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Data Space: <a href="http://dbpedia.org">dbpedia.org</a> </div> </div> </div> <div class="row pt-2"> <div class="col-xs-9 col-sm-10"> Melanin (/ˈmɛlənɪn/; from Greek: μέλας, romanized: melas, lit. 'black, dark') is a broad term for a group of natural pigments found in most organisms. Eumelanin is produced through a multistage chemical process known as melanogenesis, where the oxidation of the amino acid tyrosine is followed by polymerization. The melanin pigments are produced in a specialized group of cells known as melanocytes. Functionally, eumelanin serves as protection against UV radiation. Melanin (neuromelanin) functions as the catalyst of all cellular functions within an organism. </div> <div class="col-xs-3 col-sm-2"> <a href="#" class="thumbnail"> <img src="http://commons.wikimedia.org/wiki/Special:FilePath/Eumelanine.svg?width=300" alt="thumbnail" class="img-fluid" /> </a> </div> </div> </div> </section>   <section> <div class="container-xl"> <div class="row"> <div class="table-responsive"> <table class="table table-hover table-sm table-light"> <thead> <tr> <th class="col-xs-3 ">Property</th> <th class="col-xs-9 px-3">Value</th> </tr> </thead> <tbody> <tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/abstract">dbo:abstract</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">La melanina és un component present en plantes, animals i protists, on actua principalment com un pigment. Els pigments són derivats de l'aminoàcid tirosina. Moltes de les melanines són sals insolubles i mostren afinitat amb l'aigua. La forma més comuna de melanina biològica és l'eumelanina, un polímer d'àcid carboxílic dihidroxindol de color marró–negre i les seves formes reduïdes. Una altra forma comuna de la melanina és la feomelanina, unitats del polímer de benzotiazina de color vermell–marró responsables del cabell pèl-roig i les pigues. La presència de melanina en el regne dels bacteris és un tema de debat actual en el camp de la recerca. La producció creixent de melanina en la pell humana s'anomena melanogènesi. Està estimulada pels danys del DNA produïts per les radiacions ultraviolades, que condueix a un desenvolupament retardat del bronzejat. Aquest bronzejat basat a la melanogènesi tarda més temps en desenvolupar-se però, en canvi, és de més durada. Les propietats fotoquímiques de la melanina fan que sigui un excel·lent fotoprotector. Absorbeix les radiacions ultraviolades que produeixen danys i transforma l'energia en quantitats inofensives de calor a través del procés anomenat “conversió ultraràpida interna”. Aquesta propietat permet a la melanina dissipar més del 99,9% de les radiacions UV absorbides com a calor i això manté la generació de radicals lliures en un mínim. Això prevé dels danys indirectes de l'ADN, responsables de la formació del melanoma maligne. (ca)</li> <li style="display:none;">Melanin je označení pro hnědý až černý pigment, který se vyskytuje v tělech rostlin, živočichů i prvoků. Z chemického hlediska je odvozen z aminokyselin tyrosinu či tryptofanu, jež jsou oxidovány a zpolymerovány. Nejběžnější formou je hnědočerný polymer eumelanin. Další běžná forma je červenohnědý polymer feomelanin, který je zodpovědný za zrzavé vlasy a pihy. Oba mají mírně odlišnou chemickou strukturu. (cs)</li> <li style="display:none;">الميلانين هي مادة صبغية بروتينية تُفرز من قبل خلايا تدعى الخلايا الطلائية وتكون في جلد الإنسان وكذلك في بصيلات الشعر وغيرها. وهو مصطلح واسع لمجموعة من الصبغات الطبيعية الموجودة في معظم الكائنات الحية (العنكبوتيات من المجموعات القليلة التي لم يتم الكشف عنه فيها). ويتم إنتاج الميلانين عن طريق أكسدة الحمض الأميني التيروسين، تليها البلمرة. يتم إنتاج الصبغة في مجموعة متخصصة من الخلايا المعروفة باسم الخلايا الميلانية. يبدأ إنتاج الميلانين في الجلد بعد التعرض للأشعة فوق البنفسجية، مما يسبب اسمرار الجلد بشكل واضح. يعتبر الميلانين ممتص فعال للضوء، والصبغة قادرة على تبديد أكثر من 99.9٪ من الأشعة فوق البنفسجية الممتصة. وبسبب هذه الخاصية، يعتقد أنَّ الميلانين يحمي خلايا الجلد من أضرار الأشعة ما فوق البنفسجية، وبالتالي يحد من خطر الإصابة بالسرطان. وعلاوة على ذلك، على الرغم من أنَّ التعرض للأشعة فوق البنفسجية يرتبط بزيادة خطر الإصابة بسرطان الجلد الخبيث -سرطان الخلايا الميلانية- فقد أظهرت الدراسات وجود معدلات أقل للإصابة بسرطان الجلد في الأشخاص الذين لديهم تركيز أكبر من الميلانين، أي لون بشرة أكثر قتامة. ومع ذلك، لا تزال البحوث جارية لتوضيح العلاقة بين تصبُّغ الجلد والحماية بفعل الضوء. (ar)</li> <li style="display:none;">Η μελανίνη είναι μια οικογένεια χρωστικών που παράγονται από μια μεγάλη ποικιλία οργανισμών. Η μελανίνη παράγεται από το αμινοξύ τυροσίνη. Η μελανίνη είναι και υπάρχουν τρεις βασικοί τύποι, η ευμελανίνη, η φαιομελανίνη και η νευρομελανίνη. * Παράγεται σε εξειδικευμένα κύτταρα της επιδερμίδας, τα . Τα μελανινοκύτταρα βρίσκονται ανάμεσα στα κύτταρα της βασικής στιβάδας του δέρματος και τα τριχοθυλάκια (τις ρίζες των τριχών), καθώς και της ίριδας. Προέρχονται από κύτταρα της νευρικής ακρολοφίας, κάτι που εξηγεί τόσο το σχήμα, όσο και την ιδιαίτερη λειτουργία τους: * Έχουν στρογγυλά κυτταρικά σώματα, από όπου ξεκινούν μακριές, ακανόνιστες αποφυάδες (όπως και στα νευρικά κύτταρα). * Παράγουν την ευμελανίνη, μια έντονα καστανόχρωμη χρωστική, στην οποία οφείλεται το σκούρο χρώμα του δέρματος και των τριχών (εκκριτική λειτουργία, όπως και τα νευρικά κύτταρα). Η χρωστική που βρίσκεται στις κόκκινες τρίχες αποκαλείται φαιομελανίνη. Ο συνδυασμός της ποσότητας των ειδών μελανίνης καθορίζει και το χρώμα της ίριδας. * Οι αποφυάδες των μελανινοκυττάρων διακλαδίζονται μέσα στην επιδερμίδα προχωρώντας ανάμεσα στη βασική και την ακανθωτή στιβάδα, και καταλήγουν σε εγκολπώσεις των κυττάρων τως δύο αυτών στιβάδων (όπως αντίστοιχα καταλήγει ο νευράξονας των νευρικών κυττάρων στη νευρομυϊκή σύναψη). Απαραίτητο για την παραγωγή της μελανίνης είναι το αμινοξύ τυροσίνη. Για την παραγωγή της φαιομελανίνης (μελανίνης που απαντάται στις κόκκινες τρίχες) χρησιμοποιείται ως δομικό στοιχείο το αμινοξύ κυστεΐνη. Η μετατροπή της τυροσίνης σε μελανίνη καταλύεται από το ένζυμο τυροσινάση. Η τυροσινάση μεταφέρεται στον αυλό του ενδοπλασματικού δικτύου των μελανινοκυττάρων και συσσωρεύεται σε κυστίδια. Σε περίπτωση που δεν παράγεται η μελανίνη εξαιτίας της έλλειψης κάποιων ενζύμων, το άτομο πάσχει από αλφισμό. Από αυτό το σημείο και μετά διακρίνονται τέσσερα στάδια, που οδηγούν στο τελικό προϊόν, το ώριμο κοκκίο μελανίνης: * Στάδιο 1: Το κυστίδιο περιβάλλεται από μεμβράνη και ξεκινά η δράση της τυροσινάσης. * Στάδιο 2: Το κυστίδιο (μελανόσωμα) εμφανίζει στο εσωτερικό του παράλληλα νημάτια πάνω στα οποία εναποτίθεται η μελανίνη. * Στάδιο 3: Η αυξημένη παραγωγή μελανίνης εμποδίζει τη διάκριση δομικών λεπτομερειών μέσα στο κυστίδιο. * Στάδιο 4: Το ώριμο κοκκίο μελανίνης έχει ολοκληρωθεί & η μελανίνη γεμίζει τελείως το κυστίδιο. Τα ώριμα κοκκία μελανίνης μεταναστεύουν μέσα στις κυτταροπλασματικές αποφυάδες των μελανινοκυττάρων και μεταφέρονται στα κύτταρα της βασικής και ακανθωτής στιβάδας. Τέλος, τα ώριμα κοκκία μελανίνης αποθηκεύονται στα επιθηλιακά κύτταρα της επιδερμίδας. Στις επιφανειακότερες στιβάδες επιθηλιακών κυττάρων η μελανίνη εξαφανίζεται. Το χρώμα του δέρματος οφείλεται σε αρκετούς παράγοντες, οι σημαντικότεροι από τους οποίους είναι: * Η περιεκτικότητά του σε μελανίνη και . * Ο αριθμός των αγγείων στο χόριο. * Το χρώμα του αίματος που ρέει σε αυτά. * Τα μελανινοκύτταρα δεν κατανέμονται τυχαία μεταξύ των κερατινοκυττάρων, αλλά βάσει κάποιου προτύπου κατανομής (αναλογία μελανινοκυττάρων προς κερατινοκύτταρα σε κάθε περιοχή του σώματος). Υπάρχουν 1000 έως 2000 μελανινοκύτταρα ανά τετραγωνικό χιλιοστό. Η διαφορά στο χρώμα του δέρματος οφείλεται κυρίως σε διαφορές στον αριθμό των κοκκίων μελανίνης στα κερατινοκύτταρα. Το σκούρο χρώμα του δέρματος μετά από έκθεση στην υπεριώδη ηλιακή ακτινοβολία (μήκος κύματος 290-320 nm) είναι το αποτέλεσμα του ότι 1) η προϋπάρχουσα μελανίνη γίνεται πιο σκούρη και μεταφέρεται γρηγορότερα στα μελανινοκύτταρα 2) ο ρυθμός σύνθεσης μελανίνης στα μελανινοκύτταρα. Ο ρυθμός παραγωγής της μελανίνης ελέγχεται από τη μελανοτρόπο ορμόνη, που εκκρίνεται από την υπόφυση. Διαταραχές στην παραγωγή της μελανίνης σε μικρότερη ή μεγαλύτερη έκταση οδηγούν κατά περίπτωση σε σχηματισμό σκούρων ή ανοιχτόχρωμων κηλίδων στην επιφάνεια του δέρματος. (el)</li> <li style="display:none;">Melanine (von altgriechisch μέλας mélas „schwarz“) sind in der belebten Natur weit verbreitete dunkelbraune bis schwarze oder gelbliche bis rötliche Pigmente. Sie bewirken die Färbung der Haut, Haare, Federn und Augen. Chemisch handelt es sich um Copolymere mit Indolverbindungen als Untereinheiten. Sie kommen in Wirbeltieren und Insekten, als Farbstoff in der Tinte von Tintenfischen (siehe Sepia) und auch in Mikroorganismen und Pflanzen vor. Melanine entstehen durch die enzymatische Oxidation des Tyrosins (enzymatische Bräunung). Gebildet wird Melanin bei Wirbeltieren in den Melanozyten der Haut sowie in der Aderhaut und Iris des Auges. Beim Menschen und anderen Primaten kommt Neuromelanin, dessen dortige Funktion unklar ist, in der Substantia nigra des Gehirns vor. (de)</li> <li style="display:none;">Melanino estas tipo de kemiaĵo kiu troviĝas en plantoj, animaloj kaj protistoj, kiuj uzis ĝin kiel pigmenton. La plej abunda formo de biologia melanino estas la bruna-nigra eŭmelanino. Alia abunda formo estas feomelanino, kiu estas ruĝa-bruna kaj estas la plejparta kaŭzo de lentugoj. Oni ankoraŭ ne scias ĉu melanino vere ĉeestas arkeojn kaj bakteriojn. La rapidiga produkto de melanino en la haŭto de homoj nomiĝas melanogenezo (melaninkreado). Ĝi okazas pro la difekto de DNA pro UVB-radioj, kaj kaŭzas . Melanino defendas kontraŭ UV-radioj kaj ŝanĝas la energion al sendanĝera varmo. (eo)</li> <li style="display:none;">La melanina es un pigmento que se halla en la mayor parte de los seres vivos. En los animales el pigmento deriva del aminoácido tirosina. La forma más común de melanina es la eumelanina, un polímero negro-marrón de ácidos carboxílicos de dihidroxiindol y sus formas reducidas. Existen cinco tipos básicos de melanina: eumelanina, feomelanina, neuromelanina, alomelanina y piomelanina. (es)</li> <li style="display:none;">Melanina izeneko zelulek ekoizten duten pigmentua da, kolore ilunekoa, ilean, erretinan eta larruazalean, besteak beste, dagoena. Gizakiarengan ez ezik, animalia gehienetan ere badago (ornodun zein ornogabeengan). Melanina pigmentu fotobabeslea da, eguzkiaren izpi ultramoreen kalteak ekiditen dituena (izpi horiek mutagenoak baitira, eta melanomak sortzen dituzte), Melaninak izpi ultramore kaltegarriak xurgatzen ditu. Melanina gutxi dutenek (albinoek, larruazal zuriaren pertsonek eta zaharrek -melaninaren kopurua adina aurrera joan ahala gutxitzen baita-) aukera gehiago dute melanoma gaiztoak garatzeko. Melanina sortzeko prozesuari deritzo, eta izpi ultramoreek eragiten dute. Egitura kimikoari dagokionez, melanina tirosina aminoazidotik dator. Melaninaren gabezia albinismo izeneko gaitzarekin lotuta dago. Melanina ugaria da larruazal iluneko gizabanakoengan. Izpi ultramoreez gain, zenbait hormonak ere melanogenesia areagotzen dute (hipofisiak, esaterako, MSH -- izeneko hormona jariatzen du, melanozitoen jarduera bizkortzen duena). (eu)</li> <li>Melanin (/ˈmɛlənɪn/; from Greek: μέλας, romanized: melas, lit. 'black, dark') is a broad term for a group of natural pigments found in most organisms. Eumelanin is produced through a multistage chemical process known as melanogenesis, where the oxidation of the amino acid tyrosine is followed by polymerization. The melanin pigments are produced in a specialized group of cells known as melanocytes. Functionally, eumelanin serves as protection against UV radiation. Melanin (neuromelanin) functions as the catalyst of all cellular functions within an organism. There are five basic types of melanin: eumelanin, pheomelanin, neuromelanin, allomelanin and pyomelanin. The most common type is eumelanin, of which there are two types— brown eumelanin and black eumelanin. Pheomelanin, which is produced when melanocytes are malfunctioning due to derivation of the gene to its recessive format is a cysteine-derivative that contains polybenzothiazine portions that are largely responsible for the of red yellow tint given to some skin or hair colors. Neuromelanin is found in the brain. Research has been undertaken to investigate its efficacy in treating neurodegenerative disorders such as Parkinson's. Allomelanin and pyomelanin are two types of nitrogen-free melanin. In the human skin, melanogenesis is initiated by exposure to UV radiation, causing the skin to darken. Eumelanin is an effective absorbent of light; the pigment is able to dissipate over 99.9% of absorbed UV radiation. Because of this property, eumelanin is thought to protect skin cells from UVA and UVB radiation damage, reducing the risk of folate depletion and dermal degradation. Exposure to UV radiation is associated with increased risk of malignant melanoma, a cancer of melanocytes (melanin cells). Studies have shown a lower incidence for skin cancer in individuals with more concentrated melanin, i.e. darker skin tone. (en)</li> <li style="display:none;">Ábhair datha dhúdhonna a thugann dathanna difriúla, idir buí is donn, do na súile, an craiceann, an ghruaig, na cleití is na lanna i gcuid mhaith veirteabrach, i dtiúchain dhifriúla. I láthair sna cealla a iompraíonn ábhair datha (meilineafóir) in amfaibiaigh, reiptílí is éisc, agus cealla seachtracha craicinn (meilinicítí) na mamach. I ndaoine, cosnaíonn siad an craiceann i gcoinne damáiste ón radaíocht ultraivialait i solas na Gréine. Braitheann an oiread díobh atá sa chraiceann ar fhachtóirí géiniteacha is comhshaoil. (ga)</li> <li style="display:none;">Melanin (bahasa Yunani: μέλας, hitam; pengucapan bahasa Inggris: [ˈmɛ lə nɪn] ) adalah istilah luas untuk sekelompok pigmen alami yang ditemukan di sebagian besar organisme. Eumelanin diproduksi melalui proses kimia bertingkat yang dikenal sebagai melanogenesis, di mana oksidasi asam amino tirosin diikuti oleh polimerisasi. Pigmen melanin diproduksi dalam kelompok sel khusus yang dikenal sebagai melanosit. Secara fungsional, eumelanin berfungsi sebagai perlindungan terhadap radiasi UV. Melanin (neuromelanin) berfungsi sebagai katalis dari semua fungsi seluler dalam suatu organisme. Ada lima tipe dasar melanin: eumelanin, pheomelanin, neuromelanin, allomelanin, dan pyomelanin. Jenis yang paling umum adalah eumelanin, yang terdiri dari dua jenis— eumelanin coklat dan eumelanin hitam. Pheomelanin, yang diproduksi ketika melanosit tidak berfungsi karena penurunan gen ke format resesifnya adalah turunan sistein yang mengandung bagian polibenzotiazin yang sebagian besar bertanggung jawab atas warna merah kuning yang diberikan pada beberapa warna kulit atau rambut. Neuromelanin ditemukan di otak. Penelitian telah dilakukan untuk menyelidiki kemanjurannya dalam mengobati gangguan neurodegeneratif seperti Parkinson. Allomelanin dan pyomelanin adalah dua jenis melanin bebas nitrogen. Pada kulit manusia, melanogenesis diawali oleh paparan radiasi UV yang menyebabkan kulit menjadi gelap. Eumelanin adalah penyerap cahaya yang efektif; pigmen mampu menghilangkan lebih dari 99,9% radiasi UV yang diserap. Karena sifat ini, eumelanin dianggap melindungi sel kulit dari kerusakan radiasi UVA dan UVB, mengurangi risiko penipisan folat dan degradasi kulit. Paparan radiasi UV dikaitkan dengan peningkatan risiko melanoma ganas, kanker melanosit (sel melanin). Penelitian telah menunjukkan insiden kanker kulit yang lebih rendah pada individu dengan melanin yang lebih pekat, yaitu warna kulit yang lebih gelap. (in)</li> <li style="display:none;">Le mot mélanine est un mot générique qui désigne de nombreux pigments biologiques foncés qui sont notamment responsables de la coloration des téguments dans le règne animal. Chez l'être humain, la couleur de la peau, des cheveux et des yeux dépendent principalement de son type et de sa concentration. De nombreux animaux en produisent également, dont les oiseaux (coloration des plumes) et certains protozoaires. On la retrouve aussi comme pigment chez les champignons (mycète) chez lesquels elle renforce la paroi cellulaire, y compris chez des champignons microscopiques pathogènes (ex. : Aspergillus fumigatus). Les mélanines biologiques sont des macromolécules produites pour la plupart par les mélanocytes, par addition ou condensation de monomères formés à partir de la tyrosine (eumélanine) ou de la tyrosine et de la cystéine (phéomélanine), avec le concours de l'enzyme tyrosinase. Une faible proportion de la mélanine, comme la neuromélanine de la substantia nigra du cerveau humain, n'est pas fabriquée dans les mélanocytes, mais provient probablement du métabolisme d’une amine simple comme la dopamine. Des mélanines artificielles existent : polyacétylènes, polyanilines, et polypyrroles de couleur noire ou brune, et leurs copolymères ; elles ont une application industrielle ou biotechnologique. Son rôle principal est la « protection pigmentaire » contre les radiations UV. Chez certains animaux, les mélanophores, chromatophores porteurs de mélanine, contribuent au camouflage ou signalent par leurs transformations l’émotion, le stress ou un changement de l’environnement (température, etc.). Chez certains invertébrés, les agents pathogènes sont encapsulés dans de la mélanine, qui contribuerait donc chez eux à la défense contre les infections. Il semble aussi que ses groupes carboxylate et puissent isoler du milieu certains éléments dommageables lorsqu’ils sont en excès, comme les métaux lourds. (fr)</li> <li style="display:none;">멜라닌(영어: melanin)은 여러 동물들의 피부나 눈 등의 조직에 존재하는 흑색 내지는 갈색 색소를 총칭한다. 주로 글로불린과 강한 결합을 이루는 으로 존재하고, 물에는 용해되지 않지만 알칼리 용액이나 진한 황산에는 녹는다. 멜라닌은 일정량 이상의 자외선을 차단하는 기능이 있어서 피부의 체온을 유지시켜주고 자외선으로부터 피부를 보호해 준다. 또한, 멜라닌의 양에 의해서 피부색이 결정된다. (ko)</li> <li style="display:none;">メラニン (melanin) は、ヒトを含む動物、植物、原生動物、また一部の菌類、真正細菌において形成される色素である。メラニン色素ともいう。 (ja)</li> <li style="display:none;">Melanine is een biologisch pigment in de huid dat uit het aminozuur tyrosine wordt gevormd door melanocyten in een proces genaamd melanogenese. Melanocyten zijn cellen die in de kiemlaag van de huid liggen en worden aangemaakt in de basale laag van de opperhuid. Ze produceren deze stof in organellen (melanosomen) onder invloed van uv-straling en enkele stoffen zoals het melanocyt-stimulerend hormoon, een hormoon dat aangemaakt wordt door de adenohypofyse bij zwangere vrouwen (zwangerschapsmasker), tijdens de embryonale periode, bij heel jonge kinderen en bij bepaalde aandoeningen zoals melasma. De melanocyten geven de melanosomen gevuld met melanine op een nog onbekende manier (september 2021) via hun dendrieten af aan omliggende keratinocyten. Nadat de melanine door de keratinocyten is opgenomen wordt het naar de bovenkant van de kern getransporteerd, waar het het genetisch materiaal (gedeeltelijk) beschermt tegen uv-straling. Dit voorkomt mutaties en eventueel kanker. Toch is een passende hoeveelheid uv-licht van groot belang voor de mens omdat in de huid, dankzij uv-straling, vitamine D wordt aangemaakt. Melaninepigmenten zijn complexe structuren waaraan allerlei antioxidanten verbonden kunnen zitten, zoals bètacaroteen en co-enzym Q10. Er worden minstens drie verschillende typen gevormd: de geelbruine eumelaninen, de meer roodachtige feomelaninen waarin ook zwavelbevattende stoffen gecomplexeerd zitten, en de glansrijke rode die ook zwavel bevatten. Het aminozuur tyrosine wordt door het lichaam voor veel meer dan alleen melaninesynthese gebruikt en kan aldus gemakkelijk tekortschieten in de melaninevorming. Melanine is samen met slijm het voornaamste ingrediënt in inktvisseninkt. Melanine moet niet verward worden met melamine, een organische base en bestanddeel van kunstharsen, of met melatonine, een hormoon dat bij mensen in de epifyse (pijnappelklier) geproduceerd wordt en onder andere invloed heeft op het slaapritme. (nl)</li> <li style="display:none;">La melanina, o più propriamente le melanine, dal greco antico μέλας (mèlas = nero), sono pigmenti neri, bruni o rossastri. In alcune persone sono presenti in basse quantità mentre in altri in quantità più elevate, a seconda di fattori genetici e dell'esposizione ai raggi ultravioletti (UV). La quantità di melanina presente determina la colorazione più o meno scura della cute. (it)</li> <li style="display:none;">Melaniny – grupa pigmentów odpowiadających za pigmentację organizmów. U ludzi występują głównie w skórze, we włosach, a także w naczyniówce, powodując, że promienie świetlne mogą padać do wnętrza oka tylko przez źrenicę. Melaniny skóry i włosów powstają pod wpływem enzymu tyrozynazy w procesie enzymatycznym melanogenezy, do której silnie pobudza promieniowanie UV. Melaniny w skórze chronią jej głębsze warstwy przed szkodliwym działaniem promieni ultrafioletowych, które wchodzą w skład promieniowania słonecznego. Pod wpływem tych promieni ilość melanin się zwiększa, powodując przejściową zmianę zabarwienia skóry (opaleniznę). Od liczby i rodzaju cząsteczek melanin w cebulce włosa zależy jego kolor. U blondynów zawartość tych składników jest niska, a cząsteczki mają spiralną strukturę. Noworodki rasy białej nie mają w tęczówce melanin, dlatego ich oczy są niebieskie. Melaniny w tęczówce są wytwarzane później. U innych ras człowieka melaniny pojawiają się w tęczówce jeszcze przed narodzeniem. Zaburzenia w biosyntezie melanin powodują występowanie albinizmu, natomiast ich podwyższony poziom wywołuje melanizm[niewiarygodne źródło?]. Wśród melanin wyróżnia się m.in. eumelaninę, feomelaninę i [niewiarygodne źródło?]. Eumelanina jest barwnikiem czarnobrązowym[niewiarygodne źródło?], feomelanina jest pigmentem o zabarwieniu żółtoczerwonym[niewiarygodne źródło?]. Neuromelanina jest melaniną powstałą z dopaminy. (pl)</li> <li style="display:none;">Melaniner är en grupp av svarta, bruna och röda färgpigment som finns hos både växter, djur och protister. Huruvida även arkéer och bakterier har melanin är omtvistat. Hos växter och svampar stimuleras bildandet av melanin när organismen utsätts för skada. Människan och andra djur har särskilda celler som ansvarar för produktionen av melanin, melanocyter. Särskilt många melanocyter finns i överhuden, där melaninet har som funktion att absorbera en del av de skadliga strålarna från solen. Melaninerna färgar därmed huden brun, och mängderna melanin i huden ökar vid solbränna. Även hårets och ögats regnbågshinnas färg kommer från melanin. De flesta melaniner är polymerer, och bildas med hjälp av enzymet tyrosinas från aminosyran tyrosin. Kemiskt består melaniner av , , eller polymerer som är blandformer därav. Den vanligaste formen av biologiskt melanin är en polymer uppbyggd av monomererna indolequinon och/eller dihydroxyindol-karboxylsyra. (sv)</li> <li style="display:none;">Меланіни (від грец. μελας — «чорний») — клас органічних сполук, знайдених у рослинах, тваринах, найпростіших і бактеріях, де вони переважно виконують роль пігментів. (uk)</li> <li style="display:none;">Melanina é a denominação genérica de uma classe de compostos poliméricos derivados da tirosina, que é existente nos reinos Animal, Planta e Protista e cuja principal função é a pigmentação e proteção contra a radiação solar. É a melanina que, por exemplo, confere pigmentação à pele,aos olhos e aos cabelos dos mamíferos. A falta de melanina dá origem a uma condição denominada albinismo. A pele é composta por três camadas: a epiderme (camada superficial), a derme (camada intermediária) e a hipoderme (a camada mais profunda).A pele faz o pigmento melanina a cada 48 horas. A produção de melanina é feita pelos melanócitos ou melanoblastos, células da camada basal da epiderme que mantêm contacto com os queratinócitos por intermédio de projeções citoplasmáticas. Esses prolongamentos é que permitem que os pigmentos melânicos produzidos se depositem nos queratinócitos. (pt)</li> <li style="display:none;">Меланин (др.-греч. μέλας, родительный падеж μέλανος — чёрный) — высокомолекулярные пигменты , которые имеют нерегулярную структуру и сложный химический состав. В зависимости от химического строения их подразделяют на: эумеланины, феомеланины и алломеланины. Меланины содержатся в коже, волосах, радужной оболочке глаза, секретируемых чернилах головоногих и т. п. Меланины не обязательно находятся в покровах; например, у человека много меланинов обнаруживается во внутреннем ухе и некоторых отделах мозга. Меланин в кожных покровах позвоночных вырабатывается специализированными клетками — меланоцитами. Миграцию меланина в организме обеспечивают макрофаги-меланофоры, которые из-за отсутствия тирозиназы не способны к синтезу меланина. (ru)</li> <li style="display:none;">黑色素是生物色素，是酪氨酸經過一連串化學反應所形成，動物、植物與原生生物都有這種色素。黑色素通常是以聚合的方式存在。在黑色素细胞中，酪氨酸经酪氨酸酶作用，羟化生成多巴，后者经氧化、脱羧等反应转变成吲哚醌，最后吲哚醌聚合为黑色素。先天性酪氨酸酶缺乏的病人，因為不能合成黑色素，患者皮膚毛髮等發白，稱為白化病。白化病患者對陽光敏感，易患皮膚癌。 (zh)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/iupacName">dbo:iupacName</a> </td><td class="col-10 text-break"><ul> <li>3,8-Dimethyl-2,7-dihydrobenzo[1,2,3-cd:4,5,6-c′d′]diindole-4,5,9,10-tetrone (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/thumbnail">dbo:thumbnail</a> </td><td class="col-10 text-break"><ul> <li><a class="uri" rel="dbo:thumbnail" resource="http://commons.wikimedia.org/wiki/Special:FilePath/Eumelanine.svg?width=300" href="http://commons.wikimedia.org/wiki/Special:FilePath/Eumelanine.svg?width=300">wiki-commons:Special:FilePath/Eumelanine.svg?width=300</a></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" 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class="col-10 text-break"><ul> <li style="display:none;">Melanin je označení pro hnědý až černý pigment, který se vyskytuje v tělech rostlin, živočichů i prvoků. Z chemického hlediska je odvozen z aminokyselin tyrosinu či tryptofanu, jež jsou oxidovány a zpolymerovány. Nejběžnější formou je hnědočerný polymer eumelanin. Další běžná forma je červenohnědý polymer feomelanin, který je zodpovědný za zrzavé vlasy a pihy. Oba mají mírně odlišnou chemickou strukturu. (cs)</li> <li style="display:none;">Melanine (von altgriechisch μέλας mélas „schwarz“) sind in der belebten Natur weit verbreitete dunkelbraune bis schwarze oder gelbliche bis rötliche Pigmente. Sie bewirken die Färbung der Haut, Haare, Federn und Augen. Chemisch handelt es sich um Copolymere mit Indolverbindungen als Untereinheiten. Sie kommen in Wirbeltieren und Insekten, als Farbstoff in der Tinte von Tintenfischen (siehe Sepia) und auch in Mikroorganismen und Pflanzen vor. Melanine entstehen durch die enzymatische Oxidation des Tyrosins (enzymatische Bräunung). Gebildet wird Melanin bei Wirbeltieren in den Melanozyten der Haut sowie in der Aderhaut und Iris des Auges. Beim Menschen und anderen Primaten kommt Neuromelanin, dessen dortige Funktion unklar ist, in der Substantia nigra des Gehirns vor. (de)</li> <li style="display:none;">Melanino estas tipo de kemiaĵo kiu troviĝas en plantoj, animaloj kaj protistoj, kiuj uzis ĝin kiel pigmenton. La plej abunda formo de biologia melanino estas la bruna-nigra eŭmelanino. Alia abunda formo estas feomelanino, kiu estas ruĝa-bruna kaj estas la plejparta kaŭzo de lentugoj. Oni ankoraŭ ne scias ĉu melanino vere ĉeestas arkeojn kaj bakteriojn. La rapidiga produkto de melanino en la haŭto de homoj nomiĝas melanogenezo (melaninkreado). Ĝi okazas pro la difekto de DNA pro UVB-radioj, kaj kaŭzas . Melanino defendas kontraŭ UV-radioj kaj ŝanĝas la energion al sendanĝera varmo. (eo)</li> <li style="display:none;">La melanina es un pigmento que se halla en la mayor parte de los seres vivos. En los animales el pigmento deriva del aminoácido tirosina. La forma más común de melanina es la eumelanina, un polímero negro-marrón de ácidos carboxílicos de dihidroxiindol y sus formas reducidas. Existen cinco tipos básicos de melanina: eumelanina, feomelanina, neuromelanina, alomelanina y piomelanina. (es)</li> <li style="display:none;">Ábhair datha dhúdhonna a thugann dathanna difriúla, idir buí is donn, do na súile, an craiceann, an ghruaig, na cleití is na lanna i gcuid mhaith veirteabrach, i dtiúchain dhifriúla. I láthair sna cealla a iompraíonn ábhair datha (meilineafóir) in amfaibiaigh, reiptílí is éisc, agus cealla seachtracha craicinn (meilinicítí) na mamach. I ndaoine, cosnaíonn siad an craiceann i gcoinne damáiste ón radaíocht ultraivialait i solas na Gréine. Braitheann an oiread díobh atá sa chraiceann ar fhachtóirí géiniteacha is comhshaoil. (ga)</li> <li style="display:none;">멜라닌(영어: melanin)은 여러 동물들의 피부나 눈 등의 조직에 존재하는 흑색 내지는 갈색 색소를 총칭한다. 주로 글로불린과 강한 결합을 이루는 으로 존재하고, 물에는 용해되지 않지만 알칼리 용액이나 진한 황산에는 녹는다. 멜라닌은 일정량 이상의 자외선을 차단하는 기능이 있어서 피부의 체온을 유지시켜주고 자외선으로부터 피부를 보호해 준다. 또한, 멜라닌의 양에 의해서 피부색이 결정된다. (ko)</li> <li style="display:none;">メラニン (melanin) は、ヒトを含む動物、植物、原生動物、また一部の菌類、真正細菌において形成される色素である。メラニン色素ともいう。 (ja)</li> <li style="display:none;">La melanina, o più propriamente le melanine, dal greco antico μέλας (mèlas = nero), sono pigmenti neri, bruni o rossastri. In alcune persone sono presenti in basse quantità mentre in altri in quantità più elevate, a seconda di fattori genetici e dell'esposizione ai raggi ultravioletti (UV). La quantità di melanina presente determina la colorazione più o meno scura della cute. (it)</li> <li style="display:none;">Меланіни (від грец. μελας — «чорний») — клас органічних сполук, знайдених у рослинах, тваринах, найпростіших і бактеріях, де вони переважно виконують роль пігментів. (uk)</li> <li style="display:none;">黑色素是生物色素，是酪氨酸經過一連串化學反應所形成，動物、植物與原生生物都有這種色素。黑色素通常是以聚合的方式存在。在黑色素细胞中，酪氨酸经酪氨酸酶作用，羟化生成多巴，后者经氧化、脱羧等反应转变成吲哚醌，最后吲哚醌聚合为黑色素。先天性酪氨酸酶缺乏的病人，因為不能合成黑色素，患者皮膚毛髮等發白，稱為白化病。白化病患者對陽光敏感，易患皮膚癌。 (zh)</li> <li style="display:none;">الميلانين هي مادة صبغية بروتينية تُفرز من قبل خلايا تدعى الخلايا الطلائية وتكون في جلد الإنسان وكذلك في بصيلات الشعر وغيرها. وهو مصطلح واسع لمجموعة من الصبغات الطبيعية الموجودة في معظم الكائنات الحية (العنكبوتيات من المجموعات القليلة التي لم يتم الكشف عنه فيها). ويتم إنتاج الميلانين عن طريق أكسدة الحمض الأميني التيروسين، تليها البلمرة. يتم إنتاج الصبغة في مجموعة متخصصة من الخلايا المعروفة باسم الخلايا الميلانية. (ar)</li> <li style="display:none;">La melanina és un component present en plantes, animals i protists, on actua principalment com un pigment. Els pigments són derivats de l'aminoàcid tirosina. Moltes de les melanines són sals insolubles i mostren afinitat amb l'aigua. La forma més comuna de melanina biològica és l'eumelanina, un polímer d'àcid carboxílic dihidroxindol de color marró–negre i les seves formes reduïdes. Una altra forma comuna de la melanina és la feomelanina, unitats del polímer de benzotiazina de color vermell–marró responsables del cabell pèl-roig i les pigues. La presència de melanina en el regne dels bacteris és un tema de debat actual en el camp de la recerca. La producció creixent de melanina en la pell humana s'anomena melanogènesi. Està estimulada pels danys del DNA produïts per les radiacions ultravio (ca)</li> <li style="display:none;">Η μελανίνη είναι μια οικογένεια χρωστικών που παράγονται από μια μεγάλη ποικιλία οργανισμών. Η μελανίνη παράγεται από το αμινοξύ τυροσίνη. Η μελανίνη είναι και υπάρχουν τρεις βασικοί τύποι, η ευμελανίνη, η φαιομελανίνη και η νευρομελανίνη. Από αυτό το σημείο και μετά διακρίνονται τέσσερα στάδια, που οδηγούν στο τελικό προϊόν, το ώριμο κοκκίο μελανίνης: Το χρώμα του δέρματος οφείλεται σε αρκετούς παράγοντες, οι σημαντικότεροι από τους οποίους είναι: (el)</li> <li style="display:none;">Melanina izeneko zelulek ekoizten duten pigmentua da, kolore ilunekoa, ilean, erretinan eta larruazalean, besteak beste, dagoena. Gizakiarengan ez ezik, animalia gehienetan ere badago (ornodun zein ornogabeengan). Melanina sortzeko prozesuari deritzo, eta izpi ultramoreek eragiten dute. Egitura kimikoari dagokionez, melanina tirosina aminoazidotik dator. Melaninaren gabezia albinismo izeneko gaitzarekin lotuta dago. Melanina ugaria da larruazal iluneko gizabanakoengan. (eu)</li> <li>Melanin (/ˈmɛlənɪn/; from Greek: μέλας, romanized: melas, lit. 'black, dark') is a broad term for a group of natural pigments found in most organisms. Eumelanin is produced through a multistage chemical process known as melanogenesis, where the oxidation of the amino acid tyrosine is followed by polymerization. The melanin pigments are produced in a specialized group of cells known as melanocytes. Functionally, eumelanin serves as protection against UV radiation. Melanin (neuromelanin) functions as the catalyst of all cellular functions within an organism. (en)</li> <li style="display:none;">Melanin (bahasa Yunani: μέλας, hitam; pengucapan bahasa Inggris: [ˈmɛ lə nɪn] ) adalah istilah luas untuk sekelompok pigmen alami yang ditemukan di sebagian besar organisme. Eumelanin diproduksi melalui proses kimia bertingkat yang dikenal sebagai melanogenesis, di mana oksidasi asam amino tirosin diikuti oleh polimerisasi. Pigmen melanin diproduksi dalam kelompok sel khusus yang dikenal sebagai melanosit. Secara fungsional, eumelanin berfungsi sebagai perlindungan terhadap radiasi UV. Melanin (neuromelanin) berfungsi sebagai katalis dari semua fungsi seluler dalam suatu organisme. (in)</li> <li style="display:none;">Le mot mélanine est un mot générique qui désigne de nombreux pigments biologiques foncés qui sont notamment responsables de la coloration des téguments dans le règne animal. Chez l'être humain, la couleur de la peau, des cheveux et des yeux dépendent principalement de son type et de sa concentration. De nombreux animaux en produisent également, dont les oiseaux (coloration des plumes) et certains protozoaires. (fr)</li> <li style="display:none;">Melaniny – grupa pigmentów odpowiadających za pigmentację organizmów. U ludzi występują głównie w skórze, we włosach, a także w naczyniówce, powodując, że promienie świetlne mogą padać do wnętrza oka tylko przez źrenicę. Wśród melanin wyróżnia się m.in. eumelaninę, feomelaninę i [niewiarygodne źródło?]. Eumelanina jest barwnikiem czarnobrązowym[niewiarygodne źródło?], feomelanina jest pigmentem o zabarwieniu żółtoczerwonym[niewiarygodne źródło?]. Neuromelanina jest melaniną powstałą z dopaminy. (pl)</li> <li style="display:none;">Melanine is een biologisch pigment in de huid dat uit het aminozuur tyrosine wordt gevormd door melanocyten in een proces genaamd melanogenese. Melanocyten zijn cellen die in de kiemlaag van de huid liggen en worden aangemaakt in de basale laag van de opperhuid. Ze produceren deze stof in organellen (melanosomen) onder invloed van uv-straling en enkele stoffen zoals het melanocyt-stimulerend hormoon, een hormoon dat aangemaakt wordt door de adenohypofyse bij zwangere vrouwen (zwangerschapsmasker), tijdens de embryonale periode, bij heel jonge kinderen en bij bepaalde aandoeningen zoals melasma. De melanocyten geven de melanosomen gevuld met melanine op een nog onbekende manier (september 2021) via hun dendrieten af aan omliggende keratinocyten. (nl)</li> <li style="display:none;">Melanina é a denominação genérica de uma classe de compostos poliméricos derivados da tirosina, que é existente nos reinos Animal, Planta e Protista e cuja principal função é a pigmentação e proteção contra a radiação solar. É a melanina que, por exemplo, confere pigmentação à pele,aos olhos e aos cabelos dos mamíferos. A falta de melanina dá origem a uma condição denominada albinismo. (pt)</li> <li style="display:none;">Melaniner är en grupp av svarta, bruna och röda färgpigment som finns hos både växter, djur och protister. Huruvida även arkéer och bakterier har melanin är omtvistat. Hos växter och svampar stimuleras bildandet av melanin när organismen utsätts för skada. Människan och andra djur har särskilda celler som ansvarar för produktionen av melanin, melanocyter. Särskilt många melanocyter finns i överhuden, där melaninet har som funktion att absorbera en del av de skadliga strålarna från solen. Melaninerna färgar därmed huden brun, och mängderna melanin i huden ökar vid solbränna. Även hårets och ögats regnbågshinnas färg kommer från melanin. (sv)</li> <li style="display:none;">Меланин (др.-греч. μέλας, родительный падеж μέλανος — чёрный) — высокомолекулярные пигменты , которые имеют нерегулярную структуру и сложный химический состав. В зависимости от химического строения их подразделяют на: эумеланины, феомеланины и алломеланины. Меланины содержатся в коже, волосах, радужной оболочке глаза, секретируемых чернилах головоногих и т. п. Меланины не обязательно находятся в покровах; например, у человека много меланинов обнаруживается во внутреннем ухе и некоторых отделах мозга. (ru)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://www.w3.org/2000/01/rdf-schema#label">rdfs:label</a> </td><td class="col-10 text-break"><ul> <li>Melanin (en)</li> <li style="display:none;">ميلانين (ar)</li> <li style="display:none;">Melanina (ca)</li> <li style="display:none;">Melanin (cs)</li> <li style="display:none;">Melanine (de)</li> <li style="display:none;">Μελανίνη (el)</li> <li style="display:none;">Melanino (eo)</li> <li style="display:none;">Melanina (es)</li> <li style="display:none;">Melanina (eu)</li> <li style="display:none;">Meilinin (ga)</li> <li style="display:none;">Melanin (in)</li> <li style="display:none;">Melanina (it)</li> <li style="display:none;">Mélanine (fr)</li> <li style="display:none;">멜라닌 (ko)</li> <li style="display:none;">メラニン (ja)</li> <li style="display:none;">Melanine (nl)</li> <li style="display:none;">Melaniny (pl)</li> <li style="display:none;">Melanina (pt)</li> <li style="display:none;">Melaniner (sv)</li> <li style="display:none;">Меланины (ru)</li> <li style="display:none;">黑色素 (zh)</li> <li style="display:none;">Меланіни (uk)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://www.w3.org/2002/07/owl#differentFrom">owl:differentFrom</a> </td><td class="col-10 text-break"><ul> <li><a class="uri" rel="owl:differentFrom" resource="http://dbpedia.org/resource/Melamine" href="http://dbpedia.org/resource/Melamine">dbr:Melamine</a></li> <li><a class="uri" rel="owl:differentFrom" resource="http://dbpedia.org/resource/Melatonin" href="http://dbpedia.org/resource/Melatonin">dbr:Melatonin</a></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://www.w3.org/2002/07/owl#sameAs">owl:sameAs</a> </td><td class="col-10 text-break"><ul> <li><a class="uri" rel="owl:sameAs" resource="http://rdf.freebase.com/ns/m.0db_x" href="http://rdf.freebase.com/ns/m.0db_x">freebase:Melanin</a></li> <li><a class="uri" rel="owl:sameAs" 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href="http://dbpedia.org/resource/Hyperpigmentation">dbr:Hyperpigmentation</a></li> </ul></td></tr><tr class="odd"><td class="col-2">is <a class="uri" href="http://dbpedia.org/property/knownFor">dbp:knownFor</a> of</td><td class="col-10 text-break"><ul> <li><a class="uri" rev="dbp:knownFor" resource="http://dbpedia.org/resource/Nyakim_Gatwech" href="http://dbpedia.org/resource/Nyakim_Gatwech">dbr:Nyakim_Gatwech</a></li> </ul></td></tr><tr class="even"><td class="col-2">is <a class="uri" href="http://www.w3.org/2000/01/rdf-schema#seeAlso">rdfs:seeAlso</a> of</td><td class="col-10 text-break"><ul> <li><a class="uri" rev="rdfs:seeAlso" resource="http://dbpedia.org/resource/Human_skin_color" href="http://dbpedia.org/resource/Human_skin_color">dbr:Human_skin_color</a></li> </ul></td></tr><tr class="odd"><td class="col-2">is <a class="uri" href="http://www.w3.org/2002/07/owl#differentFrom">owl:differentFrom</a> of</td><td class="col-10 text-break"><ul> <li><a class="uri" rev="owl:differentFrom" resource="http://dbpedia.org/resource/Melamine" href="http://dbpedia.org/resource/Melamine">dbr:Melamine</a></li> </ul></td></tr><tr class="even"><td class="col-2">is <a class="uri" href="http://xmlns.com/foaf/0.1/primaryTopic">foaf:primaryTopic</a> of</td><td class="col-10 text-break"><ul> <li><a class="uri" rev="foaf:primaryTopic" resource="http://en.wikipedia.org/wiki/Melanin" href="http://en.wikipedia.org/wiki/Melanin">wikipedia-en:Melanin</a></li> </ul></td></tr> </tbody> </table> </div> </div> </div> </section>   <section> <div class="container-xl"> <div class="text-center p-4 bg-light"> <a href="https://virtuoso.openlinksw.com/" title="OpenLink Virtuoso"><img class="powered_by" src="/statics/images/virt_power_no_border.png" alt="Powered by OpenLink Virtuoso"/></a>    <a href="http://linkeddata.org/"><img alt="This material is Open Knowledge" src="/statics/images/LoDLogo.gif"/></a>     <a href="http://dbpedia.org/sparql"><img alt="W3C Semantic Web 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