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What Are the Cellular and Molecular Consequences? | Phenylketonuria (pku)
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Inhibition</strong>: High levels of phenylalanine can inhibit other enzymes involved in amino acid metabolism, leading to a disturbance in the metabolic balance.<br>2. <strong>Oxidative Stress</strong>: Excess phenylalanine and its byproducts generate free radicals, causing oxidative damage to cellular components like lipids, proteins, and DNA.<br>3. <strong>Neurotoxicity</strong>: Phenylalanine can cross the blood-brain barrier and affect brain cells, leading to impaired synaptic transmission and neuronal damage.</div></div> </div> <hr /> <h3 class="rq-heading">Frequently asked queries:</h3> <div class="qa-container"> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-is-phenylketonuria-pku" title="What is Phenylketonuria (PKU)?">What is Phenylketonuria (PKU)?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-causes-pku-at-the-cellular-level" title="What Causes PKU at the Cellular Level?">What Causes PKU at the Cellular 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transport"> Nuclear-cytoplasmic transport </a></li> <li> <a href="https://cellbiology.blog/archive/tag/nucleocytoplasmic-shuttling/" title="nucleocytoplasmic shuttling"> nucleocytoplasmic shuttling </a></li> <li> <a href="https://cellbiology.blog/archive/tag/nucleoporins/" title="nucleoporins"> nucleoporins </a></li> <li> <a href="https://cellbiology.blog/archive/tag/parp/" title="PARP"> PARP </a></li> <li> <a href="https://cellbiology.blog/archive/tag/photothermal-therapy/" title="photothermal therapy"> photothermal therapy </a></li> <li> <a href="https://cellbiology.blog/archive/tag/programmed-cell-death/" title="Programmed cell death"> Programmed cell death </a></li> <li> <a href="https://cellbiology.blog/archive/tag/protein-synthesis-regulation/" title="protein synthesis regulation"> protein synthesis regulation </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rangtp/" title="RanGTP"> RanGTP </a></li> <li> <a href="https://cellbiology.blog/archive/tag/reinitiation/" title="reinitiation"> reinitiation </a></li> <li> <a href="https://cellbiology.blog/archive/tag/ribosome-scanning/" title="ribosome scanning"> ribosome scanning </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rna-export/" title="RNA export"> RNA export </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rna-export-mechanisms/" title="RNA export mechanisms"> RNA export mechanisms </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rna-binding-proteins/" title="RNA-binding proteins"> RNA-binding proteins </a></li> <li> <a href="https://cellbiology.blog/archive/tag/targeted-drug-delivery/" title="targeted drug delivery"> targeted drug delivery </a></li> <li> <a href="https://cellbiology.blog/archive/tag/translational-control/" title="Translational control"> Translational control </a></li> <li> <a href="https://cellbiology.blog/archive/tag/upstream-open-reading-frames-uorfs/" title="upstream open reading frames (uORFs)"> upstream open reading frames (uORFs) 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