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(PDF) Impact of Kidney Allograft Vasculopathy on Delayed Graft Function

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transplantation","image":"https://attachments.academia-assets.com/46036932/thumbnails/1.jpg","inLanguage":"en","keywords":["Kidney diseases","Kidney transplantation","Treatment Outcome","Incidence","Risk factors","Allografts","Cadaver","Retrospective Studies","Risk Factors","Delayed graft function","Postoperative Complications"],"publication":"Jornal Brasileiro de Nefrologia","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/46036932/thumbnails/1.jpg","url":"https://www.academia.edu/12633672/Vasculopathy_in_the_kidney_allograft_at_time_of_transplantation_delays_recovery_of_graft_function_after_deceased_donor_kidney_transplantation"}</script><link rel="stylesheet" media="all" 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{"work":{"id":12633672,"created_at":"2015-05-27T10:55:27.679-07:00","from_world_paper_id":136921470,"updated_at":"2024-11-30T16:45:43.055-08:00","_data":{"ai_title_tag":"Impact of Kidney Allograft Vasculopathy on Delayed Graft Function","grobid_abstract":"Objective: The purpose of this study was to evaluate the impact of donor and recipient characteristics on duration of delayed graft function (DGF) and 1-year serum creatinine (SCr), as a surrogate endpoint for allograft survival. Methods: We reviewed 120 first cadaver kidney transplants carried out consecutively at our center to examine the effect on 1-year SCr of the presence and duration of DGF. Results: DGF rate was 68%, with a median duration of 12 days (range, 1-61). Forty-four (38%) patients presented DGF lasting 12 or more days (prolonged DGF group). Mean donor age was 43 ± 13 years, 37% had hypertension and in 59% the cause of brain death was cardiovascular accident. The mean cold ischemia time was 23 ± 5 hours. Twenty-seven (23%) donors were classified as expanded-criteria donors according to OPTN criteria. The mean recipient age was 51 ± 15 years. The recipients median time in dialysis was 43 months (range, 1-269) and 25% of them had panel reactive antibodies \u003e 0%. Patients with prolonged DGF presented higher 1-year SCr in comparison with patients without DGF (1.7 vs. 1.3 mg/dL, respectively, p = 0.03). In multivariate logistic regression analysis, the only significant factor contributing to the occurrence of prolonged DGF was the presence of vascular lesions in the kidney allograft at time of transplantation (HR 3.6, 95%","publication_date":"2014,,","publication_name":"Jornal Brasileiro de Nefrologia","grobid_abstract_attachment_id":"46036932"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Vasculopathy in the kidney allograft at time of transplantation delays recovery of graft function after deceased-donor kidney transplantation","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [31603377]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; 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class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="22118004" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22118004/Risk_Factors_and_Outcome_of_Delayed_Graft_Function_after_Cadaveric_Kidney_Transplantation_A_Report_from_the_Thai_Transplant_Registry">Risk Factors and Outcome of Delayed Graft Function after Cadaveric Kidney Transplantation: A Report from the Thai Transplant Registry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43438369" href="https://mahidol.academia.edu/AtipornIngsathit">Atiporn Ingsathit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplantation Proceedings, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Risk Factors and Outcome of Delayed Graft Function after Cadaveric Kidney Transplantation: A Report from the Thai Transplant Registry&quot;,&quot;attachmentId&quot;:42786516,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/22118004/Risk_Factors_and_Outcome_of_Delayed_Graft_Function_after_Cadaveric_Kidney_Transplantation_A_Report_from_the_Thai_Transplant_Registry&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22118004/Risk_Factors_and_Outcome_of_Delayed_Graft_Function_after_Cadaveric_Kidney_Transplantation_A_Report_from_the_Thai_Transplant_Registry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="69073690" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/69073690/Delayed_graft_function_allograft_and_patient_srvival_in_kidney_transplantation">Delayed graft function, allograft and patient srvival in kidney transplantation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="156361567" href="https://independent.academia.edu/Jalalzadeh">Mojgan Jalalzadeh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Arab journal of nephrology and transplantation, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Delayed Graft Function (DGF) is a common complication of renal transplants and the long-term relation between DGF and survival of patients and grafts is not well established. This is a historical cohort study of transplanted patients in Taleghani Hospital of Shahid Beheshti University in Iran between 1994 and 2010. Patients who required dialysis during the first week after transplantation were considered to have DGF. The patients&amp;#39; conditions were updated to determine existing graft function, graft loss or patients&amp;#39; death at one year and five years post transplantation in relation to the presence or absence of DGF. DGF complicated 67/385 transplants (17.4%). Causes included acute tubular necrosis (58.2%), accelerated rejection (29.9%), transplant renal artery thrombosis (9%) and renal vein thrombosis (3%). More kidneys in the DGF group were procured from cadaveric donors (6% versus 0.9%, P = 0.02). At hospital discharge, patients with DGF had significantly higher mean creatin...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Delayed graft function, allograft and patient srvival in kidney transplantation&quot;,&quot;attachmentId&quot;:79311197,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/69073690/Delayed_graft_function_allograft_and_patient_srvival_in_kidney_transplantation&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/69073690/Delayed_graft_function_allograft_and_patient_srvival_in_kidney_transplantation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="25909433" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25909433/Creatinine_Reduction_Ratio_on_Post_Transplant_Day_Two_as_Criterion_in_Defining_Delayed_Graft_Function">Creatinine Reduction Ratio on Post-Transplant Day Two as Criterion in Defining Delayed Graft Function</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49704018" href="https://humv.academia.edu/JulioCotorruelo">Julio Cotorruelo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Transplantation, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Creatinine Reduction Ratio on Post-Transplant Day Two as Criterion in Defining Delayed Graft Function&quot;,&quot;attachmentId&quot;:46272335,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/25909433/Creatinine_Reduction_Ratio_on_Post_Transplant_Day_Two_as_Criterion_in_Defining_Delayed_Graft_Function&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25909433/Creatinine_Reduction_Ratio_on_Post_Transplant_Day_Two_as_Criterion_in_Defining_Delayed_Graft_Function"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="51780644" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/51780644/Long_term_effects_of_delayed_graft_function_duration_on_function_and_survival_of_deceased_donor_kidney_transplants">Long-term effects of delayed graft function duration on function and survival of deceased donor kidney transplants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="168300478" href="https://independent.academia.edu/MateusSwarovskyHelfer">Mateus Swarovsky Helfer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brazilian Journal of Nephrology</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Delayed graft function (DGF) is a frequent complication after deceased donor kidney transplantation with an impact on the prognosis of the transplant. Despite this, long-term impact of DGF on graft function after deceased donor kidney transplantation has not been properly evaluated. Objective: The main objective of this study was to evaluate risk factors for DGF and the impact of its occurrence and length on graft survival and function. Methods: A retrospective cohort study was performed in 517 kidney transplant recipients who received a deceased donor organ between January 2008 and December 2013. Results: The incidence of DGF was 69.3% and it was independently associated with donor&amp;#39;s final serum creatinine and age, cold ischemia time, use of antibody induction therapy and recipient&amp;#39;s diabetes mellitus. The occurrence of DGF was also associated with a higher incidence of Banff ≥ 1A grade acute rejection (P = 0.017), lower graft function up to six years after tr...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Long-term effects of delayed graft function duration on function and survival of deceased donor kidney transplants&quot;,&quot;attachmentId&quot;:69351835,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/51780644/Long_term_effects_of_delayed_graft_function_duration_on_function_and_survival_of_deceased_donor_kidney_transplants&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/51780644/Long_term_effects_of_delayed_graft_function_duration_on_function_and_survival_of_deceased_donor_kidney_transplants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="20705524" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20705524/Delayed_Graft_Function_and_Long_Term_Outcome_in_Kidney_Transplantation">Delayed Graft Function and Long-Term Outcome in Kidney Transplantation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42183068" href="https://independent.academia.edu/AntonioMistretta">Antonio Mistretta</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42007267" href="https://independent.academia.edu/AGiaquinta">A. Giaquinta</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplantation Proceedings, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Delayed Graft Function and Long-Term Outcome in Kidney Transplantation&quot;,&quot;attachmentId&quot;:41516326,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/20705524/Delayed_Graft_Function_and_Long_Term_Outcome_in_Kidney_Transplantation&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20705524/Delayed_Graft_Function_and_Long_Term_Outcome_in_Kidney_Transplantation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="99436763" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99436763/Early_Prediction_of_Graft_Outcomes_After_Kidney_Transplantation_From_Donors_After_Circulatory_Death_Biomarkers_and_Transplantation_Characteristics">Early Prediction of Graft Outcomes After Kidney Transplantation From Donors After Circulatory Death: Biomarkers and Transplantation Characteristics</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="222431748" 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href="https://www.academia.edu/69183852/Pretransplant_and_early_posttransplant_predictors_of_chronic_allograft_nephropathy_in_cadaveric_kidney_allograft_a_single_center_analysis_of_1112_cases">Pretransplant and early posttransplant predictors of chronic allograft nephropathy in cadaveric kidney allograft-a single-center analysis of 1112 cases</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39555545" href="https://independent.academia.edu/LeszekPaczek">Leszek Paczek</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplant International, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Pretransplant and early posttransplant predictors of chronic allograft nephropathy in cadaveric kidney allograft-a 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="19780003" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19780003/Outcome_of_renal_allografts_from_non_heart_beating_donors_with_delayed_graft_function">Outcome of renal allografts from non-heart-beating donors with delayed graft function</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40498421" href="https://independent.academia.edu/VassiliosPapalois">Vassilios Papalois</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplant International, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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Luke</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nephrology Dialysis Transplantation, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;The prognostic value of time needed on dialysis in patients with delayed graft function&quot;,&quot;attachmentId&quot;:65938677,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/45425921/The_prognostic_value_of_time_needed_on_dialysis_in_patients_with_delayed_graft_function&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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data-author-id="73318333" href="https://independent.academia.edu/EzzedineAbderrahim">Ezzedine Abderrahim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplantation, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Risk Factors and Consequences of Delayed Graft Function in Deceased Donor Renal Transplant Patients Receiving Antithymocyte Globulin Induction&quot;,&quot;attachmentId&quot;:104739464,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/105227535/Risk_Factors_and_Consequences_of_Delayed_Graft_Function_in_Deceased_Donor_Renal_Transplant_Patients_Receiving_Antithymocyte_Globulin_Induction&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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function and worse renal function only in kidneys with chronic pathological lesions</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39739367" href="https://independent.academia.edu/SchenaA">A. Schena</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39618817" href="https://independent.academia.edu/PaoloSDi">S. 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Allograft Loss</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50812808" href="https://independent.academia.edu/JesseSchold">Jesse Schold</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Transplantation, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Poor Predictive Value of Serum Creatinine for Renal Allograft Loss&quot;,&quot;attachmentId&quot;:47087096,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/26814405/Poor_Predictive_Value_of_Serum_Creatinine_for_Renal_Allograft_Loss&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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