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class="content-sidebar-wrap"><main class="content"><article class="post-17502 post type-post status-publish format-standard has-post-thumbnail category-pharmamfg tag-biotech tag-biotech-manufacturing tag-pharma-manufacturing tag-pharmaceutical-manufacturing tag-process-monitoring entry" aria-label="Why use Raman for Process Monitoring?"><header class="entry-header"><h1 class="entry-title">Why use Raman for Process Monitoring?</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/behind-the-bench-staff/" title="Posts by Behind The Bench Staff" rel="author">Behind The Bench Staff</a> </span> <span class="post-info-date"> 01.30.2023 </span> </header><div class="entry-content"><p><span style="font-weight: 400"><img decoding="async" class="alignright wp-image-17506" src="https://www.thermofisher.com/blog/behindthebench/wp-content/uploads/sites/9/2023/01/iStock-481969250_cellculture.jpg" alt="cell culture analysis" width="450" height="300" srcset="https://www.thermofisher.com/blog/behindthebench/wp-content/uploads/sites/9/2023/01/iStock-481969250_cellculture.jpg 724w, https://www.thermofisher.com/blog/behindthebench/wp-content/uploads/sites/9/2023/01/iStock-481969250_cellculture-300x200.jpg 300w, https://www.thermofisher.com/blog/behindthebench/wp-content/uploads/sites/9/2023/01/iStock-481969250_cellculture-96x65.jpg 96w" sizes="(max-width: 450px) 100vw, 450px" />Raman spectroscopy is a highly regarded method that benefits analytical, laboratory and <a href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-pharmaceutical-qa-qc-manufacturing-solutions.html?icid=CAD_blog_LSM_2023Jan">process monitoring applications</a>. Real-time process understanding is just one benefit of using Raman, and it allows users to make timely corrections and increase process efficiency, along with many other advantages. This blog post will look at why Raman is an ideal component for process monitoring.</span></p> <p><span style="font-weight: 400">Raman spectroscopy is a non-invasive analytical technique to obtain information about a molecule’s chemical and structural composition. This method works by directing a laser light source at a sample through which the light is scattered. The light that is scattered at different wavelengths makes up a Raman spectrum that can be used to verify the chemical identity of a sample and even quantify the concentration of a sample. </span></p> <h2><span style="font-weight: 400">How Does Raman Benefit Process Monitoring?</span></h2> <p><span style="font-weight: 400">Process monitoring is used for several reasons. When manufacturers are carrying out operations, monitoring is necessary to ensure the processes are accurate, safe, reliable and result in the desired product. <a href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-pharmaceutical-qa-qc-manufacturing-solutions.html?icid=CAD_blog_LSM_2023Jan">Process monitoring tools</a> are also essential in identifying errors, failures, or potential risks before they become quality issues.</span></p> <p><span style="font-weight: 400">Raman spectroscopy has been crucial to many applications in the pharmaceutical industry for many years because of its main advantages. Using Raman-based process analytical technologies (PAT) for process monitoring, especially in-line, offers key benefits that help improve processes and ensure their safety. Additionally, scientists can be notified immediately of any damages or errors, allowing them to make corrections in real time. </span></p> <p><span style="font-weight: 400">Not only is Raman extremely sensitive to the composition and structure of a molecule, but it also enables the accurate characterization of samples. Raman can be used to analyze samples in optically transparent containers or even in water, all without the need for preparation or contact. </span></p> <p><span style="font-weight: 400">Some of the other benefits include the following: </span></p> <ul> <li style="font-weight: 400"><span style="font-weight: 400">Easy to set up: Saving time and money on additional installation costs</span></li> <li style="font-weight: 400"><span style="font-weight: 400">Non-destructive: Samples need not be damaged, and the risk of contamination is reduced</span></li> <li style="font-weight: 400"><span style="font-weight: 400">No sample preparation: Meaningful time can be spent on other parts of the overall development or production process</span></li> <li style="font-weight: 400"><span style="font-weight: 400">Non-interruptive: Processes need not be stopped nor paused to perform analysis</span></li> <li style="font-weight: 400"><span style="font-weight: 400">Improved process understanding and efficiency</span></li> <li style="font-weight: 400"><span style="font-weight: 400">Suitable for harsh environments, including high temperatures</span></li> </ul> <p><span style="font-weight: 400">For effective and accurate process monitoring, choosing a suitable analyzer is crucial. The right analyzer should enable easy and non-destructive real-time measurements that are precise and prompt. A </span><a href="https://www.thermofisher.com/order/catalog/product/MarqMetrixAIO?icid=CAD_blog_LSM_2023Jan"><span style="font-weight: 400">process analyzer</span></a><span style="font-weight: 400"> should remove the need for lengthy sample preparation methods, reduce contamination risks and ultimately help to improve the speed and efficiency of the process.</span></p> <p>Read about additional technologies on our website for <a href="https://www.thermofisher.com/us/en/home/industrial/manufacturing-processing/improving-pharmaceutical-biotech-manufacturing-processes-production-methods.html?icid=CAD_blog_LSM_2023Jan">Improving Pharmaceutical and Biotech Manufacturing Processes</a></p> <p><em>Author: Dean Stuart</em></p> <p><em>Resources: </em></p> <ul> <li>eBook: <a href="https://www.thermofisher.com/us/en/home/global/forms/industrial/lsm-pharma-biotech-mfg-processes-production-ebook-registration-form.html?icid=CAD_blog_LSM_2023Jan">A Practical Guide to Improving Pharmaceutical and 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