安罗替尼联合AN方案一线治疗晚期EGFR、ALK及ROS1野生型肺腺癌的疗效

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 ">广东医学</a>. <a onclick="
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 " dbcode="CJFQ"><div class="row"><span class="rowtit">摘要：</span><span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的探讨安罗替尼联合AN方案一线治疗晚期野生型肺腺癌患者的有效性和安全性。方法收集肿瘤科诊治的ⅢB～Ⅳ期野生型[表皮生长因子受体（epidermal growth factor receptor, EGFR）、间变性淋巴瘤激酶（anaplastic lymphoma kinase, ALK）及ROS1基因均为野生型]的肺腺癌患者,观察组（接受安罗替尼+培美曲塞+奈达铂方案）患者22例,对照组（接受培美曲塞+奈达铂方案）患者26例。对两组患者进行疗效、不良反应观察。结果近期客观疗效对比,观察组的客观缓解率（ORR）和疾病控制率（DCR）分别为50%和86.4%,优于对照组的ORR（30.8%）和DCR（61.5%）,但组间比较均差异无统计学意义（P＞0.05）。观察组中位无进展生存时间（median progress-free survival, mPFS）较对照组延长1.54个月（9.38个月vs 7.84个月,P＜0.05）;观察组总生存期（overall survival, OS）较对照组延长1.06个月（11.52个月vs 10.46个月）,但差异无统计学意义（P＞0.05）。两组患者的治疗相关不良反应发生率对比,观察组在手足综合征、疲劳及高血压方面发生率高于对照组,且组间差异有统计学意义（P＜0.05）。结论安罗替尼联合AN方案较AN方案一线治疗晚期野生型肺腺癌的近期疗效有获益趋势,可改善晚期野生型肺腺癌患者的一线治疗疾病控制时间,在总生存上尚未见获益。</span><span><a id="ChDivSummaryMore" onclick="MoerSummary('ChDivSummary','ChDivSummaryMore','ChDivSummaryReset')" style="display:none">更多</a><a id="ChDivSummaryReset" onclick="ResetSummary('ChDivSummary','ChDivSummaryMore','ChDivSummaryReset')" style="display:none">还原</a></span></div><script type="text/javascript"> AbstractFilter('ChDivSummary','ChDivSummaryMore','ChDivSummaryReset'); </script><div class="row"><span class="rowtit">关键词：</span><p class="keywords"><a target="_blank" onclick="
 TurnPageToKnetV('kw','安罗替尼','','');
 ">安罗替尼; </a><a target="_blank" onclick="
 TurnPageToKnetV('kw','非小细胞肺癌','','');
 ">非小细胞肺癌; </a><a target="_blank" onclick="
 TurnPageToKnetV('kw','肺腺癌','','');
 ">肺腺癌; </a><a target="_blank" onclick="
 TurnPageToKnetV('kw','野生型','','');
 ">野生型; </a><a target="_blank" onclick="
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 ">培美曲塞; </a><a target="_blank" onclick="
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 ">奈达铂; </a></p> </div> <div class="row"> <ul> <li class="top-space"><span class="rowtit">DOI：</span><p>10.13820/j.cnki.gdyx.20200278</p> </li> <li class="top-space"><span class="rowtit">专辑：</span><p>医药卫生科技</p> </li> <li class="top-space"><span class="rowtit">专题：</span><p>肿瘤学</p> </li> <li class="top-space"><span class="rowtit">分类号：</span><p>R734.2</p> </li> </ul> </div> <div id="zqfilelist"></div> <div class="operate" id="DownLoadParts"> <div class="operate-left"> <ul class="operate-btn"> <li class="btn-phone"><a href="javascript:void(0);"><i></i>手机阅读<em class="icon-trangle"></em></a><div class="tip-pop"> <div class="inner"> <h6>即刻使用手机阅读</h6> <div class="fl first"><img alt="" src="/KCMS/detail/resource/gb/images/icon-qrcode-download.jpg
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