Conference Day 1 - 4th mRNA-Based Therapeutics Europe

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col-md-12"> <article class="fl-post post-595 page type-page status-publish has-post-thumbnail hentry" id="fl-post-595" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-595 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="595"><div class="fl-row fl-row-full-width fl-row-bg-none fl-node-kfr5yon1aj3m fl-row-default-height fl-row-align-center" data-node="kfr5yon1aj3m"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-po3f6vcn94ab" data-node="po3f6vcn94ab"> <div class="fl-col fl-node-u9jiq1tdbnpf fl-col-bg-color fl-col-has-cols" data-node="u9jiq1tdbnpf"> <div class="fl-col-content fl-node-content"> <div class="fl-col-group fl-node-90nl1bt2xgfi fl-col-group-nested" data-node="90nl1bt2xgfi"> <div class="fl-col fl-node-pni3thvjk6qo fl-col-bg-photo" data-node="pni3thvjk6qo"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-gxitleaj79fd" data-node="gxitleaj79fd"> <div class="fl-module-content fl-node-content"> <h1 class="fl-heading"> <span class="fl-heading-text">Conference Day One</span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-none fl-node-d5ctvuz0pj9m fl-row-default-height fl-row-align-center" data-node="d5ctvuz0pj9m"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-a8bug0v47kd2" data-node="a8bug0v47kd2"> <div class="fl-col fl-node-btxwap0q54is fl-col-bg-color fl-col-has-cols" data-node="btxwap0q54is"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-1pkr2xv8dlqc" data-node="1pkr2xv8dlqc"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #d4e8eb"> <h3> <span class="time"> </span> <span style="color: #029990;">7.20 Check In & Morning Coffee </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #f1f5f6"> <h3> <span class="time"> 8:20 am </span> Chair’s Opening Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25040" class="view-speaker" speaker-id="25040"><span>Andreas Kuhn</span></a></em> Sen. Vice President RNA Biochemistry & CMC Development, BioNTech SE </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #d4e3eb"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #006496;">Visions for the Future of mRNA & Beyond: The Leadership Perspective </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #f3f6f8"> <h3> <span class="time"> 8:30 am </span> <span style="color: #00a566;">CEO & Global Leaders Think Tank:</span> Unlocking the Next Frontiers of mRNA-Based Vaccines & Therapeutics to Ensure Better Drugs Reach Patients Faster </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24875" class="view-speaker" speaker-id="24875"><span>Ansgar Santel</span></a></em> Chief Executive Officer & Head of Translational Research & Alliance Management, Pantherna Therapeutics </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24548" class="view-speaker" speaker-id="24548"><span>Jenny van Asbeck – van der Wijst</span></a></em> Chief Executive Officer, Mercurna </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24876" class="view-speaker" speaker-id="24876"><span>Nigel Horscroft</span></a></em> Chief Technology Officer, Stealth Mode mRNA Biotech </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24877" class="view-speaker" speaker-id="24877"><span>Alexander Zehnder</span></a></em> Chief Executive Officer, CureVac </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24878" class="view-speaker" speaker-id="24878"><span>Bo Ying</span></a></em> Chief Executive Officer, Abogen Biosciences </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25130" class="view-speaker" speaker-id="25130"><span>Pierre Wils</span></a></em> Global Scientific Advisory Lead, Sanofi </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>What are the future opportunities for the mRNA field towards best-in-class drugs into 2025?</li> <li>What are the biggest challenges you face on a day-to-day basis from asset, deals to risk-management and clinical strategy? </li> <li>What can biotechs get most out of an investment to extend cash-flow and nuances of striking a deal for a new pipeline?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #f3f6f8"> <h3> <span class="time"> 9:30 am </span> Current Cancer Vaccine Strategies Including Initial Phase 1 Study Data of CVGBM, an Off-the-Shelf Cancer Vaccine in Glioblastoma </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24879" class="view-speaker" speaker-id="24879"><span>Dr. Myriam Mendila</span></a></em> Chief Scientific Officer and Head of R&D, CureVac </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Cancer vaccines based on mRNA technologies have shown encouraging clinical data over the last couple of years </li> <li>Showcasing current strategies to develop cancer vaccines focus on either personalized cancer vaccines or off-the-shelf cancer vaccines </li> <li>Presenting CVGBM, an off-the-shelf cancer vaccine, that demonstrated encouraging immunogenicity in a phase 1 study in patients with GBM after tumor resection</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #f0f0f0"> <h3> <span class="time"> 10:00 am </span> Showcasing Clinical Trial Experience & Data from BNT116 – The UK’s First mRNA-Based Lung Cancer Vaccine Trial </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25220" class="view-speaker" speaker-id="25220"><span>Siow Ming Lee</span></a></em> Professor of Medical Oncology, University College London </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #e5f4f4"> <h3> <span class="time"> </span> <span style="color: #029990;">10:30 Morning Break & Speed Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> <div class="fl-col-group fl-node-gcx1ksm35iyu fl-col-group-nested" data-node="gcx1ksm35iyu"> <div class="fl-col fl-node-etol1hacgx8u fl-col-bg-color fl-col-small" data-node="etol1hacgx8u"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-r53jbhi4mxt6" data-node="r53jbhi4mxt6"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #006699"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #ffffff;">TRACK A: DISCOVERY & PRE-CLINICAL DEVELOPMENT<br> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><strong style="color: rgb(255, 255, 255); font-size: 14px;">Chair: </strong><span style="color: rgb(255, 255, 255); font-size: 14px;">Nigel Horscroft, Chief Technology Officer, Stealth Mode mRNA Biotech</span></p> </div>  </div> <div class="inner-agenda" style="background: #7caec6"> <h3> <span class="time"> </span> <span style="font-size:20px;"><center><span style="color: #ffffff;">Showcasing New Discoveries in mRNA Medicine From Asia to Unlock Platforms for Obesity & Antibody Production </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #e6f0f5"> <h3> <span class="time"> 11:30 am </span> Advancing mRNA Therapeutics: A New Frontier in the Treatment of Obesity & Metabolic Disease </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24880" class="view-speaker" speaker-id="24880"><span>Xiangrong Song</span></a></em> Chief Executive Officer & Co-Founder, WestGene Pharma </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Presenting breakthrough advances in mRNA-based therapeutics for the treatment of obesity using WestGene’s proprietary platform technologies </li> <li>Highlighting preclinical data demonstrating significant weight loss and metabolic improvements, setting the stage for upcoming clinical trials </li> <li>Exploring the broader potential of WestGene’s mRNA platform to address metabolic diseases and expand therapeutic opportunities</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #e6f0f5"> <h3> <span class="time"> 12:00 pm </span> Session Reserved for Henovcom </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #e6f0f5"> <h3> <span class="time"> 12:30 pm </span> Harnessing <I> In Vivo </I>Therapeutic Antibody Production Enabled by mRNA-LNP Technology </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24881" class="view-speaker" speaker-id="24881"><span>Yeong-Chan Ahn</span></a></em> Senior Manager, SML Biopharm </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Outlining novel mRNA-LNP platform for mRNA therapeutic antibody production </li> <li>Exploring therapeutic antibody potential from discovery to pre-clinical development </li> <li>Overcoming key challenges of in vivo protein expression for successful translation of mRNA-based therapeutics</li> </ul> </div>  </div> </div> </div> </div> </div> </div> <div class="fl-col fl-node-58l0zuptqjgk fl-col-bg-color fl-col-small" data-node="58l0zuptqjgk"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-auf9ho0wypdb" data-node="auf9ho0wypdb"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #00a566"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #ffffff;">TRACK B: CLINICAL DEVELOPMENT & MANUFACTURING </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><strong style="color: rgb(255, 255, 255); font-size: 14px;">Chair:</strong><span style="color: rgb(255, 255, 255); font-size: 14px;"> Ruben Rizzi, Senior Vice President Global Regulatory Affairs, BioNTech</span></p> </div>  </div> <div class="inner-agenda" style="background: #80d2b3"> <h3> <span class="time"> </span> <span style="font-size:20px;"><center><span style="color: #ffffff;">Deciphering a Regulatory Framework & Guidance for Future mRNA Platforms to Harmonise Clinical & Manufacturing Development </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #e4f4ee"> <h3> <span class="time"> 11:30 am </span> The Value of a Harmonised Regulatory Framework for mRNA Medicines </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24882" class="view-speaker" speaker-id="24882"><span>Maren Von Fritschen</span></a></em> Head of Regulatory Policy Europe, Moderna </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>mRNA platform technology approaches supported by regulatory provisions </li> <li>Diverse regulatory understanding of platform technology from various perspectives </li> <li>Examples of platform technology – platform technology approaches today and in the future</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #e4f4ee"> <h3> <span class="time"> 12:00 pm </span> Session Reserved for Ziccum </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #e4f4ee"> <h3> <span class="time"> 12:30 pm </span> Swiss Regulatory Aspects & Evaluation for mRNABased Vaccines & Therapeutic Pathways to Approval </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24883" class="view-speaker" speaker-id="24883"><span>Julia Djonova</span></a></em> Head Division Advanced Therapy Medicinal Products, Swiss Agency for Therapeutic Products, Swissmedic, Swissmedic </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Exploring harmonisation regulatory challenges and expectations for new mRNA drugs applications and documentation </li> <li>Delineating the mRNA platform definition for vaccine, therapeutic and broader applications </li> <li>Highlighting regulatory progress in personalised mRNA cancer vaccines and manufacturing considerations</li> </ul> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-module fl-module-ee-agenda fl-node-zv4h5taxoqjk" data-node="zv4h5taxoqjk"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #d4e8eb"> <h3> <span class="time"> </span> <span style="color: #029990;">1.00 Lunch Break & Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> <div class="fl-col-group fl-node-sglm20ep6d3f fl-col-group-nested" data-node="sglm20ep6d3f"> <div class="fl-col fl-node-h1amkj3btsvd fl-col-bg-color fl-col-small" data-node="h1amkj3btsvd"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-jrdu12h9exn7" data-node="jrdu12h9exn7"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #006699"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #ffffff;">TRACK A: DISCOVERY & PRE-CLINICAL DEVELOPMENT </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><strong style="color: rgb(255, 255, 255); font-size: 14px;">Chair: </strong><span style="color: rgb(255, 255, 255); font-size: 14px;">Nigel Horscroft, Chief Technology Officer, Stealth Mode mRNA Biotech</span></p> </div>  </div> <div class="inner-agenda" style="background: #80b3cc"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #ffffff;">Turbocharging new mRNA-LNP Programs to Expand Therapeutic Potential with European Research Initiatives & Collaborations </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #dee8ec"> <h3> <span class="time"> 2:00 pm </span> <span style="color:#f49517;">REGeRNA Project: </span>Identifying & Developing mRNAEncoded Proteins Towards Novel Therapeutics for Cardiac Tissue Regeneration </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24884" class="view-speaker" speaker-id="24884"><span>Philippe Menasche</span></a></em> Professor - Thoracic & Cardiovascular Surgery, University of Paris-Cité </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Establishing the need for new treatments of heart failure </li> <li>Deciphering a rationale for an mRNA-based strategy for reinducing proliferation of cardiomyocytes Showcasing first results and remaining challenges</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #dee8ec"> <h3> <span class="time"> 2:30 pm </span> Multidimensional Characterisation of RNA-Based Vaccines & Therapies </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25221" class="view-speaker" speaker-id="25221"><span>Wayne Doyle</span></a></em> Head of Platform, Eclipse Bioinnovations </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Evaluate potency through the identification of ribosome stalls that reduce protein production</li> <li>Examine purity by discovering the sequences and structures that lead to dsRNA by-products</li> <li>Measure safety through studies of off-target changes in transcription and translation</li> </ul> <p></p> </div>  </div> <div class="inner-agenda" style="background: #dee8ec"> <h3> <span class="time"> 3:00 pm </span> <span style="color:#f49517;">BAXERNA Project: </span>On a Mission to Develop Novel Bacterial mRNA Vaccines </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24885" class="view-speaker" speaker-id="24885"><span>Lyudmila Kovalchuke</span></a></em> Project Manager, VIB-UGent </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Introducing BAXERNA’s aim to develop mRNA vaccines against bacterial infections like TB and beyond Showcasing the development of a novel antigen discovery to Phase I pipeline for fully realised bacterial vaccines</li> <li>Showcasing the development of a novel antigen discovery to Phase I pipeline for fully realised bacterial vaccines</li> <li>Unlocking LNP formulation, mRNA format, and analytical development for novel mRNA vaccines</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #dee8ec"> <h3> <span class="time"> 3:30 pm </span> <span style="color:#f49517;">EXPERT Project: </span>Immunostimulatory Triplet mRNA Cocktail in Lipid Nanoparticles for Cancer Therapy </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24886" class="view-speaker" speaker-id="24886"><span>Raymond Schiffelers</span></a></em> Professor of Nanomedicine, UMC Utrecht </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Developing a new LNP with a mRNA-encoded cytokine mix </li> <li>Demonstrating scaled-up LNP production and characterization </li> <li>Unleashing new delivery system on the horizon: Cell penetrating peptides and extracellular vesicles</li> </ul> </div>  </div> </div> </div> </div> </div> </div> <div class="fl-col fl-node-odbzf56ea431 fl-col-bg-color fl-col-small" data-node="odbzf56ea431"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-g6xqb0hmr14w" data-node="g6xqb0hmr14w"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #00a566"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #ffffff;">TRACK B: CLINICAL DEVELOPMENT & MANUFACTURING </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><strong style="color: rgb(255, 255, 255); font-size: 14px;">Chair:</strong><span style="color: rgb(255, 255, 255); font-size: 14px;"> Andreas Kuhn, Senior Vice President – RNA Biochemistry & CMC, BioNTech SE</span></p> </div>  </div> <div class="inner-agenda" style="background: #80d2b3"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #ffffff;">Forging New Commercial Partnerships to Ensure Smooth Transfer into Trials & Manufacturing at Scale </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:00 pm </span> Unlocking mRNA Vaccines: From Platform to Products </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25130" class="view-speaker" speaker-id="25130"><span>Pierre Wils</span></a></em> Global Scientific Advisory Lead, Sanofi </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Developing an mRNA competitive platform requires a high level of collaboration between designers and developers of mRNA and LNPs </li> <li>Evolving from platform to product needs to build the desired biological performance and the CMC performance into the design of mRNA and LNPs </li> <li>Data science is the continuum that provides acceleration to the overall mRNA Vaccines development</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #e6f6f0"> <h3> <span class="time"> 2:30 pm </span> Vinylphosphonic Acid Modified Cap Analogs and Their Performance in mRNA Vaccines </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25286" class="view-speaker" speaker-id="25286"><span>May Guo</span></a></em> CCO, Areterna </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Development of Vinylphosphonic Acid Modified Cap GAG (CAP5011) and GAU (CAP1811) </li> <li>Synthesis of mRNA using CAP5011 and CAP1811, and encapsulation in LNP </li> <li>Testing of mRNA capped with CAP5011 and CAP1811, including protein expression, vaccine induced immune response in vivo and mRNA safety in NHP.</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #e6f6f0"> <h3> <span class="time"> 3:00 pm </span> Panel Discussion — Finding the Right Partnership to Build a Robust & Trusting Relationship to Accelerate mRNA Development Into the Clinic </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24888" class="view-speaker" speaker-id="24888"><span>Verena Mummert</span></a></em> Director Alliance Management, Ethris </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24889" class="view-speaker" speaker-id="24889"><span>James Lee</span></a></em> Senior Director, Search and Evaluation, Everest Medicines </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24551" class="view-speaker" speaker-id="24551"><span>Gilles Divita</span></a></em> CEO, Divincell </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24890" class="view-speaker" speaker-id="24890"><span>Vincent Serra</span></a></em> Chief Scientific & Operating Officer, Neovacs </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>The mRNA community thrives on strategic alliances, which allow for cross-functional sharing of knowledge, skills, and experience across different disciplines to truly advance mRNA technologies to accelerate drug development to patients faster. </p> <p></p> <p>This panel will explore: </p> <p></p> <ul> <li>How to overcome the complexities of decision-making and cultural boundaries for developing, acquiring, licensing and advancing innovative approaches </li> <li>Where are the gaps when using mRNA approaches that the service provider, biotechnology and academic sector can fill? </li> <li>Developing successful expertise in house vs external sourcing management vs asset acquisition partnering strategies</li> </ul> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-module fl-module-ee-agenda fl-node-n8cdxkewlbu3" data-node="n8cdxkewlbu3"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #e6f5f5"> <h3> <span class="time"> </span> <span style="color: #029990;">4.00 Afternoon Break & Poster Session </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="color: rgb(2, 153, 144);">As the landscape of innovation that is supercharging the next wave of efficacious mRNA vaccines and therapeutics, it is more important than ever to collaborate and learn for the growth of this field. Join our dedicated poster session to share your latest data and get the first look into what your peers are working on!</span></p> </div>  </div> <div class="inner-agenda" style="background: #d7e5ec"> <h3> <span class="time"> </span> <span style="font-size:22px;"><center><span style="color: #006496;">Accelerating Effective & Safe Personalised mRNA Cancer Immunotherapies Towards Clinical Success & Achieving Market Approval </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #ecf0f2"> <h3> <span class="time"> 4:30 pm </span> Presenting MHRA’s Perspectives & Draft Guidance on the Licensing of Individualised mRNA Cancer Immunotherapies </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24891" class="view-speaker" speaker-id="24891"><span>Shirley Hopper</span></a></em> Deputy Director National Licensing Strategy, Medicines & Healthcare products Regulatory Agency </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Individualised mRNA cancer immunotherapies (cancer vaccines) pose new regulatory challenges since the mRNA sequence is matched to the patient’s unique tumour neoantigen profile and HLA type </li> <li>The MHRA aims to publish draft scientific and regulatory guidance for developers of individualised mRNA cancer vaccines by the end of 2024. This will include sections on regulations, manufacturing, non-clinical, clinical and post-authorisation aspects </li> <li>An overview of the key points will be presented</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #ecf0f2"> <h3> <span class="time"> 5:00 pm </span> Session Reserved for Thermo Fisher Scientific </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:30 pm </span> A European Industry & Regulatory Perspective on the Development & Approval of mRNA Medicines </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24882" class="view-speaker" speaker-id="24882"><span>Maren Von Fritschen</span></a></em> Head of Regulatory Policy Europe, Moderna </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24891" class="view-speaker" speaker-id="24891"><span>Shirley Hopper</span></a></em> Deputy Director National Licensing Strategy, Medicines & Healthcare products Regulatory Agency </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24894" class="view-speaker" speaker-id="24894"><span>Ruben Rizzi</span></a></em> Senior Vice President - Global Regulatory Affairs, BioNTech AG </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24883" class="view-speaker" speaker-id="24883"><span>Julia Djonova</span></a></em> Head Division Advanced Therapy Medicinal Products, Swiss Agency for Therapeutic Products, Swissmedic, Swissmedic </li> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker25222" class="view-speaker" speaker-id="25222"><span>Ulrike Jägle</span></a></em> Vice President Global Regulatory Affairs & Preclinical Safety, CureVac SE </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Uncovering how regulatory provisions can support mRNA medicines’ approval </li> <li>Reducing the regulatory approval timeline through platform technology approaches </li> <li>Moving towards a harmonized approach for mRNA medicines for the benefit of patients</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 6:15 pm </span> Chair’s Closing Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://mrnabased-therapeutics-europe.com/speakers/#speaker24882" class="view-speaker" speaker-id="24882"><span>Maren Von Fritschen</span></a></em> Head of Regulatory Policy Europe, Moderna </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 6:25 pm </span> End of Conference Day One </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-none fl-node-6149a7ea135d8 fl-row-default-height fl-row-align-center fl-animation fl-fade-up" data-node="6149a7ea135d8" data-animation-delay="0" data-animation-duration="1"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-4nzf0bsq9oka" data-node="4nzf0bsq9oka"> <div class="fl-col fl-node-wi18k4urz32o fl-col-bg-color fl-col-small" data-node="wi18k4urz32o"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button fl-node-6149bdfed99db fl-animation fl-fade-up" data-node="6149bdfed99db" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-button-wrap fl-button-width-full fl-button-center"> <a href="https://mrnabased-therapeutics-europe.com/pre-conference-day/" target="_self" class="fl-button"> <span class="fl-button-text">PRE-CONFERENCE DAY</span> </a> </div> </div> </div> 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mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cb735f42d5d2',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cf92200ec99d',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'54',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-wmloa8v9tbg6 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} 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