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Journal of Cancer Clinical Trials | Volume 2, Issue 4 | 2017

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dotted #CCC;' title='Kumar NM'>Kumar NM</a>, <a href='https://www.hilarispublisher.com/author-profile/sai-tnp-194420' style='color:#555; border-bottom:1px dotted #CCC;' title='Sai TNP'>Sai TNP</a>, <a href='https://www.hilarispublisher.com/author-profile/sai-psa-194421' style='color:#555; border-bottom:1px dotted #CCC;' title='Sai PSA'>Sai PSA</a>, <a href='https://www.hilarispublisher.com/author-profile/roy-a-194422' style='color:#555; border-bottom:1px dotted #CCC;' title='Roy A'>Roy A</a>, <a href='https://www.hilarispublisher.com/author-profile/paul-s-194423' style='color:#555; border-bottom:1px dotted #CCC;' title='Paul S'>Paul S</a> and <a href='https://www.hilarispublisher.com/author-profile/kumar-a-194424' style='color:#555; border-bottom:1px dotted #CCC;' title='Kumar A'>Kumar A</a> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract26370" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/lifetime-chance-of-getting-lung-cancer-a-review-26370.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/lifetime-chance-of-getting-lung-cancer-a-review.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2 a-share-icons ml-3"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/lifetime-chance-of-getting-lung-cancer-a-review.pdf" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/lifetime-chance-of-getting-lung-cancer-a-review.pdf" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/lifetime-chance-of-getting-lung-cancer-a-review.pdf" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/lifetime-chance-of-getting-lung-cancer-a-review.pdf" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/lifetime-chance-of-getting-lung-cancer-a-review.pdf" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract26370"> <div class="card card-body p-2 bg-light"><p>Lung cancer signifies to a critical issue for general wellbeing around the world. Lung carcinoma is a threatening lung tumour portrayed by uncontrolled cell development in fleshy tissue of the lung. This development can spread past the lung by the procedure of metastasis into close-by tissue or different parts of the body. Most malignancies that begin in the lung, known as essential lung diseases, are carcinomas. The two fundamental sorts are Small Cell Lung Carcinoma (SCLC) and Non-Small Cell Lung Carcinoma (NSCLC). The most widely recognized manifestations are blood slashing (counting hacking up blood), weight reduction, shortness of breath, and chest pains . Most of the Lung cancer cases are due to Tobacco or its other product involved nicotine</p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> Commentary </span> <span class="w-25 ml-4 text-right"> Pages: 1 - 3 </span> </div> <h3 class="mb-2 font-size-4"><a href="https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" title="Comparison of Health Utility Weights among Elderly Patients Receiving Hormonal Therapy With or Without Radiotherapy after Breast-Conserving Surgery: A Commentary">Comparison of Health Utility Weights among Elderly Patients Receiving Hormonal Therapy With or Without Radiotherapy after Breast-Conserving Surgery: A Commentary</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author-profile/askal-ayalew-alia-193099' style='color:#555; border-bottom:1px dotted #CCC;' title='Askal Ayalew Alia'>Askal Ayalew Alia</a> and <a href='https://www.hilarispublisher.com/author-profile/vakaramoko-diaby-193101' style='color:#555; border-bottom:1px dotted #CCC;' title='Vakaramoko Diaby'>Vakaramoko Diaby</a> </p> <div class="row justify-content-between align-items-center"> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2 a-share-icons ml-3"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/comparison-of-health-utility-weights-among-elderly-patients-receivinghormonal-therapy-with-or-without-radiotherapy-after-breastcon.pdf" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract26364"> <div class="card card-body p-2 bg-light"></div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> Commentary </span> <span class="w-25 ml-4 text-right"> Pages: 1 - 2 </span> </div> <h3 class="mb-2 font-size-4"><a href="https://www.hilarispublisher.com/open-access/deciphering-the-signalling-complexity-of-oncogenic-ras.pdf" title="Deciphering the Signalling Complexity of Oncogenic Ras">Deciphering the Signalling Complexity of Oncogenic Ras</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author-profile/tian-xu-192188' style='color:#555; 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border-bottom:1px dotted #CCC;' title='F Morano'>F Morano</a> and <a href='https://www.hilarispublisher.com/author-profile/m-di-bartolomeo-209484' style='color:#555; border-bottom:1px dotted #CCC;' title='M Di Bartolomeo'>M Di Bartolomeo</a> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract26362" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/osteopontin-expression-and-its-potential-role-as-prognostic-factor-and-therapeutic-target-for-gastric-cancer-26362.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/osteopontin-expression-and-its-potential-role-as-prognostic-factor-andtherapeutic-target.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2 a-share-icons ml-3"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/osteopontin-expression-and-its-potential-role-as-prognostic-factor-andtherapeutic-target.pdf" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/osteopontin-expression-and-its-potential-role-as-prognostic-factor-andtherapeutic-target.pdf" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/osteopontin-expression-and-its-potential-role-as-prognostic-factor-andtherapeutic-target.pdf" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/osteopontin-expression-and-its-potential-role-as-prognostic-factor-andtherapeutic-target.pdf" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/osteopontin-expression-and-its-potential-role-as-prognostic-factor-andtherapeutic-target.pdf" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract26362"> <div class="card card-body p-2 bg-light"><p>A correlation between the over expression of Osteopontin (OPN), E-cadherin, &beta;-catenin, and cyclooxygenase 2 and poor prognosis has been previously suggested in solid tumors. The aim of the ITACA-S translational study was to further investigate the correlation of these immunohistochemical biomarkers with the outcome of radically resected gastric cancer patient. The immunohistochemistry expression of osteopontin, E-cadherin, &beta;-catenin, and cyclooxygenase 2 was detected in 346 primary gastric tumor tissue samples from patients enrolled in the ITACA-S trial which randomized patients to receive adjuvant chemotherapy with ether 5-fluorouracil and leucovorin or a sequential regimen of infusional 5-fluorouracil and leucovorin plus irinotecan followed by cisplatin and docetaxel. A higher expression of OPN was associated to diffuse histotype, high grade and peritoneal relapse, but not with TNM stage. It was associated with higher risk of recurrence and metastases. Furthermore, OPN overexpression was identify as an independent prognostic factor for both relapse-free and overall survival. The abnormal expression of E-cadherin or b-catenin was correlated with more advanced disease stage and a poor outcome.</p> </div> </div> </div> </div> <div class="col-12 col-sm-3"> <!--==========Information topics==================--> <!--==========Information topics====END============--> <!--==========relevant topics==================--> <div class="mb-3"> <h4><a href="https://www.hilarispublisher.com/cancer-clinical-trials/awards-nomination.html" class="btn btn-danger btn-block mb-3 font-size-4">Awards & Nominations</a></h4> <h4><a href="https://www.hilarispublisher.com/cancer-clinical-trials-online-visitors-readers-118.html" class="btn btn-danger btn-block mb-3 font-size-4"><i class="fas fa-book-reader"></i> 50+ Million Readerbase</a></h4> <h4>Journal Highlights</h4> <nav class="nav flex-column scrollbar a-pl-0" style="max-height:50vh;"> <a href="https://www.hilarispublisher.com/scholarly/bladder-cancer-clinical-trials-journals-articles-ppts-list-653.html" class="nav-link" 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