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Mass General Hospital researcher Gary Ruvkun honored with 2024 Nobel Prize
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<span>Medical Education</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> For trainees </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/prospective" target="_self"> <span>Prospective trainees</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/incoming" target="_self"> <span>Incoming trainees</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/current" target="_self"> <span>Current trainees</span> </a> </li> </ul> </li> </ul> </div> </li> <li> <a class="cmp-global-header-main-nav-item no-children mainNavigation-inactive internal" 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data-cmp-data-layer="{"float-image-teaser-89160eec36":{"@type":"aem-mgb/components/float-image-teaser","repo:modifyDate":"2024-10-08T13:42:02Z","dc:description":"<h2>Physiology or Medicine Prize award honors discovery of small regulatory RNAs</h2>\r\n<p><b>BOSTON</b>&nbsp;– Massachusetts General Hospital (MGH) and Harvard Medical School investigator&nbsp;<a href=\"https://molbio.massgeneral.org/labs/ruvkun-lab/\">Gary Ruvkun, PhD</a>, has been named a recipient of the 2024 Nobel Prize in Physiology or Medicine for his role in the discovery of microRNA and its role in post-transcriptional gene regulation. He shares the award with his collaborator&nbsp;<a href=\"https://www.umassmed.edu/ambroslab/\">Victor Ambros, PhD</a>, of the University of Massachusetts Medical School.</p>\r\n"}}"> <div class="cmp-teaser__content"> <figure class="cmp-float-image-teaser__image cmp-float-image-teaser__right cmp-float-image-teaser__twentyfive-percent"> <div> <div data-cmp-is="image" data-cmp-src="/content/mgb-global/global/en/about/newsroom/press-releases/mgh-researcher-gary-ruvkun-honored-with-2024-nobel-prize/_jcr_content/root/container_1214295969/float_image_teaser.coreimg{.width}.jpeg/1728394922238/gary-ruvkun-1070x700.jpeg" data-asset-id="7700f0d2-ae0c-4978-bf68-fb1ec7d4d01f" data-cmp-filereference="/content/dam/mgb-global/en/about/newsroom/press-releases/images/gary-ruvkun-1070x700.jpg" id="float-image-teaser-89160eec36-image" data-cmp-data-layer="{"float-image-teaser-89160eec36-image":{"@type":"aem-mgb/components/image","repo:modifyDate":"2024-10-08T13:42:02Z","xdm:linkURL":"/en/about/newsroom/press-releases/mgh-researcher-gary-ruvkun-honored-with-2024-nobel-prize","image":{"repo:id":"7700f0d2-ae0c-4978-bf68-fb1ec7d4d01f","repo:modifyDate":"2024-10-07T10:22:39Z","@type":"image/jpeg","repo:path":"/content/dam/mgb-global/en/about/newsroom/press-releases/images/gary-ruvkun-1070x700.jpg","xdm:smartTags":{"beard":0.784,"person":1.0,"headshot":0.895,"facial hair":0.795,"patient":0.774,"commercial photography":0.917,"buzz cut":0.78,"client":0.84,"bangs":0.83,"facing":0.761,"man":1.0,"moustache":0.895}}}}" data-cmp-hook-image="imageV3" class="cmp-image" itemscope itemtype="http://schema.org/ImageObject"> <a class="cmp-image__link" data-cmp-clickable href="/en/about/newsroom/press-releases/mgh-researcher-gary-ruvkun-honored-with-2024-nobel-prize"> <img src="/content/mgb-global/global/en/about/newsroom/press-releases/mgh-researcher-gary-ruvkun-honored-with-2024-nobel-prize/_jcr_content/root/container_1214295969/float_image_teaser.coreimg.jpeg/1728394922238/gary-ruvkun-1070x700.jpeg" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="1070" height="700" alt="Gary Ruvkun in lab"/> </a> </div> </div> <figcaption class="cmp-float-image-teaser__caption"> Gary Ruvkun, PhD</figcaption> </figure> <div class="cmp-teaser__description"><h2>Physiology or Medicine Prize award honors discovery of small regulatory RNAs</h2> <p><b>BOSTON</b> – Massachusetts General Hospital (MGH) and Harvard Medical School investigator <a href="https://molbio.massgeneral.org/labs/ruvkun-lab/">Gary Ruvkun, PhD</a>, has been named a recipient of the 2024 Nobel Prize in Physiology or Medicine for his role in the discovery of microRNA and its role in post-transcriptional gene regulation. He shares the award with his collaborator <a href="https://www.umassmed.edu/ambroslab/">Victor Ambros, PhD</a>, of the University of Massachusetts Medical School.</p> </div> </div> </div> </div> <div class="global-button button cmp-button-global-blue-white aem-GridColumn aem-GridColumn--default--12"> <a id="button-556f881600" class="cmp-button-external" href="https://www.youtube.com/watch?v=WSg9u44DmSk" target="_blank" data-cmp-clickable data-cmp-data-layer="{"button-556f881600":{"@type":"core/wcm/components/button/v2/button","repo:modifyDate":"2024-10-08T13:41:03Z","dc:title":"Watch Gary Ruvkun's Nobel Prize press conference","xdm:linkURL":"https://www.youtube.com/watch?v=WSg9u44DmSk"}}"> <span class="cmp-button-text">Watch Gary Ruvkun's Nobel Prize press conference</span> <!-- Not Phone/Download Icon --> <!-- External Link Icon --> <span class="sr-only">(opens external link in new tab)</span> <svg aria-hidden="true" class="cmp-button-icon" viewBox="0 0 32 32" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" fill="currentColor" d="M17.158 6.312c0 .725.587 1.313 1.312 1.313h4.069l-7.402 7.401a1.225 1.225 0 0 0 0 1.733l.104.104a1.225 1.225 0 0 0 1.733 0l7.402-7.401v4.069a1.312 1.312 0 0 0 2.624 0V6.312C27 5.587 26.413 5 25.688 5H18.47c-.725 0-1.312.588-1.312 1.312m6.45 18.243H8.392a.947.947 0 0 1-.947-.947V8.392c0-.523.424-.947.947-.947h5.648c.577 0 1.044-.468 1.044-1.045v-.355c0-.577-.467-1.045-1.044-1.045H7.862A2.87 2.87 0 0 0 5 7.862v16.275A2.871 2.871 0 0 0 7.863 27h16.274A2.87 2.87 0 0 0 27 24.137v-6.176c0-.577-.468-1.044-1.044-1.044H25.6c-.576 0-1.044.467-1.044 1.044v5.647a.947.947 0 0 1-.947.947"/> </svg> </a> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div data-cmp-data-layer="{"text-eab7169f39":{"@type":"aem-mgb/components/text","repo:modifyDate":"2024-10-08T13:42:02Z","xdm:text":"<p>Instead of being translated into proteins, as messenger RNAs are, the hundred-times-smaller microRNAs block gene expression by binding to regulatory segments in their target messenger RNAs. Current knowledge suggests that most plant and animal genomes, including the human genome, contain more than 1,000 microRNAs, which control many protein-coding messenger RNAs and may be involved in a broad range of normal- and disease-related activities.<br>\r\n</p>\r\n<p>Human microRNAs have been implicated in heart disease, in viral pathogenesis and in regulation of neural function and disease. Human therapies based on microRNAs are in clinical trials for heart disease, cancer, neurodegenerative diseases, and more.</p>\r\n<p>The pair began investigating genes that control development in the C. elegans roundworm. As fellows at Massachusetts Institute of Technology, they worked together to isolate a gene called lin-14 that operates in concert with a gene called lin-4 to regulate the transition through key developmental stages.</p>\r\n<p>After establishing his own laboratory in the <a href=\"https://molbio.massgeneral.org/\" target=\"_blank\">MGH Department of Molecular Biology</a>, Ruvkun continued collaborating with Ambros – then at Harvard – to uncover how the two regulatory genes interacted. They discovered that lin-4 did not block the activity of lin-14 through the protein for which it coded, but in a manner never seen before by direct interaction between the two genes’ RNA strands. The lin-4 RNA was also much smaller than any other RNA that previously had been studied, 22 nucleotides long.</p>\r\n<p>In 2000, Ruvkun’s team discovered the second microRNA, let-7, that shuts down its target mRNA by base pairing to it in the same way that lin-4 silences lin-14. The Ruvkun lab also discovered that diverse animals, ranging from flies to fish to humans, have a let-7 microRNA that exactly matches the C. elegans let-7 microRNA, implying that this mechanism of translational regulation was present in the common ancestor to all animals and has been maintained by natural selection since these species diverged almost a billion years ago.</p>\r\n<p>These findings established that microRNAs are universal to animals and not unique to C. elegans. Over the past two decades, research into the potential of microRNAs for the diagnosis, prognosis and treatment of disease has expanded from the two original papers published by Ruvkun and Ambros in 1993 to 176,000 papers today.</p>\r\n<p>In addition to continuing investigation of microRNA’s role in controlling gene expression, Ruvkun’s team studies other mechanisms involved in the development, metabolism and longevity of C. elegans, including genes involved in the regulation and storage of fat.</p>\r\n<p>In 2016, his team identified molecules essential to the ability of C. elegans cells to recognize dysfunction of the proteasome, a cellular component that degrades unneeded or defective proteins, findings that may be applicable to important human neurodegenerative diseases.</p>\r\n<p>It is significant, Ruvkun notes, that unlike the majority of U.S. university and hospital research units, the MGH Department of Molecular Biology fully supported his research expenses during the decade when this research was initiated.</p>\r\n<p>Over the next decade, MGH-supplied research funds supported half of Ruvkun’s research budget. Much of the departmental research support was the result of a unique funding relationship between MGH and the German chemical company Hoechst AG. Ruvkun wishes to acknowledge how much this unique research support by his home institution empowered his research program.</p>\r\n<p>Ruvkun is a professor of Genetics at Harvard Medical School, an investigator at the MGH Department of Molecular Biology and a member of the MGH Research Institute. He holds a bachelor’s degree in Biophysics from the University of California at Berkeley and a PhD in Biophysics from Harvard University.</p>\r\n<p>In 2008 Ruvkun, Ambros and David Baulcombe of the University of Cambridge received the <a href=\"https://laskerfoundation.org/winners/tiny-rnas-that-regulate-gene-function/\" target=\"_blank\">Lasker Award for Basic Medical Research</a> for the work currently being honored. Among the many other awards Ruvkun has received – some shared with Ambros and Baulcombe – are the Franklin Medal, the Gairdner International Award, the 2012 Paul Janssen Award for Biomedical Research, the 2014 Gruber Genetics Prize, the 2015 Breakthrough Prize in Life Sciences, the 2016 March of Dimes Prize and the 2008 Warren Triennial Prize from MGH.</p>\r\n<p>A member of the National Academy of Sciences, Ruvkun has co-led a NASA-funded Search for Extraterrestrial genomes, which has proposed using DNA sequencing techniques, commonly used to detect and classify organisms here on Earth, as part of the search for life on Mars or other planets.</p>\r\n"}}" id="text-eab7169f39" class="cmp-text"> <p>Instead of being translated into proteins, as messenger RNAs are, the hundred-times-smaller microRNAs block gene expression by binding to regulatory segments in their target messenger RNAs. Current knowledge suggests that most plant and animal genomes, including the human genome, contain more than 1,000 microRNAs, which control many protein-coding messenger RNAs and may be involved in a broad range of normal- and disease-related activities.<br> </p> <p>Human microRNAs have been implicated in heart disease, in viral pathogenesis and in regulation of neural function and disease. Human therapies based on microRNAs are in clinical trials for heart disease, cancer, neurodegenerative diseases, and more.</p> <p>The pair began investigating genes that control development in the C. elegans roundworm. As fellows at Massachusetts Institute of Technology, they worked together to isolate a gene called lin-14 that operates in concert with a gene called lin-4 to regulate the transition through key developmental stages.</p> <p>After establishing his own laboratory in the <a href="https://molbio.massgeneral.org/" target="_blank">MGH Department of Molecular Biology</a>, Ruvkun continued collaborating with Ambros – then at Harvard – to uncover how the two regulatory genes interacted. They discovered that lin-4 did not block the activity of lin-14 through the protein for which it coded, but in a manner never seen before by direct interaction between the two genes’ RNA strands. The lin-4 RNA was also much smaller than any other RNA that previously had been studied, 22 nucleotides long.</p> <p>In 2000, Ruvkun’s team discovered the second microRNA, let-7, that shuts down its target mRNA by base pairing to it in the same way that lin-4 silences lin-14. The Ruvkun lab also discovered that diverse animals, ranging from flies to fish to humans, have a let-7 microRNA that exactly matches the C. elegans let-7 microRNA, implying that this mechanism of translational regulation was present in the common ancestor to all animals and has been maintained by natural selection since these species diverged almost a billion years ago.</p> <p>These findings established that microRNAs are universal to animals and not unique to C. elegans. Over the past two decades, research into the potential of microRNAs for the diagnosis, prognosis and treatment of disease has expanded from the two original papers published by Ruvkun and Ambros in 1993 to 176,000 papers today.</p> <p>In addition to continuing investigation of microRNA’s role in controlling gene expression, Ruvkun’s team studies other mechanisms involved in the development, metabolism and longevity of C. elegans, including genes involved in the regulation and storage of fat.</p> <p>In 2016, his team identified molecules essential to the ability of C. elegans cells to recognize dysfunction of the proteasome, a cellular component that degrades unneeded or defective proteins, findings that may be applicable to important human neurodegenerative diseases.</p> <p>It is significant, Ruvkun notes, that unlike the majority of U.S. university and hospital research units, the MGH Department of Molecular Biology fully supported his research expenses during the decade when this research was initiated.</p> <p>Over the next decade, MGH-supplied research funds supported half of Ruvkun’s research budget. Much of the departmental research support was the result of a unique funding relationship between MGH and the German chemical company Hoechst AG. Ruvkun wishes to acknowledge how much this unique research support by his home institution empowered his research program.</p> <p>Ruvkun is a professor of Genetics at Harvard Medical School, an investigator at the MGH Department of Molecular Biology and a member of the MGH Research Institute. He holds a bachelor’s degree in Biophysics from the University of California at Berkeley and a PhD in Biophysics from Harvard University.</p> <p>In 2008 Ruvkun, Ambros and David Baulcombe of the University of Cambridge received the <a href="https://laskerfoundation.org/winners/tiny-rnas-that-regulate-gene-function/" target="_blank">Lasker Award for Basic Medical Research</a> for the work currently being honored. Among the many other awards Ruvkun has received – some shared with Ambros and Baulcombe – are the Franklin Medal, the Gairdner International Award, the 2012 Paul Janssen Award for Biomedical Research, the 2014 Gruber Genetics Prize, the 2015 Breakthrough Prize in Life Sciences, the 2016 March of Dimes Prize and the 2008 Warren Triennial Prize from MGH.</p> <p>A member of the National Academy of Sciences, Ruvkun has co-led a NASA-funded Search for Extraterrestrial genomes, which has proposed using DNA sequencing techniques, commonly used to detect and classify organisms here on Earth, as part of the search for life on Mars or other planets.</p> </div> </div> <div class="experiencefragment aem-GridColumn aem-GridColumn--default--12"> <div id="experiencefragment-0ea4df7580" class="cmp-experiencefragment cmp-experiencefragment--media-contact"> <div id="container-63f5a11ad0" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="contact-block cmp-contact-block-contact cmp-contact-block-contact-standard aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-contact-block-contact-container"> <div class="cmp-contact-block-details-container"> <div class="cmp-contact-block-details"> <h2 class="cmp-contact-block-title">Media contact</h2> <div class="cmp-contact-block-title-divider"></div> <div class="cmp-contact-block-details-info-container no-image"> <div class="cmp-contact-block-name"> <span class="cmp-contact-block-name-field">Mike Morrison</span> </div> <div class="cmp-contact-block-job-title">Senior Director, External Communications, Hospitals</div> <div class="cmp-contact-block-email-phone"> <a class="cmp-contact-block-email-link" href="mailto: mdmorrison@mgb.org">mdmorrison@mgb.org</a> </div> </div> </div> <div class="cmp-contact-block-call-button"> <div class="global-button button cmp-injectedComponent"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div data-cmp-data-layer="{"text-266881a8e8":{"@type":"aem-mgb/components/text","repo:modifyDate":"2024-10-08T13:42:02Z","xdm:text":"<h3>About Massachusetts General Hospital<br>\r\n</h3>\r\n<p>Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. 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For more information about these cookies and the data collected, please refer to our <a target="_blank" href='/en/notices/web-privacy-policy' class="privacy_policy" aria-label='Privacy Policy'><span>Privacy Policy</span></a>. </p> </td> <td style="min-width: 1rem;"> <a href='#cookieNoticeClose' aria-label='Cookie Notice Close' id='cookieNoticeClose'><span class="close">×</span></a> </td> </tr> </table> </div> </div> </div> <script type="text/javascript"> var modal = document.getElementById('footerModal'); var closeBtn = document.querySelector('.footer__notice .modal-body #cookieNoticeClose'); //var okBtn = document.querySelector('.footer__notice .modal-body a'); var footerNotifyIndex = document.cookie.indexOf("privacynotifymgb"); closeBtn.focus(); closeBtn.onclick = function(event) { event.preventDefault(); modal.style.display = "none"; var now = new Date(); now.setTime(now.getTime() + 365 * 24 * 3600 * 1000);//One year document.cookie = "privacynotifymgb=; expires=" + now.toUTCString() + "; path=/"; } if(footerNotifyIndex === -1){ modal.style.display = "block"; } document.addEventListener('keyup', function (e) { if(e.target.hash){ var id = e.target.hash.replace(/[?#]/gi, ''); var spanBtn = document.querySelector('.footer__notice .modal-body .close'); if(id && id == 'cookieNoticeClose' && e.code == 'Tab'){ spanBtn.style.border = "1px solid #01b9e8"; } else{ var skipContent = document.getElementById('skipContent'); skipContent.focus(); spanBtn.style.border = "none"; } } }); </script> </div> </div> </div> </div> </div> </footer> </div> </div> </div> <script src="/etc.clientlibs/aem-mgb/clientlibs/clientlib-site.lc-09901b4a0a833ac7cb0c1adfb0ae67d0-lc.min.js"></script> <script src="/etc.clientlibs/clientlibs/granite/jquery/granite/csrf.lc-652a558c3774088b61b0530c184710d1-lc.min.js"></script> <script src="/etc.clientlibs/core/wcm/components/commons/site/clientlibs/container.lc-0a6aff292f5cc42142779cde92054524-lc.min.js"></script> <script src="/etc.clientlibs/aem-mgb/clientlibs/clientlib-base.lc-27ce2d211fdf41ad5837f5a0cbd77961-lc.min.js"></script> </body> </html>