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These preclinical studies were conducted in well-characterized study models of Alzheimer’s disease.</p> <p><strong> </strong></p> <p>Recent preclinical studies further showed that INM-901 can be administered orally, with the same therapeutic effects in the brain as intraperitoneal injections. INM-901 oral formulation was shown to maintain similar drug exposure levels as intraperitoneal injections over a 24-hour period. Oral delivery offers multiple advantages, including an overall reduction in treatment delivery costs compared to intravenous delivery of large molecule antibody therapies currently administered in such cases.</p> <p><strong> </strong></p> <p>Large molecule antibody therapies are difficult to formulate orally and also present significant challenges to gastrointestinal tract absorption and further blood stream delivery, which is why IV or subcutaneous delivery methods need to be used instead. Additionally, large molecule therapies come with significant side effects, such as brain inflammation and bleeding, which requires constant monitoring and regular brain scans.</p> <p><strong> </strong></p> <p>InMed Pharmaceuticals is confident INM-901 oral formulation can address these issues by achieving better absorption in the GI tract and in the blood stream, effectively penetrating the blood-brain barrier, in addition to ease of administration and higher accessibility to patients.</p> <p><strong> </strong></p> <p>“We are excited by the recent data confirming that INM-901 can be delivered across the blood brain barrier to the brain tissue as an oral formulation which provides significant advantages for further development of this compound in the treatment of Alzheimer’s,” said Michael Woudenberg, InMed’s Chief Operating Officer and SVP of Chemistry, Manufacturing and Controls. “Similar drug levels in the target tissue are not usually seen between oral versus IP delivery. The supporting data generated by the oral formulation provides an attractive therapeutic approach given the many challenges associated with delivery of drug(s) to the brain.”</p> <p><strong> </strong></p> <p>The company is already conducting further research for the drug candidate substance and the product formulation, including dose ranging, drug metabolism and pharmacokinetic studies in view of submitting INM-901 for investigational new drug status with the Food and Drug Administration.</p> <p><strong> </strong></p> <p>The Alzheimer’s therapeutics market is projected to grow significantly in the coming years, driven by an aging global population and increasing prevalence of the disease. In 2022, the market was valued at $4.05 billion, and is expected to grow at a compound annual growth rate of 19.99% from 2023 to 2030, with a growing demand for effective therapies that can halt or slow the progression of the disease (<a href="https://cnw.fm/N4NkQ" target="_blank" rel="noreferrer noopener">https://cnw.fm/N4NkQ</a>).</p> <p><strong> </strong></p> <p>Given the current landscape, the positive preclinical results of INM-901 position InMed Pharmaceuticals as a potential leader in the development of promising, innovative treatments for Alzheimer’s. The formulation’s success could mark a significant advancement in Alzheimer’s care, offering hope to millions of patients worldwide.</p> <p><strong> </strong></p> <p>For more information, visit the company’s website at <a href="http://www.inmedpharma.com/" target="_blank" rel="noreferrer noopener">www.InMedPharma.com</a>.</p> <p><strong> </strong></p> <p><strong>NOTE TO INVESTORS:</strong> The latest news and updates relating to INM are available in the company’s newsroom at <a href="https://cnw.fm/INM" target="_blank" rel="noreferrer noopener">https://cnw.fm/INM</a></p> <p><strong>About HempWire</strong></p> <p><a href="https://www.hempwire.com/" target="_blank" rel="noopener">HempWire</a> (“HW”) is a specialized communications platform with a focus on hemp-related news, information, and the latest developments in the hemp sector. <a href="https://www.hempwire.com/" target="_blank" rel="noopener">HempWire</a> is one of 60+ brands within the <a href="https://www.investorbrandnetwork.com/dynamic-brand-portfolio/" target="_blank" rel="noopener"><strong>Dynamic Brand Portfolio</strong></a> @ <a href="https://www.investorbrandnetwork.com/" target="_blank" rel="noopener"><strong>IBN</strong></a> that delivers<strong>:</strong> (1) access to a vast network of wire solutions via <a href="https://www.investorwire.com/" target="_blank" rel="noopener">InvestorWire</a> to efficiently and effectively reach a myriad of target markets, demographics and diverse industries<strong>;</strong> (2) article and <a href="https://www.investorbrandnetwork.com/solutions/press-distribution-via-investorwire/syndication-partners/" target="_blank" rel="noopener">editorial syndication to 5,000+ outlets</a><strong>;</strong> (3) enhanced <a href="https://www.investorwire.com/investorwire-press-distribution/press-release-enhancement/" target="_blank" rel="noopener">press release enhancement</a> to ensure maximum impact<strong>;</strong> (4) <a href="https://www.investorbrandnetwork.com/social-media-network/" target="_blank" rel="noopener">social media distribution</a> via IBN to millions of social media followers<strong>;</strong> and (5) a full array of tailored <a href="https://www.investorbrandnetwork.com/solutions/" target="_blank" rel="noopener">corporate communications solutions</a>. 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