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class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">1888</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (106)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (690)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Periodontitis/pathology</label> </div> <div 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class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Ming P</b>, Li B, Li Q, Yuan L, Jiang X, Liu Y, Cai R, Zhou P, Lan X, Tao G, Xiao J. Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122885. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39423514' target='_blank'>39423514</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122885' target='_blank'>10.1016/j.biomaterials.2024.122885</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122885','39423514', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122885' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.biomaterials.2024.122885" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is a chronic inflammation caused by dental plaque. It is characterized by the accumulation of excessive reactive oxygen species (ROS) and inflammatory mediators in the periodontal area. This affects the function of host cells, activates osteoclasts, and destroys periodontal tissue. Treatments such as local debridement or antibiotic therapy for ameliorating the overactive inflammatory microenvironment and repairing periodontal tissues are challenging. This paper reports multifunctional nanoplatforms (Se-CuSrHA@EGCG) based on sericin with ROS-scavenging, immunomodulatory, angiogenic, and osteogenic capabilities. The natural protein sericin, derived from silk cocoons, is used in water/oil emulsification and cross-linking processes to create sericin nanoparticles (Se NPs). Numerous binding sites are present on the surface of Se NPs. Ion-doped hydroxyapatite nanoparticles (Se-CuSrHA NPs) can be constructed using the force between positive and negative charges. After mineralization, an antioxidant coating is formed on the surface using polyethyleneimine (PEI)/epigallocatechin gallate (EGCG). Research conducted both in vitro and in vivo demonstrates that Se-CuSrHA@EGCG NPs can efficiently scavenge ROS, regulate macrophage polarization, increase the secretion of anti-inflammatory cytokines, and balance the immune microenvironment. In addition, Se-CuSrHA@EGCG stimulates angiogenesis, inhibits osteoclasts, and accelerates periodontal tissue repair. Therefore, this is a preferable strategy to accelerate bone regeneration in patients with periodontitis. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+mineralization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic mineralization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multifunctional+nanoplatforms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multifunctional nanoplatforms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+tissue+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal tissue regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS-scavenging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS-scavenging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sericin+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sericin nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sericins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sericins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sericins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sericins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunologic+Factors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunologic Factors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunologic+Factors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunologic Factors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunologic+Factors%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunologic Factors/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Physiologic%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Physiologic/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomineralization%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomineralization/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Lam W</b>, Yao Y, Tang C, Wang Y, Yuan Q, Peng L. Bifunctional mesoporous HMUiO-66-NH<sub>2</sub> nanoparticles for bone remodeling and ROS scavenging in periodontitis therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122872. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39383779' target='_blank'>39383779</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>10.1016/j.biomaterials.2024.122872</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122872','39383779', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.biomaterials.2024.122872" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontal bone defects represent an irreversible consequence of periodontitis associated with reactive oxygen species (ROS). However, indiscriminate removal of ROS proves to be counterproductive for tissue repair and insufficient for addressing existing bone defects. In the treatment of periodontitis, it is crucial to rationally alleviate local ROS while simultaneously promoting bone regeneration. In this study, Zr-based large-pore hierarchical mesoporous metal-organic framework (MOF) nanoparticles (NPs) HMUiO-66-NH2 were successfully proposed as bifunctional nanomaterials for bone regeneration and ROS scavenging in periodontitis therapy. HMUiO-66-NH2 NPs demonstrated outstanding biocompatibility both in vitro and in vivo. Significantly, these NPs enhanced the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) under normal and high ROS conditions, upregulating osteogenic gene expression and mitigating oxidative stress. Furthermore, in vivo imaging revealed a gradual degradation of HMUiO-66-NH2 NPs in periodontal tissues. Local injection of HMUiO-66-NH2 effectively reduced bone defects and ROS levels in periodontitis-induced C57BL/6 mice. RNA sequencing highlighted that differentially expressed genes (DEGs) are predominantly involved in bone tissue development, with notable upregulation in Wnt and TGF-β signaling pathways. In conclusion, HMUiO-66-NH2 exhibits dual functionality in alleviating oxidative stress and promoting bone repair, positioning it as an effective strategy against bone resorption in oxidative stress-related periodontitis. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bifunctional+nanomaterials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bifunctional nanomaterials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HMUiO-66-NH(2)+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HMUiO-66-NH(2) nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+scavenging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS scavenging</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Cai X</b>, Fan S, Sui B, Xuan Z, Huang X, Liu A, Chen J, Wang H, Liu J, Xu H, Zheng C, Guo H. Neutrophils suppress osteogenic differentiation of Gli1<sup>+</sup> stem cells via neutrophil extracellular traps and contribute to bone loss in periodontitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>737</b>:150916. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39489114' target='_blank'>39489114</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150916' target='_blank'>10.1016/j.bbrc.2024.150916</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150916','39489114', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150916' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.bbrc.2024.150916" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is a severe and chronic oral inflammatory disease that leads to the progressive and irreversible destruction of periodontal tissues, ultimately resulting in tooth loss. Among the immune cell subtypes involved, neutrophils play a crucial role in the initiation and progression of periodontitis. Mesenchymal stem cells (MSCs) are essential components of periodontal tissue, contributing to tissue development, homeostasis, and regeneration. Recent studies have demonstrated that neutrophils significantly affect the function of MSCs by changing the inflammatory environment. However, the specific effects of neutrophils on periodontal MSCs during periodontitis remain unclear, highlighting a gap in our understanding of the disease mechanisms. In this study, we utilized the Gli1-CreERT2;mT/mG transgenic mouse model to specifically mark Gli1+ cells, a critical and representative subset of MSCs in the periodontal tissues responsible for maintaining tissue homeostasis. We reveal that neutrophils inhibit the osteogenic differentiation of Gli1+ cells and exacerbate alveolar bone destruction by secreting neutrophil extracellular traps (NETs), which induce endoplasmic reticulum stress in Gli1+ cells. These findings highlight the pivotal impact of neutrophils on distinct subpopulations of periodontal MSCs in the pathogenesis of periodontitis, offering valuable insights into the underlying mechanisms of the disease and suggesting potential future therapeutic strategies aimed at modulating the interactions between neutrophils and MSCs. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gli1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gli1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophil+extracellular+traps%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophil extracellular traps</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zinc+Finger+Protein+GLI1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zinc Finger Protein GLI1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zinc+Finger+Protein+GLI1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zinc Finger Protein GLI1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Traps%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Traps/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+Reticulum+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic Reticulum Stress</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Luo W</b>, Sun L. O-Linked N-Acetylglucosamine Transferase Regulates Bone Homeostasis Through Alkaline Phosphatase Pathway in Diabetic Periodontitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(17004);'>Mol Biotechnol</em> 2024;<b>66</b>:3475-3484. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37951846' target='_blank'>37951846</a> DOI: <a href='https://dx.doi.org/10.1007/s12033-023-00947-0' target='_blank'>10.1007/s12033-023-00947-0</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12033-023-00947-0','37951846', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12033-023-00947-0' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17004);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/14/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1007/s12033-023-00947-0" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is one of the most common complications of diabetes, which seriously affects patients' life quality. It is important to find the key factors and mechanisms to improve the treatment of periodontitis. In our study, high glucose (HG) and lipopolysaccharide (LPS) treated human periodontal ligament cells (hPDLCs) and LPS treated diabetic mice was used to establish the diabetic periodontitis model in vitro and in vivo. O-linked beta-N-acetylglucosamine glycosylation (O-GlcNAcylation) and O-linked N-acetylglucosamine transferase (OGT) protein levels were detected by western blot assay. Cell counting kit-8, alkaline phosphatase (ALP), and alizarin red staining (ARS) assays were used to observe the O-GlcNAcylation and OGT effects on cell viability and osteoblast differentiation. Co-immunoprecipitation (Co-IP) assay was used to detect the relationship between OGT and ALP. The results showed that the levels of OGT and O-GlcNAcylation were significantly increased in both cell and mouse models. ALP and ARS staining results showed that silencing of OGT or inhibition of O-glycosylation notably improved osteogenic differentiation, increased the osteoprotegerin (OPG) protein levels and decreased the receptor activator for nuclear factor-κB Ligand (RANKL) protein levels of the HG and LPS treated hPDLCs. In diabetic periodontitis mice, knockdown of OGT relieved the injury of gingival tissue, increased the ALP and OPG levels and decreased the RANKL levels. Besides, ALP interacted with OGT protein, and OGT protein was found to act on ALP serine 513 glycosylation. In conclusion, our study demonstrated that excessive O-GlcNAcylation could restrain osteoblast differentiation by O-glycosylation in ALP. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22O-GlcNAcylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">O-GlcNAcylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-Acetylglucosaminyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-Acetylglucosaminyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-Acetylglucosaminyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-Acetylglucosaminyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Lin XJ</b>, Yuan Q, Zhou J, Dong YL, Sunchuri D, Guo ZL. Cellular senescence: A new perspective on the suppression of periodontitis (Review). <em class='incite-journal-name' onclick='ShowInCiteJournal(17029);'>Mol Med Rep</em> 2024;<b>30</b>:238. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39422030' target='_blank'>39422030</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529191' target='_blank'>PMC11529191</a> DOI: <a href='https://dx.doi.org/10.3892/mmr.2024.13362' target='_blank'>10.3892/mmr.2024.13362</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3892/mmr.2024.13362','39422030', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3892/mmr.2024.13362' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17029);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.3892/mmr.2024.13362" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cellular senescence, characterized by cell cycle arrest, can result in tissue dysfunction when senescent cells persist and accumulate. Periodontitis, a chronic inflammatory condition caused by the interaction between bacteria and the immune system of the host, primarily manifests as damage to periodontal tissues. Aging and inflammation are interlinked processes that exacerbate each other. The progression of localized chronic periodontal inflammation is often accelerated in conjunction with tissue and organ aging. The presence of senescent cells and release of inflammatory cytokines, immune modulators, growth factors and proteases that are associated with the senescence‑associated secretory phenotype contribute to the deterioration of periodontal tissues. The present review aimed to elucidate the mechanisms of cellular senescence and its potential impact on periodontitis, offering novel insights for modulating the inflammatory microenvironment of periodontal tissues. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cellular+senescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cellular senescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22senescence-associated+secretory+phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">senescence-associated secretory phenotype</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Senescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Senescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Chen P</b>, Lin X, Zhang C, Xie Y, Guo Z, Ren F. Fusobacterium nucleatum-infected periodontitis promotes renal interstitial fibrosis in rats through the TGF-β/SMAD2/3 and β-catenin signaling pathways. <em class='incite-journal-name' onclick='ShowInCiteJournal(9624);'>Gene</em> 2024;<b>927</b>:148729. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38936784' target='_blank'>38936784</a> DOI: <a href='https://dx.doi.org/10.1016/j.gene.2024.148729' target='_blank'>10.1016/j.gene.2024.148729</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.gene.2024.148729','38936784', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.gene.2024.148729' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9624);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.gene.2024.148729" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVES</div><div class="abstract-content">Periodontitis is associated with Fusobacterium nucleatum (F.n) infection. Although the colonization of renal tissue by F.n is well documented, its specific role in kidney disease has yet to be determined. This study aimed to investigate the potential association between F.n-induced periodontitis and renal interstitial fibrosis. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The rat gingival sulcus was injected with F.n suspension, while the control group (NC) was injected with PBS. The levels of total protein (TP), albumin (ALB), creatinine, and urea nitrogen (BUN) in rat serum and/or urine were quantified using the appropriate kits. Renal interstitial fibrosis and epithelial-mesenchymal transition (EMT) were evaluated in rats using Masson staining, Periodic Schiff-Methenamine (PASM) staining, and immunohistochemical staining. The levels of fibrosis- and EMT-related proteins and the TGF-β/SMAD2/3 and β-catenin signaling pathways were determined using Western blot analysis. F.n in the kidney tissues was quantitatively determined using bacterial 16S rRNA technology. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Serum levels of TP, ALB, creatinine, and BUN were not significantly decreased in F.n-infected rats with periodontitis. The levels of creatinine and ALB in the urine were not statistically different between two groups. Masson and PASM staining showed that F.n-induced periodontitis could promote renal interstitial fibrosis in rats. The levels of collagen I, fibronectin (FN), vimentin, and α-SMA were upregulated in the kidney tissues of rats with F.n-induced periodontitis and in F.n-treated HK-2 cells. However, E-cadherin levels were reduced. F.n promoted renal interstitial and HK-2 cell fibrosis in rats by modulating the TGF-β/SMAD2/3 and β-catenin signaling pathways. F.n colonization increased renal interstitial fibrosis in rats. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">F.n-induced periodontitis promoted EMT by activating the TGF-β/SMAD2/3 and β-catenin signaling pathways, thus promoting renal interstitial fibrosis in rats. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-mesenchymal+transition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-mesenchymal transition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fusobacterium+nucleatum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fusobacterium nucleatum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+interstitial+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal interstitial fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TGF-%ce%b2%2fSMAD2%2f3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TGF-β/SMAD2/3</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fusobacterium+nucleatum%2fpathogenicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fusobacterium nucleatum/pathogenicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22beta+Catenin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">beta Catenin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/microbiology</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fusobacterium+Infections%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fusobacterium Infections/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fusobacterium+Infections%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fusobacterium Infections/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Ye JR</b>, Park SH, Kang SW, Kwack KH, Chae YK, Lee HS, Choi SC, Nam OH. Effect of oxyresveratrol under in vitro lipopolysaccharide-induced periodontitis environment. <em class='incite-journal-name' onclick='ShowInCiteJournal(4087);'>BMC Oral Health</em> 2024;<b>24</b>:1382. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39548434' target='_blank'>39548434</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566898' target='_blank'>PMC11566898</a> DOI: <a href='https://dx.doi.org/10.1186/s12903-024-05128-2' target='_blank'>10.1186/s12903-024-05128-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12903-024-05128-2','39548434', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12903-024-05128-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4087);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1186/s12903-024-05128-2" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Oxyresveratrol is the main constituent of mulberries and has many bioactive properties beneficial to human health. The purpose of this study was to assess the anti-inflammatory effects of oxyresveratrol on in vitro periodontitis model. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Human periodontal ligament cells were treated with oxyresveratrol (0, 10, and 20 µg/mL) for 72 h. Cell viability and flow cytometry assays were performed. To investigate anti-inflammatory effect of oxyresveratrol on periodontal inflammation, nitric oxide production under lipopolysaccharide stimulation was assessed. Next, expression of biomarkers associated periodontal inflammation was evaluated. Scratch wound assay was performed to evaluate cell migration/proliferation potential of oxyresveratrol under lipopolysaccharide stimulation. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Periodontal ligament cell toxicity was not observed in oxyresveratrol treatment. Oxyresveratrol treatment significantly inhibited nitric oxide production and reduced MMP-2, MMP-9, TNF-α, IL-6, and IL-8 expressions after lipopolysaccharide stimulation. Regarding cell migration/proliferation, open wound area in oxyresveratrol (33.28 ± 6.80%) was the lowest (p < 0.05). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Within the limits of this study, oxyresveratrol inhibited lipopolysaccharide-induced inflammation in periodontal ligament cells and promoted periodontal ligament cell migration/proliferation. These findings suggest that oxyresveratrol could be valuable for the management of periodontal diseases. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+product%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural product</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+ligament+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal ligament cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/pharmacology</a></li><li><a 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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1. <em class='incite-journal-name' onclick='ShowInCiteJournal(4417);'>Cancer Immunol Immunother</em> 2024;<b>74</b>:22. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39535607' target='_blank'>39535607</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561227' target='_blank'>PMC11561227</a> DOI: <a href='https://dx.doi.org/10.1007/s00262-024-03865-5' target='_blank'>10.1007/s00262-024-03865-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00262-024-03865-5','39535607', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00262-024-03865-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4417);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1007/s00262-024-03865-5" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Our study investigated the role of experimental periodontitis on tumor growth, local and systemic immunosuppressive status, and programmed death receptor 1 (PD-1) / programmed death ligand 1 (PD-L1) expression in oral squamous cell carcinoma (OSCC) and prostate cancer. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Mouse oral or prostate cancer xenograft models were divided into control, periodontitis and periodontitis + anti-PD-1 groups. Tumor volume and weight were recorded and the levels of relevant immune-suppressive cells and T cells were detected by flow cytometry or immunofluorescence. THP-1 cells were stimulated using conditioned media of LPS-stimulated Cal-27 cells and PD-L1 expression was measured by quantitative real-time PCR, western blotting and immunofluorescence. Tumor specimens from OSCC patients with or without periodontitis were also collected for immunofluorescence. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Periodontitis significantly promoted tumor volume and weight. Compared to the control, the proportions of tumor-associated macrophages (TAMs), regulatory T cells (Tregs), PD-L1+TAMs and PD-1+CD8+T cells increased, while CD8+T cells decreased in the periodontitis group. Immunofluorescence demonstrated that there was an increase in PD-L1+TAMs and PD-1+CD8+T cells, but a decrease in IFN-γ+CD8+T cells in both xenografts and clinical OSCC samples with periodontitis. In vitro, LPS-stimulated Cal-27 cells had a stronger potential to induce PD-L1 expression in macrophages compared with unstimulated Cal-27 cells. And the promoting effect of periodontitis on tumor growth and immune evasion was significantly attenuated after anti-PD-1 therapy. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Periodontitis may facilitate tumor growth and immune escape evidenced by the increased immune-suppressive cells and the decreased functional T cells, via enhancing PD-1/PD-L1 expression in the tumor microenvironment. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer</a></li><li><a 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Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(21544);'>Stem Cell Res Ther</em> 2024;<b>15</b>:393. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39491017' target='_blank'>39491017</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533400' target='_blank'>PMC11533400</a> DOI: <a href='https://dx.doi.org/10.1186/s13287-024-03998-5' target='_blank'>10.1186/s13287-024-03998-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13287-024-03998-5','39491017', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13287-024-03998-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21544);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1186/s13287-024-03998-5" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and is characterized by the destruction of periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration of the periodontal tissue. Mesenchymal stem cells (MSCs) represent a promising approach to periodontal tissue regeneration. Recently, the prominent role of MSCs in this context has been attributed to microRNAs (miRNAs), which participate in post-transcriptional regulation and are crucial for various physiological and pathological processes. Additionally, they function as indispensable elements in extracellular vesicles, which protect them from degradation. In periodontitis, MSCs-derived miRNAs play a pivotal role in cellular proliferation and differentiation, angiogenesis of periodontal tissues, regulating autophagy, providing anti-apoptotic effects, and mediating the inflammatory microenvironment. As a cell-free strategy, their small size and ability to target related sets of genes and regulate signaling networks predispose miRNAs to become ideal candidates for periodontal tissue regeneration. This review aims to introduce and summarize the potential functions and mechanisms of MSCs-derived miRNAs in periodontal tissue repair and regeneration. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+tissue+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal tissue regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U21A20369 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Key+Technologies+Research+and+Development+Program%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SQ2021YFA1100600 Key Technologies Research and Development Program</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>He Z</b>, Lv JC, Zheng ZL, Gao CT, Xing JW, Li BL, Liu HH, Liu Y, Xu JZ, Li ZM, Luo E. Hierarchically structured nanofibrous scaffolds spatiotemporally mediate the osteoimmune micro-environment and promote osteogenesis for periodontitis-related alveolar bone regeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(337);'>Acta Biomater</em> 2024;<b>189</b>:323-336. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39395703' target='_blank'>39395703</a> DOI: <a href='https://dx.doi.org/10.1016/j.actbio.2024.10.008' target='_blank'>10.1016/j.actbio.2024.10.008</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.actbio.2024.10.008','39395703', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.actbio.2024.10.008' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(337);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.actbio.2024.10.008" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis suffer from inflammation-induced destruction of periodontal tissues, resulting in the serious loss of alveolar bone. Controlling inflammation and promoting bone regeneration are two crucial aspects for periodontitis-related alveolar bone defect treatment. Herein, we developed a hierarchically structured nanofibrous scaffold with a nano-embossed sheath and a bone morphogenetic protein 2-loaded core to match the periodontitis-specific features that spatiotemporally modulated the osteoimmune environment and promoted periodontal bone regeneration. We investigated the potential of this unique scaffold to treat periodontitis-related alveolar bone defects in vivo and in vitro. The results demonstrated that the hierarchically structured scaffold effectively reduced the inflammatory levels in macrophages and enhanced the osteogenic potential of bone mesenchymal stem cells in an inflammatory microenvironment. Moreover, in vivo experiments revealed that the hierarchically structured scaffold significantly ameliorated inflammation in the periodontium and inhibited alveolar bone resorption. Notably, the hierarchically structured scaffold also exhibited a prolonged effect on promoting alveolar bone regeneration. These findings highlight the significant therapeutic potential of hierarchically structured nanofibrous scaffolds for the treatment of periodontitis, and their promising role in the field of periodontal tissue regeneration. STATEMENT OF SIGNIFICANCE: We present a novel hierarchically structured nanofibrous scaffold of coupling topological and biomolecular signals for precise spatiotemporal modulation of the osteoimmune micro-environment. Specifically, the scaffold was engineered via coaxial electrospinning of the poly(ε-caprolactone) sheath and a BMP-2/polyvinyl alcohol core, followed by surface-directed epitaxial crystallization to generate cyclic nano-lamellar embossment on the sheath. With this unique hierarchical structure, the cyclic nano-lamellar sheath provided a direct nano-topographical cue to alleviate the osteoimmune environment, and the stepwise release of BMP-2 from the core provided a biological cue for bone regeneration. This research underscores the potential of hierarchically structured nanofibrous scaffolds as a promising therapeutic approach for periodontal tissue regeneration and highlights their role in advancing periodontal tissue engineering. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electrospun+scaffold%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electrospun scaffold</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoimmune%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoimmune</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Topographical+cues%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Topographical cues</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Scaffolds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Scaffolds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanofibers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanofibers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Morphogenetic+Protein+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Morphogenetic Protein 2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Microenvironment%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Microenvironment/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Ren J</b>, Li J, Tang H, Hao L, Yang K. TFEB alleviates periodontitis by activating autophagy and inhibiting inflammation. <em class='incite-journal-name' onclick='ShowInCiteJournal(22923);'>Transl Res</em> 2024;<b>273</b>:127-136. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39181195' target='_blank'>39181195</a> DOI: <a href='https://dx.doi.org/10.1016/j.trsl.2024.08.003' target='_blank'>10.1016/j.trsl.2024.08.003</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.trsl.2024.08.003','39181195', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.trsl.2024.08.003' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22923);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/transres/default2.aspx?pg=mainpage.html' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.trsl.2024.08.003" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is a chronic inflammatory oral disease that impaired the tooth-supporting apparatus, including gingival tissue destruction and alveolar bone resorption. The initiation of periodontitis is linked to the presence of oral bacteria, particularly P. gingivalis within pathogenic biofilms. Here, we demonstrated the central role of the autophagy regulator Transcription Factor EB (TFEB) in orchestrating autophagy activation and modulating the host immune response against P. gingivalis in periodontitis. Upregulation of TFEB expression at the protein level and heightened nuclear localization occurred during the progressive stages of periodontitis. Functionally, TFEB overexpression emerges as a potent alleviator of periodontitis-associated phenotypes, operating through the activation of autophagy and the inhibition of the NF-κB pathway in both in vivo and in vitro models. In addition, TFEB knockdown exacerbates the inflammatory response by upregulating pro-inflammatory cytokines. The dual regulatory role of TFEB in governing both autophagy and inflammatory responses unveils novel insights into periodontitis pathogenesis, positioning TFEB as a promising therapeutic target for periodontitis intervention. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TFEB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TFEB</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Leucine+Zipper+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Leucine+Zipper+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porphyromonas+gingivalis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porphyromonas gingivalis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Yang H</b>, Zhang Y, Zhang L, Tan X, Zhi M, Wang C. Wnt7B enhances the osteogenic differentiation of lipopolysaccharide-stimulated human periodontal ligament stem cells and inhibits the M1 polarization of macrophages by binding FZD4. <em class='incite-journal-name' onclick='ShowInCiteJournal(17029);'>Mol Med Rep</em> 2024;<b>30</b>:203. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39301638' target='_blank'>39301638</a> DOI: <a href='https://dx.doi.org/10.3892/mmr.2024.13327' target='_blank'>10.3892/mmr.2024.13327</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3892/mmr.2024.13327','39301638', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3892/mmr.2024.13327' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17029);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.3892/mmr.2024.13327" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis, a common oral disease characterized by the progressive infiltration of bacteria, is a leading cause of adult tooth loss. Periodontal stem cells (PDLSCs) possess good self‑renewal and multi‑potential differentiation abilities to maintain the integrity of periodontal support structure and repair defects. The present study aimed to analyze the roles of Wnt7B and frizzled4 (FZD4) in the osteogenic differentiation and macrophage polarization during periodontitis using an in vitro cell model. First, Wnt7B expression in the periodontitis‑affected gingival tissue of patients and lipopolysaccharide (LPS)‑stimulated PDLSCs was assessed using the GSE23586 dataset and western blot analysis, respectively. In Wnt7B‑overexpressing PDLSCs exposed to LPS, the capacity of osteogenic differentiation was evaluated by detecting alkaline phosphatase activity, the level of Alizarin Red S staining and the expression of genes related to osteogenic differentiation. Subsequently, conditioned medium from PDLSCs overexpressing Wnt7B was used for M0 macrophage culture. The expression of CD86 and INOS was examined using immunofluorescence staining and western blot analysis. In addition, reverse transcription‑quantitative PCR was employed to examine the expression of TNF‑α, IL‑6 and IL‑1β in macrophages. The binding between Wnt7B and FZD4 was estimated using co‑immunoprecipitation. In addition, FZD4 was silenced to perform the rescue experiments to elucidate the regulatory mechanism between Wnt7B and FZD4. The results demonstrated a decreased expression of Wnt7B in periodontitis‑affected gingival tissue and in LPS‑exposed PDLSCs. Wnt7B overexpression promoted the osteogenic differentiation of LPS‑exposed PDLSCs and suppressed the M1 polarization of macrophages. Additionally, Wnt7B bound to FZD4 and upregulated FZD4 expression. FZD4 silencing reversed the effects of Wnt7B overexpression on the osteogenic differentiation in LPS‑exposed PDLSCs and the M1 polarization of macrophages. In summary, Wnt7B plays an anti‑periodontitis role by binding FZD4 to strengthen the osteogenic differentiation of LPS‑stimulated PDLSCs and suppress the M1 polarization of macrophages. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt7B%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt7B</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dentistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dentistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22periodontology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">periodontology</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Frizzled+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Frizzled Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Frizzled+Receptors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Frizzled Receptors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Binding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Binding</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Hu Z</b>, Luo Y, Lin W, Wu X. IRF4 Suppresses Osteogenic Differentiation of Periodontal Ligament Stem Cells by Activating IL-18 Signaling Pathway in Periodontitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(168052);'>Adv Biol (Weinh)</em> 2024;<b>8</b>:e2400099. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39078121' target='_blank'>39078121</a> DOI: <a href='https://dx.doi.org/10.1002/adbi.202400099' target='_blank'>10.1002/adbi.202400099</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/adbi.202400099','39078121', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/adbi.202400099' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168052);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/31/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1002/adbi.202400099" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The present study aims to investigate the role of interferon regulatory factor 4 (IRF4) in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) and analyze the underlying signaling of these processes. In this study, IRF4 is upregulated in periodontitis periodontal ligament tissues, as compared to healthy periodontal ligament tissues. IRF4 knockdown increases cell proliferation, decreases levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-8, enhances osteogenic activity, and increases the expression of RUNX family transcription factor 2, Collagen I, and Osteocalcin in PDLSCs. The opposite results are observed in IRF4 overexpressed PDLSCs. Additionally, GSEA shows that IRF4 activates the interleukin-18 (IL-18) signaling pathway. The expressions of IL-18, B-cell translocation gene 2, interleukin-1beta, and caspase-3 are decreased by IRF4 knockdown, while increased by IRF4 overexpression. IL-18 overexpression eliminates the promoting effect of IRF4 knockdown on osteogenic differentiation of PDLSCs. In conclusion, IRF4 suppresses osteogenic differentiation of PDLSCs by activating the IL-18 signaling pathway. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PDLSCs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PDLSCs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">proliferation</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interferon+Regulatory+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interferon Regulatory Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interferon+Regulatory+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interferon Regulatory Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-18%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-18/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-18%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-18/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Wen S</b>, Zheng X, Yin W, Liu Y, Wang R, Zhao Y, Liu Z, Li C, Zeng J, Rong M. Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application. <em class='incite-journal-name' onclick='ShowInCiteJournal(21544);'>Stem Cell Res Ther</em> 2024;<b>15</b>:389. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39482701' target='_blank'>39482701</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526537' target='_blank'>PMC11526537</a> DOI: <a href='https://dx.doi.org/10.1186/s13287-024-04003-9' target='_blank'>10.1186/s13287-024-04003-9</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13287-024-04003-9','39482701', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13287-024-04003-9' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21544);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/03/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1186/s13287-024-04003-9" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis, a globally prevalent chronic inflammatory disease is characterized by the progressive degradation of tooth-supporting structures, particularly the periodontal ligament (PDL), which can eventually result in tooth loss. Despite the various clinical interventions available, most focus on symptomatic relief and lack substantial evidence of supporting the functional regeneration of the PDL. Dental stem cells (DSCs), with their homology and mesenchymal stem cell (MSC) properties, have gained significant attention as a potential avenue for PDL regeneration. Consequently, multiple therapeutic strategies have been developed to enhance the efficacy of DSC-based treatments and improve clinical outcomes. This review examines the mechanisms by which DSCs and their derivatives promote PDL regeneration, and explores the diverse applications of exogenous implantation and endogenous regenerative technology (ERT) aimed at amplifying the regenerative capacity of endogenous DSCs. Additionally, the persistent challenges and controversies surrounding DSC therapies are discussed, alongside an evaluation of the limitations in current research on the underlying mechanisms and innovative applications of DSCs in PDL regeneration with the aim of providing new insights for future development. Periodontitis, a chronic inflammatory disease, represents a major global public health concern, affecting a significant proportion of the population and standing as the leading cause tooth loss in adults. The functional periodontal ligament (PDL) plays an indispensable role in maintaining periodontal health, as its structural and biological integrity is crucial for the long-term prognosis of periodontal tissues. It is widely recognized as the cornerstone of periodontal regeneration Despite the availability of various treatments, ranging from nonsurgical interventions to guided tissue regeneration (GTR) techniques, these methods have shown limited success in achieving meaningful PDL regeneration. As a result, the inability to fully restore PDL function underscores the urgent need for innovative therapeutic strategies at reconstructing this essential structure. Stem cell therapy, known for its regenerative and immunomodulatory potential, offers a promising approach for periodontal tissue repair. Their application marks a significant paradigm shift in the treatment of periodontal diseases, opening new avenues for functional PDL regeneration. However, much of the current research has primarily focused on the regeneration of alveolar bone and gingiva, as these hard and soft tissues can be more easily evaluated through visual assessment. The complexity of PDL structure, coupled with the intricate interactions among cellular and molecular components, presents significant scientific and clinical hurdles in translating DSC research into practical therapeutic applications. This review provides a thorough exploration of DSC dynamics in periodontal regeneration, detailing their origins, properties, and derived products, while also examining their potential mechanisms and applications in PDL regeneration. It offers an in-depth analysis of the current research, landscape, acknowledging both the progress made and the challenges that remain in bridging the gap between laboratory findings and clinical implementation. Finally, the need for continued investigation into the intricate mechanisms governing DSC behavior and the optimization of their use in regenerative therapies for periodontal diseases is also emphasized. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dental+stem+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dental stem cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+ligament+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal ligament regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+cell+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem cell therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+Ligament%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal Ligament/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Projects+in+Guangzhou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2024A04J6615 Science and Technology Projects in Guangzhou</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Zou M</b>, Yang J. Identify novel therapeutic targets for type II diabetes and periodontitis: insights from single-cell analysis and Mendelian randomization analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9342);'>Front Endocrinol (Lausanne)</em> 2024;<b>15</b>:1410537. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39544234' target='_blank'>39544234</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560462' target='_blank'>PMC11560462</a> DOI: <a href='https://dx.doi.org/10.3389/fendo.2024.1410537' target='_blank'>10.3389/fendo.2024.1410537</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fendo.2024.1410537','39544234', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fendo.2024.1410537' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9342);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.frontiersin.org/people/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.3389/fendo.2024.1410537" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Periodontitis is a common complication of type II diabetes (T2D). However, the existing research cannot fully elucidate the association between them, let alone identify therapeutic targets for precise treatment of diabetic periodontitis. Therefore, we employed integrated genetic approaches such as single-cell analysis, Mendelian randomization (MR) analysis and colocalization analysis to uncover novel therapeutic targets for T2D and periodontitis. </div><div class="abstract-label">Methods</div><div class="abstract-content">This study integrated single-cell analysis, MR analysis, colocalization analysis, phenotype scanning, cell-cell communication analysis and metabolic pathway activity analysis to unveil novel therapeutic targets for periodontitis and T2D. We firstly identified core cell clusters of T2D and periodontitis, and important marker genes were selected. The causal associations between these genes and the two diseases were evaluated through MR analysis. Reverse MR analysis, colocalization analysis, additional validation and phenotype scanning further supported our findings. Finally, cell-cell communication analysis and metabolic pathway activity analysis were employed to preliminarily investigate the mechanisms of the observed causal associations. </div><div class="abstract-label">Results</div><div class="abstract-content">Through analysis of scRNA-seq data, we identified classical monocytes and intermediate monocytes as core cell subclusters. Differential analysis identified 221 differentially expressed genes (DEGs). MR analysis identified 13 genes exhibiting causal associations with T2D, and 11 causal genes with periodontitis. Colocalization analysis, reverse MR analysis, additional validation and phenotype scanning further enhanced the robustness of our results. Finally, we identified NCF1 as the core therapeutic target for T2D (OR = 1.09, 95% CI: 1.03-1.14, p = 1.85 × 10 - 3 ) and LRRC25 for T2D (OR = 0.96, 95% CI: 0.93-0.99, p = 3.44 × 10 - 2 ) and periodontitis (OR = 0.92, 95% CI: 0.84-0.99, p = 4.45 × 10 - 2 ). At last, cell-cell communication analysis indicated significant differences in functions and metabolic pathway activity between monocytes expressing or not expressing the core causal genes, which preliminarily interpreted the observed causal associations. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">This study integrated single-cell analysis, MR analysis and colocalization analysis to identified novel therapeutic targets for T2D and periodontitis. 13 causal genes were identified for T2D, and 11 for periodontitis. Among them, NCF1 and LRRC25 were regarded as core therapeutic targets. Our findings bridge the gap in the understanding of the association between T2D and periodontitis, and pave the way for targeted therapy of the two diseases. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GWAS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GWAS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mendelian+randomization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mendelian randomization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single-cell+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single-cell analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22type+II+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">type II diabetes</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mendelian+Randomization+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mendelian Randomization Analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Communication%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Communication</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Natural Science Foundation of China </a></li></ul> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Liu F</b>, Yao Y, Huang Y, Luo L, Wang Q, Chen B, Hu H. Gut microbiota and metabolic profile changes unveil the deterioration of alveolar bone inflammatory resorption with aging induced by D-galactose. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:26135. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39477973' target='_blank'>39477973</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526011' target='_blank'>PMC11526011</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-75941-w' target='_blank'>10.1038/s41598-024-75941-w</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-75941-w','39477973', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-75941-w' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/02/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1038/s41598-024-75941-w" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The global aging population has led to a rise in age-related health issues, such as malnutrition, metabolic disorders, and even immune decline. Among these concerns, periodontitis holds particular significance for the well-being of the elderly. This study aimed to investigate the impact of aging on inflammatory resorption of alveolar bone in mice with periodontitis, with a specific focus on alterations in the intestinal microenvironment. To achieve this, we established a D-galactose (D-gal)-induced aging mouse model with periodontitis and employed histopathological staining, oxidative stress, and inflammatory factors analyses to assess the severity of periodontitis and the health status. Additionally, the 16S rRNA sequencing and untargeted metabolomics analysis were employed to investigate alterations in the intestinal microbiota and metabolites. Our results showed that D-gal-induced aging mice with periodontitis experienced more pronounced alveolar bone inflammatory resorption and disruptions in the gut barrier, accompanied by an overall decline in physical condition. The microbial composition and structure of aged mice also underwent significant modifications, with a decreased Firmicutes/Bacteroidetes (F/B) ratio. Furthermore, metabolomics analysis demonstrated that D-gal-induced aging primarily influenced lipids and lipid-like molecules metabolism, and enrichment observed in the rheumatoid arthritis and histidine metabolism pathways. These findings provide further evidence that the aging process exacerbates age-related alveolar bone loss (ABL) through disturbances in intestinal homeostasis. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+bone+inflammatory+resorption%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar bone inflammatory resorption</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fecal+metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fecal metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+flora%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal flora</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Galactose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Galactose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Ribosomal%2c+16S%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Ribosomal, 16S/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Department+of+Education+of+Guizhou+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young scientific and technological talents growth project of Guizhou Provincial Department of Education (NO:Qian Jiao He KY[2022]276) Department of Education of Guizhou Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zunyi+Medical+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">New academic talents Project of Zunyi Medical University (QKHPTRC [2018]5772-010) Zunyi Medical University</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Department+of+Science+and+Technology+of+Guizhou+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">the Science and Technology Program of Guizhou Province (QKHJC-ZK [2022]-591) Department of Science and Technology of Guizhou Province</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Zhao Z</b>, Wu C, Huangfu Y, Zhang Y, Zhang J, Huang P, Dong A, Wang Y, Deng J, Wang W, Feng Z. Bioinspired Glycopeptide Hydrogel Reestablishing Bone Homeostasis through Mediating Osteoclasts and Osteogenesis in Periodontitis Treatment. <em>ACS NANO</em> 2024;<b>18</b>:29507-29521. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39401162' target='_blank'>39401162</a> DOI: <a href='https://dx.doi.org/10.1021/acsnano.4c05677' target='_blank'>10.1021/acsnano.4c05677</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acsnano.4c05677','39401162', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acsnano.4c05677' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1021/acsnano.4c05677" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Irreversible alveolar bone resorption is one of the important clinical manifestations of periodontitis, which is initiated by a plaque biofilm and exacerbated by the imbalance of osteoclast activity and osteogenesis, affecting a patient's masticatory function and resulting in a high recurrence rate of periodontitis. Herein, to reestablish bone homeostasis in periodontitis, a minocycline hydrochloride (MH)-loaded glycopeptide hydrogel (MH/GRWgel) is fabricated to mediate alveolar bone absorption through sequential antibacterial and RANKL-blocking activities. GRWgel shows an ECM-like fibrous and porous microstructure serving as a scaffold for cell proliferation and differentiation and holds the merits including injectability, self-healing properties, and good biocompatibility. After injection in situ, MH is released rapidly from the hydrogel in the early stage, demonstrating a potent antimicrobial effect to combat the biofilm in the deep periodontal pocket. Moreover, MH/GRWgel exhibits a high specific binding efficiency with RANKL to suppress osteoclast maturation by shielding the RANKL/RANK interaction and enhancing osteogenic differentiation, thereby synergistically regulating bone homeostasis. In the rat periodontitis model, MH/GRWgel significantly curtails periodontitis progression through antimicrobial activity, inhibition of alveolar bone resorption, and promotion of bone regeneration, which is superior to the treatment of a commercial gel. These findings suggest that MH/GRWgel with superiority in regulating bone homeostasis provides a promising therapeutic strategy for periodontitis. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22alveolar+bone+resorption%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">alveolar bone resorption</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antibacterial+hydrogel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antibacterial hydrogel</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glycopeptide+hydrogel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glycopeptide hydrogel</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Duenas S</b>, McGee Z, Mhatre I, Mayilvahanan K, Patel KK, Abdelhalim H, Jayprakash A, Wasif U, Nwankwo O, Degroat W, Yanamala N, Sengupta PP, Fine D, Ahmed Z. Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine. <em class='incite-journal-name' onclick='ShowInCiteJournal(10568);'>Hum Genomics</em> 2024;<b>18</b>:116. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39427205' target='_blank'>39427205</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491019' target='_blank'>PMC11491019</a> DOI: <a href='https://dx.doi.org/10.1186/s40246-024-00685-7' target='_blank'>10.1186/s40246-024-00685-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s40246-024-00685-7','39427205', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s40246-024-00685-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10568);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1186/s40246-024-00685-7" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is a highly prevalent inflammatory illness that leads to the destruction of tooth supporting tissue structures and has been associated with an increased risk of cardiovascular disease (CVD). Precision medicine, an emerging branch of medical treatment, aims can further improve current traditional treatment by personalizing care based on one's environment, genetic makeup, and lifestyle. Genomic databases have paved the way for precision medicine by elucidating the pathophysiology of complex, heritable diseases. Therefore, the investigation of novel periodontitis-linked genes associated with CVD will enhance our understanding of their linkage and related biochemical pathways for targeted therapies. In this article, we highlight possible mechanisms of actions connecting PD and CVD. Furthermore, we delve deeper into certain heritable inflammatory-associated pathways linking the two. The goal is to gather, compare, and assess high-quality scientific literature alongside genomic datasets that seek to establish a link between periodontitis and CVD. The scope is focused on the most up to date and authentic literature published within the last 10 years, indexed and available from PubMed Central, that analyzes periodontitis-associated genes linked to CVD. Based on the comparative analysis criteria, fifty-one genes associated with both periodontitis and CVD were identified and reported. The prevalence of genes associated with both CVD and periodontitis warrants investigation to assess the validity of a potential linkage between the pathophysiology of both diseases. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precision+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precision medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+Diseases%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular Diseases/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precision+Medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precision Medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genomics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genomics/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Qian X</b>, Lin X, Hu W, Zhang L, Chen W, Zhang S, Ge S, Xu X, Luo K. Intestinal homeostasis disrupted by Periodontitis exacerbates Alzheimer's Disease in APP/PS1 mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(14647);'>J Neuroinflammation</em> 2024;<b>21</b>:263. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39425119' target='_blank'>39425119</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489998' target='_blank'>PMC11489998</a> DOI: <a href='https://dx.doi.org/10.1186/s12974-024-03256-8' target='_blank'>10.1186/s12974-024-03256-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12974-024-03256-8','39425119', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12974-024-03256-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14647);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1186/s12974-024-03256-8" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis exacerbates Alzheimer's disease (AD) through multiple pathways. Both periodontitis and AD are intricately correlated to intestinal homeostasis, yet there is still a lack of direct evidence regarding whether periodontitis can regulate the progression of AD by modulating intestinal homeostasis. The current study induced experimental periodontitis in AD mice by bilaterally ligating the maxillary second molars with silk and administering Pg-LPS injections in APPswe/PS1ΔE9 (APP/PS1) mice. Behavioral tests and histological analyses of brain tissue were conducted after 8 weeks. Gut microbiota was analyzed and colon tissue were also evaluated. Then, fecal microbiota from mice with periodontitis was transplanted into antibiotic-treated mice to confirm the effects of periodontitis on AD and the potential mechanism was explored. The results indicated periodontitis exacerbated cognitive impairment and anxious behaviour in APP/PS1 mice, with increased Aβ deposition, microglial overactivation and neuroinflammation in brain. Moreover, the intestinal homeostasis of AD mice was altered by periodontitis, including affecting gut microbiota composition, causing colon inflammation and destroyed intestinal epithelial barrier. Furthermore, AD mice that underwent fecal transplantation from mice with periodontitis exhibited worsened AD progression and disrupted intestinal homeostasis. It also impaired intestinal barrier function, elevated peripheral inflammation, damaged blood-brain barrier (BBB) and caused neuroinflammation and synapses impairment. Taken together, the current study demonstrated that periodontitis could disrupt intestinal homeostasis to exacerbate AD progression potential via causing gut microbial dysbiosis, intestinal inflammation and intestinal barrier impairment to induce peripheral inflammation and damage BBB, ultimately leading to neuroinflammation and synapse impairment. It underscores the importance of maintaining both periodontal health and intestinal homeostasis to reduce the risk of AD. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer%e2%80%99s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer’s disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gut+microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gut microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyloid+beta-Protein+Precursor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyloid beta-Protein Precursor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyloid+beta-Protein+Precursor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyloid beta-Protein Precursor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Presenilin-1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Presenilin-1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">81860197 the National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Joint+Funds+for+the+Innovation+of+Science+and+Technology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2020Y9032 the Joint Funds for the Innovation of Science and Technology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Educational+Research+Project+for+Young+and+Middle-aged+Teachers+of+Fujian+Provincial+Department+of+Education%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JAT220078 the Educational Research Project for Young and Middle-aged Teachers of Fujian Provincial Department of Education</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Outstanding+Youth+Science+Fund+Project+of+National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82301103 National Outstanding Youth Science Fund Project of National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Li JM</b>, Wang XE, Xu X, Liu J, Zhang L, Feng XH, Lu RF, Xu L, Meng HX. Multifactorial analysis of factors influencing premolar mobility in stage III/IV grade C periodontitis patients ≤ 35 years of age: a cross-sectional study. <em class='incite-journal-name' onclick='ShowInCiteJournal(4087);'>BMC Oral Health</em> 2024;<b>24</b>:1232. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39415252' target='_blank'>39415252</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484426' target='_blank'>PMC11484426</a> DOI: <a href='https://dx.doi.org/10.1186/s12903-024-05039-2' target='_blank'>10.1186/s12903-024-05039-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12903-024-05039-2','39415252', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12903-024-05039-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4087);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1186/s12903-024-05039-2" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Previous studies have suggested a potential link between the crown-to-root ratio (CRR) and root morphology in patients with mild chronic periodontitis, which may be associated with tooth mobility. However, these findings have not been thoroughly investigated. Our previous study found that 76% of patients with aggressive periodontitis, particularly those with premolar involvement, exhibited abnormal root morphology, severe alveolar bone loss, and increased tooth mobility, leading to poor clinical outcomes. This study aims to investigate the specific correlations among alveolar bone resorption, root morphology, CRR, and periodontal clinical indicators with premolar mobility in stage III/IV grade C periodontitis patients aged ≤ 35 years. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">A total of 1,064 premolars from 151 stage III/IV grade C periodontitis patients aged ≤ 35 years were included in the study. Clinical periodontal parameters and radiographic measurements were recorded. Logistic regression analysis was used to explore the relationships between these indicators and tooth mobility. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Significant variations in premolar root lengths were observed, ranging from 6.80 mm to 20.96 mm. Teeth with shorter roots (mean length: 10.22 mm) exhibited grade I mobility with only 28% alveolar bone resorption, whereas those with medium-length (mean length: 12.67 mm) and longer roots (mean length: 14.91 mm) exhibited mobility at 34% and 37% bone resorption, respectively. Regression models incorporating the bone-level CRR, average probing depth, and root length demonstrated strong predictive accuracy for tooth mobility (P < 0.001, AIC = 1700.574). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Premolar mobility is influenced by variations in root length, alveolar bone resorption, and probing depth. The bone-level CRR is an effective predictor for assessing tooth mobility, especially when there are differences in root length and alveolar bone resorption. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+bone+resorption%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar bone resorption</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multifactorial+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multifactorial analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stage+III%2fIV+grade+C+periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stage III/IV grade C periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+mobility%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth mobility</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+root+morphology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth root morphology</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-Sectional+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-Sectional Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+Mobility%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth Mobility/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bicuspid%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bicuspid/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+Root%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth Root/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tooth+Root%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tooth Root/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/physiopathology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Lin B</b>, Pathak JL, Gao H, Zhou Z, Ser HL, Wu L, Lee LH, Wang L, Chen J, Zhong M. A pilot study examining periodontally healthy middle-aged humans and monkeys display different levels of alveolar bone resorption, gingival inflammatory infiltrate, and salivary microbiota profile. <em class='incite-journal-name' onclick='ShowInCiteJournal(19324);'>PLoS One</em> 2024;<b>19</b>:e0311282. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39413077' target='_blank'>39413077</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482700' target='_blank'>PMC11482700</a> DOI: <a href='https://dx.doi.org/10.1371/journal.pone.0311282' target='_blank'>10.1371/journal.pone.0311282</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1371/journal.pone.0311282','39413077', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1371/journal.pone.0311282' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19324);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1371/journal.pone.0311282" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Monkeys are an appropriate model for periodontal research owing to their similar dental anatomy and physiology unlike humans. Extensive literature exists on pathological periodontitis in monkeys and humans, although concerns regarding whether healthy middle-aged monkeys and humans display the same periodontal and oral microbial status remains unclear. </div><div class="abstract-label">AIMS AND OBJECTIVES</div><div class="abstract-content">The current study aimed to compare alveolar bone resorption, gingival inflammatory infiltrate, and salivary microbiota profile in periodontally healthy middle-aged humans and monkeys. </div><div class="abstract-label">METHODS</div><div class="abstract-content">CBCT examination and histological analysis were performed to compare the periodontal status in middle-aged healthy humans and monkeys. Oral saliva16S rRNA sequencing was performed to analyze the oral microbial profile. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The alveolar resorption was compared between humans and monkeys, to determine the periodontal health. The percentage attachment of attachment loss was more around the posteriors teeth in humans when compared to monkeys (p<0.05). The degree of gingival inflammation was analyzed in both the groups, the expression of CD 34,45was higher in humans. 16S rRNA analysis demonstrated less diversity of salivary microorganisms in humans than in monkeys. The relative abundance of Aggregatibacter, Haemophilus, Gemella, and Porphyromonas at the genus level was significantly less in humans than in monkeys (p(<0.05). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The periodontally healthy middle-aged humans and monkeys display different alveolar bone resorption and gingival inflammatory infiltrate levels. Furthermore, the salivary microbiota profile showed distinctly different oral microbiomes in these two primates. Our results suggest that the difference in alveolar bone status and gingival inflammatory infiltrate in healthy humans and monkeys might be associated with the diversity of the oral microbiome. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Saliva%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Saliva/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pilot+Projects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pilot Projects</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alveolar+Bone+Loss%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alveolar Bone Loss/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Ribosomal%2c+16S%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Ribosomal, 16S/genetics</a></li><li><a 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Guangdong province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Higher+Education+Young+Innovative+Talent+Program+of+Guangdong+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Higher Education Young Innovative Talent Program of Guangdong Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Guangdong+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural Science Foundation of Guangdong Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High-level+Hospital+Construction+Project+of+Guangdong+Provincial+People%e2%80%99s+Hospital%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High-level Hospital Construction Project of Guangdong Provincial People’s Hospital</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Xiao L</b>, Mochizuki M, Shimamura N, Sunada K, Nakahara T. Interplay of co-cultured chimeric adipose and gingival tissues exacerbates inflammatory dysfunction relevant to periodontal and metabolic conditions. <em class='incite-journal-name' onclick='ShowInCiteJournal(16199);'>Life Sci</em> 2024;<b>355</b>:123009. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39197574' target='_blank'>39197574</a> DOI: <a href='https://dx.doi.org/10.1016/j.lfs.2024.123009' target='_blank'>10.1016/j.lfs.2024.123009</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.lfs.2024.123009','39197574', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.lfs.2024.123009' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16199);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.lfs.2024.123009" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Adipose tissue dysfunction is a key feature of metabolic syndrome, which increases the risk of periodontitis, an inflammatory disease induced by bacteria that affects the gingiva and other components of periodontal tissue. Recent studies indicate that molecules from inflamed periodontal tissue contribute to adipose tissue dysfunction. However, the cellular mechanisms and interactions between adipose tissue and gingiva driving the progression of metabolic and periodontal conditions remain unclear. To address this, we developed a chimeric (mouse/human) co-culture tissue model (which identifies the origins of species-specific cytokines) to investigate these interactions. Using tissue-specific functional cells and immunocytes, we constructed equivalents of adipose tissue (ATE) and gingiva (GTE), co-cultivating them under inflammatory conditions induced by bacterial endotoxin, lipopolysaccharide (LPS). Our findings showed that exposure to LPS resulted in a notable reduction in lipid accumulation, GLUT4 expression, and adiponectin secretion in ATE, along with increased macrophage colonies forming around lipid droplets, as well as elevated levels of triglyceride, leptin, and IL-6. In GTE, LPS triggered significant inflammatory responses, characterized by increased macrophage accumulation, elevated COX-2 expression, and heightened secretion of inflammatory cytokines. LPS also reduced epithelial thickness and the expression of keratin 19 and collagen IV, indicating impaired barrier function and gingival integrity. Co-culturing ATE with GTE exacerbated these LPS-induced harmful effects in both tissues. In conclusion, our findings suggest that interplay between gingiva and adipose tissue can intensify the inflammatory and dysfunctional changes caused by LPS. This co-culture tissue model offers a valuable tool for future studies on periodontitis and metabolic syndrome. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Collagen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Collagen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+engineering%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue engineering</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gingiva%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gingiva/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gingiva%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gingiva/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coculture+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coculture Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Syndrome%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Syndrome/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Chen H</b>, Liu N, Hu S, Li X, He F, Chen L, Xu X. Yeast β-glucan-based nanoparticles loading methotrexate promotes osteogenesis of hDPSCs and periodontal bone regeneration under the inflammatory microenvironment. <em class='incite-journal-name' onclick='ShowInCiteJournal(4492);'>Carbohydr Polym</em> 2024;<b>342</b>:122401. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39048236' target='_blank'>39048236</a> DOI: <a href='https://dx.doi.org/10.1016/j.carbpol.2024.122401' target='_blank'>10.1016/j.carbpol.2024.122401</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.carbpol.2024.122401','39048236', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.carbpol.2024.122401' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4492);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.carbpol.2024.122401" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The regeneration of absorbed alveolar bone and reconstruction of periodontal support tissue are huge challenges in the clinical treatment of periodontitis due to the limited regenerative capacity of alveolar bone. It is essential to regulate inflammatory reaction and periodontal cell differentiation. Based on the anti-inflammatory effect of baker's yeast β-glucan (BYG) with biosafety by targeting macrophages, the BYG-based nanoparticles loading methotrexate (cBPM) were fabricated from polyethylene glycol-grafted BYG through chemical crosslinking for treatment of periodontitis. In our findings, cBPM promoted osteogenesis of human dental pulp stem cells (hDPSCs) under inflammatory microenvironment, characterized by the enhanced expression of osteogenesis-related Runx2 and activation of mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/Erk) pathway in vitro. Animal experiments further demonstrate that cBPM effectively promoted periodontal bone regeneration and achieved in a better effect of recovery indicated by 19.2 % increase in tissue volume, 7.1 % decrease in trabecular separation, and a significant increase in percent bone volume and trabecular thickness, compared with the model group. Additionally, cBPM inhibited inflammation and repaired alveolar bone by transforming macrophage phenotype from inflammatory M1 to anti-inflammatory M2. This work provides an alternative strategy for the clinical treatment of periodontitis through BYG-based delivery nanoplatform of anti-inflammatory drugs. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ascorbic+acid+(PubChem+CID%3a+54670067)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ascorbic acid (PubChem CID: 54670067)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dexamethasone+(PubChem+CID%3a+5743)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dexamethasone (PubChem CID: 5743)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eosin+(PubChem+CID%3a+11048)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eosin (PubChem CID: 11048)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ethanol+(PubChem+CID%3a+702)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ethanol (PubChem CID: 702)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematoxylin+(PubChem+CID%3a+442514)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematoxylin (PubChem CID: 442514)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+dental+pulp+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human dental pulp stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharide+(PubChem+CID%3a+11970143)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharide (PubChem CID: 11970143)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+transformation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage transformation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methotrexate+(PubChem+CID%3a+126941)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methotrexate (PubChem CID: 126941)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptomycin+(PubChem+CID%3a+19649)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptomycin (PubChem CID: 19649)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yeast+%ce%b2-glucan-based+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yeast β-glucan-based nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22beta-Glucans%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">beta-Glucans/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22beta-Glucans%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">beta-Glucans/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dental+Pulp%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dental Pulp/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dental+Pulp%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dental Pulp/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methotrexate%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methotrexate/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methotrexate%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methotrexate/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Carriers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Carriers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Adewoyin M</b>, Hamarsha A, Akinsola R, Teoh SL, Azmai MNA, Abu Bakar N, Nasruddin NS. Intraperitoneal Injection of the <i>Porphyromonas gingivalis</i> Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and Histopathological Changes in the Brains of Adult Zebrafish. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:11025. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39456807' target='_blank'>39456807</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506875' target='_blank'>PMC11506875</a> DOI: <a href='https://dx.doi.org/10.3390/ijms252011025' target='_blank'>10.3390/ijms252011025</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms252011025','39456807', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms252011025' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.3390/ijms252011025" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Porphyromonas gingivalis is the major pathogenic bacteria found in the subgingival plaque of patients with periodontitis, which leads to neuroinflammation. The bacteria destroy periodontal tissue through virulence factors, which are retained in the bacteria's outer membrane vesicles (OMV). This study aimed to determine the real-time effect of an intraperitoneal injection of P. gingivalis OMV on the production and expression of inflammatory markers and histopathological changes in adult zebrafishes' central nervous systems (CNS). Following the LD50 (21 µg of OMV), the zebrafish were injected intraperitoneally with 18 µg of OMVs, and the control group were injected with normal saline at seven different time points. Brains of experimental zebrafish were dissected at desired time points for colorimetric assays, ELISA, and histology. This study discovered that nitric oxide and PGE2 were significantly increased at 45 min, while IL-1β and IL-6 were expressed at subsequent 12 h and 24 h time points, respectively. Histopathological changes such as blood coagulation, astrocytosis, edema, spongiosis, and necrosis were observed between the 6hour and 24 h time points. The two apoptotic enzymes, caspases 3 and 9, were not expressed at any point. In summary, the OMV-induced neuroinflammatory responses and histopathological changes in adult zebrafish were time-point dependent. This study will enrich our understanding of the mechanism of P. gingivalis OMVs in neuroinflammation in a zebrafish model, most especially the timing of the expression of inflammatory mediators in relation to observable changes in brain tissues. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22P.+gingivalis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P. gingivalis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroinflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22outer+membrane+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">outer membrane vesicles</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zebrafish%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zebrafish</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porphyromonas+gingivalis%2fpathogenicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porphyromonas gingivalis/pathogenicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injections%2c+Intraperitoneal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injections, Intraperitoneal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+Outer+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial Outer Membrane/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-1beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-1beta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-6%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-6/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitric+Oxide%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitric Oxide/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fundamental+Research+Grant+Scheme(FRGS)%2c+Ministry+of+Education%2c+Malaysia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FRGS/1/2020/SKK0/UKM/02/10.. Fundamental Research Grant Scheme(FRGS), Ministry of Education, Malaysia</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Gu X</b>, Luo S, Sun J, Jin F, Chen Z, Song J. Association between "a body shape index" (ABSI) with periodontitis in a hypertension population from the NHANES 2009-2014. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:23378. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39379534' target='_blank'>39379534</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461872' target='_blank'>PMC11461872</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-73998-1' target='_blank'>10.1038/s41598-024-73998-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-73998-1','39379534', 'Periodontitis/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-73998-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1038/s41598-024-73998-1" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">A body Shape index (ABSI), defined as waist circumference (WC)/(body mass index (BMI)2/3 × height1/2), is unique in that the ABSI is positively associated with visceral obesity and is independent of BMI. The ABSI has also been shown to be positively and linearly correlated with the amount of visceral adiposity in the general population and with all-cause and cardiovascular disease (CVD). However, it is uncertain whether ABSI is associated with periodontitis in hypertensive patients. A cross-sectional study of 2,482 hypertensive patients (mean age 65.2 ± 9.1 years) was conducted using the ABSI Z score, periodontitis as a dichotomous variable, the ABSI Z score as a continuous variable, and multiple covariates such as age, gender, and race. The data were analyzed using descriptive statistics, multiple regression model, subgroup analysis with EmpowerStats (version 4.2), and curve transformation plots were generated. In multiple regression model analysis, ABSI Z score showed a significant positive association with periodontitis in the hypertensive population in all three models. When ABSI Z score was divided into low, moderate, and high three groups, we observed that those with the highest ABSI Z score had a 20% increased risk of periodontitis among people with hypertension (OR 1.2; 95% CI 1.0, 1.5; p = 0.046). We used smooth curve fitting to confirm the results and found that these results were still supported, and additional subgroup analyses showed that the positive association between ABSI Z score and periodontitis in hypertensive population was stable and consistent in the general population. The present cross-sectional investigation showed a positive association between ABSI Z score and periodontitis in a hypertensive population. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22A+body+shape+index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">A body shape index</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ABSI+Z+score%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ABSI Z score</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-sectional+study%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-sectional study</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHANES%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NHANES</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypertension%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypertension/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypertension%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypertension/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a 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right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 76 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a 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id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Periodontitis/pathology (1888 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Periodontitis/pathology (1888 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>