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100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Patrick Moriarty</h3></div><div class="js-work-strip profile--work_container" data-work-id="115278656"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115278656/1445_Growth_factor_levels_in_the_diabetic_vitreous_Correlation_with_type_of_diabetes_and_neovascular_activity"><img alt="Research paper thumbnail of 1445 Growth factor levels in the diabetic vitreous: Correlation with type of diabetes and neovascular activity" class="work-thumbnail" src="https://attachments.academia-assets.com/111732395/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115278656/1445_Growth_factor_levels_in_the_diabetic_vitreous_Correlation_with_type_of_diabetes_and_neovascular_activity">1445 Growth factor levels in the diabetic vitreous: Correlation with type of diabetes and neovascular activity</a></div><div class="wp-workCard_item"><span>Vision Research</span><span>, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da2f70540bd2061412fa09b3ee873209" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111732395,"asset_id":115278656,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111732395/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span 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href="https://www.academia.edu/110605638/Production_of_IGF_I_and_IGF_binding_proteins_by_retinal_cells_in_vitro">Production of IGF-I and IGF binding proteins by retinal cells in vitro</a></div><div class="wp-workCard_item"><span>British Journal of Ophthalmology</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Insulin-like growth factor I (IGF-I) and its associated binding proteins (IGFBPs) have been ident...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Insulin-like growth factor I (IGF-I) and its associated binding proteins (IGFBPs) have been identified in retinal tissues but their precise cellular origin remains unclear. The aim of this study was to examine the ability of three retinal cell types (microvascular endothelial cells, pericytes, and pigment epithelial cells) and a non-retinal cell type (Tenon's fibroblasts) to produce IGF-I and cell specific IGFBPs in vitro. Using a radioimmunoassay we demonstrated that all four cell types produce IGF-I and that this production continued over a 72 hour period. In addition, western ligand blotting revealed that each cell type produced at least one IGFBP and that each cell type produced a different IGFBP profile. Endothelial cells produced a 24 kDa band only, pericytes produced both a 24 kDa and a 34 kDa band, retinal pigment epithelial cells produced a 38-41 kDa band, while fibroblasts produced both a 24 kDa and a 30 kDa band. Laser scanning densitometry demonstrated that in the majority of experiments the IGFBPs accumulated in the culture medium over a 72 hour period. Neither IGF-I nor IGFBPs were observed in cell lysates indicating de novo synthesis and secretion in vitro. These results suggest an autocrine/paracrine function for IGF-I and its associated binding proteins which may play a significant role in both retinal physiology and disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="abf735b66a651efae0092a858f877cd3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108371482,"asset_id":110605638,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108371482/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110605638"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110605638"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110605638; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="107869855"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/107869855/Modulators_and_milieu_in_preretinal_neovascularisation"><img alt="Research paper thumbnail of Modulators and milieu in preretinal neovascularisation" class="work-thumbnail" src="https://attachments.academia-assets.com/106412313/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/107869855/Modulators_and_milieu_in_preretinal_neovascularisation">Modulators and milieu in preretinal neovascularisation</a></div><div class="wp-workCard_item"><span>Eye</span><span>, 1992</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">gin of ocular growth factors and attempt to reconcile otherwise conflicting hypotheses regarding ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">gin of ocular growth factors and attempt to reconcile otherwise conflicting hypotheses regarding the pathophy siology of preretinal neovascularisation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4275bdba458a66097beefb9eb4ace391" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":106412313,"asset_id":107869855,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/106412313/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="107869855"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="107869855"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 107869855; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=107869855]").text(description); $(".js-view-count[data-work-id=107869855]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 107869855; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='107869855']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4275bdba458a66097beefb9eb4ace391" } } $('.js-work-strip[data-work-id=107869855]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":107869855,"title":"Modulators and milieu in preretinal neovascularisation","internal_url":"https://www.academia.edu/107869855/Modulators_and_milieu_in_preretinal_neovascularisation","owner_id":173435165,"coauthors_can_edit":true,"owner":{"id":173435165,"first_name":"Patrick","middle_initials":null,"last_name":"Moriarty","page_name":"PatrickMoriarty13","domain_name":"independent","created_at":"2020-10-07T07:17:57.445-07:00","display_name":"Patrick Moriarty","url":"https://independent.academia.edu/PatrickMoriarty13"},"attachments":[{"id":106412313,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/106412313/thumbnails/1.jpg","file_name":"eye1992122.pdf","download_url":"https://www.academia.edu/attachments/106412313/download_file","bulk_download_file_name":"Modulators_and_milieu_in_preretinal_neov.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/106412313/eye1992122-libre.pdf?1696864094=\u0026response-content-disposition=attachment%3B+filename%3DModulators_and_milieu_in_preretinal_neov.pdf\u0026Expires=1739809309\u0026Signature=AYQCEHL1SxK0PSxEc9OzGh1rzhzn5VD6Skiv--nS18a4dyqbryifc-IeTWTDkjWzLN-53WtbLy7hUUBhTQFgIh2hFT5qYfI11K6mvungwqy337CR3GF2uTOkJLnyYLNqCEHJpHwF275eNrYLD6gVqRq9sa0VPeiNpo0frQWKI9-w9~KE8Lhnn1xLsVKNXbTx5RLAeHuAb5zItr95p415OgL7uqPRpWbgkDjESm8TzGR~NL4nXtf4r~JgGQji8DgJezxJyT-dxTHGJVO1IDwLgbi8dht9ZE-bma36gP-CTdI3ahIaMONR6gaSv5e--hwW9FjRgnaPrN7MeWebEb8hvg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104395714"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104395714/Intravitreal_growth_factors_in_proliferative_diabetic_retinopathy_correlation_with_neovascular_activity_and_glycaemic_management"><img alt="Research paper thumbnail of Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management" class="work-thumbnail" src="https://attachments.academia-assets.com/104137626/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104395714/Intravitreal_growth_factors_in_proliferative_diabetic_retinopathy_correlation_with_neovascular_activity_and_glycaemic_management">Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management</a></div><div class="wp-workCard_item"><span>British Journal of Ophthalmology</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim-Many growth factors are implicated in proliferative diabetic retinopathy (PDR). It was decide...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim-Many growth factors are implicated in proliferative diabetic retinopathy (PDR). It was decided to test the hypothesis that no one factor is predominant but that a regular profile of levels of diVerent growth factors might be operating, and that the profile might diVer according to whether or not insulin therapy was part of the patient's glycaemic management. The levels of several growth factors in vitrectomy samples were therefore determined from diabetic patients with tractional, non-haemorrhagic sequelae of PDR and these levels were correlated with (a) each other (growth factor profile), (b) neovascular activity, and (c) the method of glycaemic management (insulin treated (IT) or non-insulin treated (NIT)). Methods-72 samples of vitreous were obtained from either diabetic patients with PDR (n = 51) or non-diabetic (control) patients (n = 21). Levels of bFGF, IGF-I, EGF, and insulin were determined by radioimmunoassay; levels of TGF-2 by ELISA; and levels of IGF-I binding protein by western ligand blotting. The data were analysed using appropriate statistics. Results-There was no regular growth factor profile. bFGF levels were significantly greater in vitreous from NIT patients compared with IT patients and controls. The highest levels of bFGF were found in NIT patients with actively vascularised membranes. TGF-2 levels were significantly greater in vitreous from IT patients compared with NIT patients and controls The highest levels of TGF-2 were found in IT patients with actively vascularised membranes. IGF-I levels were significantly greater in diabetics (irrespective of insulin treatment) than non-diabetics and the highest levels of IGF-I were found in IT patients with actively vascularised membranes. A 34 kDa IGFBP was the predominant IGFBP identified in vitreous and was found to be elevated in diabetics patients. Conclusion-In PDR there is a correlation between intravitreal growth factor levels and both disease state (whether active or fibrotic) and method of glycaemic management.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e506de911be3e6396e00244af94ed88" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104137626,"asset_id":104395714,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104137626/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104395714"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104395714"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104395714; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100641919"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100641919/Effect_of_Hypoxia_on_the_Proliferation_of_Microvascular_Cells_in_Vitro"><img alt="Research paper thumbnail of Effect of 'Hypoxia' on the Proliferation of Microvascular Cells in Vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/101406682/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100641919/Effect_of_Hypoxia_on_the_Proliferation_of_Microvascular_Cells_in_Vitro">Effect of 'Hypoxia' on the Proliferation of Microvascular Cells in Vitro</a></div><div class="wp-workCard_item"><span>Experimental Eye Research</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This study investigated the effect of hypoxia on the proliferation of microvascular endothelial c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This study investigated the effect of hypoxia on the proliferation of microvascular endothelial cells in the brain. Endothelial cells derived from microvessels of Mongolian gerbil brain and control cells (3T3) were incubated for 7 days under various hypoxic and normoxic conditions at 37&deg;C. The pro liferation of endothelial cells was inhibited by severe hypoxia, but stimulated by moderate hypoxia. No significant effect of hypoxia on the proliferation of control cells was observed. Endothelial cell-con ditioned medium cultured under moderate hypoxia did not affect the growth of endothelial cells. The stimulatory effect of moderate hypoxia on the proliferation of cultured endothelial cells is due to an inherent property of brain endothelial cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e50ee5d60706078584bffcea768cd890" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101406682,"asset_id":100641919,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101406682/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100641919"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100641919"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100641919; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100641918"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100641918/Effect_of_varying_oxygen_concentrations_on_the_proliferation_of_retinal_microvascular_cells_in_vitro"><img alt="Research paper thumbnail of Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/101406683/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100641918/Effect_of_varying_oxygen_concentrations_on_the_proliferation_of_retinal_microvascular_cells_in_vitro">Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitro</a></div><div class="wp-workCard_item"><span>Experimental Eye Research</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Microvascular fragments and pure cultures of either retinal microvascular endothelial cells, reti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Microvascular fragments and pure cultures of either retinal microvascular endothelial cells, retinal pericytes or Tenon's capsule fibroblasts were grown on a gas permeable substrate while exposed to varying oxygen concentrations (5, 10, 20,40 and 9 5 y0 oxygen). For all three cell types cell proliferation was greatest under the lowest oxygen concentration and decreased as the oxygen concentration increased. The decrease in the proliferative ability of cells exposed to the higher oxygen concentrations could be reversed if the cells were returned to a normoxic environment. Endothelial cells were the most sensitive to changes in oxygen tensions showing a proliferative response after 24 hr exposure as opposed to 48 hr for pericytes and fibroblasts. These results suggest a direct mechanism by which the intra-vitreal and intra-retinal oxygen tension may influence both the development of preretinal new vessels (in response to retinal ischaemia) and also the regression of neovascularization following scatter photocoagulation or vitrectomy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da9413d10da10ad51b0bb4880c02aa69" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101406683,"asset_id":100641918,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101406683/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100641918"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100641918"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100641918; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100641915"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100641915/Oxygen_modulates_production_of_bFGF_and_TGF_%CE%B2_by_retinal_cells_in_vitro"><img alt="Research paper thumbnail of Oxygen modulates production of bFGF and TGF-尾 by retinal cells in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/101406667/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100641915/Oxygen_modulates_production_of_bFGF_and_TGF_%CE%B2_by_retinal_cells_in_vitro">Oxygen modulates production of bFGF and TGF-尾 by retinal cells in vitro</a></div><div class="wp-workCard_item"><span>Experimental Eye Research</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vasoproliferative retinopathies result from retinal capillary non-perfusion and consequent inner ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vasoproliferative retinopathies result from retinal capillary non-perfusion and consequent inner retinal hypoxia. However, it is not known whether oxygen mediates vasoproliferation directly (at the nuclear level) or indirectly by regulating the production of growth factors. We have investigated the effect of oxygen on the production of basic fibroblast growth factor and transforming-growth-factor-beta by a variety of retinal cell types in culture. Confluent cultures were maintained for 48 hr under varying oxygen tensions ranging from 135 to 18 mmHg. A reduction in basic fibroblast growth factor levels was observed in the cell lysates and extracellular matrix from retinal microvascular endothelial cell, retinal microvascular pericyte and retinal pigment epithelial cell cultures when the oxygen tension of the medium was reduced from 135 to 18 mmHg. Levels of basic fibroblast growth factor in conditioned media from microvascular endothelial and retinal pigment epithelial cell cultures also decreased when the oxygen tension of the medium was reduced from 135 to 18 mmHg. Total transforming-growth-factorbeta (and specifically isoforms 1 and 2) in the conditioned media from all three cell types was similarly modulated by oxygen i.e. it decreased as the oxygen tension of the medium was reduced from 135 to 18 mmHg. In contrast, the steady state messenger RNA levels for both basic fibroblast growth factor and transforming-growth-factor-betal genes in RPE ceils increased significantly when the oxygen tension of the medium was reduced from 135 to 18 mmHg. These results support the putative role of oxygen in influencing the balance of growth factors during the development of preretinal new vessels.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efcf4c569f4bcfd385b43eb7d6663cac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101406667,"asset_id":100641915,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101406667/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100641915"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100641915"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100641915; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93345372"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/93345372/The_effect_of_scatter_laser_photocoagulation_on_intravitreal_levels_of_growth_factors_in_the_miniature_pig"><img alt="Research paper thumbnail of The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/93345372/The_effect_of_scatter_laser_photocoagulation_on_intravitreal_levels_of_growth_factors_in_the_miniature_pig">The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig</a></div><div class="wp-workCard_item"><span>Current Eye Research</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To characterise changes in intravitreal growth factor profiles following retinal photocoagulation...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To characterise changes in intravitreal growth factor profiles following retinal photocoagulation in the miniature pig. Miniature pig eyes underwent scatter photocoagulation by either diode infrared or emerald green laser. Animals were sacrificed at various times (up to 42 days) post-laser. The eyes were than removed and vitreous samples analysed for basic fibroblast growth factor, insulin-like growth factor-I and epidermal growth factor by radioimmunoassay, transforming growth factor-beta 2 by ELISA and insulin-like growth factor binding proteins using Western ligand blotting. Vitreous transforming growth factor-beta 2 levels were decreased at 1 h post diode laser and at 4 and 7 days post emerald laser but returned to normal by 21 and 42 days respectively. Vitreous insulin-like growth factor-I levels increased at 4 and 7 days post diode and emerald laser respectively but returned to normal by 21 days. Insulin-like growth factor Western ligand blotting demonstrated that a 34 kDa insulin-like growth factor binding protein was predominant in the pig vitreous; the levels of this binding protein followed an identical trend to those observed for insulin-like growth factor-I. No changes in vitreous levels of either basic fibroblast growth factor or epidermal growth factor were observed following laser treatment. Our results demonstrate a significant shift in the balance of intravitreal growth factors following retinal laser photocoagulation. Such changes may be pertinent to the regression of preretinal new vessels after laser photocoagulation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93345372"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93345372"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93345372; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=93345372]").text(description); $(".js-view-count[data-work-id=93345372]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 93345372; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='93345372']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=93345372]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":93345372,"title":"The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig","internal_url":"https://www.academia.edu/93345372/The_effect_of_scatter_laser_photocoagulation_on_intravitreal_levels_of_growth_factors_in_the_miniature_pig","owner_id":173435165,"coauthors_can_edit":true,"owner":{"id":173435165,"first_name":"Patrick","middle_initials":null,"last_name":"Moriarty","page_name":"PatrickMoriarty13","domain_name":"independent","created_at":"2020-10-07T07:17:57.445-07:00","display_name":"Patrick Moriarty","url":"https://independent.academia.edu/PatrickMoriarty13"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="86692963"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/86692963/Protein_Kinase_C_Isoenzyme_Expression_in_Retinal_Cells"><img alt="Research paper thumbnail of Protein Kinase C Isoenzyme Expression in Retinal Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/86692963/Protein_Kinase_C_Isoenzyme_Expression_in_Retinal_Cells">Protein Kinase C Isoenzyme Expression in Retinal Cells</a></div><div class="wp-workCard_item"><span>Ophthalmic Research</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Protein kinase C (PKC) is involved in both the physiological and pathophysiological processes in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Protein kinase C (PKC) is involved in both the physiological and pathophysiological processes in the retina and plays an important role in signal transduction. The aim of this study was to determine the PKC isoenzyme profile in three retinal cell types in culture, namely RPE cells, pericytes and retinal microvascular endothelial cells. Confluent cultures were lysed and isoenzyme expression detected by Western blotting. PKC isoenzymes 伪, 尾2 and 未 were observed for all three cell types while 尾1 was specific for RPE cells. This study has characterised the PKC isoenzyme profile in three retinal cell types and suggests that defining the cell-specific isoenzyme pattern is an important step in understanding their precise physiological role and regulation in the retina.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="86692963"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="86692963"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 86692963; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=86692963]").text(description); $(".js-view-count[data-work-id=86692963]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 86692963; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='86692963']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115278656]").text(description); $(".js-view-count[data-work-id=115278656]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115278656; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115278656']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "da2f70540bd2061412fa09b3ee873209" } } $('.js-work-strip[data-work-id=115278656]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115278656,"title":"1445 Growth factor levels in the diabetic vitreous: Correlation with type of diabetes and neovascular activity","internal_url":"https://www.academia.edu/115278656/1445_Growth_factor_levels_in_the_diabetic_vitreous_Correlation_with_type_of_diabetes_and_neovascular_activity","owner_id":173435165,"coauthors_can_edit":true,"owner":{"id":173435165,"first_name":"Patrick","middle_initials":null,"last_name":"Moriarty","page_name":"PatrickMoriarty13","domain_name":"independent","created_at":"2020-10-07T07:17:57.445-07:00","display_name":"Patrick Moriarty","url":"https://independent.academia.edu/PatrickMoriarty13"},"attachments":[{"id":111732395,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111732395/thumbnails/1.jpg","file_name":"aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS8wMDQyNjk4OTk1OTAxMjIx.pdf","download_url":"https://www.academia.edu/attachments/111732395/download_file","bulk_download_file_name":"1445_Growth_factor_levels_in_the_diabeti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111732395/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS8wMDQyNjk4OTk1OTAxMjIx-libre.pdf?1708637847=\u0026response-content-disposition=attachment%3B+filename%3D1445_Growth_factor_levels_in_the_diabeti.pdf\u0026Expires=1739809309\u0026Signature=fYDfGw3SH3FjYWaqLX1qtAOuHmNnxFuLBJyb71LrebSu1pDCrvVqJAoG4q4PldJHam-wF2kBaTQEcyezIONozL0mRV8kOErkuf0wTuwlJ3Q8pvqYuClY~~5zNOzM2QVrgAPwCOo~Lg2BfsihcSQ0XxmeYMLNSsk98AtiOmuQILma1DVnajvYM5strAjGRNc-u5JX8VO3KBulbYT9eX~0CEFBfm93Aw5I5eOzbe9OSN91omBw70991qrt42cQW2eYxBSyr52aWsYK8PXnkN12RzmlmWPIZJ7TZiRYOREx8RTdNm~H95RWK~Vs1yXagswEscErXuurudQazoftEfg1DQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110605638"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110605638/Production_of_IGF_I_and_IGF_binding_proteins_by_retinal_cells_in_vitro"><img alt="Research paper thumbnail of Production of IGF-I and IGF binding proteins by retinal cells in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/108371482/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110605638/Production_of_IGF_I_and_IGF_binding_proteins_by_retinal_cells_in_vitro">Production of IGF-I and IGF binding proteins by retinal cells in vitro</a></div><div class="wp-workCard_item"><span>British Journal of Ophthalmology</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Insulin-like growth factor I (IGF-I) and its associated binding proteins (IGFBPs) have been ident...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Insulin-like growth factor I (IGF-I) and its associated binding proteins (IGFBPs) have been identified in retinal tissues but their precise cellular origin remains unclear. The aim of this study was to examine the ability of three retinal cell types (microvascular endothelial cells, pericytes, and pigment epithelial cells) and a non-retinal cell type (Tenon's fibroblasts) to produce IGF-I and cell specific IGFBPs in vitro. Using a radioimmunoassay we demonstrated that all four cell types produce IGF-I and that this production continued over a 72 hour period. In addition, western ligand blotting revealed that each cell type produced at least one IGFBP and that each cell type produced a different IGFBP profile. Endothelial cells produced a 24 kDa band only, pericytes produced both a 24 kDa and a 34 kDa band, retinal pigment epithelial cells produced a 38-41 kDa band, while fibroblasts produced both a 24 kDa and a 30 kDa band. Laser scanning densitometry demonstrated that in the majority of experiments the IGFBPs accumulated in the culture medium over a 72 hour period. Neither IGF-I nor IGFBPs were observed in cell lysates indicating de novo synthesis and secretion in vitro. These results suggest an autocrine/paracrine function for IGF-I and its associated binding proteins which may play a significant role in both retinal physiology and disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="abf735b66a651efae0092a858f877cd3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108371482,"asset_id":110605638,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108371482/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110605638"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110605638"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110605638; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="107869855"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/107869855/Modulators_and_milieu_in_preretinal_neovascularisation"><img alt="Research paper thumbnail of Modulators and milieu in preretinal neovascularisation" class="work-thumbnail" src="https://attachments.academia-assets.com/106412313/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/107869855/Modulators_and_milieu_in_preretinal_neovascularisation">Modulators and milieu in preretinal neovascularisation</a></div><div class="wp-workCard_item"><span>Eye</span><span>, 1992</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">gin of ocular growth factors and attempt to reconcile otherwise conflicting hypotheses regarding ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">gin of ocular growth factors and attempt to reconcile otherwise conflicting hypotheses regarding the pathophy siology of preretinal neovascularisation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4275bdba458a66097beefb9eb4ace391" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":106412313,"asset_id":107869855,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/106412313/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="107869855"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="107869855"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 107869855; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=107869855]").text(description); $(".js-view-count[data-work-id=107869855]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 107869855; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='107869855']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4275bdba458a66097beefb9eb4ace391" } } $('.js-work-strip[data-work-id=107869855]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":107869855,"title":"Modulators and milieu in preretinal neovascularisation","internal_url":"https://www.academia.edu/107869855/Modulators_and_milieu_in_preretinal_neovascularisation","owner_id":173435165,"coauthors_can_edit":true,"owner":{"id":173435165,"first_name":"Patrick","middle_initials":null,"last_name":"Moriarty","page_name":"PatrickMoriarty13","domain_name":"independent","created_at":"2020-10-07T07:17:57.445-07:00","display_name":"Patrick Moriarty","url":"https://independent.academia.edu/PatrickMoriarty13"},"attachments":[{"id":106412313,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/106412313/thumbnails/1.jpg","file_name":"eye1992122.pdf","download_url":"https://www.academia.edu/attachments/106412313/download_file","bulk_download_file_name":"Modulators_and_milieu_in_preretinal_neov.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/106412313/eye1992122-libre.pdf?1696864094=\u0026response-content-disposition=attachment%3B+filename%3DModulators_and_milieu_in_preretinal_neov.pdf\u0026Expires=1739809309\u0026Signature=AYQCEHL1SxK0PSxEc9OzGh1rzhzn5VD6Skiv--nS18a4dyqbryifc-IeTWTDkjWzLN-53WtbLy7hUUBhTQFgIh2hFT5qYfI11K6mvungwqy337CR3GF2uTOkJLnyYLNqCEHJpHwF275eNrYLD6gVqRq9sa0VPeiNpo0frQWKI9-w9~KE8Lhnn1xLsVKNXbTx5RLAeHuAb5zItr95p415OgL7uqPRpWbgkDjESm8TzGR~NL4nXtf4r~JgGQji8DgJezxJyT-dxTHGJVO1IDwLgbi8dht9ZE-bma36gP-CTdI3ahIaMONR6gaSv5e--hwW9FjRgnaPrN7MeWebEb8hvg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104395714"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104395714/Intravitreal_growth_factors_in_proliferative_diabetic_retinopathy_correlation_with_neovascular_activity_and_glycaemic_management"><img alt="Research paper thumbnail of Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management" class="work-thumbnail" src="https://attachments.academia-assets.com/104137626/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104395714/Intravitreal_growth_factors_in_proliferative_diabetic_retinopathy_correlation_with_neovascular_activity_and_glycaemic_management">Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management</a></div><div class="wp-workCard_item"><span>British Journal of Ophthalmology</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim-Many growth factors are implicated in proliferative diabetic retinopathy (PDR). It was decide...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim-Many growth factors are implicated in proliferative diabetic retinopathy (PDR). It was decided to test the hypothesis that no one factor is predominant but that a regular profile of levels of diVerent growth factors might be operating, and that the profile might diVer according to whether or not insulin therapy was part of the patient's glycaemic management. The levels of several growth factors in vitrectomy samples were therefore determined from diabetic patients with tractional, non-haemorrhagic sequelae of PDR and these levels were correlated with (a) each other (growth factor profile), (b) neovascular activity, and (c) the method of glycaemic management (insulin treated (IT) or non-insulin treated (NIT)). Methods-72 samples of vitreous were obtained from either diabetic patients with PDR (n = 51) or non-diabetic (control) patients (n = 21). Levels of bFGF, IGF-I, EGF, and insulin were determined by radioimmunoassay; levels of TGF-2 by ELISA; and levels of IGF-I binding protein by western ligand blotting. The data were analysed using appropriate statistics. Results-There was no regular growth factor profile. bFGF levels were significantly greater in vitreous from NIT patients compared with IT patients and controls. The highest levels of bFGF were found in NIT patients with actively vascularised membranes. TGF-2 levels were significantly greater in vitreous from IT patients compared with NIT patients and controls The highest levels of TGF-2 were found in IT patients with actively vascularised membranes. IGF-I levels were significantly greater in diabetics (irrespective of insulin treatment) than non-diabetics and the highest levels of IGF-I were found in IT patients with actively vascularised membranes. A 34 kDa IGFBP was the predominant IGFBP identified in vitreous and was found to be elevated in diabetics patients. Conclusion-In PDR there is a correlation between intravitreal growth factor levels and both disease state (whether active or fibrotic) and method of glycaemic management.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e506de911be3e6396e00244af94ed88" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104137626,"asset_id":104395714,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104137626/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104395714"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104395714"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104395714; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100641919"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100641919/Effect_of_Hypoxia_on_the_Proliferation_of_Microvascular_Cells_in_Vitro"><img alt="Research paper thumbnail of Effect of 'Hypoxia' on the Proliferation of Microvascular Cells in Vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/101406682/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100641919/Effect_of_Hypoxia_on_the_Proliferation_of_Microvascular_Cells_in_Vitro">Effect of 'Hypoxia' on the Proliferation of Microvascular Cells in Vitro</a></div><div class="wp-workCard_item"><span>Experimental Eye Research</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This study investigated the effect of hypoxia on the proliferation of microvascular endothelial c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This study investigated the effect of hypoxia on the proliferation of microvascular endothelial cells in the brain. Endothelial cells derived from microvessels of Mongolian gerbil brain and control cells (3T3) were incubated for 7 days under various hypoxic and normoxic conditions at 37&deg;C. The pro liferation of endothelial cells was inhibited by severe hypoxia, but stimulated by moderate hypoxia. No significant effect of hypoxia on the proliferation of control cells was observed. Endothelial cell-con ditioned medium cultured under moderate hypoxia did not affect the growth of endothelial cells. The stimulatory effect of moderate hypoxia on the proliferation of cultured endothelial cells is due to an inherent property of brain endothelial cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e50ee5d60706078584bffcea768cd890" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101406682,"asset_id":100641919,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101406682/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100641919"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100641919"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100641919; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100641918"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100641918/Effect_of_varying_oxygen_concentrations_on_the_proliferation_of_retinal_microvascular_cells_in_vitro"><img alt="Research paper thumbnail of Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/101406683/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100641918/Effect_of_varying_oxygen_concentrations_on_the_proliferation_of_retinal_microvascular_cells_in_vitro">Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitro</a></div><div class="wp-workCard_item"><span>Experimental Eye Research</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Microvascular fragments and pure cultures of either retinal microvascular endothelial cells, reti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Microvascular fragments and pure cultures of either retinal microvascular endothelial cells, retinal pericytes or Tenon's capsule fibroblasts were grown on a gas permeable substrate while exposed to varying oxygen concentrations (5, 10, 20,40 and 9 5 y0 oxygen). For all three cell types cell proliferation was greatest under the lowest oxygen concentration and decreased as the oxygen concentration increased. The decrease in the proliferative ability of cells exposed to the higher oxygen concentrations could be reversed if the cells were returned to a normoxic environment. Endothelial cells were the most sensitive to changes in oxygen tensions showing a proliferative response after 24 hr exposure as opposed to 48 hr for pericytes and fibroblasts. These results suggest a direct mechanism by which the intra-vitreal and intra-retinal oxygen tension may influence both the development of preretinal new vessels (in response to retinal ischaemia) and also the regression of neovascularization following scatter photocoagulation or vitrectomy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da9413d10da10ad51b0bb4880c02aa69" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101406683,"asset_id":100641918,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101406683/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100641918"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100641918"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100641918; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100641915"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100641915/Oxygen_modulates_production_of_bFGF_and_TGF_%CE%B2_by_retinal_cells_in_vitro"><img alt="Research paper thumbnail of Oxygen modulates production of bFGF and TGF-尾 by retinal cells in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/101406667/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100641915/Oxygen_modulates_production_of_bFGF_and_TGF_%CE%B2_by_retinal_cells_in_vitro">Oxygen modulates production of bFGF and TGF-尾 by retinal cells in vitro</a></div><div class="wp-workCard_item"><span>Experimental Eye Research</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vasoproliferative retinopathies result from retinal capillary non-perfusion and consequent inner ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vasoproliferative retinopathies result from retinal capillary non-perfusion and consequent inner retinal hypoxia. However, it is not known whether oxygen mediates vasoproliferation directly (at the nuclear level) or indirectly by regulating the production of growth factors. We have investigated the effect of oxygen on the production of basic fibroblast growth factor and transforming-growth-factor-beta by a variety of retinal cell types in culture. Confluent cultures were maintained for 48 hr under varying oxygen tensions ranging from 135 to 18 mmHg. A reduction in basic fibroblast growth factor levels was observed in the cell lysates and extracellular matrix from retinal microvascular endothelial cell, retinal microvascular pericyte and retinal pigment epithelial cell cultures when the oxygen tension of the medium was reduced from 135 to 18 mmHg. Levels of basic fibroblast growth factor in conditioned media from microvascular endothelial and retinal pigment epithelial cell cultures also decreased when the oxygen tension of the medium was reduced from 135 to 18 mmHg. Total transforming-growth-factorbeta (and specifically isoforms 1 and 2) in the conditioned media from all three cell types was similarly modulated by oxygen i.e. it decreased as the oxygen tension of the medium was reduced from 135 to 18 mmHg. In contrast, the steady state messenger RNA levels for both basic fibroblast growth factor and transforming-growth-factor-betal genes in RPE ceils increased significantly when the oxygen tension of the medium was reduced from 135 to 18 mmHg. These results support the putative role of oxygen in influencing the balance of growth factors during the development of preretinal new vessels.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efcf4c569f4bcfd385b43eb7d6663cac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101406667,"asset_id":100641915,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101406667/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100641915"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100641915"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100641915; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93345372"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/93345372/The_effect_of_scatter_laser_photocoagulation_on_intravitreal_levels_of_growth_factors_in_the_miniature_pig"><img alt="Research paper thumbnail of The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/93345372/The_effect_of_scatter_laser_photocoagulation_on_intravitreal_levels_of_growth_factors_in_the_miniature_pig">The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig</a></div><div class="wp-workCard_item"><span>Current Eye Research</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To characterise changes in intravitreal growth factor profiles following retinal photocoagulation...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To characterise changes in intravitreal growth factor profiles following retinal photocoagulation in the miniature pig. Miniature pig eyes underwent scatter photocoagulation by either diode infrared or emerald green laser. Animals were sacrificed at various times (up to 42 days) post-laser. The eyes were than removed and vitreous samples analysed for basic fibroblast growth factor, insulin-like growth factor-I and epidermal growth factor by radioimmunoassay, transforming growth factor-beta 2 by ELISA and insulin-like growth factor binding proteins using Western ligand blotting. Vitreous transforming growth factor-beta 2 levels were decreased at 1 h post diode laser and at 4 and 7 days post emerald laser but returned to normal by 21 and 42 days respectively. Vitreous insulin-like growth factor-I levels increased at 4 and 7 days post diode and emerald laser respectively but returned to normal by 21 days. Insulin-like growth factor Western ligand blotting demonstrated that a 34 kDa insulin-like growth factor binding protein was predominant in the pig vitreous; the levels of this binding protein followed an identical trend to those observed for insulin-like growth factor-I. No changes in vitreous levels of either basic fibroblast growth factor or epidermal growth factor were observed following laser treatment. Our results demonstrate a significant shift in the balance of intravitreal growth factors following retinal laser photocoagulation. Such changes may be pertinent to the regression of preretinal new vessels after laser photocoagulation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93345372"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93345372"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93345372; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=93345372]").text(description); $(".js-view-count[data-work-id=93345372]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 93345372; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='93345372']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=93345372]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":93345372,"title":"The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig","internal_url":"https://www.academia.edu/93345372/The_effect_of_scatter_laser_photocoagulation_on_intravitreal_levels_of_growth_factors_in_the_miniature_pig","owner_id":173435165,"coauthors_can_edit":true,"owner":{"id":173435165,"first_name":"Patrick","middle_initials":null,"last_name":"Moriarty","page_name":"PatrickMoriarty13","domain_name":"independent","created_at":"2020-10-07T07:17:57.445-07:00","display_name":"Patrick Moriarty","url":"https://independent.academia.edu/PatrickMoriarty13"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="86692963"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/86692963/Protein_Kinase_C_Isoenzyme_Expression_in_Retinal_Cells"><img alt="Research paper thumbnail of Protein Kinase C Isoenzyme Expression in Retinal Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/86692963/Protein_Kinase_C_Isoenzyme_Expression_in_Retinal_Cells">Protein Kinase C Isoenzyme Expression in Retinal Cells</a></div><div class="wp-workCard_item"><span>Ophthalmic Research</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Protein kinase C (PKC) is involved in both the physiological and pathophysiological processes in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Protein kinase C (PKC) is involved in both the physiological and pathophysiological processes in the retina and plays an important role in signal transduction. The aim of this study was to determine the PKC isoenzyme profile in three retinal cell types in culture, namely RPE cells, pericytes and retinal microvascular endothelial cells. Confluent cultures were lysed and isoenzyme expression detected by Western blotting. PKC isoenzymes 伪, 尾2 and 未 were observed for all three cell types while 尾1 was specific for RPE cells. 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