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Available in 18 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-18" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">18 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%83%D8%A7%D8%B3%D9%8A%D8%B1%D9%8A%D9%81%D9%8A%D9%85%D8%A7%D8%A8/%D8%A5%D9%8A%D9%85%D9%8A%D9%81%D9%8A%D9%85%D8%A7%D8%A8" title="كاسيريفيماب/إيميفيماب – Arabic" lang="ar" hreflang="ar" data-title="كاسيريفيماب/إيميفيماب" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Casirivimab/imdevimab" title="Casirivimab/imdevimab – Catalan" lang="ca" hreflang="ca" data-title="Casirivimab/imdevimab" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Kasirivimab/imdevimab" title="Kasirivimab/imdevimab – Czech" lang="cs" hreflang="cs" data-title="Kasirivimab/imdevimab" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Casirivimab/Imdevimab" title="Casirivimab/Imdevimab – German" lang="de" hreflang="de" data-title="Casirivimab/Imdevimab" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%9A%CE%B1%CF%83%CE%B9%CF%81%CE%B9%CE%B2%CE%B9%CE%BC%CE%AC%CE%BC%CF%80%CE%B7/%CE%B9%CE%BC%CE%BD%CF%84%CE%B5%CE%B2%CE%B9%CE%BC%CE%AC%CE%BC%CF%80%CE%B7" title="Κασιριβιμάμπη/ιμντεβιμάμπη – Greek" lang="el" hreflang="el" data-title="Κασιριβιμάμπη/ιμντεβιμάμπη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Casirivimab/imdevimab" title="Casirivimab/imdevimab – Spanish" lang="es" hreflang="es" data-title="Casirivimab/imdevimab" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/REGN-COV2" title="REGN-COV2 – French" lang="fr" hreflang="fr" data-title="REGN-COV2" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/REGN-COV2" title="REGN-COV2 – Korean" lang="ko" hreflang="ko" data-title="REGN-COV2" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AB%E3%82%B7%E3%83%AA%E3%83%93%E3%83%9E%E3%83%96%E3%83%BB%E3%82%A4%E3%83%A0%E3%83%87%E3%83%93%E3%83%9E%E3%83%96" title="カシリビマブ・イムデビマブ – Japanese" lang="ja" hreflang="ja" data-title="カシリビマブ・イムデビマブ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/REGN-COV2" title="REGN-COV2 – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="REGN-COV2" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%95%E0%AC%BE%E0%AC%B8%E0%AC%BF%E0%AC%B0%E0%AC%BF%E0%AC%AD%E0%AC%BF%E0%AC%AE%E0%AC%BE%E0%AC%AC/%E0%AC%87%E0%AC%AE%E0%AC%A1%E0%AD%87%E0%AC%AD%E0%AC%BF%E0%AC%AE%E0%AC%BE%E0%AC%AC" title="କାସିରିଭିମାବ/ଇମଡେଭିମାବ – Odia" lang="or" hreflang="or" data-title="କାସିରିଭିମାବ/ଇମଡେଭିମାବ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Kasiriwimab/imdewimab" title="Kasiriwimab/imdewimab – Polish" lang="pl" hreflang="pl" data-title="Kasiriwimab/imdewimab" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/REGN-COV2" title="REGN-COV2 – Portuguese" lang="pt" hreflang="pt" data-title="REGN-COV2" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9A%D0%B0%D0%B7%D0%B8%D1%80%D0%B8%D0%B2%D0%B8%D0%BC%D0%B0%D0%B1/%D0%B8%D0%BC%D0%B4%D0%B5%D0%B2%D0%B8%D0%BC%D0%B0%D0%B1" title="Казиривимаб/имдевимаб – Russian" lang="ru" hreflang="ru" data-title="Казиривимаб/имдевимаб" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Kasirivimab/imdevimab" title="Kasirivimab/imdevimab – Slovenian" lang="sl" hreflang="sl" data-title="Kasirivimab/imdevimab" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%84%E0%B8%B2%E0%B8%8B%E0%B8%B4%E0%B8%A3%E0%B8%B4%E0%B8%A7%E0%B8%B4%E0%B9%81%E0%B8%A1%E0%B8%9A/%E0%B8%AD%E0%B8%B4%E0%B8%A1%E0%B8%94%E0%B8%B5%E0%B8%A7%E0%B8%B4%E0%B9%81%E0%B8%A1%E0%B8%9A" title="คาซิริวิแมบ/อิมดีวิแมบ – Thai" lang="th" hreflang="th" data-title="คาซิริวิแมบ/อิมดีวิแมบ" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9A%D0%B0%D1%81%D0%B8%D1%80%D0%B8%D0%B2%D1%96%D0%BC%D0%B0%D0%B1/%D1%96%D0%BC%D0%B4%D0%B5%D0%B2%D1%96%D0%BC%D0%B0%D0%B1" title="Касиривімаб/імдевімаб – Ukrainian" lang="uk" hreflang="uk" data-title="Касиривімаб/імдевімаб" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%8D%A1%E8%A5%BF%E7%91%9E%E5%96%AE%E6%8A%97/%E4%BC%8A%E5%BE%B7%E5%96%AE%E6%8A%97" title="卡西瑞單抗/伊德單抗 – Chinese" lang="zh" hreflang="zh" data-title="卡西瑞單抗/伊德單抗" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q99328880#sitelinks-wikipedia" title="Edit interlanguage links" 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dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Antiviral combination medication</div> <p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <style data-mw-deduplicate="TemplateStyles:r1269284339">@media screen{html.skin-theme-clientpref-night .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Casirivimab/imdevimab">Casirivimab/imdevimab</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span class="mw-default-size dark_mode_safe" typeof="mw:File/Frameless"><a href="/wiki/File:REGN-COV2_binding_SARS-CoV-2_spike_protein.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d2/REGN-COV2_binding_SARS-CoV-2_spike_protein.png/220px-REGN-COV2_binding_SARS-CoV-2_spike_protein.png" decoding="async" width="220" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d2/REGN-COV2_binding_SARS-CoV-2_spike_protein.png/330px-REGN-COV2_binding_SARS-CoV-2_spike_protein.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d2/REGN-COV2_binding_SARS-CoV-2_spike_protein.png/440px-REGN-COV2_binding_SARS-CoV-2_spike_protein.png 2x" data-file-width="2048" data-file-height="2048" /></a></span><div class="infobox-caption">REGN10933 (blue) and REGN10987 (orange) bound to SARS-CoV-2 spike protein (pink). From <span class="plainlinks"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a>: <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/6VSB">6VSB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/6XDG">6XDG</a></span>.</div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Combination of</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Casirivimab" class="mw-redirect" title="Casirivimab">Casirivimab</a></th><td class="infobox-data"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a> against <a href="/wiki/Coronavirus_spike_protein" title="Coronavirus spike protein">spike protein</a> of <a href="/wiki/Severe_acute_respiratory_syndrome_coronavirus_2" class="mw-redirect" title="Severe acute respiratory syndrome coronavirus 2">SARS-CoV-2</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Imdevimab" class="mw-redirect" title="Imdevimab">Imdevimab</a></th><td class="infobox-data">Monoclonal antibody against spike protein of SARS-CoV-2</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">REGEN-COV, Ronapreve</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/casirivimab-and-imdevimab.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a620063.html">a620063</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Casirivimab">Casirivimab</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> B2<sup id="cite_ref-Ronapreve_APM_summary_1-0" class="reference"><a href="#cite_note-Ronapreve_APM_summary-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AusPAR:_Casirivimab/imdevimab_2-0" class="reference"><a href="#cite_note-AusPAR:_Casirivimab/imdevimab-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">Intravenous</a>, <a href="/wiki/Subcutaneous_injection" class="mw-redirect" title="Subcutaneous injection">subcutaneous injection</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_J06" title="ATC code J06">J06BD07</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=J06BD07">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)<sup id="cite_ref-Ronapreve_APM_summary_1-1" class="reference"><a href="#cite_note-Ronapreve_APM_summary-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AusPAR:_Casirivimab/imdevimab_2-1" class="reference"><a href="#cite_note-AusPAR:_Casirivimab/imdevimab-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a> / Schedule D<sup id="cite_ref-Casirivimab_(casirivimab)_and_imdevimab_(imdevimab)_5-0" class="reference"><a href="#cite_note-Casirivimab_(casirivimab)_and_imdevimab_(imdevimab)-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United Kingdom">UK</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)<sup id="cite_ref-Ronapreve_SmPC_7-0" class="reference"><a href="#cite_note-Ronapreve_SmPC-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a> via emergency use authorization<sup id="cite_ref-REGEN-COV_FDA_label_8-0" class="reference"><a href="#cite_note-REGEN-COV_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20201121_9-0" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-Ronapreve_EPAR_10-0" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li> <li>Rx-only<sup id="cite_ref-Roche_PR_20210720_12-0" class="reference"><a href="#cite_note-Roche_PR_20210720-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB15691">DB15691</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D12142">D12142</a></span></li></ul></div></td></tr></tbody></table> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1269284339"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Casirivimab">Casirivimab</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/File:Engineered_monoclonal_antibodies.svg" title="File:Engineered monoclonal antibodies.svg">Type</a></th><td class="infobox-data">Whole antibody</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Monoclonal_antibody#Production" title="Monoclonal antibody">Source</a></th><td class="infobox-data"><a href="/wiki/Human" title="Human">Human</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Antigen" title="Antigen">Target</a></th><td class="infobox-data"><a href="/wiki/Coronavirus_spike_protein" title="Coronavirus spike protein">Spike protein</a> of <a href="/wiki/Severe_acute_respiratory_syndrome_coronavirus_2" class="mw-redirect" title="Severe acute respiratory syndrome coronavirus 2">SARS-CoV-2</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">REGN10933</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>None</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=2415933-42-3">2415933-42-3</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB15941">DB15941</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/J0FI6WE1QN">J0FI6WE1QN</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D11938">D11938</a></span></li></ul></div></td></tr></tbody></table> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1269284339"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Imdevimab">Imdevimab</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/File:Engineered_monoclonal_antibodies.svg" title="File:Engineered monoclonal antibodies.svg">Type</a></th><td class="infobox-data">Whole antibody</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Monoclonal_antibody#Production" title="Monoclonal antibody">Source</a></th><td class="infobox-data"><a href="/wiki/Human" title="Human">Human</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Antigen" title="Antigen">Target</a></th><td class="infobox-data"><a href="/wiki/Coronavirus_spike_protein" title="Coronavirus spike protein">Spike protein</a> of <a href="/wiki/Severe_acute_respiratory_syndrome_coronavirus_2" class="mw-redirect" title="Severe acute respiratory syndrome coronavirus 2">SARS-CoV-2</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">REGN10987</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>None</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=2415933-40-1">2415933-40-1</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB15940">DB15940</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/2Z3DQD2JHM">2Z3DQD2JHM</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D11939">D11939</a></span></li></ul></div></td></tr></tbody></table> <p><b>Casirivimab/imdevimab</b>, sold under the brand name <b>REGEN‑COV</b> among others,<sup id="cite_ref-REGEN-COV_FDA_label_8-1" class="reference"><a href="#cite_note-REGEN-COV_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ronapreve_EPAR_10-1" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> is a combination <a href="/wiki/Medicine" title="Medicine">medicine</a> used for the treatment and prevention of <a href="/wiki/COVID-19" title="COVID-19">COVID‑19</a>.<sup id="cite_ref-Ronapreve_EPAR_10-2" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> It consists of two <a href="/wiki/Human_monoclonal_antibodies" class="mw-redirect" title="Human monoclonal antibodies">human monoclonal antibodies</a>, casirivimab and imdevimab that must be mixed together and administered as an infusion or subcutaneous injection.<sup id="cite_ref-FDA_fact_sheet_13-0" class="reference"><a href="#cite_note-FDA_fact_sheet-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-REGEN-COV_FDA_label_8-2" class="reference"><a href="#cite_note-REGEN-COV_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ronapreve_EPAR_10-3" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The combination of two antibodies is intended to prevent <a href="/wiki/Drug_resistance" title="Drug resistance">mutational escape</a>.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> It is also available as a <a href="/wiki/Co-formulated" class="mw-redirect" title="Co-formulated">co-formulated</a> product.<sup id="cite_ref-FDA_fact_sheet_13-1" class="reference"><a href="#cite_note-FDA_fact_sheet-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> It was developed by the American biotechnology company <a href="/wiki/Regeneron_Pharmaceuticals" title="Regeneron Pharmaceuticals">Regeneron Pharmaceuticals</a>.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>The most common side effects include allergic reactions, which include infusion related reactions, injection site reactions,<sup id="cite_ref-Ronapreve_EPAR_10-4" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> brief pain, weakness and others.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p>The combination is approved under the brand name <b>Ronapreve</b> for medical use in Japan, the United Kingdom, the European Union, and Australia.<sup id="cite_ref-Ronapreve_APM_summary_1-2" class="reference"><a href="#cite_note-Ronapreve_APM_summary-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ronapreve_SmPC_7-1" class="reference"><a href="#cite_note-Ronapreve_SmPC-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ronapreve_EPAR_10-5" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Roche_PR_20210720_12-1" class="reference"><a href="#cite_note-Roche_PR_20210720-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>In January 2022, the U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) revised the authorizations for two monoclonal antibody treatments – <a href="/wiki/Bamlanivimab/etesevimab" title="Bamlanivimab/etesevimab">bamlanivimab/etesevimab</a> (administered together) and casirivimab/imdevimab – to limit their use to only when the recipients are likely to have been infected with or exposed to a variant that is susceptible to these treatments because data show these treatments are highly unlikely to be active against the <a href="/wiki/SARS-CoV-2_Omicron_variant" title="SARS-CoV-2 Omicron variant">omicron variant</a>.<sup id="cite_ref-FDA_PR_20220124_20-0" class="reference"><a href="#cite_note-FDA_PR_20220124-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In the European Union, the combination is <a href="/wiki/Indication_(medicine)" title="Indication (medicine)">indicated</a> for the treatment of COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) who do not require supplemental oxygen and who are at high increased risk of progressing to severe COVID‑19;<sup id="cite_ref-Ronapreve_EPAR_10-6" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> and for the prevention of COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb).<sup id="cite_ref-Ronapreve_EPAR_10-7" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Deployment">Deployment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=2" title="Edit section: Deployment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>REGEN‑COV is manufactured at the Regeneron's manufacturing facility in <a href="/wiki/Rensselaer,_New_York" title="Rensselaer, New York">Rensselaer, New York</a>.<sup id="cite_ref-Williams_21-0" class="reference"><a href="#cite_note-Williams-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> In September 2020, to free up manufacturing capacity for REGEN‑COV, Regeneron began to shift production of its existing products from Rensselaer to the Irish city of <a href="/wiki/Limerick" title="Limerick">Limerick</a>.<sup id="cite_ref-Stanton_22-0" class="reference"><a href="#cite_note-Stanton-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p><p>Regeneron has a deal in place with <a href="/wiki/Hoffmann-La_Roche" class="mw-redirect" title="Hoffmann-La Roche">Roche</a> (<a href="/wiki/Genentech" title="Genentech">Genentech</a>)<sup id="cite_ref-Genentech_PR_20200819_23-0" class="reference"><a href="#cite_note-Genentech_PR_20200819-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> to manufacture and market REGEN‑COV outside the United States.<sup id="cite_ref-Regeneron_PR_20210126_24-0" class="reference"><a href="#cite_note-Regeneron_PR_20210126-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=3" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>On 2 October 2020, Regeneron Pharmaceuticals announced that then-<a href="/wiki/President_of_the_United_States" title="President of the United States">US President</a> <a href="/wiki/Donald_Trump" title="Donald Trump">Donald Trump</a> had received "a single 8 gram dose of REGN-COV2" <a href="/wiki/White_House_COVID-19_outbreak" title="White House COVID-19 outbreak">after testing positive</a> for SARS-CoV-2.<sup id="cite_ref-Thomas2020_26-0" class="reference"><a href="#cite_note-Thomas2020-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hackett2020_27-0" class="reference"><a href="#cite_note-Hackett2020-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> The drug was provided by the company in response to a "<a href="/wiki/Compassionate_use" class="mw-redirect" title="Compassionate use">compassionate use</a>" (temporary authorization for use) request from the president's physicians.<sup id="cite_ref-Thomas2020_26-1" class="reference"><a href="#cite_note-Thomas2020-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p><p>In August 2021, <a href="/wiki/List_of_governors_of_Texas" title="List of governors of Texas">Texas Governor</a> <a href="/wiki/Greg_Abbott" title="Greg Abbott">Greg Abbott</a> received REGEN‑COV after testing positive for COVID‑19.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Economics">Economics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=4" title="Edit section: Economics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In January 2021, the United States agreed to purchase 1.25 million doses of the drug for $2.625 billion, at $2,100 per dose.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> On 14 September, another 1.4 million doses were purchased for the same price, totaling $2.94 billion.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p><p>In January 2021, the German government purchased 200,000 doses for €400 million at €2,000 per dose.<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p><p>In May 2021, Roche India and Cipla announced that the medicine would be available in India for Rs 59,750 ($808.31) per dose.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>In September 2021, the World Health Organization urged producers and governments to address the drug's high cost and called for technology sharing to enable the manufacture of biosimilar versions. The WHO also said that <a href="/wiki/Unitaid" title="Unitaid">Unitaid</a> is negotiating with Roche for lower prices and equitable distribution, especially in low- and middle income countries.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Legal_status">Legal status</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=5" title="Edit section: Legal status"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In November 2021, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) recommended granting a marketing authorization in the European Union for casirivimab/imdevimab (Ronapreve) for the treatment and prevention of COVID‑19.<sup id="cite_ref-Ronapreve:_Pending_EC_decision_35-0" class="reference"><a href="#cite_note-Ronapreve:_Pending_EC_decision-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EMA_Ronapreve_36-0" class="reference"><a href="#cite_note-EMA_Ronapreve-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> The company that applied for authorization of Ronapreve is Roche Registration GmbH.<sup id="cite_ref-EMA_Ronapreve_36-1" class="reference"><a href="#cite_note-EMA_Ronapreve-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> Casirivimab/imdevimab was approved for medical use in the European Union in November 2021.<sup id="cite_ref-Ronapreve_EPAR_10-8" class="reference"><a href="#cite_note-Ronapreve_EPAR-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=6" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="COVID-19">COVID-19</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=7" title="Edit section: COVID-19"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>On 21 November 2020, the U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) issued an <a href="/wiki/Emergency_use_authorization" class="mw-redirect" title="Emergency use authorization">emergency use authorization</a> (EUA) for casirivimab and imdevimab to be administered together for the treatment of mild to moderate [COVID‑19] in people twelve years of age or older weighing at least 40 kilograms (88 lb) with positive results of direct SARS-CoV-2 viral testing and who are at high risk for progressing to severe COVID‑19.<sup id="cite_ref-FDA_PR_20201121_9-1" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Regeneron_PR_20210126_24-1" class="reference"><a href="#cite_note-Regeneron_PR_20210126-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_fact_sheet_13-2" class="reference"><a href="#cite_note-FDA_fact_sheet-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_38-0" class="reference"><a href="#cite_note-FDA_EUA-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> This includes those who are 65 years of age or older or who have certain chronic medical conditions.<sup id="cite_ref-FDA_PR_20201121_9-2" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Casirivimab and imdevimab must be administered together by intravenous (IV) infusion or subcutaneous injection.<sup id="cite_ref-FDA_PR_20201121_9-3" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_fact_sheet_13-3" class="reference"><a href="#cite_note-FDA_fact_sheet-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Casirivimab and imdevimab are not authorized for people who are hospitalized due to COVID‑19 or require oxygen therapy due to COVID‑19.<sup id="cite_ref-FDA_PR_20201121_9-4" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> A benefit of casirivimab and imdevimab treatment has not been shown in people hospitalized due to COVID‑19.<sup id="cite_ref-FDA_PR_20201121_9-5" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Monoclonal antibodies, such as casirivimab and imdevimab, may be associated with worse clinical outcomes when administered to hospitalized people with COVID‑19 requiring high flow oxygen or mechanical ventilation.<sup id="cite_ref-FDA_PR_20201121_9-6" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> In June 2021, the EUA was revised to authorize "the use of the unapproved product, REGEN‑COV (casirivimab and imdevimab) co-formulated product and REGEN‑COV (casirivimab and imdevimab) supplied as individual vials to be administered together, for the treatment of mild to moderate COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID‑19, including hospitalization or death".<sup id="cite_ref-FDA_fact_sheet_13-4" class="reference"><a href="#cite_note-FDA_fact_sheet-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-REGEN-COV_FDA_label_8-3" class="reference"><a href="#cite_note-REGEN-COV_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>The EUA was issued to Regeneron Pharmaceuticals Inc.<sup id="cite_ref-FDA_PR_20201121_9-7" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Regeneron_PR_20210126_24-2" class="reference"><a href="#cite_note-Regeneron_PR_20210126-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_38-1" class="reference"><a href="#cite_note-FDA_EUA-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> </p><p>In February 2021, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) started a rolling review of data on the REGN‑COV2 antibody combination (casirivimab/imdevimab), which is being co-developed by Regeneron Pharmaceuticals, Inc. and F. Hoffman-La Roche, Ltd (Roche) for the treatment and prevention of COVID‑19.<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> In February 2021, the CHMP concluded that the combination, also known as REGN-COV2, can be used for the treatment of confirmed COVID‑19 in people who do not require supplemental oxygen and who are at high risk of progressing to severe COVID‑19.<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> </p><p>The <a href="/wiki/Central_Drugs_Standard_Control_Organisation" title="Central Drugs Standard Control Organisation">Central Drugs Standards Control Organisation (CDSCO)</a> in India, on 5 May 2021, granted an Emergency Use Authorization to <a href="/wiki/Hoffmann-La_Roche" class="mw-redirect" title="Hoffmann-La Roche">Roche</a> (<a href="/wiki/Genentech" title="Genentech">Genentech</a>)<sup id="cite_ref-Genentech_PR_20200819_23-1" class="reference"><a href="#cite_note-Genentech_PR_20200819-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Regeneron" class="mw-redirect" title="Regeneron">Regeneron</a><sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> for use of the casirivimab/imdevimab cocktail in the country. The announcement came in light of the <a href="/wiki/COVID-19_pandemic_in_India" title="COVID-19 pandemic in India">second wave</a> of the COVID‑19 pandemic in India. Roche India maintains partnership with <a href="/wiki/Cipla" title="Cipla">Cipla</a>, thereby permitting the latter to market the drug in the country.<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> </p><p>In July 2021, the US FDA revised the emergency use authorization (EUA) for REGEN‑COV (casirivimab and imdevimab, administered together) authorizing REGEN‑COV for emergency use as post-exposure prophylaxis (prevention) for COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) who are at high risk for progression to severe COVID‑19, including hospitalization or death.<sup id="cite_ref-FDA_PR_20210730_45-0" class="reference"><a href="#cite_note-FDA_PR_20210730-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> REGEN‑COV remains authorized for the treatment of mild-to-moderate COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID‑19, including hospitalization or death.<sup id="cite_ref-FDA_PR_20210730_45-1" class="reference"><a href="#cite_note-FDA_PR_20210730-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p><p>In April 2021, <a href="/wiki/Hoffmann-La_Roche" class="mw-redirect" title="Hoffmann-La Roche">Roche</a> (<a href="/wiki/Genentech" title="Genentech">Genentech</a>)<sup id="cite_ref-Genentech_PR_20200819_23-2" class="reference"><a href="#cite_note-Genentech_PR_20200819-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Regeneron" class="mw-redirect" title="Regeneron">Regeneron</a> announced that the Phase III <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trial</a> REGN-COV 2069 met both primary and secondary endpoints, reducing risk of infection by 81% for the non-infected participants, and reducing time-to-resolution of symptoms for symptomatic participants to one week vs. three weeks in the placebo group.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> </p><p>In June 2021, preliminary results form the Recovery trial showed reduced mortality from 30% to 24% in people that had produced no antibodies themselves which were 33% of the total of participants.<sup id="cite_ref-Kupferschmidt_47-0" class="reference"><a href="#cite_note-Kupferschmidt-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Trials">Trials</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=8" title="Edit section: Trials"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In a clinical trial of people with COVID‑19, casirivimab and imdevimab, administered together, were shown to reduce COVID‑19-related hospitalization or emergency room visits in people at high risk for disease progression within 28 days after treatment when compared to placebo.<sup id="cite_ref-FDA_PR_20201121_9-8" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The safety and effectiveness of this investigational therapy for use in the treatment of COVID‑19 continues to be evaluated.<sup id="cite_ref-FDA_PR_20201121_9-9" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>The data supporting the emergency use authorization (EUA) for casirivimab and imdevimab are based on a <a href="/wiki/Randomized_controlled_trial" title="Randomized controlled trial">randomized</a>, <a href="/wiki/Blinded_experiment" title="Blinded experiment">double-blind</a>, <a href="/wiki/Placebo-controlled_study" title="Placebo-controlled study">placebo-controlled</a> <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trial</a> in 799 non-hospitalized adults with mild to moderate COVID‑19 symptoms.<sup id="cite_ref-FDA_PR_20201121_9-10" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Of these participants, 266 received a single intravenous infusion of 2,400 milligrams casirivimab and imdevimab (1,200 mg of each), 267 received 8,000 mg casirivimab and imdevimab (4,000 mg of each), and 266 received a placebo, within three days of obtaining a positive SARS-CoV-2 viral test.<sup id="cite_ref-FDA_PR_20201121_9-11" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>The prespecified primary endpoint for the trial was time-weighted average change in <a href="/wiki/Viral_load" title="Viral load">viral load</a> from baseline.<sup id="cite_ref-FDA_PR_20201121_9-12" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Viral load reduction in participants treated with casirivimab and imdevimab was larger than in participants treated with placebo at day seven.<sup id="cite_ref-FDA_PR_20201121_9-13" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> However, the most important evidence that casirivimab and imdevimab administered together may be effective came from the predefined secondary endpoint of medically attended visits related to COVID‑19, particularly hospitalizations and emergency room visits within 28 days after treatment.<sup id="cite_ref-FDA_PR_20201121_9-14" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> For participants at high risk for disease progression, hospitalizations and emergency room visits occurred in 3% of casirivimab and imdevimab-treated participants on average compared to 9% in placebo-treated participants.<sup id="cite_ref-FDA_PR_20201121_9-15" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The effects on viral load, reduction in hospitalizations and ER visits were similar in participants receiving either of the two casirivimab and imdevimab doses.<sup id="cite_ref-FDA_PR_20201121_9-16" class="reference"><a href="#cite_note-FDA_PR_20201121-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>As of September 2020, REGEN‑COV is being evaluated as part of the <a href="/wiki/Recovery_Trial" class="mw-redirect" title="Recovery Trial">Recovery Trial</a>,<sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> and in June 2021 the first results of the <a href="#Research">research</a> were announced with evidence proving the effectiveness of the treatment.<sup id="cite_ref-Kupferschmidt_47-1" class="reference"><a href="#cite_note-Kupferschmidt-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=9" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-Ronapreve_APM_summary-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Ronapreve_APM_summary_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Ronapreve_APM_summary_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Ronapreve_APM_summary_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.tga.gov.au/apm-summary/ronapreve">"Ronapreve"</a>. <i>Therapeutic Goods Administration (TGA)</i>. 18 October 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211023060240/https://www.tga.gov.au/apm-summary/ronapreve">Archived</a> from the original on 23 October 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">22 October</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Therapeutic+Goods+Administration+%28TGA%29&rft.atitle=Ronapreve&rft.date=2021-10-18&rft_id=https%3A%2F%2Fwww.tga.gov.au%2Fapm-summary%2Fronapreve&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-AusPAR:_Casirivimab/imdevimab-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-AusPAR:_Casirivimab/imdevimab_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AusPAR:_Casirivimab/imdevimab_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.tga.gov.au/auspar/auspar-casirivimabimdevimab">"AusPAR: Casirivimab/imdevimab"</a>. <i>Therapeutic Goods Administration (TGA)</i>. 2 November 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211121105334/https://www.tga.gov.au/auspar/auspar-casirivimabimdevimab">Archived</a> from the original on 21 November 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">23 March</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Therapeutic+Goods+Administration+%28TGA%29&rft.atitle=AusPAR%3A+Casirivimab%2Fimdevimab&rft.date=2021-11-02&rft_id=https%3A%2F%2Fwww.tga.gov.au%2Fauspar%2Fauspar-casirivimabimdevimab&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.tga.gov.au/resources/resource/guidance/updates-prescribing-medicines-pregnancy-database">"Updates to the Prescribing Medicines in Pregnancy database"</a>. <i>Therapeutic Goods Administration (TGA)</i>. 12 May 2022. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220403064059/https://www.tga.gov.au/updates-prescribing-medicines-pregnancy-database">Archived</a> from the original on 3 April 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">13 May</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Therapeutic+Goods+Administration+%28TGA%29&rft.atitle=Updates+to+the+Prescribing+Medicines+in+Pregnancy+database&rft.date=2022-05-12&rft_id=https%3A%2F%2Fwww.tga.gov.au%2Fresources%2Fresource%2Fguidance%2Fupdates-prescribing-medicines-pregnancy-database&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.tga.gov.au/covid-19-treatment-roche-products-pty-ltd-casirivimab-imdevimab-ronapreve">"COVID-19 treatment: Roche Products Pty Ltd, casirivimab + imdevimab (Ronapreve)"</a>. <i>Therapeutic Goods Administration (TGA)</i>. 15 October 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211024103552/https://www.tga.gov.au/covid-19-treatment-roche-products-pty-ltd-casirivimab-imdevimab-ronapreve">Archived</a> from the original on 24 October 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">22 October</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Therapeutic+Goods+Administration+%28TGA%29&rft.atitle=COVID-19+treatment%3A+Roche+Products+Pty+Ltd%2C+casirivimab+%2B+imdevimab+%28Ronapreve%29&rft.date=2021-10-15&rft_id=https%3A%2F%2Fwww.tga.gov.au%2Fcovid-19-treatment-roche-products-pty-ltd-casirivimab-imdevimab-ronapreve&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-Casirivimab_(casirivimab)_and_imdevimab_(imdevimab)-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-Casirivimab_(casirivimab)_and_imdevimab_(imdevimab)_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://covid-vaccine.canada.ca/casirivimab-and-imdevimab/product-details">"Casirivimab (casirivimab) and imdevimab (imdevimab)"</a>. <i><a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a></i>. 9 June 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211203063003/https://covid-vaccine.canada.ca/casirivimab-and-imdevimab/product-details">Archived</a> from the original on 3 December 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">20 December</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Health+Canada&rft.atitle=Casirivimab+%28casirivimab%29+and+imdevimab+%28imdevimab%29&rft.date=2021-06-09&rft_id=https%3A%2F%2Fcovid-vaccine.canada.ca%2Fcasirivimab-and-imdevimab%2Fproduct-details&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00537&lang=en">"Summary Basis of Decision (SBD) for Casirivimab and Imdevimab"</a>. <i><a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a></i>. 23 October 2014. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220529225637/https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00537&lang=en">Archived</a> from the original on 29 May 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">29 May</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Health+Canada&rft.atitle=Summary+Basis+of+Decision+%28SBD%29+for+Casirivimab+and+Imdevimab&rft.date=2014-10-23&rft_id=https%3A%2F%2Fhpr-rps.hres.ca%2Freg-content%2Fsummary-basis-decision-detailTwo.php%3FlinkID%3DSBD00537%26lang%3Den&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-Ronapreve_SmPC-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-Ronapreve_SmPC_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Ronapreve_SmPC_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.gov.uk/government/publications/regulatory-approval-of-ronapreve/summary-of-product-characteristics-for-ronapreve">"Summary of Product Characteristics for Ronapreve"</a>. <a href="/wiki/Medicines_and_Healthcare_products_Regulatory_Agency" title="Medicines and Healthcare products Regulatory Agency">Medicines and Healthcare products Regulatory Agency</a> (MHRA). 20 August 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210830040534/https://www.gov.uk/government/publications/regulatory-approval-of-ronapreve/summary-of-product-characteristics-for-ronapreve">Archived</a> from the original on 30 August 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">29 August</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Summary+of+Product+Characteristics+for+Ronapreve&rft.pub=Medicines+and+Healthcare+products+Regulatory+Agency+%28MHRA%29&rft.date=2021-08-20&rft_id=https%3A%2F%2Fwww.gov.uk%2Fgovernment%2Fpublications%2Fregulatory-approval-of-ronapreve%2Fsummary-of-product-characteristics-for-ronapreve&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-REGEN-COV_FDA_label-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-REGEN-COV_FDA_label_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-REGEN-COV_FDA_label_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-REGEN-COV_FDA_label_8-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-REGEN-COV_FDA_label_8-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5bf7a31-7e17-4a94-805c-d231ea458fb0">"Casirivimab injection, solution, concentrate Imdevimab injection, solution, concentrate REGEN-COV – casirivimab and imdevimab kit"</a>. <i>DailyMed</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210104185039/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5bf7a31-7e17-4a94-805c-d231ea458fb0">Archived</a> from the original on 4 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">18 March</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Casirivimab+injection%2C+solution%2C+concentrate+Imdevimab+injection%2C+solution%2C+concentrate+REGEN-COV+%E2%80%93+casirivimab+and+imdevimab+kit&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3Df5bf7a31-7e17-4a94-805c-d231ea458fb0&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-FDA_PR_20201121-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_PR_20201121_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-FDA_PR_20201121_9-16"><sup><i><b>q</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19">"Coronavirus (COVID-19) Update: FDA Authorizes Monoclonal Antibodies for Treatment of COVID-19"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i> (Press release). 21 November 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210125185046/https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19">Archived</a> from the original on 25 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">21 November</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Coronavirus+%28COVID-19%29+Update%3A+FDA+Authorizes+Monoclonal+Antibodies+for+Treatment+of+COVID-19&rft.date=2020-11-21&rft_id=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Fcoronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-Ronapreve_EPAR-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-Ronapreve_EPAR_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Ronapreve_EPAR_10-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/EPAR/ronapreve">"Ronapreve EPAR"</a>. <i>European Medicines Agency</i>. 10 November 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211113183418/https://www.ema.europa.eu/en/medicines/human/EPAR/ronapreve">Archived</a> from the original on 13 November 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">12 November</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency&rft.atitle=Ronapreve+EPAR&rft.date=2021-11-10&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2FEPAR%2Fronapreve&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/human-regulatory-overview/public-health-threats/coronavirus-disease-covid-19/covid-19-medicines">"COVID-19 medicines"</a>. <i>European Medicines Agency (EMA)</i>. 14 October 2024<span class="reference-accessdate">. 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Retrieved <span class="nowrap">17 August</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=NPR&rft.atitle=Texas+Gov.+Greg+Abbott+Tests+Positive+For+The+Coronavirus&rft.date=2021-08-17&rft.aulast=Schneider&rft.aufirst=A&rft_id=https%3A%2F%2Fwww.npr.org%2Fsections%2Fcoronavirus-live-updates%2F2021%2F08%2F17%2F1028574761%2Ftexas-governor-greg-abbott-tests-positive-covid-19-coronavirus&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-29">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation news cs1"><a rel="nofollow" class="external text" href="https://www.reuters.com/article/us-health-coronavirus-usa-regeneron-phar-idUSKBN29H2ZY">"U.S. to buy 1.25 million additional doses of Regeneron's COVID-19 antibody cocktail"</a>. <i>Reuters</i>. 12 January 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211013072027/https://www.reuters.com/article/us-health-coronavirus-usa-regeneron-phar-idUSKBN29H2ZY">Archived</a> from the original on 13 October 2021<span class="reference-accessdate">. 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Retrieved <span class="nowrap">19 March</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Regeneron+Pharmaceuticals&rft.atitle=Casirivimab+and+Imdevimab&rft_id=https%3A%2F%2Fwww.regeneron.com%2Fmedicines%2Fcasirivimab-imdevimab&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-40">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/news/ema-starts-rolling-review-regn-cov2-antibody-combination-casirivimab-imdevimab">"EMA starts rolling review of REGN‑COV2 antibody combination (casirivimab / imdevimab)"</a> (Press release). <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 1 February 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210315174649/https://www.ema.europa.eu/en/news/ema-starts-rolling-review-regn-cov2-antibody-combination-casirivimab-imdevimab">Archived</a> from the original on 15 March 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">1 February</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=EMA+starts+rolling+review+of+REGN%E2%80%91COV2+antibody+combination+%28casirivimab+%2F+imdevimab%29&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2021-02-01&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fnews%2Fema-starts-rolling-review-regn-cov2-antibody-combination-casirivimab-imdevimab&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-41"><span class="mw-cite-backlink"><b><a href="#cite_ref-41">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/news/ema-reviewing-data-monoclonal-antibody-use-covid-19">"EMA reviewing data on monoclonal antibody use for COVID-19"</a> (Press release). <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 4 February 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210315174642/https://www.ema.europa.eu/en/news/ema-reviewing-data-monoclonal-antibody-use-covid-19">Archived</a> from the original on 15 March 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">4 March</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=EMA+reviewing+data+on+monoclonal+antibody+use+for+COVID-19&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2021-02-04&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fnews%2Fema-reviewing-data-monoclonal-antibody-use-covid-19&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-42"><span class="mw-cite-backlink"><b><a href="#cite_ref-42">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/news/ema-issues-advice-use-regn-cov2-antibody-combination-casirivimab-imdevimab">"EMA issues advice on use of REGN-COV2 antibody combination (casirivimab / imdevimab)"</a> (Press release). <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 26 February 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210315174643/https://www.ema.europa.eu/en/news/ema-issues-advice-use-regn-cov2-antibody-combination-casirivimab-imdevimab">Archived</a> from the original on 15 March 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">5 March</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=EMA+issues+advice+on+use+of+REGN-COV2+antibody+combination+%28casirivimab+%2F+imdevimab%29&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2021-02-26&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fnews%2Fema-issues-advice-use-regn-cov2-antibody-combination-casirivimab-imdevimab&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-43"><span class="mw-cite-backlink"><b><a href="#cite_ref-43">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://timesofindia.indiatimes.com/india/india-approves-roche/regeneron-antibody-cocktail-to-treat-covid-19/articleshow/82407551.cms">"India approves Roche/Regeneron antibody cocktail to treat Covid-19 – India News"</a>. <i>The Times of India</i>. 5 May 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210526230115/https://timesofindia.indiatimes.com/india/india-approves-roche/regeneron-antibody-cocktail-to-treat-covid-19/articleshow/82407551.cms">Archived</a> from the original on 26 May 2021<span class="reference-accessdate">. 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Retrieved <span class="nowrap">4 October</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.recoverytrial.net&rft.atitle=RECOVERY+trial+finds+Regeneron%27s+monoclonal+antibody+combination+reduces+deaths+for+hospitalised+COVID-19+patients+who+have+not+mounted+their+own+immune+response+%E2%80%94+RECOVERY+Trial&rft_id=https%3A%2F%2Fwww.recoverytrial.net%2Fnews%2Frecovery-trial-finds-regeneron2019s-monoclonal-antibody-combination-reduces-deaths-for-hospitalised-covid-19-patients-who-have-not-mounted-their-own-immune-response-1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-50">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation news cs1"><a rel="nofollow" class="external text" href="https://www.bbc.com/news/health-57488150">"Another life-saving Covid treatment found"</a>. <i>BBC News</i>. 16 June 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20211004050558/https://www.bbc.com/news/health-57488150">Archived</a> from the original on 4 October 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">4 October</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BBC+News&rft.atitle=Another+life-saving+Covid+treatment+found&rft.date=2021-06-16&rft_id=https%3A%2F%2Fwww.bbc.com%2Fnews%2Fhealth-57488150&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> <li id="cite_note-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-51">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.recoverytrial.net/news/recovery-covid-19-phase-3-trial-to-evaluate-regeneron2019s-regn-cov2-investigational-antibody-cocktail-in-the-uk">"RECOVERY COVID-19 phase 3 trial to evaluate Regeneron's REGN-COV2 investigational antibody cocktail in the UK"</a>. <i>Recovery Trial</i>. 14 September 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210121142018/https://www.recoverytrial.net/news/recovery-covid-19-phase-3-trial-to-evaluate-regeneron2019s-regn-cov2-investigational-antibody-cocktail-in-the-uk">Archived</a> from the original on 21 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">14 September</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Recovery+Trial&rft.atitle=RECOVERY+COVID-19+phase+3+trial+to+evaluate+Regeneron%27s+REGN-COV2+investigational+antibody+cocktail+in+the+UK&rft.date=2020-09-14&rft_id=https%3A%2F%2Fwww.recoverytrial.net%2Fnews%2Frecovery-covid-19-phase-3-trial-to-evaluate-regeneron2019s-regn-cov2-investigational-antibody-cocktail-in-the-uk&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=10" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'BrienForleo-NetoMusserIsa2021" class="citation journal cs1">O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, et al. (September 2021). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa2109682">"Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19"</a>. <i>N Engl J Med</i>. <b>385</b> (13): <span class="nowrap">1184–</span>1195. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa2109682">10.1056/NEJMoa2109682</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362593">8362593</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34347950">34347950</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=N+Engl+J+Med&rft.atitle=Subcutaneous+REGEN-COV+Antibody+Combination+to+Prevent+Covid-19&rft.volume=385&rft.issue=13&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1184-%3C%2Fspan%3E1195&rft.date=2021-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8362593%23id-name%3DPMC&rft_id=info%3Apmid%2F34347950&rft_id=info%3Adoi%2F10.1056%2FNEJMoa2109682&rft.aulast=O%27Brien&rft.aufirst=MP&rft.au=Forleo-Neto%2C+E&rft.au=Musser%2C+BJ&rft.au=Isa%2C+F&rft.au=Chan%2C+KC&rft.au=Sarkar%2C+N&rft.au=Bar%2C+KJ&rft.au=Barnabas%2C+RV&rft.au=Barouch%2C+DH&rft.au=Cohen%2C+MS&rft.au=Hurt%2C+CB&rft.au=Burwen%2C+DR&rft.au=Marovich%2C+MA&rft.au=Hou%2C+P&rft.au=Heirman%2C+I&rft.au=Davis%2C+JD&rft.au=Turner%2C+KC&rft.au=Ramesh%2C+D&rft.au=Mahmood%2C+A&rft.au=Hooper%2C+AT&rft.au=Hamilton%2C+JD&rft.au=Kim%2C+Y&rft.au=Purcell%2C+LA&rft.au=Baum%2C+A&rft.au=Kyratsous%2C+CA&rft.au=Krainson%2C+J&rft.au=Perez-Perez%2C+R&rft.au=Mohseni%2C+R&rft.au=Kowal%2C+B&rft.au=DiCioccio%2C+AT&rft.au=Stahl%2C+N&rft.au=Lipsich%2C+L&rft.au=Braunstein%2C+N&rft.au=Herman%2C+G&rft.au=Yancopoulos%2C+GD&rft.au=Weinreich%2C+DM&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa2109682&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Casirivimab/imdevimab&action=edit&section=11" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1235681985">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:var(--background-color-interactive-subtle,#f8f9fa);display:flow-root}.mw-parser-output .side-box-abovebelow,.mw-parser-output .side-box-text{padding:0.25em 0.9em}.mw-parser-output .side-box-image{padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .side-box-imageright{padding:2px 0.9em 2px 0;text-align:center}@media(min-width:500px){.mw-parser-output .side-box-flex{display:flex;align-items:center}.mw-parser-output .side-box-text{flex:1;min-width:0}}@media(min-width:720px){.mw-parser-output .side-box{width:238px}.mw-parser-output .side-box-right{clear:right;float:right;margin-left:1em}.mw-parser-output .side-box-left{margin-right:1em}}</style><style data-mw-deduplicate="TemplateStyles:r1237033735">@media print{body.ns-0 .mw-parser-output .sistersitebox{display:none!important}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}</style><div class="side-box side-box-right plainlinks sistersitebox"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"> <div class="side-box-flex"> <div class="side-box-image"><span class="noviewer" typeof="mw:File"><a href="/wiki/File:Commons-logo.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png" decoding="async" width="30" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/45px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/59px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span></div> <div class="side-box-text plainlist">Wikimedia Commons has media related to <span style="font-weight: bold; font-style: italic;"><a href="https://commons.wikimedia.org/wiki/Category:Casirivimab/imdevimab" class="extiw" title="commons:Category:Casirivimab/imdevimab">Casirivimab/imdevimab</a></span>.</div></div> </div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/media/143891/download">"Casirivimab and Imdevimab EUA Letter of Authorization"</a> <span class="cs1-format">(PDF)</span>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Casirivimab+and+Imdevimab+EUA+Letter+of+Authorization&rft_id=https%3A%2F%2Fwww.fda.gov%2Fmedia%2F143891%2Fdownload&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/media/143894/download">"Frequently Asked Questions on the Emergency Use Authorization of Casirivimab + Imdevimab"</a> <span class="cs1-format">(PDF)</span>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Frequently+Asked+Questions+on+the+Emergency+Use+Authorization+of+Casirivimab+%2B+Imdevimab&rft_id=https%3A%2F%2Fwww.fda.gov%2Fmedia%2F143894%2Fdownload&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACasirivimab%2Fimdevimab" class="Z3988"></span></li> <li>Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/show/NCT04426695">NCT04426695</a></i> for "Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19" at <a href="/wiki/ClinicalTrials.gov" title="ClinicalTrials.gov">ClinicalTrials.gov</a></li> <li>Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/show/NCT04425629">NCT04425629</a></i> for "Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19" at <a href="/wiki/ClinicalTrials.gov" title="ClinicalTrials.gov">ClinicalTrials.gov</a></li> <li>Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/show/NCT04452318">NCT04452318</a></i> for "COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household Contacts to an Individual With a Positive SARS-CoV-2 RT-PCR Assay" at <a href="/wiki/ClinicalTrials.gov" title="ClinicalTrials.gov">ClinicalTrials.gov</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist 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abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Immune_sera_and_immunoglobulins" title="Template:Immune sera and immunoglobulins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Immune_sera_and_immunoglobulins" title="Template talk:Immune sera and immunoglobulins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Immune_sera_and_immunoglobulins" title="Special:EditPage/Template:Immune sera and immunoglobulins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Immune_sera_and_immunoglobulins_(J06)124" style="font-size:114%;margin:0 4em">Immune sera and immunoglobulins (<a href="/wiki/ATC_code_J06" title="ATC code J06">J06</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polyclonal_antibodies" title="Polyclonal antibodies">Polyclonal antibodies</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Intravenous_immunoglobulin" class="mw-redirect" title="Intravenous immunoglobulin">IVIG</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anthrax_immune_globulin" title="Anthrax immune globulin">Anthrax immune globulin</a></li> <li><a href="/wiki/Rho(D)_immune_globulin" title="Rho(D) immune globulin">Rho(D) immune globulin</a></li> <li><a href="/wiki/Hepatitis_B_immune_globulin" title="Hepatitis B immune globulin">Hepatitis B immune globulin</a></li> <li><a href="/wiki/Zoster-immune_globulin" class="mw-redirect" title="Zoster-immune globulin">Zoster-immune globulin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antiserum" title="Antiserum">Antiserum</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Antivenom" title="Antivenom">Antivenom</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibodies</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bezlotoxumab" title="Bezlotoxumab">Bezlotoxumab</a></li> <li><a href="/wiki/Motavizumab" title="Motavizumab">Motavizumab</a></li> <li><a href="/wiki/Nebacumab" title="Nebacumab">Nebacumab</a></li> <li><a href="/wiki/Nirsevimab" title="Nirsevimab">Nirsevimab</a></li> <li><a href="/wiki/Obiltoxaximab" title="Obiltoxaximab">Obiltoxaximab</a></li> <li><a href="/wiki/Palivizumab" title="Palivizumab">Palivizumab</a></li> <li><a href="/wiki/Raxibacumab" title="Raxibacumab">Raxibacumab</a></li> <li><a href="/wiki/Sipavibart" title="Sipavibart">Sipavibart</a></li> <li><a href="/wiki/Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">Tixagevimab/cilgavimab</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-labelledby="Monoclonal_antibodies_for_infectious_disease_and_toxins438" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Monoclonals_for_infectious_disease_and_toxins" title="Template:Monoclonals for infectious disease and toxins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Monoclonals_for_infectious_disease_and_toxins" title="Template talk:Monoclonals for infectious disease and toxins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Monoclonals_for_infectious_disease_and_toxins" title="Special:EditPage/Template:Monoclonals for infectious disease and toxins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Monoclonal_antibodies_for_infectious_disease_and_toxins438" style="font-size:114%;margin:0 4em"><a href="/wiki/Monoclonal_antibodies" class="mw-redirect" title="Monoclonal antibodies">Monoclonal antibodies</a> for <a href="/wiki/Infectious_disease" class="mw-redirect" title="Infectious disease">infectious disease</a> and <a href="/wiki/Toxin" title="Toxin">toxins</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fungal" class="mw-redirect" title="Fungal">Fungal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Human5" scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Efungumab" title="Efungumab">Efungumab</a><sup>†</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Virus" title="Virus">Viral</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ansuvimab" title="Ansuvimab">Ansuvimab</a></li> <li><a href="/wiki/Atoltivimab" title="Atoltivimab">Atoltivimab</a> (<a href="/wiki/Atoltivimab/maftivimab/odesivimab" title="Atoltivimab/maftivimab/odesivimab">+maftivimab/odesivimab</a>)</li> <li><a href="/w/index.php?title=Avdoralimab&action=edit&redlink=1" class="new" title="Avdoralimab (page does not exist)">Avdoralimab</a><sup>§</sup></li> <li><a href="/wiki/Bamlanivimab" title="Bamlanivimab">Bamlanivimab</a><sup>†</sup> (<a href="/wiki/Bamlanivimab/etesevimab" title="Bamlanivimab/etesevimab">+etesevimab</a>)<sup>†</sup></li> <li><a href="/wiki/Bebtelovimab" title="Bebtelovimab">Bebtelovimab</a><sup>§</sup></li> <li><a href="/wiki/Casirivimab" class="mw-redirect" title="Casirivimab">Casirivimab</a><sup>†</sup> (<a class="mw-selflink selflink">+imdevimab</a>)</li> <li><a href="/wiki/Cilgavimab" class="mw-redirect" title="Cilgavimab">Cilgavimab</a><sup>†</sup> (<a href="/wiki/Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">+tixagevimab</a>)<sup>†</sup></li> <li><a href="/wiki/Diridavumab" title="Diridavumab">Diridavumab</a><sup>§</sup></li> <li><a href="/wiki/Etesevimab" class="mw-redirect" title="Etesevimab">Etesevimab</a><sup>†</sup></li> <li><a href="/wiki/Exbivirumab" title="Exbivirumab">Exbivirumab</a><sup>§</sup></li> <li><a href="/wiki/Foravirumab" title="Foravirumab">Foravirumab</a><sup>§</sup></li> <li><a href="/wiki/Imdevimab" class="mw-redirect" title="Imdevimab">Imdevimab</a><sup>†</sup> (<a class="mw-selflink selflink">+casirivimab</a>)</li> <li><a href="/wiki/Libivirumab" title="Libivirumab">Libivirumab</a><sup>§</sup></li> <li><a href="/wiki/Maftivimab" title="Maftivimab">Maftivimab</a></li> <li><a href="/wiki/Nirsevimab" title="Nirsevimab">Nirsevimab</a><sup>†</sup></li> <li><a href="/wiki/Odesivimab" title="Odesivimab">Odesivimab</a></li> <li><a href="/wiki/Pemivibart" title="Pemivibart">Pemivibart</a></li> <li><a href="/wiki/Rafivirumab" title="Rafivirumab">Rafivirumab</a><sup>§</sup></li> <li><a href="/wiki/Regavirumab" title="Regavirumab">Regavirumab</a><sup>§</sup></li> <li><a href="/wiki/Regdanvimab" title="Regdanvimab">Regdanvimab</a></li> <li><a href="/wiki/Sevirumab" title="Sevirumab">Sevirumab</a><sup>†</sup></li> <li><a href="/wiki/Sipavibart" title="Sipavibart">Sipavibart</a></li> <li><a href="/wiki/Sotrovimab" title="Sotrovimab">Sotrovimab</a></li> <li><a href="/wiki/Suptavumab" title="Suptavumab">Suptavumab</a></li> <li><a href="/wiki/Tixagevimab" class="mw-redirect" title="Tixagevimab">Tixagevimab</a><sup>†</sup> (<a href="/wiki/Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">+cilgavimab</a>)<sup>†</sup></li> <li><a href="/wiki/Tuvirumab" title="Tuvirumab">Tuvirumab</a><sup>§</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chimeric_antibody" class="mw-redirect" title="Chimeric antibody">Chimeric</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ZMapp" title="ZMapp">Cosfroviximab</a></li> <li><a href="/wiki/ZMapp" title="ZMapp">Larcaviximab</a></li> <li><a href="/wiki/ZMapp" title="ZMapp">Porgaviximab</a></li> <li><a href="/wiki/Vilobelimab" title="Vilobelimab">Vilobelimab</a><sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Humanized_antibody" title="Humanized antibody">Humanized</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Felvizumab" title="Felvizumab">Felvizumab</a><sup>§</sup></li> <li><a href="/wiki/Lenvervimab" title="Lenvervimab">Lenvervimab</a><sup>†</sup></li> <li><a href="/wiki/Motavizumab" title="Motavizumab">Motavizumab</a><sup>†</sup></li> <li><a href="/wiki/Palivizumab" title="Palivizumab">Palivizumab</a></li> <li><a href="/wiki/Suvizumab" title="Suvizumab">Suvizumab</a><sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacterial" class="mw-redirect" title="Bacterial">Bacterial</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nebacumab" title="Nebacumab">Nebacumab</a></li> <li><a href="/wiki/Panobacumab" title="Panobacumab">Panobacumab</a><sup>§</sup></li> <li><a href="/wiki/Raxibacumab" title="Raxibacumab">Raxibacumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Mouse</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Edobacomab" title="Edobacomab">Edobacomab</a><sup>§</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chimeric_antibody" class="mw-redirect" title="Chimeric antibody">Chimeric</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pagibaximab" title="Pagibaximab">Pagibaximab</a><sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Humanized</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tefibazumab" title="Tefibazumab">Tefibazumab</a><sup>†</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Toxin" title="Toxin">Toxin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Actoxumab" title="Actoxumab">Actoxumab</a><sup>§</sup></li> <li><a href="/wiki/Bezlotoxumab" title="Bezlotoxumab">Bezlotoxumab</a></li> <li><a href="/wiki/Suvratoxumab" title="Suvratoxumab">Suvratoxumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Chimeric</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Obiltoxaximab" title="Obiltoxaximab">Obiltoxaximab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Humanized</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Urtoxazumab" title="Urtoxazumab">Urtoxazumab</a><sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" 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