Search results for: Sheau Yng Lim

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Lim</title> <meta name="description" content="Search results for: Sheau Yng Lim"> <meta name="keywords" content="Sheau Yng Lim"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Sheau Yng Lim"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Sheau Yng Lim</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Molecular Detection and Characterization of Infectious Bronchitis Virus from Libya</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdulwahab%20Kammon">Abdulwahab Kammon</a>, <a href="https://publications.waset.org/abstracts/search?q=Tan%20Sheau%20Wei"> Tan Sheau Wei</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Rahman%20Omar"> Abdul Rahman Omar</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdunaser%20Dayhum"> Abdunaser Dayhum</a>, <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20Eldghayes"> Ibrahim Eldghayes</a>, <a href="https://publications.waset.org/abstracts/search?q=Monier%20Sharif"> Monier Sharif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Infectious bronchitis virus (IBV) is a very dynamic and evolving virus which causing major economic losses to the global poultry industry. Recently, the Libyan poultry industry faced severe outbreak of respiratory distress associated with high mortality and dramatic drop in egg production. Tracheal and cloacal swabs were analyzed for several poultry viruses. IBV was detected using SYBR Green I real-time PCR detection based on the nucleocapsid (N) gene. Sequence analysis of the partial N gene indicated high similarity (~ 94%) to IBV strain 3382/06 that was isolated from Taiwan. Even though the IBV strain 3382/06 is more similar to that of the Mass type H120, the isolate has been implicated associated with intertypic recombinant of 3 putative parental IBV strains namely H120, Taiwan strain 1171/92 and China strain CK/CH/LDL/97I. Complete sequencing and antigenicity studies of the Libya IBV strains are currently underway to determine the evolution of the virus and its importance in vaccine induced immunity. In this paper, we documented for the first time the presence of possibly variant IBV strain from Libya which required a dramatic change in the vaccination program. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Libya" title="Libya">Libya</a>, <a href="https://publications.waset.org/abstracts/search?q=infectious%20bronchitis" title=" infectious bronchitis"> infectious bronchitis</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20characterization" title=" molecular characterization"> molecular characterization</a>, <a href="https://publications.waset.org/abstracts/search?q=viruses" title=" viruses"> viruses</a>, <a href="https://publications.waset.org/abstracts/search?q=vaccine" title=" vaccine "> vaccine </a> </p> <a href="https://publications.waset.org/abstracts/3241/molecular-detection-and-characterization-of-infectious-bronchitis-virus-from-libya" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3241.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">470</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Collagen Deposition in Lung Parenchyma Driven by Depletion of LYVE-1+ Macrophages Protects Emphysema and Loss of Airway Function</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yinebeb%20Mezgebu%20Dagnachew">Yinebeb Mezgebu Dagnachew</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwee%20Ying%20Lim"> Hwee Ying Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Liao%20Wupeng"> Liao Wupeng</a>, <a href="https://publications.waset.org/abstracts/search?q=Sheau%20Yng%20Lim"> Sheau Yng Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lim%20Sheng%20Jie%20Natalie"> Lim Sheng Jie Natalie</a>, <a href="https://publications.waset.org/abstracts/search?q=Veronique%20Angeli"> Veronique Angeli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Collagen is essential for maintaining lung structure and function, and its remodeling has been associated with respiratory diseases, including chronic obstructive pulmonary disease (COPD). However, the cellular mechanisms driving collagen remodeling and the functional implications of this process in the pathophysiology of pulmonary diseases remain poorly understood. Using a mouse model of Lyve-1 expressing macrophage depletion, we found that the absence of this subpopulation of tissue-resident macrophage led to the preferential deposition of type I collagen fibers around the alveoli and bronchi in the steady state. Further analysis by polarized light microscopy revealed that the collagen fibers accumulating in the lungs depleted of Lyve-1+ macrophages were thicker and crosslinked. A decrease in MMP-9 gene expression and proteolytic activity, together with an increase in Col1a1, Timp-3 and Lox gene expression, accompanied the collagen alterations. Next, we investigated the effect of the collagen remodeling on the pathophysiology of COPD and airway function in mouse lacking Lyve-1+ macrophage exposed chronically to cigarette smoke (CS), a well-established animal model of COPD. We showed that the deposition of collagen protected mouse against the destruction of alveoli (emphysema) and bronchi thickening after CS exposure and prevented loss of airway function. Thus, we demonstrate that interstitial Lyve-1+ macrophages regulate the composition, amount, and architecture of the collagen network in the lungs and that such collagen remodeling functionally impacts the development of COPD. This study further supports the potential of targeting collagen as a promising approach to treating respiratory diseases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lung" title="lung">lung</a>, <a href="https://publications.waset.org/abstracts/search?q=extracellular%20matrix" title=" extracellular matrix"> extracellular matrix</a>, <a href="https://publications.waset.org/abstracts/search?q=chronic%20obstructive%20pulmonary%20disease" title=" chronic obstructive pulmonary disease"> chronic obstructive pulmonary disease</a>, <a href="https://publications.waset.org/abstracts/search?q=matrix%20metalloproteinases" title=" matrix metalloproteinases"> matrix metalloproteinases</a>, <a href="https://publications.waset.org/abstracts/search?q=collagen" title=" collagen"> collagen</a> </p> <a href="https://publications.waset.org/abstracts/187346/collagen-deposition-in-lung-parenchyma-driven-by-depletion-of-lyve-1-macrophages-protects-emphysema-and-loss-of-airway-function" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">37</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th 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Search results for: Sheau Yng Lim