CINXE.COM

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Ethos</a></li> <li class="leaf"><a href="/about-tocris/environment" id="main-menu-13876">Environment</a></li> <li class="last leaf"><a href="/about-tocris/careers-at-tocris" id="main-menu-13846">Careers</a></li> </ul></li> <li class="last leaf"><a href="/support/contact-us" id="main-menu-7501">Contact Us</a></li> </ul> </section> </div> </nav> </div> </header> <div class="breadcrumbs_wrapper"> <div class="breadcrumbs_container"> <div class="breadcrumb"><a href="/">Home</a> <span class="breadcrumb_separator">/</span> <a href="/services" class="active-trail">Services</a> <span class="breadcrumb_separator">/</span> Tocriscreen™ PRO Custom Compound Library Service</div> </div> </div> <div class="main-container container"> <div class="row"> <section> <a id="main-content"></a> <div class="col-xs-12 col-sm-8 col-md-9"> <h1>Tocriscreen™ PRO Custom Compound Library Service</h1> <h2></h2><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><div class="row"> <div class="col-md-10"> <p>The Tocriscreen™ PRO service allows you to design a completely custom compound library to meet your exact screening requirements. With this cherry-picking service, you can choose compounds from a list over 3,000 products from the Tocris catalog (minimum order ~80 wet or 30 dry compounds), as well as customize the format of the compounds (dry powder or in solution), and the tubes they are supplied in.</p> </div> <div class="col-md-2"> <div class="visible-sm visible-xs" style="font-size:15px; line-height:15px;"> </div> <img alt="" src="https://resources.tocris.com/images/targets/tocriscreen-pro-customized-icon.png" /> <div style="font-size:15px; line-height:15px;"> </div> </div> </div> <div class="row"> <div class="col-md-10"> <p>The bioactive compounds available through the Tocriscreen PRO service cover a wide range of targets, such as GPCRs, ion channels, enzymes, kinases, nuclear receptors and transporters, and all major research areas and product actions. Included are commonly used research standards, novel research tools, and pharmacologically active components of FDA-approved therapeutics.</p> </div> <div class="col-md-2"> <div class="visible-sm visible-xs" style="font-size:15px; line-height:15px;"> </div> <img alt="" src="https://resources.tocris.com/images/targets/tocriscreen-pro-diverse-range-icon.png" /></div> <div style="font-size:15px; line-height:15px;"> </div> </div> <p>As well as requesting a completely custom library, the Tocriscreen PRO service also allows you to select a pre-defined list of compounds. Currently available lists are:</p> <ul style="padding-left:1em;"> <li><strong>COVID-19 Compounds</strong> – this list is comprised of key targets within the SARS-CoV-2 viral life cycle and compounds that have been linked to coronaviruses in the scientific literature. The library is available in 10 mM DMSO solution (50 μL - 1 mL) or as dry powder (2 - 10 mg).</li> <li><strong>Additional New Products</strong> – If you previously purchased the <a href="/products/tocriscreen-plus_5840" target="_blank">Tocriscreen Plus</a>, <a href="/products/tocriscreen-plus-mini_5841" target="_blank">Plus Mini</a> or <a href="/products/tocriscreen-plus-micro_6455" target="_blank">Plus Micro</a> Compound Libraries (Cat. Nos. 5840, 5481 and 6455, respectively), you can upgrade your library by adding the latest new products included in the <a href="/products/tocriscreen-2-0-max_7150" target="_blank">Tocriscreen 2.0 Max</a>, <a href="/products/tocriscreen-2-0-mini_7151" target="_blank">Tocriscreen 2.0 Mini</a> and <a href="/products/tocriscreen-2-0-micro_7152" target="_blank">Tocriscreen 2.0 Micro</a> (Cat. Nos. 7150, 7151 and 7152 respectively). These compounds are supplied pre-dissolved in 10 mM DMSO.</li> </ul> <p> </p> <p>The Tocris scientific team are ready to help you with choosing compounds and designing your bioactive compound library to fit your research needs. To help our team get started on your inquiry, please provide as much information as possible about your required compound format, research areas and targets, and if you require one of the pre-defined lists outlined above.</p> <p>Please submit your requirements through the <a href="/support/screening-inquiry" target="_blank"><strong>compound library inquiry form</strong></a>.</p> <p> </p> <p><img alt="Customize your compound library" src="https://resources.tocris.com/images/targets/tocriscreen-pro-flow-diagram.png" style="max-width:100%;" /></p> <p> </p> <h2>Major Research Areas Covered By Tocriscreen PRO</h2> <p><img alt="Major research areas covered by the Tocriscreen PRO" src="https://resources.tocris.com/images/targets/tocriscreen-pro-research-areas2.png" style="max-width:100%;" /></p> <p>The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of biomedical research areas; neuroscience (36%), cancer (34%), endocrinology (9%), immunology (8%), cardiovascular (6%), stem cells (5%), other research areas (3%).</p> <p> </p> <h2>Major Target Classes Covered By Tocriscreen PRO</h2> <p><img alt="Major target classes covered by the Tocriscreen PRO" src="https://resources.tocris.com/images/targets/tocriscreen-pro-target-classes2.png" style="max-width:100%;" /></p> <p>The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 24%), non-kinase enzymes (23%), kinases including enzyme-linked receptors (19%), ion channels (13%), cell biology targets (10%), nuclear receptors (5%), and transporters and other pharmacological targets (5%).</p> <p> </p> <h2>Citations</h2> <p><strong>Danish</strong> <em>et al</em> (2021) <a href="https://pubmed.ncbi.nlm.nih.gov/33572565/" rel="nofollow" target="_blank">A cellular assay for the identification and characterization of connexin gap junction modulators.</a> Int.J.Mol.Sci. <strong><em>22</em></strong> 1417 PMID: 33572565 </p> <p><strong>Wazir </strong><em>et al</em> (2021) <a href="https://pubmed.ncbi.nlm.nih.gov/32527186/" rel="nofollow" target="_blank">Activity-based screening assay for mono-ADP-ribosylhydrolases.</a> SLAS Discov. <strong><em>26</em></strong> 67 PMID: 32527186</p> <p><strong>Yoon</strong> <em>et al</em> (2020) <a href="https://pubmed.ncbi.nlm.nih.gov/31964466/" rel="nofollow" target="_blank">Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles. </a>BMB Rep. <strong><em>53</em></strong> 166 PMID: 31964466</p> <p><strong>Duvall</strong><strong> </strong><em>et al</em> (2019) <a href="https://pubmed.ncbi.nlm.nih.gov/30735632/" rel="nofollow" target="_blank">Small-molecule agonists of Ae. aegypti neuropeptide Y receptor block mosquito biting.</a> Cell. <strong><em>176</em></strong> 687 PMID: 30735632</p> <p><strong>Fiedler</strong> <em>et al</em> (2019) <a href="https://pubmed.ncbi.nlm.nih.gov/30853557/" rel="nofollow" target="_blank">MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size </a><a href="https://pubmed.ncbi.nlm.nih.gov/30853557/" rel="nofollow" target="_blank"><em>in vivo</em></a>. Cell Stem Cell. <strong><em>24</em></strong> 579 PMID: 30853557 </p> <p><strong>Takeuchi</strong> <em>et al</em> (2019) <a href="https://pubmed.ncbi.nlm.nih.gov/30779774/" rel="nofollow" target="_blank">Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.</a> PLoS One. <strong><em>14</em></strong> e0212233 PMID: 30779774</p> <p><strong>Mishra</strong> <em>et al</em> (2022) <a href="https://pubmed.ncbi.nlm.nih.gov/35402072/" rel="nofollow" target="_blank">Improved loss-of-function CRISPR/Cas9 genome editing in human cells concomitant with inhibition of TGFβ signaling</a>. Molecular Therapy: Nucleic Acid. <strong>28 </strong> 202 PMID: 35402072 </p> <p><strong>Jang </strong><em>et al </em>(2018)<a href="https://pubmed.ncbi.nlm.nih.gov/30282713/" rel="nofollow" target="_blank"> Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function</a>. J.Virol <strong>92 </strong>e01441 PMID: 30282713</p> <p><strong>Heins-Marroquin</strong> <em>et al</em> (2019) <a href="https://pubmed.ncbi.nlm.nih.gov/32954262/" rel="nofollow" target="_blank">Phenotypic assays in yeast and zebrafish reveal drugs that rescue <em>ATP13A2</em> deficiency. Brain.Commun.</a> <strong>1 </strong>fcz019 PMID: 32954262</p> <p><strong>McBrinn </strong><em>et al </em>(2018) <a href="https://pubmed.ncbi.nlm.nih.gov/31368510/" rel="nofollow" target="_blank">Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function.</a> Br.J.Pharmacol. <strong>176 </strong>4521 PMID: 31368510</p> <p><strong>Cheng </strong><em>et al </em>(2022) <a href="https://pubmed.ncbi.nlm.nih.gov/35258332/" rel="nofollow" target="_blank">A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial type IVB secretion system.</a> mBio. <strong>13 </strong>e0024022 PMID: 35258332</p> <p><strong>Tsukamoto </strong><em>et al </em>(2018) <a href="https://pubmed.ncbi.nlm.nih.gov/29782545/" rel="nofollow" target="_blank">Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction.</a> PLoS One. <strong>13 </strong>e0197664 PMID: 29782545</p> <p><strong>Collia </strong><em>et al </em>(2018) <a href="https://pubmed.ncbi.nlm.nih.gov/28850797/" rel="nofollow" target="_blank">A rapid phenotypic whole-cell screening approach for the identification of small-molecule inhibitors that counter β-lactamase resistance in Pseudomonas aeruginosa.</a> SLAS Discov. <strong>23 </strong>55 PMID: 28850797</p> <p><strong>Zeng </strong><em>et al (</em>2021) <a href="https://pubmed.ncbi.nlm.nih.gov/34198322/" rel="nofollow" target="_blank">Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase.</a> Biochem.J. <strong>478</strong> 2405 PMID: 34198322</p> <p><strong>Canal</strong> <em>et al </em>(2021) <a href="https://pubmed.ncbi.nlm.nih.gov/34198324/" rel="nofollow" target="_blank">Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.</a> Biochem.J. <strong>478 </strong>2465 PMID: 34198324</p> <p><strong>Murer </strong><em>et al </em>(2022) <a href="https://pubmed.ncbi.nlm.nih.gov/35072124/" rel="nofollow" target="_blank">Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern.</a> Curr.Res.Virol.Sci. <strong>3 </strong>100019 PMID: 35072124</p> <p><strong>Mitsui </strong><em>et al </em>(2019) <a href="https://pubmed.ncbi.nlm.nih.gov/31289306/" rel="nofollow" target="_blank">Identification of ryuvidine as a KDM5A inhibitor.</a> Sci.Rep. <strong>9 </strong>9952 PMID: 31289306</p> <p><strong>Ghasemi </strong><em>et al </em>(2018) <a href="https://pubmed.ncbi.nlm.nih.gov/29899842/" rel="nofollow" target="_blank">High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.</a> Oncotarget <strong>9</strong> 26064 PMID: 29899842</p> <p><strong>Mirabelli </strong><em>et al </em>(2021) <a href="https://pubmed.ncbi.nlm.nih.gov/34413211/" rel="nofollow" target="_blank">Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19.</a> Proc.Natl.Acad.Sci.U.S.A. <strong>118 </strong>e2105815118 PMID: 34413211</p> <p><strong>Anerillas </strong><em>et al </em>(2022) <a href="https://pubmed.ncbi.nlm.nih.gov/36266274/" rel="nofollow" target="_blank">A BDNF-TrkB autocrine loop enhances senescent cell viability.</a> Nat.Commun. <strong>13 </strong>6228 PMID: 36266274</p> <p><strong>Harris </strong><em>et al </em>(2019) <a href="https://pubmed.ncbi.nlm.nih.gov/30799286/" rel="nofollow" target="_blank">Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion.</a> Cell Metab. <strong>29 </strong>1166 PMID: 30799286</p> <p><strong>Benítez </strong><em>et al</em><strong> </strong>(2022) <a href="https://pubmed.ncbi.nlm.nih.gov/35306933/" rel="nofollow" target="_blank">Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening.</a> J.Enzyme Inhib.Med.Chem. <strong>37 </strong>912 PMID: 35306933</p> <p><strong>Sun </strong><em>et al</em> (2012) <a href="https://pubmed.ncbi.nlm.nih.gov/22725677/" rel="nofollow" target="_blank">Structure based model for the prediction of phospholipidosis induction potential of small molecules.</a> J.Chem.Inf.Model. <strong>52</strong> 1798 PMID: 22725677</p> <p> </p> </div></div></div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3"> <div class="distributor_region"></div> </div> </section> </div> </div> <footer id="footer_wrapper" class="container-fluid"> <div id="footer_wrapper_container" class="row"> <div id="footer" class="container"> <div id="footer_container" class="row"> <nav class="footer_column footer_column_1 col-xs-12 col-sm-3"> <div class="region region-footer-column-1"> <section id="block-menu-menu-corporate-menu" class="block block-menu clearfix"> <h6 class="block-title">Corporate</h6> <ul class="menu nav"><li class="first leaf"><a 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