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<!DOCTYPE html> <html lang="en"> <head> <link rel="stylesheet" type="text/css" href="https://faculty.uci.edu/css/header.css"/> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css"> <link rel="stylesheet" type="text/css" href="https://faculty.uci.edu/css/main.css"/> <link rel="stylesheet" type="text/css" href="https://faculty.uci.edu/css/additional.css"/> </head> <body> <div id="container"> <div id="header"> <meta charset="utf-8"> <meta name="description" content="fps"> <meta name="viewport" content="width=device-width"> <title>UC Irvine - Faculty Profile System</title> <a href="https://faculty.uci.edu/"> <img src="https://faculty.uci.edu/images/sitelogo.svg" alt="UCI Faculty Profile System"> </a> <div class="topnav" id="myTopnav"> <a title="For Faculty" href="https://faculty.uci.edu/forFaculty">For Faculty</a> <a title="Help" href="https://faculty.uci.edu/help">Search Tips</a> <a title="About" href="https://faculty.uci.edu/about">About</a> <a href="javascript:void(0);" class="icon" onclick="toggleNavbar()"> <i class="fa fa-bars"></i> </a> </div> </div> <div id="content"> <div id="profile"> <h2>Shengwen Calvin Li,PhD,M.Phil.,EIC,FRSB,FRSM</h2> <div id="fImage"> <img src="https://faculty.uci.edu/get_image?facultyId=5952" alt="Picture of Shengwen Calvin Li,PhD,M.Phil.,EIC,FRSB,FRSM"> </div> <div id="academic" class="profile-section"> <div class="profile-section-item"> Editor-in-Chief of World Journal of Stem Cells (IF:5.326). Principal Investigator/Scientist,CHOC Children's Research Institute, Children's Hospital of Orange County (CHOC), Neuro-Oncology and Stem Cell Research Laboratory, Neurology<br>School of Medicine </div> <div class="profile-section-item"> Adjunct Professor, California State University, Fullerton (2007- </div> <div class="profile-section-item"> Visiting Professor, Sun Yat-sen University (2010-) </div> <div class="profile-section-item"> Assistant Professor (tenure track), Thomas Jefferson University (2006-2007) </div> <div class="profile-section-item"> Senior Scientist/Group Leader, AbbVie/Allergan, Inc. (1998-2005) </div> <div class="profile-section-item"> Associate Project Scientist, Neurology<br>School of Medicine </div> </div> <div id="degrees" class="profile-section"> Ph.D., Mount Sinai School of Medicine, New York, NY, Biomedical Science with Saul Puszkin, PhD <br> Postdoctoral Fellowship, Massachusetts Institute of Technology (MIT)/Whitehead Institute for Biomedical Research, Postdoctoral Fellowship with Michael P. Lisanti, MD-PhD <br> Research Fellowship, Harvard Medical School, Boston, MA, Department of Cell Biology with Joan S. Brugge, PhD <br> </div> <div id="contact-info" class="profile-section"> Phone: (714)509-4964 <br> Fax: (714)509-4318 <br> Email: <a href="mailto:shengwel@hs.uci.edu; SLI@CHOC.ORG; shengwen.li@alumni.mssm.edu">shengwel@hs.uci.edu; SLI@CHOC.ORG; shengwen.li@alumni.mssm.edu</a> <br> </div> <div id="address" class="profile-section"> University of California, Irvine <br> 1201 West La Veta Avenue <br> CHOC Children's Hospital Research Institute <br> Mail Code: 4292 <br> Orange, CA 92868 <br> </div> <div id="research-interests" class="profile-section"> <strong>Research Interests</strong> <br> <div class="profile-section-item"> brain tumors, cancer stem cells, immunotherapy, neural stem cells, iPSCs (induced pluripotent stem cells), cancer vaccine, tissue scaffold, organoid, tumor microenvironment, single cell transcriptome, Neurotoxin, BOTOX, Caveolin, Caveolae, AI Medicine.. </div> </div> <div id="Websites" class="profile-section"> <strong>Websites</strong> <br> <div class="profile-section-item"> <a href="https://www.choc.org/findadoc/index.cfm?id=P00348&pid=1636&bio=research"> www.choc.org/findadoc/index.cfm?id=P00348&pid=1636&bio=research </a> </div> <div class="profile-section-item"> <a href="https://publons.com/author/1176194/shengwen-calvin-li-phd#stats"> Peer-Review Record </a> </div> <div class="profile-section-item"> <a href="https://orcid.org/0000-0002-9699-9204"> ORCID (Open Researcher and Contributor ID) </a> </div> <div class="profile-section-item"> <a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1lotw2j42xNkx/bibliography/44841196/public/?sort=date&direction=ascending"> US NCBI (National Center for Biotechnology Information) My Bibliography </a> </div> <div class="profile-section-item"> <a href="https://www.researchgate.net/profile/Shengwen_Li/?ev=hdr_xprf"> Research Gate - list of publications </a> </div> </div> <div id="academic-distinctions" class="profile-section"> <strong>Academic Distinctions</strong> <br> <div class="profile-section-item"> Dr. Li’s pioneering work is among the most-frequently-cited (cited in 1000+ articles per one publication), and remarked in articles published in Nature, Cell, and Annual Review of Cell and Developmental Biology. He has published numerous research articles, reviews, chapters, and patents. <br>He has served on the editorial boards for the American Journal of Pathology (Official Journal of the American Society for Investigative Pathology (ASIP))(2008-2016, Elsevier Publisher), Current Stem Cell & Therapy (Bentham Scientific Publishing)(2014-), The World Journal of Stem Cells (2012-)(as Editor-in-Chief, 2019-now, California, USA), PLOS ONE (Academic Editor, 2019-now; San Francisco, CA, USA), Frontiers in Oncology (Associate Editor, 2020-now, Frontiers Media PLC, Switzerland), Cancer Control (Section Editor, SAGE Publishing, London, U.K., 2022-now), Journal of Cell Science and Therapy (2012-). He has been an ad-hoc reviewer for grant agencies and journals, including Cancer Immunology Immunotherapy, The Alzheimer’s Society’s Quality Research in Dementia, Nature Medicine, and Journal of Biological Chemistry, PLoS One, BMC Regerative medicine, BMC Neuroradiology, Stem Cells and Development, Stem Cells, BMC Cell and Bioscience, Technology in Cancer Research and Treatment, Cell Biology International (journal published by Portland Press for the International Federation for Cell Biology). February – June 21, 2023, served as Ad-Hoc Reviewer, external review for France’s Inserm cancer grant proposals <br>Abiodoun Ibrahim SADISSOU,PhD <br>Chargé de mission appels à projets Plan Cancer et Stratégie Décennale Cancer <br>Inserm | Département de l’Evaluation et du Suivi des Programmes (DESP) <br>101 Rue de Tolbiac | 75013 Paris, France <br> Induction to the Sigma Xi, The Scientific Research Honor Society (founded in 1886). <br> <br>Honors: <br>2023 Induction to the Sigma Xi, The Scientific Research Honor Society (founded in 1886) <br>2023 Theranostics (IF 12.4) Cover of the Journal Issue, Theranostics (IF 12.4) 2023;13(12):3943-3963. doi: 10.7150/thno.83178. eCollection 2023. PubMed PMID: 37554265; PubMed Central PMCID: PMC10405834. <br>2022 Cover Theranostics (IF 12.4) 2022;12(4):1621-1638. doi: 10.7150/thno.64963. eCollection 2022. PubMed PMID: 35198061; PubMed Central PMCID: PMC8825582. <br>2021 elected fellow, The Royal Society of Biology, U.K. <br>2021 Excellent Reviewer* (Web of Science, Publons Academy, Clarivate Plc) (British-American publicly traded analytics company that operates a collection of subscription-based services) <br>2019 Web of Science/Publons’ Global Peer-Review Award (Top 1% in Field) <br>2018.9 Web of Science/Publons’ Global Peer-Review Award (Top 1% in Field, Rank #27 in global Peer-review of Molecular biology and genetics, 2018) (Owner: Clarivate Analytics - The Intellectual Property and Science business of Thomson Reuter, including Web of Science, Cortellis, Derwent Innovation, Derwent World Patents Index, CompuMark, MarkMonitor, Techstreet, Publons, EndNote, and Kopernio) <br>2014 Top 10, most-accessed Cancer Cell International articles <br>2015 The 1st CHOC Children's-UC Irvine Pediatric Research Joint Award <br>2016 CHOC-UCI Traumatic Brain Injury Research Pilot Grant Award <br>2018- Elected overseas fellow, The Royal Society of Medicine, The United Kingdom of Great British <br>2012 Most-accessed Cancer Cell International Journal article <br>2011 PNAS Cover paper and commented in “Research Highlight”, Proceedings of the National Academy of Sciences USA <br>2011 Research Highlight and Feature in Journal BioTechniques (Journal-Stem Cell Reviews and Reports) <br>2009 Top 100 Inventors - Patent application (http://www.faqs.org/patents/invl/00090) <br>2009 The 5th Annual Poe Symposium First Speaker, California State University Channel Islands. <br>2009 Mentor distinction for student research award, California State University Fullerton <br>2009 Patent Publications (United States Patent and International Patent Applications, Ranked #2,144 of 298,449 inventors worldwide, 2009/February, http://www.faqs.org/patents/invl/lg) <br>2008 Top 10, most-accessed Cancer Cell International articles <br>2007 Mentor distinction: One high school student won the US Siemens Competition in Science, Technology, and Mathematics (National, individual) <br>2007 Mentor distinction for Sherrie Yu, CHOC Golden Bear Paw award winner (CHOC honor) <br>2006 Austin Ford Tribute Fund and W.M. Keck Foundation <br>2006 Top 40, most-frequently-cited paper, Journal of Biological Chemistry (JBC) articles <br>2005-present Research Award, CHOC Foundation for Children <br>2005 Top 40, most-frequently-cited paper, Journal of Biological Chemistry articles <br>2004 Top 50 Most-Frequently-Cited JBC Articles (#49). <br>2003 Certificate of Special Recognition for the year 2003 honoring the excellence of Allergan, Inc. Authors and Inventors in recognition of contributions to the R & D efforts <br>2002 Certificate of Special Recognition for the year 2002 honoring the excellence of Allergan, Inc. Authors and Inventors in recognition of contributions to the R & D efforts <br>2003 “Science Skte” comment and citation for one article <br>2001 “Cell” citations for 4 articles <br>1996 “Nature” citations for 2 articles (Comment in Research Progress) <br>1996-1999 NIH/NCI Individual National Research Service Award (1996-1999). <br>1996 China Bridge International Fellowship (1996) (was named “China-Cornell Fellowship, funded by the Rockefeller Foundation and Lingnan University Alumnae Association. Program Directors: Xiangzhong (Jerry) Yang, Ray Wu). <br>1996 Sun Yat-sen University, Visiting Scholarship, 1996. <br>1996 Research Scholarship, Chinese Ministry of High Education and National Natural Research Foundation, 1996. <br>1994 Dissertation Research Award, Mount Sinai School of Medicine, 1994, NY. <br>1994 Travel Award for Young Investigator (American Society of Neurochemistry, 1994) <br>1990 University Tuition Scholarship Award for Research in Ecology, Evolution, and Behavior Program). CUNY, 1990, NY. <br> <br>REPRESENTATIVE RESEARCH ARTICLES with HIGHLIGHTS: <br> <br>Li SC*(*corresponding author, primary), Y.Jin, W.G. Loudon, Y.Song, Z.Ma, L.P. Weiner, and J.F. Zhong. From the Cover: Increase developmental plasticity of human keratinocytes with gene suppression. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12793-8. Epub 2011 Jul 18. PubMed PMID: 21768375; PubMed Central PMCID: PMC3150912. (Comment on Cover and in Research Highlights) <br> <br>Li SC*(*corresponding author), Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. (2012) Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 2012(1):41. [Epub ahead of print]. PMID: 22995409. [PubMed] (Most-accessed: 2457 access) <br> <br>Li SC *(* corresponding author), Lee KL, Luo J, Zhong JF, Loudon WG. (On the Cover -- http://www.wjgnet.com/1948-0210/index.htm) -- Convergence of normal stem cell and cancer stem cell developmental stage: Implication for differential therapies. World J Stem Cells 2011; 3(9): ISSN 1948-0210 (online) <br> <br>Li S, Okamoto T, Chun M, Sargiacomo M, Casanova J, Hansen SH, Nishimoto I, and Lisanti MP (1995). Evidence for a regulated interaction between hetrotrimeric G proteins and Caveolin. J. Biol. Chem. (USA), 270 (26): 15693-15701 <br> For the first time, we established that caveolin acts as a negative regulator for signal transduction. We have also established the model system for studying functional interaction of caveolin with signaling molecules. <br> ("** Of outstanding interest" as cited by Parton RG. in "Current Opinions in Cell Biology" 1996, 8: 542-548. <br> Cited by Kai Simons and Elina Ikonen, Research Progress: Functional rafts in cell membrane, Nature 387, 569-572, ref. 47, 5 JUNE 1997 in Research Progress. <br> Cited in 791 papers (1995-2005, 10 years) <br> (2005 Top 40 Most-Frequently-Cited JBC Articles, See www.jbc.org/reports/mfc8.dtl) <br> The most-frequently-cited research paper of “The 2005 Ranked # 15 World-wide of Most-Cited Researchers (Michael P. Lisanti) in Biochemistry & Biology (THOMSON ISI), Based on Impact Factors, See www.in-cites.com/nobel/2005-bio-top100.html” (Ten-year 1995-2005 period) <br> <br>Li S, Couet J, and Lisanti MP (1996). Src tyrosine kinases, G? subunits and H-Ras share a common membrane-anchored scaffolding protein, Caveolin: Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J. Biol. Chem. (USA) 271 (46): 29182-29190. <br> Identification of Caveolin-Scaffolding Domain-CSD, a new term well adopted in literature <br> Further data supporting the therapeutic application of CSD in pathological conditions <br> Cited by Thomas SM and Brugge JS, 1997. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 1997. 13: 513-609. 1997 by Annual Reviews Inc. <br> "** Of special interest" as cited by Harold A Chapman, Plasminogen activators, Integrin, and the coordinated regulation of cell adhesion and migration, in "Current Opinions in Cell Biology" 1997, 9: 714-724, Ref. 46; <br> Cited by 649 (Google Scholar, 2.07.2012) <br> Cited by Bucci et al. (2000), NATURE MEDICINE • VOL. 6 • No. 12: pp1362-7 • DECEMBER 2000 <br> <br>Song KS, Li S, Okamoto T, Quilliam LA, Sargiacomo M, and Lisanti MP (1996). Co-purification and direct interaction of Ras with Caveolin, an integral membrane protein of caveolae microdomains: A novel procedure of detergent-free purification for caveolae membrane. J. Biol. Chem. (USA), 271(16), 9690-9697. <br> First evidence for existence of Ras in caveolae, interaction of Caveolin with H-Ras; <br> Provided a new method for purification of caveolae; <br> Cited by 948 papers (Google Scholar, Jan2012); <br> Cited by Kai Simons and Elina Ikonen, Research Progress: Functional rafts in cell membrane, Nature 387, 569-572, ref. 48, 5 JUNE 1997 in “Research Progress” <br> The most-frequently-cited research paper of “The 2006 Ranked # 13 World-wide of Most-Cited Researchers (Micheal P. Lisanti) in Biochemistry & Biology (THOMSON ISI), Based on Impact Factors, See www.in-cites.com/nobel/2005-bio-top100.html” (Ten-year 1996-2006 period) <br> 2004 Top 50 Most-Frequently-Cited JBC Articles (#49). <br> <br>Li S, Seitz R and Lisanti MP (1996). Phosphorylation of Caveolin by Src tyrosine kinases: The alpha-isoform of Caveolin is selectively phosphorylated by v-Src in vivo. J. Biol. Chem. (USA), 271(7), 3863-3868. (Cited by 235) <br> <br>Li S, Song KS and Lisanti MP (1996). Expression and characterization of recombinant Caveolin: Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes. J. Biol. Chem. (USA), 271(1), 568-573. (Cited by 189; Google scholar – Dec2011) <br> <br>Li S, Song KS, Koh SS and Lisanti MP (1996). Baculovirus-based expression of mammalian Caveolin in Sf21 insect cells: A model system for the biochemical and morphological study of caveolar biogenesis. J. Biol. Chem., (USA) 271 (45): 28647-28654. (Cited by 165 papers) <br> <br>García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem. 1997 Oct 10;272(41):25437-40. PubMed PMID: 9325253. Cited by 596 papers (Google Scholar, Jan2012); <br> <br>Couet J, Li S, Okamoto T, Ikezu T, and Lisanti MP (1997). Identification of Peptide and protein ligands for the Caveolin-scaffolding domain: Implication for the interaction of Caveolin-associated proteins. J. Biol. Chem. (USA) 272 (10): 6525-6533. (Identified Caveolin Binding Motif—CBM by phage display Cited by 688; Google Scholar- Dec2011) <br> <br>Zhang L*, Lin W*, Li S* (*equal contribution), and Aoki KR (2003). Complete DNA sequences of the Botulinum neurotoxin Type A-Hall (Allergan BOTOX®) Strain. Gene 315 (2003), 21-32. <br> <br>Wang H, Haas M, Liang M, Cai T, Tian J, Li S, and Xie Z (2004)**. Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase. J. Biol. Chem. (USA) 279, 17250-17259. (Editorial Comment in **News/Views in Science STKE, Science) (Cited by 123) <br> <br>Ju X , S Katiyar , C Wang , M Liu , X Jiao , J Zhou , J Turner, S Li, M Lisanti, R Russell , S Mueller , J Ojeifo , W. Chen , N Hay, R. Pestell (2007). Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A. 104 (18): 7438-7443. (Cited by 97) <br> <br>Li SC* (*corresponding author), Loudon WG (2008). A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors. Cancer Cell International 2008, 8:9. doi:10.1186/1475-2867-8-9. PMID: 18498656. (Top 10 most assessed articles, total #6514). <br> <br>Li SC* (*corresponding author), Tachiki L, Luo J, Dethlefs BA, Chen Z, Loudon WG (2010). A biological global positioning system: considerations for tracking stem cell behaviors in the whole body. Stem Cell Reviews and Reports, 6 (2): 317-333. (DOI: 10.1007/s12015-010-9130-9) (Thomas Reuters Impact Factor Index 6.774 (2010). <br>(Feature story: Commented by Jeffrey M. Perkel, Ph.D., BioTechniques Focus: Translational Tools – Special News Feature, “What lies beneath: In vivo stem cell imaging,” BioTechniques 50: 223-227 (April 2011) doi 10.2144/000113647) <br> <br>Song KS, Scherer PE, Tang Z, Okamoto T, Li S, Chafel M, Chu C, Kohtz DS, Lisanti MP. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem. 1996 Jun 21;271(25):15160-5. PubMed PMID: 8663016. (Cited by 517) </div> </div> <div id="appointments" class="profile-section"> <strong>Appointments</strong> <br> <div class="profile-section-item"> Complete List of Published Work in the US NCBI (National Center for Biotechnology Information) My Bibliography: <br> <br>Share your bibliography with this URL: <br>https://www.ncbi.nlm.nih.gov/sites/myncbi/1lotw2j42xNkx/bibliography/44841196/public/?sort=date&direction=ascending <br> <br>https://www.ncbi.nlm.nih.gov/ <br> <br>ORCID (Open Researcher and Contributor ID): https://orcid.org/0000-0002-9699-9204 <br> <br>Other Experience and Professional Memberships <br> <br>Other Experience <br>08/08-12/16 Member, Editorial Board, American Journal of Pathology ((Official Journal of American Society of Investigative Pathology - ASIP) <br>01/16-present Advisory board member for the journal, Current Stem Cell Research & Therapy (Bentham Science Publishers) <br>09/10-present Member, Editorial Board and Associate Editor, Journal of Stem Cell & Therapy <br>09/12-present Section Editor, Journal of Cell Science and Therapy <br>09/11-present Member, Editorial Board, World Journal of Stem Cells <br>11/16-present Member, Editorial Board, Quantitative Imaging in Medicine and Surgery (QIMS, Quant Imaging Med Surg, Print ISSN 2223-4292; Online ISSN 2223-4306) <br> <br>Ad-Hoc Reviewer <br> <br>ACS Applied Materials & Interfaces; Annu. Res. Rev. Biol.; Cancers – Switzerland; Cancer Immunology Immunotherapy (CII); Nature Medicine; International Journal of Molecular Sciences (IJMS); Journal of Biological Chemistry (JBC); Exp. Hematol. Oncol. (BMC); BMC Regenerative Medicine Research; BMC Neuroradiology; BMC Cell and Bioscience; BMC Cell Biology International; Journal of Hematology and Oncology – Editor-in-Chief: Liu Delong; Journal of Pediatric Neuroradiology; Journal of Personalized Med. (JPM); Journal of Stem Cell Research and Transplantation; Journal of Histotechnology; Journal of Schizophrenia Disorders Ther.; JoVE (J. Visualized Experiment); Journal of Solid Tumors; La Prensa Medica Argintina; Life Sciences; Molecules - mdpi – Switzerland; Molecular Cancer - mdpi – Switzerland; Molecular and Cellular Therapies; Neuroradiology, BMC; Neural Regeneration Research, China; Oncotarget (Editor-in-Chief: Mikhail V. Blagosklonny); OncoTargets and Therapy; PLoS One; Pharmacology & Therapeutics -UK; Stem Cell and Development; Technology in Cancer Research & Treatment; ); Teenage Young Adult Oncology; Translational Research (Elsevier); Science China Life Sciences (Springer), (http://www.mdpi.com/journal/ijms/,assessed May 14, 2017. <br>Grant review, The Alzheimer’s Society (U.K.); NIH Study Section; foundation grant proposals. <br> <br>Peer-Review Record: https://publons.com/author/1176194/shengwen-calvin-li-phd#stats <br> <br>Memberships <br>2011-present Association for Clinical and Translational Science (ACTS) <br>2011-present Society for Translational and Clinical Sciences (STCS) <br> International Society for Stem Cell Research (ISSCR) <br> Society for Neuroscience (SfN) <br> American Society for Cell Biology (ASCB) <br> American Association for the Advancement of Science (AAAS) <br> American Society for Investigative Pathology (ASIP). <br>2017.12.15/2018.4.23 Invited membership to The Royal Society of Medicine, The United Kingdom of Great British </div> </div> <div id="research-abstract" class="profile-section"> <strong>Research Abstract</strong> <br> <div class="profile-section-item"> Dr. Li’s research goal is to develop novel cancer therapies by determining the optimal therapeutic windows for the targeted destruction of cancer stem cells. Working with physicians, Dr. Li has taken a systematic approach to uncovering the therapeutic window. By isolating and characterizing cancer stem cells, he tracks the molecular mechanism of the cells’ trafficking as they metastasize and grow in the three-dimensional microenvironment with an engineer-designed tissue and/or synthetic polymer scaffold. Through this tunable matrix medium, he studies the cellular, molecular, and physiological parameters of therapeutic window for targeted destruction of cancer, aiming at the personalized treatment of patients. </div> </div> <div id="publications" class="profile-section"> <strong>Publications</strong> <br> <div class="profile-section-item"> Chai C, Sui K, Tang J, Yu H, Yang C, Zhang H, Li SC, Zhong JF, Wang Z, Zhang X. BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications imply therapies of leukemic subclonal evolution. Theranostics. 2023;13(12):3943-3963. doi: 10.7150/thno.83178. eCollection 2023. PubMed PMID: 37554265; PubMed Central PMCID: PMC10405834. </div> <div class="profile-section-item"> Li SC. Mastering the craft: Creating an insightful and widely-cited literature review. World J Stem Cells. 2023 Aug 26;15(8):781-786. doi: 10.4252/wjsc.v15.i8.781. PubMed PMID: 37700820; PubMed Central PMCID: PMC10494571. </div> <div class="profile-section-item"> Miao Y, Chen Z, Li SC. Functional endoscopy techniques for tracking stem cell fate. Quant Imaging Med Surg. 2019 Mar;9(3):510-520. doi: 10.21037/qims.2019.02.12.PMID: 31032197 </div> <div class="profile-section-item"> Li SC, Luo J, Lee KL. Cancer Niche as a Garbage Disposal Machine: Implications of TCM-Mediated Balance of Body-Disease for Treatment of Cancer. <br>Online J Complement Altern Med. 2019;1(3). pii: 000514. doi: 10.33552/OJCAM.2019.01.000514. Epub 2019 Jun 11.PMID: 31453571 </div> <div class="profile-section-item"> Li SC, Rangel AD, Kabeer MH. Precision Technique for Splenectomy Limits Mouse Stress Responses for Accurate and Realistic Measurements for Investigating Inflammation and Immunity. <br>Bio Protoc. 2019 Aug 5;9(15). pii: e3317. doi: 10.21769/BioProtoc.3317. PMID: 31497622 </div> <div class="profile-section-item"> Ran Q, Jin F, Xiang Y, Xiang L, Wang Q, Li F, Chen L, Zhang Y, Wu C, Zhou L, Xiao Y, Chen L, Wu J, Zhong JF, Li SC, Li Z. <br>CRIF1 as a potential target to improve the radiosensitivity of osteosarcoma. <br>Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20511-20516. doi: 10.1073/pnas.1906578116. Epub 2019 Sep 23. PMID: 31548420 </div> <div class="profile-section-item"> Li, S.C.; Sparks, K.J.; Sender, L.S. Implementation and Validation of the Roche Light Cycler 480 96-Well Plate Platform as a Real-Time PCR Assay for the Quantitative Detection of Cytomegalovirus (CMV) in Clinical Specimens Using the Luminex MultiCode ASRs System. Med. Sci. 2020, 8, 14. Med. Sci. 2020, 8(1), 14; https://doi.org/10.3390/medsci8010014 </div> <div class="profile-section-item"> Li SC (corresponding), Stucky A, Chen X, Kabeer MH, Loudon WG, Plant AS, Torno L, Nangia CS, Cai J, Zhang G, Zhong JF. (2018). Single-cell transcriptomes reveal the mechanism for a breast cancer prognostic gene panel. <br>Oncotarget. 2018 Sep 7;9(70):33290-33301. doi: 10.18632/oncotarget.26044. eCollection 2018 Sep 7. PMID: 30279960. Free PMC Article </div> <div class="profile-section-item"> Zhang, J.; Su, Q.; Loudon, W.G.; Lee, K.L.; Luo, J.; Dethlefs, B.A.; Li, S.C. Breathing Signature as Vitality Score Index Created by Exercises of Qigong: Implications of Artificial Intelligence Tools Used in Traditional Chinese Medicine. J. Funct. Morphol. Kinesiol. 2019, 4, 71.doi: 10.3390/jfmk4040071 </div> <div class="profile-section-item"> USPTO PAT. NO. Title <br>8,623,999 <br> <br>Modified Clostridial toxins with enhanced targeting capabilities for endogenous Clostridial toxin receptor systems <br> <br>8,518,417 <br> <br>Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity <br> <br>8,460,682 <br> <br>Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells <br> <br>8,273,865 <br> <br>Multivalent clostridial toxins <br> <br>8,273,358 <br> <br>Activatable clostridial toxins <br> <br>8,198,083 <br> <br>Organotypic slices of the central nervous system <br> <br>8,128,940 <br> <br>Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems <br> <br>8,071,110 <br> <br>Activatable clostridial toxins <br> <br>8,052,979 <br> <br>Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells <br> <br>8,021,859 <br> <br>Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells <br> <br>7,998,489 <br> <br>Degradable clostridial toxins <br> <br>7,993,656 <br> <br>Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells <br> <br>7,897,157 <br> <br>Activatable clostridial toxins <br> <br>7,892,565 <br> <br>Degradable clostridial toxins <br> <br>7,825,233 <br> <br>Optimizing expression of active Botulinum Toxin type E <br> <br>7,811,584 <br> <br>Multivalent clostridial toxins <br> <br>7,749,514 <br> <br>Activatable clostridial toxins <br> <br>7,740,868 <br> <br>Activatable clostridial toxins <br> <br>7,172,764 <br> <br>Rescue agents for treating botulinum toxin intoxications <br> <br>6,991,789 <br> <br>Methods of modulating intracellular degradation rates of toxins </div> <div class="profile-section-item"> Wu J, Zhang W, Ran Q, Xiang Y, Zhong JF, Li SC, Li Z. The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. Stem Cells Int. 2018 Apr 3;2018:1540148. doi: 10.1155/2018/1540148. eCollection 2018. PMID: 29765406. Free PMC Article </div> <div class="profile-section-item"> Li SC*(* corresponding author), Tachiki LM, Kabeer MH, Dethlefs BA, Anthony MJ, Loudon WG. <br>Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor. <br>Cancer Cell Int. 2014 Nov 12;14(1):115. doi: 10.1186/s12935-014-0115-7. eCollection 2014. PMID: 25411563 <br> <br> <br>Jia KT, Wu YY, Liu ZY, Mi S, Zheng YW, He J, Weng SP, Li SC, He JG, Guo CJ (2013). Mandarin fish caveolin-1 interaction with major capsid protein of infectious spleen and kidney necrosis virus and its role in early stages of infection. J Virol. 2013 Jan 2. [Epub ahead of print] Published ahead of print 2 January 2013, doi: 10.1128/?JVI.00552-12; JVI.00552-12. <br> <br>Loudon WG, Li S *(* corresponding author), Dethlefs B. (2012). Organotypic brain slice matrix. CIP (continuation in part) filed to the USPTO (US Patent and Trademarks Office). <br> <br>Li SC *(* corresponding author), Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. (2012) Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 2012(1):41. [Epub ahead of print]. PMID: 22995409. [PubMed] (Most-accessed: 2181 access) <br> <br>Li SC *(* corresponding author), Loudon WG (2012) The Genome Doctor, a Whole-Genome Sequencing Approach to Cancer. Oncology News (United Kingdom of British) Vol.7, issue 2, page 51-53 http://www.oncologynews.biz/pdf/13%20MJ12%20web/ONMJ12%20web.pdf#page=23 <br> <br>Li SC *(* corresponding author), Yin HZ, Loudon WG, Weiss JH (2012). Cultivating Stem Cells for Treating Amyotrophic Lateral Sclerosis. World Journal of Stem Cells (in press) <br> <br>Loudon WG, Li S *(* corresponding author), Dethlefs B. (2012) USPTO issued patent number: 8,198,083. Organotypic slices of the central nervous system. <br> <br>Li SC *(* corresponding author), Lee KL, Luo J, Zhong JF, Loudon WG. (On the Cover -- http://www.wjgnet.com/1948-0210/index.htm) -- Convergence of normal stem cell and cancer stem cell developmental stage: Implication for differential therapies. World J Stem Cells 2011; 3(9): -000 Available from: URL: http://www.wjgnet.com/1948-0210/full/v3/i9/83.htm, DOI: http://dx.doi.org/10.4252/wjsc.v3.i9.83; http://www.wjgnet.com/1948-0210/news_20110927114034.htm Published online: September 26, 2011. ISSN 1948-0210 (online) <br> <br>Li SC *(* corresponding author), Lee KL, Luo J (2012). Control dominating subclones for managing cancer progression and post-treatment recurrence by subclonal switchboard signal: Implication for new therapies. Stem Cells Dev.. 2012 Mar 1;21(4):503-6. doi: 10.1089/scd.2011.0267. Epub 2011 Nov 2. <br> <br>Li SC * (*corresponding author, primary), Jin Y, Loudon WG, Song Y, Ma Z, Weiner LP, Zhong JF. From the Cover: Increase developmental plasticity of human keratinocytes with gene suppression. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12793-8. Epub 2011 Jul 18. PubMed PMID: 21768375; PubMed Central PMCID: PMC3150912. (Comment on Cover and in Research Highlights) <br> <br>Li SC* (* corresponding author), Acevedo J, Schwartz PH, Wang L, Jiang H, Luo J, Pestell RG, Loudon WG, Chang AC. Mechanisms for Progenitor Cell-mediated Repair for Ischemic Heart Injury. Curr Stem Cell Res Ther. 2011 Apr 5. [Epub ahead of print] PubMed PMID: 21466480. <br> <br>Li SC* (*corresponding author), Tachiki L, Luo J, Dethlefs BA, Chen Z, Loudon WG (2010). A biological global positioning system: considerations for tracking stem cell behaviors in the whole body. Stem Cell Reviews and Reports, 6 (2): 317-333. (DOI: 10.1007/s12015-010-9130-9) Thomas Reuters Impact Factor Index 6.774 (2010). (Feature story: Commented by Jeffrey M. Perkel, Ph.D., BioTechniques Focus: Translational Tools – Special News Feature “What lies beneath: In vivo stem cell imaging,” BioTechniques 50: 223-227 (April 2011) doi 10.2144/000113647) <br> <br>Li SC * (* corresponding author), Han YP, Dethlefs BA, Loudon WG. Therapeutic window, a critical developmental stage for stem cell therapies. Curr Stem Cell Res Ther. 2010 Dec 1; 5(4):297-3. Review. PubMed PMID: 20528752. <br> <br>Hirschberg H, Baek S, Kwon YJ, Sun C, Li SC and Madsen S. ET-16. Macrophage-based nanoparticle delivery into brain tumors: bypassing the blood-brain barrier. Neuro-Oncology (2010) 12 (suppl 4): iv86-iv99. doi: 10.1093/neuonc/noq116.s13. Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2010. <br> <br>Li SC * (* corresponding author), Zhong JF. Twisting immune responses for allogeneic stem cell therapy. World Journal of Stem Cells. 2009 Dec 31;1(1):30-35. PubMed PMID: 20975985; PubMed Central PMCID: PMC2958105. <br> <br>Li SC * (* corresponding author), Wang L, Jiang H, Acevedo J, Chang AC, Loudon WG. Stem cell engineering for treatment of heart diseases: potentials and challenges. Cell Biol Int. 2009 Mar;33(3):255-67. Epub 2008 Dec 3. Review. PubMed PMID: 19084605. <br> <br>Li SC * (* corresponding author), Loudon WG. A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors. Cancer Cell Int. 2008 May 22;8:9. PubMed PMID: 18498656; PubMed Central PMCID: PMC2474582. <br> <br>Tran N, Li S (2008). Differential proteomic panning analysis of protein from serum and cultured stem cells: An alternative to mass spectrometric methods. The FASEB Journal. 2008; 22:lb248) © 2008 FASEB <br> <br>Su Q, Li S* (*corresponding author), (2008). Small activating mRNA (samRNA): A hypothesis for a specific positive feedback regulation of gene expression. Bioscience Hypotheses Vol 1/1 pp 44-47. DOI information: 10.1016/j.bihy.2008.01.007. <br> <br>Li SC * (* corresponding author), Loudon WG (2008). Stem Cell Therapy for Paediatric Malignant Brain Tumours: The Silver Bullet? Oncology News (United Kingdom of British), 2008 June/July, Volume 3 (1): page 10-15. http://www.oncologynews.biz/pdf/jun_jul_08/ONJJ08_stemcell.pdf <br> <br>Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG. Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7438-43. Epub 2007 Apr 25. PubMed PMID: 17460049; PubMed Central PMCID: PMC1863437. <br> <br>Popov VM, Wang C, Shirley LA, Rosenberg A, Li S, Nevalainen M, Fu M, Pestell RG. The functional significance of nuclear receptor acetylation. Steroids. 2007 Feb;72(2):221-30. Epub 2007 Feb 7. Review. PubMed PMID: 17291555; PubMed Central PMCID: PMC2694494. <br> <br>M. Powell, S. Li, M. Lisanti, M. Nevalainen, C. Wang and R. Pestell. Androgen receptor epigenetic modification and acetylation regulate prostate cellular growth. Chapter – Bern eds. Signaling Networks and Epigenetics in Prostate Cancer, Elsevier 2007. DOI: 10.1007/978-1-60327-079-3. ISBN 978-1-58829-741-9 (Print), 978-1-60327-079-3. Pages 147-161. <br> <br>Li S * (* corresponding author), Kirov I, Klassen H, and Schwartz (2006). Characterization of Human Stem Cells Using Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Loring, J, Wesselschmidt, R., and Schwartz, P., Eds., Human Stem Cell Manual: A Laboratory Guide, Elsevier, 2006. <br> <br>Wang H, Haas M, Liang M, Cai T, Tian J, Li S, Xie Z. Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase. J Biol Chem. 2004 Apr 23;279(17):17250-9. Epub 2004 Feb 12. PubMed PMID: 14963033. <br> <br>Zhang L*, Lin WJ*, Li S * (* equal contribution), Aoki KR. Complete DNA sequences of the botulinum neurotoxin complex of Clostridium botulinum type A-Hall (Allergan) strain. Gene. 2003 Oct 2;315:21-32. Erratum in: Gene. 2003 Dec 11;322: 187. PubMed PMID: 14557061. <br> <br>Volonte D, Galbiati F, Li S, Nishiyama K, Okamoto T, Lisanti MP. Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. J Biol Chem. 1999 Apr 30;274(18):12702-9. PubMed PMID: 10212252. <br> <br>Li S, Galbiati F, Volonte D, Sargiacomo M, Engelman JA, Das K, Scherer PE, Lisanti MP. Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes. FEBS Lett. 1998 Aug 28;434(1-2):127-34. PubMed PMID: 9738464. <br> <br>Li S, Lisanti MP, and Puszkin S (1998). Purification and molecular characterization of NP185, a neuron-specific and synapse-enriched clathrin assembly polypeptide. Bioquimica Y Patologia Clinica (Official Journal edition by Southern American Society on Biochemistry). 62(1): 5-17. <br> <br>García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem. 1997 Oct 10;272(41):25437-40. PubMed PMID: 9325253. <br> <br>Puertollano R, Li S, Lisanti MP, Alonso MA. Recombinant expression of the MAL proteolipid, a component of glycolipid-enriched membrane microdomains, induces the formation of vesicular structures in insect cells. J Biol Chem. 1997 Jul 18;272(29):18311-5. PubMed PMID: 9218471. <br> <br>Couet J, Li S, Okamoto T, Scherer PE, Lisanti MP. Molecular and cellular biology of caveolae paradoxes and plasticities. Trends Cardiovasc Med. 1997 May;7(4):103-10. PubMed PMID: 21235872. <br> <br>Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. 1997 Mar 7;272(10):6525-33. PubMed PMID: 9045678. <br> <br>Song KS, Tang Z, Li S, Lisanti MP. Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions. J Biol Chem. 1997 Feb 14;272(7):4398-403. PubMed PMID: 9020162. <br> <br>Song KS, Li Shengwen, Okamoto T, Quilliam LA, Sargiacomo M, Lisanti MP. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem. 1996 Apr 19;271(16):9690-7. PubMed PMID: 8621645. <br> <br>Li S, Couet J, Lisanti MP. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 1996 Nov 15;271(46):29182-90. PubMed PMID: 8910575. <br> <br>Li S, Song KS, Koh SS, Kikuchi A, Lisanti MP. Baculovirus-based expression of mammalian caveolin in Sf21 insect cells. A model system for the biochemical and morphological study of caveolae biogenesis. J Biol Chem. 1996 Nov 8;271(45):28647-54. PubMed PMID: 8910498. <br> <br>Song KS, Scherer PE, Tang Z, Okamoto T, Li S, Chafel M, Chu C, Kohtz DS, Lisanti MP. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem. 1996 Jun 21;271(25):15160-5. PubMed PMID: 8663016. <br> <br>Li S, Seitz R, Lisanti MP. Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo. J Biol Chem. 1996 Feb 16;271(7):3863-8. PubMed PMID: 8632005. <br> <br>Li S, Song KS, Lisanti MP. Expression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes. J Biol Chem. 1996 Jan 5;271(1):568-73. PubMed PMID: 8550621. <br> <br>Lisanti MP, Li S, Tang ZL, Song KS, Kubler E and Scherer PE (1996). Caveolin, an integral membrane protein of caveolae membranes in vivo: Implications for signal transduction. In "?-2 Adrenergic Receptors: Structure, function and therapeutic implications” Edited by Stephen M. Lanier and Lee E. Limbird; pp63-76. Harwood Academic Publishers, 1997. (ISBN 90-5702-019-X), (Cited in 35 papers). <br> <br>Li S, Okamoto T, Chun M, Sargiacomo M, Casanova JE, Hansen SH, Nishimoto I, Lisanti MP. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem. 1995 Jun 30;270(26):15693-701. PubMed PMID: 7797570. <br> <br>Perry DG, Li S, Hanson V, Puszkin S. Neuromuscular junctions contain NP185: the multifunctional protein is located at the presynaptic site. J Neurosci Res. 1992 Nov;33(3):408-17. PubMed PMID: 1469744. <br> <br>Puszkin S, Perry D, Li S, Hanson V. Neuronal protein NP185 is developmentally regulated, initially expressed during synaptogenesis, and localized in synaptic terminals. Mol Neurobiol. 1992 Summer-Fall; 6(2-3):253-83. Review. PubMed PMID: 1476676. <br> <br>Patents issued by USPTO: <br>Patent Reference Numbers: <br>PAT. NO., Title <br>(1) 8,273,865, Multivalent clostridial toxins <br>(2)8,273,358, Activatable clostridial toxins <br>(3)8,198,083, Organotypic slices of the central nervous system <br>(4)8,128,940, Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems <br>(5)8,071,110, Activatable clostridial toxins <br>(6)8,052,979, Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells <br>(7)8,021,859, Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells <br>(8) 7,998,489, Degradable clostridial toxins <br>(9)7,993,656, Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells <br>(10)7,897,157, Activatable clostridial toxins <br>(11)7,892,565, Degradable clostridial toxins <br>(12)7,825,233, Optimizing expression of active Botulinum Toxin type E <br>(13)7,811,584, Multivalent clostridial toxins <br>(14)7,749,514 Activatable clostridial toxins <br>(15)7,740,868, Activatable clostridial toxins <br>(16)7,172,764, Rescue agents for treating botulinum toxin intoxications <br>(17)6,991,789, Methods of modulating intracellular degradation rates of toxins </div> <div class="profile-section-item"> Li SC (corresponding), Kabeer MH. Spatiotemporal switching signals for cancer stem cell activation in pediatric origins of adulthood cancer: Towards a watch-and-wait lifetime strategy for cancer treatment. World J. Stem Cells. 2018;10(2):15-22. doi: 10.4252/wjsc.v10.i2.15. PMID: 29531638 <br> <br>Zeng Y, Gao L, Luo X, Chen Y, Kabeer MH, Chen X, Stucky A, Loudon WG, Li SC (corresponding), Zhang X, Zhong JF. Microfluidic enrichment of plasma cells improves treatment of multiple myeloma. Molecular Oncology 2018. doi: 10.1002/1878-0261.12201. PMID: 29638042. Wiley, John Wiley & Sons, Inc. <br> <br>Li SC (corresponding), Vu LT, Luo JJ, Zhong JF, Li Z, Dethlefs BA, Loudon WG, Kabeer MH.Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a "Watch-and-Wait" Approach to Cancer. Curr Stem Cell Res Ther. 2017;12(6):455-470. doi: 10.2174/1574888X12666170307105941. PMID: 28270089 . PMCID: PMC5587377. Bentham Science Publisher. <br> <br>Chen X, Wen Q, Stucky A, Zeng Y, Gao S, Loudon WG, Ho HW, Kabeer MH, Li SC (corresponding), Zhang X, Zhong JF. Relapse pathway of glioblastoma revealed by single-cell molecular analysis. Carcinogenesis. 2018. doi: 10.1093/carcin/bgy052. PMID: 29718126. Oxford Academic. <br> <br>Li SC*(*corresponding author), Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. (2012) Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 2012(1):41. (Most-accessed: 7895 access, as of April 04, 2018) <br> <br>Vu LT, Keschrum V, Zhang X, Zhong JF, Kabeer MH, Loudon WG, Li SC. Tissue elasticity regulated tumor gene expression: Implication for diagnostic biomarkers of primitive neuroectodermal tumor. PLoS One. 2015 Mar 16;10(3):e0120336. (First evidence for tissue-elasticity-regulated tumor progression via microRNA) <br>(1514 accesses) <br> <br>(1Zhongping Chen, PhD; 1,2,5Shengwen Calvin Li, PhD; 3John F. Zhong, PhD; 5Hong Zhen Yin, MD; 4, 5Steven S. Schreiber, MD; 4Norman N. Ge, MD; 2William G. Loudon, MD-PhD; 5John H. Weiss, MD-PhD). Abstract # MHSRS-17-0926 - TBI - Frontline/Prehospital Management - In vivo MPM imaging technology and single-cell transcriptomes for evaluating personalized treatment of traumatic brain injury.” 2017 MHSRS (The US Department of Defense - Military Health System Research Symposium). <br> <br>Vu LT, Keschrumrus V, Zhang X, Zhong JF, Su Q, Kabeer MH, Loudon WG, Li SC*(* corresponding author).Correction: Tissue elasticity regulated tumor gene expression: implication for diagnostic biomarkers of primitive neuroectodermal tumor. PLoS One. 2015 May 19;10(5):e0128504. doi: 10.1371/journal.pone.0128504. eCollection 2015. No abstract available. PMID:25992612 <br> <br>Yuan JM, He BL, Yang LY, Guo CJ, Weng SP, Li SC, He JG. <br>Interaction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish. <br>J Virol. 2015 Jan;89(1):763-75. doi: 10.1128/JVI.01955-14. Epub 2014 Oct 29.PMID: 25355883 <br> <br>Li SC*(* corresponding author), Kabeer MH, Vu LT, Keschrumrus V, Yin HZ, Dethlefs BA, Zhong JF, Weiss JH, Loudon WG. Training stem cells for treatment of malignant brain tumors. World J Stem Cells 2014 September 26; 6(4): 432-440. (Provided evidence to show that engineered tissue brain environment cultivate neural differentiation of stem cells) <br> <br>SC*(* corresponding author), Tachiki LM, Kabeer MH, Dethlefs BA, Anthony MJ, Loudon WG. <br>Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor. Cancer Cell Int. 2014 Nov 12;14(1):115. doi: 10.1186/s12935-014-0115-7. eCollection 2014. PMID: 25411563 <br> <br>Li SC *(* corresponding author) and Kabeer MH (2013), Designer Immunotherapy Specific for Cancer. J Cell Sci Ther 2013, 4:1. http://dx.doi.org/10.4172/2157-7013.1000e116 <br> <br>Li SC*(* corresponding author), Yin HZ, Loudon WG, Weiss JH. Cultivating stem cells for treating amyotrophic lateral sclerosis. World J Stem Cells. 2012 Dec 26;4(12):117-9. doi: 10.4252/wjsc.v4.i12.117. PMID: 23516096 [PubMed] <br> <br>Jia KT, Wu YY, Liu ZY, Mi S, Zheng YW, He J, Weng SP, Li SC, He JG, Guo CJ (2013). Mandarin fish caveolin-1 interaction with major capsid protein of infectious spleen and kidney necrosis virus and its role in early stages of infection. J Virol. 2013 Jan 2. [Epub ahead of print] Published ahead of print 2 January 2013, doi: 10.1128/?JVI.00552-12; JVI.00552-12. <br> <br> <br>Li SC *(* corresponding author), Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. (2012) Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 2012(1):41. [Epub ahead of print]. PMID: 22995409. [PubMed] (Most-accessed: 2457access) <br> <br>Li SC *(* corresponding author), Loudon WG (2012) The Genome Doctor, a Whole-Genome Sequencing Approach to Cancer. Oncology News (United Kingdom of British) Vol.7, issue 2, page 51-53 http://www.oncologynews.biz/pdf/13%20MJ12%20web/ONMJ12%20web.pdf#page=23 <br> <br>Li SC *(* corresponding author), Yin HZ, Loudon WG, Weiss JH (2012). Cultivating Stem Cells for Treating Amyotrophic Lateral Sclerosis. World J Stem Cells (in press) <br> <br>Loudon WG, Li S *(* corresponding author), Dethlefs B (2012) USPTO issued patent number: 8,198,083. Organotypic slices of the central nervous system. <br> <br> <br>Li SC *(* corresponding author), Lee KL, Luo J, Zhong JF, Loudon WG. (On the Cover -- http://www.wjgnet.com/1948-0210/index.htm) -- Convergence of normal stem cell and cancer stem cell developmental stage: Implication for differential therapies. World J Stem Cells 2011; 3(9): -000 Available from: URL: http://www.wjgnet.com/1948-0210/full/v3/i9/83.htm, DOI: http://dx.doi.org/10.4252/wjsc.v3.i9.83; http://www.wjgnet.com/1948-0210/news_20110927114034.htm Published online: September 26, 2011. ISSN 1948-0210 (online) <br> <br>Li SC *(* corresponding author), Lee KL, Luo J (2012). Control dominating subclones for managing cancer progression and post-treatment recurrence by subclonal switchboard signal: Implication for new therapies. Stem Cells Dev.. 2012 Mar 1;21(4):503-6. doi: 10.1089/scd.2011.0267. Epub 2011 Nov 2. <br> <br>Li SC* (* corresponding author), Acevedo J, Schwartz PH, Wang L, Jiang H, Luo J, Pestell RG, Loudon WG, Chang AC. Mechanisms for Progenitor Cell-mediated Repair for Ischemic Heart Injury. Curr Stem Cell Res Ther. 2011 Apr 5. [Epub ahead of print] PubMed PMID: 21466480. </div> <div class="profile-section-item"> Li SC*(*Corresponding author), Yin HZ, Loudon WG, Weiss JH. <br>Cultivating stem cells for treating amyotrophic lateral sclerosis. <br>World J Stem Cells. 2012 Dec 26;4(12):117-9. doi: 10.4252/wjsc.v4.i12.117. <br>PMID: 23516096 [PubMed] Free PMC Article </div> <div class="profile-section-item"> CRIF1 as a potential target to improve the radiosensitivity of osteosarcoma. <br>Ran Q, Jin F, Xiang Y, Xiang L, Wang Q, Li F, Chen L, Zhang Y, Wu C, Zhou L, Xiao Y, Chen L, Wu J, Zhong JF, Li SC, Li Z. <br>Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20511-20516. doi: 10.1073/pnas.1906578116. Epub 2019 Sep 23. <br>PMID: 31548420 </div> <div class="profile-section-item"> Wu J, Zhang W, Ran Q, Xiang Y, Zhong JF, Li SC, Li Z. The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. Stem Cells Int. 2018 Apr 3;2018:1540148. doi: 10.1155/2018/1540148. eCollection 2018. Review. PMID: 29765406 Free PMC Article </div> <div class="profile-section-item"> ect <br>Xiang LX, Ran Q, Chen L, Xiang Y, Li FJ, Zhang XM, Xiao YN, Zou LY, Zhong JF, Li SC, Li ZJ. CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor ?B ligand after radiation. World J Stem Cells. 2020 Mar 26;12(3):222-240. doi: 10.4252/wjsc.v12.i3.222. PubMed PMID: 32266053; PubMed Central PMCID: PMC7118287. </div> <div class="profile-section-item"> Wang J, Li X, Zhou J, Qiu D, Zhang M, Sun L, Li SC. Long-term survival with anlotinib as a front-line treatment in an elderly NSCLC patient: A case report. Front Oncol. 2023;13:1043244. doi: 10.3389/fonc.2023.1043244. eCollection 2023. PubMed PMID: 37091182; PubMed Central PMCID: PMC10117841. <br> <br>select <br>Zhang J, Su Q, Li SC. Qigong Exercise Balances Oxygen Supply and Acid-Base to Modulate Hypoxia: A Perspective Platform toward Preemptive Health & Medicine. Med Sci (Basel). 2023 Feb 28;11(1). doi: 10.3390/medsci11010021. PubMed PMID: 36976529; PubMed Central PMCID: PMC10057714. <br> <br>select <br>Sun L, Li X, Tu L, Stucky A, Huang C, Chen X, Cai J, Li SC. RNA-Sequencing Combined With Genome-Wide Allele-Specific Expression Patterning Identifies ZNF44 Variants as a Potential New Driver Gene for Pediatric Neuroblastoma. Cancer Control. 2023 Jan-Dec;30:10732748231175017. doi: 10.1177/10732748231175017. PubMed PMID: 37161925; PubMed Central PMCID: PMC10185978. <br> <br>select <br>Li SC, Kabeer MH. Caveolae-Mediated Extracellular Vesicle (CMEV) Signaling of Polyvalent Polysaccharide Vaccination: A Host-Pathogen Interface Hypothesis. Pharmaceutics. 2022 Nov 30;14(12). doi: 10.3390/pharmaceutics14122653. Review. PubMed PMID: 36559147; PubMed Central PMCID: PMC9784826. <br> <br>select <br>Li SC, He J. A generalizable and tunable engineered ecosystem provides a clear route to prosperity and well-being to harness the world’s aquatic “blue” food systems to help end hunger: A perspective. Front. Food. Sci. Technol.. 2022 September. doi: 10.3389/frfst.2022.886808. <br> <br>select <br>Li SC, He JG. A generalizable and tunable engineered ecosystem provides a clear route to prosperity and well-being to harness the world's aquatic "blue" food systems to help end hunger: A perspective. Front Food Sci Technol. 2022;2. doi: 10.3389/frfst.2022.886808. Epub 2022 Sep 21. PubMed PMID: 36312446; PubMed Central PMCID: PMC9617584. <br> <br>select <br>Xiang Y, Ran Q, Wu C, Zhou L, Zhang , Li J, Xiang L, Xiao Y, Chen L, Chen , Chen X, Stucky , Li SC, Zhong JF, Li,,Zhongjun ,, Cai K. Single-cell transcriptomics uncovers the impacts of titanium dioxide nanoparticles on human bone marrow stromal cells. Chemical Engineering Journal. 2022 July; 440:135814. doi: 10.1016/j.cej.2022.135814. <br> <br>select <br>Li X, Wang X, Huang R, Stucky A, Chen X, Sun L, Wen Q, Zeng Y, Fletcher H, Wang C, Xu Y, Cao H, Sun F, Li SC, Zhang X, Zhong JF. The Machine-Learning-Mediated Interface of Microbiome and Genetic Risk Stratification in Neuroblastoma Reveals Molecular Pathways Related to Patient Survival. Cancers (Basel). 2022 Jun 10;14(12). doi: 10.3390/cancers14122874. PubMed PMID: 35740540; PubMed Central PMCID: PMC9220810. <br> <br>select <br>Stucky A, Gao L, Li SC, Tu L, Luo J, Huang X, Chen X, Li X, Park TH, Cai J, Kabeer MH, Plant AS, Sun L, Zhang X, Zhong JF. Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes. Front Cell Dev Biol. 2022;10:699144. doi: 10.3389/fcell.2022.699144. eCollection 2022. PubMed PMID: 35356283; PubMed Central PMCID: PMC8959432. <br> <br>select <br>Li X, Sun L, Stucky A, Tu L, Cai J, Chen X, Wu Z, Jiang X, Li SC. Reply to Schramm, L. Comment on "Li et al. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics 2021, 11, 2364". Diagnostics (Basel). 2022 Mar 2;12(3). doi: 10.3390/diagnostics12030617. PubMed PMID: 35328170; PubMed Central PMCID: PMC8947584. <br> <br>select <br>Zhang X, Hou L, Li F, Zhang W, Wu C, Xiang L, Li J, Zhou L, Wang X, Xiang Y, Xiao Y, Li SC, Chen L, Ran Q, Li Z. Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury. Theranostics. 2022;12(4):1621-1638. doi: 10.7150/thno.64963. eCollection 2022. PubMed PMID: 35198061; PubMed Central PMCID: PMC8825582. <br> <br>select <br>Li X, Sun L, Stucky A, Tu L, Cai J, Chen X, Wu Z, Jiang X, Li SC. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics (Basel). 2021 Dec 15;11(12). doi: 10.3390/diagnostics11122364. PubMed PMID: 34943600; PubMed Central PMCID: PMC8700758. <br> <br>select <br>Wang M, Chen Y, Zhao Z, Weng S, Yang J, Liu S, Liu C, Yuan F, Ai B, Zhang H, Zhang M, Lu L, Yuan K, Yu Z, Mo B, Liu X, Gai C, Li Y, Lu R, Zhong Z, Zheng L, Feng G, Li SC, He J. A convenient polyculture system that controls a shrimp viral disease with a high transmission rate. Commun Biol. 2021 Nov 11;4(1):1276. doi: 10.1038/s42003-021-02800-z. PubMed PMID: 34764419; PubMed Central PMCID: PMC8585955. <br> <br>select <br>Sun M, Xue X, Li L, Xu D, Li S, Li SC, Su Q. Ectosome biogenesis and release processes observed by using live-cell dynamic imaging in mammalian glial cells. Quant Imaging Med Surg. 2021 Nov;11(11):4604-4616. doi: 10.21037/qims-20-1015. PubMed PMID: 34737927; PubMed Central PMCID: PMC8511719. <br> <br>select <br>Li F, Zhang R, Hu C, Ran Q, Xiang Y, Xiang L, Chen L, Yang Y, Li SC, Zhang G, Li Z. Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rß1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells. Front Cell Dev Biol. 2021;9:729293. doi: 10.3389/fcell.2021.729293. eCollection 2021. PubMed PMID: 34540843; PubMed Central PMCID: PMC8446663. <br> <br>select <br>Li SC. Publons Academy Peer-review Verified Record as of April 23, 2021: Peer-review Verified Record: 202 manuscripts for Journals. Peer-review Verified Record for editor tasks: 14 Journal manuscripts. Publons Academy Peer-review Verified Record. 2021 April. doi: 10.13140/RG.2.2.28881.45929. <br> <br>select <br>Zhang XM, Chen DG, Li SC, Zhu B, Li ZJ. Embryonic Origin and Subclonal Evolution of Tumor-Associated Macrophages Imply Preventive Care for Cancer. Cells. 2021 Apr 14;10(4). doi: 10.3390/cells10040903. Review. PubMed PMID: 33919979; PubMed Central PMCID: PMC8071014. <br> <br>select <br>Wang X, Zhou Y, Liu L, Ma J, Wu H, Zhao L, Chen , Li SC, Ran Q, Li Z. Coronavirus disease 2019 (COVID-19): diagnosis and prognosis. Blood Genom.. 2021 March; 4(2):96-107. <br> <br>select <br>Zeng Y, Gao L, Luo X, Chen Y, Kabeer MH, Chen X, Stucky A, Loudon WG, Li SC, Zhang X, Zhong JF. Corrigendum to: Microfluidic enrichment of plasma cells improves treatment of multiple myeloma. Mol Oncol. 2021 Jan;15(1):317. doi: 10.1002/1878-0261.12874. PubMed PMID: 33398937; PubMed Central PMCID: PMC7782077. <br> <br>select <br>Stucky A, Gao L, Sun L, Li SC, Chen X, Park TH, Cai J, Kabeer MH, Zhang X, Sinha UK, Zhong JF. Evidence for AJUBA-catenin-CDH4-linked differentiation resistance of mesenchymal stem cells implies tumorigenesis and progression of head and neck squamous cell carcinoma: a single-cell transcriptome approach. Blood Genom. 2021;5(1):29-39. doi: 10.46701/BG.2021012021106. PubMed PMID: 34368804; PubMed Central PMCID: PMC8346230. <br> <br>select <br>Chen Y, Yang Y, Wang M, Zhao Z, Weng,,S.,, Lu,,L.,, Liu S, Liu C, Yuan F, Ai B, Zhang H, Zhang M, Yuan K, Yu J, Mo B, Zhong Z, Zheng L, Feng G, Li SC, He J. Effective control of a viral disease with a high transmission rate through selective predation. bioRxiv.. 2020 October. doi: 10.1101/2020.09.24.311563. <br> <br>select <br>Lee LX, Li SC. Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective. World J Stem Cells. 2020 Aug 26;12(8):706-720. doi: 10.4252/wjsc.v12.i8.706. Review. PubMed PMID: 32952853; PubMed Central PMCID: PMC7477658. <br> <br>select <br>Li SC, Kabeer MH. Autologous Splenocyte Reinfusion Improves Antibody-Mediated Immune Response to the 23-Valent Pneumococcal Polysaccharide-Based Vaccine in Splenectomized Mice. Biomolecules. 2020 May 1;10(5). doi: 10.3390/biom10050704. PubMed PMID: 32369978; PubMed Central PMCID: PMC7277809. <br> <br>select <br>Xiang LX, Ran Q, Chen L, Xiang Y, Li FJ, Zhang XM, Xiao YN, Zou LY, Zhong JF, Li SC, Li ZJ. CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor ?B ligand after radiation. World J Stem Cells. 2020 Mar 26;12(3):222-240. doi: 10.4252/wjsc.v12.i3.222. PubMed PMID: 32266053; PubMed Central PMCID: PMC7118287. <br> <br>select <br>Li SC, Sparks KJ, Sender LS. Implementation and Validation of the Roche Light Cycler 480 96-Well Plate Platform as a Real-Time PCR Assay for the Quantitative Detection of Cytomegalovirus (CMV) in Clinical Specimens Using the Luminex MultiCode ASRs System. Med. Sci. 2020, 8(1), 14; https://doi.org/10.3390/medsci8010014. 2020 March; 8:14. doi: 10.3390/medsci8010014. <br> <br>select <br>Li SC, Sparks KJ, Sender LS. Implementation and Validation of the Roche Light Cycler 480 96-Well Plate Platform as a Real-Time PCR Assay for the Quantitative Detection of Cytomegalovirus (CMV) in Clinical Specimens Using the Luminex MultiCode ASRs System. Med Sci (Basel). 2020 Mar 11;8(1). doi: 10.3390/medsci8010014. PubMed PMID: 32168800; PubMed Central PMCID: PMC7151591. <br> <br>select <br>Wang X, Zhou Y, Liu L, Ma J, Wu H, Zhao L, Chen W, Li SC, Ran Q, Li Z. Coronavirus disease 2019 (COVID-19): diagnosis and prognosis. Blood Genom. 2020;4(2):96-107. doi: 10.46701/BG.2020022020120. PubMed PMID: 33768219; PubMed Central PMCID: PMC7990318. <br> <br>select <br>Zhang J, Su Q, Loudon WG, Lee KL, Luo J, Dethlefs BA, Li SC. Breathing Signature as Vitality Score Index Created by Exercises of Qigong: Implications of Artificial Intelligence Tools Used in Traditional Chinese Medicine. J Funct Morphol Kinesiol. 2019 Dec;4(4). doi: 10.3390/jfmk4040071. Epub 2019 Dec 3. PubMed PMID: 31853512; PubMed Central PMCID: PMC6919646. </div> </div> <div id="professional-societies" class="profile-section"> <strong>Professional Societies</strong> <br> <div class="profile-section-item"> American Society for Cell Biolgy </div> <div class="profile-section-item"> International Society for Stem Cell Research </div> <div class="profile-section-item"> Association for Clinical and Translational Science </div> <div class="profile-section-item"> The Royal Society of Medicine, The United Kingdom (2018-) </div> <div class="profile-section-item"> American Society for Investigative Pathology (2008-) </div> <div class="profile-section-item"> Society for Neuroscience (2003-) </div> <div class="profile-section-item"> American Society for Neurochemistry (1993-) </div> <div class="profile-section-item"> American Association for the Advancement of Science (1993-) </div> <div class="profile-section-item"> The Royal Society of Biology, The United Kingdom (2021.July) </div> </div> <div id="other-experience" class="profile-section"> <strong>Other Experience</strong> <br> <div class="profile-section-item"> Editorial Board Member<br>American Society for Investigative Pathology, American Journal of Pathology (Elsevier Publishing) 2008—2016 <br> </div> <div class="profile-section-item"> Editorial Board Member, Section Editor<br>Current Stem Cell Research & Therapy (Bentham Science Publishers) 2016—now <br> </div> <div class="profile-section-item"> Elected overseas fellow<br>The Royal Society of Medicine, The United Kingdom of Great British 2018—now <br> </div> <div class="profile-section-item"> Editorial Board Medmber<br>World Journal of Stem Cells (Baishideng Publishing Group,Pasadena, CA, USA) 2012—now <br> </div> <div class="profile-section-item"> Editorial Board Member<br>https://www.mdpi.com/journal/medsci/editors (“Medical Sciences” — Journal Editorial Board, MDPI (Basel, Switzerland), Cristina Saez Lopez, PhD, Managing Editor) 2018—now <br> </div> <div class="profile-section-item"> Review Board Member<br>Journal “Cells” by MDPI (Basel, Switzerland), Janet Yan, PhD, Managing Editor 2018—now <br> </div> <div class="profile-section-item"> Editorial Board Member<br>, Quantitative Imaging in Medicine and Surgery (QIMS, Quant Imaging Med Surg, Print ISSN 2223-4292; Online ISSN 2223-4306), Hong Kong 2016—now <br> </div> <div class="profile-section-item"> Editor-in-Chief<br>World Journal of Stem Cells (Baishideng Publishing Group,Pasadena, CA, USA) 2019—now <br> </div> <div class="profile-section-item"> Section Editor, Cancer Control<br>SAGE Publishing, United Kingdom (U.K.) 2021—now <br> </div> <div class="profile-section-item"> Associate Editor, Frontier in Oncology<br>Frontiers Media Inc., Switzerland 2020—now <br> </div> <div class="profile-section-item"> Academic Editor, PLOS ONE<br>Public Library of Science (PLoS), San Francisco, California, United States of America (USA) 2019—now <br> </div> <div class="profile-section-item"> Visiting Scholar<br>University of Southern California 2010 <br> </div> </div> <div class="profile-section"> <div id="profile-link" class="profile-section-item"> <strong>Link to this profile</strong> <br> <a href="https://faculty.uci.edu/profile/?facultyId=5952">https://faculty.uci.edu/profile/?facultyId=5952</a> </div> <div id="profile-last-updated" class="profile-section-item"> <strong>Last updated</strong> <br> 09/30/2023 </div> </div> </div> </div> <div id="footer"> <ul class="footer-links"> <li> <a href="https://uci.edu/copyright/">© 2023 The Regents of the University of California</a> | </li> <li> <a href="https://research.uci.edu/privacy-policy-2/" target="_blank" title="Privacy Policy">Privacy & Legal Notice</a> | </li> <li> <a href="mailto:or-web-support@uci.edu">Email FPS Support</a> </li> </ul> </div> </div> <script src="https://faculty.uci.edu/js/jquery-3.6.0.min.js"></script> <script src="https://faculty.uci.edu/js/header.js"></script> </body> </html>