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Jesus Araujo | UCLA Fielding
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class="secondary-nav__link"> Give </a> </li> </ul> </nav> </div> </div> <div class="off-canvas-bar__close"> <a href="#" class="menu-close" id="menu-close"> <span class="show-for-sr">Close Menu</span> <svg class="brei-icon brei-icon-close" focusable="false"><use xlink:href="#brei-icon-close" /> </svg> </a> </div> </div> </header> <main id="main" class="level"> <section id="masthead" class="masthead"> <div class="masthead__wrapper"> <div class="masthead__inner"> <div class="masthead__content"> <h1 class="masthead__heading">Jesus Araujo</h1> </div></div> </div> </section> <div class="level__wrapper"> <div class="row column breadcrumbs__wrapper"> <nav class="breadcrumbs"> <ul> <li class="breadcrumbs__item breadcrumbs__item--home"> <a href="/" title="Home Page"><span class='show-for-sr'>Home Page</span><svg class='brei-icon brei-icon-home' focusable='false'><use xlink:href='#brei-icon-home'></use></svg></a> <svg class="brei-icon brei-icon-chevron" focusable="false"><use xlink:href="#brei-icon-chevron" /> </svg> </li> <li class="breadcrumbs__item"> <a href="/about" class="breadcrumbs__link">About</a> <svg class="brei-icon brei-icon-chevron" focusable="false"><use xlink:href="#brei-icon-chevron" /> </svg> </li> <li class="breadcrumbs__item"> <a href="/about/faculty-staff-directory" class="breadcrumbs__link">Faculty & Staff Directory</a> <svg class="brei-icon brei-icon-chevron" focusable="false"><use xlink:href="#brei-icon-chevron" /> </svg> </li> <li class="breadcrumbs__item breadcrumbs__item--current"> <span class="breadcrumbs__span">Jesus Araujo</span> </li> </ul> </nav> </div> <div class="row level__row"> <div class="level__content large-8 large-push-4 columns"> <div data-drupal-messages-fallback class="hidden"></div> <div class="user-markup"> <p>The main research interest of Dr. Jesus Araujo's lab are focused on two areas of investigation:</p> <p>Environmental Cardiology: We are dissecting the mechanism by which exposure to air particulate matter promotes atherosclerosis and ischemic heart disease and studying gene-environment interactions of relevance in the development of cardiovascular disease. In recent years, we have found that air pollutant chemicals such as those present in diesel exhaust particle air are able to synergize with oxidized phospholipids generated within oxidated LDL, in the promotion of proatherogenic genes in vascular endothelial cells. We have also determined that inhalation of ambient ultrafine particle lead to systemic prooxidant and proinflammatory effects that result in the development of dysfunctional HDL and enhancement of atheroscleorotic leisons. </p> <p>Biology of vascular oxidative stress: We are interested in genes and pathways of relevance in the oxidative stress generated in vascular inflammatory entities such as atherosclerosis and ischemia reperfusion. We have determined that heme oxygenase-1(HO-1) is an important antioxidant and anti-inflammatory protective gene and together with transcriptional regulator Nrf2, they may play a central role in orchestrating the antioxidant defense of vascular cells. However, while HO-1 is anti-atherogenic gene, NrF2 promotes atherosclerosis instead partly due to the regulation of genes involved in lipid metabolism and cholesterol transport. This underscores the complexity of reactive oxygen species (ROS) signaling in vascular cells. We are currently studying how HO-1 expression modulates various inflammatory pathways via the use of genetic and biochemical approaches.</p> </div> <div class="education user-markup"> <h2>Education</h2> <hr/> <ul> <li>PhD, Molecular Biology, Molecular Biology Institute, University of California, Los Angeles, CA</li> <li>MD, Central University of Venezuela, Caracas, Venezuela</li> <li>MSc, Immunology, Venezuela Institute for Scientific Research, Venezuela</li> </ul> </div> <div class="related-tags"> <div class="related-tags__inner"> <h2>Related Tags</h2> <ul class="related-tags__list"> <li class="related-tags__item"> <a href="/about/faculty-staff-directory?department[]=87" class="btn btn--primary"> <span class="text">Environmental Health Sciences</span> </a> </li> </ul> </div> </div> <div class="user-markup"> <h2>Selected Publications</h2> <hr/> <ul> <li>Araujo JA, Meng L, Tward A, Hancock WW, Zhai Y, Lee A, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol 2003: 171: 1572-80.</li> <li>Tsuchihashi SI, Livhits M, Zhai Y, Bussutil RW, Araujo JA, Kupiec-Weglinski JW. Basal rather than induced HO-1 levels are crucial in the antioxidant cytoprotection. J Immunol 2006, 177: 4749-57.</li> <li>Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih D, Agarwal A, Lusis AJ, Araujo JA. Heme oxygenase-1 expression in macrophages plays a beneficial role against atherosclerosis. Circ Research 2007; 100: 1703-1711.</li> <li>Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA. Air pollutant chemicals and oxidized lipids exhibit genome wide synergistic effects on endothelial cells. Genome Biology 2007; 8: R149.</li> <li>Araujo JA, Barajas B, Kleinman M, Wang X, Bennett B, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel A. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Research 2008; 102.</li> </ul> </div> </div> <aside class="level__aside large-3 large-pull-9 columns"> <div class="contact-info"> <figure class="contact-info__image"> <img src="https://ph.ucla.edu/sites/default/files/styles/large/public/2022-07/person-placeholder.jpg?itok=Yj28CoTl" alt="Faculty/staff profile placeholder image"/> </figure> <div class="contact-info__content"> <h2 class="contact-info__title">Dr. Jesus Araujo</h2> <div class="contact-info__inner"> <h3 class="contact-info__heading">Department(s)</h3> <div class="contact-info__labels"> <span class="info-label green"> Environmental Health Sciences </span> </div> <h3 class="contact-info__heading">Title(s)</h3> <ul class="contact-info__list"> <li class="contact-info__item">Associate Professor of Environmental Health Sciences</li> <li class="contact-info__item"></li> <li class="contact-info__item"></li> <li class="contact-info__item"></li> <li class="contact-info__item"></li> </ul> <h3 class="contact-info__heading">Contact Info</h3><p class="contact-info__copy"> Room 43-264 CHS </p> <ul class="contact-info__info"> <li class="contact-info__item"> <a href="mailto:jaraujo@mednet.ucla.edu" class="menu-secondary"> <span class="text">jaraujo@<wbr/>mednet.ucla.edu</span> <span class="chevron"><svg class="brei-icon brei-icon-chevron" focusable="false"><use xlink:href="#brei-icon-chevron" /> </svg> </span> </a> </li> <li class="contact-info__item"> <a href="tel:310.825.3222" class="menu-secondary"> <span class="text">310.825.3222</span> <span class="chevron"><svg class="brei-icon brei-icon-chevron" focusable="false"><use xlink:href="#brei-icon-chevron" /> </svg> </span> </a> </li> </ul> </div> </div> </div> <div class="rail-callout"> <div class="rail-callout__content"> </div> <ul class="rail-callout__list"> <li class="rail-callout__item"> <a href="https://people.healthsciences.ucla.edu/institution/personnel?personnel_id=35218" class="btn btn--primary btn--with-icon"> <span class="text">David Geffen School of Medicine Profile</span> <span class="btn__icon"><svg class="brei-icon brei-icon-external" focusable="false"><use xlink:href="#brei-icon-external" /> </svg> </span> </a> </li> </ul> </div> </aside> </div> </div> </main> <footer id="js-global-footer" class="global-footer"> <div class="global-footer__row"> <div class="global-footer__wrapper"> <div class="global-footer__contact"> <a href="/" class="logo"> <span class="show-for-sr">Return to home</span> <svg class="brei-icon brei-icon-logo-white" focusable="false"><use xlink:href="#brei-icon-logo-white" /> </svg> </a> <nav id="footer-nav" class="footer-nav" aria-label="Footer Navigation"> <ul class="footer-nav__list clearfix" role="menubar"> <li class="footer-nav__item" role="menuitem"> <a href="/alumni" class="menu-primary footer-nav__link"> Alumni </a> </li> <li class="footer-nav__item" role="menuitem"> <a href="/about/faculty-staff-directory" class="menu-primary footer-nav__link"> Faculty & Staff Directory </a> </li> <li class="footer-nav__item" role="menuitem"> <a href="/about/administrative-offices/office-human-resources/employment-opportunities" class="menu-primary footer-nav__link"> Employment Opportunities </a> </li> <li class="footer-nav__item" role="menuitem"> <a href="/about/administrative-offices/office-marketing-communications/media-resources" class="menu-primary footer-nav__link"> Media Resources </a> </li> <li class="footer-nav__item" role="menuitem"> <a href="/subscriptions" class="menu-primary footer-nav__link"> Subscriptions </a> </li> </ul> </nav> <div class="social-links"> <ul class="social-links__list" role="menubar"> <li class="social-links__item" role="menuitem"> <a href="http://instagram.com/uclafsph" class="btn btn--social"> <span class="btn__icon"><svg class="brei-icon brei-icon-instagram" focusable="false"><use xlink:href="#brei-icon-instagram" /> </svg> </span> <span class="show-for-sr">Follow us on Instagram</span> </a> </li> <li class="social-links__item" role="menuitem"> <a href="http://facebook.com/pages/UCLA-Fielding-School-of-Public-Health/31467516815" class="btn btn--social"> <span class="btn__icon"><svg class="brei-icon brei-icon-facebook" focusable="false"><use xlink:href="#brei-icon-facebook" /> </svg> </span> <span class="show-for-sr">Find us on Facebook</span> </a> </li> <li class="social-links__item" role="menuitem"> <a href="https://www.linkedin.com/school/fsph/" class="btn btn--social"> <span class="btn__icon"><svg class="brei-icon brei-icon-linkedin" focusable="false"><use xlink:href="#brei-icon-linkedin" /> </svg> </span> <span class="show-for-sr">Find us on LinkedIn</span> </a> </li> </ul> </div> <address class="global-footer__address vcard"> <span class="adr"> <span class="street-address"> <span class="line-1">650 Charles E. 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