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The Role of Blood Markers in Predicting Ectopic Pregnancy Outcomes – Gynecology
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category-ectopic-pregnancy tag-blood-markers tag-complete-blood-count tag-ectopic-pregnancy tag-methotrexate tag-micrornas tag-neutrophil-to-lymphocyte-ratio tag-platelet-distribution-width tag-predictive-markers tag-tubal-ectopic-pregnancy tag--hcg" itemtype="https://schema.org/CreativeWork" itemscope> <div class="inside-article"> <div class="featured-image page-header-image-single "> <img width="1200" height="628" src="https://gynecology.blog/archive/wp-content/uploads/2024/10/banner-21-2-min-scaled-e1730111375935.jpg" class="attachment-full size-full" alt="" itemprop="image" decoding="async" fetchpriority="high" /> </div> <header class="entry-header"> <h1 class="entry-title" itemprop="headline">The Role of Blood Markers in Predicting Ectopic Pregnancy Outcomes</h1> <div class="entry-meta"> <span class="posted-on"><time class="entry-date published" datetime="2024-10-28T15:59:43+05:30" itemprop="datePublished">October 28, 2024</time></span> <span class="byline">by <span class="author vcard" itemprop="author" itemtype="https://schema.org/Person" itemscope><a class="url fn n" href="https://gynecology.blog/archive/author/gynecology/" title="View all posts by gynecology" rel="author" itemprop="url"><span class="author-name" itemprop="name">gynecology</span></a></span></span> </div> </header> <div class="entry-content" itemprop="text"> <h4><b>Introduction</b></h4> <p><span style="font-weight: 400;">Ectopic pregnancy is a very often potentially life-threatening syndrome wherein an already fertilized egg starts implanting outside the uterus, normally in the fallopian tube. Early diagnosis and appropriate treatment for EP is highly recommended because of a high risk for maternal morbidity and mortality, especially during the first trimester. Proper care and prompt diagnosis of EP are of great importance. </span></p> <p><span style="font-weight: 400;">Blood markers are one of the most valuable tools for the diagnosis and prognosis of ectopic pregnancies. Beta-human chorionic gonadotropin (β-hCG), complete blood count (CBC) values, and other serum markers play an important role in the diagnosis of EP, evaluating the severity of the disease, and predicting the outcome of drug treatments or the need for surgery. For instance, levels of β-hCG and other such markers as NLR or neutrophil-to-lymphocyte ratio and PDW or platelet distribution width can predict the response of medical intervention in a patient with an ectopic pregnancy, even to methotrexate therapy.</span></p> <h4><b>The Importance of Early Diagnosis and Blood Markers</b></h4> <p><span style="font-weight: 400;">There is a great deal of need for early detection of an ectopic pregnancy to avoid some problems like rupture of the tube, internal bleeding, and even death in extreme cases. Blood indicators help assess the effectiveness of meds like methotrexate, which are commonly prescribed for patients medically stable, and to predict the existence of an ectopic pregnancy.β-hCG is among the main indicators used for the diagnosis of ectopic pregnancy. The pace of increasing or decreasing levels of β-hCG can be very informative about the viability of pregnancy. In early gestation, levels of β-hCG in normal intrauterine pregnancies rise very rapidly within 48 to 72 hours; whereas in ectopic pregnancies, levels often rise more slowly or even fall. </span></p> <p><span style="font-weight: 400;">There are many literatures that explain how β-hCG levels can usefully direct treatment decisions, as in selection of methotrexate for treatment.β-hCG levels have been shown to be indicative of treatment success. Usually, the decrease in the β-hCG values post-methotrexate treatment often informs whether treatment has been successful or not and necessitates surgery. It is for this reason that β-hCG is an important marker that provides significant documentation both regarding the diagnosis of ectopic pregnancy and during assessment of success of methotrexate and other conservative treatments.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Yearwise Publication Trend on <b>“<a href="https://gynecology.blog/publication-trends/index/ectopic pregnancy" target="_blank" title="ectopic pregnancy - yearwise publication trends">ectopic pregnancy</a>”</b></h2> </div> </div><div class="results-container"><div class="chart-block" style="padding:15px;"> <div class="left"> <div id="results" class="results"></div> </div> <div class="right"> <div class="chart-container"><canvas id="publicationChart"></canvas></div> </div> <div class="keywordsdiv"> <div style="text-align:center;"><b>Find publication trends on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-stats"></span> </div> </div></div></div><div class="inside-article"><style> table { margin: 0 0 1.5em; 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if (!statistics || Object.keys(statistics).length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var tableHTML = `<div class='pub-scroll'> <table class='tablediv' border='1' cellspacing='0' cellpadding='0'> <tr> <th>Year</th> <th>Publication Count</th> </tr>`; Object.entries(statistics).sort(([yearA], [yearB]) => yearB - yearA).forEach(([year, count]) => { const displayCount = count === 0 ? 'NA' : count; tableHTML += ` <tr> <td>${year}</td> <td>${displayCount}</td> </tr> `; }); tableHTML += '</table></div>'; resultsContainer.innerHTML = tableHTML; } function displayLineChart(statistics) { var years = Object.keys(statistics); var counts = Object.values(statistics); var ctx = document.getElementById('publicationChart').getContext('2d'); // Destroy existing chart instance if it exists if (chart !== null) { chart.destroy(); } // Create a new chart instance chart = new Chart(ctx, { type: 'line', data: { labels: years, datasets: [{ label: 'Publication Counts', data: counts, fill: false, borderColor: 'rgba(75, 192, 192, 1)', tension: 0.1 }] }, options: { scales: { y: { beginAtZero: true } }, plugins: { legend: { display: true, position: 'top' } } } }); } function displayKeywordStats(keywords) { var resultsContainer = document.getElementById('keyword-stats'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://gynecology.blog/publication-trends/index/${key_replace}" target="_blank" title="${key} - yearwise publication trends">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var statistics = { "2014": 194, "2015": 209, "2016": 277, "2017": 285, "2018": 264, "2019": 309, "2020": 505, "2021": 531, "2022": 724, "2023": 1085, "2024": 497 }; var keywordsArray = ["Ectopic Pregnancy","\u03b2-hCG","Methotrexate","Neutrophil-to-Lymphocyte Ratio","Platelet Distribution Width","MicroRNAs","Predictive Markers","Blood Markers","Complete Blood Count","Tubal Ectopic Pregnancy"]; displayResults(statistics); displayLineChart(statistics); displayKeywordStats(keywordsArray); </script></p> <h4><b>Complete Blood Count Parameters and Ectopic Pregnancy</b></h4> <p><span style="font-weight: 400;">Another recent study has assessed the role of complete blood count (CBC) factors in predicting the outcomes of treatments for ectopic pregnancy. It analyzed the prognostic value of a variety of blood markers derived from CBC, which include platelet count (PLT), the distribution width of platelets (PDW), and the neutrophil-lymphocyte ratio (NLR).</span></p> <p><span style="font-weight: 400;">Results from a retrospective study of 434 patients who received methotrexate for ectopic pregnancy have shown the NLR to be strongly associated with the outcome of the treatment. In that regard, patients with higher NLR values on the first, fourth, and seventh days of the treatment proved to have a better chance to resolve their ectopic pregnancy without any surgical intervention.This would imply that NLR could be added as an adjunct or even replacement or for β-hCG as a marker for predicting the effectiveness of therapies. Although PDW and PLT counts were comparable between the two groups and showed no marked differences, the association of NLR with effective methotrexate treatment makes the parameters of CBC potentially useful instruments in the management of ectopic pregnancies.</span></p> <p><span style="font-weight: 400;">Another compared intrauterine healthy pregnancies with tubal ectopic pregnancies in women in terms of variations of CBC values. The authors showed that, whereas patients with ectopic pregnancies had a significantly reduced level of PDW compared with patients with healthy pregnancies, there was no difference between them in the platelet count or MPV. It should be mentioned that WBC and monocytic levels were significantly increased in the group of ectopic pregnancy. This would therefore mean that the pathophysiology of an ectopic pregnancy is associated with activated monocytes that could influence the tubal motility and control of the microenvironment.</span></p> <h4><b>Other Blood Markers: The Role of MicroRNAs</b></h4> <p><span style="font-weight: 400;">Recent studies have been able to identify microRNAs as potential biomarkers for the early diagnosis of ectopic pregnancy aside from the traditional blood markers, which include β-hCG and CBC characteristics. MicroRNAs are small non-coding RNA molecules that are known to involve the regulation of gene expression. They have shown promises in distinguishing ectopic pregnancies from spontaneous miscarriages and from viable intrauterine pregnancies.</span></p> <p><span style="font-weight: 400;">Some microRNAs, which have been indicated as participating in the development of the placenta, circulate within the blood and were shown to express differently in women with ectopic pregnancies. Conclusions drawn from such research tend to indicate that microRNAs may present another level of diagnostic specificity, as they may be used to detect ectopic pregnancies earlier and therefore reduce the risk of rupture of the tubes and other adverse consequences. Further research is needed to validate these markers and standardize their use in clinical practice.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Recent Publications on <b>“<a href="https://gynecology.blog/recent-publications/index/ectopic pregnancy" target="_blank" rel="noopener" title="ectopic pregnancy - yearwise publication list">ectopic pregnancy</a>”</b></h2> </div> </div> <div class="pb-main"><div class="article-scroll"><div id="results_recent" class="results"></div></div><div class="keywordsdiv" style="margin: 0px 15px;margin-top:20px;"> <div style="text-align:center;"><b>Find publications on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-papers"></span> </div></div></div><div class="inside-article"> <style> .pb-main{ border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .author-main { border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .publication-block { padding: 10px; margin-bottom: 10px; background-color: #f9f9f9; text-align: left; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .publication-block h3 { margin: 0 0 10px; color: #000!important; } .publication-block a { font-size: 16px !important; line-height: 1em; font-weight: 600; text-transform: none; color: #000; padding: 0px; } .publication-block a:hover{ color: #227cdc; text-decoration:underline; } .article-scroll { max-height: 445px; overflow-y: auto; overflow-x: hidden; } ::-webkit-scrollbar-track { -webkit-box-shadow: inset 0 0 6px rgba(0,0,0,0.3); background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar { width: 6px; background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar-thumb { background-color: #ababab; border-radius:30px; } .publication-block p { margin-bottom: .5em; font-size: 15px; color: #000; } h3 { font-size: 18px !important; margin-bottom: 20px; line-height: 1.2em; font-weight: 600; text-transform: none; } a { padding: 5px; color: #a71c49; } #keyword-papers{ margin-top: 20px; text-align: center; } </style> <script> function displayResults_recent(papers) { var resultsContainer = document.getElementById('results_recent'); if (!papers || papers.length === 0) { resultsContainer.innerHTML = '<p>No recent publications found.</p>'; return; } papers.forEach(paper => { var publicationBlock = document.createElement('div'); publicationBlock.className = 'publication-block'; var publicationHTML = ` <div style="margin-bottom: 10px;line-height: 24px;"><a href="${paper.url}" target="_blank" title="${paper.title}">${paper.title}</a></div> <p><strong>Issue Release:</strong> ${paper.publishedDate}</p> `; publicationBlock.innerHTML = publicationHTML; resultsContainer.appendChild(publicationBlock); }); } function displayKeywordPapers(keywords) { var resultsContainer = document.getElementById('keyword-papers'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://gynecology.blog/recent-publications/index/${key_replace}" target="_blank" title="${key} - publication list">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var recent_papers = [ { "title": "Cesarean Scar Pregnancy With Surgical and Conservative Managements: A Case Report.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947697", "publishedDate": "2024" }, { "title": "Interstitial heterotopic pregnancy after bilateral total salpingectomy in IVF patients: a case report and literature review.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38874193", "publishedDate": "2024" }, { "title": "Pretreatment with or without GnRH-agonist before frozen-thawed embryo transfer in patients with PCOS: a systematic review and meta-analysis.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38907340", "publishedDate": "2024" }, { "title": "Consequences of \\\\\\'medical exceptions\\\\\\' in restrictive abortion legislation: caesarean scar ectopic pregnancy and beyond.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38902017", "publishedDate": "2024" }, { "title": "Comparing the effectiveness of letrozole versus methotrexate for treatment of ectopic pregnancy: A randomized controlled trial.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38901084", "publishedDate": "2024" }, { "title": "Risk factors for tubal patency and their impact on pregnancy rate after partial salpingectomy and end-to-end anastomosis.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38899360", "publishedDate": "2024" }, { "title": "Obstetric outcomes of women with congenital uterine anomalies in the United States.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38866133", "publishedDate": "2024" }, { "title": "Single day 14 serum hCG values allow prediction of viable pregnancy and are significantly higher in frozen as compared to fresh single blastocyst transfer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38867095", "publishedDate": "2024" }, { "title": "Caesarean Scar Ectopic Pregnancy Requiring Hysterectomy.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38950879", "publishedDate": "2024" }, { "title": "A 20\u00a0year experience in the management of non-tubal ectopic pregnancies in a tertiary hospital - a retrospective review.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38956582", "publishedDate": "2024" }, { "title": "Interstitial pregnancy: A retrospective case series of surgically managed patients over a ten-year period.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38874312", "publishedDate": "2024" }, { "title": "In silico design and analysis of a multi-epitope vaccine against Chlamydia.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38889932", "publishedDate": "2024" }, { "title": "Isolated pulmonary artery choriocarcinoma masquerading as pulmonary embolism diagnosed by endovascular biopsy.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38881620", "publishedDate": "2024" }, { "title": "An Uncommon Encounter: Obstetric Management of a Bicornuate Bicollis Uterus With a Longitudinal Vaginal Septum.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38903298", "publishedDate": "2024" }, { "title": "Surgical Outcomes and Trends in Incidence of Ectopic Pregnancy.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38911310", "publishedDate": "2024" }, { "title": "Partial Molar Ectopic Pregnancy: A diagnostic challenge.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38688570", "publishedDate": "2024" }, { "title": "Ruptured Caesarean Scar Ectopic Pregnancy: A Rare Case of Obstetric Hemorrhage.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38826599", "publishedDate": "2024" }, { "title": "Letter to the editor for \\\\\\\"Hysteroscopic subchorionic injection of methotrexate followed by laparoscopic excision of the gestational sac for the management of cesarean scar ectopic pregnancy: an innovative dual approach of a challenging pathology\\\\\\\".", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38763470", "publishedDate": "2024" }, { "title": "Proposal for individual treatment by tubal occlusion factor based on the results of salpingoscopic salpingoplasty.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38839109", "publishedDate": "2024" }, { "title": "Screening of single nucleotide polymorphism in matrix metalloproteinase-2 (MMP2) and tetraspanin CD63 genes in Chlamydia trachomatis-infected tubal ectopic pregnancy patients.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38650387", "publishedDate": "2024" } ]; var keywordsArray = ["Ectopic Pregnancy","\u03b2-hCG","Methotrexate","Neutrophil-to-Lymphocyte Ratio","Platelet Distribution Width","MicroRNAs","Predictive Markers","Blood Markers","Complete Blood Count","Tubal Ectopic Pregnancy"]; displayResults_recent(recent_papers); displayKeywordPapers(keywordsArray); </script></p> <h4><b>The Predictive Power of Blood Markers in Methotrexate Treatment</b></h4> <p><span style="font-weight: 400;">The common non-surgical treatment of ectopic pregnancies in women is methotrexate, especially with lower β-hCG levels and stable vital signs and so on. Blood indicators like β-hCG and the CBC features also often predict the outcome of methotrexate medication.</span></p> <p><span style="font-weight: 400;">Research has always shown that the higher success rates of methotrexate treatment are found in correlation with lower baseline levels of β-hCG. Most criteria setting up for further treatment when using methotrexate include a β-hCG level less than 5000 IU/L. Patients whose levels stand below the cutoff point have better chances of succeeding with the treatment, but those whose levels are higher may have a higher chance of failure but may, nonetheless, be candidates for surgery.</span></p> <p><span style="font-weight: 400;">Besides, as shown earlier in the previous paragraphs, NLR has proven to be an up-and-coming marker predicting the success of methotrexate. A particularly critical component in managing ectopic pregnancy is the difference NLR can make between patients who could probably receive methotrexate and those needing surgery, especially in disadvantaged regions where surgical facilities are not as readily accessible.</span></p> <h4><b>Conclusion</b></h4> <p><span style="font-weight: 400;">Detection, management, and monitoring of ectopic pregnancies call for blood indicators. Techniques range from the widely applied hormone of β-hCG to newly discovered markers such as microRNAs and NLRs. These provide clinicians with information on the severity of the illness as well as on the likelihood of a favorable course. Prediction and follow-up of treatment courses require careful consideration of blood indicators. These, especially in the case of methotrexate therapy, have an impossible predictive value. As efforts aimed at newer biomarkers and advanced benefits from the existing ones continually advance, the care of such ectopic pregnancies will probably be even more precise and individualized, thereby improving outcomes for patients and the decrease in hazards involving this dangerous condition.</span></p> <p></p> <h4><b>References</b></h4> <ol> <li>Kanmaz, A.G., Inan, A.H., Beyan, E. and Budak, A., 2018. <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6191789/">Role of various complete blood count parameters in predicting the success of single-dose Methotrexate in treating ectopic pregnancy.</a> <i>Pakistan Journal of Medical Sciences</i>, <i>34</i>(5), p.1132.</li> <li>Eskicioğlu, F., Özdemir, A.T., Turan, G.A., Gür, E.B., Kasap, E. and Genç, M., 2014. <a href="https://journals.viamedica.pl/ginekologia_polska/article/view/45806">The efficacy of complete blood count parameters in the diagnosis of tubal ectopic pregnancy.</a> <i>Ginekologia Polska</i>, <i>85</i>(11).</li> <li>Fernandez, H., Capmas, P., Lucot, J.P., Resch, B., Panel, P., Bouyer, J. and GROG, 2013. <a href="https://academic.oup.com/humrep/article-abstract/28/5/1247/941834">Fertility after ectopic pregnancy: the DEMETER randomized trial.</a> <i>Human Reproduction</i>, <i>28</i>(5), pp.1247-1253.</li> <li>Jurkovic, D., Memtsa, M., Sawyer, E., Donaldson, A.N.A., Jamil, A., Schramm, K., Sana, Y., Otify, M., Farahani, L., Nunes, N. and Ambler, G., 2017. <a href="https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.17329">Single‐dose systemic methotrexate vs expectant management for treatment of tubal ectopic pregnancy: a placebo‐controlled randomized trial.</a></li> <li>Orozco, E.M., Sánchez-Durán, M.A., Bello-Muñoz, J.C., Sagalá, J., Carreras, E. and Roura, L.C., 2015. <a href="https://www.tandfonline.com/doi/abs/10.3109/14767058.2014.928857">ß-hCG and prediction of therapeutic success in ectopic pregnancies treated with methotrexate, results from a prospective observational study.</a> <i>The Journal of Maternal-Fetal & Neonatal Medicine</i>, <i>28</i>(6), pp.695-699.</li> <li>Vaswani, P.R., 2014. <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4190761/">Predictors of success of medical management of ectopic pregnancy in a tertiary care hospital in United Arab Emirates.</a> <i>Journal of clinical and diagnostic research: JCDR</i>, <i>8</i>(8), p.OC04.</li> <li>Brady, P.C., 2017. <a href="https://journals.lww.com/obgynsurvey/abstract/2017/10000/new_evidence_to_guide_ectopic_pregnancy_diagnosis.20.aspx">New evidence to guide ectopic pregnancy diagnosis and management.</a> <i>Obstetrical & gynecological survey</i>, <i>72</i>(10), pp.618-625.</li> </ol> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Top Experts on “<b style="color:#000;font-size:22px;">ectopic pregnancy</b>“</h2> </div> </div><div class="author-main"><div id="results_author"></div><div style="text-align: center;"><a class="register-button" href="https://gynecology.blog/expert-search" target="_blank" rel="noopener">Find experts on any field</a></div></div><div class="inside-article" style="background: none;border: none;box-shadow: none;margin-top: -70px;"> <style> .author-block { padding: 15px; 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", "email": "s.khoo@uq.edu.au", "slug_tail": "s-khoo" } }; //console.log(authors_data); displayResults_author(authors_data); var keywordsArray = ["Ectopic Pregnancy","\u03b2-hCG","Methotrexate","Neutrophil-to-Lymphocyte Ratio","Platelet Distribution Width","MicroRNAs","Predictive Markers","Blood Markers","Complete Blood Count","Tubal Ectopic Pregnancy"]; displayKeywordAuthors(keywordsArray); </script></p> </div> <footer class="entry-meta" aria-label="Entry meta"> <span class="cat-links"><span class="gp-icon icon-categories"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M0 112c0-26.51 21.49-48 48-48h110.014a48 48 0 0143.592 27.907l12.349 26.791A16 16 0 00228.486 128H464c26.51 0 48 21.49 48 48v224c0 26.51-21.49 48-48 48H48c-26.51 0-48-21.49-48-48V112z" /></svg></span><span class="screen-reader-text">Categories </span><a href="https://gynecology.blog/archive/category/ectopic-pregnancy/" rel="category tag">Ectopic 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