Cancer Metabolism Research Product Guide

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="applicable-device" content="pc,mobile" /> <meta name="description" content="Download our Cancer Metabolism Research Guide to learn more and explore the small molecule tools available from Bio-Techne to investigate cancer metabolism pathways." /> <link rel="canonical" href="https://www.bio-techne.com/resources/literature/brochure-cancer-metabolism-guide" /> <meta property="og:site_name" content="Bio-Techne" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://www.bio-techne.com/resources/literature/brochure-cancer-metabolism-guide" /> <meta property="og:image" content="https://resources.bio-techne.com/bio-techne-assets/images/brands/bio-techne-og.png" /> <meta name="product-category" content="Small Molecules" /> <meta name="brand" content="Tocris Bioscience" /> <meta name="revision-date" content="1712069583" /> <meta name="published-date" content="1692134319" /> <meta name="research-area" content="Cancer Metabolism" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <script type="application/ld+json">{ "@context": "https://schema.org", "@graph": [ { "@type": "WebPage", "@id": "https://www.bio-techne.com/resources/literature/brochure-cancer-metabolism-guide", "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bio-techne.com/" }, { "@type": "ListItem", "position": 2, "name": "Resources", "item": "https://www.bio-techne.com/resources" }, { "@type": "ListItem", "position": 3, "name": "Literature", "item": "https://www.bio-techne.com/resources/literature" } ] } } ] }</script> <meta http-equiv="x-dns-prefetch-control" content="on" /> <script type="application/ld+json" id="json-ld">{"@context":"http://schema.org","@type":"Article","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.bio-techne.com/resources/literature/brochure-cancer-metabolism-guide"},"headline":"Cancer Metabolism Brochure","description":"Cancer cells generate a large proportion of their ATP by metabolizing glucose via aerobic glycolysis, as opposed to mostly through oxidative phosphorylation (OXPHOS) in normal cells. Malignant transformation and altered metabolism go hand in hand, because the rapid increase in proliferation places increased demand on metabolic processes that cannot be met by conventional cellular metabolism. Cancer requires three crucial metabolic adaptations for rapid cell proliferation and survival: increased ATP production to fuel their high energy needs; increased biosynthesis of the three major classes of cellular building blocks, that is proteins, lipids, and nucleic acids; and an adapted redox system to counteract the increase in oxidative stress.\r\n\r\nMetabolic reprogramming has been recognized as a hallmark of cancer, owing to its fundamental role in enabling continued tumor growth and is known as the Warburg effect, after Otto Warburg who first described the phenomenon. Cancer metabolic reprogramming is associated with inactivation of tumor suppressor genes and activation of oncogenes, as well as with mutant enzyme (oncoenzyme) activity and the accumulation of tumorigenic metabolites (oncometabolites).\r\n\r\nOur Cancer Metabolism Research Product Guide reviews some of the main areas in cancer metabolism research and lists over 150 products that can be used to investigate metabolic pathways including:\r\n\r\n\r\n\tGlycolysis\r\n\tTricarboxylic acid (TCA) cycle\r\n\tLipidogenesis\r\n\t1C metabolism and nucleic acid synthesis\r\n\tDrivers of metabolic reprogramming\r\n\tpH and redox balance\r\n\r\n","image":"https://resources.bio-techne.com/bio-techne-assets/images/literature/cancer_metabolism_brochure_cover.png","author":{"@type":"Organization","name":"Bio-techne","url":"https://www.bio-techne.com/"},"publisher":{"logo":{"url":"https://resources.bio-techne.com/bio-techne-assets/images/brands/bio-techne-og.png"}},"datePublished":"2023-08-15T16:18:39-05:00","dateModified":"2024-04-02T09:53:03-05:00"}</script> <meta http-equiv="x-ua-compatible" content="ie=edge" /> <link rel="alternate" hreflang="en" href="https://www.bio-techne.com/resources/literature/brochure-cancer-metabolism-guide" /> <link rel="alternate" hreflang="zh-hans" href="https://www.bio-techne.com/cn/resources/literature/brochure-cancer-metabolism-guide" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> <link rel="preconnect" href="https://resources.tocris.com" /> <link 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<div class="highlighted"> <aside class="container section clearfix" role="complementary"> <div> </div> </aside> </div> <div id="main" class="container-fluid container-wide "> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/resources">Resources</a> </li> <li> <a href="/resources/literature">Literature</a> </li> <li> Cancer Metabolism Brochure </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div class="row"> <div class="col-md-12 text-left"> <h1 class="mt-4">Cancer Metabolism Brochure</h1> <a href="/resources/literature?tid%5B411%5D=411" class="badge-pill badge-primary 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Malignant transformation and altered metabolism go hand in hand, because the rapid increase in proliferation places increased demand on metabolic processes that cannot be met by conventional cellular metabolism. Cancer requires three crucial metabolic adaptations for rapid cell proliferation and survival: increased ATP production to fuel their high energy needs; increased biosynthesis of the three major classes of cellular building blocks, that is proteins, lipids, and nucleic acids; and an adapted redox system to counteract the increase in oxidative stress.</p> <p>Metabolic reprogramming has been recognized as a hallmark of cancer, owing to its fundamental role in enabling continued tumor growth and is known as the Warburg effect, after Otto Warburg who first described the phenomenon. Cancer metabolic reprogramming is associated with inactivation of tumor suppressor genes and activation of oncogenes, as well as with mutant enzyme (oncoenzyme) activity and the accumulation of tumorigenic metabolites (oncometabolites).</p> <p>Our Cancer Metabolism Research Product Guide reviews some of the main areas in cancer metabolism research and lists over 150 products that can be used to investigate metabolic pathways including:</p> <ul> <li>Glycolysis</li> <li>Tricarboxylic acid (TCA) cycle</li> <li>Lipidogenesis</li> <li>1C metabolism and nucleic acid synthesis</li> <li>Drivers of metabolic reprogramming</li> <li>pH and redox balance</li> </ul></div> </div> </div> <div class="col-md-6" id="marketo-component-div" data-literaturedetails="{"formId":"10693","documentID":"<a href=\"https:\/\/www.bio-techne.com\/resources\/literature\/brochure-cancer-metabolism-guide\">https:\/\/www.bio-techne.com\/resources\/literature\/brochure-cancer-metabol\u2026<\/a>","documentName":"Cancer 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