Apicoplast - Infectious Diseases

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It is derived from a secondary endosymbiosis event and is a non-photosynthetic plastid. This organelle is essential for the survival of these parasites, as it is involved in various critical biosynthetic pathways.</div><div><a href="https://infect.blog/knowledgebase/why-is-the-apicoplast-important-in-infectious-diseases" title="Why is the Apicoplast Important in Infectious Diseases?"><h3>Why is the Apicoplast Important in Infectious Diseases?</h3></a>The apicoplast plays a crucial role in the survival and virulence of certain parasites. It is involved in the biosynthesis of fatty acids, isoprenoids, and heme. These metabolic processes are vital for the parasite, making the apicoplast a potential target for novel <a href="https://infect.blog/about/index/antimicrobial-drugs" title="antimicrobial drugs" target="_blank">antimicrobial drugs</a>. Disrupting the function of the apicoplast can lead to the death of the parasite, thereby treating the infection.</div><div><a href="https://infect.blog/knowledgebase/how-can-we-target-the-apicoplast-for-treatment" title="How Can We Target the Apicoplast for Treatment?"><h3>How Can We Target the Apicoplast for Treatment?</h3></a>Given its essential functions, the apicoplast has been studied extensively as a potential drug target. Several <a href="https://infect.blog/about/index/antimalarial-drugs" title="antimalarial drugs" target="_blank">antimalarial drugs</a>, such as doxycycline and clindamycin, target the apicoplast's protein synthesis machinery. These drugs can inhibit the replication of the parasite by disrupting the function of the apicoplast. Additionally, new drugs are being developed to target other pathways within the apicoplast, such as those involved in <a href="https://infect.blog/about/index/fatty-acid-biosynthesis" title="fatty acid biosynthesis" target="_blank">fatty acid biosynthesis</a> and <a href="https://infect.blog/about/index/isoprenoid-biosynthesis" title="isoprenoid biosynthesis" target="_blank">isoprenoid biosynthesis</a>.</div><div><a href="https://infect.blog/knowledgebase/what-are-the-challenges-in-targeting-the-apicoplast" title="What Are the Challenges in Targeting the Apicoplast?"><h3>What Are the Challenges in Targeting the Apicoplast?</h3></a>One of the main challenges in targeting the apicoplast is the development of drug resistance. Parasites can evolve mechanisms to bypass the need for certain functions of the apicoplast, rendering some drugs ineffective. Moreover, the complex biology of the apicoplast, including its distinct set of genes and metabolic pathways, requires a deep understanding to develop effective drugs. Another challenge is ensuring that drugs can selectively target the apicoplast without affecting similar pathways in the human host, thus minimizing potential side effects.</div><div><a href="https://infect.blog/knowledgebase/what-research-is-being-conducted-on-apicoplasts" title="What Research is Being Conducted on Apicoplasts?"><h3>What Research is Being Conducted on Apicoplasts?</h3></a>Research on apicoplasts is ongoing and multifaceted. Scientists are investigating the <a href="https://infect.blog/about/index/genomic-structure" title="genomic structure" target="_blank">genomic structure</a> and function of the apicoplast to better understand its role in parasite biology. Advances in <a href="https://infect.blog/about/index/genetic-engineering" title="genetic engineering" target="_blank">genetic engineering</a> techniques, such as CRISPR/Cas9, are being used to manipulate the genes of the apicoplast. This helps in identifying new drug targets and understanding the mechanisms of drug resistance. Additionally, high-throughput screening methods are used to identify compounds that can specifically inhibit apicoplast functions.</div><div><h3>Conclusion</h3>The apicoplast is a critical organelle in Apicomplexan parasites and represents a promising target for the development of new treatments for infectious diseases like malaria and toxoplasmosis. While there are challenges in targeting the apicoplast, ongoing research and advancements in technology hold promise for overcoming these obstacles and improving the efficacy of treatments.</div></div> </div> <div id="recent_papers"> <br><hr /><br><h2 class="heading1">Relevant Publications</h2> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38865262" target='_blank' title="A pyruvate transporter in the apicoplast of apicomplexan parasites.">A pyruvate transporter in the apicoplast of apicomplexan parasites.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38821633" target='_blank' title="Protists: Eukaryotic single-celled organisms and the functioning of their organelles.">Protists: Eukaryotic single-celled organisms and the functioning of their organelles.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38338378" target='_blank' title="Drug Repurposing in the Chemotherapy of Infectious Diseases.">Drug Repurposing in the Chemotherapy of Infectious Diseases.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38352445" target='_blank' title="Detailing organelle division and segregation in .">Detailing organelle division and segregation in .</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38393103" target='_blank' title="Identification of and Species in Muscles of Gray Wolf () from Lithuania.">Identification of and Species in Muscles of Gray Wolf () from Lithuania.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39082802" target='_blank' title="CRISPR screens identify genes essential for virulence among proteins of hyperLOPIT-unassigned subcellular localization in .">CRISPR screens identify genes essential for virulence among proteins of hyperLOPIT-unassigned subcellular localization in .</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39241090" target='_blank' title="Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum.">Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38559241" target='_blank' title="The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in .">The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in .</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38255695" target='_blank' title="Anti-Cryptosporidial Drug-Discovery Challenges and Existing Therapeutic Avenues: A \"One-Health\" Concern.">Anti-Cryptosporidial Drug-Discovery Challenges and Existing Therapeutic Avenues: A \"One-Health\" Concern.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38416592" target='_blank' title="Myosin F controls actin organization and dynamics in .">Myosin F controls actin organization and dynamics in .</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38410435" target='_blank' title="Progressive heterogeneity of enlarged and irregularly shaped apicoplasts in persister blood stages after drug treatment.">Progressive heterogeneity of enlarged and irregularly shaped apicoplasts in persister blood stages after drug treatment.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38293033" target='_blank' title="Multiomics analysis reveals MO1 as a distinct species and provides insights into its evolution and virulence.">Multiomics analysis reveals MO1 as a distinct species and provides insights into its evolution and virulence.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38456076" target='_blank' title="Putative molecular markers of resistance to antimalarial drugs in malaria parasites from Ghana.">Putative molecular markers of resistance to antimalarial drugs in malaria parasites from Ghana.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38502570" target='_blank' title="The monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival.">The monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38444020" target='_blank' title="Hepatozoon (Eucoccidiorida: Hepatozoidae) in wild mammals of the Americas: a systematic review.">Hepatozoon (Eucoccidiorida: Hepatozoidae) in wild mammals of the Americas: a systematic review.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38431113" target='_blank' title="Potent hydroxamate-derived compounds arrest endodyogeny of Toxoplasma gondii tachyzoites.">Potent hydroxamate-derived compounds arrest endodyogeny of Toxoplasma gondii tachyzoites.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38666816" target='_blank' title="Inhibitors against DNA Polymerase I Family of Enzymes: Novel Targets and Opportunities.">Inhibitors against DNA Polymerase I Family of Enzymes: Novel Targets and Opportunities.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38651914" target='_blank' title="Gapless assembly of NVSL348.">Gapless assembly of NVSL348.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38821048" target='_blank' title="A new and widespread group of fish apicomplexan parasites.">A new and widespread group of fish apicomplexan parasites.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38765186" target='_blank' title="Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Parasites.">Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Parasites.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> </div> </div> <div id="way2buy_left_banner_1" class="rightads"></div> </div> <div class="col-md-4 mt-50"> <style> .qa-container1 { width: 100%; max-width: 800px; text-align: left; } .qa-item1 { margin: 10px 0; border-bottom: 1px solid #e5e5e5; padding-bottom: 16px; } .qa-item1 a { text-decoration: none; color: #000; font-size: 15px; font-weight: bold; font-weight: 500 !important; } .qa-item1 a:hover { color: #005177; text-decoration: underline; } </style> <div class="fl-wrap1"> <div class="widget-title text-left">Frequently asked queries:</div> <div class="qa-container1"> <div class="qa-item1"> <a 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