Official journal of the American College of Gastroenterology

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name="wkhealth_issue" content="6" /><meta name="wkhealth_article_publication_date" content="April 16, 2019" /><meta name="wkhealth_volume" content="114" /><meta name="wkhealth_ovid_accession_number" content="00000434-201906000-00027" /><meta name="wkhealth_issn" content="0002-9270" /><meta name="wkhealth_title" content="Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium" /><meta name="wkhealth_authors" content="Pesek, Robert D.;Reed, Craig C.;Muir, Amanda B.;Fulkerson, Patricia C.;Menard-Katcher, Calies;Falk, Gary W.;Kuhl, Jonathan;Martin, Ellen K.;Magier, Adam Z.;Ahmed, Faria;Demarshall, Maureen;Gupta, Ankur;Gross, Jonathan;Ashorobi, Tokunbo;Carpenter, Christina L.;Krischer, Jeffrey P.;Gonsalves, Nirmala;Spergel, Jonathan M.;Gupta, Sandeep K.;Furuta, Glenn T.;Rothenberg, Marc E.;Dellon, Evan S.;on behalf of the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)" /><meta name="wkhealth_doi" content="10.14309/ajg.0000000000000228" /><meta name="wkhealth_abstract_html_url" content="https://journals.lww.com/ajg/abstract/2019/06000/increasing_rates_of_diagnosis,_substantial.27.aspx" /><meta name="wkhealth_fulltext_html_url" content="https://journals.lww.com/ajg/fulltext/2019/06000/increasing_rates_of_diagnosis,_substantial.27.aspx" /><meta name="wkhealth_toc_section" content="ARTICLE" /><meta name="wkhealth_toc_sub_section" content="PEDIATRICS" /><meta name="wkhealth_eJpId" content="ajg:2019:06000:00027" /><meta name="wkhealth_firstpage" content="984" /><meta name="wkhealth_date" content="June 2019" /><meta name="wkhealth_pdf_url" content="https://journals.lww.com/ajg/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=Other&an=00000434-201906000-00027" /><meta name="Description" content="OBJECTIVES: The literature related to eosinophilic gastritis (EG), gastroenteritis (EGE), and col" /><meta property="og:site_name" content="LWW" /><meta property="og:type" content="article" /><meta property="og:title" content="Increasing Rates of Diagnosis, Substantial Co-Occurrence,... : Official journal of the American College of Gastroenterology | ACG" /><meta property="og:description" content="collected from 6 centers in the Consortium of Eosinophilic Gastrointestinal Researchers from 2005 to 2016. We analyzed demographics, time trends in diagnosis, medical history, presenting symptoms, disease overlap, and initial treatment patterns/responses. RESULTS: Of 373 subjects (317 children and 56 adults), 38% had EG, 33% EGE, and 29% EC. Rates of diagnosis of all diseases increased over time. There was no male predominance, and the majority of subjects had atopy. Presenting symptoms were similar between diseases with nausea/vomiting and abdominal pain, the most common. One hundred fifty-four subjects (41%) had eosinophilic inflammation outside of their primary disease location with the esophagus the second most common gastrointestinal (GI) segment involved. Multisite inflammation was more common in children than in adults (68% vs 37%; P < 0.001). Initial treatment patterns varied highly between centers. One hundred-nine subjects (29%) had follow-up within 6 months, and the majority had clinical, endoscopic, and histologic improvements. CONCLUSIONS: In this cohort, EG, EGE, and EC were diagnosed more frequently over time, and inflammation of GI segments outside the primary disease site co-occurrence of atopy was common with a lack of male predominance. Symptoms were similar between diseases, and initial treatment strategies were highly variable. Future investigation should assess the cause of the increased prevalence of eosinophilic GI disorders and prospectively assess outcomes to establish treatment algorithms...." /><meta property="og:image" content="https://images.journals.lww.com/ajg/SocialThumb.00000434-201906000-00027.T1.jpeg" /><meta property="og:image:width" content="2080" /><meta property="og:image:height" content="2323" /><meta property="og:url" content="https://journals.lww.com/ajg/fulltext/2019/06000/increasing_rates_of_diagnosis,_substantial.27.aspx" /><meta property="twitter:card" content="summary" /><meta name="robots" content="index, follow, noarchive" /><meta name="WT.sv" content="ZUSE1PEJPWEB01" /><meta name="Title" content="Official journal of the American College of Gastroenterology | ACG" /><style id="SPThemeHideForms" type="text/css">body {opacity:0 !important}</style>  <link href="https://fonts.googleapis.com/css?family=Arvo:400,400i,700|Fira+Sans:300,300i,400,400i,500,500i,600,600i,700,700i&display=swap" rel="stylesheet" /> <script> // temporary workaround for Bug 316328:[Stage][Registration][Regression 05.04] - Omniture events are not displayed for article viewer page // prevents JS exception in Adobe launch.js caused by situation when wkhealth_institution_type meta tag is present while wkhealth_institution_name tag is not in the page head // see this check in Adobe launch.js: null != document.querySelector("meta[name='wkhealth_institution_name']") ... // TODO: implement proper code fix after release 05.04.00 deployment var wkhealth_institution_type = document.querySelector("meta[name='wkhealth_institution_type']"); var wkhealth_institution_name = document.querySelector("meta[name='wkhealth_institution_name']"); console.warn(wkhealth_institution_type); console.warn(wkhealth_institution_name); if (wkhealth_institution_type && !wkhealth_institution_name) { 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376)","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.T1.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.T1.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=T1&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.T1.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_T1");images["T2"]=new image("T2","F1","T1","Table 2.","Medical history of study population and by EGID diagnosis","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.T2.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.T2.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=T2&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.T2.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_T2");images["F1"]=new image("F1","T3","T2","Figure 1.","(<strong xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">a</strong>) Time trends for EGID diagnoses between 2005 and 2016. (<strong xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">b</strong>) Frequency of EGID by diagnosis and year.","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.F1.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.F1.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=F1&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.F1.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_F1");images["T3"]=new image("T3","T4","F1","Table 3.","Presenting symptoms by EGID diagnosis","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.T3.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.T3.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=T3&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.T3.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_T3");images["T4"]=new image("T4","T5","T3","Table 4.","Frequency of eosinophilic inflammation outside of the site of the primary disorder","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.T4.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.T4.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=T4&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.T4.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_T4");images["T5"]=new image("T5","F2","T4","Table 5.","Initial treatment of EGID by diagnosis sorted by type of medication and diet modification","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.T5.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.T5.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=T5&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.T5.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_T5");images["F2"]=new image("F2","T6","T5","Figure 2.","Initial medical treatments sorted by center and eosinophilic gastrointestinal disorder diagnosis demonstrating high variability in treatment approaches. Bars represent percentage of treatment utilized; subjects could receive more than 1 treatment per disease. (<strong xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">a</strong>) Initial treatments utilized for eosinophilic gastritis. PPI was the most commonly used medication (61%) followed by topical steroids (23%) and systemic steroids (20%); 58% were treated with food elimination diets. (<strong xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">b</strong>) Initial treatments utilized for eosinophilic gastroenteritis. PPI was the most commonly used medication (60%) followed by systemic steroids (24%); 68% were treated with food elimination diets. (<strong xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">c</strong>) Initial treatments utilized for eosinophilic colitis. PPI was the most commonly utilized medication (30%) followed by 5-ASA (25%), systemic steroids (19%), and enteric-coated budesonide (19%). Food elimination diets were utilized in 58% of cases. Multiple treatments were initiated in 41% of subjects across all disorders. 5-ASA, 5-aminosalicyclic acid; PPI, proton-pump inhibitor.","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.F2.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.F2.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=F2&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.F2.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_F2");images["T6"]=new image("T6","F3","F2","Table 6.","Treatment responses by disease and measure of change","https://images.journals.lww.com/ajg/Rollover.00000434-201906000-00027.T6.jpeg","https://images.journals.lww.com/ajg/Gallery.00000434-201906000-00027.T6.jpeg","https://journals.lww.com/ajg/_layouts/oaks.journals/ImageView.aspx?k=ajg:2019:06000:00027&i=T6&year=2019&issue=06000&article=00027&type=Abstract","https://images.journals.lww.com/ajg/Original.00000434-201906000-00027.T6.jpeg","/ajg/pages/imagegallery.aspx?year=2019&issue=06000&article=00027", "ajg_2019_06000_00027_T6");images["F3"]=new image("F3","","T6","Figure 3.","Change in peak tissue eosinophil count after the initiation of treatment, by disease. Bars represent the total number of tissue eosinophils per high-powered field before and after treatment of eosinophilic gastrointestinal disorder diagnosis. Of the 376 subjects enrolled, 109 (29%) had follow-up within 6 months of starting initial treatment. Endoscopy was completed in 40 (32%) with eosinophilic gastritis, 42 (42%) with eosinophilic gastroenteritis, and 14 (15%) with eosinophilic colitis subjects. 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document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenOvidId').value = ovidId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Topical(title, journalId, topicalCollectionId) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Topical'; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenTopicalCollectionId').value = topicalCollectionId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') { document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId; } if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCSuccessPopup() { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } $('.js-close').on('click', function() { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.hide(); } return false; }); </script> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl"></span> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscribeToEtocPopupState" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState" value="showemail" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenConfirmSubscriptionPageUrl" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenJournalId" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscriptionType" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType" /> <div id="divPopupOverLay" class="Popup-Overlay" style="display: none; position: fixed; left: 0; top: 0; z-index: 3800; width: 1920px; height: 4517px;"></div> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc" class="etoc-popup ej-box-modal-drop-shadow" style="display: none;"> <div tabindex="-1" role="dialog" class="wk-modal horizontally-centered small wk-modal-with-overlay wk-modal-small ejp-modal"> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain" onkeypress="javascript:return WebForm_FireDefaultButton(event, 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue')"> <section class="wk-modal-content"> <header class="wk-modal-header ejp-modal-header"> <div class="wk-modal-title ejp-modal-title"> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblTitle"></span> </div> <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "> <i class="fa fa-times"></i> </button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <div class="wk-field-body"> <strong> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage"></span></strong> </div> <div class="wk-field-body"> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError" style="color:Black;display:none;"> <div class="ej-error-message"> <p class="ej-error-message-icon error-red"> </p> </div> </span> <label for="Email input">Enter your Email address:</label> <div class="wk-field-body"> <input name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$txtEmailAddress" type="text" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress" class="ej-box-modal-style-1-input" /> </div> </div> <div class="wk-button-bar"> <div class="wk-button-group-left"> <input type="submit" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue" value="Continue" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue", "", true, "", "", false, false))" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue" class="primary-button" /> <input type="button" value="Cancel" id="btnCancel" class="js-close secondary-button" /> </div> </div> </div> <div class="wk-field-item"> <div class="wk-field-body"> <a id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hypPrivacy" href="https://journals.lww.com/ajg/_layouts/oaks.journals/privacy.aspx" target="_blank">Privacy Policy</a> </div> </div> </div> </section> </div> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser" style="display: none;"> <section class="wk-modal-content"> <header class="wk-modal-header ejp-modal-header"> <div class="wk-modal-title ejp-modal-title"></div> <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <p> <strong> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle"></span> </strong> </p> </div> <p id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pAuthenticatedUserMessage"> </p> </div> </section> </div> </div> </div> <div id="ej-clear-float"> </div> <script type="text/javascript"> function 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document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState'); var emailTextBox = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress'); var thanksPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser'); var mainPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain'); var thankYouMessageUnAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage'); var thankYouMessageAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle'); if (!displaySubscriptionType) { displaySubscriptionType = subscriptionType; } if (modelPopupState.value == 'showthanksmessage') { thanksPanel.style.display = "block"; mainPanel.style.display = "none"; thankYouMessageAuthenticated.innerHTML = "Thank you for subscribing to the " + displaySubscriptionType + " for " + journalTitle + "."; } if (modelPopupState.value == 'showemail') { thanksPanel.style.display = "none"; mainPanel.style.display = "block"; thankYouMessageUnAuthenticated.innerHTML = "Thank you for choosing to subscribe to the " + displaySubscriptionType + " for " + journalTitle + "."; } if ($('.etoc-popup') != null) { document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').value = journalId; if (modelPopupState.value == 'showemail') emailTextBox.focus(); } } $('.js-close').on('click', function () { document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress').value = ""; document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError').style.display = "none"; var pageUrl = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl'); var subscribeeTocPopup = $find('subscribeToEtoc'); if (subscribeeTocPopup != null) { subscribeeTocPopup.hide(); document.getElementsByTagName( 'html' )[0].classList.remove('no-scroll'); if (pageUrl.value !== '' && pageUrl.value !== window.location.pathname) window.location = pageUrl.value; } return false; }); </script> <div id="ctl00_ctl51_Header_UserActionTools_eTocTopContainer"> <div id="eTocTop" style="display: none;"> <a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup('Official journal of the American College of Gastroenterology | ACG','ajg','eTOC', 'eTOC');;" onclick="javascript: alerts_ShowSubscribeeTOCPopup('Official journal of the American College of Gastroenterology | ACG','ajg','eTOC', 'eTOC');"><span id="ctl00_ctl51_Header_UserActionTools_alertLinkControlTop_defaultText" class="hideOnFixed">Subscribe to eTOC</span></a> 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href="https://journals.lww.com/ajg/pages/default.aspx"> <h3 class="logo-main-text">Journal Logo </h3> </a> <div class="search-v2"> <div class="search-wrapper"> <select name="ctl00$ctl51$Header$SearchTopBoxControl$ddlContentScope" id="ctl00_ctl51_Header_SearchTopBoxControl_ddlContentScope"> <option value="All">All</option> <option selected="selected" value="Articles">Articles</option> <option value="Images">Images</option> <option value="Videos">Videos</option> <option value="Podcasts">Podcasts</option> <option value="Blogs">Blogs</option> </select> <div class="input-group" id="globalSearch"> <input name="ctl00$ctl51$Header$SearchTopBoxControl$txtKeywords" type="text" value="Search" id="ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords" class="form-control searchText" /> <span class="input-group-btn"> <button id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier" type="submit" class="btn btn-default"><i class="fa fa-search"></i></button> </span> <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$IsAutoCompleteEnabled" id="ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled" value="false" /> <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$AutocompleteApiUrl" id="ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl" value="https://platformservices.wolterskluwerhealth.com/autocomplete/AJGAST/shingle/" /> </div> </div> <div class="advance-search" style=""> <a id="ctl00_ctl51_Header_SearchTopBoxControl_lnkAdvanceSearch" href="https://journals.lww.com/ajg/pages/advancedsearch.aspx">Advanced Search</a> <input type="submit" name="ctl00$ctl51$Header$SearchTopBoxControl$btnGlobalSearch" value="" id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch" disabled="disabled" class="aspNetDisabled btnGlobalSearch" style="display: none;" /> <input name="ctl00$ctl51$Header$SearchTopBoxControl$hfldKeywords" type="hidden" id="ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords" class="hfldKeywords" value="disableButton" /> </div> </div> <script> $(function() { try { var objSearchBox = { btnGlobalSearchMagnifierId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier', searchButtonId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch', txtKeywordsId: 'ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords', hfldKeywordsHiddenId: 'ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords', defaultSearchText: 'Search' }; new Searchbox(objSearchBox).Init(); } catch (e) { console.error(e); } }); //autocomplete functionality for basic search //this functionality will call the SBA url and start suggesting after typing 3rd character var textKeywords = null; var hiddenAutocompleteApiUrl = null; var buttonGlobalSearch = null; $(function () { try { var objAutocomplete = { hiddenIsAutoCompleteEnabled: $('#ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled'), textKeywords: $('#ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords'), hiddenAutocompleteApiUrl: 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MD, PhD; Barmada, M. Michael PhD; Ewers, Maren MSc; Ruffert, Claudia; Paliwal, Sumit PhD; Issarapu, Prachand MSc; Bhaskar, Seema PhD; Mani, K. Radha BSc; Chandak, Giriraj R. MD, PhD; Laumen, Helmut PhD; Masson, Emmanuelle PhD; Kume, Kiyoshi MD, PhD; Hamada, Shin MD, PhD; Nakano, Eriko MD, PhD; Seltsam, Katharina; Bugert, Peter MD; M\u00FCller, Thomas MD; Groneberg, David A. MD; Shimosegawa, Tooru MD; Rosendahl, Jonas MD; F\u00E9rec, Claude MD, PhD; Lowe, Mark E. 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Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium', '04162019', 'Robert D. Pesek, Craig C. Reed, Amanda B. Muir, et al', '114', '6', '\u00A9 2019 by The American College of Gastroenterology', '00000434-201906000-00027', '', false, ''); } </script> <div id="ArticleContainer"> <article id="ej-abstract-view" xmlns:ssr="http://ssr-eus-go-csi.cloudapp.net/v1/assets" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xhtml="http://www.w3.org/1999/xhtml"><section class="ejp-r-article-subsection"><div class="ejp-r-article-subsection__text">ARTICLE: PEDIATRICS</div></section><header class="ejp-article-header"><h1 class="ejp-article-title">Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium</h1></header><section id="ejp-article-authors"><p id="P7">Pesek, Robert D. MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">1</sup>; Reed, Craig C. MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup>; Muir, Amanda B. MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>; Fulkerson, Patricia C. MD, PhD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">4</sup>; Menard-Katcher, Calies MD, MSCS<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">5</sup>; Falk, Gary W. MD, MS<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">6</sup>; Kuhl, Jonathan BS<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">4</sup>; Martin, Ellen K. BS<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">1</sup>; Magier, Adam Z. BS<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">4</sup>; Ahmed, Faria BA<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">5</sup>; Demarshall, Maureen BSN, RN<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">6</sup>; Gupta, Ankur BA<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>; Gross, Jonathan BA<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>; Ashorobi, Tokunbo MPH<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>; Carpenter, Christina L. MPH<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">7</sup>; Krischer, Jeffrey P. PhD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">7</sup>; Gonsalves, Nirmala MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">8</sup>; Spergel, Jonathan M. MD, PhD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">9</sup>; Gupta, Sandeep K. MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">10</sup>; Furuta, Glenn T. MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">5</sup>; Rothenberg, Marc E. MD, PhD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">4</sup>; Dellon, Evan S. MD, MPH<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup>; 聽on behalf of the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)</p><section><a href="#" id="ejp-article-authors-link"> Author Information <i class="wk-icon-arrow-down-r"></i></a></section></section><section id="ejp-article-authors-info" class="ejp-article-authors-info ejp-article-authors-info--hidden"><div class="ejp-article-authors-info-holder"> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">1</sup>Division of Allergy/Immunology, Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup>Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">4</sup>Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">5</sup>Division of Gastroenterology, Department of Pediatrics, Children's Hospital Colorado, Denver, Colorado, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">6</sup>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">7</sup>Rare Disease Clinical Research Network Data Coordinating Center, Health Informatics Institute, University of South Florida, Tampa, Florida, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">8</sup>Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">9</sup>Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine of University of Pennsylvania, Philadelphia, Pennsylvania, USA;</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">10</sup>Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Illinois and the University of Illinois College of Medicine, Peoria, Illinois, USA.</p> <p id="cor1"><strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">Correspondence:</strong> Robert D. Pesek, MD. E-mail: <span><a href="/cdn-cgi/l/email-protection#771a161e1b03184d0513071204121c3702161a0459121302" onclick="javascript:window.open('mailto:mailto:rdpesek@uams.edu');return false"><span class="__cf_email__" data-cfemail="077563776274626c4772666a7429626372">[email protected]</span></a></span>.</p> <p id=""><strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">SUPPLEMENTARY MATERIAL</strong> accompanies this paper at <span><a href="https://links.lww.com/AJG/A170" onclick="javascript:window.open('https://links.lww.com/AJG/A170');return false">https://links.lww.com/AJG/A170</a></span> and <span><a href="https://links.lww.com/AJG/A171" onclick="javascript:window.open('https://links.lww.com/AJG/A171');return false">https://links.lww.com/AJG/A171</a></span></p> </div></section><section id="article-journal-info"><div class="ej-journal-info"><span class="ej-journal-name">The American Journal of Gastroenterology </span><span id="ej-journal-date-volume-issue-pg"><a href="/ajg/toc/2019/06000">114(6):p 984-994, June 2019.</a></span><span> | </span><span class="ej-journal-doi">DOI: </span>10.14309/ajg.0000000000000228</div></section><section id="ejp-article-indicators" class="ejp-article-indicators"><ul class="ejp-article-indicators__list"> <li id="ej-article-indicators-buy" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()"><a href="#ContentAccessOptions"><span class="ejp-indicator">Buy</span></a></li> <li id="ej-article-indicators-sam" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_SDC()" onmouseout="javascript:Tooltip_MouseOut()"><span class="ejp-indicator">SDC</span></li> </ul><button id="openArticleMetricsPopupButton" type="button" class="wk-button wk-button-ghost wk-button-icon-left ejp-article-metrics-btn" data-articleMetricsEndpoint="//services.journals.lww.com/IntegrationServices/ArticleMetricsService.svc" data-articleMetricsDetailsUrl="https://wolterskluwer.altmetric.com/details/" data-doi="10.14309/ajg.0000000000000228" data-suiteId="vrs_woltere_journalsglobalvrs" data-articlePublicationDate="2019-04-16" data-articlePublicationDateString="April 16, 2019" data-receivedDate="2018-08-14" data-revisionReceivedDate="" data-acceptedDate="2019-03-04" data-crossrefRefLinkRoot="https://doi.org/" data-medlineRefLinkRoot="http://www.ncbi.nlm.nih.gov/pubmed/" data-pubMedId="31008735"><i class="wk-icon-filled-chart-r"></i><i class="wk-icon-filled-chart-white-r"></i> Metrics </button></section><section class="ejp-article-tabs" id="abstractWrap"><h2 class="ejp-article-tabs-heading">Abstract</h2> <div class="ejp-article-tabs__tabpanel" id="panel1" role="tabpanel" aria-labelledby="tab1"> <div id="article-abstract-content1"> <div class="ejp-article-text-abstract"> <h3>OBJECTIVES: </h3> <p>The literature related to eosinophilic gastritis (EG), gastroenteritis (EGE), and colitis (EC) is limited. We aimed to characterize rates of diagnosis, clinical features, and initial treatments for patients with EG, EGE, and EC.</p> <h3>METHODS: </h3> <p>In this retrospective study, data were collected from 6 centers in the Consortium of Eosinophilic Gastrointestinal Researchers from 2005 to 2016. We analyzed demographics, time trends in diagnosis, medical history, presenting symptoms, disease overlap, and initial treatment patterns/responses.</p> <h3>RESULTS: </h3> <p>Of 373 subjects (317 children and 56 adults), 38% had EG, 33% EGE, and 29% EC. Rates of diagnosis of all diseases increased over time. There was no male predominance, and the majority of subjects had atopy. Presenting symptoms were similar between diseases with nausea/vomiting and abdominal pain, the most common. One hundred fifty-four subjects (41%) had eosinophilic inflammation outside of their primary disease location with the esophagus the second most common gastrointestinal (GI) segment involved. Multisite inflammation was more common in children than in adults (68% vs 37%; <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">P</em> < 0.001). Initial treatment patterns varied highly between centers. One hundred-nine subjects (29%) had follow-up within 6 months, and the majority had clinical, endoscopic, and histologic improvements.</p> <h3>CONCLUSIONS: </h3> <p>In this cohort, EG, EGE, and EC were diagnosed more frequently over time, and inflammation of GI segments outside the primary disease site co-occurrence of atopy was common with a lack of male predominance. Symptoms were similar between diseases, and initial treatment strategies were highly variable. Future investigation should assess the cause of the increased prevalence of eosinophilic GI disorders and prospectively assess outcomes to establish treatment algorithms.</p> </div> </div> </div></section><section class="ej-article-copyright">漏 2019 by The American College of Gastroenterology</section></article> </div> </div> <section id="ContentAccessOptions" class="article-not-authorized-msg"> <div class="ejp-access-options-wrapper"> <div class="ejp-access-options ejp-access-options--desktop"> <div id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_FullTextAccessOptionsContainer" class="ejp-access-options__subscriber-access"> <h3 class="ejp-access-options__subscriber-access-title">Full Text Access for Subscribers:</h3> <div class="ejp-access-options__subscriber-access-society-list"> <div id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_PrimaryLoginBox" class="box-ssologin primary-login-box"> <a href="https://journals.lww.com/ajg/pages/login.aspx?ReturnUrl=%2fajg%2fabstract%2f2019%2f06000%2fincreasing_rates_of_diagnosis%2c_substantial.27.aspx&IsLoginLinkClicked=true" id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_hypLoginTop" class="ssologin-link"> <div class="ssologin-ico"> <img src="https://cdn.wolterskluwer.io/wk-logos/1.0.x/wk-brand-wheel.svg" alt="click to login here" /> </div> <div class="ssologin-link__text"> <h5 class="ssologin-link__primary-text">Individual Subscribers</h5> <span class="ssologin-link__secondary-text">Log in for access</span> </div> <i class="wk-icon-arrow-right ssologin-link__icon"></i> </a> </div> <div class="box-ssologin"> <a id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_ssoListControl_ssoListView_ctrl0_singleSignOnControl_ssoLoginLink" class="ssologin-link" href="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("ctl00$ctl29$g_05816bca_ab8a_4648_9820_e541e93c2483$ctl00$ssoListControl$ssoListView$ctrl0$singleSignOnControl$ssoLoginLink", "", true, "", "", false, true))"> <div id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_ssoListControl_ssoListView_ctrl0_singleSignOnControl_ssoImageContainer" class="ssologin-ico"> <img src="https://journals.lww.com/ajg/PublishingImages/logos/sso-logo.png" id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_ssoListControl_ssoListView_ctrl0_singleSignOnControl_ssoImage" alt="Log In Here" /> </div> <div class="ssologin-link__text"> <h5 id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_ssoListControl_ssoListView_ctrl0_singleSignOnControl_loginLinkPrefix" class="ssologin-link__primary-text">ACG Member Access</h5> <span id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_ssoListControl_ssoListView_ctrl0_singleSignOnControl_loginLinkText" class="ssologin-link__secondary-text">Log In Here</span> </div> <i class="wk-icon-arrow-right ssologin-link__icon"></i> </a> </div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript"> // hide top message for SSO login $(function () { $('.ejp-login__message--top').addClass('dn'); 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class="wk-modal-slideshow__source-article mb4"> <a href="javascript:void(0);" id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_slideShowUserControl_sourceArticleUrl" onclick="HideSlideShow();">Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter...</a> </div> <div id="ctl00_ctl29_g_05816bca_ab8a_4648_9820_e541e93c2483_ctl00_slideShowUserControl_citationdiv" class="wk-modal-slideshow__source-citation mb4"> Official journal of the American College of Gastroenterology | ACG114(6):984-994, June 2019. </div> </div> </div> <div class="modal-footer wk-modal-footer wk-modal-slideshow__footer pa2 flex flex-column flex-wrap"> <div class="wk-modal-slideshow__zoom-controls flex justify-between items-center mb2"> <div id="zoom_buttons" class="wk-modal-slideshow__zoom-buttons flex justify-between"> <a href="#" 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