CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.science.org",cType: 'managed',cRay: '92a826b42b5a4c71',cH: 'F8N.Uhj0i3jy453hG4QYEN39zkNTJWShMo3xffB86GA-1743678958-1.2.1.1-ns4qZHP9zR3eEenRKpLy7YOxh07AzaK4snOj1NDRDDIErtyTnGUbd7igYEaS0GSS',cUPMDTk: "\/doi\/10.1126\/science.2116664?__cf_chl_tk=bEcEIS1v2xP0h3VE5SKOcMOVTO3Eo8Iy7pJcXba4CFU-1743678958-1.0.1.1-GSN4Ic9VU8i1j8PhGHrQ16toz8ryYFJmqWH281lvYTo",cFPWv: 'g',cITimeS: '1743678958',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1126\/science.2116664?__cf_chl_f_tk=bEcEIS1v2xP0h3VE5SKOcMOVTO3Eo8Iy7pJcXba4CFU-1743678958-1.0.1.1-GSN4Ic9VU8i1j8PhGHrQ16toz8ryYFJmqWH281lvYTo",md: "kIYOOC7f_86OBvo95695Awbl.d9v8lNTX008stWOphU-1743678958-1.2.1.1-Z5UoLr5neDI0QD.pqmbRjqNWt5Ct5WnNv5wfS.ZgoURpEJJqBv13WU1KYlX9eGPaD0jQgJ5UA1TwHvXx2TIx.lU_F831FITcGDZ80pxG2tZfLDyXzvj96djgfrxkzmx0VJRS3uqksJEhQsuL9j.dmyCAwbrLG4bLr77jJMFvDVD20d9wyVl3IHwWHVXzLZXAepX7lAqrXBO3p0tcIxMRLnQyhrkSuAd25ZTs289InhkYTPis1dgtWrbZj_h4ye1NwEcBrGF5deNtJgzmXaNnMyTC8V3LbW9OJaJIRo.ciUyhquJX.0.sFluhFuHAINeNy918hIMH_EggCxvGacNAFGXwNYkVatfoBW1EszpyBaq4DPMXa1iKdvFR5ptxc9ZdS9bSzUR1tmUC5HXecXtvpnby8eCmlRnNhMsMGlygavqFtHAHAX.OC7c1iIeqZLaBg4PcuIfkO4mVBwtzSj_y76gGO3jjNnVYRAFxp2sS9.3Yh1GN1zmCctFQ16m.zjuskP_YyirSuuKYJ2CpZvUMhQgm61eZT1CD6V8K5Iei.LJuzbXlxcdX8OBiF4FwQEF4O_UD8R.F.cwT.KYrMXK6yxGGSDtK6lzwQZVjMwdC.rorWXtn_pvBI5LIU1UtUh2NnoSZqidewQftfCjZ7nOZg8u.ttOftlLoiND9.a_MUc1ntNNDaTJighyaYhlXhyg9gfTxlpUoWHoRSUMFv2aprkABaDwWkQq2GQh3M6IRFdLfFRPeLuuVI5smraw8hNW21VRzp7HK1F6MAghu7cPgqbb9rLBGDyTCpjIqV0iQZkkaAxVPqocH6DeQ1thDz8849kIwuScVlGJ7NtP_JK8VmeYIiD2vKfthueRBtAteHwO6ZjIndrqItdeAxQeZNCk1.LQz8oR2_RQcYfLWEwDADhQOy3BCVA28wfxOYHdMntRkPIgpyvr6agbjqcv1jlTYB6Wm3qo8dEhqmvnIYGrXEJVXNiJLRX34uRM.rnb3q4o06rJ.MzL7Md5LRR1jPDqLT0sgcJdpra2ZnUBY4ux21qCLX3YCVx8P.TdfzlwDw.dm_nkET8XyhVQIwAQo.N5gDkg31WELBljhV9taIB0qGDkNkVPidYf4YsLC_vLKxq_Ckce81Bj8_XAcD56y8otcV2Z4oyuJUJ2Zo7HgZBTdn1rBNWxowZmb_i_jY_qlBR1Lll8lYrDc5gIZ50UDV7wo9Oajrf63t3rbEJuVYOJJGHpAuR2QKlkWN5LdKf7qmU3Cuk2hh_UqF7eaZPNBTKo_WmP1GfCDGNjYEbsKC4jtBA",mdrd: "ZEhj2Ed5FteO5fJcCfYJq7BI6VCLL3DmBl4jAMYcJ0A-1743678958-1.2.1.1-jqwU1sxYXtP1UzPmlmiS2K4gWz_JMfHXUy5Ne90S2URDbkMEaSTrDfGlWs7zVAZTSubD9oFawArqrVyt.h2_6YEQg_Hy24xf74txd7ps6F4_s9jSRpuR.I1Y0JFdvXtG8b28LtCIUL3_hbrQ.zSst.ZF3A9aJrn.BYIs3ttjKrDvwha1OyifX47qMy4KlTl1z0lrt3zkGKPzV0ergZCqi1wmt9JINwP3yUqMjktRaaE4Cy0PyhW1hiNGL2xdXcEzFpt1b81eASp91P4.LXhG3oM.u6o47ZqRUwPR7zbvSAqBWaMl9RZyCSshyIDOK3rH9MlY26euNTP4v6g1VUgKKqIAOFLMhSg7CHowI1A.oinloPQAICSq_ZJZQ6HFOfwD_Vou0cN0Ct_wyCVxojXAr.9kE7lo81MsHh5p_BJ4iHMY12deqGBOmlYYUneFUWiS1bq94E3.twoHsUkLIrl0eaiHmLeKtQy_.ld4_5OkKDWrhWJzzovTu1M3yWUPfzgi_axIKPN2Hnh9yIn3DUyxrIGswEOZlCq0NnA8FiFOeNcuVH3oWSXHvqJcvrwqx9fTX0M9H30tO5peNSVogFGoLQHEiwtpgwrOAdGBjbmbMwaUCUb2oq.JEPbWbEJFotnbL_wBvwvyblNkZUj1C23N11.IthzJjBNN4uAECCbCZeZ6.FsA.KpqfpUpiSx3OcCQT.CkQs9qos19tUmgY3RDg1vWOiKeZgrLb8_XyeYvLscCD_crxsklcL.gpiy.PbyKx6Bm9rQtVxeuFBGhjtTIfeub1V_anqMahQyJF0PAtppJWgjn8Rb.D0uNlkiplR3ye65GDulUfFXOrt4ACn.zmoEfZzA1bw7Y8W2P_EwAFO7mIaozwRtXZe2CnnBS.qTckU_L5ZGj1w0Tz1faKAw9LE8l0ooBLTePVhWtWhcOwAniBr4hJK7ASBqVfgzWEPt6yQTMfeoeIk5bSI7BWEq1zyP7weDuYzbMFhl_QVYXr69AKvmC5ySNikbYyAAkFjjWPytrwLx_ACMEU6GvZYvKAINyl_9.rUkPMvh4q6TBF8AF4WkrpgbPWgGDNP6m6nElnUJCFZZTkqi2PF3.xIOJSZMlEkxuubaPdVqC200rPcPyMH_5VtIQTdSFEXgzVIEBmdivXcfzHQZ6xUZq8Kjbn9ABqHEhVxZ7vjs4DZ9lOAJ6DKUDvfkKMm6w9f11fyDxM3P2oYqN6dUGTPbb7HAM.3WYxzZkvbVtXwSKS7mJlk55gBzaPLjHsbDN3k4nV5i1gu.DVvMU7mLj2dA9g7dF5CumPV6GzkNx7Bg.5jI5OG_SMWR7PDb7StpYgrBEPw0s_j3IR.OfnJCUhAKWwfU7ZrjUIJHOAxRG0gCOHnW7neVKC9V.3Zt5VbF8VNdRkPvC672l9R_8bqo5Tn9c05vLFL4mZkYNQAUaoLZjviuD7is.kx05V_HGsU987HH9Fq7XRMX8nBvDnUNAjzhLu6.cju52MIqDLJRb8Bs4W8wc9cA8R9peoKCrZjfgIs9_jT6XFxhkR84IOxfhMtVeiU9Ky7VoJwZdBZY4QM2LK2cjKBngDX.foaKMMDayE0Wy8rs4FCAaFsWxCvkMDsfNYQtLrwlI9LZ.WzPzuG1o2d92vmMN1cT.Z0dOSDBnQVVo96SxlaVlHgBTAKx1HR7AknzZA9HzjE0XGa4kZJTFlJQmYE2Y58nOdGrkA1bvxxsFdGCBIFUFIonr5MqtX3qmf.PqMK_CwN7xDG3oHCM2ge3mCYBaWvKhxW7VI6BQfCWnHUApMxmQ0EMc2obigaTr2lO1ZRuiLO6eFliDiNCWjyo5hefER5S6R5bQdwDi_b1I4ErJNp_KJPfL0_ipG3btPZgJ7nGxO7becyjiWoYRPRz9m76mJ2jib5NRtWRYu2Q.zhaDFjeomauL9kz7hCgfciLoVzVThqHOHC4UOSW6L250QtnjwtgL2QOY4MpFJooGUb4C4xaq0rYC4PLfeZOpjuGxfNKu3Vx3RmaOK67eWxUZRNt1rKflyhpyxNKmQk993PTtiMlj8BP7YLcdF.geks8RbQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=92a826b42b5a4c71';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1126\/science.2116664?__cf_chl_rt_tk=bEcEIS1v2xP0h3VE5SKOcMOVTO3Eo8Iy7pJcXba4CFU-1743678958-1.0.1.1-GSN4Ic9VU8i1j8PhGHrQ16toz8ryYFJmqWH281lvYTo" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>