TY - JFULL AU - D. S. Mohale and A. V. Chandewar PY - 2013/1/ TI - Impact of Altered Behavioral Condition on Markers of Oxidative Stress and Different Biochemical Parameters T2 - International Journal of Pharmacological and Pharmaceutical Sciences SP - 991 EP - 996 VL - 7 SN - 1307-6892 UR - https://publications.waset.org/pdf/9997274 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 84, 2013 N2 - Aim- Study was undertaken to investigate the effect of altered behavioral condition like depression on various oxidative stress markers and biochemical parameters in rats. Methods- Rats were subjected for short (21 days) and long term (84 days) social isolation; the rats displayed an increase in depression on force swim test relative to control. Various markers of oxidative stress like lipid per oxidation (LPO), reduced glutathione (GSH), Supers oxide dismutase (SOD), catalase (CAT) and biochemical parameters like SGOT, SGPT, and blood glucose were determined. Results- There was significant increase in the level of LPO and decrease in the levels of GSH, SOD and CAT after long term isolation. Biochemical parameters were significantly altered after social isolation. Conclusion- Increased oxidative stress in depression which may leads to alteration of biochemical parameters. ER -