Publikationen - Chemoinformatics and Protein Modelling

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Identification of the TRPA1 cannabinoid-binding site. <i>Pharmacological Research</i> 2024; 209. <a href="https://doi.org/10.1016/j.phrs.2024.107444" target="_top">doi.org/10.1016/j.phrs.2024.107444</a> </p> <p class="text-justify">Czech C, Lang T, Graßl A, Steuer A, Di Pizio A, Behrens M, Lang R. Identification of mozambioside roasting products and their bitter taste receptor activation. <i>Food Chemistry </i>2024, 446, 138884. <a href="https://doi.org/10.1016/j.foodchem.2024.138884" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.foodchem.2024.138884</a></p> <p class="text-justify">Di Pizio A*. A bitter taste receptor activated in a surprising way.<i> Nature </i>(News and Views) 2024. <a href="https://doi.org/10.1038/d41586-024-00712-6" target="_top">doi: 10.1038/d41586-024-00712-6</a></p> <p>Dos Santos Natividade R, Dumitru AC, Nicoli A, Strebl M, Sutherland DM, Welsh OL, Ghulam M, Stehle T, Dermody TS, Di Pizio A*, Koehler M*, Alsteens D*. Viral capsid structural assembly governs the reovirus binding interface to NgR1. <i>Nanoscale Horizons</i> 2024; 9, 1925. <a href="https://pubs.rsc.org/en/content/articlelanding/2024/nh/d4nh00315b" target="_top">doi.org/10.1039/d4nh00315b</a></p> <p>Kogut-Günthel MM, Zara Z, Nicoli A, Steuer A, Lopez-Balastegui M, Selent J, Karanth S, Koehler M, Ciancetta A, Abiko LA, Hagn F, Di Pizio A*. The path to the G protein-coupled receptor structural landscape: Major milestones and future directions. British Journal of Oharmacology 2024, 1-24.  <a href="https://doi.org/10.1111/bph.17314" target="_top">doi.org/10.1111/bph.17314</a></p> <p>Lopez-Balastegui M, Stepniewski TM, Koguut-Günthel MM, Di Pizio A, Rosenkilde MM, Mao J, Selent J. Relevance of G protein-coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation. <i>British Journal of Pharmacology</i> 2024, 1-14. <a href="https://doi.org/10.1111/bph.16495" target="_top">doi: 10.1111/bph.16495</a> </p> <p>Musiol E, Fromme T,Hau J, Di Pizio A, Klingenspor M. Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1. <i>ActaPhysiol </i>2024;00:e14209. <a href="https://onlinelibrary.wiley.com/doi/10.1111/apha.14209" target="_top">doi:10.1111/apha.14209</a></p> <p class="text-justify">Schaefer S, Ziegler F, Lang T, Steuer A, Di Pizio A, Behrens M. sweet-bound chemoreception of bitter bile acids and peptides is mediated by the same subset of bitter taste receptors. <i>Cellular and Molecular Life Sciences</i> 2024, 81 (1), 1-13. <a href="https://doi.org/10.1007/s00018-024-05202-6" target="_top">doi: 10.1007/s00018-024-05202-6</a></p> <p>Scharf MM*, Humphrys L, Berndt L, Di Pizio A, Lehmann J, Liebscher I, Nicoli A, Niv M, Peri L, Schihada H, Schulte G. The dark sides of the GPCR tree - research progress on understudied GPCRs. <i>British Journal of Pharmacology </i>2024. <a href="https://doi.org/10.1111/bph.16325" target="_top">doi: 10.1111/bph.16325</a></p> <p>Srivastava P, Steuer A, Ferri F, Nicoli A, Schultz K, Bej S, Di Pizio A*, Wolkenhauer O*. Bitter peptide prediction using graph neural networks. <i>Journal of Cheminformatics</i> 2024; 16, 111. <a href="https://doi.org/10.1186/s13321-024-00909-x" target="_top">doi.org/10.1186/s13321-024-00909-x</a></p> <p> </p> <p><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6797" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6798" class="frame frame-type-textmedia frame-layout-0"> <h2> 2023 </h2> <p class="text-justify">Di Pizio A*, Bermudez M, De Graaf C, Jockers R*. Editorial: Peptide-binding GPCRs coming of age. <i>Front. Endocrinol. - Cellular Endocrinology</i> 2023. <a href="https://doi.org/10.3389/fendo.2023.1189508" target="_top">doi: 10.3389/fendo.2023.1189508</a></p> <p class="text-justify">Lang T, Di Pizio A, Risso D, Drayna D, Behrens M*. Activation Profile of Tas2r2, The 26th Human Bitter Taste Receptor. <i>Molecular Nutrition & Food Research </i>2023, 2200775. <a href="https://doi.org/10.1002/mnfr.202200775" target="_top"><i>doi: 10.1002/mnfr.202200775</i></a></p> <p class="text-justify">Morales P, Scharf MM, Johnson CP, Di Pizio A*, Hilger D*. Editorial: New approaches for the discovery of GPCR ligands. <i>Front Endocrinol </i>2023, 14, 1272700. <a href="https://doi.org/10.3389/fendo.2023.1272700" target="_top">doi: 10.3389/fendo.2023.1272700</a></p> <p class="text-justify">Nicoli A, Haag F, Marcinek P, He R, Kreißl J, Stein J, Marchetto A, Dunkel A, Hofmann T, Krautwurst D*, Di Pizio A*. Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1, Journal of Chemical Information and Modeling 2023, 63(7), 2014. <a href="https://doi.org/10.1021/acs.jcim.2c00752" target="_top" title="DOI URL">doi: 10.1021/acs.jcim.2c00752</a></p> <p class="text-justify">Nicoli A, Weber V, Bon C, Steuer A, Gustincich S, Gainetdinov RR, Lang R, Espinoza S*, Di Pizio A*. Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists. <i>J Chem Inf Model </i>2023. <a href="https://doi.org/10.1021/acs.jcim.3c00755" target="_top" title="DOI URL">doi: 10.1021/acs.jcim.3c00755</a></p> <p class="text-justify">Tiroch J, Dunkel A, Sterneder S, Teetner S, Behrens M, Di Pizio A, Ley JP, Lieder B, Somoza V*. Human Gingival Fibroblasts as a Novel Cell Model Describing the Association between Bitter Taste Thresholds and Interleukin-6 Release. <i>Journal of Agricultural and Food Chemistry </i>2023. <a href="https://doi.org/10.1021/acs.jafc.2c06979" target="_top" title="DOI URL">doi: 10.1021/acs.jafc.2c06979</a></p> <p class="text-justify">Ziegler F, Steuer A, Di Pizio A, Behrens M*. Physiological Activation of Human and Mouse Bitter Taste Receptors by Bile Acids. <i>Communications Biology </i>2023, 6, 612. <a href="https://doi.org/10.1038/s42003-023-04971-3" target="_top">doi: 10.1038/s42003-023-04971-3</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6799" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6800" class="frame frame-type-textmedia frame-layout-0"> <h2> 2022 </h2> <p class="text-justify">Adler Berke N,<sup> $</sup> Di Pizio A,<sup>$</sup> Vaden TD, Shoval I, Gover O, Waiger D, Solomon G, Sepčić K, Schwartz B*. Critical sites on ostreolysin A responsible for interaction with cytoskeletal proteins. <i>Biomedicines</i> 2022, 10(10), 2442. IF (2020): 4.8. <a href="https://doi.org/10.3390/biomedicines10102442" target="_top">doi: 10.3390/biomedicines10102442</a></p> <p class="text-justify">De León G, Fröhlich E, Di Pizio A, Salar-Behzadi S* Premexotac: Bitterants in silico Screening using Machine Learning for Advancing Pharmaceutical Development. International Journal of Pharmaceutics 2022, 628, 122263. <a href="https://doi.org/10.1016/j.ijpharm.2022.122263" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.ijpharm.2022.122263</a></p> <p class="text-justify">Haag F, Di Pizio A, Krautwurst D*. The key food odorant receptive range of broadly tuned receptor OR2W1. <i>Food Chemistry </i>2022, 375: 131680. IF (2020): 7.5. <a href="https://doi.org/10.1016/j.foodchem.2021.131680" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.foodchem.2021.131680</a></p> <p class="text-justify">León B*, González G, Nicoli A, Rojas A, Di Pizio A, Ramirez-Carvajal L, Jiménez C. Phylogenetic and mutation analysis of the Venezuelan equine encephalitis virus sequence isolated in Costa Rica from a mare with encephalitis. <i>Veterinary Sciences 2022</i>, 9(6): 258. IF (2020): 2.3. <a href="https://doi.org/10.3390/vetsci9060258" target="_top">doi: 10.3390/vetsci9060258</a></p> <p class="text-justify">Nicoli A, Dunkel A, Giorgino T, De Graaf C, Di Pizio A*. Classification Model for the Second Extracellular Loop of Class A GPCRs, <i>Journal of Chemical Information and Modeling</i> 2022, 62(3): 511–522. IF (2020): 5. <a href="https://doi.org/10.1021/acs.jcim.1c01056" target="_top" title="DOI URL">doi: 10.1021/acs.jcim.1c01056</a></p> <p> </p> <p><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6801" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6802" class="frame frame-type-textmedia frame-layout-0"> <h2> 2021 </h2> <p class="text-justify">Agamennone M, Nicoli A, Bayer S, Weber V, Borro L, Gupta S, Fantacuzzi M, Di Pizio A*. Protein-protein interactions at a glance: Protocols for the visualization of biomolecular interactions. <i>Methods in Cell Biology</i> 2021, 166: 271-307, Part of volume: Biomolecular Interactions Part A, ISBN: 978-0-12-823351-1, edited by Arun K. Shukla. <a href="https://doi.org/10.1016/bs.mcb.2021.06.012" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/bs.mcb.2021.06.012</a></p> <p class="text-justify">Bayer S, Mayer AI, Borgonovo G, Morini G, Di Pizio A*, Bassoli A*. Chemoinformatics View on Bitter Taste Receptor Agonists in Food. <i>Journal of Agricultural and Food Chemistry </i>2021, 69(46): 13916–13924. IF (2020): 5.3. <a href="https://doi.org/10.1021/acs.jafc.1c05057" target="_top" title="DOI URL">doi: 10.1021/acs.jafc.1c05057</a></p> <p class="text-justify">Behrens M*, Di Pizio A, Redel U, Meyerhof W*, Korsching SI*. At the root of T2R gene evolution: Recognition profiles of coelacanth and zebrafish bitter receptors. <i>Genome Biology and Evolution </i>2021, 13(1): evaa264. IF (2020): 3.5. <a href="https://doi.org/10.1093/gbe/evaa264" target="_top">doi: 10.1093/gbe/evaa264</a></p> <p class="text-justify">Cecchetto C, Di Pizio A, Genovese F, Calcinoni O, Macchi A, Dunkel A, Ohla K, Spinelli S, Farruggia MC, Joseph PV, Menini A, Cantone E, Dinnella C, Cecchini MP, D’Errico A, Mucignat-Caretta C, Parma V, Dibattista M*. Assessing the extent and timing of chemosensory  impairments during COVID-19 pandemic. <i>Scientific Reports 2021</i>, 11, 17504. IF (2020): 4.0. <a href="https://doi.org/10.1038/s41598-021-96987-0" target="_top">doi: 10.1038/s41598-021-96987-0</a></p> <p class="text-justify">Gerkin RC, …, Di Pizio A, …, Parma V. (GCCR) Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms. <i>Chemical Senses</i> 2021, IF (2020): 3.1.  <a href="https://doi.org/10.1093/chemse/bjaa081" target="_top">doi: 10.1093/chemse/bjaa081</a></p> <p class="text-justify">Ofir-Birin Y, Pilo HBA, Camacho AC, Rudik A, Rivkin A, Revach O-Y, Nir N, Tamin TB, Karam PA, Kiper E, Peleg Y, Nevo R, Solomon A, Havkin-Solomon T, Rojas A, Rotkopf R, Porat Z, Avni D, Schwartz E, Zillinger T, Hartmann G, Di Pizio A, Quashie NB, Dikstein R, Gerlic M, Torrecilhas AC, Levy C, Bowie AG, Regev-Rudzki N*. Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration. <i>Nature Communications 2021</i>, 12, 4851. IF (2020): 14.9. | <a href="https://doi.org/10.1038/s41467-021-24997-7" target="_top">doi: 10.1038/s41467-021-24997-7</a></p> <p class="text-justify">Sterneder S, Stoeger V, Dugulin CA, Liszt KI, Di Pizio A, Korntheuer K, Dunkel A, Eder R, Ley JP, Somoza V*. Astringent Gallic Acid in Red Wine Regulates Mechanisms of Gastric Acid Secretion via Activation of Bitter Taste Sensing Receptor TAS2R4.<i> Journal of Agricultural and Food Chemistry </i>2021, 69(36): 10550–10561. IF (2020): 5.3. <a href="https://doi.org/10.1021/acs.jafc.1c03061" target="_top" title="DOI URL">doi: 10.1021/acs.jafc.1c03061</a></p> <p class="text-justify">Tiroch J, Sterneder S, Di Pizio A, Lieder B, Hoelz K, Holik A, Pignitter M, Behrens M, Somoza M, Ley JP, Somoza V*. Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in Culture. <i>Journal of Agricultural and Food Chemistry </i>2021, 69(45): 13339–13349. IF (2020): 5.3. <a href="https://doi.org/10.1021/acs.jafc.0c07058" target="_top" title="DOI URL">doi: 10.1021/acs.jafc.0c07058</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6803" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6804" class="frame frame-type-textmedia frame-layout-0"> <h2> 2020 </h2> <p class="text-justify">Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, Weinreb C, Joseph PV, Larson ED, Parma V, Albers MW, Barlow LA*, Datta SR*, <strong>Di Pizio A*</strong>. COVID-19 and the chemical senses: supporting players take center stage. <i>Neuron</i> 2020, 107(2): 219-233. IF (2020): 17.2. <a href="https://doi.org/10.1016/j.neuron.2020.06.032" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.neuron.2020.06.032</a></p> <p class="text-justify">Di Pizio A*, Nicoli A. <i>In silico</i> molecular study of tryptophan bitterness. <i>Molecules</i> 2020, 25(20): 4623-4632. IF (2020): 4.4. <a href="https://doi.org/10.3390/molecules25204623" target="_top">doi: 10.3390/molecules25204623</a></p> <p class="text-justify">Di Pizio A, Behr J, Krautwurst D*. Towards the Digitalization of Olfaction, Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2020. ISBN 9780128093245, <a href="https://www.sciencedirect.com/science/article/abs/pii/B9780128093245241473?via%3Dihub" target="_blank" class="ti ti-link-ext" rel="noreferrer">doi: 10.1016/B978-0-12-809324-5.24147-3 </a></p> <p class="text-justify">Dunkel A, Hofmann T, Di Pizio A*. <i>In-silico</i> investigation of bitter hop-derived compounds and their cognate bitter taste receptors. <i>Journal of Agricultural and Food Chemistry </i>2020, 68 (38): 10414-10423. IF (2020): 5.3. <a href="https://doi.org/10.1021/acs.jafc.9b07863" target="_top" title="DOI URL">doi: 10.1021/acs.jafc.9b07863</a></p> <p class="text-justify">Laghezza A, Piemontese L, Brunetti L, Caradonna A, Agamennone M, Di Pizio A, Pochetti G, Montanari R, Capelli D, Tauro M, Loiodice F, Tortorella P*. Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy. <i>Pharmaceuticals </i>2020, 13(6): 113. IF (2020): 5.7. <a href="https://doi.org/10.3390/ph13060113" target="_top">doi: 10.3390/ph13060113</a></p> <p class="text-justify">Lang T, Lang R, Di Pizio A, Mittermeier VK, Schlagbauer V, Hofmann T, Behrens M. Numerous compounds orchestrate coffee’s bitterness.<i> Journal of Agricultural and Food Chemistry </i>2020, 68 (24): 6692-6700. IF (2020): 5.3. <a href="https://doi.org/10.1021/acs.jafc.0c01373" target="_top" title="DOI URL">doi: 10.1021/acs.jafc.0c01373</a></p> <p class="text-justify">Leung N, Thakur DP, Gurav AS, Kim SH, Di Pizio A, Niv MY, Montell C*. Functions of Opsins in <i>Drosophila</i> Taste. <i>Current Biology </i>2020, 30: 1-13. IF (2020): 10.83. <a href="https://doi.org/10.1016/j.cub.2020.01.068" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.cub.2020.01.068</a></p> <p class="text-justify">Parma V, …, Di Pizio A, …, Hayes JE (GCCR). More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. <i>Chemical Senses </i>2020, 45(7), 609-62. IF (2020): 3.1. <a href="https://doi.org/10.1093/chemse/bjaa041" target="_top">doi: 10.1093/chemse/bjaa041</a></p> <p class="text-justify">Pellegrino R, Cooper KW, Di Pizio A, Joseph PV, Bhutani S, Parma V. Coronaviruses and the chemical senses: past, present, and future. <i>Chemical Senses </i>2020, 45(6): 415–422. IF (2020): 3.1. <a href="https://doi.org/10.1093/chemse/bjaa031" target="_top">doi: 10.1093/chemse/bjaa031</a></p> <p class="text-justify">Sabir F*, Di Pizio A, Loureiro-Dias MC, Casini A, Soveral G, Prista C. Insights into the Selectivity Mechanisms of Grapevine NIP Aquaporins. <i>International Journal of Molecular Sciences </i>2020, 21(18): 6697. IF (2020): 5.9. <a href="https://doi.org/10.3390/ijms21186697" target="_top">doi: 10.3390/ijms21186697</a></p> <p class="text-justify">Spaggiari G, Di Pizio A*, Cozzini P*. Sweet, umami and bitter taste receptors: State of the Art of <i>in silico</i> molecular modelling approaches. <i>Trends in food science & technology </i>2020, 96: 21-29. IF (2020): 12.6. <a href="https://doi.org/10.1016/j.tifs.2019.12.002" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.tifs.2019.12.002</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6805" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6806" class="frame frame-type-textmedia frame-layout-0"> <h2> 2019 </h2> <p class="text-justify">Arafeh R, Di Pizio A, Elkahloun AG, Dym O, Niv MY, Samuels Y*. RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma. <i>Oncogene</i> 2019, 38(13): 2432-2434. IF (2019): 6.7. <a href="https://doi.org/10.1038/s41388-018-0578-4" target="_top">doi: 10.1038/s41388-018-0578-4</a></p> <p class="text-justify">Dagan-Wiener A*, Di Pizio A, Nissim I, Bahia MS, Dubovski N, Margulis E, Niv MY*. BitterDB: taste ligands and receptors database in 2019. <i>Nucleic Acids Research</i> 2019, 47(D1): D1179-D1185. IF (2019): 11.2. <a href="https://doi.org/10.1093/nar/gky974" target="_top">doi: 10.1093/nar/gky974</a></p> <p class="text-justify">Di Pizio A*, Behrens M, Krautwurst D. Beyond the flavour: the potential druggability of chemosensory GPCRs. <i>International Journal of Molecular Sciences </i>2019, 20(6): 1402. IF (2019): 4.5. <a href="https://doi.org/10.3390/ijms20061402" target="_top">doi: 10.3390/ijms20061402</a></p> <p class="text-justify">Di Pizio A, Waterloo L, Brox R, Löber S, Weikert D, Behrens M*, Gmeiner P*, Niv MY*. Rational design of agonists for bitter taste receptor TAS2R14: from modelling to bench and back. <i>Cellular and Molecular Life Sciences </i>2020, 77: 531-542. IF (2019): 6.5. <a href="https://doi.org/10.1007/s00018-019-03194-2" target="_top">doi: 10.1007/s00018-019-03194-2</a></p> <p class="text-justify">Laghezza A, Luisi G, Caradonna A, Di Pizio A, Piemontese L, Loiodice F, Agamennone M*, Tortorella P*. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. <i>Bioorganic and Medicinal Chemistry</i> 2019, 28(3): 115257. IF (2019): 2.8. <a href="https://doi.org/10.1016/j.bmc.2019.115257" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.bmc.2019.115257</a></p> <p class="text-justify">Qin C, Qin Z, Zhao D, Pan, Zhuang L, Wan H, Di Pizio A, Malach E, Niv MY, Huang L, Hu N, Wang P*. A bioinspired in vitro bioelectronic tongue with human T2R38 receptor for high-specificity detection of N-C=S-containing compounds. <i>Talanta</i> 2019, 199: 131-139. IF (2019): 4.9. <a href="https://doi.org/10.1016/j.talanta.2019.02.021" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.talanta.2019.02.021</a></p> <p class="text-justify">Thawabteh A, Lelario F, Scrano L, Bufo SA, Nowak S, Di Pizio A, Niv MY, Behrens M, Karaman R*. Design, Synthesis and Functional studies of Bitterless Guaifenesin Prodrugs. <i>Chemical Biology & Drug Design</i> 2019, 93(3): 262-271. IF (2019): 2.4. <a href="https://doi.org/10.1111/cbdd.13409" target="_top">doi: 10.1111/cbdd.13409</a></p> <p class="text-justify">Wodak SJ*, Paci E, Dokholyan NV, Berezovsky IN, Horovitz A, Li J, Hilser VJ, Bahar I, Karanicolas J, Stock G, Hamm P, Stote RH, Eberhardt J, Chebaro Y, Dejaegere A, Cecchini M, Changeux J-P, Bolhuis PG, Vreede J, Faccioli P, Orioli S, Ravasio R, Yan L, Brito C, Wyart M, Gkeka P, Rivalta I, Palermo G, McCammon A, Panecka-Hofman J, Wade RC, Di Pizio A, Niv MY, Nussinov R, Tsai C-J, Jang H, Padhorny D, Kozakov D, McLeish T. Allostery in Its Many Disguises: From Theory to Applications. <i>Structure</i> 2019, 27: 566-578. IF (2019): 4.6. <a href="https://doi.org/10.1016/j.str.2019.01.003" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.str.2019.01.003</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6807" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6808" class="frame frame-type-textmedia frame-layout-0"> <h2> 2018 </h2> <p class="text-justify">Di Pizio A*, Agamennone M, Laghezza A, Loiodice F, Tortorella P. Mimic catechins to develop selective MMP-2 inhibitors. <i>Monatshefte für Chemie - Chemical Monthly</i> 2018, 149(7):1293-1300. IF (2018): 1.5. <a href="https://pubs.rsc.org/en/content/articlelanding/2019/md/c9md00165d" target="_top">doi: 10.1039/c9md00165d</a></p> <p class="text-justify">Di Pizio A, Ben Shoshan-Galeczki Y, Hayes JE, Niv MY*. Bitter and sweet tasting molecules: it's complicated. <i>Neuroscience Letters</i> 2018, 1(700): 56-63. IF (2018): 2.2. <a href="https://doi.org/10.1016/j.neulet.2018.04.027" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.neulet.2018.04.027</a></p> <p class="text-justify">Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M*. Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. <i>Biochimica et Biophysica Acta - General Subjects </i>2018, 1862(10): 2162-2173. IF (2018): 3.7. <a href="https://doi.org/10.1016/j.bbagen.2018.07.009" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.bbagen.2018.07.009</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6809" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6810" class="frame frame-type-textmedia frame-layout-0"> <h2> 2017 </h2> <p class="text-justify">Cheled-Shoval S, Behrens M, Korb A, Di Pizio A, Meyerhof W, Uni Z, Niv MY*. From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. <i>Molecules</i> 2017, 22(5): pii: E821. IF (2017): 3.1. <a href="https://doi.org/10.3390/molecules22050821" target="_top">doi: 10.3390/molecules22050821</a></p> <p class="text-justify">Di Pizio A*, Kruetzfeldt LM, Cheled-Shoval S, Meyerhof W, Behrens M, Niv MY*. Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case. <i>Scientific Reports</i> 2017, 7: 8223. IF (2017): 4.2. <a href="https://www.nature.com/articles/s41598-017-08344-9" target="_top">doi: 10.1038/s41598-017-08344-9</a></p> <p class="text-justify">Di Pizio A*, Shy N, Behrens M, Meyerhof W, Niv MY. Molecular features underlying selectivity in chicken bitter taste receptors. <i>Frontiers in Molecular Biosciences</i> 2017, 5: 6. IF (2017): 3.6. <a href="https://doi.org/10.3389/fmolb.2018.00006" target="_top">doi: 10.3389/fmolb.2018.00006</a></p> <p>Oren T, Nimri L, Yehuda-Shnaidman E, Staikin K, Hadar Y, Friedler A, Amartely H, Slutzki M, Di Pizio A, Niv MY, Perry I, Graeve L, Schwartz B*. Recombinant ostreolysin induces brown fat-like phenotype in HIB-1B cells. <i>Molecular Nutrition & Food Research</i> 2017, 61(9): 1-15. IF (2017): 5.2. <a href="https://doi.org/10.1002/mnfr.201700057" target="_top">doi: 10.1002/mnfr.201700057</a></p> <p>Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Hob P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y*. RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells. <i>Scientific Reports</i> 2017, 8: 653. IF (2017): 4.2. <a href="https://www.nature.com/articles/s41598-017-18851-4" target="_top">doi: 10.1038/s41598-017-18851-4</a></p> <p class="text-justify">Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY*. Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.<i> Frontiers in Molecular Biosciences</i> 2017, 5: 9. IF (2017): 3.6. <a href="https://doi.org/10.3389/fmolb.2018.00009" target="_top">doi: 10.3389/fmolb.2018.00009</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6811" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6812" class="frame frame-type-textmedia frame-layout-0"> <h2> 2016 </h2> <p class="text-justify">Di Pizio A, Agamennone M, Tortorella P*. Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process. <i>Current Topics in Medicinal Chemistry</i> 2016, 16(4): 449-59. IF (2016): 3.0, <a href="https://www.eurekaselect.com/article/69525" target="_top">doi: 10.2174/1568026615666150813150631</a></p> <p class="text-justify">Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY*. Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. In G Protein-Coupled Receptors: Signaling, Trafficking and Regulation (Shukla, A. K., Ed.), pp. 401-427.<i> Methods in cell biology </i>2016. IF (2016): 3.0, <a href="https://doi.org/10.1016/bs.mcb.2015.10.005" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/bs.mcb.2015.10.005</a></p> <p class="text-justify">Karaman R, Nowak S, Di Pizio A, Kitaneh H, Abu-Jaish A, Meyerhof W, Niv MY, Behrens M*. Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists. <i>Chemical Biology & Drug Design</i> 2016, 88(1): 66-75. IF (2016): 2.4, <a href="https://doi.org/10.1111/cbdd.12734" target="_top">doi: 10.1111/cbdd.12734</a></p> <p class="text-justify">Tauro M, Laghezza A, Loiodice F, Piemontese L, Caradonna A, Capelli D, Montanari R, Pochetti G, Di Pizio A, Agamennone M, Campestre C, Tortorella P*. Catechol-based matrix metalloproteinase inhibitors with additional anti-oxidative activity. <i>Journal of Enzyme Inhibition and Medicinal Chemistry</i> 2016, 24: 1-13. IF (2016): 4.3, <a href="https://doi.org/10.1080/14756366.2016.1217853" target="_top">doi: 10.1080/14756366.2016.1217853</a></p> <p class="text-justify"> </p> <p class="text-justify"><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> <div id="c6813" class="frame frame-type-div frame-layout-0"> <hr class="ce-div" /> </div> <div id="c6814" class="frame frame-type-textmedia frame-layout-0"> <h2> 2015 und früher </h2> <p class="text-justify">Arafeh R, Qutob N, Emmanuel R, Keren-Paz A, Madore J, Elkahloun A, Wilmott JS, Gartner JJ, Di Pizio A, Winograd-Katz S, Sindiri S, Rotkopf R, Dutton-Regester K, Johansson P, Pritchard AL, Waddell N, Hill VK, Lin JC, Hevroni Y, Rosenberg SA, Khan J, Ben-Dor S, Niv MY, Ulitsky I, Mann GJ, Scolyer RA, Hayward NK, Samuels Y*. Recurrent inactivating RASA2 mutations in melanoma. <i>Nature Genetics</i> 2015, 47(12): 1408-10. IF (2015): 31.6. <a href="https://www.nature.com/articles/ng.3427" target="_top">doi: 10.1038/ng.3427</a></p> <p class="text-justify">Di Pizio A, Aschi M, Agamennone M*. An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors. <i>PLOS ONE</i> 2012, 7(11): e47774. IF (2012): 4.3. <a href="https://doi.org/10.1371/journal.pone.0047774" target="_top">doi: 10.1371/journal.pone.0047774</a></p> <p class="text-justify">Di Pizio A, Laghezza A, Tortorella P, Agamennone M*. Probing the S1’ Site for the Identification of Non-Zinc-Binding MMP-2 Inhibitors. <i>ChemMedChem</i> 2013, 8(9): 1475-82. IF (2013): 3.3. <a href="https://doi.org/10.1002/cmdc.201300186" target="_top">doi: 10.1002/cmdc.201300186</a></p> <p class="text-justify">Di Pizio A and Niv MY*. Promiscuity and selectivity of bitter molecules and their receptors. <i>Bioorganic and Medicinal Chemistry</i> 2015, 23(14): 4082-91. IF (2015): 3.2. <a href="https://doi.org/10.1016/j.bmc.2015.04.025" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">doi: 10.1016/j.bmc.2015.04.025</a></p> <p class="text-justify">Di Pizio A and Niv MY*. Computational Studies of Smell and Taste Receptors. <i>Israel Journal of Chemistry</i> 2014, 54: 1205-1218. IF (2014): 2.9. <a href="https://doi.org/10.1002/ijch.201400027" target="_top">doi: 10.1002/ijch.201400027</a></p> <p class="text-justify">Ferrucci A, Leboffe L, Agamennone M, Di Pizio A, Fiocchetti M, Marino M, Ascenzi P*, Luisi G*. Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies. <i>Amino Acids</i> 2015, 47(1):153-62. IF (2015): 3.5. <a href="https://link.springer.com/article/10.1007/s00726-014-1855-3" target="_top">doi: 10.1007/s00726-014-1855-3</a></p> <p class="text-justify">Giustiniano M, Tortorella P, Agamennone M, Di Pizio A, Rossello A, Nuti E, Gomez-Monterrey I, Novellino E, Campiglia P, Vernieri E, Sala M, Bertamino A, Carotenuto A*. Amino acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors. <i>Journal of Amino Acids</i> 2013: 178381. <a href="https://doi.org/10.1155/2013/178381" target="_top">doi: 10.1155/2013/178381</a></p> <p> </p> <p><a href="#c6794" class="ti ti-none">zurück zum Seitenanfang</a></p> </div> </div> <div class="c-link-to-top js-link-to-top"> <a href="#topbar" title="nach oben springen"> To top </a> </div> </div> <div class="col-md-3 col-xl-2 c-content-area__aside js-link-checker"> <div id="sidebar" class="sidebar"> <aside class="c-aside"> <div id="c4114" class="frame frame-type-textmedia frame-layout-0"> <h2> Professur für Chemoinformatics and Protein Modelling </h2> <p><strong>Prof. Dr. Antonella Di Pizio</strong><br>Lise-Meitner-Straße 34<br>85354 Freising</p> <p>Tel.: +49 (0)8161 71 6516</p> <p><a href="#" data-mailto-token="wksvdy4k8nszsjsy8voslxsj7vclJdew8no" data-mailto-vector="10" class="mail ti ti-link-mail">E-Mail</a></p> </div> </aside> </div> </div> </div> </div> </main> <footer class="c-footer"> <div class="c-footer__legal"> <nav class="container" aria-label="legal links"> <ul class="list-inline"><li class="list-inline-item"><a href="/cpm/datenschutz/">Datenschutz</a></li><li class="list-inline-item"><a href="/cpm/impressum/">Impressum</a></li><li class="list-inline-item"><a href="/cpm/erklaerung-barrierefreiheit/">Barrierefreiheit</a></li></ul> <img aria-hidden="true" src="https://tum.de/hsts/default" height="1" width="1" /> </nav> </div> </footer> <script type="module" src="/_frontend/sitetum/bundled/assets/main-Ccf65gYE.js?1732803088"></script> <script data-ignore="1" data-dp-cookiedesc="layout" nonce="gPeutr_lKVazVtvZt2oL9clSEHWJw6UF3QdzQ_8frzAEsV5cmZpsgQ" type="text/plain"> Diese Webseite verwendet Cookies, um die Bedienfreundlichkeit zu erhöhen. <a aria-label="Weitere Informationen zu unseren verwendeten Cookies" class="cc-link" href="/cpm/datenschutz/#AktiveKomponenten" rel="noopener noreferrer nofollow" target="_blank" > Weitere Informationen </a> </script> <script data-ignore="1" data-dp-cookieselect="layout" nonce="gPeutr_lKVazVtvZt2oL9clSEHWJw6UF3QdzQ_8frzAEsV5cmZpsgQ" type="text/plain"> <div class="dp--cookie-check" xmlns:f="http://www.w3.org/1999/html"> <label for="dp--cookie-required"> <input class="dp--check-box" id="dp--cookie-required" tabindex="-1" type="checkbox" name="" value="" checked disabled> Notwendig </label> <label for="dp--cookie-statistics"> <input class="dp--check-box" id="dp--cookie-statistics" tabindex="1" type="checkbox" name="" value=""> Statistiken </label> </div> </script> <script data-ignore="1" data-dp-cookierevoke="layout" nonce="gPeutr_lKVazVtvZt2oL9clSEHWJw6UF3QdzQ_8frzAEsV5cmZpsgQ" type="text/plain"> <button type="button" aria-label="Cookie Consent widerrufen" class="dp--revoke {{classes}}" > <i class="dp--icon-fingerprint"></i> <span class="dp--hover">Cookies</span> </button> </script> <script data-ignore="1" data-dp-cookieiframe="layout" nonce="gPeutr_lKVazVtvZt2oL9clSEHWJw6UF3QdzQ_8frzAEsV5cmZpsgQ" type="text/plain"> <div class="dp--overlay-inner" data-nosnippet> <div class="dp--overlay-header">{{notice}}</div> <div class="dp--overlay-description">{{desc}}</div> <div class="dp--overlay-button"> <button class="db--overlay-submit" onclick="window.DPCookieConsent.forceAccept(this)" data-cookieconsent="{{type}}"> {{btn}} </button> </div> </div> </script> <script data-ignore="1" nonce="gPeutr_lKVazVtvZt2oL9clSEHWJw6UF3QdzQ_8frzAEsV5cmZpsgQ" type="text/javascript"> window.cookieconsent_options = { overlay: { notice: true, box: { background: 'rgba(48,112,179,.75)', text: '#fff' }, btn: { background: '#b81839', text: '#fff' } }, content: { message:'Diese Webseite verwendet Cookies, um die Bedienfreundlichkeit zu erhöhen.', dismiss:'Cookies zulassen!', allow:'Speichern', deny: 'notwendige <span></span>Cookies', link:'Weitere Informationen', href:'/cpm/datenschutz/', target:'_blank', 'allow-all': 'Alle akzeptieren!', config: 'Anpassen', 'config-header': 'Einstellungen für die Zustimmung anpassen', cookie: 'Cookies', duration: 'Duration', vendor: 'Vendor', media: { notice: 'Cookie-Hinweis', desc: 'Durch das Laden dieser Ressource wird eine Verbindung zu externen Servern hergestellt, die Cookies und andere Tracking-Technologien verwenden, um die Benutzererfahrung zu personalisieren und zu verbessern. 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