Antiparkinsonian potential of cilostazol: insights into its neuroprotective effects

<!doctype html> <html lang="en"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <title>Antiparkinsonian potential of cilostazol: insights into its neuroprotective effects | Abstract</title> <meta name="keywords" content="Shireen A. Hedya, Antiparkinsonian, cilostazol, neuroprotective"/> <meta name="description" content="Cilostazol, a 2-oxo-quinoline derivative, is a selective inhibitor of phosphodiesterase-3 that increases intracellular cAMP levels and activates prote.. "/> <meta name="citation_publisher" content="Hilaris SRL" /> <meta name="citation_journal_title" content="Journal of Oncology Translational Research"> <meta name="citation_title" content="Antiparkinsonian potential of cilostazol: insights into its neuroprotective effects"> <meta name="citation_author" content="Shireen A. Hedya" /> <meta name="citation_year" content="2021"> <meta name="citation_volume" content="7"> <meta name="citation_issue" content="1"> <meta name="citation_issn" content="2476-2261"> <meta name="citation_publication_date" content="2021/01/22" /> <meta name="citation_firstpage" content="6"> <meta name="citation_lastpage" content="6"> <meta name="citation_abstract" content="Cilostazol, a 2-oxo-quinoline derivative, is a selective inhibitor of phosphodiesterase-3 that increases intracellular cAMP levels and activates protein kinase A. Cilostazol exhibited neuroprotection in focal cerebral ischemia in rats, which was attributed to its anti-apoptotic properties. Furthermore, it guarded against hypoperfusion-induced cognitive impairment resulting in protective activity in an animal model of vascular dementia. Interestingly, cilostazol proved to exert favourable effects against Alzheimer’s disease where it enhanced β-amyloid peptide degradation through autophagy modulation in N2a neuronal cells. Together, these findings further support the notion that cilostazol may possess neuroprotective effect and may show beneficial outcome in PD. The aim of this study is to explore the Neuroprotective effect of cilostazol in rotenone-induced PD model in rats. Parkinsonian rat pre-treated with cilostazol showed minimal neuronal vacuolation and minimal perivascular edema in the midbrain and striatum. Moreover, Pre-treatment of rats with cilostazol improved the motor deficits as verified by a remarkable surge in ambulation and rearing. This could be explained by the fact that cilostazol significantly raised striatal TH content as compared to the rotenone group. . In conclusion, cilostazol could be a promising candidate for PD treatment."> <meta name="citation_pdf_url" content="https://www.hilarispublisher.com/open-access/antiparkinsonian-potential-of-cilostazol-insights-into-its-neuroprotective-effects.pdf"> <meta name="citation_abstract_html_url" content="https://www.hilarispublisher.com/abstract/antiparkinsonian-potential-of-cilostazol-insights-into-its-neuroprotective-effects-53533.html">  <link rel="alternate" href="https://www.hilarispublisher.com/" hreflang="en" /> <link rel="canonical" href="https://www.hilarispublisher.com/abstract/antiparkinsonian-potential-of-cilostazol-insights-into-its-neuroprotective-effects-53533.html"> <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.11.2/css/all.min.css" /> <link rel="stylesheet" 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Hedya</p> <p><p class="MsoBodyText" style="margin-right:7px; text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman",serif">Cilostazol, a 2-oxo-quinoline derivative, is a selective inhibitor of phosphodiesterase-3 that increases intracellular cAMP levels and activates protein kinase A. Cilostazol exhibited neuroprotection in focal cerebral ischemia in rats, which was attributed to its anti-apoptotic properties. Furthermore, it guarded against hypoperfusion-induced cognitive impairment resulting in protective activity in an animal model of vascular dementia. Interestingly, cilostazol proved to exert favourable effects against Alzheimer’s disease where it enhanced β-amyloid peptide degradation through autophagy modulation in N2a neuronal cells. Together, these findings further support the notion that cilostazol may possess neuroprotective effect and may show beneficial outcome in PD. The aim of this study is to explore the Neuroprotective effect of cilostazol in rotenone-induced PD model in rats. Parkinsonian rat pre-treated with cilostazol showed minimal neuronal vacuolation and minimal perivascular edema in the midbrain and striatum. Moreover, Pre-treatment of rats with cilostazol improved the motor deficits as verified by a remarkable surge in ambulation and rearing. This could be explained by the fact that cilostazol significantly raised striatal TH content as compared to the rotenone group. . In conclusion, cilostazol could be a promising candidate for PD treatment.</span></span></p></p> <a class="btn btn-outline-primary btn-sm" href="https://www.hilarispublisher.com/open-access/antiparkinsonian-potential-of-cilostazol-insights-into-its-neuroprotective-effects.pdf" title="Click here"><i class="far fa-file-alt"></i> PDF</a> <div class="row mt-3"> <div class="col-12 col-sm-auto"> <p class="lead">Share this article</p> </div> <div class="col-12 col-sm-auto"> <div class="nav social-icons"> <a title="FB Share" target="_blank" href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/abstract/antiparkinsonian-potential-of-cilostazol-insights-into-its-neuroprotective-effects-53533.html" class="nav-link bg-facebook fab fa-facebook-f text-white"> </a> <a title="Twitter Share" target="_blank" href="https://twitter.com/share?url=https://www.hilarispublisher.com/abstract/antiparkinsonian-potential-of-cilostazol-insights-into-its-neuroprotective-effects-53533.html" 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Antiparkinsonian potential of cilostazol: insights into its neuroprotective effects | Abstract