Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge (SPCKB-PS-011938) by ProteinSimple, Part of Bio-Techne

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class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup 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data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge </h1> <h2 class="font-weight-normal h4"> ProteinSimple, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">SPCKB-PS-011938</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div class="col-auto d-flex align-self-center"> <div> <a href="#product-documents" class="datasheet_link product-datasheets" rel="nofollow">Product Datasheet / COA</a> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Simple Plex Human Phospho-Tau (T217) ALZpath assay kit for use on the Ella instrument. Contains Cartridge, Sample Diluent SD06, and Wash Buffer. </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-proteinsimple.svg" alt="ProteinSimple, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> </div> <div id="product_alerts_wrapper"><article class="product-data-wrapper"> </article> </div> </div> <div class="row border-top mb-2" id="images_atc_orderinfo_wrapper"><div class="col-xl-9 mt-2" id="image_atc_keydetails_wrapper"><div class="row" id="image_atc_wrapper"><div class="col-xl-4 order-xl-first" id="image_wrapper"><article class="product-data-wrapper"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="proteinsimple"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202474915.png" alt="Simple Plex ALZpath P-Tau 217 Assay Standard Curve" title="Human Phospho-Tau 217 ALZpath Assay Standard Curve" data-caption="Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Human Phospho-Tau 217 ALZpath Assay. Assay range is 0.32 to 1,200 pg/mL." data-badges="" data-application="N/A" width="250" height="250" fetchpriority=high as=image class="search_result_thumbnail_image" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(5)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202475028.png" data-alt="Simple Plex P-Tau 217 ALZpath Assay Functional LLOQ and LOD" title="Human Phospho-Tau 217 ALZpath Assay Endogenous Sample Values" data-caption="EDTA plasma and CSF samples from apparently healthy individuals were tested with the Simple Plex Human Phospho-Tau 217 ALZpath Assay. With this small cohort of samples, 100% detectability of CSF samples was observed and 22% of EDTA plasma samples were detectable above the assays functional limit of detection (LOD) of 0.09 pg/mL. Functional LOD and functional LLOQ are calculated as the LOD and LLOQ of the assay multiplied by the minimum required dilution (MRD) for the sample type." data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11112024104634.jpg" data-alt="Phosphorylated Tau 217 Levels In Alzheimer’s Disease Samples" title="Plasma and CSF p-Tau 217 Levels in Alzheimer’s Disease Patients" data-caption="Plasma and CSF p-tau 217 levels of healthy control donors and clinically diagnosed Alzheimer’s disease patients were measured using the Simple Plex Human Phospho-Tau 217 ALZpath Assay. ATN positive patients (ATN+) showed elevated plasma and CSF phosphorylated tau 217 levels when compared to both healthy controls as well as ATN negative patients (ATN-). Significant difference in CSF phosphorylated tau 217 levels was also found upon comparison of ATN+ and Amyloid positive (A+) patient groups." data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202475112.jpg" data-alt="Ella Automated ELISA And Simple Plex ALZpath P-Tau 217 Assay" title="Ella Automated ELISA and Simple Plex Phosphorylated Tau 217 ALZpath Assay" data-caption="" data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-1511202475554..png" data-alt="Simple Plex ALZpath P-Tau 217 Assay Linearity" title="Human Phospho-Tau 217 ALZpath Assay Linearity" data-caption="Samples containing and/or spiked with high concentrations of recombinant human phospho-tau 217 were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay." data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> </div> </div> </article> </div> <div class="col-xl-8" id="atc_wrapper"><article class="product-data-wrapper position-relative align-vertical"> <div id="order_detail_wrapper" class="order_detail_wrapper"> <h3>Customize Your Simple Plex Cartridge</h3> <p>Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.</p> <hr class="a___border-dashed my-4"> <div class="text-right mb-2"> <a class="btn btn-primary text-white" href="/resources/simple-plex-panel-builder"> Build My Cartridge </a> </div> </div> </article> </div> </div> <div class="row datapoint_list border-top" id="key_details_wrapper"><div class="col-xl-12 mt-2" id="key_details_col_wrapper"></div> </div> </div> <div class="col-xl-3 mt-2" id="orderinfo_guarantee_wrapper"><div id="order_information_wrapper"> <div id="product_shipping_block_wrapper" data-brand="proteinsimple" data-shipping="" data-source="ep-data" data-sub_category_id="136"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"><span class="sr-only">Loading...</span></div> </div> </div> <div id="product_ads_wrapper"><article class="product-data-wrapper"> </article> </div> </div> </div> <div class="datapoint_list" id="key_details"><h3>Key Product Details</h3><table class="tablesaw tablesaw-stack table" id="key_details_table_wrapper"><tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Assay Length: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 90 minutes </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Sample Type & Volume Required Per Well: </td> <td class="product-data-value py-2 align-top w-75 text-break"> Serum (25 uL), EDTA Plasma (25 uL), Heparin Plasma (25 uL), Cerebrospinal Fluid (25 uL) </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Sensitivity: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 0.09 pg/mL </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Assay Range: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 0.32 - 1,200 pg/mL (Serum, EDTA Plasma, Heparin Plasma, Cerebrospinal Fluid) </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge Summary: </td> <td class="product-data-value py-2 align-top w-75 text-break"> Simple Plex assay for the detection of human phosphorylated tau 217 (p-Tau 217) in serum, plasma (EDTA/Heparin), <span>and cerebrospinal fluid (CSF) in Sample Diluent SD06.</span> </td> </tr> </table> </div> <div class="mt-2" id="prod_key_details_footnote"><p>*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix.  Serial dilution may be necessary to achieve some of the final sample volumes represented.</p> </div> <div id="view_technical_detail_links"><div class="text-center"> <a id="view_technical" href="#about-data-tab-tab">View Full Technical Details for Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge</a> </div> </div> </div> <div class="tab-content rounded-bottom shadow border-0 mb-3"><div id="about-data-tab-tab"></div> <ul class="nav nav-tabs nav-fill " id="productTab" role="tablist"> <li class="nav-item"> <a class="nav-link active" id="technical-data-tab-tab" href="#technical-data-tab" data-toggle="tab" role="tab" aria-controls="region-5791588863627" aria-selected="true" >Technical Data</a> </li> <li class="nav-item"> <a class="nav-link" id="citations-tab-tab" href="#citations-tab" data-toggle="tab" role="tab" aria-controls="region-8571587488941" aria-selected="false" >Citations</a> </li> </ul> <div class="tab-content rounded-bottom border-left border-right border-bottom mb-3" id="ProductTabContent"><div class="tab-pane fade show active mx-4" id="technical-data-tab" data-tab-label="Technical Data" role="tabpanel" aria-labelledby="technical-data-tab-tab"><div class="product_details_anchors"><div class="product-pages-anchors nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"><li id="product-specifications_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor active" href="#product-specifications" id="product-specifications_li" >Product Specifications</a> </li> <li id="precision_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#precision" id="precision_li" >Precision</a> </li> <li id="recovery_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#recovery" id="recovery_li" >Recovery</a> </li> <li id="linearity_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#linearity" id="linearity_li" >Linearity</a> </li> <li id="scientific-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#scientific-data" id="scientific-data_li" >Scientific Data</a> </li> <li id="preparation-and-storage_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#preparation-and-storage" id="preparation-and-storage_li" >Preparation and Storage</a> </li> <li id="background_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#background" id="background_li" >Background</a> </li> <li id="product-documents_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 product-documents datasheet_static_link" href="#product-documents" id="product-documents_li" >Product Datasheets</a> </li> </div> <div id="product-specifications" class="nav-link px-0" data-anchor-label="Product Specifications"><div id="product_specifications_section"><h3>Product Specifications for Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge</h3><table class="table-bordered table" id="table_wrapper"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Assay Type</td> <td class="product-data-value p-3 px-4 text-break"> Automated sandwich ELISA </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Format</td> <td class="product-data-value p-3 px-4 text-break"> Microfluidic cartridge containing three Glass Nano Reactors (GNR) </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Reactivity</td> <td class="product-data-value p-3 px-4 text-break"> Human </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Specificity</td> <td class="product-data-value p-3 px-4 text-break"> Natural and recombinant human phospho-Tau. </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Cross-reactivity</td> <td class="product-data-value p-3 px-4 text-break"> < 0.5% cross-reactivity observed with available related molecules. < 50% cross-species reactivity observed with species tested. </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Interference</td> <td class="product-data-value p-3 px-4 text-break"> No significant interference observed with available related molecules. </td> </tr> </table> </div> </div> <div id="precision" class="nav-link px-0" data-anchor-label="Precision"><div id="precision_wrapper"><h3>Precision </h3> <p><div><strong>Intra-Assay Precision (Precision within an assay)</strong> Multiple replicates of each p-Tau 217 control were tested in one assay</div><div><strong>Inter-Assay Precision (Precision between assays)</strong> Replicates of each p-Tau 217 control were tested in multiple assays performed by at least three technicians using two lots of reagent</div></p> <p class="precision_title"><strong>Serum, EDTA Plasma, Heparin Plasma, Cerebrospinal Fluid</strong></p> <table class="ds_table_html precision_table table-bordered"> <thead> <tr> <th class="p1 p-3 w-25"></th> <th colspan="2" class="w-25 p-3">Intra-Assay Precision</th> <th colspan="2" class="p-3 w-25">Inter-Assay Precision</th> </tr> </thead> <tbody> <tr> <td class="p-3"><strong>Sample</strong></td> <td class="p-3">1</td> <td class="p-3">2</td> <td class="p-3">1</td> <td class="p-3">2</td> </tr> <tr> <td class="p-3"><strong>n</strong></td> <td class="p-3">16</td> <td class="p-3">16</td> <td class="p-3">66</td> <td class="p-3">66</td> </tr> <tr> <td class="p-3"><strong>Mean (pg/mL)</strong></td> <td class="p-3">8.3</td> <td class="p-3">444</td> <td class="p-3">8.7</td> <td class="p-3">422</td> </tr> <tr> <td class="p-3"><strong>Standard Deviation</strong></td> <td class="p-3">0.36</td> <td class="p-3">19.9</td> <td class="p-3">0.91</td> <td class="p-3">38</td> </tr> <tr> <td class="p-3"><strong>CV%</strong></td> <td class="p-3">4.3</td> <td class="p-3">4.5</td> <td class="p-3">10.5</td> <td class="p-3">8.9</td> </tr> </tbody> </table> </div> </div> <div id="recovery" class="nav-link px-0" data-anchor-label="Recovery"><div id="elisa_recovery"><h3>Recovery</h3> <div> <p>Recovery for the Human Phospho-Tau 217 ALZpath assays was evaluated at three different spiked concentrations of p-Tau 217 protein.<p> </div> <table class="ds_table_html recovery_table table-bordered"> <thead> <th class="p-3">Sample Type</th> <th class="p-3">Average % Recovery</th> <th class="p-3">Range %</th> </thead> <tr> <td class="p-3">Cerebrospinal Fluid (n=4)</td> <td class="p-3">138</td> <td class="p-3">131-142</td> </tr> <tr> <td class="p-3">EDTA Plasma (n=4)</td> <td class="p-3">97</td> <td class="p-3">83-109</td> </tr> <tr> <td class="p-3">Heparin Plasma (n=4)</td> <td class="p-3">92</td> <td class="p-3">82-98</td> </tr> <tr> <td class="p-3">Serum (n=4)</td> <td class="p-3">92</td> <td class="p-3">87-96</td> </tr> </table> </div> </div> <div id="linearity" class="nav-link px-0" data-anchor-label="Linearity"><div id="linerarity_wrapper"><h3>Linearity</h3><article class="product-data-wrapper"> Samples containing and/or spiked with high concentrations of recombinant human phospho-tau 217 were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay. </article> <div class="image-basic"> <img src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-1511202475554..png" alt="Human Phospho-Tau 217 ALZpath Assay Linearity" title="Human Phospho-Tau 217 ALZpath Assay Linearity" /> </div> </div> </div> <div id="scientific-data" class="nav-link px-0" data-anchor-label="Scientific Data"><table class="product-data-wrapper tablesaw tablesaw-stack table" id="data_image_table_wrapper"><h3>Scientific Data Examples for Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge</h3><article class="product-data-wrapper"> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202474915.png" data-srcset="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202474915.png" alt="Simple Plex ALZpath P-Tau 217 Assay Standard Curve" title="Human Phospho-Tau 217 ALZpath Assay Standard Curve" data-caption="Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Human Phospho-Tau 217 ALZpath Assay. Assay range is 0.32 to 1,200 pg/mL." data-badges="" data-application="N/A" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Human Phospho-Tau 217 ALZpath Assay Standard Curve</strong> Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Human Phospho-Tau 217 ALZpath Assay. Assay range is 0.32 to 1,200 pg/mL. </p> </td> </tr> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202475028.png" data-srcset="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-2410202475028.png" alt="Simple Plex P-Tau 217 ALZpath Assay Functional LLOQ and LOD" title="Human Phospho-Tau 217 ALZpath Assay Endogenous Sample Values" data-caption="EDTA plasma and CSF samples from apparently healthy individuals were tested with the Simple Plex Human Phospho-Tau 217 ALZpath Assay. With this small cohort of samples, 100% detectability of CSF samples was observed and 22% of EDTA plasma samples were detectable above the assays functional limit of detection (LOD) of 0.09 pg/mL. Functional LOD and functional LLOQ are calculated as the LOD and LLOQ of the assay multiplied by the minimum required dilution (MRD) for the sample type." data-badges="" data-application="N/A" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Human Phospho-Tau 217 ALZpath Assay Endogenous Sample Values</strong> EDTA plasma and CSF samples from apparently healthy individuals were tested with the Simple Plex Human Phospho-Tau 217 ALZpath Assay. With this small cohort of samples, 100% detectability of CSF samples was observed and 22% of EDTA plasma samples were detectable above the assays functional limit of detection (LOD) of 0.09 pg/mL. Functional LOD and functional LLOQ are calculated as the LOD and LLOQ of the assay multiplied by the minimum required dilution (MRD) for the sample type. </p> </td> </tr> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11112024104634.jpg" data-srcset="https://resources.bio-techne.com/images/products/spckb-ps-011938_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11112024104634.jpg" alt="Phosphorylated Tau 217 Levels In Alzheimer’s Disease Samples" title="Plasma and CSF p-Tau 217 Levels in Alzheimer’s Disease Patients" data-caption="Plasma and CSF p-tau 217 levels of healthy control donors and clinically diagnosed Alzheimer’s disease patients were measured using the Simple Plex Human Phospho-Tau 217 ALZpath Assay. ATN positive patients (ATN+) showed elevated plasma and CSF phosphorylated tau 217 levels when compared to both healthy controls as well as ATN negative patients (ATN-). Significant difference in CSF phosphorylated tau 217 levels was also found upon comparison of ATN+ and Amyloid positive (A+) patient groups." data-badges="" data-application="N/A" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Plasma and CSF p-Tau 217 Levels in Alzheimer’s Disease Patients</strong> Plasma and CSF p-tau 217 levels of healthy control donors and clinically diagnosed Alzheimer’s disease patients were measured using the Simple Plex Human Phospho-Tau 217 ALZpath Assay. ATN positive patients (ATN+) showed elevated plasma and CSF phosphorylated tau 217 levels when compared to both healthy controls as well as ATN negative patients (ATN-). Significant difference in CSF phosphorylated tau 217 levels was also found upon comparison of ATN+ and Amyloid positive (A+) patient groups. </p> </td> </tr> </article> </table> </div> <div id="preparation-and-storage" class="nav-link px-0" data-anchor-label="Preparation and Storage"><div id="elisa_preparation_storage"><h3>Preparation and Storage</h3><table class="table-bordered table" id="elisa_preparation_storage_table"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Stability & Storage</td> <td class="product-data-value p-3 px-4 text-break"> Store the unopened product at 2 - 8 °C. Do not use past expiration date. </td> </tr> </table> </div> </div> <div id="background" class="nav-link px-0" data-anchor-label="Background"><div id="background_information_wrapper"> <div id="background_information_wrapper"> <h3> Background: Tau </h3> <article class="product-data-wrapper"> Tau protein serves as a bridge from microtubules to the plasma membrane to facilitate formation and stabilization of the microtubule network. Tau in PNS neurons is 758 amino acids (aa) in length and 110 kDa in size, but multiple isoforms exist, ranging from 316 to 776 aa in length. Various deletions occur within the first 500 aa, with some isoforms also showing an absence of the second Tau repeat. </article> <table class="tablesaw tablesaw-stack table-bordered" id="prep_storage_wrapper"> <thead style="display:none;"> <th>Item</th> <th>Value</th> </thead> <tbody> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right">Long Name</td> <td class="product-data-value w-75 p-3 px-4"> Microtubule-Associated Protein Tau </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right">Entrez Gene IDs</td> <td class="product-data-value w-75 p-3 px-4"> 4137 (Human); 17762 (Mouse); 29477 (Rat) </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right">Alternate Names</td> <td class="product-data-value w-75 p-3 px-4"> DDPAC, FLJ31424, FTDP-17, G protein beta1/gamma2 subunit-interacting factor 1, MAPT, MGC138549, MSTD, MSTDMAPTL, MTBT1, MTBT1Neurofibrillary tangle protein, MTBT2, Neurofibrillary tangle protein, PHF-tau, PPND, TAUPaired helical filament-tau, Tau, microtubule-associated protein tau </td> </tr> </tbody> </table> </div> </div> </div> <div id="product-datasheets-anchor" class="nav-link static-anchor p-0" data-anchor-label="Product Datasheets"></div> </div> </div> <div class="tab-pane fade mx-4 py-4" id="citations-tab" data-tab-label="Citations" role="tabpanel" aria-labelledby="citations-tab-tab"><div class="product_details_anchors mb-2"> <div class="nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#citations"> Citations </a> </li> </div> </div> <div id="citations"> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="SPCKB-PS-011938"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> </div> </div> </div> </div> <div id="compatible-instruments-wrapper"><div id="compatible-intruments-anchor"></div> <div id="compatible-instruments" class="top_region px-0"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Compatible Instruments</h3> </div> <div id="carouselCompatiableInstrument" class="carousel slide" data-ride="carousel"> <div class="carousel-inner"> <div class="carousel-item active"> <div class="row w-75 m-auto"> <div class="col-md-4"> <img src="https://resources.rndsystems.com/images/datasheets/Ella_System_600100_ELISA_2642.png" alt="Ella Automated Immunoassay System" title="Ella Automated Immunoassay System" loading="lazy"/> </div> <div class="col-md-8"> <div class="carousel-caption position-initial"> <h4>Ella - Automated Immunoassay Platform | ProteinSimple </h4> <article>Ella from ProteinSimple, a Bio-Techne brand. Get single or multiplex immunoassay results in less than 90 minutes that are consistent and highly reproducible. </article> <div class="mt-3"> <a href="/p/simple-plex/ella-automated-immunoassay-system_600-100" class="btn btn-primary"> Learn More </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="product-documents"> <div id="datasheet-accordion" class="accordion border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Product Documents for Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge</h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#datasheet-accordion"> <div class="card-body"> 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Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge (SPCKB-PS-011938) by ProteinSimple, Part of Bio-Techne