQgRD~w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001238"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001238/Role_of_EHD2_in_migration_and_invasion_of_human_breast_cancer_cells"><img alt="Research paper thumbnail of Role of EHD2 in migration and invasion of human breast cancer cells" class="work-thumbnail" src="https://attachments.academia-assets.com/110815092/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001238/Role_of_EHD2_in_migration_and_invasion_of_human_breast_cancer_cells">Role of EHD2 in migration and invasion of human breast cancer cells</a></div><div class="wp-workCard_item"><span>Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</span><span>, Jan 5, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Eps15 homology domain-containing 2 (EHD2) is a tumor suppressor gene, overexpressed in several so...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Eps15 homology domain-containing 2 (EHD2) is a tumor suppressor gene, overexpressed in several solid tumors, including ovarian cancer and esophageal squamous cell carcinoma. The current study examined the expression and the role of EHD2 in human breast cancer. EHD2 expression was determined by Western blot and immunohistochemistry (IHC) in 80 breast cancer and paired noncancerous breast tissues. Correlations between clinicopathologic variables, overall survival, and EHD2 expression were analyzed. We investigated the role of EHD2 in breast cancer migration and invasion by wound healing assay and trans-well invasion assays. A notably lower level of EHD2 expression was found in breast cancer tissues. EHD2 expression was associated with histological grade, lymph node metastasis, and tumor size. Expression of EHD2 was found to be an independent prognostic factor in breast cancer patients. Furthermore, overexpression of EHD2 suppressed, while elimination of EHD2 promoted, the migration an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="72f59a3cfb3ecd99fef314b665d1c0b3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815092,"asset_id":114001238,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815092/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001238"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001238"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001238; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001238]").text(description); $(".js-view-count[data-work-id=114001238]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001238; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001238']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "72f59a3cfb3ecd99fef314b665d1c0b3" } } $('.js-work-strip[data-work-id=114001238]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001238,"title":"Role of EHD2 in migration and invasion of human breast cancer cells","internal_url":"https://www.academia.edu/114001238/Role_of_EHD2_in_migration_and_invasion_of_human_breast_cancer_cells","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815092,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815092/thumbnails/1.jpg","file_name":"s13277-014-3011-920240125-1-ztfvy2.pdf","download_url":"https://www.academia.edu/attachments/110815092/download_file","bulk_download_file_name":"Role_of_EHD2_in_migration_and_invasion_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815092/s13277-014-3011-920240125-1-ztfvy2-libre.pdf?1706152077=\u0026response-content-disposition=attachment%3B+filename%3DRole_of_EHD2_in_migration_and_invasion_o.pdf\u0026Expires=1741342416\u0026Signature=PToA0aC2WqgOQWdR5tBVxuTe~rFd2mziHs6s9wjwPkJwtmCWF526HVPYvsIvxupIGV-x3qPPUyj~czTlcoURsQfxaVBELnEOeFzpUNDN3V2TSxHILrDLJl3Iyci5seI~DMxQDnp6QF2KiFg9uoJTRFGfZqfMkZej-h4fEPucqwiyzBJsU9cZg~4M1lvLy6QTBxW5ksTwEpug2rCDmuj5eeogjIn7Bd~Kx-iphIhh38glJl0UokvkPg1-~m9ogdniRlfYQkpBlufg7DL0PyPZ9pcmNJ5KktuQRjmtcHVna7fll45RZyB8k959oKccQmvgjXBq29Webqj3I8-pmat2Dg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001237"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001237/Low_expression_of_cyclic_AMP_response_element_modulator_1_can_increase_the_migration_and_invasion_of_esophageal_squamous_cell_carcinoma"><img alt="Research paper thumbnail of Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/110815107/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001237/Low_expression_of_cyclic_AMP_response_element_modulator_1_can_increase_the_migration_and_invasion_of_esophageal_squamous_cell_carcinoma">Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma</a></div><div class="wp-workCard_item"><span>Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cyclic AMP response element-binding protein (CREB) family can regulate biological functions of va...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cyclic AMP response element-binding protein (CREB) family can regulate biological functions of various types of cells and has relation with esophageal cancer cell migration and invasion. Cyclic AMP response element modulator-1 (CREM-1) is one member of the family with limited acquaintance. This study was conducted to investigate the effect of CREM-1 on migration and invasion in human esophageal squamous cell carcinoma (ESCC). The expression of CREM-1 protein in ESCC tissues with or without lymph nodes metastasis was determined by western blot. Immunohistochemical analysis of CREM-1 expression were carried out in paraffin-embedded sections of ESCC and correlated with clinical features. The roles of CREM-1 in migration and invasion were studied in TE1 cells through knocking CREM-1 down with siRNA or overexpression of CREM-1 in ECA109 cells. The regulations of CREM-1 on invasion and migration were determined by transwell and wounding healing assay. The effect of CREM-1 on chemotherapy ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9fbd0c2fbed6ef8b2d3305827be4b6ac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815107,"asset_id":114001237,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815107/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001237"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001237"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001237; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114001237]").text(description); $(".js-view-count[data-work-id=114001237]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114001237; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114001237']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9fbd0c2fbed6ef8b2d3305827be4b6ac" } } $('.js-work-strip[data-work-id=114001237]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114001237,"title":"Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma","internal_url":"https://www.academia.edu/114001237/Low_expression_of_cyclic_AMP_response_element_modulator_1_can_increase_the_migration_and_invasion_of_esophageal_squamous_cell_carcinoma","owner_id":300557083,"coauthors_can_edit":true,"owner":{"id":300557083,"first_name":"xiaojing","middle_initials":null,"last_name":"yang","page_name":"xiaojingyang13","domain_name":"independent","created_at":"2024-01-24T18:47:38.010-08:00","display_name":"xiaojing yang","url":"https://independent.academia.edu/xiaojingyang13"},"attachments":[{"id":110815107,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110815107/thumbnails/1.jpg","file_name":"s13277-013-0946-120240125-1-r3vs5a.pdf","download_url":"https://www.academia.edu/attachments/110815107/download_file","bulk_download_file_name":"Low_expression_of_cyclic_AMP_response_el.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110815107/s13277-013-0946-120240125-1-r3vs5a-libre.pdf?1706152074=\u0026response-content-disposition=attachment%3B+filename%3DLow_expression_of_cyclic_AMP_response_el.pdf\u0026Expires=1741342416\u0026Signature=eKN7laKie3YCnBuz1oBRiH7FcV-noTgpXy639QMB8DRcm6ghwXd2aDGcPjZalO8nnHi2FWmpV9uMa~L5yVtEZL0MOOouS0CzJh4MjreQwtSjPSsSpfrhyuzz42xuk1tjvQIHZgT97gbSibNeaiAdkJzFZzrL5xsiAqOg1F5edYStR32NrRLeFytSqQ2pJFL4kS7PCmKmBqto87enccJh3cpvc04Dncbqp5rzN5~Grf0D1YUi45SjFZN8n0ctRD5pUPf-LGF2B-mpmXznfPx-3AGsDTOZ2WuRsz55YIWgXqHd4U9y5aDn1J7hBpvZ2l25ocCpEXOAMR-qwTDw1fsOmA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001236"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114001236/Gene_body_methylation_can_alter_gene_expression_and_is_a_therapeutic_target_in_cancer"><img alt="Research paper thumbnail of Gene body methylation can alter gene expression and is a therapeutic target in cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/110815099/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114001236/Gene_body_methylation_can_alter_gene_expression_and_is_a_therapeutic_target_in_cancer">Gene body methylation can alter gene expression and is a therapeutic target in cancer</a></div><div class="wp-workCard_item"><span>Cancer cell</span><span>, Jan 13, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">DNA methylation in promoters is well known to silence genes and is the presumed therapeutic targe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">DNA methylation in promoters is well known to silence genes and is the presumed therapeutic target of methylation inhibitors. Gene body methylation is positively correlated with expression, yet its function is unknown. We show that 5-aza-2&#39;-deoxycytidine treatment not only reactivates genes but decreases the overexpression of genes, many of which are involved in metabolic processes regulated by c-MYC. Downregulation is caused by DNA demethylation of the gene bodies and restoration of high levels of expression requires remethylation by DNMT3B. Gene body methylation may, therefore, be an unexpected therapeutic target for DNA methylation inhibitors, resulting in the normalization of gene overexpression induced during carcinogenesis. Our results provide direct evidence for a causal relationship between gene body methylation and transcription.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cdd18d4b693c72789b3a5c5ce9a5d528" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110815099,"asset_id":114001236,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110815099/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001236"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001236"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001236; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114001235"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114001235/A_low_level_of_GPR37_is_associated_with_human_hepatocellular_carcinoma_progression_and_poor_patient_survival"><img alt="Research paper thumbnail of A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114001235/A_low_level_of_GPR37_is_associated_with_human_hepatocellular_carcinoma_progression_and_poor_patient_survival">A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival</a></div><div class="wp-workCard_item"><span>Pathology, research and practice</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR). It has been reported that GPCRs play vital roles in the development and progression of cancer. To investigate the potential roles of GPR37 in hepatocellular carcinoma (HCC), expression of GPR37 was examined in human HCC samples. Immunohistochemistry and Western blot analyses were performed for GPR37 in 57 hepatocellular carcinoma samples. GPR37 expression was low in hepatocellular carcinoma as compared with the adjacent non-tumorous tissues. Clinicopathological analysis showed that GPR37 expression was significantly correlated with histological grade and the level of alpha fetal protein (AFP) (P = 0.000 and 0.002, respectively). The Kaplan-Meier survival curves revealed that decreasing GPR37 expression was associated with poor prognosis in HCC patients, while in vitro, following the release from serum starvation of HuH7 HCC cell, the expression of GPR37 was downr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114001235"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114001235"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114001235; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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