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Alnylam & RNAi | Resources to understand how Alnylam鈥檚 RNAi-based medicines work
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in</a> </li> </ul> </nav> <span class="menu-separator">|</span> <nav class="signup-menu-wrapper"> <ul class="al-menu-signup menu"> <li class="menu-item"> <a href="/user/register" data-drupal-link-system-path="user/register">Sign Up</a> </li> </ul> </nav> </div> </div> </div> </nav> </div> <div class="row"> <div class="top-content col-12"> <div class="region region-content"> <div id="block-alnylam-breadcrumbs" class="block block-system block-system-breadcrumb-block"> </div> <div id="block-alnylam-content" class="block block-system block-system-main-block"> <article about="/alnylam-rnai" class="node node--type-generic node--promoted node--view-mode-full"> <div class="node__content"> <h1><span class="field field--name-title field--type-string field--label-hidden">Alnylam & RNAi</span> </h1> <div class="meta"> </div> <div class="field field--name-field-modules field--type-entity-reference-revisions field--label-hidden field__items"> <div class="bundle-general-text-section field__item"> <div class="general-text-section paragraph paragraph--type--general-text-section paragraph--view-mode--default color--default"> <div class="clearfix text-formatted field field--name-field-general-text-section-text field--type-text-with-summary field--label-hidden field__item"><p>Explore a library of educational resources about RNA interference (RNAi), the science behind Alnylam's FDA-approved products and clinical pipeline, and find out more about our small interfering RNA (siRNA) delivery platforms.</p></div> </div> </div> <div class="bundle-full-width-image field__item"> <div class="hero paragraph paragraph--type--full-width-image paragraph--view-mode--default"> <div class="full-width-image"> <div class="image"> <div class="desktop"> <img src="https://www.rnaiscience.com/sites/default/files/styles/webp/public/2024-02/mrna-protein-synthesis.png.webp?itok=h60htjar" alt="Ribosome making disease-causing protein with mRNA" loading="lazy"> </div> <div class="mobile"> <img src="https://www.rnaiscience.com/sites/default/files/styles/webp/public/2024-03/mrna-protein-synthesis-mobile.jpg.webp?itok=sDhlLGj2" alt="Ribosome making disease-causing protein with mRNA" loading="lazy"> </div> </div> </div> </div> </div> <div class="bundle-accordion field__item"> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default accordion-wrapper"> <div class="expand-wrapper"> <a href="#" class="expand-all" role="button">Expand All</a> <a href="#" class="collapse-all" style="display:none;" role="button">Collapse All</a> </div> <div class="accordion"> <div class="paragraph paragraph--type--accordion-section paragraph--view-mode--default accordion-item"> <div id="46"> <p class="accordion-header" id="panelsStayOpen-headingOne-46"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#panelsStayOpen-collapseOne-46" aria-expanded="false" aria-controls="panelsStayOpen-collapseOne"> <div class="clearfix text-formatted field field--name-field-heading field--type-text-long field--label-hidden field__item"><h2>Science of RNAi </h2></div> </button> </p> </div> <div id="panelsStayOpen-collapseOne-46" class="accordion-collapse collapse" aria-labelledby="panelsStayOpen-headingOne-46"> <div class="accordion-body"> <div class="field field--name-field-accordion-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="bundle-general-text-section field__item"> <div class="general-text-section paragraph paragraph--type--general-text-section paragraph--view-mode--default color--default"> <div class="clearfix text-formatted field field--name-field-general-text-section-text field--type-text-with-summary field--label-hidden field__item"><p>Click on the links below to learn more about how RNAi can be used to "silence" gene expression and the production of proteins that cause or contribute to disease.</p></div> </div> </div> <div class="bundle-left-image-right-text field__item"> <div class="paragraph paragraph--type--left-image-right-text paragraph--view-mode--default"> <div class="left"> <div class="field field--name-field-left-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-default"> <div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/default/files/styles/webp/public/2024-02/presentation-about-RNAi-science.jpg.webp?itok=uOSEPM_F" width="174" height="152" alt="Icon of PPT file" typeof="foaf:Image" class="image-style-webp" /> </div> </div> </article> </div> </div> <div class="right"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> <div class="clearfix text-formatted field field--name-field-right-text field--type-text-long field--label-hidden field__item"><h3><a href="/sites/default/files/2024-02/DZSTATE_MA_The%20Science%20of%20RNAi_MED-US-DZSTATE-2300011.pdf" target="_blank" data-entity-type="media" data-entity-uuid="d934d85d-28c1-4978-8f64-c84c0a1eea6d" data-entity-substitution="media">The Science of RNAi</a></h3><p dir="ltr">An overview of RNA interference therapy and RISC-mediated RNA cleavage.</p></div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion-section paragraph--view-mode--default accordion-item"> <div id="MOA"> <p class="accordion-header" id="panelsStayOpen-headingOne-47"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#panelsStayOpen-collapseOne-47" aria-expanded="false" aria-controls="panelsStayOpen-collapseOne"> <div class="clearfix text-formatted field field--name-field-heading field--type-text-long field--label-hidden field__item"><h2>Mechanism of action</h2></div> </button> </p> </div> <div id="panelsStayOpen-collapseOne-47" class="accordion-collapse collapse" aria-labelledby="panelsStayOpen-headingOne-47"> <div class="accordion-body"> <div class="field field--name-field-accordion-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="bundle-left-image-right-text field__item"> <div class="paragraph paragraph--type--left-image-right-text paragraph--view-mode--default"> <div class="left"> <div class="field field--name-field-left-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-default"> <div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/default/files/styles/webp/public/2024-03/video-about-RNAi-science.jpg.webp?itok=FWZtcupR" width="212" height="212" alt="Icon of video player" typeof="foaf:Image" class="image-style-webp" /> </div> </div> </article> </div> </div> <div class="right"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> <div class="clearfix text-formatted field field--name-field-right-text field--type-text-long field--label-hidden field__item"><h3><a class="no-speedbump" href="https://player.vimeo.com/video/928578815?h=9d41aa75ea&badge=0&autopause=0&player_id=0&app_id=58479">RNAi Therapeutics: How Do They Work?</a></h3><p dir="ltr">This video highlights the MOA of RNAi therapeutics, and how small interfering RNA (siRNA) short oligonucleotides are used to harness the RNA-induced silencing complex (RISC) to silence gene expression. This resource is intended to be viewed in its entirety to support scientific exchange and is not intended as recommendations for clinical practice. For further information, please see RNAiScience.com to connect with a Medical Science Liaison, submit a medical information request, or access other Alnylam medical education resources.</p></div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion-section paragraph--view-mode--default accordion-item"> <div id="48"> <p class="accordion-header" id="panelsStayOpen-headingOne-48"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#panelsStayOpen-collapseOne-48" aria-expanded="false" aria-controls="panelsStayOpen-collapseOne"> <div class="clearfix text-formatted field field--name-field-heading field--type-text-long field--label-hidden field__item"><h2>Delivery</h2></div> </button> </p> </div> <div id="panelsStayOpen-collapseOne-48" class="accordion-collapse collapse" aria-labelledby="panelsStayOpen-headingOne-48"> <div class="accordion-body"> <div class="field field--name-field-accordion-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="bundle-general-text-section field__item"> <div class="general-text-section paragraph paragraph--type--general-text-section paragraph--view-mode--default color--default"> <div class="clearfix text-formatted field field--name-field-general-text-section-text field--type-text-with-summary field--label-hidden field__item"><p>Click below to learn about how different siRNA delivery platforms work.</p></div> </div> </div> <div class="bundle-information field__item"> <div class="information paragraph paragraph--type--information paragraph--view-mode--default"> <div class="content"> <div class="text"> <a href=https://doi.org/10.1093/nar/gkaa670 class="information-link"> <div class="clearfix text-formatted field field--name-field-information-text field--type-text-long field--label-hidden field__item"><p>Investigating the pharmacodynamic durability of GalNAc鈥搒iRNA conjugates</p></div> </a> </div> <div class="information-lines"> <div class="field field--name-field-information-lines field--type-entity-reference-revisions field--label-hidden field__items"> <div class="bundle-information-line field__item"> <div class="information-line"> <div class="left"> <p>Publication Date</p> </div> <div class="right"> <p>Dec 2, 2020</p> </div> </div> </div> <div class="bundle-information-line field__item"> <div class="information-line"> <div class="left"> <p>Journal</p> </div> <div class="right"> <p>Nucleic Acids Res.</p> </div> </div> </div> <div class="bundle-information-line field__item"> <div class="information-line"> <div class="left"> <p>Authors</p> </div> <div class="right"> <p>Brown CR, Gupta S, Qin J et al. </p> </div> </div> </div> </div> </div> <div class="footer"> </div> </div> </div> </div> <div class="bundle-general-text-section field__item"> <div class="general-text-section paragraph paragraph--type--general-text-section paragraph--view-mode--default color--default"> <div class="clearfix text-formatted field field--name-field-general-text-section-text field--type-text-with-summary field--label-hidden field__item"><p><a href="https://www.alnylam.com/our-science/sirna-delivery-platforms"><strong>Click here</strong></a> to learn more about how Alnylam is optimizing RNAi delivery.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </div> <footer class="desktop-footer col-12 d-none d-xl-block" role="contentinfo"> <div class="block-content block-content--type-footer-content block-content--9 block-content--view-mode-full"> <div class="block-content__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This site is intended for US healthcare professionals.<br>漏 2024 Alnylam Pharmaceuticals, Inc. 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