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(ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18583986" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fd5fbb56cad1c0f69b55ff975d4d0d68" rel="nofollow" data-download="{"attachment_id":40141702,"asset_id":18583986,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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surgery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">BACKGROUND: Clinical audit has been increasingly required for the accreditation process in every modern healthcare system. Data collection and analysis are excessively time-consuming in everyday practice. The primary aim of our study was... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73140595" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">BACKGROUND: Clinical audit has been increasingly required for the accreditation process in every modern healthcare system. Data collection and analysis are excessively time-consuming in everyday practice. 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Dioxide</a>, <script data-card-contents-for-ri="4594" type="text/json">{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="52438" href="https://www.academia.edu/Documents/in/Dogs">Dogs</a>, <script data-card-contents-for-ri="52438" type="text/json">{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a><script 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Gundry","profile_url":"https://independent.academia.edu/SGundry?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide?f_ri=424295","nofollow":false},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs?f_ri=424295","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=424295","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=424295","nofollow":false},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature?f_ri=424295"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=424295"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=424295"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen?f_ri=424295"},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium?f_ri=424295"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":618800,"name":"Coronary Circulation","url":"https://www.academia.edu/Documents/in/Coronary_Circulation?f_ri=424295"},{"id":1137254,"name":"Hydrogen-Ion Concentration","url":"https://www.academia.edu/Documents/in/Hydrogen-Ion_Concentration?f_ri=424295"},{"id":1185405,"name":"Myocardial Protection","url":"https://www.academia.edu/Documents/in/Myocardial_Protection?f_ri=424295"},{"id":1193624,"name":"Oxygen Consumption","url":"https://www.academia.edu/Documents/in/Oxygen_Consumption?f_ri=424295"},{"id":2207328,"name":"Heart Diseases","url":"https://www.academia.edu/Documents/in/Heart_Diseases?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_8313202" data-work_id="8313202" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/8313202/Gene_expression_profiles_predict_survival_of_patients_with_advanced_non_small_cell_lung_cancers">Gene expression profiles predict survival of patients with advanced non-small cell lung cancers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A large variation in prognosis is observed despite the use of clinical prognostic factors in patients with advanced non-small cell lung cancer (NSCLC). It is likely that this variation is due to the different biological properties of the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_8313202" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A large variation in prognosis is observed despite the use of clinical prognostic factors in patients with advanced non-small cell lung cancer (NSCLC). It is likely that this variation is due to the different biological properties of the tumour cells. In this work we aimed to identify gene signature that could predict survival in advanced NSCLC. Total RNA was extracted from five 5 μm-thick sections of the FFPE using the High Pure RNA Paraffin Kit (Roche). RNA amplification was performed using WT-Ovation™ FFPE RNA Amplification System V2 (NuGen). The amplified cDNA was then labelled and hybridised onto Illumina HumanRef-8 v3.0 Expression BeadChips. Microarray data analysis was subsequently performed using Genespring GX version 9.0. Out of 75 FFPE samples, only 32 had sufficient RNA quality and quantity for microarray gene expression analysis. Patients were grouped into long and short survival groups based on the time to cancer-related death. After normalization and filtration, 19,002 genes were selected for differential gene expression analysis. A total of 440 genes differed significantly between the long and short survival groups (ANOVA, p <; 0.05, with Benjamini and Hochberg False Discovery Rate multiple testing correction). Unsupervised Hierarchial Clustering with Pearson correlation and average linkage identified two broad clusters of patients corresponding to the long and short survival. Thirteen genes were selected based on the TTest, 2-fold expression changes, principal components analysis and univariate Cox regression analysis and risk scores were calculated for each patient. These gene signatures were independent predictors of survival. The model was validated with a published microarray data from 130 patients with NSCLC. Using Gene Set Analysis (GSA), we found certain biological processes including metastasis and chemotherapy resistance were up-regulated in the short survival group while TID pathway and MAPKKK cascade were enriched in th- - e long survival group. As the conclusion, there is several distinct gene expression profiles associated with survival of patients with advanced stage NSCLC. Survival outcomes in advanced NSCLC could be predicted based on a 13-gene signature.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/8313202" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8c578c2376d243c823410402bdc0bfc8" rel="nofollow" data-download="{"attachment_id":48142136,"asset_id":8313202,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48142136/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16571916" href="https://independent.academia.edu/FauziNur2">Fauzi Nur</a><script data-card-contents-for-user="16571916" type="text/json">{"id":16571916,"first_name":"Fauzi","last_name":"Nur","domain_name":"independent","page_name":"FauziNur2","display_name":"Fauzi Nur","profile_url":"https://independent.academia.edu/FauziNur2?f_ri=424295","photo":"https://0.academia-photos.com/16571916/5885877/6683965/s65_fauzi.nur.jpg_oh_aecf61d676e3fd542104126c21ea74be_oe_551c8605___gda___1424189880_573d2a82c63563d11b6c18fd16058beb"}</script></span></span></li><li class="js-paper-rank-work_8313202 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="8313202"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 8313202, container: ".js-paper-rank-work_8313202", }); 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$(".js-view-count[data-work-id=8313202]").text(description); $(".js-view-count-work_8313202").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_8313202").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="8313202"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">32</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3701" href="https://www.academia.edu/Documents/in/RNA">RNA</a>, <script data-card-contents-for-ri="3701" type="text/json">{"id":3701,"name":"RNA","url":"https://www.academia.edu/Documents/in/RNA?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5069" href="https://www.academia.edu/Documents/in/Principal_Component_Analysis">Principal Component Analysis</a>, <script data-card-contents-for-ri="5069" type="text/json">{"id":5069,"name":"Principal Component Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a><script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=8313202]'), work: {"id":8313202,"title":"Gene expression profiles predict survival of patients with advanced non-small cell lung cancers","created_at":"2014-09-13T13:03:18.434-07:00","url":"https://www.academia.edu/8313202/Gene_expression_profiles_predict_survival_of_patients_with_advanced_non_small_cell_lung_cancers?f_ri=424295","dom_id":"work_8313202","summary":"A large variation in prognosis is observed despite the use of clinical prognostic factors in patients with advanced non-small cell lung cancer (NSCLC). It is likely that this variation is due to the different biological properties of the tumour cells. In this work we aimed to identify gene signature that could predict survival in advanced NSCLC. Total RNA was extracted from five 5 μm-thick sections of the FFPE using the High Pure RNA Paraffin Kit (Roche). RNA amplification was performed using WT-Ovation™ FFPE RNA Amplification System V2 (NuGen). The amplified cDNA was then labelled and hybridised onto Illumina HumanRef-8 v3.0 Expression BeadChips. Microarray data analysis was subsequently performed using Genespring GX version 9.0. Out of 75 FFPE samples, only 32 had sufficient RNA quality and quantity for microarray gene expression analysis. Patients were grouped into long and short survival groups based on the time to cancer-related death. After normalization and filtration, 19,002 genes were selected for differential gene expression analysis. A total of 440 genes differed significantly between the long and short survival groups (ANOVA, p \u003c; 0.05, with Benjamini and Hochberg False Discovery Rate multiple testing correction). Unsupervised Hierarchial Clustering with Pearson correlation and average linkage identified two broad clusters of patients corresponding to the long and short survival. Thirteen genes were selected based on the TTest, 2-fold expression changes, principal components analysis and univariate Cox regression analysis and risk scores were calculated for each patient. These gene signatures were independent predictors of survival. The model was validated with a published microarray data from 130 patients with NSCLC. Using Gene Set Analysis (GSA), we found certain biological processes including metastasis and chemotherapy resistance were up-regulated in the short survival group while TID pathway and MAPKKK cascade were enriched in th- - e long survival group. As the conclusion, there is several distinct gene expression profiles associated with survival of patients with advanced stage NSCLC. Survival outcomes in advanced NSCLC could be predicted based on a 13-gene signature.","downloadable_attachments":[{"id":48142136,"asset_id":8313202,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":16571916,"first_name":"Fauzi","last_name":"Nur","domain_name":"independent","page_name":"FauziNur2","display_name":"Fauzi Nur","profile_url":"https://independent.academia.edu/FauziNur2?f_ri=424295","photo":"https://0.academia-photos.com/16571916/5885877/6683965/s65_fauzi.nur.jpg_oh_aecf61d676e3fd542104126c21ea74be_oe_551c8605___gda___1424189880_573d2a82c63563d11b6c18fd16058beb"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=424295","nofollow":false},{"id":3701,"name":"RNA","url":"https://www.academia.edu/Documents/in/RNA?f_ri=424295","nofollow":false},{"id":5069,"name":"Principal Component 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Regression","url":"https://www.academia.edu/Documents/in/Cox_Regression?f_ri=424295"},{"id":82988,"name":"Microarray","url":"https://www.academia.edu/Documents/in/Microarray?f_ri=424295"},{"id":174778,"name":"Principal Components Analysis","url":"https://www.academia.edu/Documents/in/Principal_Components_Analysis?f_ri=424295"},{"id":187402,"name":"Cross Validation","url":"https://www.academia.edu/Documents/in/Cross_Validation?f_ri=424295"},{"id":371716,"name":"Pearson Correlation","url":"https://www.academia.edu/Documents/in/Pearson_Correlation?f_ri=424295"},{"id":375301,"name":"Microarray Analysis","url":"https://www.academia.edu/Documents/in/Microarray_Analysis?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=424295"},{"id":495625,"name":"Biological Process","url":"https://www.academia.edu/Documents/in/Biological_Process?f_ri=424295"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=424295"},{"id":600278,"name":"False discovery rate","url":"https://www.academia.edu/Documents/in/False_discovery_rate?f_ri=424295"},{"id":749302,"name":"Indexation","url":"https://www.academia.edu/Documents/in/Indexation?f_ri=424295"},{"id":823464,"name":"Gene Expression Analysis","url":"https://www.academia.edu/Documents/in/Gene_Expression_Analysis?f_ri=424295"},{"id":860345,"name":"Low Risk","url":"https://www.academia.edu/Documents/in/Low_Risk?f_ri=424295"},{"id":995219,"name":"ADJUVANT THERAPY","url":"https://www.academia.edu/Documents/in/ADJUVANT_THERAPY?f_ri=424295"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=424295"},{"id":1548118,"name":"Non small Cell Lung Cancer","url":"https://www.academia.edu/Documents/in/Non_small_Cell_Lung_Cancer?f_ri=424295"},{"id":1578784,"name":"Differential Gene Expression","url":"https://www.academia.edu/Documents/in/Differential_Gene_Expression?f_ri=424295"},{"id":1745478,"name":"Adenocarcinoma","url":"https://www.academia.edu/Documents/in/Adenocarcinoma?f_ri=424295"},{"id":1750690,"name":"Microarray Data","url":"https://www.academia.edu/Documents/in/Microarray_Data?f_ri=424295"},{"id":1810445,"name":"Gene expression profiling","url":"https://www.academia.edu/Documents/in/Gene_expression_profiling?f_ri=424295"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=424295"},{"id":1937356,"name":"Risk Score","url":"https://www.academia.edu/Documents/in/Risk_Score?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10077402" data-work_id="10077402" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10077402/Potent_anti_retroviral_therapy_with_or_without_cidofovir_for_AIDS_associated_progressive_multifocal_leukoencephalopathy_Extended_follow_up_of_an_observational_study">Potent anti-retroviral therapy with or without cidofovir for AIDS-associated progressive multifocal leukoencephalopathy: Extended follow-up of an observational study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To analyze the clinical efficacy of cidofovir combined with highly active anti-retroviral therapy (HAART) in AIDS-related progressive multifocal leukoen-cepalopathy (PML), a multicenter observational study was performed. Consecutive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10077402" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To analyze the clinical efficacy of cidofovir combined with highly active anti-retroviral therapy (HAART) in AIDS-related progressive multifocal leukoen-cepalopathy (PML), a multicenter observational study was performed. Consecutive HIV-positive patients with histologically or virologically proven PML and at least 4 weeks of treatment after diagnosis were examined: 27 patients were treated with HAART, whereas 16 patients were treated with HAART plus cidofovir 5 mg/kg intravenously per week for the first 2 weeks and every other week thereafter. JC virus DNA was quantified in cerebrospinal fluid (CSF) by PCR. Baseline virologic, immunologic, and clinical characteristics as well as HIV RNA and CD4 responses to HAART were homogeneous between the groups. The median follow-up was 132 weeks. In one case (6%), cidofovir was permanently discontinued because of severe proteinuria. One-year cumulative probability of survival was 0.61 with cidofovir and 0.29 without (log rank test P = 0.02). After adjusting for baseline CD4 counts, JC viral load in CSF, Karnofsky, and use of HAART prior to the onset of PML, the use of cidofovir was independently associated with a reduced risk of death (hazard ratio, 0.21, 95% confidence interval, 0.07–0.65; P = 0.005). A randomized study will definitively establish whether cidofovir confers significant advantage over HAART alone in AIDS-related PML.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10077402" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6a7adf71f85f68bf9d1a5bcb87f8fcaa" rel="nofollow" data-download="{"attachment_id":47543746,"asset_id":10077402,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47543746/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24544672" href="https://independent.academia.edu/AndreaDeLuca2">Andrea De Luca</a><script data-card-contents-for-user="24544672" type="text/json">{"id":24544672,"first_name":"Andrea","last_name":"De Luca","domain_name":"independent","page_name":"AndreaDeLuca2","display_name":"Andrea De Luca","profile_url":"https://independent.academia.edu/AndreaDeLuca2?f_ri=424295","photo":"https://0.academia-photos.com/24544672/6629390/7492776/s65_andrea.de_luca.jpg_oh_67962ce10826644516da4d47c38e74a5_oe_553e384e___gda___1430274461_ccb54733adeaf4b6b77c176932315e76"}</script></span></span></li><li class="js-paper-rank-work_10077402 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10077402"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10077402, container: ".js-paper-rank-work_10077402", }); 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Consecutive HIV-positive patients with histologically or virologically proven PML and at least 4 weeks of treatment after diagnosis were examined: 27 patients were treated with HAART, whereas 16 patients were treated with HAART plus cidofovir 5 mg/kg intravenously per week for the first 2 weeks and every other week thereafter. JC virus DNA was quantified in cerebrospinal fluid (CSF) by PCR. Baseline virologic, immunologic, and clinical characteristics as well as HIV RNA and CD4 responses to HAART were homogeneous between the groups. The median follow-up was 132 weeks. In one case (6%), cidofovir was permanently discontinued because of severe proteinuria. One-year cumulative probability of survival was 0.61 with cidofovir and 0.29 without (log rank test P = 0.02). After adjusting for baseline CD4 counts, JC viral load in CSF, Karnofsky, and use of HAART prior to the onset of PML, the use of cidofovir was independently associated with a reduced risk of death (hazard ratio, 0.21, 95% confidence interval, 0.07–0.65; P = 0.005). A randomized study will definitively establish whether cidofovir confers significant advantage over HAART alone in AIDS-related PML.","downloadable_attachments":[{"id":47543746,"asset_id":10077402,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24544672,"first_name":"Andrea","last_name":"De Luca","domain_name":"independent","page_name":"AndreaDeLuca2","display_name":"Andrea De Luca","profile_url":"https://independent.academia.edu/AndreaDeLuca2?f_ri=424295","photo":"https://0.academia-photos.com/24544672/6629390/7492776/s65_andrea.de_luca.jpg_oh_67962ce10826644516da4d47c38e74a5_oe_553e384e___gda___1430274461_ccb54733adeaf4b6b77c176932315e76"}],"research_interests":[{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=424295","nofollow":false},{"id":60971,"name":"Cerebrospinal 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data-has-card-for-ri="7361" href="https://www.academia.edu/Documents/in/Pakistan">Pakistan</a>, <script data-card-contents-for-ri="7361" type="text/json">{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="28235" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a>, <script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37292" href="https://www.academia.edu/Documents/in/Colorectal_cancer">Colorectal cancer</a>, <script data-card-contents-for-ri="37292" type="text/json">{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer?f_ri=424295","nofollow":false}</script><a 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The purpose of this investigation was to assess the adjuvant... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23399347" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Electrochemotherapy (ECT) is a novel anticancer therapy that combines the delivery of trains of appropriate waveforms with the local administration of chemotherapy agents. The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT). Twenty-eight privately-owned dogs with incompletely removed MCT were treated with intralesional bleomycin (1.5 IU/cm2) followed by the application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50 + 50 micros duration, 1 Hz frequency). The overall response rate was 85% with a mean estimated time to recurrence of 52.76 +/- 6.5 months (range: 39.99 to 65.54 months, 95% CI). At the time of writing this report, the median survival time was not reached. Three dogs died of metastatic disease that they developed at the same time of local recurrence, one developed multiple cutaneous nodules at different locations and one with recurrence was re-treated and is currently disease...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23399347" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a1e019cfe4bc277fd0ccc0870a9fc7a9" rel="nofollow" data-download="{"attachment_id":43847062,"asset_id":23399347,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43847062/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33983376" href="https://unina2.academia.edu/AlfonsoBaldi">Alfonso Baldi</a><script data-card-contents-for-user="33983376" type="text/json">{"id":33983376,"first_name":"Alfonso","last_name":"Baldi","domain_name":"unina2","page_name":"AlfonsoBaldi","display_name":"Alfonso Baldi","profile_url":"https://unina2.academia.edu/AlfonsoBaldi?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_23399347 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23399347"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23399347, container: ".js-paper-rank-work_23399347", }); 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The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT). Twenty-eight privately-owned dogs with incompletely removed MCT were treated with intralesional bleomycin (1.5 IU/cm2) followed by the application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50 + 50 micros duration, 1 Hz frequency). The overall response rate was 85% with a mean estimated time to recurrence of 52.76 +/- 6.5 months (range: 39.99 to 65.54 months, 95% CI). At the time of writing this report, the median survival time was not reached. Three dogs died of metastatic disease that they developed at the same time of local recurrence, one developed multiple cutaneous nodules at different locations and one with recurrence was re-treated and is currently disease...","downloadable_attachments":[{"id":43847062,"asset_id":23399347,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33983376,"first_name":"Alfonso","last_name":"Baldi","domain_name":"unina2","page_name":"AlfonsoBaldi","display_name":"Alfonso Baldi","profile_url":"https://unina2.academia.edu/AlfonsoBaldi?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment 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Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22944800" data-work_id="22944800" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22944800/Simulating_smallmouth_bass_reproductive_success_in_reservoirs">Simulating smallmouth bass reproductive success in reservoirs</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22944800" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i 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itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44643569" href="https://independent.academia.edu/JamesChandler5">James Chandler</a><script data-card-contents-for-user="44643569" type="text/json">{"id":44643569,"first_name":"James","last_name":"Chandler","domain_name":"independent","page_name":"JamesChandler5","display_name":"James Chandler","profile_url":"https://independent.academia.edu/JamesChandler5?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22944800 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22944800"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22944800, container: ".js-paper-rank-work_22944800", }); });</script></li><li class="js-percentile-work_22944800 InlineList-item InlineList-item--bordered 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Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="129739" href="https://www.academia.edu/Documents/in/Anesthesia">Anesthesia</a>, <script data-card-contents-for-ri="129739" type="text/json">{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="182430" href="https://www.academia.edu/Documents/in/Arterial_Blood_Pressure">Arterial Blood Pressure</a><script data-card-contents-for-ri="182430" type="text/json">{"id":182430,"name":"Arterial Blood Pressure","url":"https://www.academia.edu/Documents/in/Arterial_Blood_Pressure?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19485274]'), work: {"id":19485274,"title":"Pulse Pressure and Long-Term Survival 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u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="49633" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="96213" href="https://www.academia.edu/Documents/in/Hospitalization">Hospitalization</a>, <script data-card-contents-for-ri="96213" type="text/json">{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="133057" href="https://www.academia.edu/Documents/in/Young_Adult">Young Adult</a>, <script data-card-contents-for-ri="133057" type="text/json">{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a><script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48727123]'), work: {"id":48727123,"title":"Heart Failure in Young Adults Is Associated With High Mortality: A Contemporary Population-Level 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haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16486719" data-work_id="16486719" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16486719/Vertebral_Artery_Reconstruction">Vertebral Artery Reconstruction</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16486719" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span 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class="u-tcGrayDark u-fw700" data-has-card-for-user="35699416" href="https://independent.academia.edu/RBerguer">Ramon Berguer</a><script data-card-contents-for-user="35699416" type="text/json">{"id":35699416,"first_name":"Ramon","last_name":"Berguer","domain_name":"independent","page_name":"RBerguer","display_name":"Ramon Berguer","profile_url":"https://independent.academia.edu/RBerguer?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16486719 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16486719"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16486719, container: ".js-paper-rank-work_16486719", }); });</script></li><li class="js-percentile-work_16486719 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget 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href="https://www.academia.edu/Documents/in/Cerebrovascular_Disease">Cerebrovascular Disease</a>, <script data-card-contents-for-ri="91905" type="text/json">{"id":91905,"name":"Cerebrovascular Disease","url":"https://www.academia.edu/Documents/in/Cerebrovascular_Disease?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="203765" href="https://www.academia.edu/Documents/in/Diagnostic_Imaging">Diagnostic Imaging</a><script data-card-contents-for-ri="203765" type="text/json">{"id":203765,"name":"Diagnostic Imaging","url":"https://www.academia.edu/Documents/in/Diagnostic_Imaging?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16486719]'), work: {"id":16486719,"title":"Vertebral Artery Reconstruction","created_at":"2015-10-05T11:55:06.995-07:00","url":"https://www.academia.edu/16486719/Vertebral_Artery_Reconstruction?f_ri=424295","dom_id":"work_16486719","summary":null,"downloadable_attachments":[{"id":42480590,"asset_id":16486719,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35699416,"first_name":"Ramon","last_name":"Berguer","domain_name":"independent","page_name":"RBerguer","display_name":"Ramon Berguer","profile_url":"https://independent.academia.edu/RBerguer?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":25398,"name":"Vascular 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href="https://www.academia.edu/73820357/Treatment_of_childhood_T_cell_lymphoblastic_lymphoma_according_to_the_strategy_for_acute_lymphoblastic_leukaemia_without_radiotherapy_Long_term_results_of_the_EORTC_CLG_58881_trial">Treatment of childhood T-cell lymphoblastic lymphoma according to the strategy for acute lymphoblastic leukaemia, without radiotherapy: Long term results of the EORTC CLG 58881 trial</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73820357" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7a21f105711de8802ccbcefd2c91f770" rel="nofollow" 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type="text/json">{"id":33277154,"first_name":"Marleen","last_name":"Renard","domain_name":"independent","page_name":"MarleenRenard","display_name":"Marleen Renard","profile_url":"https://independent.academia.edu/MarleenRenard?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73820357 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73820357"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73820357, container: ".js-paper-rank-work_73820357", }); });</script></li><li class="js-percentile-work_73820357 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73820357; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73820357"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73820357 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73820357"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73820357; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73820357]").text(description); $(".js-view-count-work_73820357").attr('title', description).tooltip(); }); });</script></span><script>$(function() { 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Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73820357]'), work: {"id":73820357,"title":"Treatment of childhood T-cell lymphoblastic lymphoma according to the strategy for acute lymphoblastic leukaemia, 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Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":546940,"name":"Standard Error","url":"https://www.academia.edu/Documents/in/Standard_Error?f_ri=424295"},{"id":1225372,"name":"Overall Survival","url":"https://www.academia.edu/Documents/in/Overall_Survival?f_ri=424295"},{"id":2180163,"name":"Prophylactic Cranial Irradiation","url":"https://www.academia.edu/Documents/in/Prophylactic_Cranial_Irradiation?f_ri=424295"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=424295"},{"id":3082379,"name":"Disease Free Survival","url":"https://www.academia.edu/Documents/in/Disease_Free_Survival?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70186768" data-work_id="70186768" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70186768/Psychiatric_Disorders_and_Survival_After_Lung_Transplantation">Psychiatric Disorders and Survival After Lung Transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The 30 patients who underwent lung transplantation between 1990 and 1996 were included in this study, and data were analyzed to find predictors of 1-year survival posttransplantation. All patients were followed throughout the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70186768" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The 30 patients who underwent lung transplantation between 1990 and 1996 were included in this study, and data were analyzed to find predictors of 1-year survival posttransplantation. All patients were followed throughout the posttransplantation period. Fifteen patients had ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70186768" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="48d06a70cd39f9175b0a8ebfbac0eb6b" rel="nofollow" data-download="{"attachment_id":80033383,"asset_id":70186768,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80033383/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55867188" href="https://independent.academia.edu/CatherineWoodman">Catherine Woodman</a><script data-card-contents-for-user="55867188" type="text/json">{"id":55867188,"first_name":"Catherine","last_name":"Woodman","domain_name":"independent","page_name":"CatherineWoodman","display_name":"Catherine Woodman","profile_url":"https://independent.academia.edu/CatherineWoodman?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70186768 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70186768"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70186768, container: ".js-paper-rank-work_70186768", }); });</script></li><li class="js-percentile-work_70186768 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70186768; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_70186768"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_70186768 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="70186768"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70186768; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70186768]").text(description); $(".js-view-count-work_70186768").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70186768").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70186768"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1314" href="https://www.academia.edu/Documents/in/Anxiety_Disorders">Anxiety Disorders</a>, <script data-card-contents-for-ri="1314" type="text/json">{"id":1314,"name":"Anxiety Disorders","url":"https://www.academia.edu/Documents/in/Anxiety_Disorders?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8207" href="https://www.academia.edu/Documents/in/Risk">Risk</a>, <script data-card-contents-for-ri="8207" type="text/json">{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70186768]'), work: {"id":70186768,"title":"Psychiatric Disorders and Survival After Lung Transplantation","created_at":"2022-01-31T17:16:00.250-08:00","url":"https://www.academia.edu/70186768/Psychiatric_Disorders_and_Survival_After_Lung_Transplantation?f_ri=424295","dom_id":"work_70186768","summary":"The 30 patients who underwent lung transplantation between 1990 and 1996 were included in this study, and data were analyzed to find predictors of 1-year survival posttransplantation. All patients were followed throughout the posttransplantation period. Fifteen patients had ...","downloadable_attachments":[{"id":80033383,"asset_id":70186768,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":55867188,"first_name":"Catherine","last_name":"Woodman","domain_name":"independent","page_name":"CatherineWoodman","display_name":"Catherine Woodman","profile_url":"https://independent.academia.edu/CatherineWoodman?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=424295","nofollow":false},{"id":1314,"name":"Anxiety Disorders","url":"https://www.academia.edu/Documents/in/Anxiety_Disorders?f_ri=424295","nofollow":false},{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=424295","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=424295","nofollow":false},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=424295"},{"id":101594,"name":"Psychosomatics","url":"https://www.academia.edu/Documents/in/Psychosomatics?f_ri=424295"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=424295"},{"id":157943,"name":"Depressive Disorder","url":"https://www.academia.edu/Documents/in/Depressive_Disorder?f_ri=424295"},{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders?f_ri=424295"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":429252,"name":"Somatoform disorders","url":"https://www.academia.edu/Documents/in/Somatoform_disorders?f_ri=424295"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications?f_ri=424295"},{"id":2731176,"name":"Lung Transplantation","url":"https://www.academia.edu/Documents/in/Lung_Transplantation?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63401242" data-work_id="63401242" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63401242/Survival_of_women_with_locally_advanced_breast_cancer_at_a_teaching_hospital_in_Lahore">Survival of women with locally advanced breast cancer at a teaching hospital in Lahore</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63401242" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively over 9 years with Stage III breast cancer were evaluated for age, socio-economic status (SES), tumour size and grade, number of involved lymph nodes, stage III sub-categories, estrogen and progesterone receptor (ER/PR) status, treatment profiles and responses, and sites of relapse. EFS and OS at 5 and 10 years were calculated. Median age was 45 years. Poorly differentiated tumours were found in 127 patients, while 128 had larger tumours (T3 and T4). Eighty women had extensive nodal involvement (N2 and N3), and 86 had Stage IIIA tumours. Chemotherapy was given to 44 patients before surgery and one of these patients achieved pathological complete response. At 5 and 10 years, EFS was 25% and 7%, and OS was 52% and 31%, respectively. By Cox regression a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63401242" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="df086514ae3ea09400e968668329c0bf" rel="nofollow" data-download="{"attachment_id":75843954,"asset_id":63401242,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75843954/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34372370" href="https://independent.academia.edu/DrMAsifSaeed">Dr. M. Asif Saeed</a><script data-card-contents-for-user="34372370" type="text/json">{"id":34372370,"first_name":"Dr. M. Asif","last_name":"Saeed","domain_name":"independent","page_name":"DrMAsifSaeed","display_name":"Dr. M. Asif Saeed","profile_url":"https://independent.academia.edu/DrMAsifSaeed?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_63401242 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63401242"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63401242, container: ".js-paper-rank-work_63401242", }); });</script></li><li class="js-percentile-work_63401242 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63401242; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_63401242"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_63401242 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="63401242"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63401242; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63401242]").text(description); $(".js-view-count-work_63401242").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63401242").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63401242"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6802" href="https://www.academia.edu/Documents/in/Breast_Cancer">Breast Cancer</a>, <script data-card-contents-for-ri="6802" type="text/json">{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7361" href="https://www.academia.edu/Documents/in/Pakistan">Pakistan</a>, <script data-card-contents-for-ri="7361" type="text/json">{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a><script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63401242]'), work: {"id":63401242,"title":"Survival of women with locally advanced breast cancer at a teaching hospital in Lahore","created_at":"2021-12-06T22:09:29.531-08:00","url":"https://www.academia.edu/63401242/Survival_of_women_with_locally_advanced_breast_cancer_at_a_teaching_hospital_in_Lahore?f_ri=424295","dom_id":"work_63401242","summary":"To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively over 9 years with Stage III breast cancer were evaluated for age, socio-economic status (SES), tumour size and grade, number of involved lymph nodes, stage III sub-categories, estrogen and progesterone receptor (ER/PR) status, treatment profiles and responses, and sites of relapse. EFS and OS at 5 and 10 years were calculated. Median age was 45 years. Poorly differentiated tumours were found in 127 patients, while 128 had larger tumours (T3 and T4). Eighty women had extensive nodal involvement (N2 and N3), and 86 had Stage IIIA tumours. Chemotherapy was given to 44 patients before surgery and one of these patients achieved pathological complete response. At 5 and 10 years, EFS was 25% and 7%, and OS was 52% and 31%, respectively. By Cox regression a...","downloadable_attachments":[{"id":75843954,"asset_id":63401242,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34372370,"first_name":"Dr. M. Asif","last_name":"Saeed","domain_name":"independent","page_name":"DrMAsifSaeed","display_name":"Dr. M. Asif Saeed","profile_url":"https://independent.academia.edu/DrMAsifSaeed?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=424295","nofollow":false},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=424295","nofollow":false},{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=424295","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=424295","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=424295"},{"id":70854,"name":"Developing Country","url":"https://www.academia.edu/Documents/in/Developing_Country?f_ri=424295"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=424295"},{"id":158839,"name":"Breast Cancer Research","url":"https://www.academia.edu/Documents/in/Breast_Cancer_Research?f_ri=424295"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=424295"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=424295"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy?f_ri=424295"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=424295"},{"id":3082379,"name":"Disease Free Survival","url":"https://www.academia.edu/Documents/in/Disease_Free_Survival?f_ri=424295"},{"id":3118074,"name":"Neoplasm staging","url":"https://www.academia.edu/Documents/in/Neoplasm_staging?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_59915150" data-work_id="59915150" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59915150/Radiation_with_or_without_Antiandrogen_Therapy_in_Recurrent_Prostate_Cancer">Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background Salvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_59915150" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background Salvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) level. Whether antiandrogen therapy with radiation therapy will further improve cancer control and prolong overall survival is unknown. Methods In a double-blind, placebo-controlled trial conducted from 1998 through 2003, we assigned 760 eligible patients who had undergone prostatectomy with a lymphadenectomy and had disease, as assessed on pathological testing, with a tumor stage of T2 (confined to the prostate but with a positive surgical margin) or T3 (with histologic extension beyond the prostatic capsule), no nodal involvement, and a detectable PSA level of 0.2 to 4.0 ng per milliliter to undergo radiation therapy and receive either antiandrogen therapy (24 months of bicalutamide at a dose of 150 mg daily) or daily placebo tablets during and after...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59915150" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a4d4b8bce5d3ee489844e30088e7115e" rel="nofollow" data-download="{"attachment_id":73595856,"asset_id":59915150,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73595856/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42486127" href="https://independent.academia.edu/LSouhami">Luis Souhami</a><script data-card-contents-for-user="42486127" type="text/json">{"id":42486127,"first_name":"Luis","last_name":"Souhami","domain_name":"independent","page_name":"LSouhami","display_name":"Luis Souhami","profile_url":"https://independent.academia.edu/LSouhami?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_59915150 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="59915150"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 59915150, container: ".js-paper-rank-work_59915150", }); 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$(".js-view-count[data-work-id=59915150]").text(description); $(".js-view-count-work_59915150").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_59915150").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="59915150"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="19354" href="https://www.academia.edu/Documents/in/Radiotherapy">Radiotherapy</a>, <script data-card-contents-for-ri="19354" type="text/json">{"id":19354,"name":"Radiotherapy","url":"https://www.academia.edu/Documents/in/Radiotherapy?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="83906" href="https://www.academia.edu/Documents/in/Nitriles">Nitriles</a>, <script data-card-contents-for-ri="83906" type="text/json">{"id":83906,"name":"Nitriles","url":"https://www.academia.edu/Documents/in/Nitriles?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a><script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=59915150]'), work: {"id":59915150,"title":"Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer","created_at":"2021-10-25T06:50:36.055-07:00","url":"https://www.academia.edu/59915150/Radiation_with_or_without_Antiandrogen_Therapy_in_Recurrent_Prostate_Cancer?f_ri=424295","dom_id":"work_59915150","summary":"Background Salvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) level. Whether antiandrogen therapy with radiation therapy will further improve cancer control and prolong overall survival is unknown. Methods In a double-blind, placebo-controlled trial conducted from 1998 through 2003, we assigned 760 eligible patients who had undergone prostatectomy with a lymphadenectomy and had disease, as assessed on pathological testing, with a tumor stage of T2 (confined to the prostate but with a positive surgical margin) or T3 (with histologic extension beyond the prostatic capsule), no nodal involvement, and a detectable PSA level of 0.2 to 4.0 ng per milliliter to undergo radiation therapy and receive either antiandrogen therapy (24 months of bicalutamide at a dose of 150 mg daily) or daily placebo tablets during and after...","downloadable_attachments":[{"id":73595856,"asset_id":59915150,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42486127,"first_name":"Luis","last_name":"Souhami","domain_name":"independent","page_name":"LSouhami","display_name":"Luis Souhami","profile_url":"https://independent.academia.edu/LSouhami?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":19354,"name":"Radiotherapy","url":"https://www.academia.edu/Documents/in/Radiotherapy?f_ri=424295","nofollow":false},{"id":83906,"name":"Nitriles","url":"https://www.academia.edu/Documents/in/Nitriles?f_ri=424295","nofollow":false},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=424295","nofollow":false},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=424295","nofollow":false},{"id":208575,"name":"Gynecomastia","url":"https://www.academia.edu/Documents/in/Gynecomastia?f_ri=424295"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":1161066,"name":"New England Journalof Medicine","url":"https://www.academia.edu/Documents/in/New_England_Journalof_Medicine?f_ri=424295"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy?f_ri=424295"},{"id":3118074,"name":"Neoplasm staging","url":"https://www.academia.edu/Documents/in/Neoplasm_staging?f_ri=424295"},{"id":3205111,"name":"Prostatic neoplasms","url":"https://www.academia.edu/Documents/in/Prostatic_neoplasms?f_ri=424295"},{"id":3382526,"name":"Prostatectomy","url":"https://www.academia.edu/Documents/in/Prostatectomy?f_ri=424295"},{"id":3602969,"name":"Neoplasm metastasis","url":"https://www.academia.edu/Documents/in/Neoplasm_metastasis?f_ri=424295"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_56040001" data-work_id="56040001" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/56040001/Combination_chemotherapy_without_cisplatin_in_the_treatment_of_advanced_non_small_cell_lung_cancer">Combination chemotherapy without cisplatin in the treatment of advanced non-small cell lung cancer</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/56040001" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e42f459777fad499f04617316cd5ed3b" rel="nofollow" data-download="{"attachment_id":71621698,"asset_id":56040001,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71621698/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33123535" href="https://irsp-ouidah.academia.edu/XQuantin">X. 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js-work-card work_50680148" data-work_id="50680148" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/50680148/Early_stage_carcinoma_of_oral_tongue_prognostic_factors_for_local_control_and_survival">Early stage carcinoma of oral tongue: prognostic factors for local control and survival</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50680148" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a 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href="https://www.academia.edu/49965050/The_Pawpaw_Regional_Variety_Trial_Background_and_Early_Data">The Pawpaw Regional Variety Trial: Background and Early Data</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Beginning in 1993, 12 institutions and individuals and The PawPaw Foundation (PPF) embarked on a joint venture to evaluate commercially-available, named pawpaw (Asimina triloba) varieties and PPF&#39;s advanced selections within and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49965050" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Beginning in 1993, 12 institutions and individuals and The PawPaw Foundation (PPF) embarked on a joint venture to evaluate commercially-available, named pawpaw (Asimina triloba) varieties and PPF&#39;s advanced selections within and outside of the pawpaw&#39;s native range. Each Pawpaw Regional Variety Trial (PRVT) planting, consists of about 300 trees, with five to eight replications (blocks) of 28 grafted scion varieties per block in a randomized complete block design (10 named varieties and 18 clones selected in the PPF orchards at the University of Maryland Experiment Stations at Queenstown and Keedysville, Md.). Variables being examined in the trial include climatic effect, culture, pests, growth, fl owering, yield, and fruit characteristics. In 1995, PRVT plantings were established in Kentucky (Princeton, Ky.), Louisiana, North Carolina, Oregon, and South Carolina. In 1998, a second planting was established in Kentucky (Frankfort, Ky.). In 1999, PRVT plantings were established...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49965050" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1d05761b099b0f566cd8296d9d2e9a35" rel="nofollow" data-download="{"attachment_id":68125549,"asset_id":49965050,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68125549/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="62227795" href="https://auburn.academia.edu/DesmondLayne">Desmond Layne</a><script data-card-contents-for-user="62227795" type="text/json">{"id":62227795,"first_name":"Desmond","last_name":"Layne","domain_name":"auburn","page_name":"DesmondLayne","display_name":"Desmond Layne","profile_url":"https://auburn.academia.edu/DesmondLayne?f_ri=424295","photo":"https://0.academia-photos.com/62227795/16147999/16592290/s65_desmond.layne.jpg"}</script></span></span></li><li class="js-paper-rank-work_49965050 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49965050"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49965050, container: ".js-paper-rank-work_49965050", }); 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Each Pawpaw Regional Variety Trial (PRVT) planting, consists of about 300 trees, with five to eight replications (blocks) of 28 grafted scion varieties per block in a randomized complete block design (10 named varieties and 18 clones selected in the PPF orchards at the University of Maryland Experiment Stations at Queenstown and Keedysville, Md.). Variables being examined in the trial include climatic effect, culture, pests, growth, fl owering, yield, and fruit characteristics. In 1995, PRVT plantings were established in Kentucky (Princeton, Ky.), Louisiana, North Carolina, Oregon, and South Carolina. In 1998, a second planting was established in Kentucky (Frankfort, Ky.). 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30060543]").text(description); $(".js-view-count-work_30060543").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30060543").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30060543"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment 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href="https://www.academia.edu/6416486/Decitabine_improves_patient_outcomes_in_myelodysplastic_syndromes_Results_of_a_phase_III_randomized_study">Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">BACKGROUNDAberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6416486" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">BACKGROUNDAberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.METHODSA total of 170 patients with MDS were randomized to receive either decitabine at a dose of 15 mg/m2 given intravenously over 3 hours every 8 hours for 3 days (at a dose of 135 mg/m2 per course) and repeated every 6 weeks, or best supportive care. Response was assessed using the International Working Group criteria and required that response criteria be met for at least 8 weeks.A total of 170 patients with MDS were randomized to receive either decitabine at a dose of 15 mg/m2 given intravenously over 3 hours every 8 hours for 3 days (at a dose of 135 mg/m2 per course) and repeated every 6 weeks, or best supportive care. Response was assessed using the International Working Group criteria and required that response criteria be met for at least 8 weeks.RESULTSPatients who were treated with decitabine achieved a significantly higher overall response rate (17%), including 9% complete responses, compared with supportive care (0%) (P < .001). An additional 12 patients who were treated with decitabine (13%) achieved hematologic improvement. Responses were durable (median, 10.3 mos) and were associated with transfusion independence. Patients treated with decitabine had a trend toward a longer median time to acute myelogenous leukemia (AML) progression or death compared with patients who received supportive care alone (all patients, 12.1 mos vs. 7.8 mos [P = 0.16]; those with International Prognostic Scoring System intermediate-2/high-risk disease, 12.0 mos vs. 6.8 mos [P = 0.03]; those with de novo disease, 12.6 mos vs. 9.4 mos [P = 0.04]; and treatment-naive patients, 12.3 mos vs. 7.3 mos [P = 0.08]).Patients who were treated with decitabine achieved a significantly higher overall response rate (17%), including 9% complete responses, compared with supportive care (0%) (P < .001). An additional 12 patients who were treated with decitabine (13%) achieved hematologic improvement. Responses were durable (median, 10.3 mos) and were associated with transfusion independence. Patients treated with decitabine had a trend toward a longer median time to acute myelogenous leukemia (AML) progression or death compared with patients who received supportive care alone (all patients, 12.1 mos vs. 7.8 mos [P = 0.16]; those with International Prognostic Scoring System intermediate-2/high-risk disease, 12.0 mos vs. 6.8 mos [P = 0.03]; those with de novo disease, 12.6 mos vs. 9.4 mos [P = 0.04]; and treatment-naive patients, 12.3 mos vs. 7.3 mos [P = 0.08]).CONCLUSIONSDecitabine was found to be clinically effective in the treatment of patients with MDS, provided durable responses, and improved time to AML transformation or death. The duration of decitabine therapy may improve these results further. Cancer 2006. © 2006 American Cancer Society.Decitabine was found to be clinically effective in the treatment of patients with MDS, provided durable responses, and improved time to AML transformation or death. The duration of decitabine therapy may improve these results further. Cancer 2006. © 2006 American Cancer Society.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6416486" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e632da370270bf67263349aa7f0e7b87" rel="nofollow" data-download="{"attachment_id":48876699,"asset_id":6416486,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48876699/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10098778" href="https://independent.academia.edu/HSaba">Hussain Saba</a><script data-card-contents-for-user="10098778" type="text/json">{"id":10098778,"first_name":"Hussain","last_name":"Saba","domain_name":"independent","page_name":"HSaba","display_name":"Hussain Saba","profile_url":"https://independent.academia.edu/HSaba?f_ri=424295","photo":"https://0.academia-photos.com/10098778/3418214/4019876/s65_hussain.saba.jpg"}</script></span></span></li><li class="js-paper-rank-work_6416486 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6416486"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6416486, container: ".js-paper-rank-work_6416486", }); });</script></li><li class="js-percentile-work_6416486 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 6416486; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_6416486"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_6416486 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="6416486"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 6416486; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=6416486]").text(description); $(".js-view-count-work_6416486").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_6416486").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="6416486"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4482" href="https://www.academia.edu/Documents/in/Palliative_Care">Palliative Care</a>, <script data-card-contents-for-ri="4482" type="text/json">{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="59057" href="https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia">Acute Myeloid Leukemia</a><script data-card-contents-for-ri="59057" type="text/json">{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=6416486]'), work: {"id":6416486,"title":"Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study","created_at":"2014-03-14T18:37:03.904-07:00","url":"https://www.academia.edu/6416486/Decitabine_improves_patient_outcomes_in_myelodysplastic_syndromes_Results_of_a_phase_III_randomized_study?f_ri=424295","dom_id":"work_6416486","summary":"BACKGROUNDAberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.METHODSA total of 170 patients with MDS were randomized to receive either decitabine at a dose of 15 mg/m2 given intravenously over 3 hours every 8 hours for 3 days (at a dose of 135 mg/m2 per course) and repeated every 6 weeks, or best supportive care. Response was assessed using the International Working Group criteria and required that response criteria be met for at least 8 weeks.A total of 170 patients with MDS were randomized to receive either decitabine at a dose of 15 mg/m2 given intravenously over 3 hours every 8 hours for 3 days (at a dose of 135 mg/m2 per course) and repeated every 6 weeks, or best supportive care. Response was assessed using the International Working Group criteria and required that response criteria be met for at least 8 weeks.RESULTSPatients who were treated with decitabine achieved a significantly higher overall response rate (17%), including 9% complete responses, compared with supportive care (0%) (P \u003c .001). An additional 12 patients who were treated with decitabine (13%) achieved hematologic improvement. Responses were durable (median, 10.3 mos) and were associated with transfusion independence. Patients treated with decitabine had a trend toward a longer median time to acute myelogenous leukemia (AML) progression or death compared with patients who received supportive care alone (all patients, 12.1 mos vs. 7.8 mos [P = 0.16]; those with International Prognostic Scoring System intermediate-2/high-risk disease, 12.0 mos vs. 6.8 mos [P = 0.03]; those with de novo disease, 12.6 mos vs. 9.4 mos [P = 0.04]; and treatment-naive patients, 12.3 mos vs. 7.3 mos [P = 0.08]).Patients who were treated with decitabine achieved a significantly higher overall response rate (17%), including 9% complete responses, compared with supportive care (0%) (P \u003c .001). An additional 12 patients who were treated with decitabine (13%) achieved hematologic improvement. Responses were durable (median, 10.3 mos) and were associated with transfusion independence. Patients treated with decitabine had a trend toward a longer median time to acute myelogenous leukemia (AML) progression or death compared with patients who received supportive care alone (all patients, 12.1 mos vs. 7.8 mos [P = 0.16]; those with International Prognostic Scoring System intermediate-2/high-risk disease, 12.0 mos vs. 6.8 mos [P = 0.03]; those with de novo disease, 12.6 mos vs. 9.4 mos [P = 0.04]; and treatment-naive patients, 12.3 mos vs. 7.3 mos [P = 0.08]).CONCLUSIONSDecitabine was found to be clinically effective in the treatment of patients with MDS, provided durable responses, and improved time to AML transformation or death. The duration of decitabine therapy may improve these results further. Cancer 2006. © 2006 American Cancer Society.Decitabine was found to be clinically effective in the treatment of patients with MDS, provided durable responses, and improved time to AML transformation or death. The duration of decitabine therapy may improve these results further. Cancer 2006. © 2006 American Cancer Society.","downloadable_attachments":[{"id":48876699,"asset_id":6416486,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10098778,"first_name":"Hussain","last_name":"Saba","domain_name":"independent","page_name":"HSaba","display_name":"Hussain Saba","profile_url":"https://independent.academia.edu/HSaba?f_ri=424295","photo":"https://0.academia-photos.com/10098778/3418214/4019876/s65_hussain.saba.jpg"}],"research_interests":[{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=424295","nofollow":false},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=424295","nofollow":false},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=424295","nofollow":false},{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia?f_ri=424295","nofollow":false},{"id":67422,"name":"Myelodysplastic Syndrome","url":"https://www.academia.edu/Documents/in/Myelodysplastic_Syndrome?f_ri=424295"},{"id":121665,"name":"DNA methylation","url":"https://www.academia.edu/Documents/in/DNA_methylation?f_ri=424295"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=424295"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28362367" data-work_id="28362367" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28362367/Demography_and_conservation_of_the_White_tailed_Tropicbird_Phaethon_lepturus_on_Aride_Island_Western_Indian_Ocean">Demography and conservation of the White-tailed Tropicbird Phaethon lepturus on Aride Island, Western Indian Ocean</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28362367" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bdb02580db80d42098fdbd0954299b6d" rel="nofollow" data-download="{"attachment_id":48696580,"asset_id":28362367,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48696580/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32186887" href="https://independent.academia.edu/JaimeRamos13">Jaime Ramos</a><script data-card-contents-for-user="32186887" type="text/json">{"id":32186887,"first_name":"Jaime","last_name":"Ramos","domain_name":"independent","page_name":"JaimeRamos13","display_name":"Jaime Ramos","profile_url":"https://independent.academia.edu/JaimeRamos13?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_28362367 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28362367"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28362367, container: ".js-paper-rank-work_28362367", }); });</script></li><li class="js-percentile-work_28362367 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x 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}); });</script></span><script>$(function() { $(".js-view-count-work_28362367").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28362367"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="173" href="https://www.academia.edu/Documents/in/Zoology">Zoology</a>, <script data-card-contents-for-ri="173" type="text/json">{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1091" href="https://www.academia.edu/Documents/in/Ornithology">Ornithology</a>, <script data-card-contents-for-ri="1091" type="text/json">{"id":1091,"name":"Ornithology","url":"https://www.academia.edu/Documents/in/Ornithology?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4392" href="https://www.academia.edu/Documents/in/Monte_Carlo_Simulation">Monte Carlo Simulation</a>, <script data-card-contents-for-ri="4392" type="text/json">{"id":4392,"name":"Monte Carlo Simulation","url":"https://www.academia.edu/Documents/in/Monte_Carlo_Simulation?f_ri=424295","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4753" href="https://www.academia.edu/Documents/in/Climate_variability">Climate variability</a><script data-card-contents-for-ri="4753" type="text/json">{"id":4753,"name":"Climate variability","url":"https://www.academia.edu/Documents/in/Climate_variability?f_ri=424295","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28362367]'), work: {"id":28362367,"title":"Demography and conservation of the White-tailed Tropicbird Phaethon lepturus on Aride Island, Western Indian Ocean","created_at":"2016-09-09T02:43:41.680-07:00","url":"https://www.academia.edu/28362367/Demography_and_conservation_of_the_White_tailed_Tropicbird_Phaethon_lepturus_on_Aride_Island_Western_Indian_Ocean?f_ri=424295","dom_id":"work_28362367","summary":null,"downloadable_attachments":[{"id":48696580,"asset_id":28362367,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32186887,"first_name":"Jaime","last_name":"Ramos","domain_name":"independent","page_name":"JaimeRamos13","display_name":"Jaime Ramos","profile_url":"https://independent.academia.edu/JaimeRamos13?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=424295","nofollow":false},{"id":1091,"name":"Ornithology","url":"https://www.academia.edu/Documents/in/Ornithology?f_ri=424295","nofollow":false},{"id":4392,"name":"Monte Carlo Simulation","url":"https://www.academia.edu/Documents/in/Monte_Carlo_Simulation?f_ri=424295","nofollow":false},{"id":4753,"name":"Climate variability","url":"https://www.academia.edu/Documents/in/Climate_variability?f_ri=424295","nofollow":false},{"id":48814,"name":"Indian Ocean","url":"https://www.academia.edu/Documents/in/Indian_Ocean?f_ri=424295"},{"id":240379,"name":"Indian Ocean Dipole","url":"https://www.academia.edu/Documents/in/Indian_Ocean_Dipole?f_ri=424295"},{"id":362525,"name":"Habitat management","url":"https://www.academia.edu/Documents/in/Habitat_management?f_ri=424295"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=424295"},{"id":533274,"name":"Growth rate","url":"https://www.academia.edu/Documents/in/Growth_rate?f_ri=424295"},{"id":572222,"name":"Population Decline","url":"https://www.academia.edu/Documents/in/Population_Decline?f_ri=424295"},{"id":892124,"name":"Southern Oscillation","url":"https://www.academia.edu/Documents/in/Southern_Oscillation?f_ri=424295"},{"id":1157748,"name":"Breeding Success","url":"https://www.academia.edu/Documents/in/Breeding_Success?f_ri=424295"},{"id":1564348,"name":"Matrix Model","url":"https://www.academia.edu/Documents/in/Matrix_Model?f_ri=424295"},{"id":1957240,"name":"ENVIRONMENTAL SCIENCE AND MANAGEMENT","url":"https://www.academia.edu/Documents/in/ENVIRONMENTAL_SCIENCE_AND_MANAGEMENT?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_8105375" data-work_id="8105375" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/8105375/Evaluation_of_the_Performance_of_a_Modified_Acute_Physiology_and_Chronic_Health_Evaluation_APACHE_II_Scoring_System_for_Critically_Ill_Patients_in_Emergency_Departments_in_Hong_Kong">Evaluation of the Performance of a Modified Acute Physiology and Chronic Health Evaluation (APACHE II) Scoring System for Critically Ill Patients in Emergency Departments in Hong Kong</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" 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InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="15718535" href="https://unam1.academia.edu/PaulinaColin">Paulina Colin</a><script data-card-contents-for-user="15718535" type="text/json">{"id":15718535,"first_name":"Paulina","last_name":"Colin","domain_name":"unam1","page_name":"PaulinaColin","display_name":"Paulina Colin","profile_url":"https://unam1.academia.edu/PaulinaColin?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_8105375 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="8105375"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 8105375, container: ".js-paper-rank-work_8105375", }); });</script></li><li 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Kong","created_at":"2014-08-27T11:38:17.153-07:00","url":"https://www.academia.edu/8105375/Evaluation_of_the_Performance_of_a_Modified_Acute_Physiology_and_Chronic_Health_Evaluation_APACHE_II_Scoring_System_for_Critically_Ill_Patients_in_Emergency_Departments_in_Hong_Kong?f_ri=424295","dom_id":"work_8105375","summary":null,"downloadable_attachments":[{"id":48213183,"asset_id":8105375,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":15718535,"first_name":"Paulina","last_name":"Colin","domain_name":"unam1","page_name":"PaulinaColin","display_name":"Paulina Colin","profile_url":"https://unam1.academia.edu/PaulinaColin?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":25021,"name":"Hong Kong","url":"https://www.academia.edu/Documents/in/Hong_Kong?f_ri=424295","nofollow":false},{"id":62112,"name":"Prospective 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data-work_id="9270425" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9270425/Long_term_survival_after_aortic_valve_replacement_for_native_active_infective_endocarditis">Long-term survival after aortic valve replacement for native active infective endocarditis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The objective of this study was to analyse the impact of acute surgery for native aortic valve endocarditis and its influence on the long-term prognosis after surgery. Methods: A total of 161 patients underwent aortic valve... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_9270425" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The objective of this study was to analyse the impact of acute surgery for native aortic valve endocarditis and its influence on the long-term prognosis after surgery. Methods: A total of 161 patients underwent aortic valve replacement for native active aortic valve endocarditis (NAAVE) during a 29-year period, from 1967 to 1995 (age range: 10 to 72 years; mean 48 ± 12). The main indication for surgery was progressive congestive heart failure (76%). Other indications were unbeatable sepsis (27%), peripheral or central emboli (12%) and, from 1978, echocardiographic evidence of friable, pedunculated vegetations (3%). Streptococcal and staphylococcal infections predominated. Concomitant procedures were performed in 27% of the patients, including mitral and tricuspid valve surgery and coronary bypass procedures. Results: Operative mortality was 8% in the majority of cases caused by heart failure or multiorgan failure. Multivariate logistic regression analysis identified NYHA class IV to be an independent predictor for postoperative death. Long-term survival for discharged patients was 75% at 10 years and 58% at 15 years, with a mortality rate of 3.6%/patient/year. Cox regression analysis identified the year of operation, trivalvular endocarditis and staphylococcal infection as independent predictors of survival. At 10 and 15 years after aortic valve replacement, 91% and 84% of the patients, respectively, were free of recurrent endocarditis. The presence of an abscess cavity at first operation was found to be predictive of recurrent endocarditis. Conclusions: Valve replacement for NAAVE offers a good chance for a cure and satisfactory long-term survival. Improvements in pre- and per-op-rative management of the very ill patient, and the use of allograft valves are likely to further improve long-term results. Finally, the presence of staphylococcal endocarditis requires long-term postoperative antibiotic therapy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9270425" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ec5bb604e6b45a48ffc86d7b9df9b9ba" rel="nofollow" data-download="{"attachment_id":47835598,"asset_id":9270425,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47835598/download_file?st=MTczMzAwODA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="21312840" href="https://independent.academia.edu/MohamedAmrani5">Mohamed Amrani</a><script data-card-contents-for-user="21312840" type="text/json">{"id":21312840,"first_name":"Mohamed","last_name":"Amrani","domain_name":"independent","page_name":"MohamedAmrani5","display_name":"Mohamed Amrani","profile_url":"https://independent.academia.edu/MohamedAmrani5?f_ri=424295","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9270425 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9270425"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9270425, container: ".js-paper-rank-work_9270425", }); 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Methods: A total of 161 patients underwent aortic valve replacement for native active aortic valve endocarditis (NAAVE) during a 29-year period, from 1967 to 1995 (age range: 10 to 72 years; mean 48 ± 12). The main indication for surgery was progressive congestive heart failure (76%). Other indications were unbeatable sepsis (27%), peripheral or central emboli (12%) and, from 1978, echocardiographic evidence of friable, pedunculated vegetations (3%). Streptococcal and staphylococcal infections predominated. Concomitant procedures were performed in 27% of the patients, including mitral and tricuspid valve surgery and coronary bypass procedures. Results: Operative mortality was 8% in the majority of cases caused by heart failure or multiorgan failure. Multivariate logistic regression analysis identified NYHA class IV to be an independent predictor for postoperative death. Long-term survival for discharged patients was 75% at 10 years and 58% at 15 years, with a mortality rate of 3.6%/patient/year. Cox regression analysis identified the year of operation, trivalvular endocarditis and staphylococcal infection as independent predictors of survival. At 10 and 15 years after aortic valve replacement, 91% and 84% of the patients, respectively, were free of recurrent endocarditis. The presence of an abscess cavity at first operation was found to be predictive of recurrent endocarditis. Conclusions: Valve replacement for NAAVE offers a good chance for a cure and satisfactory long-term survival. Improvements in pre- and per-op-rative management of the very ill patient, and the use of allograft valves are likely to further improve long-term results. Finally, the presence of staphylococcal endocarditis requires long-term postoperative antibiotic therapy.","downloadable_attachments":[{"id":47835598,"asset_id":9270425,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":21312840,"first_name":"Mohamed","last_name":"Amrani","domain_name":"independent","page_name":"MohamedAmrani5","display_name":"Mohamed Amrani","profile_url":"https://independent.academia.edu/MohamedAmrani5?f_ri=424295","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4366,"name":"Cardiovascular","url":"https://www.academia.edu/Documents/in/Cardiovascular?f_ri=424295","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=424295","nofollow":false},{"id":40862,"name":"Belgium","url":"https://www.academia.edu/Documents/in/Belgium?f_ri=424295","nofollow":false},{"id":49633,"name":"Heart 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replacement","url":"https://www.academia.edu/Documents/in/Valve_replacement?f_ri=424295"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27419313" data-work_id="27419313" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27419313/Finding_what_is_not_there_Unwarranted_claims_of_an_effect_of_psychosocial_intervention_on_recurrence_and_survival">Finding what is not there: Unwarranted claims of an effect of psychosocial intervention on recurrence and survival</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" 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href="https://www.academia.edu/25506010/Immunoglobulin_isotypes_in_multiple_myeloma_laboratory_correlates_and_prognostic_implications_in_total_therapy_protocols">Immunoglobulin isotypes in multiple myeloma: laboratory correlates and prognostic implications in total therapy protocols</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25506010" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fdd7e194c75c7bc4b6c02180d7a2bc40" rel="nofollow" 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