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class="product-label-list"><script id="variant-label-8456360984744-48455101415592" type="text/template"></script><div class="product-label-container"></div></span> </div> <div class="title-row" > <h1 class="title">In vivo pharmacokinetics screening</h1> </div> <div class="" > <div class="product-description rte cf"><div dir="ltr" data-mce-fragment="1"> <div spellcheck="false" class="input-box" data-mce-fragment="1"> <div class="cell-input editable disabled-input" role="combobox" id="waffle-rich-text-editor" dir="ltr" aria-autocomplete="list" aria-label="C12" tabindex="0" data-mce-fragment="1" data-mce-tabindex="0" contenteditable="false" docs-unhandledkeys="ctrl+shift+z,ctrl+y,ctrl+z" g_editable="true"> <p>As we realize the importance of speedy data delivery during drug discovery, we offer a PK screening service for our customers. As a frequently occurring screening, the data can be delivered within one week!</p> <p>The study formulations (small molecules) are dosed to study animals (mouse or rat) and plasma samples are collected and analyzed by UPLC/MS/MS. The assay requires a minimum of three compounds per batch.</p> <p>The assay is available as a stand-alone service or as part of integrated drug discovery projects at Symeres.</p> </div> </div> </div></div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Protocol</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p>Test concentrations: 1</p><p>Time points: 6</p><p>Replicates: 3</p><p></p><p>UPLC/MS/MS analysis</p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Deliverables</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p><span class="metafield-multi_line_text_field">Plasma concentrations, PK calculations (e.g., F, CL, Vd, Cmax, Tmax, AUC, t1/2)</span></p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Reporting</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p><span class="metafield-multi_line_text_field">Excel report</span></p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item"> <summary class="cc-accordion-item__title">Background</summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p>In in vivo DMPK studies, compounds are administered to rodents and samples collected over a pre-defined time period. The dosing regimen and sampling are designed according to the project needs and prior information available on the study compounds, and the concentration-time data can be summarized using non-compartmental analysis (NCA) or compartmental modelling. Several options are available for bioanalytics, and the methods are always optimized for the study compounds instead of using generic methods. Furthermore, when LC/HR-MS is used, the same data can be used later for metabolite identification and profiling.</p></div> </div> </details> </div> </div> </div> </div> <div class="detail product-column-right" data-cc-animate data-cc-animate-delay="0.2s"> <div class="product-form" data-ajax-add-to-cart="true" data-product-id="8456360984744" data-enable-history-state="true"> <div class="buy-buttons-row" > <form method="post" action="/cart/add" id="product-form-template--16460963283112__main-8456360984744" accept-charset="UTF-8" class="form product-purchase-form" enctype="multipart/form-data" data-product-id="8456360984744"><input type="hidden" name="form_type" value="product" /><input type="hidden" name="utf8" value="✓" /> <select name="id" class="original-selector hidden" aria-label="Options"> <option value="48455101415592" selected="selected" data-stock="">Default Title</option> </select> <div class="quantity-submit-row input-row "> <div class="quantity-submit-row__submit input-row"><button class="button button--large" type="submit" data-add-to-cart-text="Add to quote request">Add to quote request</button> </div> </div> <input type="hidden" name="product-id" value="8456360984744" /><input type="hidden" name="section-id" value="template--16460963283112__main" /></form> </div> <div class="lightish-spaced-row-above only-in-quickbuy"> <a class="more" href="/products/in-vivo-pharmacokinetics-screening"> <span class="beside-svg underline">More details</span> <span class="icon--small icon-natcol ltr-icon"> <span class="material-symbols-outlined"> chevron_right </span></span> </a> </div> </div> <script type="application/json" id="ProductJson-8456360984744">{"id":8456360984744,"title":"In vivo pharmacokinetics screening","handle":"in-vivo-pharmacokinetics-screening","description":"\u003cdiv dir=\"ltr\" data-mce-fragment=\"1\"\u003e\n\u003cdiv spellcheck=\"false\" class=\"input-box\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"cell-input editable disabled-input\" role=\"combobox\" id=\"waffle-rich-text-editor\" dir=\"ltr\" aria-autocomplete=\"list\" aria-label=\"C12\" tabindex=\"0\" data-mce-fragment=\"1\" data-mce-tabindex=\"0\" contenteditable=\"false\" docs-unhandledkeys=\"ctrl+shift+z,ctrl+y,ctrl+z\" g_editable=\"true\"\u003e\n\u003cp\u003eAs we realize the importance of speedy data delivery during drug discovery, we offer a PK screening service for our customers. As a frequently occurring screening, the data can be delivered within one week!\u003c\/p\u003e\n\u003cp\u003eThe study formulations (small molecules) are dosed to study animals (mouse or rat) and plasma samples are collected and analyzed by UPLC\/MS\/MS. 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As a frequently occurring screening, the data can be delivered within one week!\u003c\/p\u003e\n\u003cp\u003eThe study formulations (small molecules) are dosed to study animals (mouse or rat) and plasma samples are collected and analyzed by UPLC\/MS\/MS. 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The assay requires a minimum of three compounds per batch.\nThe assay is available as a stand-alone service or as part of integrated drug discovery projects at Symeres.\n\n\n","brand": { "@type": "Brand", "name": "Admescope" }, "offers": [{ "@type" : "Offer","availability" : "http://schema.org/InStock", "price" : 0.0, "priceCurrency" : "EUR", "url" : "https:\/\/admeshop.com\/products\/in-vivo-pharmacokinetics-screening?variant=48455101415592", "seller": { "@type": "Organization", "name": "Admeshop" } } ] } </script> </div><div id="shopify-section-template--16460963283112__recommendations" class="shopify-section section-product-recommendations"><div class="product-recommendations" data-section-id="template--16460963283112__recommendations" data-url="/recommendations/products?section_id=template--16460963283112__recommendations&limit=4&product_id=8456360984744" data-components="accordion,modal" data-cc-animate> </div> </div> </div> </main><div id="pagefooter">  <div 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