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type='text/css'> /** This file is major component of this plugin so please don't try to edit here. */ #rmp_menu_trigger-9826 { width: 120px; height: 45px; position: fixed; top: 0; border-radius: 5px; display: none; text-decoration: none; left: 0; background: #000; transition: transform 0.5s, background-color 0.5s; } #rmp_menu_trigger-9826:hover, #rmp_menu_trigger-9826:focus { background: #000; text-decoration: unset; } #rmp_menu_trigger-9826.is-active { background: #000; } #rmp_menu_trigger-9826 .rmp-trigger-box { width: 20px; color: #fff; } #rmp_menu_trigger-9826 .rmp-trigger-icon-active, #rmp_menu_trigger-9826 .rmp-trigger-text-open { display: none; } #rmp_menu_trigger-9826.is-active .rmp-trigger-icon-active, #rmp_menu_trigger-9826.is-active .rmp-trigger-text-open { display: inline; } #rmp_menu_trigger-9826.is-active .rmp-trigger-icon-inactive, #rmp_menu_trigger-9826.is-active .rmp-trigger-text { display: none; } #rmp_menu_trigger-9826 .rmp-trigger-label { color: #fff; pointer-events: none; line-height: 20px; font-family: inherit; font-size: 17px; display: inline; text-transform: inherit; } #rmp_menu_trigger-9826 .rmp-trigger-label.rmp-trigger-label-top { display: block; margin-bottom: 12px; } #rmp_menu_trigger-9826 .rmp-trigger-label.rmp-trigger-label-bottom { display: block; margin-top: 12px; } #rmp_menu_trigger-9826 .responsive-menu-pro-inner { display: block; } #rmp_menu_trigger-9826 .responsive-menu-pro-inner, #rmp_menu_trigger-9826 .responsive-menu-pro-inner::before, #rmp_menu_trigger-9826 .responsive-menu-pro-inner::after { width: 20px; height: 2px; background-color: #fff; border-radius: 4px; position: absolute; } #rmp_menu_trigger-9826.is-active .responsive-menu-pro-inner, #rmp_menu_trigger-9826.is-active .responsive-menu-pro-inner::before, #rmp_menu_trigger-9826.is-active .responsive-menu-pro-inner::after { background-color: #fff; } #rmp_menu_trigger-9826:hover .responsive-menu-pro-inner, #rmp_menu_trigger-9826:hover .responsive-menu-pro-inner::before, #rmp_menu_trigger-9826:hover .responsive-menu-pro-inner::after { background-color: #fff; } #rmp_menu_trigger-9826 .responsive-menu-pro-inner::before { top: 10px; } #rmp_menu_trigger-9826 .responsive-menu-pro-inner::after { bottom: 10px; } #rmp_menu_trigger-9826.is-active .responsive-menu-pro-inner::after { bottom: 0; } /* Hamburger menu styling */ @media screen and (max-width: 860px) { /** Menu Title Style */ /** Menu Additional Content Style */ .menu-primary { display: none !important; } #rmp_menu_trigger-9826 { display: block; } #rmp-container-9826 { position: fixed; top: 0; margin: 0; transition: transform 0.5s; overflow: auto; display: block; width: 100%; background-color: #212121; background-image: url(""); height: 100%; left: 0; padding-top: 0px; padding-left: 0px; padding-bottom: 0px; padding-right: 0px; } #rmp-menu-wrap-9826 { padding-top: 0px; padding-left: 0px; padding-bottom: 0px; padding-right: 0px; background-color: #212121; } 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background-color 0.5s, border-color 0.5s, 0.5s; padding: 0 5%; padding-right: 50px; } #rmp-menu-wrap-9826 .rmp-menu-item-link:after, #rmp-menu-wrap-9826 .rmp-menu-item-link:before { display: none; } #rmp-menu-wrap-9826 .rmp-menu-item-link:hover { color: #fff; border-color: #212121; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-menu-item-link:focus { outline: none; border-color: unset; box-shadow: unset; } #rmp-menu-wrap-9826 .rmp-menu-item-link .rmp-font-icon { height: 50px; line-height: 50px; margin-right: 10px; font-size: 16px; } #rmp-menu-wrap-9826 .rmp-menu-current-item .rmp-menu-item-link { color: #fff; border-color: #212121; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-menu-current-item .rmp-menu-item-link:hover { color: #fff; border-color: #3f3f3f; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-menu-subarrow { position: absolute; top: 0; bottom: 0; text-align: center; overflow: hidden; background-size: cover; overflow: hidden; right: 0; border-left-style: solid; border-left-color: #212121; border-left-width: 1px; height: 40px; width: 40px; color: #fff; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-menu-subarrow:hover { color: #fff; border-color: #fff; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-menu-subarrow .rmp-font-icon { margin-right: unset; } #rmp-menu-wrap-9826 .rmp-menu-subarrow * { vertical-align: middle; line-height: 40px; } #rmp-menu-wrap-9826 .rmp-menu-subarrow-active { display: block; background-size: cover; color: #fff; border-color: #212121; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-menu-subarrow-active:hover { color: #fff; border-color: #fff; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-submenu { display: none; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-item-link { height: 50px; line-height: 50px; letter-spacing: 0px; font-size: 16px; border-bottom: 1px solid #212121; font-family: inherit; font-weight: normal; color: #fff; text-align: center; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-item-link:hover { color: #fff; border-color: #212121; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-current-item .rmp-menu-item-link { color: #fff; border-color: #212121; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-current-item .rmp-menu-item-link:hover { color: #fff; border-color: #3f3f3f; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-subarrow { right: 0; border-right: unset; border-left-style: solid; border-left-color: #212121; border-left-width: 1px; height: 40px; line-height: 40px; width: 40px; color: #fff; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-subarrow:hover { color: #fff; border-color: #fff; background-color: #3f3f3f; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-subarrow-active { color: #fff; border-color: #212121; background-color: #212121; } #rmp-menu-wrap-9826 .rmp-submenu .rmp-menu-subarrow-active:hover { color: #fff; 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#212121; color: #fff; } #rmp-menu-title-9826 > .rmp-menu-title-link { color: #fff; width: 100%; background-color: unset; text-decoration: none; } #rmp-menu-title-9826 > .rmp-menu-title-link:hover { color: #fff; } #rmp-menu-title-9826 .rmp-font-icon { font-size: 16px; } #rmp-menu-additional-content-9826 { padding-top: 0px; padding-left: 5%; padding-bottom: 0px; padding-right: 5%; color: #fff; text-align: center; font-size: 16px; } } /** This file contents common styling of menus. */ .rmp-container { display: none; visibility: visible; padding: 0px 0px 0px 0px; z-index: 99998; transition: all 0.3s; /** Scrolling bar in menu setting box **/ } .rmp-container.rmp-fade-top, .rmp-container.rmp-fade-left, .rmp-container.rmp-fade-right, .rmp-container.rmp-fade-bottom { display: none; } .rmp-container.rmp-slide-left, .rmp-container.rmp-push-left { transform: translateX(-100%); -ms-transform: translateX(-100%); -webkit-transform: translateX(-100%); -moz-transform: translateX(-100%); } .rmp-container.rmp-slide-left.rmp-menu-open, .rmp-container.rmp-push-left.rmp-menu-open { transform: translateX(0); -ms-transform: translateX(0); -webkit-transform: translateX(0); -moz-transform: translateX(0); } .rmp-container.rmp-slide-right, .rmp-container.rmp-push-right { transform: translateX(100%); -ms-transform: translateX(100%); -webkit-transform: translateX(100%); -moz-transform: translateX(100%); } .rmp-container.rmp-slide-right.rmp-menu-open, .rmp-container.rmp-push-right.rmp-menu-open { transform: translateX(0); -ms-transform: translateX(0); -webkit-transform: translateX(0); -moz-transform: translateX(0); } .rmp-container.rmp-slide-top, .rmp-container.rmp-push-top { transform: translateY(-100%); -ms-transform: translateY(-100%); -webkit-transform: translateY(-100%); -moz-transform: translateY(-100%); } .rmp-container.rmp-slide-top.rmp-menu-open, .rmp-container.rmp-push-top.rmp-menu-open { transform: translateY(0); -ms-transform: translateY(0); -webkit-transform: translateY(0); -moz-transform: translateY(0); } .rmp-container.rmp-slide-bottom, .rmp-container.rmp-push-bottom { transform: translateY(100%); -ms-transform: translateY(100%); -webkit-transform: translateY(100%); -moz-transform: translateY(100%); } .rmp-container.rmp-slide-bottom.rmp-menu-open, .rmp-container.rmp-push-bottom.rmp-menu-open { transform: translateX(0); -ms-transform: translateX(0); -webkit-transform: translateX(0); -moz-transform: translateX(0); } .rmp-container::-webkit-scrollbar { width: 0px; } .rmp-container ::-webkit-scrollbar-track { box-shadow: inset 0 0 5px transparent; } .rmp-container ::-webkit-scrollbar-thumb { background: transparent; } .rmp-container ::-webkit-scrollbar-thumb:hover { background: transparent; } .rmp-container .rmp-menu-wrap .rmp-menu { transition: none; border-radius: 0; box-shadow: none; background: none; border: 0; bottom: auto; box-sizing: border-box; clip: auto; color: #666; display: block; float: none; font-family: inherit; font-size: 14px; height: auto; left: auto; line-height: 1.7; list-style-type: none; margin: 0; min-height: auto; max-height: none; opacity: 1; outline: none; overflow: visible; padding: 0; position: relative; pointer-events: auto; right: auto; text-align: left; text-decoration: none; text-indent: 0; text-transform: none; transform: none; top: auto; visibility: inherit; width: auto; word-wrap: break-word; white-space: normal; } .rmp-container .rmp-menu-additional-content { display: block; word-break: break-word; } .rmp-container .rmp-menu-title { display: flex; flex-direction: column; } .rmp-container .rmp-menu-title .rmp-menu-title-image { max-width: 100%; margin-bottom: 15px; display: block; margin: auto; margin-bottom: 15px; } button.rmp_menu_trigger { z-index: 999999; overflow: hidden; outline: none; border: 0; display: none; margin: 0; transition: transform 0.5s, background-color 0.5s; padding: 0; } button.rmp_menu_trigger .responsive-menu-pro-inner::before, button.rmp_menu_trigger 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name="_mc4wp_form_element_id" value="mc4wp-form-1" /><div class="mc4wp-response"></div></form></div></section> </div></div><div class="site-inner"><div class="wrap"><div class="content-sidebar-wrap"><main class="content"><div class="breadcrumb" itemprop="breadcrumb" itemscope itemtype="https://schema.org/BreadcrumbList">You are here: <span class="breadcrumb-link-wrap" itemprop="itemListElement" itemscope itemtype="https://schema.org/ListItem"><a class="breadcrumb-link" href="https://pennmemorycenter.org/" itemprop="item"><span class="breadcrumb-link-text-wrap" itemprop="name">Home</span></a><meta itemprop="position" content="1"></span> <span aria-label="breadcrumb separator">/</span> Disease-modifying therapies for Alzheimer’s</div><article class="post-11222 page type-page status-publish entry" itemscope itemtype="https://schema.org/CreativeWork"><header class="entry-header"><h1 class="entry-title" itemprop="headline">Disease-modifying therapies for Alzheimer’s</h1> </header><div class="entry-content" itemprop="text"><p><picture decoding="async" class="wp-image-11225 size-large aligncenter"> <source type="image/webp" srcset="https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-1024x540.jpeg.webp 1024w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-300x158.jpeg.webp 300w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-768x405.jpeg.webp 768w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-1536x810.jpeg.webp 1536w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-2048x1080.jpeg.webp 2048w" sizes="(max-width: 1024px) 100vw, 1024px"/> <img decoding="async" src="https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-1024x540.jpeg" alt="Beta-amyloid plaques" width="1024" height="540" srcset="https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-1024x540.jpeg 1024w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-300x158.jpeg 300w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-768x405.jpeg 768w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-1536x810.jpeg 1536w, https://pennmemorycenter.org/wp-content/uploads/2022/12/AdobeStock_466014399-2048x1080.jpeg 2048w" sizes="(max-width: 1024px) 100vw, 1024px"/> </picture> </p> <p><span data-contrast="auto">Alzheimer’s disease is complex, and no single drug or treatment is likely to work for all people living with the disease. Still, in recent years, scientists have made tremendous progress in better understanding Alzheimer’s and related causes of dementia and in developing and testing new treatments.</span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><b><span data-contrast="auto">Understanding Amyloid-Beta and Alzheimer’s Treatments</span></b><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">In Alzheimer’s disease, the brain accumulates a protein called amyloid-beta, leading to the degeneration of neurons. Several drugs are being developed to target these amyloid-beta plaques, specifically monoclonal antibodies. These drugs aim to slow the progression of the disease in its early stages.</span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">The Penn Memory Center (PMC) is actively involved in clinical trials and treatments for Alzheimer’s. Below, we highlight two major FDA-approved therapies: </span>Leqembi (lecanemab) and Kisunla (donanemab).</p> <p><b><span data-contrast="auto">Leqembi (Lecanemab)</span></b><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">Leqembi is a monoclonal antibody that targets amyloid-beta to slow cognitive decline in individuals with early-stage Alzheimer’s disease. It was fully approved by the FDA in 2023. </span><span data-contrast="none">The drug is given as an hour-long intravenous (IV) infusion every two weeks. It is currently available to Penn Medicine patients. </span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">In a study of 1,800 participants, Leqembi slowed cognitive decline by 27% compared to a placebo. However, patients receiving Leqembi had a higher risk of brain bleeding and swelling.</span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">“The benefit is real; so too are the risks.” — Dr. Jason Karlawish, PMC co-director</span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><a href="https://pennmemorycenter.org/leqembi/"><b><span data-contrast="none">Learn More About Leqembi</span></b></a> <span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><b><span data-contrast="auto">Kisunla (Donanemab)</span></b><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">Kisunla, also known as donanemab, is another monoclonal antibody treatment that targets amyloid plaques. It’s designed for people with early symptomatic Alzheimer’s, including mild cognitive impairment and mild dementia. It was fully approved by the FDA in 2024. The drug is administered once a month via a 30-minute intravenous infusion, with many participants completing their course of treatment within 12 months.</span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">The Penn Memory Center is working to make Kisunla available to eligible patients. More details will be shared as plans develop.</span></p> <p><span data-contrast="auto">The approval of Kisunla offers another treatment option for patients with early-stage Alzheimer’s. PMC Co-Directors Dr. David Wolk emphasized the drug’s precision-medicine approach in targeting amyloid plaques and calls it “an exciting advance.”</span><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><b><span data-contrast="auto">Learn More</span></b><span data-ccp-props="{"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">For more information on these treatments, watch our </span>PMC Community Discussion on Anti-Amyloid Treatments for Alzheimer’s Disease.</p> <div class="video-container"><iframe title="An Update on Anti-Amyloid Treatments for Alzheimer's Disease" width="500" height="281" src="https://www.youtube.com/embed/C3uhPqxrl1Q?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></div> </div></article></main><aside class="sidebar sidebar-primary widget-area" 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