Parkinsons Disease

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It is characterized by the progressive loss of dopamine-producing neurons in the substantia nigra, a region of the brain. The deficiency of dopamine affects the coordination and regulation of movement, leading to the hallmark symptoms of PD.</div><div> <a href="https://neurocare.blog/knowledgebase/what-are-the-symptoms-of-parkinson-s-disease" title="What are the Symptoms of Parkinson's Disease?"><h3>What are the Symptoms of Parkinson's Disease?</h3></a> The symptoms of Parkinson's Disease can be categorized into motor and non-motor symptoms. </div><div> <a href="https://neurocare.blog/about/index/motor-symptoms" title="Motor Symptoms" target="_blank">Motor Symptoms</a>: These include tremors, rigidity, bradykinesia (slowness of movement), and postural instability. Tremors are often the most noticeable and typically start in one hand before progressing to other parts of the body.<br> <a href="https://neurocare.blog/about/index/non-motor-symptoms" title="Non-Motor Symptoms" target="_blank">Non-Motor Symptoms</a>: These can include cognitive impairment, mood disorders like depression and anxiety, sleep disturbances, and autonomic dysfunction (e.g., constipation, urinary problems).</div><div> <a href="https://neurocare.blog/knowledgebase/what-causes-parkinson-s-disease" title="What Causes Parkinson's Disease?"><h3>What Causes Parkinson's Disease?</h3></a> The exact cause of Parkinson's Disease remains unknown. However, it is believed to result from a combination of genetic and environmental factors. Certain genetic mutations have been linked to PD, and environmental exposures such as pesticides and heavy metals are also considered potential risk factors.</div><div> <a href="https://neurocare.blog/knowledgebase/how-is-parkinson-s-disease-diagnosed" title="How is Parkinson's Disease Diagnosed?"><h3>How is Parkinson's Disease Diagnosed?</h3></a> Diagnosing Parkinson's Disease typically involves a <a href="https://neurocare.blog/about/index/clinical-evaluation" title="clinical evaluation" target="_blank">clinical evaluation</a> by a neurologist. There is no specific test for PD, so diagnosis is based on medical history, a review of symptoms, and a neurological examination. In some cases, imaging studies like MRI or DAT scans may be used to rule out other conditions.</div><div> <a href="https://neurocare.blog/knowledgebase/what-treatments-are-available-for-parkinson-s-disease" title="What Treatments are Available for Parkinson's Disease?"><h3>What Treatments are Available for Parkinson's Disease?</h3></a> While there is no cure for Parkinson's Disease, treatment options aim to manage symptoms. </div><div> <a href="https://neurocare.blog/about/index/medications" title="Medications" target="_blank">Medications</a>: Levodopa is the most commonly prescribed medication and is often combined with carbidopa. Other medications include dopamine agonists, MAO-B inhibitors, and anticholinergics.<br> <a href="https://neurocare.blog/about/index/surgical-options" title="Surgical Options" target="_blank">Surgical Options</a>: Deep Brain Stimulation (DBS) is a surgical treatment where electrodes are implanted in specific brain regions to regulate abnormal impulses. It is usually considered when medication is no longer effective.<br> <a href="https://neurocare.blog/about/index/rehabilitation" title="Rehabilitation" target="_blank">Rehabilitation</a>: Physical therapy, occupational therapy, and speech therapy can help improve mobility, daily functioning, and communication skills.</div><div> <a href="https://neurocare.blog/knowledgebase/what-is-the-prognosis-for-parkinson-s-disease" title="What is the Prognosis for Parkinson's Disease?"><h3>What is the Prognosis for Parkinson's Disease?</h3></a> Parkinson's Disease is a progressive condition, meaning symptoms worsen over time. The rate of progression varies among individuals. While PD itself is not fatal, complications such as falls, infections, and aspiration pneumonia can lead to serious health issues. Early diagnosis and appropriate management can significantly improve the quality of life for patients.</div><div> <a href="https://neurocare.blog/knowledgebase/what-research-is-being-conducted" title="What Research is Being Conducted?"><h3>What Research is Being Conducted?</h3></a> Ongoing research aims to better understand the pathophysiology of Parkinson's Disease and to develop more effective treatments. Areas of research include <a href="https://neurocare.blog/about/index/gene-therapy" title="gene therapy" target="_blank">gene therapy</a>, stem cell therapy, and novel pharmacological approaches. Clinical trials are continually being conducted to test new interventions.</div><div> <a href="https://neurocare.blog/knowledgebase/how-can-patients-and-caregivers-cope" title="How Can Patients and Caregivers Cope?"><h3>How Can Patients and Caregivers Cope?</h3></a> Living with Parkinson's Disease can be challenging, but several strategies can help. Education about the disease, joining support groups, and maintaining a healthy lifestyle are essential. Caregivers should also seek support and respite care to manage their own well-being.</div><div> <h3>Conclusion</h3> Parkinson's Disease is a complex condition that requires a multidisciplinary approach for effective management. Advances in medical research continue to provide hope for better treatments and possibly a cure in the future. Patients and caregivers should work closely with healthcare providers to tailor a comprehensive care plan.</div></div> </div> <div id="recent_papers"> <br><hr /><br><h2 class="heading1">Relevant Publications</h2> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38768687" target='_blank' title="Exploring the complex interplay between Parkinson\'s Disease and BAG proteins.">Exploring the complex interplay between Parkinson\'s Disease and BAG proteins.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38693432" target='_blank' title="Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson\'s disease biomarker panel.">Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson\'s disease biomarker panel.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38960968" target='_blank' title="Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease.">Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38991885" target='_blank' title="Empowering the management of early-onset Parkinsons\' disease: The role of technology.">Empowering the management of early-onset Parkinsons\' disease: The role of technology.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38755717" target='_blank' title="Screening of key immunerelated gene in Parkinsons disease based on WGCNA and machine learning.">Screening of key immunerelated gene in Parkinsons disease based on WGCNA and machine learning.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38636468" target='_blank' title="Awake versus Asleep Anesthesia in Deep Brain Stimulation Surgery for Parkinson\'s Disease: A Systematic Review and Meta-Analysis.">Awake versus Asleep Anesthesia in Deep Brain Stimulation Surgery for Parkinson\'s Disease: A Systematic Review and Meta-Analysis.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37595486" target='_blank' title="The outcomes of constrained total hip arthroplasty for recurrent dislocation of hip hemiarthroplasty.">The outcomes of constrained total hip arthroplasty for recurrent dislocation of hip hemiarthroplasty.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37772285" target='_blank' title="Anthropology of Deep Brain Stimulation; the 30th Anniversary of STN DBS in 2023.">Anthropology of Deep Brain Stimulation; the 30th Anniversary of STN DBS in 2023.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37022414" target='_blank' title="Capturing the Abnormal Brain Network Activity in Early Parkinsons Disease with Mild Cognitive Impairment based on Dynamic Functional Connectivity.">Capturing the Abnormal Brain Network Activity in Early Parkinsons Disease with Mild Cognitive Impairment based on Dynamic Functional Connectivity.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/36637897" target='_blank' title="Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases.">Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/36740794" target='_blank' title="Andrographis paniculata and Andrographolide - A snapshot on Recent Advances in Nano Drug Delivery Systems Against Cancer.">Andrographis paniculata and Andrographolide - A snapshot on Recent Advances in Nano Drug Delivery Systems Against Cancer.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37024536" target='_blank' title="Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson\'s disease.">Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson\'s disease.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37794320" target='_blank' title="Design of the STEPS trial: a phase II randomized controlled trial evaluating eHealth-supported聽motor-cognitive home training for Parkinson\'s disease.">Design of the STEPS trial: a phase II randomized controlled trial evaluating eHealth-supported聽motor-cognitive home training for Parkinson\'s disease.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37689233" target='_blank' title="The biology, pathological roles of exosomes and their clinical application in Parkinsons disease.">The biology, pathological roles of exosomes and their clinical application in Parkinsons disease.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37426775" target='_blank' title="Deep brain stimulation, lesioning, focused ultrasound: update on utility.">Deep brain stimulation, lesioning, focused ultrasound: update on utility.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/37131734" target='_blank' title="Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.">Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.</a> </div> <p><strong>Issue Release:</strong> 2023</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/35560085" target='_blank' title="Is intermittent control the source of the non-linear oscillatory component (0.2-2Hz) in human balance control.">Is intermittent control the source of the non-linear oscillatory component (0.2-2Hz) in human balance control.</a> </div> <p><strong>Issue Release:</strong> 2022</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/36462371" target='_blank' title="MNC-Net: Multi-task graph structure learning based on node clustering for early Parkinson\'s disease diagnosis.">MNC-Net: Multi-task graph structure learning based on node clustering for early Parkinson\'s disease diagnosis.</a> </div> <p><strong>Issue Release:</strong> 2022</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/36911466" target='_blank' title="Prevalence and Risk Factors of Peripheral Neuropathy in Parkinson\'s Disease.">Prevalence and Risk Factors of Peripheral Neuropathy in Parkinson\'s Disease.</a> </div> <p><strong>Issue Release:</strong> 2022</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/35511847" target='_blank' title="Validation of a spatiotemporal gait model using inertial measurement units for early-stage Parkinson\'s disease detection during turns.">Validation of a spatiotemporal 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