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class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein found in humans</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="/wiki/Calreticulin" title="Calreticulin">calreticulin</a>.</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CALB2</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/1435">CALB2</a></span>, CAB29, CAL2, CR, calbindin 2</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/114051">114051</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:101914">101914</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1318">1318</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CALB2">CALB2</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000172137">CALB2 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_16.svg" class="mw-file-description" title="Chromosome 16 (human)"><img alt="Chromosome 16 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/450px-Ideogram_human_chromosome_16.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/600px-Ideogram_human_chromosome_16.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_16_(human)" class="mw-redirect" title="Chromosome 16 (human)">Chromosome 16 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_16_ideogram.svg" class="mw-file-description" title="Chromosome 16 (human)"><img alt="Chromosome 16 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/300px-Human_chromosome_16_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/450px-Human_chromosome_16_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/600px-Human_chromosome_16_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 226.98893734796px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CALB2"><img alt="Genomic location for CALB2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 233px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CALB2"><img alt="Genomic location for CALB2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">16q22.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">71,358,713 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">71,390,436 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (mouse)"><img alt="Chromosome 8 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/260px-Ideogram_house_mouse_chromosome_8.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/390px-Ideogram_house_mouse_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/520px-Ideogram_house_mouse_chromosome_8.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 8 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (mouse)"><img alt="Chromosome 8 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/300px-Ideogram_of_house_mouse_chromosome_8.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/450px-Ideogram_of_house_mouse_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/600px-Ideogram_of_house_mouse_chromosome_8.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 246.63271177838px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CALB2"><img alt="Genomic location for CALB2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 252.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CALB2"><img alt="Genomic location for CALB2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">8|8 D3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">110,864,134 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">110,894,842 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000172137">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">hypothalamus</li><br /><li style="line-height: 137%;">right hemisphere of cerebellum</li><br /><li style="line-height: 137%;">subcutaneous adipose tissue</li><br /><li style="line-height: 137%;">right adrenal gland</li><br /><li style="line-height: 137%;">right adrenal cortex</li><br /><li style="line-height: 137%;">left adrenal cortex</li><br /><li style="line-height: 137%;">temporal lobe</li><br /><li style="line-height: 137%;">amygdala</li><br /><li style="line-height: 137%;">anterior cingulate cortex</li><br /><li style="line-height: 137%;">substantia nigra</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000003657">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">habenula</li><br /><li style="line-height: 137%;">vestibular membrane of cochlear duct</li><br /><li style="line-height: 137%;">neural layer of retina</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li><br /><li style="line-height: 137%;">olfactory bulb</li><br /><li style="line-height: 137%;">cerebellar cortex</li><br /><li style="line-height: 137%;">ventral tegmental area</li><br /><li style="line-height: 137%;">lobe of cerebellum</li><br /><li style="line-height: 137%;">central gray substance of midbrain</li><br /><li style="line-height: 137%;">ventromedial nucleus</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000172137">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099534">calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043005">neuron projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005921">gap junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045202">synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097060">synaptic membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098688">parallel fiber to Purkinje cell synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098793">presynapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030425">dendrite</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032420">stereocilium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032437">cuticular plate</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051480">regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099509">regulation of presynaptic cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900271">regulation of long-term synaptic potentiation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=794&rn=1">794</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12308&rn=1">12308</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000172137;db=core">ENSG00000172137</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000282830;db=core">ENSG00000282830</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000003657;db=core">ENSMUSG00000003657</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P22676">P22676</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q08331">Q08331</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001740">NM_001740</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007087">NM_007087</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007088">NM_007088</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007586">NM_007586</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001368293">NM_001368293</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001368294">NM_001368294</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001731">NP_001731</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_009019">NP_009019</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031612">NP_031612</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001355222">NP_001355222</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001355223">NP_001355223</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr16:71358713-71390436">Chr 16: 71.36 – 71.39 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr8:110864134-110894842">Chr 8: 110.86 – 110.89 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14908072" class="extiw" title="d:Q14908072">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14908073" class="extiw" title="d:Q14908073">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg/220px-Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg/330px-Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/55/Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg/440px-Malignant_epithelioid_mesothelioma_-_calretinin_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848" /></a><figcaption> <a href="/wiki/Micrograph" title="Micrograph">Micrograph</a> of a malignant epithelioid <a href="/wiki/Mesothelioma" title="Mesothelioma">mesothelioma</a> stained with an antibody against calretinin</figcaption></figure> <p><b>Calretinin</b>, also known as <b>calbindin 2</b> (formerly <b>29 kDa calbindin</b>), is a <a href="/wiki/Calcium-binding_protein" title="Calcium-binding protein">calcium-binding protein</a> involved in <a href="/wiki/Calcium_signaling" title="Calcium signaling">calcium signaling</a>.<sup id="cite_ref-pmid3654755_5-0" class="reference"><a href="#cite_note-pmid3654755-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In humans, the calretinin protein is encoded by the <i>CALB2</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1906795_7-0" class="reference"><a href="#cite_note-pmid1906795-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>This gene encodes an intracellular calcium-binding protein belonging to the <a href="/wiki/Troponin_C" title="Troponin C">troponin C</a> superfamily. Members of this protein family have six <a href="/wiki/EF_hand" title="EF hand">EF-hand</a> domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering.<sup id="cite_ref-entrez_6-1" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Calretinin is abundantly expressed in neurons including retina (which gave it the name)<sup id="cite_ref-pmid3654755_5-1" class="reference"><a href="#cite_note-pmid3654755-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> and cortical <a href="/wiki/Interneurons" class="mw-redirect" title="Interneurons">interneurons</a>.<sup id="cite_ref-pmid20406030_8-0" class="reference"><a href="#cite_note-pmid20406030-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Expression was found in different neurons than that of the similar <a href="/wiki/Vitamin_D-dependent_calcium-binding_protein" class="mw-redirect" title="Vitamin D-dependent calcium-binding protein">vitamin D-dependent calcium-binding protein</a>, <a href="/wiki/Calbindin" title="Calbindin">calbindin</a>-28kDa.<sup id="cite_ref-pmid3654755_5-2" class="reference"><a href="#cite_note-pmid3654755-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Calretinin has an important role as a modulator of neuronal excitability including the induction of <a href="/wiki/Long-term_potentiation" title="Long-term potentiation">long-term potentiation</a>.<sup id="cite_ref-pmid19450707_9-0" class="reference"><a href="#cite_note-pmid19450707-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Loss of expression of calretinin in hippocampal interneurons has been suggested to be relevant in temporal lobe epilepsy.<sup id="cite_ref-pmid25324731_10-0" class="reference"><a href="#cite_note-pmid25324731-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>It is expressed in a number of other locations including hair follicles.<sup id="cite_ref-pmid15948999_11-0" class="reference"><a href="#cite_note-pmid15948999-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=2" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Calretinin is a diagnostic marker for some human diseases, including <a href="/wiki/Hirschsprung_disease" class="mw-redirect" title="Hirschsprung disease">Hirschsprung disease</a> and some cancers. </p> <div class="mw-heading mw-heading3"><h3 id="Mesothelioma">Mesothelioma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=3" title="Edit section: Mesothelioma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Using <a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">immunohistochemistry</a>, calretinin can be demonstrated in both benign <a href="/wiki/Mesothelium" title="Mesothelium">mesothelium</a> and in malignant <a href="/wiki/Mesothelioma" title="Mesothelioma">mesothelioma</a><sup id="cite_ref-pmid11299732_12-0" class="reference"><a href="#cite_note-pmid11299732-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> and can be used to help differentiate different <a href="/wiki/Lung_cancer" title="Lung cancer">lung tumours</a>.<sup id="cite_ref-pmid18318582_14-0" class="reference"><a href="#cite_note-pmid18318582-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Antibodies to calretinin can also be used to distinguish between different types of <a href="/wiki/Brain_tumour" class="mw-redirect" title="Brain tumour">brain tumour</a>, demonstrating only those with <a href="/wiki/Neuron" title="Neuron">neuronal</a> rather than <a href="/wiki/Neuroglia" class="mw-redirect" title="Neuroglia">glial</a>, differentiation.<sup id="cite_ref-Leong_15-0" class="reference"><a href="#cite_note-Leong-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Furthermore, the essential function of calretinin in mesothelioma cell lines has been demonstrated <i>in vitro</i> and may be an interesting target for therapeutical approaches.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Hirschsprung_disease">Hirschsprung disease</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=4" title="Edit section: Hirschsprung disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In <a href="/wiki/Hirschsprung_disease" class="mw-redirect" title="Hirschsprung disease">Hirschsprung disease</a>, calretinin <a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">immunohistochemistry</a> offers additional diagnostic value in specimens with inadequate amount of <a href="/wiki/Submucosa" title="Submucosa">submucosa</a> and rarely seen <a href="/wiki/Ganglion" title="Ganglion">ganglion</a> cells. The presence of ganglion cells consistently correlated with calretinin-positive thin nerve fibrils in the <a href="/wiki/Lamina_propria" title="Lamina propria">lamina propria</a>, <a href="/wiki/Muscularis_mucosae" title="Muscularis mucosae">muscularis mucosae</a> and superficial submucosa. These calretinin-positive thin <a href="/wiki/Neurofibril" class="mw-redirect" title="Neurofibril">neurofibrils</a> are absent in the aganglionic segments of <a href="/wiki/Bowel" class="mw-redirect" title="Bowel">bowel</a> and in the areas without ganglion cells from the junction of normal with diseased <a href="/wiki/Rectum" title="Rectum">rectum</a>. Calretinin is strongly expressed in the submucosal and <a href="/wiki/Subserosa" title="Subserosa">subserosal</a> nerve trunks in the ganglionic segment. No calretinin expression is seen in the nerve trunks in the rest of the aganglionic segment. It has faint expression in the thick nerve trunks from the areas without ganglion cells. Faint positivity of the thick submucosal and subserosal nerves in the absence of ganglion cells and calretinin positive nerve fibrils, is characteristic of the junction of the aganglionic-to-normal rectum.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a 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href="https://pubmed.ncbi.nlm.nih.gov/24294384">24294384</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Clinical+and+Experimental+Pathology&rft.atitle=Role+of+calretinin+immunohistochemical+stain+in+evaluation+of+Hirschsprung+disease%3A+an+institutional+experience&rft.volume=6&rft.issue=12&rft.pages=2955-61&rft.date=2013&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3843278%23id-name%3DPMC&rft_id=info%3Apmid%2F24294384&rft.aulast=Alexandrescu&rft.aufirst=S&rft.au=Rosenberg%2C+H&rft.au=Tatevian%2C+N&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3843278&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACalretinin" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=6" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAlaeddiniEtemad-MoghadamBaghaii2008" class="citation journal cs1">Alaeddini M, Etemad-Moghadam S, Baghaii F (Feb 2008). "Comparative expression of calretinin in selected odontogenic tumours: a possible relationship to histogenesis". <i>Histopathology</i>. <b>52</b> (3): 299–304. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2559.2007.02948.x">10.1111/j.1365-2559.2007.02948.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18269580">18269580</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:205299356">205299356</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Histopathology&rft.atitle=Comparative+expression+of+calretinin+in+selected+odontogenic+tumours%3A+a+possible+relationship+to+histogenesis&rft.volume=52&rft.issue=3&rft.pages=299-304&rft.date=2008-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A205299356%23id-name%3DS2CID&rft_id=info%3Apmid%2F18269580&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2559.2007.02948.x&rft.aulast=Alaeddini&rft.aufirst=M&rft.au=Etemad-Moghadam%2C+S&rft.au=Baghaii%2C+F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACalretinin" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGuinard-SamuelBonnardDe_LagausiePhilippe-Chomette2009" class="citation journal cs1">Guinard-Samuel V, Bonnard A, De Lagausie P, Philippe-Chomette P, Alberti C, El Ghoneimi A, Peuchmaur M, Berrebi-Binczak D (Oct 2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.2009.110">"Calretinin immunohistochemistry: a simple and efficient tool to diagnose Hirschsprung disease"</a>. <i>Modern Pathology</i>. <b>22</b> (10): 1379–84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.2009.110">10.1038/modpathol.2009.110</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19648883">19648883</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:643637">643637</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Modern+Pathology&rft.atitle=Calretinin+immunohistochemistry%3A+a+simple+and+efficient+tool+to+diagnose+Hirschsprung+disease&rft.volume=22&rft.issue=10&rft.pages=1379-84&rft.date=2009-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A643637%23id-name%3DS2CID&rft_id=info%3Apmid%2F19648883&rft_id=info%3Adoi%2F10.1038%2Fmodpathol.2009.110&rft.aulast=Guinard-Samuel&rft.aufirst=V&rft.au=Bonnard%2C+A&rft.au=De+Lagausie%2C+P&rft.au=Philippe-Chomette%2C+P&rft.au=Alberti%2C+C&rft.au=El+Ghoneimi%2C+A&rft.au=Peuchmaur%2C+M&rft.au=Berrebi-Binczak%2C+D&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fmodpathol.2009.110&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACalretinin" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSeressAbrahámCzéhFuchs2008" class="citation journal cs1">Seress L, Abrahám H, Czéh B, Fuchs E, Léránth C (2008). 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"Accessory liver lobe with mesothelial inclusion cysts in an omphalocele: a new malformative association". <i>Pediatric and Developmental Pathology</i>. <b>10</b> (3): 224–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2350%2F06-08-0148.1">10.2350/06-08-0148.1</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17535091">17535091</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:41971082">41971082</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pediatric+and+Developmental+Pathology&rft.atitle=Accessory+liver+lobe+with+mesothelial+inclusion+cysts+in+an+omphalocele%3A+a+new+malformative+association&rft.volume=10&rft.issue=3&rft.pages=224-8&rft.date=2007&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A41971082%23id-name%3DS2CID&rft_id=info%3Apmid%2F17535091&rft_id=info%3Adoi%2F10.2350%2F06-08-0148.1&rft.aulast=Rougemont&rft.aufirst=AL&rft.au=Sartelet%2C+H&rft.au=Oligny%2C+LL&rft.au=Bensoussan%2C+A&rft.au=Yazbeck%2C+S&rft.au=Fournet%2C+JC&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACalretinin" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFClementsMcDonoughFreeman2008" class="citation journal cs1">Clements RJ, McDonough J, Freeman EJ (May 2008). "Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue". <i>Experimental Brain Research</i>. <b>187</b> (3): 459–65. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00221-008-1317-9">10.1007/s00221-008-1317-9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18297277">18297277</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:18256420">18256420</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Experimental+Brain+Research&rft.atitle=Distribution+of+parvalbumin+and+calretinin+immunoreactive+interneurons+in+motor+cortex+from+multiple+sclerosis+post-mortem+tissue&rft.volume=187&rft.issue=3&rft.pages=459-65&rft.date=2008-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A18256420%23id-name%3DS2CID&rft_id=info%3Apmid%2F18297277&rft_id=info%3Adoi%2F10.1007%2Fs00221-008-1317-9&rft.aulast=Clements&rft.aufirst=RJ&rft.au=McDonough%2C+J&rft.au=Freeman%2C+EJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACalretinin" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calretinin&action=edit&section=7" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> 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channel">N</a></li> <li><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P</a></li> <li><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R</a></li> <li><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T</a></li></ul></li> <li><a href="/wiki/Transient_receptor_potential_channel" title="Transient receptor potential channel">TRP channels</a> <ul><li><a href="/wiki/TRPA_(ion_channel)" title="TRPA (ion channel)">TRPA</a></li> <li><a href="/wiki/TRPC" title="TRPC">TRPC</a></li> <li><a href="/wiki/TRPV" title="TRPV">TRPV</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ion_transporter" title="Ion transporter">Calcium pumps</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Sodium-calcium exchangers</a> <ul><li><a href="/wiki/SLC3A2" class="mw-redirect" title="SLC3A2">SLC3A2</a></li> <li><a href="/wiki/SLC8A1" class="mw-redirect" title="SLC8A1">SLC8A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/GPCR" class="mw-redirect" title="GPCR">GPCRs</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-sensing_receptor" title="Calcium-sensing receptor">Calcium-sensing receptor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Annexin" title="Annexin">Annexins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Annexin_A1" title="Annexin A1">A1</a></li> <li><a href="/wiki/Annexin_A2" title="Annexin A2">A2</a></li> <li><a href="/wiki/Annexin_A3" title="Annexin A3">A3</a></li> <li><a href="/wiki/Annexin_A4" title="Annexin A4">A4</a></li> <li><a href="/wiki/Annexin_A5" title="Annexin A5">A5</a></li> <li><a href="/wiki/Annexin_A6" title="Annexin A6">A6</a></li> <li><a href="/wiki/Annexin_A7" title="Annexin A7">A7</a></li> <li><a href="/w/index.php?title=Annexin_A8&action=edit&redlink=1" class="new" title="Annexin A8 (page does not exist)">A8</a></li> <li><a href="/wiki/ANXA8L2" title="ANXA8L2">A8-L2</a></li> <li><a href="/wiki/Annexin_A9" title="Annexin A9">A9</a></li> <li><a href="/w/index.php?title=Annexin_A10&action=edit&redlink=1" class="new" title="Annexin A10 (page does not exist)">A10</a></li> <li><a href="/wiki/Annexin_A11" title="Annexin A11">A11</a></li> <li><a href="/w/index.php?title=Annexin_A12&action=edit&redlink=1" class="new" title="Annexin A12 (page does not exist)">A12</a></li> <li><a href="/wiki/Annexin_A13" title="Annexin A13">A13</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular <a href="/wiki/Signal_transduction" title="Signal transduction">signaling</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Second_messengers" class="mw-redirect" title="Second messengers">Second messengers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_triphosphate" class="mw-redirect" title="Inositol triphosphate">IP3</a></li> <li><a href="/wiki/Nicotinic_acid_adenine_dinucleotide_phosphate" title="Nicotinic acid adenine dinucleotide phosphate">NAADP</a></li> <li><a href="/wiki/Cyclic_ADP-ribose" title="Cyclic ADP-ribose">cADPR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ryanodine-Inositol_1,4,5-triphosphate_receptor_calcium_channels" title="Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels">Intracellular channels</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_trisphosphate_receptor" title="Inositol trisphosphate receptor">IP3 receptor</a></li> <li><a href="/wiki/Ryanodine_receptor" title="Ryanodine receptor">Ryanodine receptor</a> <ul><li><a href="/wiki/Calcium-induced_calcium_release" title="Calcium-induced calcium release">Calcium-induced calcium release</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular pumps</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SERCA" title="SERCA">SERCA</a> <ul><li><a href="/wiki/ATP2A1" title="ATP2A1">ATP2A1</a></li> <li><a href="/wiki/ATP2A2" title="ATP2A2">ATP2A2</a></li> <li><a href="/wiki/ATP2A3" title="ATP2A3">ATP2A3</a></li></ul></li> <li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Sodium-calcium exchangers</a> <ul><li><a href="/wiki/SLC8B1" title="SLC8B1">SLC8B1</a></li> <li><a href="/wiki/SLC24A5" class="mw-redirect" title="SLC24A5">SLC24A5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Intracellular_calcium-sensing_proteins" title="Intracellular calcium-sensing proteins">Sensors</a> and <a href="/wiki/Chelator" class="mw-redirect" title="Chelator">chelators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calbindin" title="Calbindin">Calbindin</a></li> <li><a href="/wiki/Calmodulin" title="Calmodulin">Calmodulin</a> <ul><li><a href="/wiki/CALM1" class="mw-redirect" title="CALM1">CALM1</a></li> <li><a href="/wiki/CALM2" title="CALM2">CALM2</a></li> <li><a href="/wiki/CALM3" title="CALM3">CALM3</a></li> <li><a href="/wiki/CALML3" title="CALML3">CALML3</a></li> <li><a href="/wiki/CALML5" title="CALML5">CALML5</a></li></ul></li> <li><a href="/wiki/Calsequestrin" title="Calsequestrin">Calsequestrin</a></li> <li><a class="mw-selflink selflink">Calretinin</a></li> <li><a href="/wiki/Gelsolin" title="Gelsolin">Gelsolin</a></li> <li><a href="/wiki/Neuronal_calcium_sensor" title="Neuronal calcium sensor">Neuronal calcium sensors</a> <ul><li><a href="/wiki/Calsenilin" title="Calsenilin">Calsenilin</a></li> <li><a href="/wiki/Frequenin" class="mw-redirect" title="Frequenin">Frequenin</a></li> <li><a href="/wiki/Guanylate_cyclase_activator" title="Guanylate cyclase activator">GUCA</a> <ul><li><a href="/wiki/GUCA1A" title="GUCA1A">1A</a></li> <li><a href="/wiki/GUCA1B" title="GUCA1B">1B</a></li></ul></li> <li><a href="/wiki/Hippocalcin" title="Hippocalcin">Hippocalcin</a></li> <li><a href="/wiki/Neurocalcin" title="Neurocalcin">Neurocalcin</a></li> <li><a href="/wiki/Recoverin" title="Recoverin">Recoverin</a></li> <li><a href="/wiki/VSNL1" class="mw-redirect" title="VSNL1">Visinin</a></li></ul></li> <li><a href="/wiki/Parvalbumin" title="Parvalbumin">Parvalbumin</a></li> <li><a href="/wiki/Phospholamban" title="Phospholamban">Phospholamban</a></li> <li><a href="/wiki/Sarcalumenin" title="Sarcalumenin">Sarcalumenin</a></li> <li><a href="/wiki/Synaptotagmin" title="Synaptotagmin">Synaptotagmins</a> <ul><li><a href="/wiki/SYT1" title="SYT1">SYT1</a></li> <li><a href="/wiki/SYT2" title="SYT2">SYT2</a></li> <li><a href="/wiki/SYT3" title="SYT3">SYT3</a></li> <li><a href="/wiki/SYT4" title="SYT4">SYT4</a></li> <li><a href="/wiki/SYT5" title="SYT5">SYT5</a></li> <li><a href="/wiki/SYT6" title="SYT6">SYT6</a></li> <li><a href="/wiki/SYT7" title="SYT7">SYT7</a></li> <li><a href="/wiki/SYT9" title="SYT9">SYT9</a></li> <li><a href="/wiki/SYT11" title="SYT11">SYT11</a></li> <li><a href="/wiki/SYT13" title="SYT13">SYT13</a></li> <li><a href="/wiki/SYT14" class="mw-redirect" title="SYT14">SYT14</a></li></ul></li> <li><a href="/wiki/S100_protein" title="S100 protein">S100</a></li> <li><a href="/wiki/S100P" title="S100P">S100P</a></li> <li><a href="/wiki/Troponin_C" title="Troponin C">Troponin C</a> <ul><li><a href="/wiki/TNNC1" class="mw-redirect" title="TNNC1">TNNC1</a></li> <li><a href="/wiki/TNNC2" class="mw-redirect" title="TNNC2">TNNC2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-dependent <a href="/wiki/Chaperone_(protein)" title="Chaperone (protein)">chaperones</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calreticulin" title="Calreticulin">Calreticulin</a></li> <li><a href="/wiki/Calnexin" title="Calnexin">Calnexin</a></li> <li><a href="/wiki/HSPA5" class="mw-redirect" title="HSPA5">HSPA5</a></li> <li><a href="/wiki/HSP90B1" title="HSP90B1">HSP90B1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-dependent <a href="/wiki/Kinase" title="Kinase">kinases</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calmodulin-dependent_kinase" class="mw-redirect" title="Calmodulin-dependent kinase">CaM kinases</a> <ul><li><a href="/wiki/CAMK1" title="CAMK1">CAMK1</a></li> <li><a href="/wiki/CAMKII" class="mw-redirect" title="CAMKII">CAMK2</a> <ul><li><a href="/wiki/CAMK2A" class="mw-redirect" title="CAMK2A">A</a></li> <li><a href="/wiki/CAMK2B" title="CAMK2B">B</a></li> <li><a href="/wiki/CAMK2D" title="CAMK2D">D</a></li> <li><a href="/wiki/CAMK2G" title="CAMK2G">G</a></li></ul></li> <li><a href="/wiki/EEF2K" title="EEF2K">CAMK3</a></li> <li><a href="/wiki/CAMK4" title="CAMK4">CAMK4</a></li></ul></li> <li><a href="/wiki/Protein_kinase_C" title="Protein kinase C">Protein kinase C</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-dependent <a href="/wiki/Protease" title="Protease">proteases</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calpain" title="Calpain">Calpains</a> <ul><li><a href="/wiki/CAPN1" class="mw-redirect" title="CAPN1">CAPN1</a></li> <li><a href="/wiki/CAPN2" class="mw-redirect" title="CAPN2">CAPN2</a></li> <li><a href="/wiki/CAPN3" class="mw-redirect" title="CAPN3">CAPN3</a></li> <li><a href="/wiki/CAPNS1" class="mw-redirect" title="CAPNS1">CAPN4</a></li> <li><a href="/wiki/CAPN5" title="CAPN5">CAPN5</a></li> <li><a href="/wiki/CAPN6" class="mw-redirect" title="CAPN6">CAPN6</a></li> <li><a href="/w/index.php?title=CAPN7&action=edit&redlink=1" class="new" title="CAPN7 (page does not exist)">CAPN7</a></li> <li><a href="/wiki/CAPN8" class="mw-redirect" title="CAPN8">CAPN8</a></li> <li><a href="/wiki/CAPN9" class="mw-redirect" title="CAPN9">CAPN9</a></li> <li><a href="/wiki/CAPN10" title="CAPN10">CAPN10</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Indirect regulators</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcitonin" title="Calcitonin">Calcitonin</a></li> <li><a href="/wiki/Parathyroid_hormone" title="Parathyroid hormone">Parathyroid hormone</a></li> <li><a href="/wiki/Vitamin_D" title="Vitamin D">Vitamin D</a></li> <li><a href="/wiki/Vitamin_K" title="Vitamin K">Vitamin K</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Extracellular <a href="/wiki/Chelation" title="Chelation">chelators</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Extracellular_matrix" title="Extracellular matrix">Extracellular matrix</a> proteins</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibulin" title="Fibulin">Fibulins</a> <ul><li><a href="/wiki/FBLN1" title="FBLN1">FBLN1</a></li> <li><a href="/wiki/FBLN2" title="FBLN2">FBLN2</a></li> <li><a href="/wiki/FBLN3" class="mw-redirect" title="FBLN3">FBLN3</a></li> <li><a href="/wiki/FBLN4" class="mw-redirect" title="FBLN4">FBLN4</a></li> <li><a href="/wiki/FBLN5" title="FBLN5">FBLN5</a></li></ul></li> <li><a href="/wiki/Hemicentin_1" title="Hemicentin 1">Hemicentin 1</a></li> <li><a href="/wiki/Matrix_gla_protein" class="mw-redirect" title="Matrix gla protein">Matrix gla protein</a></li> <li><a href="/wiki/Osteonectin" title="Osteonectin">Osteonectin</a></li> <li><a href="/wiki/SIBLING_proteins" title="SIBLING proteins">SIBLINGs</a> <ul><li><a href="/wiki/Bone_sialoprotein" title="Bone sialoprotein">Bone sialoprotein</a></li> <li><a href="/wiki/DMP1" title="DMP1">Dentin matrix phosphoprotein</a></li> <li><a href="/wiki/Dentin_sialophosphoprotein" title="Dentin sialophosphoprotein">Dentin sialophosphoprotein</a></li> <li><a href="/wiki/Osteopontin" title="Osteopontin">Osteopontin</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hormone" title="Hormone">Secreted hormones</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Osteocalcin" title="Osteocalcin">Osteocalcin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-binding <a href="/wiki/Protein_domain" title="Protein domain">domains</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C2_domain" title="C2 domain">C2 domain</a></li> <li><a href="/wiki/Cadherin" title="Cadherin">Cadherin</a></li> <li><a href="/wiki/C-type_lectin" title="C-type lectin">C-type lectin</a></li> <li><a href="/wiki/EF_hand" title="EF hand">EF hand</a></li> <li><a href="/wiki/EGF-like_domain" title="EGF-like domain">EGF-like domain</a></li> <li><a href="/wiki/Gla_domain" title="Gla domain">Gla domain</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" 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