CINXE.COM

<!DOCTYPE html><html lang="en"><head><meta charSet="utf-8"/><meta name="viewport" content="width=device-width"/><script src="https://cmp.osano.com/6olh2SicG0V81Mlk/1f9d883d-3834-40b9-9a96-6f89a1cda98b/osano.js"></script><title>New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma</title><meta name="description" content="This study introduces a novel "all-in-one" strategy combining CD7 chimeric antigen receptor T-cell therapy with haploidentical hematopoietic stem-cell transplantation, showing significant potential to improve survival and reduce toxicities in patients with relapsed or refractory CD7-positive hematologic cancers. "/><meta property="og:url" content="https://www.ajmc.com/view/new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma "/><meta property="og:title" content="New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma"/><meta property="og:image" content="https://cdn.sanity.io/images/0vv8moc6/ajmc/04663c88d2d04992175ced53fda8bb885d2d2ee8-1200x724.jpg?fit=crop&auto=format"/><meta property="og:site_name" content="AJMC"/><meta property="og:description" content="This study introduces a novel "all-in-one" strategy combining CD7 chimeric antigen receptor T-cell therapy with haploidentical hematopoietic stem-cell transplantation, showing significant potential to improve survival and reduce toxicities in patients with relapsed or refractory CD7-positive hematologic cancers. "/><meta name="twitter:card" content="summary"/><meta name="twitter:title" content="New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma"/><meta name="twitter:image" content="https://cdn.sanity.io/images/0vv8moc6/ajmc/04663c88d2d04992175ced53fda8bb885d2d2ee8-1200x724.jpg?fit=crop&auto=format"/><meta name="twitter:site" content="@@AJMC_Journal"/><meta name="twitter:description" content="This study introduces a novel "all-in-one" strategy combining CD7 chimeric antigen receptor T-cell therapy with haploidentical hematopoietic stem-cell transplantation, showing significant potential to improve survival and reduce toxicities in patients with relapsed or refractory CD7-positive hematologic cancers. "/><meta name="robots" content="max-image-preview:large"/><meta name="robots" content="max-video-preview:-1"/><link rel="preconnect dns-prefetch" href="https://cmp.osano.com"/><link rel="preconnect dns-prefetch" href="https://res.lassomarketing.io"/><link rel="preconnect dns-prefetch" href="https://www.lightboxcdn.com"/><link rel="preconnect dns-prefetch" href="https://pub.doubleverify.com"/><link rel="preconnect dns-prefetch" href="https://cdn.doubleverify.com"/><link rel="preconnect dns-prefetch" href="https://cdn.segment.com"/><link rel="preconnect dns-prefetch" href="https://securepubads.g.doubleclick.net"/><link rel="preconnect dns-prefetch" href="https://pagead2.googlesyndication.com"/><link rel="preconnect dns-prefetch" href="https://cdn.sanity.io"/><link rel="preconnect dns-prefetch" href="https://www.google-analytics.com"/><link rel="preconnect dns-prefetch" href="https://www.googletagmanager.com"/><link rel="preconnect dns-prefetch" href="https://player.vimeo.com"/><link rel="preconnect dns-prefetch" href="https://youtube.com"/><link rel="preconnect dns-prefetch" href="https://connect.facebook.net"/><link rel="preconnect dns-prefetch" href="https://www.facebook.com"/><link rel="preconnect dns-prefetch" href="https://static.ads-twitter.com"/><link rel="preconnect dns-prefetch" href="https://ad.doubleclick.net"/><link rel="preload" href="https://securepubads.g.doubleclick.net/tag/js/gpt.js"/><link rel="preload" href="https://pub.doubleverify.com/signals/pub.js#ctx=20083417&cmp=DV464021"/><link rel="icon" href="/favicon.ico"/><script async="" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script><script src="https://pub.doubleverify.com/signals/pub.js#ctx=20083417&cmp=DV464021"></script><meta name="keywords" content="haploidentical HSCT ,CAR T-cell therapy ,CD7-Positive Leukemia/Lymphoma"/><script src="https://one.ajmc.com/tagmanager/scripts/one.js"></script><script>window.dataLayer = window.dataLayer || []; window.dataLayer.push({ event: "page_dimensions", pageTitle: "New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma", dimension9: "compendium/gene-therapy,topic/clinical,news", dimension11: "", dimension12: "", dimension13: "Articles", dimension14: "Kimberly Rath, PharmD", dimension15: "new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma", dimension18: "2024-05-09T14:16:29.396Z", dimension19: "", dimension20: "", });</script><script type="module"> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-NK5KQXS'); </script><script type="module"> var ALGOLIA_INSIGHTS_SRC = "https://cdn.jsdelivr.net/npm/search-insights@2.4.0"; !function(e,a,t,n,s,i,c){e.AlgoliaAnalyticsObject=s,e[s]=e[s]||function(){ (e[s].queue=e[s].queue||[]).push(arguments)},i=a.createElement(t),c=a.getElementsByTagName(t)[0], i.async=1,i.src=n,c.parentNode.insertBefore(i,c) }(window,document,"script",ALGOLIA_INSIGHTS_SRC,"aa");</script><link rel="canonical" href="https://www.ajmc.com/view/new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma"/><meta name="robots" content="max-image-preview:large"/><meta name="robots" content="max-video-preview:-1"/><meta name="next-head-count" content="13"/><script async="" type="text/javascript" src="https://www.lightboxcdn.com/static/lightbox_mjh.js"></script><script defer="" src="https://res.lassomarketing.io/scripts/lasso-imp-id-min.js" type="text/javascript"></script> <script defer="" type="text/javascript" src="https://www.googletagservices.com/tag/js/gpt.js"></script> <script type="module"> !function(){var analytics=window.analytics=window.analytics||[];if(!analytics.initialize)if(analytics.invoked)window.console&&console.error&&console.error("Segment snippet included twice.");else{analytics.invoked=!0;analytics.methods=["trackSubmit","trackClick","trackLink","trackForm","pageview","identify","reset","group","track","ready","alias","debug","page","once","off","on","addSourceMiddleware","addIntegrationMiddleware","setAnonymousId","addDestinationMiddleware"];analytics.factory=function(e){return function(){var t=Array.prototype.slice.call(arguments);t.unshift(e);analytics.push(t);return analytics}};for(var e=0;e<analytics.methods.length;e++){var key=analytics.methods[e];analytics[key]=analytics.factory(key)}analytics.load=function(key,e){var t=document.createElement("script");t.type="text/javascript";t.async=!0;t.src="https://cdn.segment.com/analytics.js/v1/" + key + "/analytics.min.js";var n=document.getElementsByTagName("script")[0];n.parentNode.insertBefore(t,n);analytics._loadOptions=e};analytics.SNIPPET_VERSION="4.13.1"; window.LassoImpressionID = lassoImpID(); analytics.load("BBbKMoOjmhsxPnbd2nO6osz3zq67DzuN"); analytics.page({ 'LassoImpressionID': window.LassoImpressionID }); }}(); </script> <link rel="preload" href="/_next/static/css/e5225e6dc4ca333b.css" as="style"/><link rel="stylesheet" href="/_next/static/css/e5225e6dc4ca333b.css" data-n-g=""/><link rel="preload" href="/_next/static/css/1fd9d1dcb68b7a42.css" as="style"/><link rel="stylesheet" href="/_next/static/css/1fd9d1dcb68b7a42.css" data-n-p=""/><link rel="preload" href="/_next/static/css/159521ba7be98a3c.css" as="style"/><link rel="stylesheet" href="/_next/static/css/159521ba7be98a3c.css" data-n-p=""/><noscript data-n-css=""></noscript><script defer="" nomodule="" src="/_next/static/chunks/polyfills-c67a75d1b6f99dc8.js"></script><script src="/_next/static/chunks/webpack-7bb91bc5bbba1ada.js" defer=""></script><script src="/_next/static/chunks/framework-45ce3d09104a2cae.js" defer=""></script><script src="/_next/static/chunks/main-c1ce322a402d266c.js" defer=""></script><script src="/_next/static/chunks/pages/_app-c3a05645a08041c3.js" defer=""></script><script src="/_next/static/chunks/8eec4907-bd18a9d50c17fbc1.js" defer=""></script><script src="/_next/static/chunks/065a3ddb-42216585c327b2a5.js" defer=""></script><script src="/_next/static/chunks/9814d858-cb162ab048445baf.js" defer=""></script><script src="/_next/static/chunks/69bd6bf3-c7219ac9ecb38ac9.js" defer=""></script><script src="/_next/static/chunks/f36c6662-e730e1316f9aa347.js" defer=""></script><script src="/_next/static/chunks/72585f70-0d4479e14d41a365.js" defer=""></script><script src="/_next/static/chunks/59b4e022-12a1c6f09c31aa87.js" defer=""></script><script src="/_next/static/chunks/aeb74aa0-4e0b515016d20a9f.js" defer=""></script><script src="/_next/static/chunks/e1efa4cc-06e900eb45581c19.js" defer=""></script><script src="/_next/static/chunks/4592-37f767f9d2e595fc.js" defer=""></script><script src="/_next/static/chunks/1212-e69ee8c76b24c02a.js" defer=""></script><script src="/_next/static/chunks/4179-91956f2d2c4bf724.js" defer=""></script><script src="/_next/static/chunks/9879-c84885d45ee98d34.js" defer=""></script><script src="/_next/static/chunks/9355-c793747e2dd7fab4.js" defer=""></script><script src="/_next/static/chunks/3499-b4daf1c9382343af.js" defer=""></script><script src="/_next/static/chunks/4386-1eb6319d7e5f2437.js" defer=""></script><script src="/_next/static/chunks/430-ec5773e97694cd78.js" defer=""></script><script src="/_next/static/chunks/173-0c8dbb3c1f76b4a8.js" defer=""></script><script src="/_next/static/chunks/7707-950f90aec08fbabe.js" defer=""></script><script src="/_next/static/chunks/475-90949f2271d616fd.js" defer=""></script><script src="/_next/static/chunks/4978-ee388caa09ad5169.js" defer=""></script><script src="/_next/static/chunks/pages/view/%5B...slug%5D-f8d94fe9e192d475.js" defer=""></script><script src="/_next/static/MDzUGgoo5zJ9FwYvn4DYi/_buildManifest.js" defer=""></script><script src="/_next/static/MDzUGgoo5zJ9FwYvn4DYi/_ssgManifest.js" defer=""></script><style id="__jsx-1661e6713d4eb9b5">.leaderboardAdWrapper.jsx-1661e6713d4eb9b5{min-height:90px;background:#fff}.leaderboardAdWrapper.jsx-1661e6713d4eb9b5 .AD728x90.jsx-1661e6713d4eb9b5{}@media screen and (min-width:768px){.leader-fixed.jsx-1661e6713d4eb9b5{position:fixed;margin-top:1rem;z-index:999999}}.leaderboardAdWrapper.jsx-1661e6713d4eb9b5 .AD728x90.jsx-1661e6713d4eb9b5 div[id*="google_ads_iframe"].jsx-1661e6713d4eb9b5:empty{height:0px!important}@media screen and (max-width:668px){.leaderboardAdWrapper.jsx-1661e6713d4eb9b5{min-height:0px;position:fixed;background:white;left:0;right:0;top:55px;padding-top:.5rem;padding-bottom:.25rem;z-index:9999}}</style><style id="__jsx-19ede9f0a5a45918">.jsx-19ede9f0a5a45918::-webkit-scrollbar{display:none}</style><style id="__jsx-ad50481d5ee26850">@media(min-width:980px)and (max-width:1200px){.article-detail.jsx-ad50481d5ee26850{width:47%}}@media(min-width:1201px)and (max-width:1400px){.article-detail.jsx-ad50481d5ee26850{width:55%}}</style></head><body><div id="__next" data-reactroot=""><div class="-mb-6"><div id="frame-nav" class="sticky top-0 z-[999999]"><div class="h-full w-full"><nav role="navigation" class=" w-full mx-auto hidden lg:block bg-white shadow-md relative"><div class="bg-primary" id="topnav"><div class="container px-4 relative justify-between h-16 flex items-center md:items-stretch mx-auto "><div class="h-full flex items-center flex-1 justify-between mr-4"><a role="img" aria-label="logo" class="focus:outline-none relative h-12 w-40 mr-6 flex items-center" href="/"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;object-position:left"/><noscript><img sizes="100vw" srcSet="/_next/image?url=%2Fajmc_logo_inverted.png&w=640&q=75 640w, /_next/image?url=%2Fajmc_logo_inverted.png&w=750&q=75 750w, /_next/image?url=%2Fajmc_logo_inverted.png&w=828&q=75 828w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1080&q=75 1080w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1200&q=75 1200w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1920&q=75 1920w, /_next/image?url=%2Fajmc_logo_inverted.png&w=2048&q=75 2048w, /_next/image?url=%2Fajmc_logo_inverted.png&w=3840&q=75 3840w" src="/_next/image?url=%2Fajmc_logo_inverted.png&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;object-position:left" loading="lazy"/></noscript></span></a><div class="hidden md:block"><div class="bg-primary py-2 whitespace-nowrap"><div class="mx-auto md:max-w-4xl lg:max-w-5xl xl:max-w-7xl "><div class="flex gap-4 items-end"><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">News<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/news" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">All News</a><a href="/press-release" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Press Releases</a><a href="/approvals-launches" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Product Approvals and Launches</a></div></div><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">Video<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/video-hub" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">All Video Types</a><a href="/interviews" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">AJMC TV</a><a href="/insights" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Insights</a><a href="/onlocation" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">OnLocation</a><a href="/payer-perspectives" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Payer Perspectives</a><a href="/peer-exchange" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Peer Exchange</a><a href="/post-conference-perspectives" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Post Conference Perspectives</a><a href="/stakeholder-summit" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Stakeholder Summit</a></div></div><a class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center text-sm tracking-normal capitalize text-white" href="/podcasts">Podcasts</a><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">Conferences<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/latest-conference" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Conference Coverage</a><a href="/conference" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Conference Listing</a><a href="/post-conference-perspectives" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Post Conference Perspectives</a></div></div><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">Journals<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/publications" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">All Journals</a><a href="/publications/issue" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">The American Journal of Managed Care</a><a href="/publications/ajac" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Population Health, Equity & Outcomes</a><a href="/publications/evidence-based-oncology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Evidence-Based Oncology</a><a href="/supplement" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">About Supplements and Featured Publications</a><a href="/publications/supplement" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Supplements and Featured Publications Issues</a><a href="/submit-a-manuscript" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Submit a Manuscript</a></div></div><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">Events<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/ivbmevents" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Institute for Value-Based Medicine</a><a href="https://pcoc.ajmc.com/" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Patient-Centered Oncology Care</a></div></div><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">Resources<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/interactive-tools" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Interactive Tools</a><a href="/clinical-spotlight" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Clinical Spotlight</a><a href="/custom-email" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Microsites</a><a href="/sponsored" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Sponsored Content</a></div></div><a class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center text-sm tracking-normal capitalize text-white" href="/continuing-education">CE</a><div class=" isolate z-[10000] " data-headlessui-state=""><button class="focus:outline-none border-b-2 border-transparent text-[15px] cursor-pointer h-full flex items-center tracking-normal capitalize text-white" type="button" aria-expanded="false" data-headlessui-state="">About AJMC<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><div class="sr-only"><a href="/editorial" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">AJMC Staff</a><a href="/anniversary" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Anniversary</a><a href="/about/seema-sonnad-nomination" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Seema Sonnad Award</a><a href="/partners" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Strategic Alliance Partners</a></div></div></div></div></div></div></div><div class="md:flex items-center justify-end hidden"><div class="flex items-center"><div class="md:pr-10 lg:pr-0 h-full flex items-center"><button class="w-6 h-6 relative"><svg xmlns="http://www.w3.org/2000/svg" class="text-white stroke-current icon icon-tabler icon-tabler-search" viewBox="0 0 24 24" stroke-width="1.5" stroke="currentColor" fill="none" stroke-linecap="round" stroke-linejoin="round"><path stroke="none" d="M0 0h24v24H0z"></path><circle cx="10" cy="10" r="7"></circle><line x1="21" y1="21" x2="15" y2="15"></line></svg></button><div class="hidden bg-secondary p-4 rounded shadow-lg top-16 right-0 overflow-hidden absolute grid place-items-center z-[99999] "><form method="GET" action="/search"><div class="relative"><div class="text-gray-600 absolute ml-3 inset-0 m-auto lg:w-4 lg:h-4 md:w-6 md:h-6"><button aria-label="submit" type="submit" class="absolute block inset-0"><svg xmlns="http://www.w3.org/2000/svg" class="text-gray-600 stroke-current icon icon-tabler icon-tabler-search" viewBox="0 0 24 24" stroke-width="2" stroke="currentColor" fill="none" stroke-linecap="round" stroke-linejoin="round"><path stroke="none" d="M0 0h24v24H0z"></path><circle cx="10" cy="10" r="7"></circle><line x1="21" y1="21" x2="15" y2="15"></line></svg></button></div><input type="text" required="" name="searchTerm" class="block border border-gray-200 focus:outline-none focus:border-indigo-700 lg:w-48 xl:w-64 rounded text-sm text-gray-800 pl-8 py-2" placeholder="Search"/></div></form></div></div></div><a href="https://one.ajmc.com/subscribe" class="bg-subscribe-btn rounded text-white py-1.5 px-3 text-[14px] ml-4 uppercase font-semibold">Subscribe</a></div></div></div><div class="bg-white" id="bottomnav"><div style="max-height:60px" class="px-4 transition-all container justify-between h-14 flex items-center md:items-stretch mx-auto"><div class="h-full w-full flex items-center justify-between relative"><div class="flex flex-row gap-2 mr-4"><div class="relative"><div class="block"><div class=""><div class="mx-auto md:max-w-4xl lg:max-w-5xl xl:max-w-7xl "><div class="flex gap-4 justify-start"><div class=" isolate z-[9999] " data-headlessui-state=""><button class="focus:outline-none rounded font-medium cursor-pointer h-full flex items-center text-xs md:text-sm h-[34px] px-2 py-2 md:px-4 tracking-normal capitalize brightness-[85%] bg-primary text-gray-50 lg:min-w-[140px] justify-between" type="button" aria-expanded="false" data-headlessui-state="">Specialty Area<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><nav role="navigation" aria-label="Specialty Area" class="sr-only"><div><a href="/compendium/biosimilars" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Biosimilars</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Cardiorenalmetabolic</span><a href="/compendium/cardiovascular" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Cardiovascular</a><a href="/compendium/ckd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Chronic Kidney Disease</a><a href="/compendium/diabetes" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Diabetes</a><a href="/compendium/heart-failure" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Heart Failure</a><a href="/compendium/type1diabetes" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Type 1 Diabetes</a></div><div><a href="/compendium/dermatology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Dermatology</a><a href="/compendium/alopecia" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Alopecia</a><a href="/compendium/atopic-dermatitis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Atopic Dermatitis</a><a href="/compendium/psoriasis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Psoriasis</a></div><div><a href="/compendium/gastroenterology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Gastroenterology</a></div><div><a href="/compendium/hematology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Hematology</a><a href="/compendium/all" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">ALL/AML</a><a href="/compendium/cll" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">CLL/SLL</a><a href="/compendium/gvhd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">GVHD</a><a href="/compendium/hemophilia" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Hemophilia</a><a href="/compendium/multiple-myeloma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Multiple Myeloma</a><a href="/compendium/myelodysplastic-syndromes" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Myelodysplastic Syndromes</a><a href="/compendium/mpn" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Myeloproliferative Neoplasms</a><a href="/compendium/nhl" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Non-Hodgkin Lymphoma</a><a href="/compendium/rareblood" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Rare Blood</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Hepatology</span><a href="/compendium/liver-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Liver</a></div><div><a href="/compendium/immunology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Immunology</a><a href="/compendium/autoimmune" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Autoimmune</a><a href="/compendium/Inflammation" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Inflammation</a><a href="/compendium/lupus" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Lupus</a><a href="/compendium/myasthenia-gravis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Myasthenia Gravis</a></div><div><a href="/compendium/infectious-disease" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Infectious Disease</a><a href="/compendium/covid-19" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">COVID-19</a><a href="/compendium/hiv" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">HIV</a><a href="/compendium/rsv" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">RSV</a><a href="/compendium/vaccines" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Vaccines</a></div><div><a href="/compendium/mental-health" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Mental Health</a><a href="/compendium/mdd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Major Depressive Disorder</a><a href="/compendium/sleep" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Sleep</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Neurology</span><a href="/compendium/dmd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Duchenne Muscular Dystrophy</a><a href="/compendium/epilepsy" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Epilepsy</a><a href="/compendium/multiple-sclerosis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Multiple Sclerosis</a><a href="/compendium/parkinson" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Parkinson Disease</a></div><div><a href="/compendium/obesity" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Obesity</a></div><div><a href="/compendium/oncology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Oncology</a><a href="/compendium/breast-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Breast Cancer</a><a href="/compendium/cholangiocarcinoma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Cholangiocarcinoma</a><a href="/compendium/colorectal-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Colorectal Cancer</a><a href="/compendium/immuno-oncology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Immuno-Oncology</a><a href="/compendium/liver-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Liver Cancer</a><a href="/compendium/lung-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Lung Cancer</a><a href="/compendium/nsclc" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Non–Small Cell Lung Cancer</a><a href="/compendium/ovarian-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Ovarian Cancer</a><a href="/compendium/prostate-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Prostate Cancer</a><a href="/compendium/skincancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Skin Cancer</a><a href="/compendium/soft-tissue-sarcoma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Soft Tissue Sarcoma</a></div><div><a href="/compendium/ophthalmology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Ophthalmology</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Pulmonology</span><a href="/compendium/copd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">COPD</a><a href="/compendium/pah" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Pulmonary Arterial Hypertension</a></div><div><a href="/compendium/raredisease" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Rare Disease</a><a href="/compendium/sma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Spinal Muscular Atrophy</a></div><div><a href="/compendium/respiratory" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Respiratory</a><a href="/compendium/asthma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Asthma</a><a href="/compendium/ipf" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Idiopathic Pulmonary Fibrosis</a></div><div><a href="/compendium/rheumatology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Rheumatology</a></div><div><a href="/compendium/womens-health" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Women's Health</a></div></nav></div></div></div></div></div></div><div class="relative"><div class="block"><div class=""><div class="mx-auto md:max-w-4xl lg:max-w-5xl xl:max-w-7xl "><div class="flex gap-4 justify-start"><div class=" isolate z-[9999] " data-headlessui-state=""><button class="focus:outline-none rounded font-medium cursor-pointer h-full flex items-center text-xs md:text-sm h-[34px] px-2 py-2 md:px-4 tracking-normal capitalize brightness-[85%] bg-primary text-gray-50 lg:min-w-[140px] justify-between" type="button" aria-expanded="false" data-headlessui-state="">Topics<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><nav role="navigation" aria-label="Topics" class="sr-only"><div><a href="/compendium/biosimilars" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Biosimilars</a></div><div><a href="/topic/center-on-health-equity-and-access" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Center on Health Equity & Access</a></div><div><a href="/compendium/digital-health" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Digital Health</a></div><div><a href="/formulary" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Formulary</a></div><div><a href="/compendium/gene-therapy" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Gene Therapy</a></div><div><a href="/guidelines" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Guidelines</a></div><div><a href="/topic/healthcare-cost" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Health Care Cost</a></div><div><a href="/topic/healthcare-delivery" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Health Care Delivery</a></div><div><a href="/topic/insurance" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Insurance</a></div><div><a href="/topic/policy" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Policy</a></div><div><a href="/compendium/population" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Population Health</a></div><div><a href="/approvals-launches" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Product Approvals and Launches</a></div><div><a href="/topic/technology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Technology</a></div><div><a href="/topic/value-based-care" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Value-Based Care</a></div></nav></div></div></div></div></div></div></div><div class="flex flex-1 items-center gap-3 overflow-hidden justify-start"><span class="text-md font-semibold whitespace-pre !text-primary filter brightness-75">Spotlight</span><ul id="spotlight-links" class="flex gap-2 h-4 overflow-hidden flex-wrap"><li class="text-xs pt-0.5 whitespace-pre cursor-pointer hover:underline text-gray-800"><a href="/ivbmevents?display=home">Free In-Person Regional Events Focused on Oncology and Population Health</a></li></ul></div></div></div></div></nav><nav class="lg:hidden"><div class="w-full shadow-md bg-primary sticky top-0 z-40"><div class="flex mx-auto container"><div class=" py-4 flex items-stretch justify-between mx-4 items-center w-full"><div class="flex items-center justify-end"><div class="flex items-center"><div class="h-full flex items-center"><button id="menu" aria-label="open menu" aria-expanded="false" class="focus:outline-none focus:ring-2 focus:ring-gray-700 rounded-md text-white"><svg width="30" height="30" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M21 10H3" stroke="#fff" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path><path d="M21 6H3" stroke="#fff" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path><path d="M21 14H3" stroke="#fff" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path><path d="M21 18H3" stroke="#fff" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"></path></svg></button></div></div></div><div aria-label="logo" role="img" tabindex="0" class="focus:outline-none relative h-10 w-40"><a role="img" aria-label="logo" class="focus:outline-none relative h-12 w-40 mr-6 flex items-center" href="/"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;object-position:center"/><noscript><img sizes="100vw" srcSet="/_next/image?url=%2Fajmc_logo_inverted.png&w=640&q=75 640w, /_next/image?url=%2Fajmc_logo_inverted.png&w=750&q=75 750w, /_next/image?url=%2Fajmc_logo_inverted.png&w=828&q=75 828w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1080&q=75 1080w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1200&q=75 1200w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1920&q=75 1920w, /_next/image?url=%2Fajmc_logo_inverted.png&w=2048&q=75 2048w, /_next/image?url=%2Fajmc_logo_inverted.png&w=3840&q=75 3840w" src="/_next/image?url=%2Fajmc_logo_inverted.png&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;object-position:center" loading="lazy"/></noscript></span></a></div><div class="relative w-8 h-8 my grid items-center"><a class="absolute lg:hidden inset-0 mt-1" href="/search"><svg xmlns="http://www.w3.org/2000/svg" class="text-white stroke-current icon icon-tabler icon-tabler-search" viewBox="0 0 24 24" stroke-width="1.5" stroke="currentColor" fill="none" stroke-linecap="round" stroke-linejoin="round"><path stroke="none" d="M0 0h24v24H0z"></path><circle cx="10" cy="10" r="7"></circle><line x1="21" y1="21" x2="15" y2="15"></line></svg></a></div></div></div><div style="max-height:50px" class="bg-white px-4 transition-all h-12 md:items-stretch mx-auto" id="bottomnav-mobile"><div class="container justify-between h-12 flex items-center md:items-stretch mx-auto"><div class="h-full w-full flex items-center justify-between relative"><div class="flex flex-1 justify-center xs:justify-start items-center relative group h-full z-50 gap-2"><div class="z-1 relative"><div class="block"><div class=""><div class="mx-auto md:max-w-4xl lg:max-w-5xl xl:max-w-7xl "><div class="flex gap-4 justify-start"><div class=" isolate z-[9999] " data-headlessui-state=""><button class="focus:outline-none rounded font-medium cursor-pointer h-full flex items-center text-xs md:text-sm h-[34px] px-2 py-2 md:px-4 tracking-normal capitalize brightness-[85%] bg-primary text-gray-50 lg:min-w-[140px] justify-between" type="button" aria-expanded="false" data-headlessui-state="">Specialty Area<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><nav role="navigation" aria-label="Specialty Area" class="sr-only"><div><a href="/compendium/biosimilars" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Biosimilars</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Cardiorenalmetabolic</span><a href="/compendium/cardiovascular" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Cardiovascular</a><a href="/compendium/ckd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Chronic Kidney Disease</a><a href="/compendium/diabetes" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Diabetes</a><a href="/compendium/heart-failure" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Heart Failure</a><a href="/compendium/type1diabetes" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Type 1 Diabetes</a></div><div><a href="/compendium/dermatology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Dermatology</a><a href="/compendium/alopecia" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Alopecia</a><a href="/compendium/atopic-dermatitis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Atopic Dermatitis</a><a href="/compendium/psoriasis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Psoriasis</a></div><div><a href="/compendium/gastroenterology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Gastroenterology</a></div><div><a href="/compendium/hematology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Hematology</a><a href="/compendium/all" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">ALL/AML</a><a href="/compendium/cll" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">CLL/SLL</a><a href="/compendium/gvhd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">GVHD</a><a href="/compendium/hemophilia" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Hemophilia</a><a href="/compendium/multiple-myeloma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Multiple Myeloma</a><a href="/compendium/myelodysplastic-syndromes" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Myelodysplastic Syndromes</a><a href="/compendium/mpn" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Myeloproliferative Neoplasms</a><a href="/compendium/nhl" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Non-Hodgkin Lymphoma</a><a href="/compendium/rareblood" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Rare Blood</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Hepatology</span><a href="/compendium/liver-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Liver</a></div><div><a href="/compendium/immunology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Immunology</a><a href="/compendium/autoimmune" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Autoimmune</a><a href="/compendium/Inflammation" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Inflammation</a><a href="/compendium/lupus" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Lupus</a><a href="/compendium/myasthenia-gravis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Myasthenia Gravis</a></div><div><a href="/compendium/infectious-disease" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Infectious Disease</a><a href="/compendium/covid-19" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">COVID-19</a><a href="/compendium/hiv" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">HIV</a><a href="/compendium/rsv" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">RSV</a><a href="/compendium/vaccines" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Vaccines</a></div><div><a href="/compendium/mental-health" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Mental Health</a><a href="/compendium/mdd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Major Depressive Disorder</a><a href="/compendium/sleep" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Sleep</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Neurology</span><a href="/compendium/dmd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Duchenne Muscular Dystrophy</a><a href="/compendium/epilepsy" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Epilepsy</a><a href="/compendium/multiple-sclerosis" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Multiple Sclerosis</a><a href="/compendium/parkinson" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Parkinson Disease</a></div><div><a href="/compendium/obesity" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Obesity</a></div><div><a href="/compendium/oncology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Oncology</a><a href="/compendium/breast-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Breast Cancer</a><a href="/compendium/cholangiocarcinoma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Cholangiocarcinoma</a><a href="/compendium/colorectal-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Colorectal Cancer</a><a href="/compendium/immuno-oncology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Immuno-Oncology</a><a href="/compendium/liver-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Liver Cancer</a><a href="/compendium/lung-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Lung Cancer</a><a href="/compendium/nsclc" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Non–Small Cell Lung Cancer</a><a href="/compendium/ovarian-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Ovarian Cancer</a><a href="/compendium/prostate-cancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Prostate Cancer</a><a href="/compendium/skincancer" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Skin Cancer</a><a href="/compendium/soft-tissue-sarcoma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Soft Tissue Sarcoma</a></div><div><a href="/compendium/ophthalmology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Ophthalmology</a></div><div><span class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Pulmonology</span><a href="/compendium/copd" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">COPD</a><a href="/compendium/pah" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Pulmonary Arterial Hypertension</a></div><div><a href="/compendium/raredisease" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Rare Disease</a><a href="/compendium/sma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Spinal Muscular Atrophy</a></div><div><a href="/compendium/respiratory" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Respiratory</a><a href="/compendium/asthma" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Asthma</a><a href="/compendium/ipf" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Idiopathic Pulmonary Fibrosis</a></div><div><a href="/compendium/rheumatology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Rheumatology</a></div><div><a href="/compendium/womens-health" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Women's Health</a></div></nav></div></div></div></div></div></div><div class="z-1 relative"><div class="block"><div class=""><div class="mx-auto md:max-w-4xl lg:max-w-5xl xl:max-w-7xl "><div class="flex gap-4 justify-start"><div class=" isolate z-[9999] " data-headlessui-state=""><button class="focus:outline-none rounded font-medium cursor-pointer h-full flex items-center text-xs md:text-sm h-[34px] px-2 py-2 md:px-4 tracking-normal capitalize brightness-[85%] bg-primary text-gray-50 lg:min-w-[140px] justify-between" type="button" aria-expanded="false" data-headlessui-state="">Topics<svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="m11.998 17 7-8h-14z"></path></svg></button><nav role="navigation" aria-label="Topics" class="sr-only"><div><a href="/compendium/biosimilars" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Biosimilars</a></div><div><a href="/topic/center-on-health-equity-and-access" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Center on Health Equity & Access</a></div><div><a href="/compendium/digital-health" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Digital Health</a></div><div><a href="/formulary" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Formulary</a></div><div><a href="/compendium/gene-therapy" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Gene Therapy</a></div><div><a href="/guidelines" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Guidelines</a></div><div><a href="/topic/healthcare-cost" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Health Care Cost</a></div><div><a href="/topic/healthcare-delivery" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Health Care Delivery</a></div><div><a href="/topic/insurance" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Insurance</a></div><div><a href="/topic/policy" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Policy</a></div><div><a href="/compendium/population" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Population Health</a></div><div><a href="/approvals-launches" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Product Approvals and Launches</a></div><div><a href="/topic/technology" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Technology</a></div><div><a href="/topic/value-based-care" class="flex gap-x-4 py-2 text-sm font-semibold leading-6 text-blue-600 underline">Value-Based Care</a></div></nav></div></div></div></div></div></div></div></div></div></div></div><div class="fixed top-0 w-[85vw] h-full transform -translate-x-full z-40 transition duration-300 lg:hidden min-h-screen bg-primary shadow-lg" id="mobile-nav"><div class="w-full h-full shadow-lg z-40 fixed overflow-y-auto top-0 flex-col justify-between xl:hidden pb-4 transition duration-500 ease-in-out"><div class="px-5 h-full"><div class="flex flex-col justify-between h-full w-full"><div><div class="mt-6 flex w-full items-center justify-between"><div class="border-b border-gray-200 pb-2 flex items-center justify-between w-full"><div aria-label="logo" role="img" tabindex="0" class="focus:outline-none relative h-16 w-40 "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;object-position:left"/><noscript><img sizes="100vw" srcSet="/_next/image?url=%2Fajmc_logo_inverted.png&w=640&q=75 640w, /_next/image?url=%2Fajmc_logo_inverted.png&w=750&q=75 750w, /_next/image?url=%2Fajmc_logo_inverted.png&w=828&q=75 828w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1080&q=75 1080w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1200&q=75 1200w, /_next/image?url=%2Fajmc_logo_inverted.png&w=1920&q=75 1920w, /_next/image?url=%2Fajmc_logo_inverted.png&w=2048&q=75 2048w, /_next/image?url=%2Fajmc_logo_inverted.png&w=3840&q=75 3840w" src="/_next/image?url=%2Fajmc_logo_inverted.png&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;object-position:left" loading="lazy"/></noscript></span></div><button aria-label="close menu" class="focus:outline-none focus:ring-2 rounded-md text-white pl-8 font-bold"><svg width="18" height="18" viewBox="0 0 14 14" fill="#fff" xmlns="http://www.w3.org/2000/svg"><path d="M13 1L1 13" stroke="#fff" stroke-linecap="round" stroke-width="2" stroke-linejoin="round"></path><path d="M1 1L13 13" stroke="#fff" stroke-linecap="round" stroke-width="2" stroke-linejoin="round"></path></svg></button></div></div><ul role="list" class="flex flex-1 flex-col gap-y-7 mt-6"><li><ul role="list" class="-mx-2 space-y-1"><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>Spotlight</button></div></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>News</button></div></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>Video</button></div></li><li><a class="hover:bg-gray-500 block rounded-md py-2 pr-2 pl-10 text-sm leading-6 font-semibold text-gray-50" href="/podcasts"><span>Podcasts</span></a></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>Conferences</button></div></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>Journals</button></div></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>Events</button></div></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>Resources</button></div></li><li><a class="hover:bg-gray-500 block rounded-md py-2 pr-2 pl-10 text-sm leading-6 font-semibold text-gray-50" href="/continuing-education"><span>CE</span></a></li><li><div data-headlessui-state=""><button class="hover:bg-gray-500 flex items-center w-full text-left p-2 gap-x-3 text-sm leading-6 font-semibold text-gray-50" id="headlessui-disclosure-button-undefined" type="button" aria-expanded="false" data-headlessui-state=""><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 320 512" class="text-gray-50 h-5 w-5 shrink-0" aria-hidden="true" height="1em" width="1em" xmlns="http://www.w3.org/2000/svg"><path d="M285.476 272.971L91.132 467.314c-9.373 9.373-24.569 9.373-33.941 0l-22.667-22.667c-9.357-9.357-9.375-24.522-.04-33.901L188.505 256 34.484 101.255c-9.335-9.379-9.317-24.544.04-33.901l22.667-22.667c9.373-9.373 24.569-9.373 33.941 0L285.475 239.03c9.373 9.372 9.373 24.568.001 33.941z"></path></svg>About AJMC</button></div></li><li><a class="hover:bg-gray-500 block rounded-md py-2 pr-2 pl-10 text-sm leading-6 font-semibold text-gray-50" href="https://one.ajmc.com/subscribe"><span>Subscribe</span></a></li></ul></li></ul><div class="flex md:hidden mt-4 items-center gap-2 mt-6 pt-6 border-t"><a rel="noreferrer noopener" target="_blank" href="https://www.facebook.com/TheAmericanJournalOfManagedCare"><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 448 512" color="#fff" style="color:#fff" height="24" width="24" xmlns="http://www.w3.org/2000/svg"><path d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg></a><a rel="noreferrer noopener" target="_blank" href="https://twitter.com/AJMC_Journal"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" width="21" height="21" viewBox="12.65 12.65 118.02 118.02"><g transform="translate(1.4065934065934016 1.4065934065934016) scale(2.81 2.81)"><path d="M 11 4 C 7.134 4 4 7.134 4 11 L 4 39 C 4 42.866 7.134 46 11 46 L 39 46 C 42.866 46 46 42.866 46 39 L 46 11 C 46 7.134 42.866 4 39 4 L 11 4 z M 13.085938 13 L 21.023438 13 L 26.660156 21.009766 L 33.5 13 L 36 13 L 27.789062 22.613281 L 37.914062 37 L 29.978516 37 L 23.4375 27.707031 L 15.5 37 L 13 37 L 22.308594 26.103516 L 13.085938 13 z M 16.914062 15 L 31.021484 35 L 34.085938 35 L 19.978516 15 L 16.914062 15 z" fill="#FFFFFF"></path></g></svg></a><a rel="noreferrer noopener" target="_blank" href="https://www.linkedin.com/company/american-journal-of-managed-care/"><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 448 512" color="#fff" style="color:#fff" height="27" width="27" xmlns="http://www.w3.org/2000/svg"><path d="M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z"></path></svg></a><a rel="noreferrer noopener" target="_blank" href="https://www.instagram.com/ajmcjournal/"><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 448 512" color="#fff" style="color:#fff" height="24" width="24" xmlns="http://www.w3.org/2000/svg"><path d="M224,202.66A53.34,53.34,0,1,0,277.36,256,53.38,53.38,0,0,0,224,202.66Zm124.71-41a54,54,0,0,0-30.41-30.41c-21-8.29-71-6.43-94.3-6.43s-73.25-1.93-94.31,6.43a54,54,0,0,0-30.41,30.41c-8.28,21-6.43,71.05-6.43,94.33S91,329.26,99.32,350.33a54,54,0,0,0,30.41,30.41c21,8.29,71,6.43,94.31,6.43s73.24,1.93,94.3-6.43a54,54,0,0,0,30.41-30.41c8.35-21,6.43-71.05,6.43-94.33S357.1,182.74,348.75,161.67ZM224,338a82,82,0,1,1,82-82A81.9,81.9,0,0,1,224,338Zm85.38-148.3a19.14,19.14,0,1,1,19.13-19.14A19.1,19.1,0,0,1,309.42,189.74ZM400,32H48A48,48,0,0,0,0,80V432a48,48,0,0,0,48,48H400a48,48,0,0,0,48-48V80A48,48,0,0,0,400,32ZM382.88,322c-1.29,25.63-7.14,48.34-25.85,67s-41.4,24.63-67,25.85c-26.41,1.49-105.59,1.49-132,0-25.63-1.29-48.26-7.15-67-25.85s-24.63-41.42-25.85-67c-1.49-26.42-1.49-105.61,0-132,1.29-25.63,7.07-48.34,25.85-67s41.47-24.56,67-25.78c26.41-1.49,105.59-1.49,132,0,25.63,1.29,48.33,7.15,67,25.85s24.63,41.42,25.85,67.05C384.37,216.44,384.37,295.56,382.88,322Z"></path></svg></a><a rel="noreferrer noopener" target="_blank" href="/rss"></a></div></div></div></div></div></div></nav></div></div><div class="container px-4 mx-auto pl-2 pr-2 sm:h-[98px] sm:w-[728px]"><div id="leaderboardWrapper" class="jsx-1661e6713d4eb9b5 leaderboardAdWrapper mx-auto mt-1 flex min-h-0 md:min-h-[90px] justify-center items-center flex-col relative z-[99999] "><div class="jsx-1661e6713d4eb9b5 bg-white md:-translate-x-4"><div class="jsx-1661e6713d4eb9b5 text-[8px] text-center text-gray-600 hidden relative">Advertisement</div><div id="div-gpt-ad-top" class="jsx-1661e6713d4eb9b5 AD728x90 mx-auto text-center x"></div></div></div></div><hr class="mt-8 pt-8 -mb-4 pb-0"/><div id="new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma" class="container mx-auto flex m-1 min-h-[57vh] px-4"><div class="flex-auto w-[calc(100%-300px)] pr-0 md:pr-6 mt-16 sm:mt-0"><div class="m-2 md:my-2 md:ml-2 md:pr-12"><div class="hidden md:block fixed"><div class="md:absolute md:left-[557px] lg:left-[742px] xl:left-[942px] flex flex-col justify-center bg-white h-fit w-fit py-3 px-[.35rem] border border-[#DDDDDD] rounded-full"><button class="group mt-1"><button aria-label="linkedin" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 448 512" style="color:#818285;margin-bottom:6px;cursor:pointer" height="1.25rem" width="1.25rem" xmlns="http://www.w3.org/2000/svg"><path d="M100.28 448H7.4V148.9h92.88zM53.79 108.1C24.09 108.1 0 83.5 0 53.8a53.79 53.79 0 0 1 107.58 0c0 29.7-24.1 54.3-53.79 54.3zM447.9 448h-92.68V302.4c0-34.7-.7-79.2-48.29-79.2-48.29 0-55.69 37.7-55.69 76.7V448h-92.78V148.9h89.08v40.8h1.3c12.4-23.5 42.69-48.3 87.88-48.3 94 0 111.28 61.9 111.28 142.3V448z"></path></svg></button></button><button class="group"><button aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg stroke="currentColor" fill="currentColor" stroke-width="0" version="1.2" baseProfile="tiny" viewBox="0 0 24 24" style="color:#818285;margin-bottom:6px;cursor:pointer" height="32" width="32" xmlns="http://www.w3.org/2000/svg"><path d="M13 10h3v3h-3v7h-3v-7h-3v-3h3v-1.255c0-1.189.374-2.691 1.118-3.512.744-.823 1.673-1.233 2.786-1.233h2.096v3h-2.1c-.498 0-.9.402-.9.899v2.101z"></path></svg></button></button><button class="group"><button aria-label="twitter" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 512 512" style="color:#818285;margin-bottom:10px;cursor:pointer" height="1.25rem" width="1.25rem" xmlns="http://www.w3.org/2000/svg"><path d="M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z"></path></svg></button></button><button class="group"><button aria-label="email" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg stroke="currentColor" fill="currentColor" stroke-width="0" viewBox="0 0 24 24" style="color:#818285;margin-bottom:6px;cursor:pointer" height="1.25rem" width="1.25rem" xmlns="http://www.w3.org/2000/svg"><path fill="none" d="M0 0h24v24H0V0z"></path><path d="M22 6c0-1.1-.9-2-2-2H4c-1.1 0-2 .9-2 2v12c0 1.1.9 2 2 2h16c1.1 0 2-.9 2-2V6zm-2 0l-8 4.99L4 6h16zm0 12H4V8l8 5 8-5v10z"></path></svg></button></button><button class="group mb-4 "><a class="cursor-pointer flex justify-center"><svg stroke="currentColor" fill="none" stroke-width="2" viewBox="0 0 24 24" stroke-linecap="round" stroke-linejoin="round" style="color:#818285;margin-bottom:6px;background:white;cursor:pointer" height="1.25rem" width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-05-09T14:16:29.396">May 9, 2024</time></div><h1 class="text-[26px] font-medium leading-8">New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg fill="#DC7633" xmlns="http://www.w3.org/2000/svg" width="32" zoomAndPan="magnify" viewBox="0 0 375 374.9999" height="32" preserveAspectRatio="xMidYMid meet" version="1.0"><defs><path d="M 7.09375 7.09375 L 367.84375 7.09375 L 367.84375 367.84375 L 7.09375 367.84375 Z M 7.09375 7.09375 " fill="#000000"></path></defs><g><path d="M 187.46875 7.09375 C 87.851562 7.09375 7.09375 87.851562 7.09375 187.46875 C 7.09375 287.085938 87.851562 367.84375 187.46875 367.84375 C 287.085938 367.84375 367.84375 287.085938 367.84375 187.46875 C 367.84375 87.851562 287.085938 7.09375 187.46875 7.09375 " fill-opacity="1" fill-rule="nonzero" fill="#000000"></path></g><g transform="translate(85, 75)"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" version="1.1" height="215" width="215"><path d="M18.244 2.25h3.308l-7.227 8.26 8.502 11.24H16.17l-5.214-6.817L4.99 21.75H1.68l7.73-8.835L1.254 2.25H8.08l4.713 6.231zm-1.161 17.52h1.833L7.084 4.126H5.117z" fill="#ffffff"></path></svg> </g></svg></button><button aria-label="linkedin" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#007fb1"></circle><path d="M20.4,44h5.4V26.6h-5.4V44z M23.1,18c-1.7,0-3.1,1.4-3.1,3.1c0,1.7,1.4,3.1,3.1,3.1 c1.7,0,3.1-1.4,3.1-3.1C26.2,19.4,24.8,18,23.1,18z M39.5,26.2c-2.6,0-4.4,1.4-5.1,2.8h-0.1v-2.4h-5.2V44h5.4v-8.6 c0-2.3,0.4-4.5,3.2-4.5c2.8,0,2.8,2.6,2.8,4.6V44H46v-9.5C46,29.8,45,26.2,39.5,26.2z" fill="white"></path></svg></button><button title="New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma" aria-label="pinterest" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#cb2128"></circle><path d="M32,16c-8.8,0-16,7.2-16,16c0,6.6,3.9,12.2,9.6,14.7c0-1.1,0-2.5,0.3-3.7 c0.3-1.3,2.1-8.7,2.1-8.7s-0.5-1-0.5-2.5c0-2.4,1.4-4.1,3.1-4.1c1.5,0,2.2,1.1,2.2,2.4c0,1.5-0.9,3.7-1.4,5.7 c-0.4,1.7,0.9,3.1,2.5,3.1c3,0,5.1-3.9,5.1-8.5c0-3.5-2.4-6.1-6.7-6.1c-4.9,0-7.9,3.6-7.9,7.7c0,1.4,0.4,2.4,1.1,3.1 c0.3,0.3,0.3,0.5,0.2,0.9c-0.1,0.3-0.3,1-0.3,1.3c-0.1,0.4-0.4,0.6-0.8,0.4c-2.2-0.9-3.3-3.4-3.3-6.1c0-4.5,3.8-10,11.4-10 c6.1,0,10.1,4.4,10.1,9.2c0,6.3-3.5,11-8.6,11c-1.7,0-3.4-0.9-3.9-2c0,0-0.9,3.7-1.1,4.4c-0.3,1.2-1,2.5-1.6,3.4 c1.4,0.4,3,0.7,4.5,0.7c8.8,0,16-7.2,16-16C48,23.2,40.8,16,32,16z" fill="white"></path></svg></button><button aria-label="email" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">This study introduces a novel "all-in-one" strategy combining CD7 chimeric antigen receptor T-cell therapy with haploidentical hematopoietic stem-cell transplantation, showing significant potential to improve survival and reduce toxicities in patients with relapsed or refractory CD7-positive hematologic cancers. </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">In a recent study published in <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.nejm.org/doi/full/10.1056/NEJMoa2313812"><em>The New England Journal of Medicine</em></a>, researchers introduced a novel "all-in-one" strategy that combines CD7 <a target="_blank" href="https://www.ajmc.com/compendium/gene-therapy">chimeric antigen receptor (CAR) T-cell therapy</a> with haploidentical hematopoietic stem-cell transplantation (HSCT) to treat patients with relapsed or refractory CD7-positive leukemia and lymphoma.<sup class="text-inherit">1</sup></p><p class="pb-2"></p><p class="pb-2">Relapsed or refractory hematologic cancers typically have a dire prognosis, with traditional treatments often leading to a 5-year overall survival of less than 20%. Toxicities from pretransplant conditioning and graft-vs-host disease (GVHD) prophylaxis have limited the integration of CAR T-cell therapy as a bridge to allogeneic HSCT.<sup class="text-inherit">2</sup> This all-in-one strategy avoids traditional pharmacologic myeloablation and GVHD prophylaxis and has shown promising results for patients with limited therapeutic options.</p><p class="pb-2"></p><p class="pb-2">The researchers noted, "Our findings suggest that sequential CD7 CAR T-cell therapy and haploidentical HSCT is safe and effective, with remission and serious but reversible adverse events. This strategy offers a feasible approach for patients with CD7-positive tumors who are ineligible for conventional allogeneic HSCT."</p><p class="pb-2"></p><div class=""><div style="width:30%;float:left;max-width:525px;margin:0 1.5rem 1.5rem 0;clear:both;cursor:pointer" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%271200%27%20height=%27724%27/%3e"/></span><img alt="Blood analysis | Image Credit: Parilov - stock.adobe.com" title="Blood analysis | Image Credit: Parilov - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Blood analysis | Image Credit: Parilov - stock.adobe.com" title="Blood analysis | Image Credit: Parilov - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbf0fd40c2eaca790ecb7789da62cf293a90a2b79-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1x, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbf0fd40c2eaca790ecb7789da62cf293a90a2b79-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 2x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbf0fd40c2eaca790ecb7789da62cf293a90a2b79-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2">Investigators have introduced a treatment combination of combines CD7 T-cell therapy and haploidentical HSCT to treat patients with relapsed or refractory CD7-positive leukemia and lymphoma | Image Credit: Parilov - stock.adobe.com</p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/bf0fd40c2eaca790ecb7789da62cf293a90a2b79-1200x724.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">The study, completed at the Bone Marrow Transplantation Center at Zhejiang University School of Medicine, involved 10 patients who underwent sequential therapy, including 7 with acute myeloid leukemia, 2 with T-cell acute lymphoblastic leukemia, and 1 with T-cell lymphoblastic lymphoma (grade IVa). These patients had previously shown poor responses to conventional treatments, completing a median of 9.5 (range, 4-15) therapy courses.</p><p class="pb-2"></p><p class="pb-2">Undergoing sequential therapy<strong>,</strong> starting with CD7 CAR T-cell therapy followed by haploidentical HSCT<strong>, </strong>all patients achieved complete remission, albeit with incomplete hematologic recovery. At 1 year post treatment, the overall survival rate was 68% (95% CI, 43%-100%), and the disease-free survival rate was 54% (95% CI, 29%-100%). The absence of pharmacologic myeloablation and GVHD prophylaxis drugs, relying instead on the immunosuppressive effects of the CAR T cells, presents a less toxic and potentially more effective treatment method.</p><p class="pb-2"></p><p class="pb-2">Serious but reversible adverse events were reported, including grade 4 pancytopenia observed in all patients following CAR T-cell therapy, which was expected due to the therapy's mechanism. Following HSCT, 1 patient died from septic shock and another from encephalitis, highlighting the treatment's significant risks. Additionally, 3 patients developed grade 2 HSCT-associated acute GVHD. The median follow-up was 15.1 (range, 3.1-24.0) months after CAR T-cell therapy. Six patients remained in minimal residual disease–negative complete remission during the follow-up period.</p><p class="pb-2"></p><p class="pb-2">The researchers acknowledged the limitations of their study, including its small sample size and the exploratory nature of the treatment.</p><p class="pb-2"></p><p class="pb-2">They noted that "because we were evaluating a new therapeutic strategy, the findings of this study still need to be extended and confirmed in a larger and more homogeneous cohort of patients."</p><p class="pb-2"></p><p class="pb-2">Although the results of the study are promising, the authors acknowledge the need for larger, more definitive trials to confirm these results and potentially expand the therapy's application.</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Hu Y, Zhang M, Yang T, et al. Sequential CD7 CAR T-cell therapy and allogeneic HSCT without GVHD prophylaxis. <em>N Engl J Med</em>. 2024;390(16):1467-1480. doi:10.1056/NEJMoa2313812</p><p class="pb-2">2. Ellard R, Kenyon M, Hutt D, et al. The EBMT immune effector cell nursing guidelines on CAR-T therapy: a framework for patient care and managing common toxicities. <em>Clin Hematol Int</em>. 2022;4(3):75-88. doi:10.1007/s44228-022-00004-8</p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/navigating-healthcare-access-and-decision-making"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/patient-selection-and-personalized-treatment-strategies"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/emerging-horizons-in-her2-directed-nsclc-treatments"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/managing-treatment-challenges-in-her2-directed-therapies"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/real-world-outcomes-in-her2-positive-nsclc"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="4 KOLs are featured in this series" title="4 KOLs are featured in this series" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fbae96e4a31573dfc8f43691290303d02008b15c4-1335x712.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/the-role-of-testing-for-c-difficile-in-clinical-practice"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="1 expert in this video" title="1 expert in this video" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="1 expert in this video" title="1 expert in this video" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/utilizing-antibiotics-in-treatment-of-c-difficile"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="1 expert in this video" title="1 expert in this video" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="1 expert in this video" title="1 expert in this video" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5a87648f7abba8a971c7928bd318187bf708e246-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/looking-ahead-anticipating-changes-in-lupus-guidelines-and-clinical-practice"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="1 KOL is featured in this series." title="1 KOL is featured in this series." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="1 KOL is featured in this series." title="1 KOL is featured in this series." sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/from-guidelines-to-practice-advancing-lupus-nephritis-treatment"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="1 KOL is featured in this series." title="1 KOL is featured in this series." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="1 KOL is featured in this series." title="1 KOL is featured in this series." sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff52b9836d747de80f88cb878807eca847840e7a3-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/impact-of-treatment-delays-on-patient-outcomes"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="Justin Oldham, MD, MS, an expert on IPF" title="Justin Oldham, MD, MS, an expert on IPF" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Justin Oldham, MD, MS, an expert on IPF" title="Justin Oldham, MD, MS, an expert on IPF" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81378af81ea01473112fda9db15216dd52b1a856-1920x1080.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a></div></div><div class="relative block sm:hidden"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448.jpg?fit=crop&auto=format" alt="Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent">Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study in Japan found that antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e5c760c89948ea062bc8055186b9134ab330099-3498x2332.jpg?fit=crop&auto=format" alt="Lonely patient | Image Credit: amazing studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent">Social Isolation Linked to Increased Mortality in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD), highlighting the need for targeted interventions to address this issue.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/453ff95d3edc29442e2af71658751e2f26adc78e-2500x2500.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value?utm_source=www.ajmc.com&utm_medium=relatedContent">Insurance Insights: Dr Jason Shafrin Estimates DMD Insurance Value</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we're talking with the author of a study published in the July 2024 issue of The American Journal of Managed Care® that estimates the insurance value of novel Duchenne muscular dystrophy (DMD) treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8b89f6523b42f0e4eac2c396f686ac915160fbf-1200x738.jpg?fit=crop&auto=format" alt="Clinical trial results-Egor-stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib?utm_source=www.ajmc.com&utm_medium=relatedContent">Progression-Free Survival in Relapsed Multiple Myeloma Extended With Ixazomib, Data Show</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite challenges such as high attrition rates and adverse events, the trial highlights the value of established therapies in improving outcomes, particularly in regions with limited access to chimeric antigen receptor T cells and bispecific antibodies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/27d488950c5a56c184f46ca9ccce51baadec1a29-5607x3738.jpg?fit=crop&auto=format" alt="FDA headquarters | Image Credit: Grandbrothers - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application?utm_source=www.ajmc.com&utm_medium=relatedContent">Avutometinib With Defactinib for Recurrent KRAS Mutant LGSOC Completes Rolling New Drug Application</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/gillian-mcgovern">Gillian McGovern</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If approved, the combination regimen would be the first FDA-approved treatment for adults with recurrent KRAS mutant low-grade serous ovarian cancer (LGSOC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448.jpg?fit=crop&auto=format" alt="Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent">Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study in Japan found that antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e5c760c89948ea062bc8055186b9134ab330099-3498x2332.jpg?fit=crop&auto=format" alt="Lonely patient | Image Credit: amazing studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent">Social Isolation Linked to Increased Mortality in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD), highlighting the need for targeted interventions to address this issue.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/453ff95d3edc29442e2af71658751e2f26adc78e-2500x2500.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value?utm_source=www.ajmc.com&utm_medium=relatedContent">Insurance Insights: Dr Jason Shafrin Estimates DMD Insurance Value</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we're talking with the author of a study published in the July 2024 issue of The American Journal of Managed Care® that estimates the insurance value of novel Duchenne muscular dystrophy (DMD) treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8b89f6523b42f0e4eac2c396f686ac915160fbf-1200x738.jpg?fit=crop&auto=format" alt="Clinical trial results-Egor-stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib?utm_source=www.ajmc.com&utm_medium=relatedContent">Progression-Free Survival in Relapsed Multiple Myeloma Extended With Ixazomib, Data Show</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite challenges such as high attrition rates and adverse events, the trial highlights the value of established therapies in improving outcomes, particularly in regions with limited access to chimeric antigen receptor T cells and bispecific antibodies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/27d488950c5a56c184f46ca9ccce51baadec1a29-5607x3738.jpg?fit=crop&auto=format" alt="FDA headquarters | Image Credit: Grandbrothers - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application?utm_source=www.ajmc.com&utm_medium=relatedContent">Avutometinib With Defactinib for Recurrent KRAS Mutant LGSOC Completes Rolling New Drug Application</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/gillian-mcgovern">Gillian McGovern</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If approved, the combination regimen would be the first FDA-approved treatment for adults with recurrent KRAS mutant low-grade serous ovarian cancer (LGSOC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma","datePublished":"2024-05-09T14:16:29.396Z","dateModified":"2024-05-09T14:16:32Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/04663c88d2d04992175ced53fda8bb885d2d2ee8-1200x724.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"haploidentical HSCT ,CAR T-cell therapy ,CD7-Positive Leukemia/Lymphoma","articleBody":"In a recent study published in The New England Journal of Medicine, researchers introduced a novel \"all-in-one\" strategy that combines CD7 chimeric antigen receptor (CAR) T-cell therapy with haploidentical hematopoietic stem-cell transplantation (HSCT) to treat patients with relapsed or refractory CD7-positive leukemia and lymphoma.1\n\n\n\nRelapsed or refractory hematologic cancers typically have a dire prognosis, with traditional treatments often leading to a 5-year overall survival of less than 20%. Toxicities from pretransplant conditioning and graft-vs-host disease (GVHD) prophylaxis have limited the integration of CAR T-cell therapy as a bridge to allogeneic HSCT.2 This all-in-one strategy avoids traditional pharmacologic myeloablation and GVHD prophylaxis and has shown promising results for patients with limited therapeutic options.\n\n\n\nThe researchers noted, \"Our findings suggest that sequential CD7 CAR T-cell therapy and haploidentical HSCT is safe and effective, with remission and serious but reversible adverse events. This strategy offers a feasible approach for patients with CD7-positive tumors who are ineligible for conventional allogeneic HSCT.\"\n\n\n\n\n\nThe study, completed at the Bone Marrow Transplantation Center at Zhejiang University School of Medicine, involved 10 patients who underwent sequential therapy, including 7 with acute myeloid leukemia, 2 with T-cell acute lymphoblastic leukemia, and 1 with T-cell lymphoblastic lymphoma (grade IVa). These patients had previously shown poor responses to conventional treatments, completing a median of 9.5 (range, 4-15) therapy courses.\n\n\n\nUndergoing sequential therapy, starting with CD7 CAR T-cell therapy followed by haploidentical HSCT, all patients achieved complete remission, albeit with incomplete hematologic recovery. At 1 year post treatment, the overall survival rate was 68% (95% CI, 43%-100%), and the disease-free survival rate was 54% (95% CI, 29%-100%). The absence of pharmacologic myeloablation and GVHD prophylaxis drugs, relying instead on the immunosuppressive effects of the CAR T cells, presents a less toxic and potentially more effective treatment method.\n\n\n\nSerious but reversible adverse events were reported, including grade 4 pancytopenia observed in all patients following CAR T-cell therapy, which was expected due to the therapy's mechanism. Following HSCT, 1 patient died from septic shock and another from encephalitis, highlighting the treatment's significant risks. Additionally, 3 patients developed grade 2 HSCT-associated acute GVHD. The median follow-up was 15.1 (range, 3.1-24.0) months after CAR T-cell therapy. Six patients remained in minimal residual disease–negative complete remission during the follow-up period.\n\n\n\nThe researchers acknowledged the limitations of their study, including its small sample size and the exploratory nature of the treatment.\n\n\n\nThey noted that \"because we were evaluating a new therapeutic strategy, the findings of this study still need to be extended and confirmed in a larger and more homogeneous cohort of patients.\"\n\n\n\nAlthough the results of the study are promising, the authors acknowledge the need for larger, more definitive trials to confirm these results and potentially expand the therapy's application.\n\n\n\nReferences\n\n1. Hu Y, Zhang M, Yang T, et al. Sequential CD7 CAR T-cell therapy and allogeneic HSCT without GVHD prophylaxis. N Engl J Med. 2024;390(16):1467-1480. doi:10.1056/NEJMoa2313812\n\n2. Ellard R, Kenyon M, Hutt D, et al. The EBMT immune effector cell nursing guidelines on CAR-T therapy: a framework for patient care and managing common toxicities. Clin Hematol Int. 2022;4(3):75-88. doi:10.1007/s44228-022-00004-8","description":"This study introduces a novel \"all-in-one\" strategy combining CD7 chimeric antigen receptor T-cell therapy with haploidentical hematopoietic stem-cell transplantation, showing significant potential to improve survival and reduce toxicities in patients with relapsed or refractory CD7-positive hematologic cancers.\n","author":[{"@type":"Person","name":"Kimberly Rath, PharmD"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27300%27%20height=%2744%27/%3e"/></span><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" srcSet="/_next/image?url=%2Fan_mjhls_brand_ko.png&w=384&q=75 1x, /_next/image?url=%2Fan_mjhls_brand_ko.png&w=640&q=75 2x" src="/_next/image?url=%2Fan_mjhls_brand_ko.png&w=640&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" loading="lazy"/></noscript></span></div><div class="flex"><div class="flex justify-between pt-6"><div class="w-[40%]"><div class="text-footer-text-color text-xs"><p>2 Commerce Drive<br/>Suite 100<br/>Cranbury, NJ 08512</p></div><div class="self-start py-6" style="display:flex;flex-wrap:wrap"><a rel="noreferrer noopener" class="pr-1" target="_blank" href="https://www.facebook.com/TheAmericanJournalOfManagedCare"><p> <svg width='25px' height='25px' viewBox='0 0 512 512' version='1.1' xmlns='http://www.w3.org/2000/svg'> <g id='Page-1' stroke='none' strokeWidth='1' fill='none' fillRule='evenodd'> <g id='facebook' fill='#FFFFFF' fillRule='nonzero'> <path d='M512,256 C512,114.6 397.4,0 256,0 C114.6,0 0,114.6 0,256 C0,397.4 114.6,512 256,512 C257.5,512 259,512 260.5,511.9 L260.5,312.7 L205.5,312.7 L205.5,248.6 L260.5,248.6 L260.5,201.4 C260.5,146.7 293.9,116.9 342.7,116.9 C366.1,116.9 386.2,118.6 392,119.4 L392,176.6 L358.4,176.6 C331.9,176.6 326.7,189.2 326.7,207.7 L326.7,248.5 L390.2,248.5 L381.9,312.6 L326.7,312.6 L326.7,502.1 C433.7,471.4 512,372.9 512,256 Z' id='Path' /> </g> </g> </svg> </p></a><a rel="noreferrer noopener" class="pr-1" href="https://twitter.com/AJMC_Journal"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" width="25" height="25" viewBox="1.41 1.41 252.9 252.9"><g transform="translate(1.4065934065934016 1.4065934065934016) scale(2.81 2.81)"><polygon points="24.89,23.01 57.79,66.99 65.24,66.99 32.34,23.01" fill="#FFFFFF" transform="matrix(1 0 0 1 0 0)"></polygon><path d="M 45 0 L 45 0 C 20.147 0 0 20.147 0 45 v 0 c 0 24.853 20.147 45 45 45 h 0 c 24.853 0 45 -20.147 45 -45 v 0 C 90 20.147 69.853 0 45 0 z M 56.032 70.504 L 41.054 50.477 L 22.516 70.504 h -4.765 L 38.925 47.63 L 17.884 19.496 h 16.217 L 47.895 37.94 l 17.072 -18.444 h 4.765 L 50.024 40.788 l 22.225 29.716 H 56.032 z" fill="#FFFFFF" transform="matrix(1 0 0 1 0 0)" stroke-linecap="round"></path></g></svg></a><a rel="noreferrer noopener" class="pr-1" target="_blank" href="https://www.linkedin.com/company/american-journal-of-managed-care/"><p> <svg width='25px' height='25px' viewBox='0 0 512 512' version='1.1' xmlns='http://www.w3.org/2000/svg'> <g id='Page-1' stroke='none' strokeWidth='1' fill='none' fillRule='evenodd'> <g id='linkedin' fill='#FFFFFF' fillRule='nonzero'> <path d='M256,0 C114.636719,0 0,114.636719 0,256 C0,397.363281 114.636719,512 256,512 C397.363281,512 512,397.363281 512,256 C512,114.636719 397.363281,0 256,0 Z M181.609375,387 L119.261719,387 L119.261719,199.425781 L181.609375,199.425781 L181.609375,387 Z M150.4375,173.8125 L150.03125,173.8125 C129.109375,173.8125 115.578125,159.410156 115.578125,141.410156 C115.578125,123.003906 129.523438,109 150.851562,109 C172.179688,109 185.304688,123.003906 185.710938,141.410156 C185.710938,159.410156 172.179688,173.8125 150.4375,173.8125 Z M406.421875,387 L344.082031,387 L344.082031,286.652344 C344.082031,261.433594 335.054688,244.234375 312.496094,244.234375 C295.273438,244.234375 285.015625,255.835938 280.507812,267.035156 C278.859375,271.042969 278.457031,276.644531 278.457031,282.25 L278.457031,387 L216.113281,387 C216.113281,387 216.929688,217.023438 216.113281,199.425781 L278.457031,199.425781 L278.457031,225.984375 C286.742188,213.203125 301.566406,195.023438 334.644531,195.023438 C375.664062,195.023438 406.421875,221.832031 406.421875,279.445312 L406.421875,387 Z' id='Shape' /> </g> </g> </svg> </p></a><a rel="noreferrer noopener" class="pr-1" target="_blank" href="https://www.instagram.com/ajmcjournal/"><p> <svg width='25px' height='25px' viewBox='0 0 512 512' version='1.1' xmlns='http://www.w3.org/2000/svg'> <g id='Page-1' stroke='none' strokeWidth='1' fill='none' fillRule='evenodd'> <g id='instagram' fill='#FFFFFF' fillRule='nonzero'> <path d='M305,256 C305,283.0625 283.0625,305 256,305 C228.9375,305 207,283.0625 207,256 C207,228.9375 228.9375,207 256,207 C283.0625,207 305,228.9375 305,256 Z' id='Path' /> <path d='M370.59375,169.304688 C368.238281,162.921875 364.480469,157.144531 359.597656,152.402344 C354.855469,147.519531 349.082031,143.761719 342.695312,141.40625 C337.515625,139.394531 329.734375,137 315.402344,136.347656 C299.898438,135.640625 295.25,135.488281 256,135.488281 C216.746094,135.488281 212.097656,135.636719 196.597656,136.34375 C182.265625,137 174.480469,139.394531 169.304688,141.40625 C162.917969,143.761719 157.140625,147.519531 152.402344,152.402344 C147.519531,157.144531 143.761719,162.917969 141.402344,169.304688 C139.390625,174.484375 136.996094,182.269531 136.34375,196.601562 C135.636719,212.101562 135.484375,216.75 135.484375,256.003906 C135.484375,295.253906 135.636719,299.902344 136.34375,315.40625 C136.996094,329.738281 139.390625,337.519531 141.402344,342.699219 C143.761719,349.085938 147.515625,354.859375 152.398438,359.601562 C157.140625,364.484375 162.914062,368.242188 169.300781,370.597656 C174.480469,372.613281 182.265625,375.007812 196.597656,375.660156 C212.097656,376.367188 216.742188,376.515625 255.996094,376.515625 C295.253906,376.515625 299.902344,376.367188 315.398438,375.660156 C329.730469,375.007812 337.515625,372.613281 342.695312,370.597656 C355.515625,365.652344 365.648438,355.519531 370.59375,342.699219 C372.605469,337.519531 375,329.738281 375.65625,315.40625 C376.363281,299.902344 376.511719,295.253906 376.511719,256.003906 C376.511719,216.75 376.363281,212.101562 375.65625,196.601562 C375.003906,182.269531 372.609375,174.484375 370.59375,169.304688 L370.59375,169.304688 Z M256,331.484375 C214.308594,331.484375 180.511719,297.691406 180.511719,256 C180.511719,214.308594 214.308594,180.515625 256,180.515625 C297.6875,180.515625 331.484375,214.308594 331.484375,256 C331.484375,297.691406 297.6875,331.484375 256,331.484375 Z M334.46875,195.171875 C324.726562,195.171875 316.828125,187.273438 316.828125,177.53125 C316.828125,167.789062 324.726562,159.890625 334.46875,159.890625 C344.210938,159.890625 352.109375,167.789062 352.109375,177.53125 C352.105469,187.273438 344.210938,195.171875 334.46875,195.171875 Z' id='Shape' /> <path d='M256,0 C114.636719,0 0,114.636719 0,256 C0,397.363281 114.636719,512 256,512 C397.363281,512 512,397.363281 512,256 C512,114.636719 397.363281,0 256,0 Z M402.113281,316.605469 C401.402344,332.253906 398.914062,342.9375 395.28125,352.289062 C387.644531,372.035156 372.035156,387.644531 352.289062,395.28125 C342.941406,398.914062 332.253906,401.398438 316.609375,402.113281 C300.933594,402.828125 295.925781,403 256.003906,403 C216.078125,403 211.074219,402.828125 195.394531,402.113281 C179.75,401.398438 169.0625,398.914062 159.714844,395.28125 C149.902344,391.589844 141.019531,385.804688 133.675781,378.324219 C126.199219,370.984375 120.414062,362.097656 116.722656,352.289062 C113.089844,342.941406 110.601562,332.253906 109.890625,316.609375 C109.167969,300.929688 109,295.921875 109,256 C109,216.078125 109.167969,211.070312 109.886719,195.394531 C110.597656,179.746094 113.082031,169.0625 116.714844,159.710938 C120.40625,149.902344 126.195312,141.015625 133.675781,133.675781 C141.015625,126.195312 149.902344,120.410156 159.710938,116.71875 C169.0625,113.085938 179.746094,110.601562 195.394531,109.886719 C211.070312,109.171875 216.078125,109 256,109 C295.921875,109 300.929688,109.171875 316.605469,109.890625 C332.253906,110.601562 342.9375,113.085938 352.289062,116.714844 C362.097656,120.40625 370.984375,126.195312 378.328125,133.675781 C385.804688,141.019531 391.59375,149.902344 395.28125,159.710938 C398.917969,169.0625 401.402344,179.746094 402.117188,195.394531 C402.832031,211.070312 403,216.078125 403,256 C403,295.921875 402.832031,300.929688 402.113281,316.605469 L402.113281,316.605469 Z' id='Shape' /> </g> </g> </svg> </p></a><a rel="noreferrer noopener" class="pr-1" target="_blank" href="/rss"><p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:svgjs="http://svgjs.com/svgjs" version="1.1" width="25px" height="25px" x="0" y="0" viewBox="0 0 512 512" style="enable-background:new 0 0 512 512" xml:space="preserve"> <g> <path xmlns="http://www.w3.org/2000/svg" d="m437.019531 74.980469c-48.351562-48.351563-112.640625-74.980469-181.019531-74.980469s-132.667969 26.628906-181.019531 74.980469c-48.351563 48.351562-74.980469 112.640625-74.980469 181.019531s26.628906 132.667969 74.980469 181.019531c48.351562 48.351563 112.640625 74.980469 181.019531 74.980469s132.667969-26.628906 181.019531-74.980469c48.351563-48.351562 74.980469-112.640625 74.980469-181.019531s-26.628906-132.667969-74.980469-181.019531zm-267.757812 292.957031c-13.730469 0-24.90625-11.171875-24.90625-24.90625s11.175781-24.90625 24.90625-24.90625c13.734375 0 24.90625 11.171875 24.90625 24.90625s-11.171875 24.90625-24.90625 24.90625zm80.277343 4.925781c-8.28125 0-15-6.714843-15-15 0-44.171875-35.9375-80.109375-80.109374-80.109375-8.285157 0-15-6.71875-15-15 0-8.285156 6.714843-15 15-15 60.714843 0 110.109374 49.394532 110.109374 110.109375 0 8.285157-6.714843 15-15 15zm67.09375 0c-8.285156 0-15-6.714843-15-15 0-81.167969-66.035156-147.203125-147.203124-147.203125-8.285157 0-15-6.714844-15-15s6.714843-15 15-15c97.710937 0 177.203124 79.492188 177.203124 177.203125 0 8.285157-6.714843 15-15 15zm66.292969 0c-8.28125 0-15-6.714843-15-15 0-117.722656-95.773437-213.496093-213.496093-213.496093-8.285157 0-15-6.714844-15-15 0-8.285157 6.714843-15 15-15 65.039062 0 126.1875 25.328124 172.179687 71.316406 45.988281 45.992187 71.316406 107.140625 71.316406 172.179687 0 8.285157-6.714843 15-15 15zm0 0" fill="#ffffff" data-original="#000000" style=""/> </g> </svg></p></a></div><div class="text-footer-text-color text-xs"><p>© 2024 MJH Life Sciences<sup>®</sup> and AJMC®.<br/> All rights reserved.</p></div></div><div class="flex flex-row flex-wrap self-start w-[60%]"><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_self" href="/about-us">About</a></div><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_self" href="/contactus">Contact</a></div><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_self" href="/editorial-boards">Editorial Boards</a></div><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_self" href="/advertise">Advertise</a></div><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_blank" href="https://www.mjhlifesciences.com/ccpa?domain=www.ajmc.com">Do Not Sell My Information</a></div><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_self" href="/terms">Terms & Conditions</a></div><div class="w-[50%] pb-3 px-2 my-0 cursor-pointer text-footer-text-color hover:text-footer-text-color/80 hover:underline"><a class="text-md" target="_self" href="/privacy">Privacy Policy</a></div></div><div class="flex items-start mr-6 lg:mr-10"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27251%27%20height=%2768%27/%3e"/></span><img alt="AJMC Managed Markets Network Logo" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="AJMC Managed Markets Network Logo" srcSet="/_next/image?url=%2FAJMC_MMN_logo_light.png&w=256&q=75 1x, /_next/image?url=%2FAJMC_MMN_logo_light.png&w=640&q=75 2x" src="/_next/image?url=%2FAJMC_MMN_logo_light.png&w=640&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" loading="lazy"/></noscript></span></div></div></div></div></div><div class="w-[30%] bg-[#003767] flex items-center justify-center "><div class="flex flex-col justify-between "><a target="_self" rel="noopener noreferrer" class="my-2 px-8" href="/topic/center-on-health-equity-and-access"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27315%27%20height=%2777%27/%3e"/></span><img alt="CH Logo" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="CH Logo" srcSet="/_next/image?url=%2FCHA_Logo.png&w=384&q=75 1x, /_next/image?url=%2FCHA_Logo.png&w=640&q=75 2x" src="/_next/image?url=%2FCHA_Logo.png&w=640&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" loading="lazy"/></noscript></span></a><a target="_blank" rel="noopener noreferrer" class="my-2 px-8" href="https://www.centerforbiosimilars.com/"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27315%27%20height=%2777%27/%3e"/></span><img alt="Center for Biosimilars Logo" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Center for Biosimilars Logo" srcSet="/_next/image?url=%2FCB.png&w=384&q=75 1x, /_next/image?url=%2FCB.png&w=640&q=75 2x" src="/_next/image?url=%2FCB.png&w=640&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" loading="lazy"/></noscript></span></a></div></div></div></div></div><script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"pageProps":{},"cache":{"main_menu":[{"is_active":true,"sortOrder":1,"_rev":"Yw6MEKZDMdk6hC2JCRdGN7","_type":"mainNavigation","name":"News","_updatedAt":"2020-04-14T13:26:21Z","_id":"e8c503ba-34b9-43d5-8ce1-e8603c4e4b6b","_createdAt":"2020-04-14T13:26:14Z","navParent":null,"subQuery":[{"url":"/news","is_active":true,"children":[],"navParent":{"_ref":"e8c503ba-34b9-43d5-8ce1-e8603c4e4b6b","_type":"reference"},"_updatedAt":"2020-04-14T13:30:35Z","_createdAt":"2020-04-14T13:30:35Z","_type":"mainNavigation","_id":"1376963d-32e8-4647-bb5e-59c984e35893","_rev":"sBk7YzjWMuBuhiatU3YIhQ","name":"All News"},{"_type":"mainNavigation","_id":"2af5da5e-78c2-42c8-90b8-3900f8c89889","navParent":{"_ref":"e8c503ba-34b9-43d5-8ce1-e8603c4e4b6b","_type":"reference"},"url":"/press-release","children":[],"is_active":true,"_rev":"QxOJBWa4XErmibN6Cb5OcA","name":"Press Releases","_updatedAt":"2020-04-14T13:30:57Z","_createdAt":"2020-04-14T13:30:57Z"},{"_id":"854a1ad1-9831-4387-bda9-ffb93a074ace","_createdAt":"2021-07-29T12:15:49Z","_updatedAt":"2022-01-07T20:44:44Z","children":[],"url":"/approvals-launches","is_active":true,"_rev":"jvOgZ3KZdbRHfWlt9ePmOA","_type":"mainNavigation","navParent":{"_ref":"e8c503ba-34b9-43d5-8ce1-e8603c4e4b6b","_type":"reference"},"name":"Product Approvals and Launches"}]},{"is_active":true,"_createdAt":"2020-04-14T13:26:30Z","_type":"mainNavigation","name":"Video","subQuery":[{"_updatedAt":"2024-05-24T16:52:54Z","children":[],"_type":"mainNavigation","name":"All Video Types","url":"/video-hub","_rev":"rcwwj6TiN2Q0ymhqDzJ8ty","_id":"f51d85fa-cabc-4c7d-85d0-11301088b7f6","is_active":true,"navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"_createdAt":"2024-05-24T16:37:06Z","sortOrder":1},{"navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"name":"AJMC TV","_updatedAt":"2024-05-28T19:38:54Z","_type":"mainNavigation","_id":"a99a3683-5173-46b3-94b0-21b7d6b06a24","url":"/interviews","children":[],"is_active":true,"_createdAt":"2024-05-24T16:38:14Z","_rev":"LJrwYxwtzLC9JsOYMk8TBr"},{"is_active":true,"_createdAt":"2020-04-14T13:43:45Z","_type":"mainNavigation","name":"Insights","url":"/insights","children":[],"_id":"b03ccbf6-6387-48de-8edc-4f1f23debe40","navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"_rev":"Yw6MEKZDMdk6hC2JCRda8Z","_updatedAt":"2020-04-14T13:43:45Z"},{"_type":"mainNavigation","name":"OnLocation","_id":"f3d69d10-636b-4927-8ff4-4f54fabc940a","navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"url":"/onlocation","is_active":true,"_rev":"k6N5FycA5UhVnvpzSEa3Rp","_updatedAt":"2020-04-14T13:44:19Z","_createdAt":"2020-04-14T13:44:19Z","children":[]},{"is_active":true,"navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"_id":"d4e3d69c-8a07-4191-af89-27d7e838af08","url":"/payer-perspectives","children":[],"_createdAt":"2022-10-05T15:29:11Z","_rev":"37PW14Mg02p9z7FTF1SGE9","_type":"mainNavigation","name":"Payer Perspectives","_updatedAt":"2022-10-05T15:29:11Z"},{"_createdAt":"2020-04-14T13:44:43Z","is_active":true,"navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"_type":"mainNavigation","url":"/peer-exchange","children":[],"name":"Peer Exchange","_updatedAt":"2020-04-14T13:44:43Z","_rev":"VdTcsTJkAuZveXGf2i9Pes","_id":"8f602f1e-1840-4c32-8cdb-9a26d6c0e873"},{"is_active":true,"_updatedAt":"2024-05-24T18:27:43Z","name":"Post Conference Perspectives","_id":"0f532685-cd4c-4350-89cd-b8a388e6495b","navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"_createdAt":"2024-05-24T18:27:43Z","_rev":"Jz2W7keLhiw1UYkGHgA51N","_type":"mainNavigation","url":"/post-conference-perspectives","children":[]},{"is_active":true,"_type":"mainNavigation","children":[],"_rev":"y3lsbm3yQTliOnC9CU5TiR","url":"/stakeholder-summit","name":"Stakeholder Summit","_id":"bbc55ff8-1532-475e-9f51-f9d5eb39e369","_updatedAt":"2020-12-01T22:43:26Z","navParent":{"_ref":"821e259a-db55-4862-985a-5cd089bbf894","_type":"reference"},"_createdAt":"2020-12-01T22:43:10Z"}],"_id":"821e259a-db55-4862-985a-5cd089bbf894","_updatedAt":"2024-05-24T16:36:15Z","sortOrder":2,"_rev":"rcwwj6TiN2Q0ymhqDzIFjO","navParent":null},{"sortOrder":3,"navParent":null,"subQuery":[],"_rev":"rcwwj6TiN2Q0ymhqDzIUb7","name":"Podcasts","_updatedAt":"2024-05-24T16:41:18Z","_createdAt":"2024-05-24T16:40:58Z","is_active":true,"_type":"mainNavigation","_id":"4939ee15-ae6f-4aba-8481-9ee27ce729d3","url":"/podcasts"},{"_createdAt":"2020-04-14T13:27:01Z","sortOrder":4,"_rev":"rcwwj6TiN2Q0ymhqDzIVAU","name":"Conferences","_id":"6841664a-93f2-4f56-8760-836ec9c7b483","is_active":true,"_type":"mainNavigation","navParent":null,"subQuery":[{"children":[],"_createdAt":"2020-06-12T15:17:29Z","_type":"mainNavigation","_updatedAt":"2020-08-21T22:11:23Z","is_active":true,"navParent":{"_type":"reference","_ref":"6841664a-93f2-4f56-8760-836ec9c7b483"},"_rev":"pI9SawGKsTP14Lioy589Kx","name":"Conference Coverage","_id":"f45b532b-23e3-4b44-8d7f-2f3c13c9ae81","url":"/latest-conference","sortOrder":1},{"children":[],"is_active":true,"_id":"004461ae-46cb-45ef-916e-f03c6d99d6d3","navParent":{"_ref":"6841664a-93f2-4f56-8760-836ec9c7b483","_type":"reference"},"sortOrder":2,"_updatedAt":"2020-06-12T15:19:26Z","_rev":"FxFuWbqTkFGbPWgBBSR6xp","_createdAt":"2020-06-12T15:18:28Z","_type":"mainNavigation","name":"Conference Listing","url":"/conference"},{"_type":"mainNavigation","_id":"a006d0df-0cc9-4386-abfb-b1931a3918d4","_createdAt":"2024-07-03T19:00:13Z","_rev":"ZU3dXbR1BZtBbbPuRGxz53","navParent":{"_ref":"6841664a-93f2-4f56-8760-836ec9c7b483","_type":"reference"},"_updatedAt":"2024-07-03T19:00:13Z","url":"/post-conference-perspectives","is_active":true,"sortOrder":3,"name":"Post Conference Perspectives","children":[]}],"_updatedAt":"2024-05-24T16:41:40Z"},{"_updatedAt":"2024-05-24T16:41:49Z","is_active":true,"_rev":"uJbbwQWkLESsncBrcLL0hr","_type":"mainNavigation","name":"Journals","navParent":null,"subQuery":[{"is_active":true,"url":"/publications","_rev":"rcwwj6TiN2Q0ymhqDzIVyQ","_updatedAt":"2024-05-24T16:42:23Z","sortOrder":1,"_type":"mainNavigation","_id":"48193abd-ecf4-4c90-b0ae-984ca2be88c9","children":[],"navParent":{"_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150","_type":"reference"},"_createdAt":"2020-05-04T21:06:00Z","name":"All Journals"},{"_updatedAt":"2024-05-24T16:42:39Z","_type":"mainNavigation","url":"/publications/issue","sortOrder":2,"_createdAt":"2020-04-14T13:55:29Z","_rev":"rcwwj6TiN2Q0ymhqDzIWug","name":"The American Journal of Managed Care","_id":"08081ddf-ffd8-4b17-a2ff-dfe6a0ac64a3","children":[],"is_active":true,"navParent":{"_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150","_type":"reference"}},{"_type":"mainNavigation","name":"Population Health, Equity \u0026 Outcomes","url":"/publications/ajac","is_active":true,"navParent":{"_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150","_type":"reference"},"_rev":"4fso9RuTzczLhlxmnMQ1bu","sortOrder":3,"_createdAt":"2020-04-14T13:56:01Z","_id":"47782239-2714-4bd1-99e6-750443bd39ea","_updatedAt":"2024-09-16T13:23:11Z","children":[]},{"_id":"b99cc54f-5801-46e9-bd20-e690623ed12c","children":[],"navParent":{"_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150","_type":"reference"},"url":"/publications/evidence-based-oncology","_updatedAt":"2024-05-24T16:43:12Z","_type":"mainNavigation","name":"Evidence-Based Oncology","is_active":true,"sortOrder":4,"_createdAt":"2020-04-14T13:56:21Z","_rev":"uJbbwQWkLESsncBrcLL4uf"},{"_updatedAt":"2024-05-24T16:43:26Z","url":"/supplement","is_active":true,"sortOrder":5,"_rev":"rcwwj6TiN2Q0ymhqDzIY1L","children":[],"_type":"mainNavigation","name":"About Supplements and Featured Publications","_createdAt":"2024-05-23T20:59:41Z","_id":"6e7e3485-ef8b-40e3-8320-3c434df6bbb5","navParent":{"_type":"reference","_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150"}},{"name":"Supplements and Featured Publications Issues","_updatedAt":"2024-05-24T16:43:32Z","_type":"mainNavigation","children":[],"sortOrder":6,"is_active":true,"_createdAt":"2020-04-14T13:56:51Z","_id":"a2112c87-8e92-4b64-b42d-3117117f67a3","url":"/publications/supplement","navParent":{"_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150","_type":"reference"},"_rev":"uJbbwQWkLESsncBrcLL5w0"},{"_rev":"rcwwj6TiN2Q0ymhqDzIYDp","_type":"mainNavigation","name":"Submit a Manuscript","navParent":{"_ref":"94f13109-c3cc-47b5-bf49-96ed727c8150","_type":"reference"},"_createdAt":"2023-03-14T13:29:11Z","sortOrder":7,"url":"/submit-a-manuscript","_id":"fa8c9edc-3d32-4e9e-b68b-47d5c15694a5","_updatedAt":"2024-05-24T16:43:38Z","is_active":true,"children":[]}],"_createdAt":"2020-04-14T13:27:20Z","sortOrder":5,"_id":"94f13109-c3cc-47b5-bf49-96ed727c8150"},{"is_active":true,"sortOrder":6,"_type":"mainNavigation","name":"Events","_id":"ad5c19be-040c-4ea8-b639-807f54c9a1aa","navParent":null,"subQuery":[{"is_active":true,"_createdAt":"2024-05-24T16:44:43Z","name":"Institute for Value-Based Medicine","_rev":"Jz2W7keLhiw1UYkGHgA4Yf","navParent":{"_ref":"ad5c19be-040c-4ea8-b639-807f54c9a1aa","_type":"reference"},"_type":"mainNavigation","_id":"de4fe195-3db9-4d12-842d-f26100fbea5b","_updatedAt":"2024-05-24T18:26:23Z","url":"/ivbmevents","children":[]},{"url":"https://pcoc.ajmc.com/","_rev":"Jz2W7keLhiw1UYkGHgA4eP","children":[],"_createdAt":"2024-05-24T16:45:02Z","_updatedAt":"2024-05-24T18:26:42Z","navParent":{"_ref":"ad5c19be-040c-4ea8-b639-807f54c9a1aa","_type":"reference"},"_type":"mainNavigation","_id":"dddfc37d-8958-4e0a-91e3-0634bb6502a3","is_active":true,"name":"Patient-Centered Oncology Care"}],"_createdAt":"2020-04-14T13:27:17Z","_rev":"8ZvheBjSwe5Dc4gCmgsR0M","url":"/events","_updatedAt":"2020-05-08T20:03:10Z"},{"subQuery":[{"url":"/interactive-tools","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDzIfXP","_id":"4a08b5fc-379c-4952-bec1-0d9dacb11170","_updatedAt":"2024-05-24T16:46:13Z","sortOrder":1,"navParent":{"_ref":"86b03e38-f3d2-41d1-89e7-c3175c571a55","_type":"reference"},"children":[],"_type":"mainNavigation","name":"Interactive Tools","_createdAt":"2020-04-14T13:51:39Z"},{"_type":"mainNavigation","children":[],"navParent":{"_ref":"86b03e38-f3d2-41d1-89e7-c3175c571a55","_type":"reference"},"_createdAt":"2020-10-16T13:03:47Z","_rev":"rcwwj6TiN2Q0ymhqDyFVrf","name":"Clinical Spotlight","_id":"43960f88-0c8d-404b-b9d9-d90432c2c516","url":"/clinical-spotlight","_updatedAt":"2024-05-23T20:32:07Z","is_active":true},{"_updatedAt":"2024-05-24T16:46:44Z","url":"/custom-email","navParent":{"_ref":"86b03e38-f3d2-41d1-89e7-c3175c571a55","_type":"reference"},"is_active":true,"_id":"38aa3af0-8a34-4ae6-898c-37214580d384","name":"Microsites","_createdAt":"2024-05-24T16:46:44Z","_rev":"rcwwj6TiN2Q0ymhqDzIhDR","children":[],"_type":"mainNavigation"},{"url":"/sponsored","navParent":{"_ref":"86b03e38-f3d2-41d1-89e7-c3175c571a55","_type":"reference"},"_createdAt":"2024-05-24T16:47:05Z","_id":"d0b0683f-18e1-4e75-89fd-fb4e578a562f","children":[],"_updatedAt":"2024-05-24T16:47:05Z","_rev":"rcwwj6TiN2Q0ymhqDzIiDr","_type":"mainNavigation","name":"Sponsored Content","is_active":true}],"name":"Resources","_id":"86b03e38-f3d2-41d1-89e7-c3175c571a55","_updatedAt":"2024-05-24T16:45:37Z","is_active":true,"navParent":null,"_createdAt":"2020-04-14T13:29:34Z","sortOrder":7,"_rev":"rcwwj6TiN2Q0ymhqDzIdco","_type":"mainNavigation"},{"sortOrder":8,"subQuery":[],"_updatedAt":"2024-08-27T15:31:04Z","_createdAt":"2020-04-14T14:00:08Z","_rev":"LtkInV1jlQdtEIFjVpi9sG","is_active":true,"navParent":null,"name":"CE","_id":"621fccf5-dcdb-40a9-af70-9bf3ccf79278","url":"/continuing-education","_type":"mainNavigation"},{"sortOrder":9,"_type":"mainNavigation","navParent":null,"subQuery":[{"is_active":true,"_rev":"Jz2W7keLhiw1UYkGHgBp6D","name":"AJMC Staff","_id":"be637b3b-f72a-4049-91b8-409809b2d815","_updatedAt":"2024-05-24T19:05:57Z","url":"/editorial","_createdAt":"2024-05-24T19:05:57Z","_type":"mainNavigation","navParent":{"_ref":"c14e4637-909c-4bf6-bf81-64eeb6005352","_type":"reference"},"children":[]},{"name":"Anniversary","_id":"5298152f-5135-4c2c-a46e-a14ad0300bf4","_updatedAt":"2024-05-24T16:48:30Z","url":"/anniversary","navParent":{"_ref":"c14e4637-909c-4bf6-bf81-64eeb6005352","_type":"reference"},"_createdAt":"2024-05-24T16:48:30Z","_type":"mainNavigation","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDzIn5Y","children":[]},{"_id":"28d33143-d9a9-45bd-af63-bed8d2198118","_updatedAt":"2024-07-23T13:38:48Z","url":"/about/seema-sonnad-nomination","name":"Seema Sonnad Award","children":[],"_createdAt":"2024-05-24T18:24:23Z","is_active":true,"navParent":{"_ref":"c14e4637-909c-4bf6-bf81-64eeb6005352","_type":"reference"},"_type":"mainNavigation","_rev":"AGf4LvcO2r7q1La1cjR7dD"},{"_createdAt":"2024-05-24T16:49:00Z","_id":"acb7dc53-dfab-462a-b2e9-b0cfc8675da4","_rev":"uJbbwQWkLESsncBrcLLVEZ","_type":"mainNavigation","_updatedAt":"2024-05-24T16:49:00Z","is_active":true,"children":[],"url":"/partners","navParent":{"_ref":"c14e4637-909c-4bf6-bf81-64eeb6005352","_type":"reference"},"name":"Strategic Alliance Partners"}],"_id":"c14e4637-909c-4bf6-bf81-64eeb6005352","_createdAt":"2024-05-24T16:48:11Z","_rev":"rcwwj6TiN2Q0ymhqDzIlc0","name":"About AJMC","_updatedAt":"2024-05-24T16:48:11Z","is_active":true},{"sortOrder":9,"name":"Subscribe","blank":true,"is_active":true,"_createdAt":"2020-06-22T20:56:33Z","subQuery":[],"_type":"mainNavigation","_updatedAt":"2024-03-11T14:58:15Z","_rev":"gFXie0Ldruy1o91XppbLLd","_id":"1e279576-0b33-4e57-8782-b6b1edbf68da","url":"https://one.ajmc.com/subscribe","navParent":null}],"sub_menu":[{"_rev":"Jz2W7keLhiw1UYkGHfbRHa","_id":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_updatedAt":"2024-05-24T05:08:37Z","subQuery":[{"_createdAt":"2024-05-24T05:06:44Z","is_active":true,"navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"_id":"aa3904f3-c0d8-495d-a77f-afcc41f27045","children":[],"_type":"subNavigation","_updatedAt":"2024-05-24T05:06:44Z","url":"/compendium/biosimilars","_rev":"Jz2W7keLhiw1UYkGHfbM3A","name":"Biosimilars"},{"_updatedAt":"2024-06-11T20:17:38Z","children":[{"url":"/compendium/cardiovascular","is_active":true,"navParent":{"_type":"reference","_ref":"6c47e32a-ae7f-4f3a-92e2-c99d54ae28ab"},"_type":"subNavigation","name":"Cardiovascular","_updatedAt":"2024-05-24T05:30:54Z","_createdAt":"2024-05-24T05:30:54Z","_rev":"Jz2W7keLhiw1UYkGHfbquf","_id":"c3566f20-e7c6-4b38-bf9f-7d52055698b1"},{"is_active":true,"_createdAt":"2024-05-24T05:32:42Z","_rev":"Jz2W7keLhiw1UYkGHfbumO","navParent":{"_ref":"6c47e32a-ae7f-4f3a-92e2-c99d54ae28ab","_type":"reference"},"_type":"subNavigation","name":"Chronic Kidney Disease","_id":"f3a69e16-dc38-4135-886e-d70e18532bf4","_updatedAt":"2024-05-24T05:32:42Z","url":"/compendium/ckd"},{"is_active":true,"_createdAt":"2024-05-24T05:31:14Z","_type":"subNavigation","name":"Diabetes","navParent":{"_ref":"6c47e32a-ae7f-4f3a-92e2-c99d54ae28ab","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfbrEl","_id":"79c02dc8-3c2d-451b-9797-008b25d61d4d","_updatedAt":"2024-05-24T05:31:14Z","url":"/compendium/diabetes"},{"url":"/compendium/heart-failure","navParent":{"_ref":"6c47e32a-ae7f-4f3a-92e2-c99d54ae28ab","_type":"reference"},"_createdAt":"2024-05-24T05:31:38Z","_rev":"Jz2W7keLhiw1UYkGHfbrQF","name":"Heart Failure","_id":"84c7dd54-fb21-4bc5-86bc-9bbf39a7f836","_updatedAt":"2024-05-24T05:31:38Z","is_active":true,"_type":"subNavigation"},{"is_active":true,"_rev":"Jz2W7keLhiw1UYkGHfbsbS","name":"Type 1 Diabetes","_id":"aadd9bdc-4dd1-4ac1-be4f-2afb4315b6cb","_updatedAt":"2024-05-24T05:32:00Z","navParent":{"_ref":"6c47e32a-ae7f-4f3a-92e2-c99d54ae28ab","_type":"reference"},"_createdAt":"2024-05-24T05:32:00Z","_type":"subNavigation","url":"/compendium/type1diabetes"}],"is_active":true,"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_createdAt":"2024-05-24T05:30:27Z","_rev":"G7uWgc8ggxb5zBvm8zNQqB","_type":"subNavigation","name":"Cardiorenalmetabolic","_id":"6c47e32a-ae7f-4f3a-92e2-c99d54ae28ab"},{"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"name":"Dermatology","children":[{"_createdAt":"2024-05-23T21:42:49Z","name":"Alopecia","is_active":true,"navParent":{"_type":"reference","_ref":"7599f50b-36ff-42a5-8d72-82814db9b988"},"_rev":"Jz2W7keLhiw1UYkGHfbTPe","_type":"subNavigation","_id":"04523862-a8a1-4626-b288-95b3d4114267","_updatedAt":"2024-05-24T05:12:43Z","url":"/compendium/alopecia"},{"navParent":{"_ref":"7599f50b-36ff-42a5-8d72-82814db9b988","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfbSvV","_type":"subNavigation","_updatedAt":"2024-05-24T05:12:02Z","is_active":true,"_createdAt":"2024-05-24T05:12:02Z","name":"Atopic Dermatitis","_id":"637a0b1e-1b12-42bf-81a3-e6db5a997021","url":"/compendium/atopic-dermatitis"},{"_createdAt":"2024-05-24T05:12:30Z","_rev":"Jz2W7keLhiw1UYkGHfbTJu","name":"Psoriasis","_id":"a9dcce80-4f29-488e-b7ef-51f0fb562a5a","is_active":true,"navParent":{"_ref":"7599f50b-36ff-42a5-8d72-82814db9b988","_type":"reference"},"url":"/compendium/psoriasis","_type":"subNavigation","_updatedAt":"2024-05-24T05:12:36Z"}],"_updatedAt":"2024-05-24T05:10:35Z","url":"/compendium/dermatology","_createdAt":"2024-05-24T05:10:35Z","_id":"7599f50b-36ff-42a5-8d72-82814db9b988","_type":"subNavigation","is_active":true,"_rev":"Jz2W7keLhiw1UYkGHfbSVf"},{"_type":"subNavigation","_updatedAt":"2024-11-25T15:12:43Z","url":"/compendium/gastroenterology","_id":"3c425964-bf72-4f93-bfbc-4d44d42dc2fe","children":[],"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"is_active":true,"_createdAt":"2024-11-25T15:12:24Z","_rev":"I64rexdokWxpEDPZsg5Lox","name":"Gastroenterology"},{"children":[{"name":"ALL/AML","is_active":true,"_createdAt":"2024-05-29T15:28:26Z","_rev":"Iat2IZiT321TmGHwkF66wB","_type":"subNavigation","_id":"d79f2b30-e7f2-4915-bef8-1a73a9190a91","_updatedAt":"2024-05-29T15:28:26Z","url":"/compendium/all","navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"}},{"name":"CLL/SLL","_id":"664a6ece-64dd-41f8-87a0-7f5a47323c3b","_createdAt":"2024-05-29T15:26:57Z","_type":"subNavigation","_rev":"Iat2IZiT321TmGHwkF65Md","_updatedAt":"2024-05-29T15:27:46Z","url":"/compendium/cll","is_active":true,"navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"}},{"navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"},"_createdAt":"2024-05-29T15:28:51Z","_rev":"Iat2IZiT321TmGHwkF67tn","name":"GVHD","_id":"32cf626c-1ce6-4fb5-9dd7-088522dc46e6","_updatedAt":"2024-05-29T15:28:51Z","is_active":true,"_type":"subNavigation","url":"/compendium/gvhd"},{"name":"Hemophilia","_id":"4dd2ce64-8f4d-4285-bc1a-ec40ffc99b51","_updatedAt":"2024-05-24T05:14:15Z","_createdAt":"2024-05-24T05:14:15Z","_rev":"Jz2W7keLhiw1UYkGHfbUDt","_type":"subNavigation","is_active":true,"navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"},"url":"/compendium/hemophilia"},{"_id":"84e2d674-0fe1-4bd1-9d97-2f8bc8589ba0","url":"/compendium/multiple-myeloma","name":"Multiple Myeloma","navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"},"_createdAt":"2024-05-24T05:45:17Z","_rev":"Iat2IZiT321TmGHwkF6NtX","_type":"subNavigation","_updatedAt":"2024-05-29T15:35:07Z","is_active":true},{"navParent":{"_type":"reference","_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4"},"_createdAt":"2024-05-24T05:45:36Z","_rev":"Iat2IZiT321TmGHwkF6a5X","_type":"subNavigation","name":"Myelodysplastic Syndromes","url":"/compendium/myelodysplastic-syndromes","is_active":true,"_updatedAt":"2024-05-29T15:35:22Z","_id":"3a327f90-a5fc-4d87-9a18-02f54cb40b8e"},{"is_active":true,"_createdAt":"2024-05-29T15:29:21Z","_rev":"Up1TL5YPo1fhI8V2tpNnMb","_type":"subNavigation","name":"Myeloproliferative Neoplasms","navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"},"_id":"a6003c4f-e7f0-422a-8129-49a2d78eb113","_updatedAt":"2024-06-05T20:02:27Z","url":"/compendium/mpn"},{"_createdAt":"2024-05-24T05:43:54Z","_rev":"rmdpbbz4U7GL9ExaGp96DY","name":"Non-Hodgkin Lymphoma","_updatedAt":"2024-06-25T17:42:12Z","url":"/compendium/nhl","navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"},"_type":"subNavigation","_id":"fc247a6b-0b33-4e18-ae78-56e677c6bb18","is_active":true},{"_createdAt":"2024-05-24T05:14:40Z","name":"Rare Blood","is_active":true,"navParent":{"_ref":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","_type":"reference"},"_id":"85e2fc3e-ac5c-4b47-8b14-411d730d20d9","_updatedAt":"2024-05-24T05:14:40Z","url":"/compendium/rareblood","_rev":"Jz2W7keLhiw1UYkGHfbUPN","_type":"subNavigation"}],"_updatedAt":"2024-05-24T05:13:48Z","navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_createdAt":"2024-05-24T05:13:48Z","_rev":"Jz2W7keLhiw1UYkGHfbU3q","_type":"subNavigation","_id":"d1c6a8fa-d54d-4aa5-84e5-0e1ee2b639d4","url":"/compendium/hematology","name":"Hematology","is_active":true},{"is_active":true,"_createdAt":"2024-05-24T05:34:29Z","_rev":"N7mKycgLbGtEq6btkLqjkf","name":"Hepatology","_id":"a96e7dbc-b037-41f4-bd5e-d96abf8f3c7d","_updatedAt":"2024-06-11T20:17:54Z","navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"_type":"subNavigation","children":[{"navParent":{"_ref":"a96e7dbc-b037-41f4-bd5e-d96abf8f3c7d","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfbwkP","name":"Liver","_updatedAt":"2024-05-24T05:34:54Z","is_active":true,"_createdAt":"2024-05-24T05:34:54Z","_type":"subNavigation","_id":"2aefee8c-db97-4e7d-b600-efb48e6bcb6c","url":"/compendium/liver-cancer"}]},{"_rev":"Jz2W7keLhiw1UYkGHfbkam","_updatedAt":"2024-05-24T05:23:19Z","is_active":true,"navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"_type":"subNavigation","name":"Immunology","_id":"1b1e3727-8b82-42da-9a62-b20472b9c797","url":"/compendium/immunology","_createdAt":"2024-05-24T05:23:19Z","children":[{"_createdAt":"2024-05-24T05:23:39Z","name":"Autoimmune","_id":"b3daefd0-0ac3-4be2-ad23-f9c3fa37cf37","is_active":true,"navParent":{"_type":"reference","_ref":"1b1e3727-8b82-42da-9a62-b20472b9c797"},"_rev":"Jz2W7keLhiw1UYkGHfbkp8","_type":"subNavigation","_updatedAt":"2024-05-24T05:23:39Z","url":"/compendium/autoimmune"},{"_id":"6016d41d-9d43-49fa-99b6-7caca304f30d","url":"/compendium/Inflammation","navParent":{"_ref":"1b1e3727-8b82-42da-9a62-b20472b9c797","_type":"reference"},"_createdAt":"2024-05-24T05:23:59Z","_rev":"Jz2W7keLhiw1UYkGHfbkzB","name":"Inflammation","is_active":true,"_type":"subNavigation","_updatedAt":"2024-05-24T05:23:59Z"},{"_type":"subNavigation","name":"Lupus","_id":"b537fcea-aea3-40ca-83c1-0907fdc9ccb5","navParent":{"_ref":"1b1e3727-8b82-42da-9a62-b20472b9c797","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfbmd6","_updatedAt":"2024-05-24T05:24:47Z","url":"/compendium/lupus","is_active":true,"_createdAt":"2024-05-24T05:24:47Z"},{"_type":"subNavigation","name":"Myasthenia Gravis","_updatedAt":"2024-05-24T05:25:23Z","navParent":{"_ref":"1b1e3727-8b82-42da-9a62-b20472b9c797","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfbn7F","_id":"ef6c4efc-5932-4148-b626-cbf42e1c49c3","url":"/compendium/myasthenia-gravis","is_active":true,"_createdAt":"2024-05-24T05:25:23Z"}]},{"_rev":"Jz2W7keLhiw1UYkGHfcA9Y","name":"Infectious Disease","_id":"b62af616-818b-4bda-b606-bd64287f9a85","url":"/compendium/infectious-disease","_updatedAt":"2024-05-24T05:35:38Z","children":[{"navParent":{"_ref":"b62af616-818b-4bda-b606-bd64287f9a85","_type":"reference"},"name":"COVID-19","_id":"ffcd30d0-169f-4a8f-9f01-616142f33712","url":"/compendium/covid-19","is_active":true,"_createdAt":"2024-05-24T05:36:03Z","_rev":"rcwwj6TiN2Q0ymhqDyeyP3","_type":"subNavigation","_updatedAt":"2024-05-24T05:36:03Z"},{"_rev":"Jz2W7keLhiw1UYkGHfcAxn","name":"HIV","_id":"a53004c6-9fe2-4b9c-a86a-ad74f9204b3a","url":"/compendium/hiv","is_active":true,"navParent":{"_ref":"b62af616-818b-4bda-b606-bd64287f9a85","_type":"reference"},"_createdAt":"2024-05-24T05:36:22Z","_type":"subNavigation","_updatedAt":"2024-05-24T05:36:29Z"},{"_rev":"rcwwj6TiN2Q0ymhqDyezNO","_id":"ca70e9ab-a981-4629-a766-81f7890b3977","_updatedAt":"2024-05-24T05:37:06Z","name":"RSV","url":"/compendium/rsv","is_active":true,"navParent":{"_ref":"b62af616-818b-4bda-b606-bd64287f9a85","_type":"reference"},"_createdAt":"2024-05-24T05:37:06Z","_type":"subNavigation"},{"_rev":"Jz2W7keLhiw1UYkGHfcFFM","_type":"subNavigation","_updatedAt":"2024-05-24T05:37:53Z","_id":"a0ec0591-b4a1-4723-b984-b681c957523f","url":"/compendium/vaccines","is_active":true,"navParent":{"_ref":"b62af616-818b-4bda-b606-bd64287f9a85","_type":"reference"},"_createdAt":"2024-05-24T05:37:53Z","name":"Vaccines"}],"_type":"subNavigation","is_active":true,"navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"_createdAt":"2024-05-24T05:35:38Z"},{"name":"Mental Health","children":[{"_rev":"rcwwj6TiN2Q0ymhqDyf7Qk","_type":"subNavigation","name":"Major Depressive Disorder","_id":"efcab5a8-97d8-4f5a-ba99-0a0555531f5a","is_active":true,"navParent":{"_type":"reference","_ref":"db67ff69-2c58-4931-ad3d-767a636e38b0"},"_createdAt":"2024-05-24T05:38:58Z","_updatedAt":"2024-05-24T05:38:58Z","url":"/compendium/mdd"},{"is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDyf96m","_id":"f52dbfa9-aefe-4d21-b432-7052a136ae98","_updatedAt":"2024-05-24T05:39:18Z","navParent":{"_type":"reference","_ref":"db67ff69-2c58-4931-ad3d-767a636e38b0"},"_createdAt":"2024-05-24T05:39:18Z","_type":"subNavigation","name":"Sleep","url":"/compendium/sleep"}],"navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"_type":"subNavigation","_id":"db67ff69-2c58-4931-ad3d-767a636e38b0","_updatedAt":"2024-05-24T05:38:33Z","url":"/compendium/mental-health","_createdAt":"2024-05-24T05:38:33Z","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDyf4PU"},{"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"name":"Neurology","_id":"bafe1c52-a8b5-4786-bcee-668409d14a11","_updatedAt":"2024-06-11T20:18:36Z","is_active":true,"_type":"subNavigation","_createdAt":"2024-05-24T05:39:38Z","_rev":"G7uWgc8ggxb5zBvm8zNRmt","children":[{"_updatedAt":"2024-05-24T05:40:18Z","url":"/compendium/dmd","is_active":true,"navParent":{"_ref":"bafe1c52-a8b5-4786-bcee-668409d14a11","_type":"reference"},"_type":"subNavigation","name":"Duchenne Muscular Dystrophy","_createdAt":"2024-05-24T05:40:18Z","_rev":"rcwwj6TiN2Q0ymhqDyfERb","_id":"3e24f5af-027e-4f0b-a7e2-a3ffaf756a35"},{"name":"Epilepsy","_id":"d4e270df-2a59-4109-a7be-9c10f80722a7","_updatedAt":"2024-05-24T05:40:38Z","url":"/compendium/epilepsy","navParent":{"_ref":"bafe1c52-a8b5-4786-bcee-668409d14a11","_type":"reference"},"_createdAt":"2024-05-24T05:40:30Z","_rev":"rcwwj6TiN2Q0ymhqDyfIhq","_type":"subNavigation","is_active":true},{"_updatedAt":"2024-05-24T05:41:07Z","url":"/compendium/multiple-sclerosis","is_active":true,"_createdAt":"2024-05-24T05:41:07Z","_rev":"rcwwj6TiN2Q0ymhqDyfJRc","_id":"7539f9b5-8f2a-4e1b-a10f-8cc748cd1489","navParent":{"_ref":"bafe1c52-a8b5-4786-bcee-668409d14a11","_type":"reference"},"_type":"subNavigation","name":"Multiple Sclerosis"},{"is_active":true,"navParent":{"_ref":"bafe1c52-a8b5-4786-bcee-668409d14a11","_type":"reference"},"_type":"subNavigation","_id":"90ebd8e7-e6d1-4128-8010-0b205fedb430","_updatedAt":"2024-05-24T05:41:29Z","_createdAt":"2024-05-24T05:41:29Z","_rev":"rcwwj6TiN2Q0ymhqDyfJiG","name":"Parkinson Disease","url":"/compendium/parkinson"}]},{"_updatedAt":"2024-09-04T14:25:34Z","is_active":true,"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_rev":"B2kOGngERQtEUh1WG5WXvd","_type":"subNavigation","name":"Obesity","children":[],"_id":"fe48de19-78d2-4ed0-83fa-8884fb340de2","url":"/compendium/obesity","_createdAt":"2024-09-04T14:25:34Z"},{"url":"/compendium/oncology","_type":"subNavigation","_createdAt":"2024-05-24T05:41:55Z","navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"name":"Oncology","_id":"90b398eb-3349-4b6a-b205-780a34cb4717","_updatedAt":"2024-05-24T05:41:55Z","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDyfKov","children":[{"_rev":"rcwwj6TiN2Q0ymhqDyfMpl","_type":"subNavigation","name":"Breast Cancer","_id":"03ea9371-55cd-42e2-b300-7078b94ff467","url":"/compendium/breast-cancer","is_active":true,"_createdAt":"2024-05-24T05:42:17Z","navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_updatedAt":"2024-05-24T05:42:17Z"},{"_createdAt":"2024-05-24T05:42:35Z","name":"Cholangiocarcinoma","_id":"8b57fc91-4191-420c-a224-cb869f8fa0d7","is_active":true,"navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_updatedAt":"2024-05-24T05:42:35Z","url":"/compendium/cholangiocarcinoma","_rev":"rcwwj6TiN2Q0ymhqDyfatY","_type":"subNavigation"},{"_rev":"Jz2W7keLhiw1UYkGHfcTh6","url":"/compendium/colorectal-cancer","is_active":true,"_createdAt":"2024-05-24T05:43:23Z","_type":"subNavigation","name":"Colorectal Cancer","_id":"e45ff858-e1bc-4b4a-9398-e12877b61607","_updatedAt":"2024-05-24T05:43:23Z","navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"}},{"name":"Immuno-Oncology","_id":"289f747b-dffd-4006-a27d-4933a46fd7c1","_updatedAt":"2024-05-24T13:25:09Z","url":"/compendium/immuno-oncology","is_active":true,"navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_createdAt":"2024-05-24T05:44:17Z","_rev":"Jz2W7keLhiw1UYkGHfsKT5","_type":"subNavigation"},{"is_active":true,"navParent":{"_type":"reference","_ref":"90b398eb-3349-4b6a-b205-780a34cb4717"},"_createdAt":"2024-05-29T15:32:02Z","_type":"subNavigation","_id":"9d17bccc-3f33-4793-90e3-0adecfa71fa1","_updatedAt":"2024-05-29T15:32:02Z","_rev":"Iat2IZiT321TmGHwkF6F4B","name":"Liver Cancer","url":"/compendium/liver-cancer"},{"name":"Lung Cancer","_id":"89f99f56-72a9-4dcd-9d8c-3d717d66a5f0","_updatedAt":"2024-05-24T05:44:58Z","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDyfff0","_type":"subNavigation","navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_createdAt":"2024-05-24T05:44:58Z","url":"/compendium/lung-cancer"},{"name":"Non–Small Cell Lung Cancer","_updatedAt":"2024-05-24T13:24:22Z","_id":"85d30c37-d6a1-4028-9c0f-ecdf36de220d","url":"/compendium/nsclc","is_active":true,"navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_createdAt":"2024-05-24T05:45:56Z","_rev":"Jz2W7keLhiw1UYkGHfsIwL","_type":"subNavigation"},{"is_active":true,"name":"Ovarian Cancer","_id":"5a67adcb-11d8-48a6-8c39-b2956f5f3e86","url":"/compendium/ovarian-cancer","navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_createdAt":"2024-05-24T05:46:17Z","_rev":"Jz2W7keLhiw1UYkGHfcbF4","_type":"subNavigation","_updatedAt":"2024-05-24T05:46:17Z"},{"_createdAt":"2024-05-24T05:47:42Z","_rev":"rcwwj6TiN2Q0ymhqDyfmoB","_id":"bcfe0d88-7498-4268-95e6-875c94a2dab5","url":"/compendium/prostate-cancer","is_active":true,"navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_type":"subNavigation","name":"Prostate Cancer","_updatedAt":"2024-05-24T05:47:42Z"},{"navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"_rev":"rcwwj6TiN2Q0ymhqDyfpKE","_id":"a3a04e72-c707-450d-b9d3-f9ebacc9f997","url":"/compendium/skincancer","is_active":true,"_createdAt":"2024-05-24T05:48:18Z","_type":"subNavigation","name":"Skin Cancer","_updatedAt":"2024-05-24T05:48:18Z"},{"navParent":{"_ref":"90b398eb-3349-4b6a-b205-780a34cb4717","_type":"reference"},"name":"Soft Tissue Sarcoma","_id":"6d1dc4b4-1be8-41ee-9bba-90ad4ce546b3","url":"/compendium/soft-tissue-sarcoma","_updatedAt":"2024-05-29T15:30:06Z","is_active":true,"_createdAt":"2024-05-29T15:30:06Z","_rev":"Iat2IZiT321TmGHwkF69Qd","_type":"subNavigation"}]},{"is_active":true,"url":"/compendium/ophthalmology","_type":"subNavigation","_updatedAt":"2024-05-24T05:48:54Z","children":[],"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_id":"eee19078-eb50-46e7-a97c-8f16d79eea97","_createdAt":"2024-05-24T05:48:54Z","_rev":"Jz2W7keLhiw1UYkGHfcePj","name":"Ophthalmology"},{"_id":"e6c5e55f-7a5a-4f23-add2-fbf91df76400","is_active":true,"children":[{"_updatedAt":"2024-05-24T05:49:28Z","url":"/compendium/copd","is_active":true,"navParent":{"_ref":"e6c5e55f-7a5a-4f23-add2-fbf91df76400","_type":"reference"},"_type":"subNavigation","_id":"3a19d535-d61e-43b1-bf6a-d6ced486a0b9","_createdAt":"2024-05-24T05:49:28Z","_rev":"rcwwj6TiN2Q0ymhqDyfrwW","name":"COPD"},{"is_active":true,"navParent":{"_ref":"e6c5e55f-7a5a-4f23-add2-fbf91df76400","_type":"reference"},"_rev":"rcwwj6TiN2Q0ymhqDyfuBv","_type":"subNavigation","url":"/compendium/pah","_createdAt":"2024-05-24T05:49:52Z","name":"Pulmonary Arterial Hypertension","_id":"474080cd-4295-4a70-907d-e1fc93c435cc","_updatedAt":"2024-05-24T05:49:52Z"}],"_type":"subNavigation","_rev":"5DUHcaiKRKj5c8wHOPlDws","name":"Pulmonology","_updatedAt":"2024-06-03T20:54:07Z","navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_createdAt":"2024-05-24T05:49:11Z"},{"_updatedAt":"2024-05-24T05:50:50Z","url":"/compendium/raredisease","children":[{"_id":"9e780f76-2008-441b-ab5f-00d3a6d1a5b0","_updatedAt":"2024-05-24T05:51:19Z","url":"/compendium/sma","is_active":true,"_createdAt":"2024-05-24T05:51:19Z","_rev":"rcwwj6TiN2Q0ymhqDyg1k4","_type":"subNavigation","name":"Spinal Muscular Atrophy","navParent":{"_ref":"de690920-3cdc-4c43-a27e-ba4e38a62059","_type":"reference"}}],"navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_createdAt":"2024-05-24T05:50:50Z","_type":"subNavigation","name":"Rare Disease","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDyg1Ah","_id":"de690920-3cdc-4c43-a27e-ba4e38a62059"},{"name":"Respiratory","_updatedAt":"2024-05-24T05:50:22Z","_type":"subNavigation","_id":"f2a34114-0396-44cb-b241-11ef7b175500","_rev":"Jz2W7keLhiw1UYkGHfcjSf","children":[{"_rev":"rcwwj6TiN2Q0ymhqDyg2wy","_id":"b2b2802f-2918-4431-8f4f-3bc7e6e6042f","_updatedAt":"2024-05-24T05:52:02Z","is_active":true,"navParent":{"_ref":"f2a34114-0396-44cb-b241-11ef7b175500","_type":"reference"},"_createdAt":"2024-05-24T05:52:02Z","_type":"subNavigation","name":"Asthma","url":"/compendium/asthma"},{"_createdAt":"2024-06-03T18:31:07Z","_id":"4dac47d5-8dd1-4e90-b4be-b6b5e605f6f5","navParent":{"_ref":"f2a34114-0396-44cb-b241-11ef7b175500","_type":"reference"},"_rev":"5DUHcaiKRKj5c8wHOPKtuf","_type":"subNavigation","name":"Idiopathic Pulmonary Fibrosis","_updatedAt":"2024-06-03T18:31:07Z","url":"/compendium/ipf","is_active":true}],"is_active":true,"navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"url":"/compendium/respiratory","_createdAt":"2024-05-24T05:50:22Z"},{"url":"/compendium/rheumatology","navParent":{"_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e","_type":"reference"},"_createdAt":"2024-05-24T05:52:28Z","_type":"subNavigation","_rev":"Jz2W7keLhiw1UYkGHfcm6J","_id":"3ecb2952-6710-46b1-ab05-36997bfb4a33","is_active":true,"children":[],"name":"Rheumatology","_updatedAt":"2024-05-24T05:52:28Z"},{"_updatedAt":"2024-05-24T05:52:51Z","url":"/compendium/womens-health","navParent":{"_type":"reference","_ref":"97a2a8fe-1a67-45d7-b1f8-294ab1f64c1e"},"name":"Women's Health","_createdAt":"2024-05-24T05:52:51Z","_rev":"Jz2W7keLhiw1UYkGHfcmDU","_id":"ead467ba-7c17-4a1b-9deb-a7af56a7366e","is_active":true,"_type":"subNavigation","children":[]}],"_createdAt":"2020-04-14T14:04:25Z","_type":"subNavigation","name":"Specialty Area","navParent":null,"sortOrder":1,"is_active":true,"url":"/compendium"},{"_rev":"rcwwj6TiN2Q0ymhqDyHDJ3","_type":"subNavigation","_id":"db56b0e2-ad58-4407-aff2-5c27cb3145c1","_updatedAt":"2024-05-23T21:04:52Z","_createdAt":"2024-05-23T20:47:34Z","name":"Spotlight","is_active":true,"navParent":null,"subQuery":[{"_createdAt":"2024-05-23T21:04:56Z","_type":"subNavigation","_updatedAt":"2024-05-23T21:05:49Z","navParent":{"_ref":"db56b0e2-ad58-4407-aff2-5c27cb3145c1","_type":"reference"},"name":"Free In-Person Regional Events Focused on Oncology and Population Health","url":"/ivbmevents?display=home","is_active":true,"_id":"f5b2c97b-d6d4-468b-8a9a-4814364994c8","children":[],"_rev":"uJbbwQWkLESsncBrcJSd1N"}],"sortOrder":2},{"url":"/topic","is_active":true,"_createdAt":"2020-04-14T14:05:54Z","name":"Topics","_id":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_updatedAt":"2020-08-21T22:11:57Z","_rev":"iEeBpgQLYwZXMeCflboLMu","navParent":null,"subQuery":[{"navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfbHQ4","_type":"subNavigation","_createdAt":"2024-05-24T05:05:19Z","sortOrder":1,"name":"Biosimilars","_id":"43207521-4e5f-42d2-b013-34763a4d964c","url":"/compendium/biosimilars","is_active":true,"_updatedAt":"2024-05-24T05:05:19Z","children":[]},{"_updatedAt":"2024-06-12T13:58:35Z","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_rev":"N7mKycgLbGtEq6btkPIW3d","url":"/topic/center-on-health-equity-and-access","children":[],"_createdAt":"2022-12-23T21:04:41Z","_type":"subNavigation","is_active":true,"name":"Center on Health Equity \u0026 Access","_id":"4161ff97-2901-4526-80ee-3749b6dc6345"},{"url":"/compendium/digital-health","_id":"232e30a0-2f7d-4ce1-9e4d-cc0cee73b20a","_createdAt":"2024-05-24T05:56:42Z","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_rev":"rcwwj6TiN2Q0ymhqDygl51","_type":"subNavigation","name":"Digital Health","_updatedAt":"2024-05-24T05:56:42Z","is_active":true,"children":[]},{"_id":"3887cee2-5461-4cb3-b54f-297fcceb11ee","_type":"subNavigation","_updatedAt":"2024-05-24T05:57:01Z","url":"/formulary","navParent":{"_type":"reference","_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2"},"children":[],"_rev":"Jz2W7keLhiw1UYkGHfdAmX","is_active":true,"_createdAt":"2024-05-24T05:57:01Z","name":"Formulary"},{"_updatedAt":"2024-05-24T05:57:41Z","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDygmDl","_createdAt":"2024-05-24T05:57:41Z","_type":"subNavigation","_id":"56aff93b-4f24-48fc-9dda-2d394397f956","url":"/compendium/gene-therapy","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"name":"Gene Therapy","children":[]},{"_type":"subNavigation","url":"/guidelines","children":[],"is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDygv9D","_id":"69723346-76b2-4896-b2d9-2db53ed5da96","_updatedAt":"2024-05-24T06:00:55Z","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"name":"Guidelines","_createdAt":"2024-05-24T06:00:55Z"},{"is_active":true,"navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_createdAt":"2024-05-24T13:53:24Z","_type":"subNavigation","_id":"cd6edcff-faa3-4bee-9071-042f8186052d","name":"Health Care Administration","_updatedAt":"2024-05-24T14:10:39Z","children":[{"navParent":{"_ref":"cd6edcff-faa3-4bee-9071-042f8186052d","_type":"reference"},"_createdAt":"2024-05-24T05:58:26Z","_type":"subNavigation","name":"Employers","_id":"83fca4ec-4ff0-4766-9e49-0376d44179e8","_updatedAt":"2024-05-24T13:53:42Z","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDz6EMB","url":"/compendium/employers"},{"_updatedAt":"2024-05-24T13:53:53Z","is_active":true,"navParent":{"_ref":"cd6edcff-faa3-4bee-9071-042f8186052d","_type":"reference"},"_type":"subNavigation","_id":"5647b438-aca9-4b57-9d4d-2df660b5a6ce","_createdAt":"2024-05-24T05:58:44Z","_rev":"rcwwj6TiN2Q0ymhqDz6F3s","name":"Medicare","url":"/compendium/medicare"},{"url":"/compendium/reimbursement","is_active":true,"_type":"subNavigation","_id":"2c8ff713-9c43-4afc-aaca-e33ceb98f00c","name":"Reimbursement","_updatedAt":"2024-05-24T13:54:23Z","navParent":{"_ref":"cd6edcff-faa3-4bee-9071-042f8186052d","_type":"reference"},"_createdAt":"2024-05-24T05:59:16Z","_rev":"rcwwj6TiN2Q0ymhqDz6G8S"}],"_rev":"rcwwj6TiN2Q0ymhqDz7eaC","url":"/"},{"_createdAt":"2020-04-14T14:06:29Z","_type":"subNavigation","url":"/topic/healthcare-cost","children":[],"_updatedAt":"2021-02-25T17:30:59Z","is_active":true,"navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_rev":"wx7I38TXtYeZdHCfn60Syn","name":"Health Care Cost","_id":"c9a8f6fd-0ad0-4a82-a385-13c03fe688d0"},{"name":"Health Care Delivery","url":"/topic/healthcare-delivery","_updatedAt":"2021-02-25T17:29:58Z","is_active":true,"navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_createdAt":"2020-04-14T14:06:43Z","_rev":"YN5IiYQkhJ3hq0R7jM8DQW","_type":"subNavigation","_id":"d01b9875-6e51-42d1-bdf5-93fd8771855c","children":[]},{"url":"/topic/insurance","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_type":"subNavigation","_id":"d8eab058-f5ec-4c42-a95a-941c0a506543","is_active":true,"children":[],"name":"Insurance","_rev":"lslStCipHxtG437RQOGJ7p","_createdAt":"2020-04-14T14:07:01Z","_updatedAt":"2022-12-21T19:05:52Z"},{"_updatedAt":"2020-04-14T14:07:15Z","_rev":"T035zdq5xruIFPyK3OzgdQ","_type":"subNavigation","_id":"fd066f36-78ee-4112-a121-4e02f8e45b0b","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"name":"Policy","url":"/topic/policy","children":[],"is_active":true,"_createdAt":"2020-04-14T14:07:15Z"},{"name":"Population Health","children":[],"navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_updatedAt":"2024-05-24T06:01:29Z","is_active":true,"_rev":"rcwwj6TiN2Q0ymhqDygvgV","_type":"subNavigation","_createdAt":"2024-05-24T05:59:24Z","_id":"d7893fef-5eb0-4b2d-b13d-a0bec73b2c14","url":"/compendium/population"},{"children":[],"navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_rev":"Jz2W7keLhiw1UYkGHfsKLu","_updatedAt":"2024-05-24T13:24:58Z","_type":"subNavigation","name":"Product Approvals and Launches","_createdAt":"2024-05-24T06:01:51Z","url":"/approvals-launches","is_active":true,"_id":"6188ac2f-7ec8-4cbb-a154-5822f606f3fa"},{"name":"Technology","is_active":true,"children":[],"_createdAt":"2020-04-14T14:07:28Z","_rev":"QxOJBWa4XErmibN6Cb5bN0","_type":"subNavigation","_updatedAt":"2020-04-14T14:07:28Z","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_id":"4e2fe99b-3ac4-4b48-89ed-774dd51675df","url":"/topic/technology"},{"url":"/topic/value-based-care","is_active":true,"_createdAt":"2020-04-14T14:07:42Z","name":"Value-Based Care","_id":"22bd1bd6-88a6-4278-a846-e086cf30b141","navParent":{"_ref":"8f999f83-7d66-4c5d-a82c-ecf6b72037f2","_type":"reference"},"_rev":"T035zdq5xruIFPyK3OzhkC","_updatedAt":"2020-04-14T14:07:42Z","_type":"subNavigation","children":[]}],"_type":"subNavigation","sortOrder":2},{"is_active":true,"url":"/ivbm","name":"Institute for Value-Based Medicine","_createdAt":"2020-04-27T18:48:09Z","_type":"subNavigation","_rev":"N0LuVAjtHhQSyVgQyS0Kyv","_id":"6389c35d-3d2d-41db-978d-b3aa4d10cb8e","_updatedAt":"2020-04-27T18:48:23Z","sortOrder":3,"navParent":null,"subQuery":[{"navParent":{"_type":"reference","_ref":"6389c35d-3d2d-41db-978d-b3aa4d10cb8e"},"name":"All Coverage","_updatedAt":"2020-05-06T13:11:16Z","_createdAt":"2020-05-06T13:11:16Z","_rev":"cyKVTGb2fpu5E4X0UMrv4p","_type":"subNavigation","_id":"f7379c68-40be-45e4-9747-484dcec584d3","is_active":true,"children":[],"url":"/ivbm"},{"_updatedAt":"2020-04-27T18:49:41Z","url":"/ivbm/event-coverage","_createdAt":"2020-04-27T18:49:41Z","_rev":"k2D4PisPM2pBS5NIl95QbN","children":[],"is_active":true,"name":"Event Coverage","_type":"subNavigation","navParent":{"_ref":"6389c35d-3d2d-41db-978d-b3aa4d10cb8e","_type":"reference"},"_id":"cc8a827f-3e94-413a-aa0c-0d8b40eb5f18"},{"_type":"subNavigation","_updatedAt":"2020-04-27T18:50:03Z","name":"Interviews","url":"/ivbm/interviews","is_active":true,"navParent":{"_ref":"6389c35d-3d2d-41db-978d-b3aa4d10cb8e","_type":"reference"},"_createdAt":"2020-04-27T18:50:03Z","_rev":"k2D4PisPM2pBS5NIl95RlO","_id":"aa3f3bb8-9e8c-457d-aeb6-7b94b968395a","children":[]},{"_rev":"XtnP0djhkej33kSTbdUgmN","_type":"subNavigation","name":"News","_createdAt":"2020-04-27T18:50:34Z","navParent":{"_ref":"6389c35d-3d2d-41db-978d-b3aa4d10cb8e","_type":"reference"},"_id":"1be7e99c-8d37-4d70-a009-67eb03fae5ba","url":"/ivbm/news","is_active":true,"_updatedAt":"2020-04-27T18:50:34Z","children":[]}]},{"_id":"9a07b754-3383-43ac-9d2d-a370d44406d1","navParent":null,"_createdAt":"2020-04-14T14:09:11Z","_type":"subNavigation","sortOrder":4,"_rev":"lsW1cEPdRFwwIdupAS8Stb","name":"About AJMC","subQuery":[{"is_active":true,"_createdAt":"2020-05-07T17:05:52Z","_type":"subNavigation","navParent":{"_ref":"9a07b754-3383-43ac-9d2d-a370d44406d1","_type":"reference"},"_rev":"NGYpFwzJghlKjBIAt48VzS","_updatedAt":"2020-05-07T17:05:52Z","name":"AJMC Journals","_id":"4e10ead3-6a42-43df-b251-b93b912a24cb","url":"/about","children":[]},{"_updatedAt":"2020-04-14T14:09:38Z","navParent":{"_ref":"9a07b754-3383-43ac-9d2d-a370d44406d1","_type":"reference"},"url":"/anniversary","is_active":true,"name":"Anniversary","children":[],"_type":"subNavigation","_id":"4451f4fa-a919-45b4-b6e5-282668cd792e","_createdAt":"2020-04-14T14:09:38Z","_rev":"rHX8vIEJKWyjgUO02y82fe"},{"_createdAt":"2020-04-14T14:10:37Z","navParent":{"_ref":"9a07b754-3383-43ac-9d2d-a370d44406d1","_type":"reference"},"name":"Author Forms","is_active":true,"children":[],"url":"/authorshipforms","_rev":"VmKMEDy0rHs5jzhO3eZVVM","_type":"subNavigation","_id":"99bccc8e-9329-496f-b588-ec3d080f0859","_updatedAt":"2020-06-09T11:44:06Z"},{"_id":"518317a5-297f-4c4f-9d2a-6da7b8c98d9c","_updatedAt":"2020-05-06T12:53:11Z","_createdAt":"2020-04-14T14:10:19Z","is_active":true,"_rev":"0JTsteyxJPdyCvciQ9yBPv","_type":"subNavigation","url":"/authors","children":[],"navParent":{"_ref":"9a07b754-3383-43ac-9d2d-a370d44406d1","_type":"reference"},"name":"Authors"},{"url":"/seema-sonnad-nomination","is_active":true,"_rev":"m6BzyPIGe9IGx2bV3pSCbq","children":[],"_type":"subNavigation","_updatedAt":"2020-06-15T17:13:51Z","_createdAt":"2020-06-15T17:13:51Z","_id":"a96a44c9-4d51-47c6-8f81-4263bd2f58b4","navParent":{"_ref":"9a07b754-3383-43ac-9d2d-a370d44406d1","_type":"reference"},"name":"Nominate a Rising Leader"},{"_updatedAt":"2023-03-14T13:29:28Z","is_active":true,"children":[],"_createdAt":"2023-03-14T13:29:28Z","name":"Submit a Manuscript","_rev":"TctAtfg0qER1kILh39bPC4","_id":"4420e458-acb4-4edb-9f33-c4fc4504ff41","url":"/submit-a-manuscript","navParent":{"_ref":"9a07b754-3383-43ac-9d2d-a370d44406d1","_type":"reference"},"_type":"subNavigation"}],"_updatedAt":"2020-04-27T18:48:27Z","is_active":true}],"site_setting":{"enableSanity2":true,"name":"AJMC - Managed Care News, Research, and Expert Insights","creativeLayout":null,"siteURL":"www.ajmc.com","keywords":["American Journal of Managed Care","AJMC"],"creativeLayoutLatestNews":null,"gaID":"UA-155582410-5,UA-11140057-3","_type":"siteSettings","socialLinks":[{"_key":"5a09ae68c48c","title":"Facebook","url":"https://www.facebook.com/TheAmericanJournalOfManagedCare","blank":true,"_type":"urlArray"},{"url":"https://twitter.com/AJMC_Journal","blank":true,"_type":"urlArray","_key":"ad6b3d250e0b","title":"Twitter"},{"_type":"urlArray","_key":"7d1e53fa7d09","title":"LinkedIn","url":"https://www.linkedin.com/company/american-journal-of-managed-care/","blank":true},{"url":"https://www.instagram.com/ajmcjournal/","blank":true,"_type":"urlArray","_key":"2478204aa05c","title":"Instagram"},{"blank":true,"_type":"urlArray","_key":"0ba4cf990c2f","title":"RSS","url":"/rss"}],"description":"The American Journal of Managed Care provides insights into the latest news and research in managed care across multimedia platforms.","_id":"siteSettings","footerLinks":[{"_type":"urlArray","_key":"6170fdefc8129a5a7ef9dfdd78a2573e","title":"About","url":"/about-us"},{"_type":"urlArray","_key":"281c240875d5","title":"Contact","url":"/contactus"},{"title":"Editorial Boards","url":"/editorial-boards","_type":"urlArray","_key":"25e9e6fb7b4422cd0ac20e1a1d993228"},{"_key":"20a44c137e8d","title":"Advertise","url":"/advertise","_type":"urlArray"},{"title":"Do Not Sell My Information","url":"https://www.mjhlifesciences.com/ccpa?domain=www.ajmc.com","blank":true,"_type":"urlArray","_key":"21b84fcc9b6e"},{"_type":"urlArray","_key":"2f35307aab1f","title":"Terms \u0026 Conditions","url":"/terms"},{"_type":"urlArray","_key":"50ecd8627d01","title":"Privacy Policy","url":"/privacy"}],"_createdAt":"2020-04-14T14:14:32Z","salesforceDMPId":"tr3xsudox","_updatedAt":"2024-06-04T19:08:40Z","_rev":"4ivhMQjTvj4eF8IoNFokPn","copyRightText":"AJMC®"},"clinicalData":[{"_id":"4ee49086-e720-4a65-883e-4efc24de53bb","name":"Center on Health Equity \u0026 Access","identifier":"center-on-health-equity-and-access","sortOrder":null,"children":[]},{"identifier":"clinical","sortOrder":null,"children":[],"_id":"topic_clinical","name":"Clinical"},{"_id":"topic_healthcare-cost","name":"Health Care Cost","identifier":"healthcare-cost","sortOrder":null,"children":[]},{"_id":"topic_healthcare-delivery","name":"Health Care Delivery","identifier":"healthcare-delivery","sortOrder":null,"children":[]},{"_id":"topic_insurance","name":"Insurance","identifier":"insurance","sortOrder":null,"children":[]},{"children":[],"_id":"topic_policy","name":"Policy","identifier":"policy","sortOrder":null},{"_id":"topic_technology","name":"Technology","identifier":"technology","sortOrder":null,"children":[]},{"identifier":"value-based-care","sortOrder":null,"children":[],"_id":"topic_value-based-care","name":"Value-Based Care"}],"seo_data":[],"recent_news":[{"_id":"c1bb1c8c-298c-4573-a961-9068b91850ac","thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","summary":"A study in Japan found that antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics.","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"published":"2024-11-27T17:30:00.000Z","authorMapping":{"_id":"00af9d05-a2c4-4451-a6d1-0e28b08cbb65","biography":[{"style":"normal","_key":"936ecf4b7f0c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Brooke is an assistant editor for ","_key":"8d68730a8da0"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"730c46c984c9"},{"_type":"span","marks":[],"text":"® (","_key":"0b218fbaa571"},{"marks":["em"],"text":"AJMC","_key":"b1b5b3d9cff0","_type":"span"},{"_type":"span","marks":[],"text":"®). She joined ","_key":"7de919198f04"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"f31a60d737e2"},{"_key":"df11193684f8","_type":"span","marks":[],"text":" in 2023, where she produces written content covering multiple disease states."}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"5731fbb8e0ae","_type":"span"}],"_type":"block","style":"normal","_key":"9af540ce04de"},{"children":[{"text":"She has a BA in journalism from Seton Hall University. You can connect with Brooke on ","_key":"bb68b5e8ee83","_type":"span","marks":[]},{"text":"LinkedIn","_key":"4bb222fe2840","_type":"span","marks":["80a1c1a9d7cd"]},{"marks":[],"text":".","_key":"c87621477700","_type":"span"}],"_type":"block","style":"normal","_key":"98aee68dab9d","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/brooke-mccormick-1a254b1b6/","_key":"80a1c1a9d7cd"}]}],"_updatedAt":"2024-05-20T19:29:20Z","url":{"current":"brooke-mccormick","_type":"slug"},"_rev":"m9zO7fOEUWAduYt5irO78Q","lastName":"McCormick","displayName":"Brooke McCormick","_createdAt":"2023-06-21T17:59:19Z","_type":"author","profileImage":{"asset":{"_ref":"image-1fe4e81696463cdd9c1d6b62a2e47c2228d7df99-430x430-png","_type":"reference"},"_type":"mainImage","alt":"Brooke McCormick"},"firstName":"Brooke"},"factCheckAuthorMapping":null},{"published":"2024-11-27T17:11:13.855Z","authorMapping":{"lastName":"Munz","_createdAt":"2023-07-19T18:48:50Z","url":{"current":"kyle-munz","_type":"slug"},"firstName":"Kyle","_rev":"m9zO7fOEUWAduYt5irO25q","_type":"author","_id":"30e9dc45-7c46-468b-b88c-40fcb46b4537","profileImage":{"_type":"mainImage","alt":"Kyle Munz","asset":{"_ref":"image-afb5da0a933e7f6f632d76cd52a5bc1c1243fb36-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:25:58Z","displayName":"Kyle Munz"},"factCheckAuthorMapping":null,"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","summary":"The authors emphasize the value of subgroup analyses for tracking patterns in spinal muscular atrophy (SMA), as opposed to drawing mean conclusions across entire cohorts. ","thumbnail":{"_type":"mainImage","alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"}},"url":{"current":"decoding-sma-progression-hfmse-analysis-spotlights-variability","_type":"slug"},"_id":"c912acfb-e0e8-4e31-9ade-a3c12a94ad04","contentCategory":{"_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh"}},{"authorMapping":{"biography":[{"children":[{"_type":"span","marks":[],"text":"Tim Smith joined the MJH Life Sciences team as an assistant editor for HCPLive in August 2022. He graduated from UC Berkeley with a degree in political science, working in multimedia journalism as a staff writer prior to joining MJH. In his spare time, he enjoys reading, watching TV, listening to podcasts, and rock climbing.","_key":"c85a7dbc8fbf0"}],"_type":"block","style":"normal","_key":"c790bc7dbcf8","markDefs":[]}],"_updatedAt":"2023-04-06T16:01:28Z","firstName":"Tim","displayName":"Tim Smith","_rev":"lwnmFG5EE0bzefXlfbjLv5","_type":"author","_id":"3acb1b2f-e1e7-4430-9698-9c178febb970","_createdAt":"2023-04-06T16:01:28Z","middleName":"Smith","url":{"current":"tim-smith","_type":"slug"}},"contentCategory":{"name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory"},"title":"2025 GOLD Report: New Insights on COPD Risks, Management","summary":"The 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report highlighted climate change, cardiovascular risk, and pulmonary hypertension.","url":{"_type":"slug","current":"2025-gold-report-new-insights-on-copd-risks-management"},"published":"2024-11-27T17:00:00.000Z","_id":"e58efc36-22a9-40ef-af7f-e8aed32fc98f","thumbnail":{"_type":"mainImage","alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com","asset":{"_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg","_type":"reference"}},"factCheckAuthorMapping":null},{"factCheckAuthorMapping":null,"summary":"Accompanying these findings is a call for refined treatment strategies that have potential to better outcomes among patients who have unresectable stage III non–small cell lung cancer (NSCLC).","thumbnail":{"_type":"mainImage","alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"}},"url":{"current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies","_type":"slug"},"published":"2024-11-27T16:36:49.639Z","authorMapping":{"_updatedAt":"2024-08-07T15:47:36Z","_rev":"4vyIlJfwMwqB8NbLEufdwW","_type":"author","_id":"author_51b2956e2bd42e0d6e35a66971fd60bc","biography":[{"_key":"643be033259e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Maggie is an editor for The American Journal of Managed Care® (AJMC®) and produces written, video, and podcast content covering several disease states. She joined AJMC® in 2019, and has been with AJMC®’s parent company, MJH Life Sciences®, since 2014, when she started as a copy editor.","_key":"abc0e18a29ce0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"f4070c315fab","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/maggielshaw/","_key":"159c764717fb"}],"children":[{"_type":"span","marks":[],"text":"She has a BA in English from Penn State University. You can connect with Maggie on ","_key":"8e1abe71bcd2"},{"marks":["159c764717fb"],"text":"LinkedIn","_key":"abc0e18a29ce1","_type":"span"},{"_type":"span","marks":[],"text":".","_key":"abc0e18a29ce2"}],"_type":"block"}],"profileImage":{"_type":"mainImage","alt":"Maggie L. Shaw","asset":{"_ref":"image-7219c501186d8cbe6d25614b5b22645ea1c6fe2c-600x619-jpg","_type":"reference"}},"url":{"current":"maggie-l-shaw","_type":"slug"},"displayName":"Maggie L. Shaw","_createdAt":"2020-05-05T10:50:09Z"},"_id":"5fb81c5e-0e79-4887-a17f-df70e2228acf","title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","contentCategory":{"name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory"}}],"latest_publications":[{"issueGroup":{"_ref":"477f9888-ea5b-4621-bb40-41487563b322","_type":"reference"},"published":"2024-11-22T12:37:00.000Z","authorDetails":[{"biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_key":"f56917041c08","_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for "},{"text":"Evidence-Based Oncology, ","_key":"8c710bb1d962","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for ","_key":"1b94f48924f3"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_key":"953d8c643cce","_type":"span","marks":["em"],"text":"AJMC"},{"_key":"182af2348b04","_type":"span","marks":[],"text":" readers. "}],"_type":"block","style":"normal","_key":"80606b0b2412"},{"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"_key":"9737335da1ed2","_type":"span","marks":[],"text":"."}],"_type":"block","style":"normal","_key":"a03d32973d6e","markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4","nofollow":true,"blank":true}]}],"showSocialShare":null,"displayName":"Mary Caffrey","firstName":null,"lastName":null,"url":{"_type":"slug","current":"mary-caffrey"},"profileImage":null}],"url":"to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask","factCheckBy":[{"displayName":"Mary Caffrey","firstName":null,"lastName":null,"url":{"current":"mary-caffrey","_type":"slug"},"profileImage":null,"biography":[{"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for ","_key":"f56917041c08"},{"_key":"8c710bb1d962","_type":"span","marks":["em"],"text":"Evidence-Based Oncology, "},{"_key":"1b94f48924f3","_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"953d8c643cce"},{"_type":"span","marks":[],"text":" readers. ","_key":"182af2348b04"}],"_type":"block","style":"normal","_key":"80606b0b2412","markDefs":[]},{"markDefs":[{"_key":"4f88673cb2c4","nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/"}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"text":".","_key":"9737335da1ed2","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"a03d32973d6e"}],"showSocialShare":null}],"_id":"5877a6f2-9fdc-47af-8a5c-89e09960f92a","title":"To Improve Clinical Trial Equity in Multiple Myeloma, Just Ask","summary":null,"thumbnail":{"_type":"mainImage","asset":{"metadata":{"hasAlpha":false,"lqip":"data:image/jpeg;base64,/9j/2wBDAAYEBQYFBAYGBQYHBwYIChAKCgkJChQODwwQFxQYGBcUFhYaHSUfGhsjHBYWICwgIyYnKSopGR8tMC0oMCUoKSj/2wBDAQcHBwoIChMKChMoGhYaKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCj/wAARCAAFABQDASIAAhEBAxEB/8QAFwABAAMAAAAAAAAAAAAAAAAAAAIFCP/EAB0QAAICAwADAAAAAAAAAAAAAAECAAMEERITITP/xAAVAQEBAAAAAAAAAAAAAAAAAAABAv/EABcRAQEBAQAAAAAAAAAAAAAAAAAxAQL/2gAMAwEAAhEDEQA/ANFmtqktPkY7IEjis1mQlfRHXvYiI7U8xcLjtr7OYiIKf//Z","dimensions":{"aspectRatio":3.8,"height":115,"_type":"sanity.imageDimensions","width":437},"isOpaque":true,"blurHash":"DARW3j9v?vR.IV~qWXM{ayof","_type":"sanity.imageMetadata","palette":{"dominant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":1.36,"background":"#c5cdd0"},"_type":"sanity.imagePalette","darkMuted":{"foreground":"#fff","title":"#fff","population":0.41,"background":"#383838","_type":"sanity.imagePaletteSwatch"},"muted":{"background":"#60829c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.66},"lightVibrant":{"background":"#a4daec","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.02},"darkVibrant":{"population":0.5,"background":"#15445f","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightMuted":{"background":"#c5cdd0","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":1.36},"vibrant":{"foreground":"#fff","title":"#fff","population":0.07,"background":"#678db6","_type":"sanity.imagePaletteSwatch"}}},"sha1hash":"3e665a0c15a17fc3c7ade987a36f77617f865715","_createdAt":"2024-11-22T12:47:16Z","_updatedAt":"2024-11-22T12:47:16Z","uploadId":"S6qsHDgdYFzzPaJkPMiq04qdRlFigqm8","_rev":"qMZkEXqBAV3IRERLM7zYaX","path":"images/0vv8moc6/ajmc/3e665a0c15a17fc3c7ade987a36f77617f865715-437x115.jpg","size":8393,"originalFilename":"CHEA LOGO.jpg","_type":"sanity.imageAsset","mimeType":"image/jpeg","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/3e665a0c15a17fc3c7ade987a36f77617f865715-437x115.jpg","_id":"image-3e665a0c15a17fc3c7ade987a36f77617f865715-437x115-jpg","extension":"jpg","assetId":"3e665a0c15a17fc3c7ade987a36f77617f865715"}}},{"_id":"e122e007-e3bd-49b9-982a-29e287e95906","thumbnail":{"_type":"mainImage","asset":{"_type":"sanity.imageAsset","sha1hash":"54f2a4431fd4ea73ec6c2ec625fd0d107129c22d","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/54f2a4431fd4ea73ec6c2ec625fd0d107129c22d-285x121.png","assetId":"54f2a4431fd4ea73ec6c2ec625fd0d107129c22d","metadata":{"hasAlpha":false,"lqip":"data:image/png;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":285,"aspectRatio":2.355371900826446,"height":121},"isOpaque":true,"blurHash":"MQQ9ycah-:Rkx[~pM|D*%Lt7_2IVt6a{ay","_type":"sanity.imageMetadata","palette":{"vibrant":{"background":"#5a0696","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":3.6},"dominant":{"background":"#510684","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":5.11},"_type":"sanity.imagePalette","darkMuted":{"title":"#fff","population":1.1,"background":"#663881","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.66,"background":"#7a5f8f"},"lightVibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":1.44,"background":"#deb7ee"},"darkVibrant":{"title":"#fff","population":5.11,"background":"#510684","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"background":"#b6aac4","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":0.23}}},"mimeType":"image/png","path":"images/0vv8moc6/ajmc/54f2a4431fd4ea73ec6c2ec625fd0d107129c22d-285x121.png","size":3589,"_updatedAt":"2024-11-21T18:37:58Z","originalFilename":"NYU Lang Health.png","extension":"png","uploadId":"TBdykeEPkoVIc4yGVg1aMDXZqoY4mmnp","_rev":"EbkpNMUbiIwDU1ASliP5Sw","_createdAt":"2024-11-21T18:37:58Z","_id":"image-54f2a4431fd4ea73ec6c2ec625fd0d107129c22d-285x121-png"}},"url":"collaborating-for-cancer-care-equity-community-and-academic-insights","issueGroup":{"_type":"reference","_ref":"477f9888-ea5b-4621-bb40-41487563b322"},"title":"Collaborating for Cancer Care Equity: Community and Academic Insights","summary":"Coverage from the recent Institute for Value-Based Medicine event with NYU Langone Health.","published":"2024-11-21T18:30:00.000Z","authorDetails":[{"profileImage":{"_type":"mainImage","alt":"Maggie L. Shaw","asset":{"_ref":"image-7219c501186d8cbe6d25614b5b22645ea1c6fe2c-600x619-jpg","_type":"reference"}},"biography":[{"children":[{"_type":"span","marks":[],"text":"Maggie is an editor for The American Journal of Managed Care® (AJMC®) and produces written, video, and podcast content covering several disease states. She joined AJMC® in 2019, and has been with AJMC®’s parent company, MJH Life Sciences®, since 2014, when she started as a copy editor.","_key":"abc0e18a29ce0"}],"_type":"block","style":"normal","_key":"643be033259e","markDefs":[]},{"_key":"f4070c315fab","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/maggielshaw/","_key":"159c764717fb"}],"children":[{"_key":"8e1abe71bcd2","_type":"span","marks":[],"text":"She has a BA in English from Penn State University. You can connect with Maggie on "},{"_type":"span","marks":["159c764717fb"],"text":"LinkedIn","_key":"abc0e18a29ce1"},{"_type":"span","marks":[],"text":".","_key":"abc0e18a29ce2"}],"_type":"block","style":"normal"}],"showSocialShare":null,"displayName":"Maggie L. Shaw","firstName":null,"lastName":null,"url":{"current":"maggie-l-shaw","_type":"slug"}}],"factCheckBy":[{"lastName":null,"url":{"_type":"slug","current":"maggie-l-shaw"},"profileImage":{"alt":"Maggie L. Shaw","asset":{"_ref":"image-7219c501186d8cbe6d25614b5b22645ea1c6fe2c-600x619-jpg","_type":"reference"},"_type":"mainImage"},"biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Maggie is an editor for The American Journal of Managed Care® (AJMC®) and produces written, video, and podcast content covering several disease states. She joined AJMC® in 2019, and has been with AJMC®’s parent company, MJH Life Sciences®, since 2014, when she started as a copy editor.","_key":"abc0e18a29ce0"}],"_type":"block","style":"normal","_key":"643be033259e"},{"markDefs":[{"href":"https://www.linkedin.com/in/maggielshaw/","_key":"159c764717fb","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"She has a BA in English from Penn State University. You can connect with Maggie on ","_key":"8e1abe71bcd2"},{"_type":"span","marks":["159c764717fb"],"text":"LinkedIn","_key":"abc0e18a29ce1"},{"text":".","_key":"abc0e18a29ce2","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f4070c315fab"}],"showSocialShare":null,"displayName":"Maggie L. Shaw","firstName":null}]},{"issueGroup":{"_ref":"477f9888-ea5b-4621-bb40-41487563b322","_type":"reference"},"title":"Elevating Value in Cancer Care With Innovations, Accessibility, Equity","summary":"Coverage from the IVBM Regional event in Denver, Colorado.","thumbnail":{"_type":"mainImage","asset":{"extension":"png","_rev":"AGf4LvcO2r7q1La1cjaXrz","mimeType":"image/png","sha1hash":"c93bf646d31467af3bf1146ded1ddb1b32755d08","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/c93bf646d31467af3bf1146ded1ddb1b32755d08-2022x645.png","assetId":"c93bf646d31467af3bf1146ded1ddb1b32755d08","_updatedAt":"2024-07-23T15:37:52Z","uploadId":"gJzaHcTHR9p1SOaC0U8krFjLzNeOH32L","size":266092,"_type":"sanity.imageAsset","path":"images/0vv8moc6/ajmc/c93bf646d31467af3bf1146ded1ddb1b32755d08-2022x645.png","_createdAt":"2024-07-23T15:37:52Z","_id":"image-c93bf646d31467af3bf1146ded1ddb1b32755d08-2022x645-png","metadata":{"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"height":645,"_type":"sanity.imageDimensions","width":2022,"aspectRatio":3.1348837209302327},"isOpaque":false,"blurHash":"D85Zzn4T?^H;oI.ADg%MM_j=","_type":"sanity.imageMetadata","palette":{"dominant":{"population":1.07,"background":"#18a3d3","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"_type":"sanity.imagePalette","darkMuted":{"title":"#fff","population":0.24,"background":"#28374c","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.19,"background":"#61739a"},"lightVibrant":{"title":"#fff","population":0.01,"background":"#5ce4fc","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"darkVibrant":{"background":"#064487","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.04},"lightMuted":{"foreground":"#000","title":"#fff","population":0.04,"background":"#d5bec1","_type":"sanity.imagePaletteSwatch"},"vibrant":{"title":"#fff","population":1.07,"background":"#18a3d3","_type":"sanity.imagePaletteSwatch","foreground":"#fff"}}},"originalFilename":"AJMC_Denver_Final 1.png"}},"url":"elevating-value-in-cancer-care-with-innovations-accessibility-equity","published":"2024-11-21T17:23:00.000Z","authorDetails":[{"url":{"_type":"slug","current":"cameron-santoro"},"profileImage":{"_type":"mainImage","alt":"Cameron Santoro","asset":{"_ref":"image-6ae51a61642a5ecba7cf4085fe97e68814e3c917-430x430-png","_type":"reference"}},"biography":[{"children":[{"_type":"span","marks":[],"text":"Cameron Santoro is an associate editor for ","_key":"93662c5c4cfd"},{"_key":"213c257c1eca","_type":"span","marks":["em"],"text":"The American Journal of Managed Care"},{"_type":"span","marks":["superscript"],"text":"®","_key":"f546acb0aa91"},{"text":" (","_key":"acd931edd707","_type":"span","marks":[]},{"marks":["em"],"text":"AJMC","_key":"843f7d4e787d","_type":"span"},{"_type":"span","marks":["superscript"],"text":"®","_key":"7c809e803edb"},{"_type":"span","marks":[],"text":"), AJMC.com, and The Center for Biosimilars","_key":"35b69a01dbbe"},{"_key":"8ddca200bc46","_type":"span","marks":["superscript"],"text":"®"},{"_type":"span","marks":[],"text":".","_key":"ba3cca6122e3"}],"_type":"block","style":"normal","_key":"3da8fced8696","markDefs":[]}],"showSocialShare":null,"displayName":"Cameron Santoro","firstName":"Cameron","lastName":"Santoro"}],"_id":"3ab0a249-35da-4929-895b-bc3bc50fe93c","factCheckBy":[{"biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Cameron Santoro is an associate editor for ","_key":"93662c5c4cfd"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"213c257c1eca"},{"marks":["superscript"],"text":"®","_key":"f546acb0aa91","_type":"span"},{"_type":"span","marks":[],"text":" (","_key":"acd931edd707"},{"text":"AJMC","_key":"843f7d4e787d","_type":"span","marks":["em"]},{"_key":"7c809e803edb","_type":"span","marks":["superscript"],"text":"®"},{"_type":"span","marks":[],"text":"), AJMC.com, and The Center for Biosimilars","_key":"35b69a01dbbe"},{"_key":"8ddca200bc46","_type":"span","marks":["superscript"],"text":"®"},{"_type":"span","marks":[],"text":".","_key":"ba3cca6122e3"}],"_type":"block","style":"normal","_key":"3da8fced8696"}],"showSocialShare":null,"displayName":"Cameron Santoro","firstName":"Cameron","lastName":"Santoro","url":{"current":"cameron-santoro","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Cameron Santoro","asset":{"_ref":"image-6ae51a61642a5ecba7cf4085fe97e68814e3c917-430x430-png","_type":"reference"}}}]},{"url":"recent-cohorts-aging-into-medicare-use-more-counseling-and-psychotherapy-than-past-cohorts","published":"2024-11-14T14:00:00.000Z","authorDetails":[{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Grace McCormack, PhD","firstName":"Grace","lastName":"McCormack","url":{"current":"grace-mccormack-phd","_type":"slug"}},{"url":{"current":"erin-l-duffy-phd-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Erin L. Duffy, PhD, MPH","firstName":"Erin","lastName":"Duffy"},{"showSocialShare":null,"displayName":"Adam Biener, PhD","firstName":"Adam","lastName":"Biener","url":{"current":"adam-biener-phd","_type":"slug"},"profileImage":null,"biography":null}],"factCheckBy":[{"firstName":"Grace","lastName":"McCormack","url":{"_type":"slug","current":"grace-mccormack-phd"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Grace McCormack, PhD"},{"showSocialShare":null,"displayName":"Erin L. Duffy, PhD, MPH","firstName":"Erin","lastName":"Duffy","url":{"current":"erin-l-duffy-phd-mph","_type":"slug"},"profileImage":null,"biography":null},{"displayName":"Adam Biener, PhD","firstName":"Adam","lastName":"Biener","url":{"current":"adam-biener-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null}],"thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"_createdAt":"2023-07-11T20:45:56Z","uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","size":203185,"mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","_updatedAt":"2023-07-11T20:45:56Z","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","metadata":{"_type":"sanity.imageMetadata","palette":{"darkMuted":{"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.71},"muted":{"background":"#628cad","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.38},"lightVibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.93,"background":"#cae1f2"},"darkVibrant":{"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.09},"lightMuted":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26,"background":"#9bb7cc"},"vibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.52,"background":"#18568d"},"dominant":{"population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"_type":"sanity.imagePalette"},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj"},"_type":"sanity.imageAsset","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png"}},"_id":"f5657fbb-1a24-4a40-b7dd-55b0c5bd2234","issueGroup":{"_ref":"3b0140fe-ebe5-450c-b4e4-9f7b3e0f41d3","_type":"reference"},"title":"Recent Cohorts Aging Into Medicare Use More Counseling and Psychotherapy Than Past Cohorts","summary":"Adults currently aging into Medicare utilized counseling and psychotherapy services at higher rates than those in prior cohorts at the same age."},{"issueGroup":{"_ref":"3b0140fe-ebe5-450c-b4e4-9f7b3e0f41d3","_type":"reference"},"url":"how-english--and-spanish-preferring-patients-with-cancer-decide-on-emergency-care","published":"2024-11-13T14:00:00.000Z","authorDetails":[{"showSocialShare":null,"displayName":"Arthur S. Hong, MD, MPH","firstName":"Arthur","lastName":"Hong","url":{"current":"arthur-s-hong-md-mph","_type":"slug"},"profileImage":null,"biography":null},{"displayName":"Beverly Kyalwazi, MD","firstName":"Beverly","lastName":"Kyalwazi","url":{"current":"beverly-kyalwazi-md","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"biography":null,"showSocialShare":null,"displayName":"Ethan A. Halm, MD, MPH, MBA","firstName":"Ethan","lastName":"Halm","url":{"_type":"slug","current":"ethan-a-halm-md-mph-mba"},"profileImage":null},{"displayName":"D. Mark Courtney, MD, MSCI","firstName":"D.","lastName":"Courtney","url":{"current":"d-mark-courtney-md-msci","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"displayName":"John W. Sweetenham, MD","firstName":"John","lastName":"Sweetenham","url":{"_type":"slug","current":"john-w-sweetenham-md"},"profileImage":null,"biography":null,"showSocialShare":null},{"firstName":"Navid","lastName":"Sadeghi","url":{"current":"navid-sadeghi-md","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Navid Sadeghi, MD, MSPH"},{"url":{"current":"john-v-cox-do-mba","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"John V. Cox, DO, MBA","firstName":"John","lastName":"Cox"},{"biography":null,"showSocialShare":null,"displayName":"Simon J. Craddock Lee, PhD, MPH","firstName":"Simon","lastName":"Craddock Lee","url":{"current":"simon-j-craddock-lee-phd-mph","_type":"slug"},"profileImage":null}],"factCheckBy":[{"showSocialShare":null,"displayName":"Arthur S. Hong, MD, MPH","firstName":"Arthur","lastName":"Hong","url":{"current":"arthur-s-hong-md-mph","_type":"slug"},"profileImage":null,"biography":null},{"biography":null,"showSocialShare":null,"displayName":"Beverly Kyalwazi, MD","firstName":"Beverly","lastName":"Kyalwazi","url":{"_type":"slug","current":"beverly-kyalwazi-md"},"profileImage":null},{"lastName":"Halm","url":{"current":"ethan-a-halm-md-mph-mba","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Ethan A. Halm, MD, MPH, MBA","firstName":"Ethan"},{"biography":null,"showSocialShare":null,"displayName":"D. Mark Courtney, MD, MSCI","firstName":"D.","lastName":"Courtney","url":{"current":"d-mark-courtney-md-msci","_type":"slug"},"profileImage":null},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"John W. Sweetenham, MD","firstName":"John","lastName":"Sweetenham","url":{"current":"john-w-sweetenham-md","_type":"slug"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Navid Sadeghi, MD, MSPH","firstName":"Navid","lastName":"Sadeghi","url":{"current":"navid-sadeghi-md","_type":"slug"}},{"firstName":"John","lastName":"Cox","url":{"current":"john-v-cox-do-mba","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"John V. Cox, DO, MBA"},{"lastName":"Craddock Lee","url":{"current":"simon-j-craddock-lee-phd-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Simon J. Craddock Lee, PhD, MPH","firstName":"Simon"}],"_id":"d99dde01-66cf-4191-8bad-05d431132d9f","summary":"Care delivery innovations to help patients with cancer avoid emergency department visits are underused. The authors interviewed English- and Spanish-preferring patients at 2 diverse health systems to understand why.","thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","_updatedAt":"2023-07-11T20:45:56Z","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","_type":"sanity.imageAsset","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"_type":"sanity.imageMetadata","palette":{"dominant":{"title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"_type":"sanity.imagePalette","darkMuted":{"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.71},"muted":{"foreground":"#fff","title":"#fff","population":0.38,"background":"#628cad","_type":"sanity.imagePaletteSwatch"},"lightVibrant":{"foreground":"#000","title":"#000","population":0.93,"background":"#cae1f2","_type":"sanity.imagePaletteSwatch"},"darkVibrant":{"title":"#fff","population":0.09,"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"vibrant":{"population":0.52,"background":"#18568d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"}},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj"},"uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z"}},"title":"How English- and Spanish-Preferring Patients With Cancer Decide on Emergency Care "},{"factCheckBy":[{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Sadiq Y. Patel, PhD, MS","firstName":"Sadiq","lastName":"Patel","url":{"current":"sadiq-y-patel-phd-ms","_type":"slug"}},{"firstName":"Aaron","lastName":"Baum","url":{"_type":"slug","current":"aaron-baum-phd"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Aaron Baum, PhD"},{"lastName":"Basu","url":{"current":"sanjay-basu-md-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Sanjay Basu, MD, PhD","firstName":"Sanjay"}],"_id":"404b320c-f480-4fc3-b080-8fa1dd562551","issueGroup":{"_ref":"3b0140fe-ebe5-450c-b4e4-9f7b3e0f41d3","_type":"reference"},"url":"geographic-variations-and-facility-determinants-of-acute-care-utilization-and-spending-for-acscs","published":"2024-11-12T14:00:00.000Z","title":"Geographic Variations and Facility Determinants of Acute Care Utilization and Spending for ACSCs","summary":"Emergency department (ED) visits and hospitalizations for ambulatory care–sensitive conditions (ACSCs) among Medicaid patients constitute almost 40% of all ED visits and hospitalizations, with lower rates observed in areas with greater proximity to urgent care facilities and density of rural health clinics.","thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","_updatedAt":"2023-07-11T20:45:56Z","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"palette":{"darkMuted":{"population":0.71,"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"muted":{"background":"#628cad","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.38},"lightVibrant":{"population":0.93,"background":"#cae1f2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000"},"darkVibrant":{"title":"#fff","population":0.09,"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"vibrant":{"background":"#18568d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.52},"dominant":{"foreground":"#000","title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch"},"_type":"sanity.imagePalette"},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj","_type":"sanity.imageMetadata"},"_type":"sanity.imageAsset","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6"}},"authorDetails":[{"showSocialShare":null,"displayName":"Sadiq Y. Patel, PhD, MS","firstName":"Sadiq","lastName":"Patel","url":{"current":"sadiq-y-patel-phd-ms","_type":"slug"},"profileImage":null,"biography":null},{"biography":null,"showSocialShare":null,"displayName":"Aaron Baum, PhD","firstName":"Aaron","lastName":"Baum","url":{"current":"aaron-baum-phd","_type":"slug"},"profileImage":null},{"firstName":"Sanjay","lastName":"Basu","url":{"current":"sanjay-basu-md-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Sanjay Basu, MD, PhD"}]},{"_id":"f46ba78f-9e25-4566-a21d-7f2d8013f43b","issueGroup":{"_ref":"f3dd603a-37be-46c5-a0ed-79c2e9f9a55d","_type":"reference"},"title":"Beyond McKesson and Florida Cancer Specialists, Deals Are Reshaping Community Oncology ","authorDetails":[{"biography":[{"style":"normal","_key":"80606b0b2412","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_key":"f56917041c08","_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for "},{"text":"Evidence-Based Oncology, ","_key":"8c710bb1d962","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for ","_key":"1b94f48924f3"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_key":"953d8c643cce","_type":"span","marks":["em"],"text":"AJMC"},{"_key":"182af2348b04","_type":"span","marks":[],"text":" readers. "}],"_type":"block"},{"style":"normal","_key":"a03d32973d6e","markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"_key":"9737335da1ed2","_type":"span","marks":[],"text":"."}],"_type":"block"}],"showSocialShare":null,"displayName":"Mary Caffrey","firstName":null,"lastName":null,"url":{"_type":"slug","current":"mary-caffrey"},"profileImage":null}],"factCheckBy":[{"biography":[{"style":"normal","_key":"80606b0b2412","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for ","_key":"f56917041c08"},{"_key":"8c710bb1d962","_type":"span","marks":["em"],"text":"Evidence-Based Oncology, "},{"_key":"1b94f48924f3","_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"953d8c643cce"},{"_type":"span","marks":[],"text":" readers. ","_key":"182af2348b04"}],"_type":"block"},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4"}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"text":".","_key":"9737335da1ed2","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"a03d32973d6e"}],"showSocialShare":null,"displayName":"Mary Caffrey","firstName":null,"lastName":null,"url":{"current":"mary-caffrey","_type":"slug"},"profileImage":null}],"summary":null,"thumbnail":{"alt":"Orange City ribbon-cutting | Image credit: FCS press release","caption":"Ribbon-cutting at new facility in Orange City for Florida Cancer Specialists \u0026 Research Institute in February 2024. | Image credit: FCS press release","asset":{"_type":"sanity.imageAsset","mimeType":"image/jpeg","_id":"image-4cc5fe49422965d25cd9df088a7f56d3a2de40b1-1200x628-jpg","metadata":{"hasAlpha":false,"lqip":"data:image/jpeg;base64,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","dimensions":{"width":1200,"aspectRatio":1.910828025477707,"height":628,"_type":"sanity.imageDimensions"},"isOpaque":true,"blurHash":"MkL:AbR5tQRPo}~AV@kDi^ozx^oet7WBW=","_type":"sanity.imageMetadata","palette":{"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":7.44,"background":"#8e7b63"},"lightVibrant":{"title":"#fff","population":0.36,"background":"#f58d57","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"darkVibrant":{"population":0.28,"background":"#714918","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightMuted":{"population":7.27,"background":"#c1a394","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"vibrant":{"title":"#fff","population":5.37,"background":"#e48c53","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"dominant":{"title":"#fff","population":7.44,"background":"#8e7b63","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"_type":"sanity.imagePalette","darkMuted":{"foreground":"#fff","title":"#fff","population":2.59,"background":"#4c3827","_type":"sanity.imagePaletteSwatch"}}},"url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/4cc5fe49422965d25cd9df088a7f56d3a2de40b1-1200x628.jpg","size":206688,"originalFilename":"Orange-City-Ribbon-Cutting-022724.jpg","uploadId":"i9vAHOJP6REIOEUWNlG2EiJ2k2uzm3nO","_rev":"l8hWsBDY1XE7uXNKgKoAse","extension":"jpg","sha1hash":"4cc5fe49422965d25cd9df088a7f56d3a2de40b1","path":"images/0vv8moc6/ajmc/4cc5fe49422965d25cd9df088a7f56d3a2de40b1-1200x628.jpg","assetId":"4cc5fe49422965d25cd9df088a7f56d3a2de40b1","_createdAt":"2024-10-25T13:47:39Z","_updatedAt":"2024-10-25T13:47:39Z"},"_type":"mainImage"},"url":"beyond-mckesson-and-florida-cancer-specialists-deals-are-reshaping-community-oncology","published":"2024-10-25T13:04:00.000Z"},{"issueGroup":{"_ref":"f9450ef8-d89e-4aaa-9fac-2b11c3a068fb","_type":"reference"},"url":"accountable-care-organizations-and-hpv-vaccine-uptake-a-multilevel-analysis","published":"2024-10-24T18:00:00.000Z","authorDetails":[{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Eileen J. Carter, PhD, RN","firstName":"Eileen","lastName":"Carter","url":{"current":"eileen-j-carter-phd-rn","_type":"slug"}},{"firstName":"Yuen Tsz","lastName":"Lau","url":{"current":"yuen-tsz-abby-lau-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Yuen Tsz Abby Lau, PhD"},{"biography":null,"showSocialShare":null,"displayName":"Laurel Buchanan, MA","firstName":"Laurel","lastName":"Buchanan","url":{"current":"laurel-buchanan-ma","_type":"slug"},"profileImage":null},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"David M. Krol, MD, MPH","firstName":"David","lastName":"Krol","url":{"current":"david-m-krol-md-mph","_type":"slug"}},{"showSocialShare":null,"displayName":"Jun Yan, PhD","firstName":"Jun","lastName":"Yan","url":{"current":"jun-yan-phd","_type":"slug"},"profileImage":null,"biography":null},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Robert H. Aseltine Jr, PhD","firstName":"Robert","lastName":"Aseltine","url":{"current":"robert-h-aseltine-jr-phd","_type":"slug"}}],"factCheckBy":[{"url":{"current":"eileen-j-carter-phd-rn","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Eileen J. Carter, PhD, RN","firstName":"Eileen","lastName":"Carter"},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Yuen Tsz Abby Lau, PhD","firstName":"Yuen Tsz","lastName":"Lau","url":{"current":"yuen-tsz-abby-lau-phd","_type":"slug"}},{"url":{"current":"laurel-buchanan-ma","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Laurel Buchanan, MA","firstName":"Laurel","lastName":"Buchanan"},{"url":{"current":"david-m-krol-md-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"David M. Krol, MD, MPH","firstName":"David","lastName":"Krol"},{"displayName":"Jun Yan, PhD","firstName":"Jun","lastName":"Yan","url":{"current":"jun-yan-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"showSocialShare":null,"displayName":"Robert H. Aseltine Jr, PhD","firstName":"Robert","lastName":"Aseltine","url":{"current":"robert-h-aseltine-jr-phd","_type":"slug"},"profileImage":null,"biography":null}],"_id":"444a4315-6531-40e0-845b-418d00ed04bb","title":"Accountable Care Organizations and HPV Vaccine Uptake: A Multilevel Analysis","summary":"The authors evaluated whether adolescents receiving care at accountable care organizations (ACOs) vs non-ACOs were more likely to initiate and complete the human papillomavirus (HPV) vaccination series.","thumbnail":{"_type":"mainImage","asset":{"uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","_updatedAt":"2023-07-11T20:45:56Z","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj","_type":"sanity.imageMetadata","palette":{"lightVibrant":{"background":"#cae1f2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.93},"darkVibrant":{"title":"#fff","population":0.09,"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"foreground":"#000","title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch"},"vibrant":{"foreground":"#fff","title":"#fff","population":0.52,"background":"#18568d","_type":"sanity.imagePaletteSwatch"},"dominant":{"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26},"_type":"sanity.imagePalette","darkMuted":{"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.71},"muted":{"title":"#fff","population":0.38,"background":"#628cad","_type":"sanity.imagePaletteSwatch","foreground":"#fff"}},"hasAlpha":true},"_type":"sanity.imageAsset"}}},{"factCheckBy":[{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Alexandra G. Hames, PhD","firstName":"Alexandra","lastName":"Hames","url":{"current":"alexandra-g-hames-phd","_type":"slug"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Renuka Tipirneni, MD, MSc","firstName":"Renuka","lastName":"Tipirneni","url":{"current":"renuka-tipirneni-md-msc","_type":"slug"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Galen E. Switzer, PhD","firstName":"Galen","lastName":"Switzer","url":{"current":"galen-e-switzer-phd","_type":"slug"}},{"displayName":"John Z. Ayanian, MD, MPP","firstName":"John","lastName":"Ayanian","url":{"current":"john-z-ayanian-md-mpp","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"lastName":"Kullgren","url":{"current":"jeffrey-t-kullgren-md-ms-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Jeffrey T. Kullgren, MD, MS, MPH","firstName":"Jeffrey"},{"displayName":"Erica Solway, PhD, MPH, MSW","firstName":"Erica","lastName":"Solway","url":{"current":"erica-solway-phd-mph-msw","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"showSocialShare":null,"displayName":"Eric T. Roberts, PhD","firstName":"Eric","lastName":"Roberts","url":{"_type":"slug","current":"eric-t-roberts-phd"},"profileImage":null,"biography":null}],"_id":"c797bf68-6f9e-4d02-9336-14c1800b8a24","issueGroup":{"_ref":"f9450ef8-d89e-4aaa-9fac-2b11c3a068fb","_type":"reference"},"title":"Racial/Ethnic Disparities in Cost-Related Barriers to Care Among Near-Poor Beneficiaries in Medicare Advantage vs Traditional Medicare","url":"racial-ethnic-disparities-in-cost-related-barriers-to-care-among-near-poor-beneficiaries-in-medicare-advantage-vs-traditional-medicare","authorDetails":[{"displayName":"Alexandra G. Hames, PhD","firstName":"Alexandra","lastName":"Hames","url":{"current":"alexandra-g-hames-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"firstName":"Renuka","lastName":"Tipirneni","url":{"current":"renuka-tipirneni-md-msc","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Renuka Tipirneni, MD, MSc"},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Galen E. Switzer, PhD","firstName":"Galen","lastName":"Switzer","url":{"current":"galen-e-switzer-phd","_type":"slug"}},{"firstName":"John","lastName":"Ayanian","url":{"current":"john-z-ayanian-md-mpp","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"John Z. Ayanian, MD, MPP"},{"displayName":"Jeffrey T. Kullgren, MD, MS, MPH","firstName":"Jeffrey","lastName":"Kullgren","url":{"current":"jeffrey-t-kullgren-md-ms-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"showSocialShare":null,"displayName":"Erica Solway, PhD, MPH, MSW","firstName":"Erica","lastName":"Solway","url":{"current":"erica-solway-phd-mph-msw","_type":"slug"},"profileImage":null,"biography":null},{"lastName":"Roberts","url":{"current":"eric-t-roberts-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Eric T. Roberts, PhD","firstName":"Eric"}],"summary":"Among near-poor Black and Hispanic individuals, Medicare Advantage was associated with increased vision care and some, although not uniform, reductions in access disparities vs traditional Medicare.","thumbnail":{"asset":{"sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj","_type":"sanity.imageMetadata","palette":{"vibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.52,"background":"#18568d"},"dominant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26,"background":"#9bb7cc"},"_type":"sanity.imagePalette","darkMuted":{"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.71},"muted":{"foreground":"#fff","title":"#fff","population":0.38,"background":"#628cad","_type":"sanity.imagePaletteSwatch"},"lightVibrant":{"population":0.93,"background":"#cae1f2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000"},"darkVibrant":{"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.09},"lightMuted":{"title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000"}}},"_type":"sanity.imageAsset","uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","_updatedAt":"2023-07-11T20:45:56Z","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png"},"_type":"mainImage","alt":"AJMC"},"published":"2024-10-23T14:00:11.540Z"},{"summary":"This article explores late-life relocations in patients with dementia, hospital stays, and their implications for health care policy, geriatric care, and future research priorities.","published":"2024-10-22T13:00:00.000Z","authorDetails":[{"firstName":"Reza","lastName":"Amini","url":{"current":"reza-amini-phd-md-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Reza Amini, PhD, MD, MPH"},{"biography":null,"showSocialShare":null,"displayName":"Azmat Sidhu, MPH","firstName":"Azmat","lastName":"Sidhu","url":{"current":"azmat-sidhu-mph","_type":"slug"},"profileImage":null}],"factCheckBy":[{"displayName":"Reza Amini, PhD, MD, MPH","firstName":"Reza","lastName":"Amini","url":{"current":"reza-amini-phd-md-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"firstName":"Azmat","lastName":"Sidhu","url":{"_type":"slug","current":"azmat-sidhu-mph"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Azmat Sidhu, MPH"}],"url":"hospital-stays-and-probable-dementia-as-predictors-of-relocation-to-long-term-care-facilities","_id":"0f3eca76-cd72-4e5c-b4bc-cdc6fe1cea34","issueGroup":{"_ref":"f9450ef8-d89e-4aaa-9fac-2b11c3a068fb","_type":"reference"},"title":"Hospital Stays and Probable Dementia as Predictors of Relocation to Long-Term Care Facilities","thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","_updatedAt":"2023-07-11T20:45:56Z","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj","_type":"sanity.imageMetadata","palette":{"dominant":{"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26},"_type":"sanity.imagePalette","darkMuted":{"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.71},"muted":{"population":0.38,"background":"#628cad","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightVibrant":{"foreground":"#000","title":"#000","population":0.93,"background":"#cae1f2","_type":"sanity.imagePaletteSwatch"},"darkVibrant":{"foreground":"#fff","title":"#fff","population":0.09,"background":"#044679","_type":"sanity.imagePaletteSwatch"},"lightMuted":{"title":"#fff","population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"vibrant":{"title":"#fff","population":0.52,"background":"#18568d","_type":"sanity.imagePaletteSwatch","foreground":"#fff"}}},"_type":"sanity.imageAsset","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6"}}},{"published":"2024-10-14T20:00:00.000Z","_id":"2fe4c86e-9756-4ef8-ab38-411834bb1a83","thumbnail":{"alt":"MinnOncology logo | Image: Minnesota Oncology","caption":"MinnOncology logo | Image: Minnesota Oncology","asset":{"_type":"sanity.imageAsset","sha1hash":"7d70f8513adc70c28ce0e147ba594bb572d73064","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/7d70f8513adc70c28ce0e147ba594bb572d73064-540x235.jpg","path":"images/0vv8moc6/ajmc/7d70f8513adc70c28ce0e147ba594bb572d73064-540x235.jpg","extension":"jpg","metadata":{"palette":{"muted":{"population":0.11,"background":"#8e9559","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightVibrant":{"background":"#9be8ee","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.38},"darkVibrant":{"population":0.21,"background":"#24475d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightMuted":{"title":"#000","population":0.1,"background":"#ccd3a1","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"vibrant":{"foreground":"#fff","title":"#fff","population":0.2,"background":"#0bb6ce","_type":"sanity.imagePaletteSwatch"},"dominant":{"population":0.47,"background":"#3f483a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"_type":"sanity.imagePalette","darkMuted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.47,"background":"#3f483a"}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,/9j/2wBDAAYEBQYFBAYGBQYHBwYIChAKCgkJChQODwwQFxQYGBcUFhYaHSUfGhsjHBYWICwgIyYnKSopGR8tMC0oMCUoKSj/2wBDAQcHBwoIChMKChMoGhYaKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCj/wAARCAAJABQDASIAAhEBAxEB/8QAGAAAAwEBAAAAAAAAAAAAAAAAAAQFAwj/xAAhEAABBAEEAwEAAAAAAAAAAAACAAEDBBEFITFxFDNDkf/EABUBAQEAAAAAAAAAAAAAAAAAAAID/8QAFxEAAwEAAAAAAAAAAAAAAAAAAAIRAf/aAAwDAQACEQMRAD8A6ee3kXzFILvtuym6MFmnJY8qUpmkLIYbhlR1H1D2lR5DtPFuEmeNB9rGfmf4hbIQKn//2Q==","dimensions":{"_type":"sanity.imageDimensions","width":540,"aspectRatio":2.297872340425532,"height":235},"isOpaque":true,"blurHash":"MFS6V%t8~Vxu9G^+j[x]j[D*%gofsooft6","_type":"sanity.imageMetadata"},"mimeType":"image/jpeg","assetId":"7d70f8513adc70c28ce0e147ba594bb572d73064","_createdAt":"2024-10-14T16:43:33Z","originalFilename":"minnesota-oncology.jpg","uploadId":"KFZplqb0QKaISRQVulrrZEj0ohzt8bwt","_rev":"KLVqzQL7KTVccOrMxma2pU","size":11001,"_id":"image-7d70f8513adc70c28ce0e147ba594bb572d73064-540x235-jpg","_updatedAt":"2024-10-14T16:43:33Z"},"_type":"mainImage"},"url":"the-daily-balancing-act-of-value-based-cancer-care","authorDetails":[{"firstName":"Laura","lastName":"Joszt","url":{"current":"laura-joszt","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Laura Joszt headshot","asset":{"_ref":"image-93ea362164e769dfd84dca31a8b2670a1dd9092b-512x512-jpg","_type":"reference"}},"biography":[{"markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"href":"https://twitter.com/joszt","_key":"c419f18a7ffe","_type":"link"}],"children":[{"_type":"span","marks":[],"text":"Laura is the vice president of content for The American Journal of Managed Care® (AJMC®) and all its brands, including The American Journal of Accountable Care®, Evidence-Based Oncology™, and The Center for Biosimilars®. She has been working on AJMC® since 2014 and has been with AJMC®’s parent company, MJH Life Sciences®, since 2011.","_key":"67a67d3764f00"}],"_type":"block","style":"normal","_key":"4a950aea97b3"},{"style":"normal","_key":"b28d8058b3d8","markDefs":[{"href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d","nofollow":true,"blank":true,"_type":"link"},{"nofollow":true,"blank":true,"_type":"link","href":"https://twitter.com/joszt","_key":"c419f18a7ffe"}],"children":[{"_type":"span","marks":[],"text":"She has an MA in business and economic reporting from New York University. You can connect with Laura on ","_key":"48d199d8ecd5"},{"text":"LinkedIn","_key":"67a67d3764f01","_type":"span","marks":["f77b28536a8d"]},{"marks":[],"text":" or ","_key":"67a67d3764f02","_type":"span"},{"_type":"span","marks":["c419f18a7ffe"],"text":"Twitter","_key":"67a67d3764f03"},{"_type":"span","marks":[],"text":".","_key":"67a67d3764f04"}],"_type":"block"}],"showSocialShare":true,"displayName":"Laura Joszt, MA"}],"factCheckBy":[{"lastName":"Joszt","url":{"current":"laura-joszt","_type":"slug"},"profileImage":{"alt":"Laura Joszt headshot","asset":{"_ref":"image-93ea362164e769dfd84dca31a8b2670a1dd9092b-512x512-jpg","_type":"reference"},"_type":"mainImage"},"biography":[{"style":"normal","_key":"4a950aea97b3","markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"_type":"link","href":"https://twitter.com/joszt","_key":"c419f18a7ffe"}],"children":[{"_type":"span","marks":[],"text":"Laura is the vice president of content for The American Journal of Managed Care® (AJMC®) and all its brands, including The American Journal of Accountable Care®, Evidence-Based Oncology™, and The Center for Biosimilars®. She has been working on AJMC® since 2014 and has been with AJMC®’s parent company, MJH Life Sciences®, since 2011.","_key":"67a67d3764f00"}],"_type":"block"},{"style":"normal","_key":"b28d8058b3d8","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"blank":true,"_type":"link","href":"https://twitter.com/joszt","_key":"c419f18a7ffe","nofollow":true}],"children":[{"text":"She has an MA in business and economic reporting from New York University. You can connect with Laura on ","_key":"48d199d8ecd5","_type":"span","marks":[]},{"_type":"span","marks":["f77b28536a8d"],"text":"LinkedIn","_key":"67a67d3764f01"},{"_type":"span","marks":[],"text":" or ","_key":"67a67d3764f02"},{"_type":"span","marks":["c419f18a7ffe"],"text":"Twitter","_key":"67a67d3764f03"},{"_type":"span","marks":[],"text":".","_key":"67a67d3764f04"}],"_type":"block"}],"showSocialShare":true,"displayName":"Laura Joszt, MA","firstName":"Laura"}],"issueGroup":{"_ref":"f3dd603a-37be-46c5-a0ed-79c2e9f9a55d","_type":"reference"},"title":"The Daily Balancing Act of Value-Based Cancer Care","summary":null},{"title":"Transforming Value-Based Oncology Care in an Evolving Therapeutic Landscape","summary":null,"thumbnail":{"_type":"mainImage","asset":{"path":"images/0vv8moc6/ajmc/b3c196af748f73352b08b68beb6bd7d1b1becb97-310x163.jpg","originalFilename":"fcs logo.jpg","_id":"image-b3c196af748f73352b08b68beb6bd7d1b1becb97-310x163-jpg","uploadId":"Cn0HwxWFv0Ec8KIymIMyyzBtesHXyLzB","_rev":"tCpUdDwaYfiJObLAq3Mq1j","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/b3c196af748f73352b08b68beb6bd7d1b1becb97-310x163.jpg","size":7531,"_createdAt":"2024-10-14T12:53:32Z","extension":"jpg","mimeType":"image/jpeg","sha1hash":"b3c196af748f73352b08b68beb6bd7d1b1becb97","_updatedAt":"2024-10-14T12:53:32Z","metadata":{"_type":"sanity.imageMetadata","palette":{"lightMuted":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":0.17,"background":"#caa7ae"},"vibrant":{"background":"#db1b41","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.03},"dominant":{"background":"#32424f","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.2},"_type":"sanity.imagePalette","darkMuted":{"title":"#fff","population":0.2,"background":"#32424f","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"muted":{"population":0.16,"background":"#886d76","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightVibrant":{"background":"#96e0f1","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.1},"darkVibrant":{"background":"#045ca4","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,/9j/2wBDAAYEBQYFBAYGBQYHBwYIChAKCgkJChQODwwQFxQYGBcUFhYaHSUfGhsjHBYWICwgIyYnKSopGR8tMC0oMCUoKSj/2wBDAQcHBwoIChMKChMoGhYaKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCj/wAARCAALABQDASIAAhEBAxEB/8QAGAAAAwEBAAAAAAAAAAAAAAAAAAMGBQj/xAAhEAACAgICAQUAAAAAAAAAAAABAgADBREEEhRBUVNhkf/EABUBAQEAAAAAAAAAAAAAAAAAAAAB/8QAFxEBAQEBAAAAAAAAAAAAAAAAABEhQf/aAAwDAQACEQMRAD8A6FoyOUbirYlIcuOwDKQR9GNGSyCjVlNQfW9bm/oRVlFTv2etS3uRLib1OXZjKK+q6aCuvUwlB4nH+FPyEUj/2Q==","dimensions":{"width":310,"aspectRatio":1.901840490797546,"height":163,"_type":"sanity.imageDimensions"},"isOpaque":true,"blurHash":"MTRfnKxuWCkCWCt7RjjZoejZ~poJoJjsoK"},"_type":"sanity.imageAsset","assetId":"b3c196af748f73352b08b68beb6bd7d1b1becb97"}},"authorDetails":[{"lastName":"McNulty","url":{"current":"rose-mcnulty","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Rose McNulty","asset":{"_ref":"image-8445b436ab605560bc20c7e9c6f4f60912e914df-430x430-png","_type":"reference"}},"biography":[{"_key":"3a2b873558e3","markDefs":[],"children":[{"text":"Rose is an associate editorial director at ","_key":"123612bd9b2b0","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"2cd28f20d2b9"},{"_type":"span","marks":["superscript"],"text":"®","_key":"032c8e723210"},{"_key":"e2d5625eae03","_type":"span","marks":[],"text":" ("},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3af109dc927a"},{"_type":"span","marks":["superscript"],"text":"®","_key":"1903cd426eb6"},{"_type":"span","marks":[],"text":").","_key":"688f269c2ad0"}],"_type":"block","style":"normal"},{"_key":"3a18842aed2b","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/rose-mcnulty-652a09126/","_key":"a1a427c7e90e"}],"children":[{"_type":"span","marks":[],"text":"She has a BA in journalism \u0026 media studies and Spanish from Rutgers University. You can connect with Rose on ","_key":"3abc796e3805"},{"_key":"123612bd9b2b1","_type":"span","marks":["a1a427c7e90e"],"text":"LinkedIn"},{"_type":"span","marks":[],"text":".","_key":"123612bd9b2b2"}],"_type":"block","style":"normal"}],"showSocialShare":null,"displayName":"Rose McNulty","firstName":"Rose"}],"factCheckBy":[{"displayName":"Rose McNulty","firstName":"Rose","lastName":"McNulty","url":{"current":"rose-mcnulty","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Rose McNulty","asset":{"_ref":"image-8445b436ab605560bc20c7e9c6f4f60912e914df-430x430-png","_type":"reference"}},"biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Rose is an associate editorial director at ","_key":"123612bd9b2b0"},{"text":"The American Journal of Managed Care","_key":"2cd28f20d2b9","_type":"span","marks":["em"]},{"_type":"span","marks":["superscript"],"text":"®","_key":"032c8e723210"},{"_type":"span","marks":[],"text":" (","_key":"e2d5625eae03"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3af109dc927a"},{"_type":"span","marks":["superscript"],"text":"®","_key":"1903cd426eb6"},{"marks":[],"text":").","_key":"688f269c2ad0","_type":"span"}],"_type":"block","style":"normal","_key":"3a2b873558e3"},{"style":"normal","_key":"3a18842aed2b","markDefs":[{"_key":"a1a427c7e90e","nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/rose-mcnulty-652a09126/"}],"children":[{"_type":"span","marks":[],"text":"She has a BA in journalism \u0026 media studies and Spanish from Rutgers University. You can connect with Rose on ","_key":"3abc796e3805"},{"_key":"123612bd9b2b1","_type":"span","marks":["a1a427c7e90e"],"text":"LinkedIn"},{"_type":"span","marks":[],"text":".","_key":"123612bd9b2b2"}],"_type":"block"}],"showSocialShare":null}],"_id":"ac700a43-4c32-49dd-81d3-c17f7eb1b5c2","issueGroup":{"_ref":"f3dd603a-37be-46c5-a0ed-79c2e9f9a55d","_type":"reference"},"url":"transforming-value-based-oncology-care-in-an-evolving-therapeutic-landscape","published":"2024-10-14T18:00:00.000Z"},{"summary":"The authors examine how insurer and patient out-of-pocket payments for advanced prostate cancer differ by drug and health plan type and describe the relationship between these payments and utilization.","thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"_type":"sanity.imageMetadata","palette":{"lightVibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.93,"background":"#cae1f2"},"darkVibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.09,"background":"#044679"},"lightMuted":{"population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"vibrant":{"population":0.52,"background":"#18568d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"dominant":{"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26},"_type":"sanity.imagePalette","darkMuted":{"population":0.71,"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.38,"background":"#628cad"}},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj"},"_type":"sanity.imageAsset","uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","_updatedAt":"2023-07-11T20:45:56Z","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png"}},"url":"systemic-treatments-for-advanced-prostate-cancer-relationship-between-health-insurance-plan-and-treatment-costs","authorDetails":[{"displayName":"Deborah R. Kaye, MD, MS","firstName":"Deborah","lastName":"Kaye","url":{"current":"deborah-r-kaye-md-ms","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"displayName":"Hui-Jie Lee, PhD","firstName":"Hui-Jie","lastName":"Lee","url":{"current":"hui-jie-lee-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Alexander Gordee, MA","firstName":"Alexander","lastName":"Gordee","url":{"current":"alexander-gordee-ma","_type":"slug"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Daniel J. George, MD","firstName":"Daniel","lastName":"George","url":{"current":"daniel-j-george-md","_type":"slug"}},{"showSocialShare":null,"displayName":"Charles D. Scales Jr, MD, MSHS","firstName":"Charles","lastName":"Scales","url":{"current":"charles-d-scales-jr-md-mshs","_type":"slug"},"profileImage":null,"biography":null},{"biography":null,"showSocialShare":null,"displayName":"Peter A. Ubel, MD","firstName":"Peter","lastName":"Ubel","url":{"current":"peter-a-ubel-md","_type":"slug"},"profileImage":null},{"showSocialShare":null,"displayName":"M. Kate Bundorf, PhD, MBA, MPH","firstName":"M.","lastName":"Bundorf","url":{"current":"m-kate-bundorf-phd-mba-mph","_type":"slug"},"profileImage":null,"biography":null}],"factCheckBy":[{"displayName":"Deborah R. Kaye, MD, MS","firstName":"Deborah","lastName":"Kaye","url":{"current":"deborah-r-kaye-md-ms","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"firstName":"Hui-Jie","lastName":"Lee","url":{"_type":"slug","current":"hui-jie-lee-phd"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Hui-Jie Lee, PhD"},{"biography":null,"showSocialShare":null,"displayName":"Alexander Gordee, MA","firstName":"Alexander","lastName":"Gordee","url":{"current":"alexander-gordee-ma","_type":"slug"},"profileImage":null},{"displayName":"Daniel J. George, MD","firstName":"Daniel","lastName":"George","url":{"current":"daniel-j-george-md","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"displayName":"Charles D. Scales Jr, MD, MSHS","firstName":"Charles","lastName":"Scales","url":{"current":"charles-d-scales-jr-md-mshs","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"biography":null,"showSocialShare":null,"displayName":"Peter A. Ubel, MD","firstName":"Peter","lastName":"Ubel","url":{"current":"peter-a-ubel-md","_type":"slug"},"profileImage":null},{"displayName":"M. Kate Bundorf, PhD, MBA, MPH","firstName":"M.","lastName":"Bundorf","url":{"_type":"slug","current":"m-kate-bundorf-phd-mba-mph"},"profileImage":null,"biography":null,"showSocialShare":null}],"_id":"d8777579-53e5-4e4f-a977-0e8f0c366418","issueGroup":{"_ref":"b8e3b82c-0452-4c4b-8ec4-c441a3a5bfb8","_type":"reference"},"title":"Systemic Treatments for Advanced Prostate Cancer: Relationship Between Health Insurance Plan and Treatment Costs","published":"2024-09-20T13:00:00.000Z"},{"title":"Care Transition Management and Patient Outcomes in Hospitalized Medicare Beneficiaries","summary":"Hospital care transition activity facilitates uptake of Medicare-reimbursed transitional care management, which is associated with lower spending and better patient outcomes.","thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","_updatedAt":"2023-07-11T20:45:56Z","originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","_type":"sanity.imageAsset","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj","_type":"sanity.imageMetadata","palette":{"darkMuted":{"population":0.71,"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"muted":{"background":"#628cad","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.38},"lightVibrant":{"population":0.93,"background":"#cae1f2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000"},"darkVibrant":{"title":"#fff","population":0.09,"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"population":1.26,"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"vibrant":{"background":"#18568d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.52},"dominant":{"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26},"_type":"sanity.imagePalette"},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382}}}},"authorDetails":[{"displayName":"Mariétou H. Ouayogodé, PhD","firstName":"Mariétou","lastName":"Ouayogodé","url":{"current":"marietou-h-ouayogode-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"displayName":"Brianna Hardy, BS","firstName":"Brianna","lastName":"Hardy","url":{"current":"brianna-hardy-bs","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"lastName":"Mullahy","url":{"current":"john-mullahy-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"John Mullahy, PhD","firstName":"John"},{"url":{"_type":"slug","current":"maureen-a-smith-md-phd-mph"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Maureen A. Smith, MD, PhD, MPH","firstName":"Maureen","lastName":"Smith"},{"firstName":"Ellen","lastName":"Meara","url":{"current":"ellen-meara-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Ellen Meara, PhD"}],"_id":"caac8d8b-f8a3-4614-8abe-abe358cfa806","issueGroup":{"_ref":"b8e3b82c-0452-4c4b-8ec4-c441a3a5bfb8","_type":"reference"},"url":"care-transition-management-and-patient-outcomes-in-hospitalized-medicare-beneficiaries","published":"2024-09-19T13:00:00.000Z","factCheckBy":[{"displayName":"Mariétou H. Ouayogodé, PhD","firstName":"Mariétou","lastName":"Ouayogodé","url":{"current":"marietou-h-ouayogode-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"biography":null,"showSocialShare":null,"displayName":"Brianna Hardy, BS","firstName":"Brianna","lastName":"Hardy","url":{"current":"brianna-hardy-bs","_type":"slug"},"profileImage":null},{"biography":null,"showSocialShare":null,"displayName":"John Mullahy, PhD","firstName":"John","lastName":"Mullahy","url":{"current":"john-mullahy-phd","_type":"slug"},"profileImage":null},{"displayName":"Maureen A. Smith, MD, PhD, MPH","firstName":"Maureen","lastName":"Smith","url":{"current":"maureen-a-smith-md-phd-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"showSocialShare":null,"displayName":"Ellen Meara, PhD","firstName":"Ellen","lastName":"Meara","url":{"_type":"slug","current":"ellen-meara-phd"},"profileImage":null,"biography":null}]},{"issueGroup":{"_ref":"b8e3b82c-0452-4c4b-8ec4-c441a3a5bfb8","_type":"reference"},"published":"2024-09-18T16:00:00.000Z","factCheckBy":[{"url":{"current":"megha-a-parikh-phd-ms","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Megha A. Parikh, PhD, MS","firstName":"Megha","lastName":"Parikh"},{"displayName":"Sabree C. Burbage, PharmD, MPH","firstName":"Sabree","lastName":"Burbage","url":{"current":"sabree-c-burbage-pharmd-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"showSocialShare":null,"displayName":"Meghan H. Gabriel, PhD","firstName":"Meghan","lastName":"Gabriel","url":{"current":"meghan-h-gabriel-phd","_type":"slug"},"profileImage":null,"biography":null},{"biography":null,"showSocialShare":null,"displayName":"Ben E. Shirley, BSPH","firstName":"Ben","lastName":"Shirley","url":{"current":"ben-e-shirley-bsph","_type":"slug"},"profileImage":null},{"displayName":"Patrick J. Campbell, PharmD, PhD","firstName":"Patrick","lastName":"Campbell","url":{"current":"patrick-j-campbell-pharmd-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null}],"thumbnail":{"_type":"mainImage","alt":"AJMC","asset":{"originalFilename":"AJMC_logo_NEW.png","_rev":"hiKH9HIKxNVM35TxYdonKh","mimeType":"image/png","path":"images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","_updatedAt":"2023-07-11T20:45:56Z","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png","extension":"png","metadata":{"_type":"sanity.imageMetadata","palette":{"darkMuted":{"background":"#37536a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.71},"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.38,"background":"#628cad"},"lightVibrant":{"background":"#cae1f2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":0.93},"darkVibrant":{"population":0.09,"background":"#044679","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightMuted":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26,"background":"#9bb7cc"},"vibrant":{"background":"#18568d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.52},"dominant":{"background":"#9bb7cc","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.26},"_type":"sanity.imagePalette"},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"width":778,"aspectRatio":2.0366492146596857,"height":382,"_type":"sanity.imageDimensions"},"exif":{"_type":"sanity.imageExifMetadata","PixelXDimension":778,"PixelYDimension":382},"isOpaque":true,"blurHash":"MQRfnMfl?Ht7%LxvofofWBWC~pofE1t6Rj"},"_type":"sanity.imageAsset","sha1hash":"5421358c8f117ee86126333e135f08cf1e61ded6","uploadId":"HVdJn1r9v3RWlQCGbYP2dDQdFL6PajVT","_createdAt":"2023-07-11T20:45:56Z","size":203185,"assetId":"5421358c8f117ee86126333e135f08cf1e61ded6","_id":"image-5421358c8f117ee86126333e135f08cf1e61ded6-778x382-png"}},"url":"copd-treatment-ratio-a-measure-for-improving-copd-population-health","authorDetails":[{"showSocialShare":null,"displayName":"Megha A. Parikh, PhD, MS","firstName":"Megha","lastName":"Parikh","url":{"current":"megha-a-parikh-phd-ms","_type":"slug"},"profileImage":null,"biography":null},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Sabree C. Burbage, PharmD, MPH","firstName":"Sabree","lastName":"Burbage","url":{"current":"sabree-c-burbage-pharmd-mph","_type":"slug"}},{"displayName":"Meghan H. Gabriel, PhD","firstName":"Meghan","lastName":"Gabriel","url":{"current":"meghan-h-gabriel-phd","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"showSocialShare":null,"displayName":"Ben E. Shirley, BSPH","firstName":"Ben","lastName":"Shirley","url":{"current":"ben-e-shirley-bsph","_type":"slug"},"profileImage":null,"biography":null},{"firstName":"Patrick","lastName":"Campbell","url":{"_type":"slug","current":"patrick-j-campbell-pharmd-phd"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Patrick J. Campbell, PharmD, PhD"}],"_id":"53f2a80a-ab08-4863-9f67-14a3c7903a0d","title":"COPD Treatment Ratio: A Measure for Improving COPD Population Health","summary":"This article supports the use of the chronic obstructive pulmonary disease (COPD) treatment ratio as a surrogate marker of COPD exacerbation risk for quality measurement purposes."},{"_id":"04159ba8-44f9-40b5-b25f-0ae627881e39","title":"Healthy State: Practicing What They Preach in Louisiana","summary":"An IVBM event cohosted by The American Journal of Managed Care focused on Healthy State, a multiyear, multistakeholder commitment to moving Louisiana ahead in America’s Health Rankings.","published":"2024-09-16T16:31:55.211Z","authorDetails":[{"url":{"current":"mary-k-caffrey","_type":"slug"},"profileImage":{"default":false,"_type":"mainImage","alt":"Mary K. Caffrey","asset":{"_ref":"image-ed06a2c91900970a850116ba649d9f9b4a954ca5-430x430-png","_type":"reference"}},"biography":null,"showSocialShare":null,"displayName":"Mary K. Caffrey","firstName":null,"lastName":null}],"factCheckBy":[{"url":{"current":"mary-k-caffrey","_type":"slug"},"profileImage":{"default":false,"_type":"mainImage","alt":"Mary K. Caffrey","asset":{"_ref":"image-ed06a2c91900970a850116ba649d9f9b4a954ca5-430x430-png","_type":"reference"}},"biography":null,"showSocialShare":null,"displayName":"Mary K. Caffrey","firstName":null,"lastName":null}],"issueGroup":{"_ref":"73c988a3-a73b-49fa-af49-dce7e755e713","_type":"reference"},"thumbnail":{"asset":{"extension":"jpg","title":null,"uploadId":"kH1bS8OTS7iWFNmOt3qixxFUDmuSmj11","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/29b0fbb8f7b48c24276a1a8a300c1168e50e8707-2800x1867.jpg","opt":{"media":{"tags":null}},"_createdAt":"2024-08-28T16:07:24Z","originalFilename":"New Orleans Bourbon Street - f11photo - AdobeStock_169182961.jpeg","altText":null,"mimeType":"image/jpeg","path":"images/0vv8moc6/ajmc/29b0fbb8f7b48c24276a1a8a300c1168e50e8707-2800x1867.jpg","size":4265557,"assetId":"29b0fbb8f7b48c24276a1a8a300c1168e50e8707","_updatedAt":"2024-08-28T16:07:46Z","metadata":{"exif":{"FocalLengthIn35mmFormat":42,"FocalPlaneXResolution":2164.4328018223237,"WhiteBalance":0,"Sharpness":0,"DigitalZoomRatio":1,"ExposureBiasValue":0,"CustomRendered":0,"FNumber":5.6,"ExposureTime":2,"MaxApertureValue":4,"LightSource":0,"FocalPlaneYResolution":2164.4328018223237,"SceneCaptureType":0,"ExposureProgram":1,"SensitivityType":2,"RecommendedExposureIndex":100,"ISO":100,"ShutterSpeedValue":-1,"_type":"sanity.imageExifMetadata","Contrast":0,"PixelYDimension":1867,"FocalPlaneResolutionUnit":3,"PixelXDimension":2800,"LensSpecification":[16,35,4,4],"DateTimeDigitized":null,"BrightnessValue":-0.89296875,"ColorSpace":1,"LensModel":"16-35mm F4 G SSM OSS","ApertureValue":4.970853658536585,"MeteringMode":5,"Saturation":2,"DateTimeOriginal":"2016-11-15T06:32:19.000Z","ExposureMode":1,"FocalLength":28},"isOpaque":true,"blurHash":"VLKJoRB?^vPDoi765Ev|$*$x~W-poztRR-%#x]SxNyt7","_type":"sanity.imageMetadata","palette":{"_type":"sanity.imagePalette","darkMuted":{"background":"#2e3d58","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":2.99},"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":5.22,"background":"#976e64"},"lightVibrant":{"title":"#000","population":6.13,"background":"#f6d770","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"darkVibrant":{"title":"#fff","population":6.13,"background":"#935917","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"population":0.06,"background":"#b6a9cd","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"vibrant":{"title":"#fff","population":5.95,"background":"#efa11f","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"dominant":{"foreground":"#000","title":"#000","population":6.13,"background":"#f6d770","_type":"sanity.imagePaletteSwatch"}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":2800,"aspectRatio":1.4997321906802357,"height":1867}},"_rev":"LtkInV1jlQdtEIFjVqjDMg","_type":"sanity.imageAsset","description":null,"sha1hash":"29b0fbb8f7b48c24276a1a8a300c1168e50e8707","_id":"image-29b0fbb8f7b48c24276a1a8a300c1168e50e8707-2800x1867-jpg"},"_type":"mainImage","alt":"New Orleans Bourbon Street | Image Credit: © f11photo - stock.adobe.com"},"url":"healthy-state-practicing-what-they-preach-in-louisiana"},{"authorDetails":[{"profileImage":{"_type":"mainImage","alt":"Christina Mattina","asset":{"_ref":"image-6304e08858dcb7b689cd8fa5703c926a96ecdb48-512x492-jpg","_type":"reference"}},"biography":[{"style":"normal","_key":"9271b97a8f45","markDefs":[],"children":[{"marks":[],"text":"Christina is the associate editorial director of ","_key":"ffac76b64934","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"4eac35f29678"},{"marks":["superscript"],"text":"®","_key":"b16316585120","_type":"span"},{"_key":"ed200dc9139a","_type":"span","marks":[],"text":" ("},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b773bee92455"},{"text":"®","_key":"1f9bb13b24fa","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":") and ","_key":"b9461d308bc8"},{"marks":["em"],"text":"The American Journal of Accountable Care","_key":"f235dc7df490","_type":"span"},{"_key":"14118ee858d3","_type":"span","marks":["superscript"],"text":"®"},{"_type":"span","marks":[],"text":" (","_key":"a25757970c62"},{"text":"AJAC","_key":"6353c3a02e0f","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":"), and joined ","_key":"7f777b20be12"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"682a0f2ea0d4"},{"_type":"span","marks":[],"text":" in 2016. She oversees the publication of the print journals, from manuscript submission to publication, and works with the editors in chief and editorial boards to promote the journals.","_key":"8b1f00d70d7f"}],"_type":"block"},{"_type":"block","style":"normal","_key":"a90d7ab4c801","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/christinamattina/","_key":"c281c6aba22d"}],"children":[{"text":"She has a BS in public health from Rutgers University. You can connect with Christina on ","_key":"6d8dca7834cc","_type":"span","marks":[]},{"marks":["c281c6aba22d"],"text":"LinkedIn","_key":"e23534b48658","_type":"span"},{"_type":"span","marks":[],"text":".","_key":"83d100c64d0e"}]}],"showSocialShare":null,"displayName":"Christina Mattina","firstName":"Christina","lastName":"Mattina","url":{"current":"christina-mattina","_type":"slug"}}],"factCheckBy":[{"url":{"current":"christina-mattina","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Christina Mattina","asset":{"_ref":"image-6304e08858dcb7b689cd8fa5703c926a96ecdb48-512x492-jpg","_type":"reference"}},"biography":[{"_type":"block","style":"normal","_key":"9271b97a8f45","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Christina is the associate editorial director of ","_key":"ffac76b64934"},{"marks":["em"],"text":"The American Journal of Managed Care","_key":"4eac35f29678","_type":"span"},{"_type":"span","marks":["superscript"],"text":"®","_key":"b16316585120"},{"_key":"ed200dc9139a","_type":"span","marks":[],"text":" ("},{"_key":"b773bee92455","_type":"span","marks":["em"],"text":"AJMC"},{"_key":"1f9bb13b24fa","_type":"span","marks":["superscript"],"text":"®"},{"_type":"span","marks":[],"text":") and ","_key":"b9461d308bc8"},{"_type":"span","marks":["em"],"text":"The American Journal of Accountable Care","_key":"f235dc7df490"},{"_type":"span","marks":["superscript"],"text":"®","_key":"14118ee858d3"},{"_type":"span","marks":[],"text":" (","_key":"a25757970c62"},{"text":"AJAC","_key":"6353c3a02e0f","_type":"span","marks":["em"]},{"marks":[],"text":"), and joined ","_key":"7f777b20be12","_type":"span"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"682a0f2ea0d4"},{"_type":"span","marks":[],"text":" in 2016. She oversees the publication of the print journals, from manuscript submission to publication, and works with the editors in chief and editorial boards to promote the journals.","_key":"8b1f00d70d7f"}]},{"style":"normal","_key":"a90d7ab4c801","markDefs":[{"blank":true,"_type":"link","href":"https://www.linkedin.com/in/christinamattina/","_key":"c281c6aba22d","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"She has a BS in public health from Rutgers University. You can connect with Christina on ","_key":"6d8dca7834cc"},{"_type":"span","marks":["c281c6aba22d"],"text":"LinkedIn","_key":"e23534b48658"},{"_type":"span","marks":[],"text":".","_key":"83d100c64d0e"}],"_type":"block"}],"showSocialShare":null,"displayName":"Christina Mattina","firstName":"Christina","lastName":"Mattina"}],"_id":"2a95bae0-0c9f-4bc1-8e7d-3602ac803646","title":"Institute for Value-Based Medicine®: Multifaceted Approach Can Help Patients Benefit From the Expanded Lipid-Lowering Toolbox","summary":"Clinicians, researchers, and payer experts convened in Aurora, Colorado, on August 13, 2024, for discussions on ensuring that the recent advancements in lipid management are making their way to patients.","thumbnail":{"_type":"mainImage","alt":"Denver Colorado | Image Credit: © f11photo - stock.adobe.com","asset":{"uploadId":"H7WTao1JKvhWv1JBicLCJENbGPV6jpQH","_rev":"WVB52uR738qojYGNKmrerb","metadata":{"lqip":"data:image/jpeg;base64,/9j/2wBDAAYEBQYFBAYGBQYHBwYIChAKCgkJChQODwwQFxQYGBcUFhYaHSUfGhsjHBYWICwgIyYnKSopGR8tMC0oMCUoKSj/2wBDAQcHBwoIChMKChMoGhYaKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCj/wAARCAAMABQDASIAAhEBAxEB/8QAGAAAAgMAAAAAAAAAAAAAAAAAAAcCBAX/xAAfEAACAgICAwEAAAAAAAAAAAABAgADBBEGEiExYQX/xAAWAQEBAQAAAAAAAAAAAAAAAAACAwT/xAAdEQABBAIDAAAAAAAAAAAAAAADAAECEQQxBRJB/9oADAMBAAIRAxEAPwCeBhfnUkd7arNe+reptUZ/HVcV2voiKx8m2mtTWQCfgly3NtZEdhWWHgHqJI3InaVstA4C6aTkqyOIJWvfKRSRvREImxc7gMx8n5CBs83qLxhel//Z","dimensions":{"width":1200,"aspectRatio":1.7142857142857142,"height":700,"_type":"sanity.imageDimensions"},"exif":{"PixelYDimension":700,"_type":"sanity.imageExifMetadata","DateTimeDigitized":"2014-09-12T07:37:33.000Z","ColorSpace":1,"PixelXDimension":1200},"isOpaque":true,"blurHash":"MjHx1~IoS$S4oL%QRijZWrbH9vocWAoffP","_type":"sanity.imageMetadata","palette":{"darkMuted":{"background":"#4f4e2c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":6.64},"muted":{"population":4.67,"background":"#50659b","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightVibrant":{"foreground":"#000","title":"#000","population":0.31,"background":"#e9cf8d","_type":"sanity.imagePaletteSwatch"},"darkVibrant":{"title":"#fff","population":0.56,"background":"#544d07","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"title":"#fff","population":2.17,"background":"#a2a7c8","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"vibrant":{"title":"#fff","population":1.42,"background":"#ca762d","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"dominant":{"population":6.64,"background":"#4f4e2c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"_type":"sanity.imagePalette"},"hasAlpha":false},"sha1hash":"c2b2ded664a1fbdc0483dd96d0b7deae84831a7b","path":"images/0vv8moc6/ajmc/c2b2ded664a1fbdc0483dd96d0b7deae84831a7b-1200x700.jpg","_updatedAt":"2024-09-13T18:14:54Z","_type":"sanity.imageAsset","mimeType":"image/jpeg","_id":"image-c2b2ded664a1fbdc0483dd96d0b7deae84831a7b-1200x700-jpg","originalFilename":"Denver Colorado - f11photo - stock.adobe.com.jpeg","extension":"jpg","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/c2b2ded664a1fbdc0483dd96d0b7deae84831a7b-1200x700.jpg","size":584915,"assetId":"c2b2ded664a1fbdc0483dd96d0b7deae84831a7b","_createdAt":"2024-09-13T18:14:54Z"}},"url":"multifaceted-approach-can-help-patients-benefit-from-the-expanded-lipid-lowering-toolbox","published":"2024-09-16T16:31:18.436Z","issueGroup":{"_ref":"73c988a3-a73b-49fa-af49-dce7e755e713","_type":"reference"}},{"thumbnail":{"_type":"mainImage","alt":"telemedicine | Image Credit: © rh2010 - stock.adobe.com","asset":{"_type":"sanity.imageAsset","path":"images/0vv8moc6/ajmc/aa55cba013e542363db5e3021a7d049b005c0d44-7360x4912.jpg","_createdAt":"2023-12-05T16:28:07Z","metadata":{"hasAlpha":false,"lqip":"data:image/jpeg;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":7360,"aspectRatio":1.498371335504886,"height":4912},"isOpaque":true,"blurHash":"VEDl=,D%4n?c-;_N%M-pD%xvM{-;_3DiWBt7xax]t7M{","_type":"sanity.imageMetadata","palette":{"darkVibrant":{"background":"#493a1a","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":6.07},"lightMuted":{"background":"#bbbcbe","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":6.95},"vibrant":{"population":0.01,"background":"#ba825c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"dominant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":6.95,"background":"#bbbcbe"},"_type":"sanity.imagePalette","darkMuted":{"population":6.82,"background":"#61553c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"muted":{"background":"#b4745c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0},"lightVibrant":{"foreground":"#000","title":"#000","population":0.05,"background":"#e7d1c6","_type":"sanity.imagePaletteSwatch"}}},"_rev":"yLkPQ1Yunv4gUqVh5QBQaa","_id":"image-aa55cba013e542363db5e3021a7d049b005c0d44-7360x4912-jpg","originalFilename":"telemedicine - rh2010.jpeg","_updatedAt":"2023-12-05T16:28:07Z","extension":"jpg","uploadId":"ueKegQc9OLg07IP1riXXhgBAywYfiVMU","mimeType":"image/jpeg","sha1hash":"aa55cba013e542363db5e3021a7d049b005c0d44","assetId":"aa55cba013e542363db5e3021a7d049b005c0d44","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/aa55cba013e542363db5e3021a7d049b005c0d44-7360x4912.jpg","size":10640408}},"_id":"336a74f6-937d-40c6-a94c-b14c26f025f6","title":"Telehealth Insights From an Integrated Care System","summary":"Experiences from a large, integrated, value-based health system suggest that telehealth can be an effective care delivery approach. Public policies can improve telehealth access and care.","authorDetails":[{"firstName":"Rebecca","lastName":"Flournoy","url":{"current":"rebecca-flournoy-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Rebecca Flournoy, MPH"},{"displayName":"Reema Shah, MPH","firstName":"Reema","lastName":"Shah","url":{"current":"reema-shah-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null},{"url":{"current":"elizabeth-moisan-ms","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Elizabeth Moisan, MS","firstName":"Elizabeth","lastName":"Moisan"},{"displayName":"Cecilia Oregón, MPP, MPH","firstName":"Cecilia","lastName":"Oregón","url":{"current":"cecilia-oreg-n-mpp-mph","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null}],"factCheckBy":[{"showSocialShare":null,"displayName":"Rebecca Flournoy, MPH","firstName":"Rebecca","lastName":"Flournoy","url":{"current":"rebecca-flournoy-mph","_type":"slug"},"profileImage":null,"biography":null},{"displayName":"Reema Shah, MPH","firstName":"Reema","lastName":"Shah","url":{"_type":"slug","current":"reema-shah-mph"},"profileImage":null,"biography":null,"showSocialShare":null},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Elizabeth Moisan, MS","firstName":"Elizabeth","lastName":"Moisan","url":{"_type":"slug","current":"elizabeth-moisan-ms"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Cecilia Oregón, MPP, MPH","firstName":"Cecilia","lastName":"Oregón","url":{"current":"cecilia-oreg-n-mpp-mph","_type":"slug"}}],"issueGroup":{"_ref":"73c988a3-a73b-49fa-af49-dce7e755e713","_type":"reference"},"url":"telehealth-insights-from-an-integrated-care-system","published":"2024-09-16T16:29:41.215Z"},{"factCheckBy":[{"profileImage":null,"biography":[{"_type":"block","style":"normal","_key":"80606b0b2412","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for ","_key":"f56917041c08"},{"_key":"8c710bb1d962","_type":"span","marks":["em"],"text":"Evidence-Based Oncology, "},{"_key":"1b94f48924f3","_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"953d8c643cce"},{"_type":"span","marks":[],"text":" readers. ","_key":"182af2348b04"}]},{"_key":"a03d32973d6e","markDefs":[{"href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"text":".","_key":"9737335da1ed2","_type":"span","marks":[]}],"_type":"block","style":"normal"}],"showSocialShare":null,"displayName":"Mary Caffrey","firstName":null,"lastName":null,"url":{"current":"mary-caffrey","_type":"slug"}}],"_id":"f8b60efe-f6db-4fc2-a830-b561053d4e91","thumbnail":{"asset":{"extension":"jpg","uploadId":"2MwogAhJjfoY4HPFZ5xFzgjlENqac6KT","_type":"sanity.imageAsset","originalFilename":"telemedicine.jpeg","metadata":{"isOpaque":true,"blurHash":"VLLXb^Dh.9?bD%_4%gIUM_jZD%NG%MR*bb?cR*flo#t8","_type":"sanity.imageMetadata","palette":{"darkVibrant":{"background":"#6e5434","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":6.19},"lightMuted":{"foreground":"#000","title":"#fff","population":2.7,"background":"#c4b7a8","_type":"sanity.imagePaletteSwatch"},"vibrant":{"title":"#fff","population":0.01,"background":"#bc8e62","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"dominant":{"title":"#fff","population":7.7,"background":"#3e321f","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"_type":"sanity.imagePalette","darkMuted":{"population":7.7,"background":"#3e321f","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"muted":{"background":"#945c5c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.01},"lightVibrant":{"population":0,"background":"#d7bca2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":5928,"aspectRatio":1.5,"height":3952}},"_rev":"wjCpg6dpTOIsmpmsT5C0z0","size":1146957,"assetId":"ff16c42fb864c9e25a3c3f95ebe8c2519c41fc88","_id":"image-ff16c42fb864c9e25a3c3f95ebe8c2519c41fc88-5928x3952-jpg","mimeType":"image/jpeg","sha1hash":"ff16c42fb864c9e25a3c3f95ebe8c2519c41fc88","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/ff16c42fb864c9e25a3c3f95ebe8c2519c41fc88-5928x3952.jpg","path":"images/0vv8moc6/ajmc/ff16c42fb864c9e25a3c3f95ebe8c2519c41fc88-5928x3952.jpg","_createdAt":"2024-08-19T18:07:41Z","_updatedAt":"2024-08-19T18:07:41Z"},"_type":"mainImage","alt":"Nurse offering virtual visit | Image credit: Pexels/ Tima Miroshnichenko","caption":"Nurse offering virtual visit | Image credit: Pexels/ Tima Miroshnichenko"},"published":"2024-08-19T16:19:00.000Z","authorDetails":[{"profileImage":null,"biography":[{"style":"normal","_key":"80606b0b2412","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_key":"f56917041c08","_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for "},{"text":"Evidence-Based Oncology, ","_key":"8c710bb1d962","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for ","_key":"1b94f48924f3"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_key":"953d8c643cce","_type":"span","marks":["em"],"text":"AJMC"},{"_key":"182af2348b04","_type":"span","marks":[],"text":" readers. "}],"_type":"block"},{"_key":"a03d32973d6e","markDefs":[{"blank":true,"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"_key":"9737335da1ed2","_type":"span","marks":[],"text":"."}],"_type":"block","style":"normal"}],"showSocialShare":null,"displayName":"Mary Caffrey","firstName":null,"lastName":null,"url":{"_type":"slug","current":"mary-caffrey"}}],"issueGroup":{"_ref":"8f469cb0-5c36-4eaf-ab0e-2a34a0c7bf53","_type":"reference"},"title":"Building a Virtual Model for Care After Cancer","summary":null,"url":"building-a-virtual-model-for-care-after-cancer"},{"_id":"eaa4797e-cc0e-4b10-b3c5-169ea3739552","thumbnail":{"_type":"mainImage","alt":"COA seal | Image : COA","asset":{"_rev":"sgy4yN0CjmArmRDnE4d79D","_type":"sanity.imageAsset","metadata":{"dimensions":{"width":602,"aspectRatio":1,"height":602,"_type":"sanity.imageDimensions"},"isOpaque":false,"blurHash":"eBK9_:sp2@XSI8jGkWWUMdjb1HWV_#VsQmR+rrRPt,t7ptj@HXbF6-","_type":"sanity.imageMetadata","palette":{"vibrant":{"title":"#fff","population":19.15,"background":"#e31934","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"dominant":{"foreground":"#fff","title":"#fff","population":19.23,"background":"#143c8c","_type":"sanity.imagePaletteSwatch"},"_type":"sanity.imagePalette","darkMuted":{"background":"#293653","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":1.07},"muted":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.42,"background":"#54719f"},"lightVibrant":{"population":0.07,"background":"#fa84a0","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"darkVibrant":{"population":19.23,"background":"#143c8c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightMuted":{"background":"#a0acc0","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":3.12}},"hasAlpha":true,"lqip":"data:image/png;base64,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"},"uploadId":"55Ghe83hpIc18afc6jZj9tvxmCfNsnZ7","path":"images/0vv8moc6/ajmc/17ee076fc9d3da91dfa9c86f1e4048fa882b29eb-602x602.png","size":89027,"assetId":"17ee076fc9d3da91dfa9c86f1e4048fa882b29eb","_createdAt":"2024-05-21T20:44:39Z","_id":"image-17ee076fc9d3da91dfa9c86f1e4048fa882b29eb-602x602-png","_updatedAt":"2024-05-21T20:44:39Z","extension":"png","mimeType":"image/png","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/17ee076fc9d3da91dfa9c86f1e4048fa882b29eb-602x602.png","originalFilename":"COA_seal_2019-4C.png","sha1hash":"17ee076fc9d3da91dfa9c86f1e4048fa882b29eb"}},"url":"revised-eom-offers-more-favorable-opportunities-for-community-practices-experts-say","published":"2024-08-16T17:21:00.000Z","authorDetails":[{"url":{"_type":"slug","current":"mary-caffrey"},"profileImage":null,"biography":[{"_key":"80606b0b2412","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_key":"f56917041c08","_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for "},{"text":"Evidence-Based Oncology, ","_key":"8c710bb1d962","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for ","_key":"1b94f48924f3"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_key":"953d8c643cce","_type":"span","marks":["em"],"text":"AJMC"},{"_key":"182af2348b04","_type":"span","marks":[],"text":" readers. "}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"a03d32973d6e","markDefs":[{"blank":true,"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"_key":"9737335da1ed2","_type":"span","marks":[],"text":"."}]}],"showSocialShare":null,"displayName":"Mary Caffrey","firstName":null,"lastName":null}],"factCheckBy":[{"firstName":null,"lastName":null,"url":{"current":"mary-caffrey","_type":"slug"},"profileImage":null,"biography":[{"style":"normal","_key":"80606b0b2412","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"_type":"span","marks":[],"text":"®). She joined AJMC® in 2013 and is the primary staff editor for ","_key":"f56917041c08"},{"_key":"8c710bb1d962","_type":"span","marks":["em"],"text":"Evidence-Based Oncology, "},{"_key":"1b94f48924f3","_type":"span","marks":[],"text":"the multistakeholder publication that reaches 22,000+ oncology providers, policy makers and formulary decision makers. She is also part of the team that oversees speaker recruitment and panel preparations for "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3c5f9805f644"},{"_type":"span","marks":[],"text":"®'s premier annual oncology meeting, Patient-Centered Oncology Care®. For more than a decade, Mary has covered ASCO, ASH, ACC and other leading scientific meetings for ","_key":"d533ba55a862"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"953d8c643cce"},{"_type":"span","marks":[],"text":" readers. ","_key":"182af2348b04"}],"_type":"block"},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/marykcaffrey/","_key":"4f88673cb2c4"}],"children":[{"_type":"span","marks":[],"text":"Mary has a BA in communications and philosophy from Loyola University New Orleans. You can connect with Mary on ","_key":"c2027cf5a357"},{"_type":"span","marks":["4f88673cb2c4"],"text":"LinkedIn","_key":"9737335da1ed1"},{"text":".","_key":"9737335da1ed2","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"a03d32973d6e"}],"showSocialShare":null,"displayName":"Mary Caffrey"}],"issueGroup":{"_type":"reference","_ref":"8f469cb0-5c36-4eaf-ab0e-2a34a0c7bf53"},"title":"Revised EOM Offers More Favorable Opportunities for Community Practices, Experts Say","summary":null},{"_id":"77701ccb-39e1-4b49-ac6b-b5aa65801a00","title":"Collaborative Innovation: Flatiron Health and Canopy Partner to Streamline Continuous Care for Oncology Practices","thumbnail":{"_type":"mainImage","alt":"Flatiron + Canopy logo | Image: Canopy","caption":"Flatiron + Canopy logo | Image: Canopy","asset":{"extension":"png","_type":"sanity.imageAsset","size":930539,"_createdAt":"2024-08-16T11:54:45Z","metadata":{"_type":"sanity.imageMetadata","palette":{"darkMuted":{"population":0.44,"background":"#465281","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"muted":{"population":0.1,"background":"#5e599d","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightVibrant":{"title":"#000","population":0.03,"background":"#d5d4fc","_type":"sanity.imagePaletteSwatch","foreground":"#000"},"darkVibrant":{"foreground":"#fff","title":"#fff","population":0.01,"background":"#041c71","_type":"sanity.imagePaletteSwatch"},"lightMuted":{"background":"#a4afd8","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":0.58},"vibrant":{"background":"#1c2c84","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":42.73},"dominant":{"title":"#fff","population":42.73,"background":"#1c2c84","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"_type":"sanity.imagePalette"},"hasAlpha":true,"lqip":"data:image/png;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":2048,"aspectRatio":2.7750677506775068,"height":738},"isOpaque":true,"blurHash":"D47nu1xU%Lx^4n?dxtt7ofM{"},"uploadId":"3ct5wI5akdtTDeBzgjxMzDWJAYaAnmYK","mimeType":"image/png","sha1hash":"48b05b74a043a14725208c64dc5511c83f873960","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/48b05b74a043a14725208c64dc5511c83f873960-2048x738.png","path":"images/0vv8moc6/ajmc/48b05b74a043a14725208c64dc5511c83f873960-2048x738.png","_updatedAt":"2024-08-16T11:54:45Z","originalFilename":"flatiron canopy.png","_rev":"EDJmlW7GHoHEwq10zl3D3G","assetId":"48b05b74a043a14725208c64dc5511c83f873960","_id":"image-48b05b74a043a14725208c64dc5511c83f873960-2048x738-png"}},"url":"collaborative-innovation-flatiron-health-and-canopy-partner-to-streamline-continuous-care-for-oncology-practices","published":"2024-08-16T11:30:00.000Z","authorDetails":[{"lastName":"Kwiatkowsky","url":{"current":"lavi-kwiatkowsky","_type":"slug"},"profileImage":null,"biography":[{"children":[{"_type":"span","marks":[],"text":"Lavi Kwiatkowsky is the founder and CEO of Canopy.","_key":"33c855f42e2b0"}],"_type":"block","style":"normal","_key":"4839ffeb2829","markDefs":[]}],"showSocialShare":null,"displayName":"Lavi Kwiatkowsky","firstName":"lavi"},{"firstName":"Geoff","lastName":"Calkins","url":{"current":"geoff-calkins","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Geoff Calkins"}],"issueGroup":{"_ref":"8f469cb0-5c36-4eaf-ab0e-2a34a0c7bf53","_type":"reference"},"summary":null,"factCheckBy":[{"lastName":"Kwiatkowsky","url":{"current":"lavi-kwiatkowsky","_type":"slug"},"profileImage":null,"biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Lavi Kwiatkowsky is the founder and CEO of Canopy.","_key":"33c855f42e2b0"}],"_type":"block","style":"normal","_key":"4839ffeb2829"}],"showSocialShare":null,"displayName":"Lavi Kwiatkowsky","firstName":"lavi"},{"url":{"current":"geoff-calkins","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Geoff Calkins","firstName":"Geoff","lastName":"Calkins"}]},{"title":"Cardiometabolic Interventions Focus on Accessibility, Evidence-Based Medicine","summary":"At an Institute for Value-Based Medicine® (IVBM) event cohosted by The American Journal of Managed Care® and Sutter Health, experts illuminated the current state of cardiometabolic health care and offered a glimpse into the future.","thumbnail":{"_type":"mainImage","alt":"San Francisco's Golden Gate Bridge | Image Credit: © phitha - stock.adobe.com","asset":{"_updatedAt":"2024-06-07T15:30:01Z","metadata":{"_type":"sanity.imageMetadata","palette":{"muted":{"background":"#9c5c58","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.47},"lightVibrant":{"foreground":"#000","title":"#000","population":4.62,"background":"#fbe182","_type":"sanity.imagePaletteSwatch"},"darkVibrant":{"foreground":"#fff","title":"#fff","population":3.69,"background":"#6f2c2a","_type":"sanity.imagePaletteSwatch"},"lightMuted":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":8.5,"background":"#9099c0"},"vibrant":{"population":7.2,"background":"#f2a973","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"dominant":{"foreground":"#000","title":"#fff","population":8.5,"background":"#9099c0","_type":"sanity.imagePaletteSwatch"},"_type":"sanity.imagePalette","darkMuted":{"population":7.93,"background":"#2e3250","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,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","dimensions":{"width":1200,"aspectRatio":1.5,"height":800,"_type":"sanity.imageDimensions"},"exif":{"ISO":200,"SceneCaptureType":0,"LensSpecification":[70,300,4.5,5.6],"LightSource":14,"DigitalZoomRatio":1,"DateTimeOriginal":"2016-06-04T04:25:41.000Z","ShutterSpeedValue":-1.6780719083366258,"RecommendedExposureIndex":200,"FNumber":11,"ExposureBiasValue":0,"Sharpness":0,"FocalLengthIn35mmFormat":220,"ExposureMode":0,"LensModel":"FE 70-300mm F4.5-5.6 G OSS","FocalPlaneXResolution":2164.4328018223237,"FocalLength":220,"SensitivityType":2,"MaxApertureValue":4.970853658536585,"PixelYDimension":800,"ColorSpace":1,"FocalPlaneResolutionUnit":3,"PixelXDimension":1200,"ExposureProgram":3,"DateTimeDigitized":"2016-06-04T04:25:41.000Z","MeteringMode":5,"Saturation":0,"Contrast":0,"ExposureTime":3.2,"CustomRendered":0,"BrightnessValue":-0.44765625,"_type":"sanity.imageExifMetadata","WhiteBalance":1,"FocalPlaneYResolution":2164.4328018223237,"ApertureValue":6.9188632619439865},"isOpaque":true,"blurHash":"VuJ@2qs:WCjYbb}%soahbIjs-:R*WBoJW:I.W=WEoLj["},"uploadId":"O5nnIZFuz4knEBd9QmteN8nCCmR8xh2K","mimeType":"image/jpeg","sha1hash":"1f3095024fd984fa3a60b43c4cf33663635bcaf7","_rev":"SWZtARO2mf3vRstToueLld","assetId":"1f3095024fd984fa3a60b43c4cf33663635bcaf7","originalFilename":"San Francisco Golden Gate Bridge - phitha - stock.adobe.com.jpeg","path":"images/0vv8moc6/ajmc/1f3095024fd984fa3a60b43c4cf33663635bcaf7-1200x800.jpg","size":416089,"_createdAt":"2024-06-07T15:30:01Z","extension":"jpg","_type":"sanity.imageAsset","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/1f3095024fd984fa3a60b43c4cf33663635bcaf7-1200x800.jpg","_id":"image-1f3095024fd984fa3a60b43c4cf33663635bcaf7-1200x800-jpg"}},"published":"2024-06-14T13:00:00.000Z","authorDetails":[{"profileImage":{"_type":"mainImage","alt":"Giuliana Grossi","asset":{"_type":"reference","_ref":"image-5dc1da24786c43a7f87e4ea0a7ae3880e6cee39f-430x430-png"}},"biography":null,"showSocialShare":null,"displayName":"Giuliana Grossi","firstName":null,"lastName":null,"url":{"current":"giuliana-grossi","_type":"slug"}}],"_id":"1472df1f-ab77-4b68-8ced-12ff81256022","issueGroup":{"_ref":"c6747bef-322f-4aa5-bf20-1af9d678cde0","_type":"reference"},"url":"cardiometabolic-interventions-focus-on-accessibility-evidence-based-medicine","factCheckBy":[{"url":{"current":"giuliana-grossi","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Giuliana Grossi","asset":{"_ref":"image-5dc1da24786c43a7f87e4ea0a7ae3880e6cee39f-430x430-png","_type":"reference"}},"biography":null,"showSocialShare":null,"displayName":"Giuliana Grossi","firstName":null,"lastName":null}]},{"_id":"4d553701-915f-4873-8b9f-4f53893d6561","issueGroup":{"_ref":"c6747bef-322f-4aa5-bf20-1af9d678cde0","_type":"reference"},"thumbnail":{"_type":"mainImage","alt":"Cleveland Ohio | Image Credit: © Ai - stock.adobe.com.jpeg","asset":{"path":"images/0vv8moc6/ajmc/264df279db594adda69bc3737a08c6773f27a6ef-1200x800.jpg","assetId":"264df279db594adda69bc3737a08c6773f27a6ef","uploadId":"gcL2RcGUNOwVnVWGsh0ao9mQiEvDHrKK","_type":"sanity.imageAsset","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/264df279db594adda69bc3737a08c6773f27a6ef-1200x800.jpg","_updatedAt":"2024-06-07T15:42:37Z","mimeType":"image/jpeg","sha1hash":"264df279db594adda69bc3737a08c6773f27a6ef","originalFilename":"Cleveland Ohio - Ai - stock.adobe.com.jpeg","size":501001,"_createdAt":"2024-06-07T15:42:37Z","_id":"image-264df279db594adda69bc3737a08c6773f27a6ef-1200x800-jpg","extension":"jpg","metadata":{"palette":{"vibrant":{"foreground":"#fff","title":"#fff","population":5.13,"background":"#0d90d3","_type":"sanity.imagePaletteSwatch"},"dominant":{"foreground":"#fff","title":"#fff","population":6.22,"background":"#677397","_type":"sanity.imagePaletteSwatch"},"_type":"sanity.imagePalette","darkMuted":{"title":"#fff","population":2.79,"background":"#30384f","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"muted":{"background":"#677397","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":6.22},"lightVibrant":{"population":2.52,"background":"#efc989","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000"},"darkVibrant":{"population":0,"background":"#043484","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightMuted":{"foreground":"#000","title":"#fff","population":2.56,"background":"#8897be","_type":"sanity.imagePaletteSwatch"}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,/9j/2wBDAAYEBQYFBAYGBQYHBwYIChAKCgkJChQODwwQFxQYGBcUFhYaHSUfGhsjHBYWICwgIyYnKSopGR8tMC0oMCUoKSj/2wBDAQcHBwoIChMKChMoGhYaKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCj/wAARCAANABQDASIAAhEBAxEB/8QAGAAAAwEBAAAAAAAAAAAAAAAAAAUHBgj/xAAkEAABAwMEAQUAAAAAAAAAAAABAgMRAAQFBhIhUQcTFCIxYf/EABUBAQEAAAAAAAAAAAAAAAAAAAME/8QAHhEAAQQCAwEAAAAAAAAAAAAAAQACAxEEcRIUIUL/2gAMAwEAAhEDEQA/AKQ35C0ylMN3IeVMEbZ47pVmNaaVckKsw6jjnZXPGNWtF0n5khIkjundrql7HpdSm1t3gYI9QTB/KeFkmPTeRvaKUxzAuc0VpbXJZ3S3vF7Gdg6Ig0VHc1kXcnkXbt0BC3PsI4FFXdqceWohiYp+F//Z","dimensions":{"width":1200,"aspectRatio":1.5,"height":800,"_type":"sanity.imageDimensions"},"exif":{"FocalLength":18,"ExposureProgram":3,"_type":"sanity.imageExifMetadata","BrightnessValue":5.84,"FNumber":20,"DateTimeDigitized":"2016-07-24T00:00:00.000Z","Sharpness":0,"WhiteBalance":1,"LensSpecification":[18,55,2.8,4],"SubjectDistanceRange":0,"SensitivityType":1,"ColorSpace":1,"LensModel":"XF18-55mmF2.8-4 R LM OIS","FocalPlaneYResolution":2083.4231274638632,"Saturation":1,"SceneCaptureType":0,"ExposureBiasValue":0.33,"LightSource":11,"PixelXDimension":1200,"PixelYDimension":800,"SensingMethod":2,"DateTimeOriginal":"2016-07-24T18:28:07.000Z","ExposureMode":0,"CustomRendered":0,"ShutterSpeedValue":3.584962502403692,"ExposureTime":0.08333333333333333,"MeteringMode":5,"FocalPlaneResolutionUnit":3,"LensMake":"FUJIFILM","FocalPlaneXResolution":2083.4231274638632,"MaxApertureValue":2.9708536585365852,"LensSerialNumber":"48A03748","ISO":500,"ApertureValue":8.643856143856144,"FocalLengthIn35mmFormat":27},"isOpaque":true,"blurHash":"VwHx:8$xRit5WA_4$~jEaej[T1oMWEa}axENR-f6bIWC","_type":"sanity.imageMetadata"},"_rev":"FTf7O3KU2GxuMy4tElpSB4"}},"authorDetails":[{"displayName":"Laura Joszt, MA","firstName":"Laura","lastName":"Joszt","url":{"current":"laura-joszt","_type":"slug"},"profileImage":{"_type":"mainImage","alt":"Laura Joszt headshot","asset":{"_ref":"image-93ea362164e769dfd84dca31a8b2670a1dd9092b-512x512-jpg","_type":"reference"}},"biography":[{"markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"href":"https://twitter.com/joszt","_key":"c419f18a7ffe","_type":"link"}],"children":[{"_type":"span","marks":[],"text":"Laura is the vice president of content for The American Journal of Managed Care® (AJMC®) and all its brands, including The American Journal of Accountable Care®, Evidence-Based Oncology™, and The Center for Biosimilars®. She has been working on AJMC® since 2014 and has been with AJMC®’s parent company, MJH Life Sciences®, since 2011.","_key":"67a67d3764f00"}],"_type":"block","style":"normal","_key":"4a950aea97b3"},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"nofollow":true,"blank":true,"_type":"link","href":"https://twitter.com/joszt","_key":"c419f18a7ffe"}],"children":[{"_type":"span","marks":[],"text":"She has an MA in business and economic reporting from New York University. You can connect with Laura on ","_key":"48d199d8ecd5"},{"text":"LinkedIn","_key":"67a67d3764f01","_type":"span","marks":["f77b28536a8d"]},{"marks":[],"text":" or ","_key":"67a67d3764f02","_type":"span"},{"_type":"span","marks":["c419f18a7ffe"],"text":"Twitter","_key":"67a67d3764f03"},{"_type":"span","marks":[],"text":".","_key":"67a67d3764f04"}],"_type":"block","style":"normal","_key":"b28d8058b3d8"}],"showSocialShare":true}],"title":"Experts Highlight How GLP-1s Have Revolutionized Management of T2D and Obesity ","summary":"The number of Americans with type 2 diabetes and/or obesity is rising, and the entry of therapies such as glucagon-like peptide-1 (GLP-1) receptor agonists has been revolutionary.","url":"experts-highlight-how-glp-1s-have-revolutionized-management-of-t2d-and-obesity","published":"2024-06-13T19:00:00.000Z","factCheckBy":[{"lastName":"Joszt","url":{"current":"laura-joszt","_type":"slug"},"profileImage":{"alt":"Laura Joszt headshot","asset":{"_ref":"image-93ea362164e769dfd84dca31a8b2670a1dd9092b-512x512-jpg","_type":"reference"},"_type":"mainImage"},"biography":[{"children":[{"_type":"span","marks":[],"text":"Laura is the vice president of content for The American Journal of Managed Care® (AJMC®) and all its brands, including The American Journal of Accountable Care®, Evidence-Based Oncology™, and The Center for Biosimilars®. She has been working on AJMC® since 2014 and has been with AJMC®’s parent company, MJH Life Sciences®, since 2011.","_key":"67a67d3764f00"}],"_type":"block","style":"normal","_key":"4a950aea97b3","markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"_type":"link","href":"https://twitter.com/joszt","_key":"c419f18a7ffe"}]},{"children":[{"text":"She has an MA in business and economic reporting from New York University. You can connect with Laura on ","_key":"48d199d8ecd5","_type":"span","marks":[]},{"_type":"span","marks":["f77b28536a8d"],"text":"LinkedIn","_key":"67a67d3764f01"},{"_type":"span","marks":[],"text":" or ","_key":"67a67d3764f02"},{"_type":"span","marks":["c419f18a7ffe"],"text":"Twitter","_key":"67a67d3764f03"},{"_type":"span","marks":[],"text":".","_key":"67a67d3764f04"}],"_type":"block","style":"normal","_key":"b28d8058b3d8","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"href":"https://twitter.com/joszt","_key":"c419f18a7ffe","nofollow":true,"blank":true,"_type":"link"}]}],"showSocialShare":true,"displayName":"Laura Joszt, MA","firstName":"Laura"}]},{"title":"Reducing Delays in Breast Cancer Care Using an Innovative Digital Health Platform","summary":"The use of a novel digital health platform achieved a 55% reduction in time to treatment among women with a new diagnosis of breast cancer.","published":"2024-06-13T13:00:00.000Z","authorDetails":[{"biography":null,"showSocialShare":null,"displayName":"Dennis R. Holmes, MD","firstName":"Dennis","lastName":"Holmes","url":{"current":"dennis-r-holmes-md","_type":"slug"},"profileImage":null},{"biography":null,"showSocialShare":null,"displayName":"Steven D. Evans, MD","firstName":"Steven","lastName":"Evans","url":{"current":"steven-d-evans-md","_type":"slug"},"profileImage":null},{"displayName":"Warren Fisher, DO","firstName":"Warren","lastName":"Fisher","url":{"_type":"slug","current":"warren-fisher-do"},"profileImage":null,"biography":null,"showSocialShare":null},{"biography":null,"showSocialShare":null,"displayName":"Darren Wheeler, MD","firstName":"Darren","lastName":"Wheeler","url":{"current":"darren-wheeler-md","_type":"slug"},"profileImage":null},{"displayName":"Riya Pulicharam, MD, CPI","firstName":"Riya","lastName":"Pulicharam","url":{"_type":"slug","current":"riya-pulicharam-md-cpi"},"profileImage":null,"biography":null,"showSocialShare":null}],"_id":"e881417a-9e64-48ca-9b72-7daafa2dd9c4","issueGroup":{"_ref":"c6747bef-322f-4aa5-bf20-1af9d678cde0","_type":"reference"},"factCheckBy":[{"url":{"current":"dennis-r-holmes-md","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Dennis R. Holmes, MD","firstName":"Dennis","lastName":"Holmes"},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Steven D. Evans, MD","firstName":"Steven","lastName":"Evans","url":{"current":"steven-d-evans-md","_type":"slug"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Warren Fisher, DO","firstName":"Warren","lastName":"Fisher","url":{"current":"warren-fisher-do","_type":"slug"}},{"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Darren Wheeler, MD","firstName":"Darren","lastName":"Wheeler","url":{"current":"darren-wheeler-md","_type":"slug"}},{"firstName":"Riya","lastName":"Pulicharam","url":{"current":"riya-pulicharam-md-cpi","_type":"slug"},"profileImage":null,"biography":null,"showSocialShare":null,"displayName":"Riya Pulicharam, MD, CPI"}],"thumbnail":{"_type":"mainImage","alt":"Medical technology and digital health network concept | Image Credit: © ipopba - stock.adobe.com","asset":{"_createdAt":"2023-09-25T20:33:46Z","originalFilename":"Medicine doctor hold icon health and electronic medical record on interface. Digital healthcare and network connection on hologram virtual screen, insurance. medical technology and network concept - ipopba - stock.adobe.com.jpeg","mimeType":"image/jpeg","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/1e602bba35858bd62230432132517d1d42061e3d-1280x800.jpg","sha1hash":"1e602bba35858bd62230432132517d1d42061e3d","path":"images/0vv8moc6/ajmc/1e602bba35858bd62230432132517d1d42061e3d-1280x800.jpg","assetId":"1e602bba35858bd62230432132517d1d42061e3d","extension":"jpg","metadata":{"lqip":"data:image/jpeg;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":1280,"aspectRatio":1.6,"height":800},"isOpaque":true,"blurHash":"VKJ01o~pIBTJo#K6MxxuRjs:R6xuNGxuRORi-;IUSexb","_type":"sanity.imageMetadata","palette":{"muted":{"foreground":"#fff","title":"#fff","population":7.54,"background":"#629eb9","_type":"sanity.imagePaletteSwatch"},"lightVibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#000","population":3.38,"background":"#badff5"},"darkVibrant":{"background":"#205a7b","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":8.47},"lightMuted":{"background":"#a4c2d3","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":4.58},"vibrant":{"background":"#2bc4d6","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":1.22},"dominant":{"background":"#205a7b","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":8.47},"_type":"sanity.imagePalette","darkMuted":{"foreground":"#fff","title":"#fff","population":0.14,"background":"#655176","_type":"sanity.imagePaletteSwatch"}},"hasAlpha":false},"_type":"sanity.imageAsset","size":323017,"_id":"image-1e602bba35858bd62230432132517d1d42061e3d-1280x800-jpg","_updatedAt":"2023-09-25T20:33:46Z","uploadId":"hTRTLrPbL2uAPSQkjvmAG41W4tGru8UX","_rev":"pEhoUqandJkxjPidorVwRV"}},"url":"reducing-delays-in-breast-cancer-care-using-an-innovative-digital-health-platform"}],"isLiveSite":true,"host":"www.ajmc.com","settings":{"title":"AJMC","networkID":"4688","adUnit":"ajmc.com","liveDomain":"www.ajmc.com","publicationName":"AJMC","logo":"/ajmc_logo_inverted.png","white_logo":"/ajmc_logo_inverted.png","logoHeight":"50px","enableEdgeCache":true,"sMaxAge":300,"staleWhileRevalidate":359,"clinicalTopicTopLatestNews":true,"megaMenuTaxName":"topic","megaMenuChildren":true,"sharingImageUrl":"https://s3.amazonaws.com/mjhlifesciences.com/sitelogos/AJMC_1200x637.png","twitterHandle":"@AJMC_Journal","publicationMapping":"publications","useNewSubNavMegaMenu":true,"redesignDetail":true,"redesignSAP":true,"useNewFooter":true,"newFooterLogos":[{"img":"/CHA_Logo.png","alt":"CH Logo","mobileWidth":"158px","mobileHeight":"42px","link":"/topic/center-on-health-equity-and-access","target":"_self"},{"img":"/CB.png","alt":"Center for Biosimilars Logo","mobileWidth":"170px","mobileHeight":"42px","link":"https://www.centerforbiosimilars.com/","target":"_blank"}],"useV3Components":true,"useAuthorRedesign":true,"navigationOptions":{"version":"2","variant":"4","customSpecialtyText":"Speciality Area"},"gateEnabled":"modal"},"homepage_creative_layout":{"creativeLayout":null}},"targeting":{"content_placement":["compendium/gene-therapy","topic/clinical","news"],"document_url":["new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma"],"document_group":[],"content_group":[],"rootDocumentGroup":[],"issue_url":[],"publication_url":[],"tags":["haploidentical HSCT ","CAR T-cell therapy ","CD7-Positive Leukemia/Lymphoma"],"hostname":"www.ajmc.com"},"statusCode":200,"data":{"page":{"intro":null,"contentCategories":null,"archived":false,"labelRequired":false,"gateCode":null,"featureContent":null,"pageSliders":null,"content":null,"cmeConfig":null,"externalLinks":null,"searchConfig":{"baseUrl":"/view/"},"styling":{"imageControl":{"_type":"imageControl","showImage":true},"divider":{"_type":"divider","dividerSize":1},"border":{"borderRadius":{"bottomRight":"rounded-none","topLeft":"rounded-none","topRight":"rounded-none","bottomLeft":"rounded-none"},"_type":"border","borderSize":0,"borderType":"lines"},"contentControl":{"showSummary":true,"_type":"contentControl","showPublished":true,"readMore":true,"showAuthor":true}},"useV3":null,"title":"View","creativeLayout":null,"franchise":null,"fixIdentifier":null,"isDsoGated":null,"orderDesc":null,"creativeLayoutDetail":null,"url":{"current":"/view","_type":"slug"},"docGroup":null,"taxonomy":null,"filterRequired":false,"disableEpisode":null,"pageType":"Article Detail","contentCategory":null,"linkedPage":null,"filters":null,"articleDetailConfig":{"disqusShortName":"www-ajmc-com","downloadCitation":true,"shareOptions":{"twitterHandle":"AJMC","siteName":"ajmc","hideFacebook":false,"SocialIconSize":32,"twitterSiteName":"@AJMC_Journal","hidePinterest":false,"shareSubject":"Check out this article!","thumbnail":{"_type":"mainImage","alt":"3D rendering of a CAR T cell | Image Credit: Naeblys-stock.adobe.com","asset":{"_ref":"image-04663c88d2d04992175ced53fda8bb885d2d2ee8-1200x724-jpg","_type":"reference"}}},"brightcovePlayerID":"pbDmfQhRw","drupalleadBaseURL":"https://drupalleads.mjh.group/injectablewebform/output/","issueMapping":"/publications","enableSegmentRecommend":true,"brightcoveAccountID":"10203567001"},"relatedMegaMenu":null,"excludeFromSitemap":false,"identifier":null,"parent":null,"creativeLayoutLatestNews":null,"hasSubCategory":false,"label":null,"theme":"default","pages":null,"videoPlayerConfig":null},"pageData":{"article":{"_rev":"57p6Fq1KahgNk455bmuTuK","contentCategory":{"_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","name":"Articles"},"_id":"9109232d-ed88-49c1-b50e-7bfa373ea3e2","url":{"current":"new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma","_type":"slug"},"ExcludeFromPubMedXML":false,"issueGroup":null,"articleType":"News","is_visible":true,"thumbnail":{"_type":"mainImage","alt":"3D rendering of a CAR T cell | Image Credit: Naeblys-stock.adobe.com","asset":{"_ref":"image-04663c88d2d04992175ced53fda8bb885d2d2ee8-1200x724-jpg","_type":"reference"}},"factCheckAuthorMapping":null,"summary":"This study introduces a novel \"all-in-one\" strategy combining CD7 chimeric antigen receptor T-cell therapy with haploidentical hematopoietic stem-cell transplantation, showing significant potential to improve survival and reduce toxicities in patients with relapsed or refractory CD7-positive hematologic cancers.\n","title":"New Strategy Shows Promise for CD7-Positive Leukemia/Lymphoma","_updatedAt":"2024-05-09T14:16:32Z","_type":"article","documentGroupMapping":null,"filter":null,"pdfUrl":null,"contentGroup":null,"body":[{"_key":"dfc646902114","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.nejm.org/doi/full/10.1056/NEJMoa2313812","_key":"5b743219b582"},{"href":"https://www.ajmc.com/compendium/gene-therapy","_key":"755a5144f88d","nofollow":false,"blank":true,"_type":"link"}],"children":[{"text":"In a recent study published in ","_key":"555c7880a3940","_type":"span","marks":[]},{"_type":"span","marks":["em","5b743219b582"],"text":"The New England Journal of Medicine","_key":"6a47dbea31ab"},{"_type":"span","marks":[],"text":", researchers introduced a novel \"all-in-one\" strategy that combines CD7 ","_key":"588064e8acb0"},{"_type":"span","marks":["755a5144f88d"],"text":"chimeric antigen receptor (CAR) T-cell therapy","_key":"7a832a7f5d48"},{"_type":"span","marks":[],"text":" with haploidentical hematopoietic stem-cell transplantation (HSCT) to treat patients with relapsed or refractory CD7-positive leukemia and lymphoma.","_key":"a1e1ff068e2f"},{"marks":["superscript"],"text":"1","_key":"8c8d7a687e3a","_type":"span"}],"_type":"block","style":"normal"},{"style":"normal","_key":"dc492489cbc1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bb3c532460b50"}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null},{"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Relapsed or refractory hematologic cancers typically have a dire prognosis, with traditional treatments often leading to a 5-year overall survival of less than 20%. Toxicities from pretransplant conditioning and graft-vs-host disease (GVHD) prophylaxis have limited the integration of CAR T-cell therapy as a bridge to allogeneic HSCT.","_key":"6ecd09ab59df0"},{"text":"2","_key":"20abefddeaec","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" This all-in-one strategy avoids traditional pharmacologic myeloablation and GVHD prophylaxis and has shown promising results for patients with limited therapeutic options.","_key":"ba5bd1d2b38a"}],"_type":"block","style":"normal","_key":"daeade57d825","upload_doc":null},{"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_key":"3eb691740bd70","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"30b2ef8a0dab","upload_doc":null},{"style":"normal","_key":"f9b7a2563771","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"text":"The researchers noted, \"Our findings suggest that sequential CD7 CAR T-cell therapy and haploidentical HSCT is safe and effective, with remission and serious but reversible adverse events. This strategy offers a feasible approach for patients with CD7-positive tumors who are ineligible for conventional allogeneic HSCT.\"","_key":"9939a4fc4fd60","_type":"span","marks":[]}],"_type":"block"},{"upload_doc":null,"uploadAudio":null,"medias":null,"children":[{"_type":"span","marks":[],"text":"","_key":"9fd89598230d0"}],"_type":"block","style":"normal","_key":"89a223917898","markDefs":[]},{"upload_doc":null,"_type":"figure","alt":"Blood analysis | Image Credit: Parilov - stock.adobe.com","imgcaption":[{"style":"normal","_key":"4fce69d32582","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Investigators have introduced a treatment combination of combines CD7 T-cell therapy and haploidentical HSCT to treat patients with relapsed or refractory CD7-positive leukemia and lymphoma | Image Credit: Parilov - stock.adobe.com","_key":"ac1ce41c06900"}],"_type":"block"}],"_key":"d89ce6e2c2ef","alignment":"left","asset":{"_ref":"image-bf0fd40c2eaca790ecb7789da62cf293a90a2b79-1200x724-jpg","_type":"reference"},"widthP":30,"uploadAudio":null,"medias":null},{"style":"normal","_key":"8076273fdd92","markDefs":[],"upload_doc":null,"uploadAudio":null,"medias":null,"children":[{"marks":[],"text":"The study, completed at the Bone Marrow Transplantation Center at Zhejiang University School of Medicine, involved 10 patients who underwent sequential therapy, including 7 with acute myeloid leukemia, 2 with T-cell acute lymphoblastic leukemia, and 1 with T-cell lymphoblastic lymphoma (grade IVa). These patients had previously shown poor responses to conventional treatments, completing a median of 9.5 (range, 4-15) therapy courses.","_key":"313f503f05a40","_type":"span"}],"_type":"block"},{"medias":null,"_key":"dcaa0161448a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c55bf9185b070"}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null},{"medias":null,"style":"normal","_key":"e91aeeddfe4a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Undergoing sequential therapy","_key":"21766ca24bab0"},{"_type":"span","marks":["strong"],"text":",","_key":"21766ca24bab2"},{"_type":"span","marks":[],"text":" starting with CD7 CAR T-cell therapy followed by haploidentical HSCT","_key":"21766ca24bab3"},{"text":", ","_key":"21766ca24bab4","_type":"span","marks":["strong"]},{"text":"all patients achieved complete remission, albeit with incomplete hematologic recovery. At 1 year post treatment, the overall survival rate was 68% (95% CI, 43%-100%), and the disease-free survival rate was 54% (95% CI, 29%-100%). The absence of pharmacologic myeloablation and GVHD prophylaxis drugs, relying instead on the immunosuppressive effects of the CAR T cells, presents a less toxic and potentially more effective treatment method.","_key":"a7062faffa36","_type":"span","marks":[]}],"_type":"block","upload_doc":null,"uploadAudio":null},{"style":"normal","_key":"6601a30dc8b0","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"text":"","_key":"4ac35b61498a0","_type":"span","marks":[]}],"_type":"block"},{"upload_doc":null,"uploadAudio":null,"medias":null,"style":"normal","_key":"47b9fa886ecc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Serious but reversible adverse events were reported, including grade 4 pancytopenia observed in all patients following CAR T-cell therapy, which was expected due to the therapy's mechanism. Following HSCT, 1 patient died from septic shock and another from encephalitis, highlighting the treatment's significant risks. Additionally, 3 patients developed grade 2 HSCT-associated acute GVHD. The median follow-up was 15.1 (range, 3.1-24.0) months after CAR T-cell therapy. Six patients remained in minimal residual disease–negative complete remission during the follow-up period.","_key":"e58830638caa0"}],"_type":"block"},{"markDefs":[],"upload_doc":null,"uploadAudio":null,"medias":null,"children":[{"_type":"span","marks":[],"text":"","_key":"89e399a39dde0"}],"_type":"block","style":"normal","_key":"6fa863c0881d"},{"upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"marks":[],"text":"The researchers acknowledged the limitations of their study, including its small sample size and the exploratory nature of the treatment.","_key":"6f03af5d44810","_type":"span"}],"_type":"block","style":"normal","_key":"6103e94a30fc"},{"style":"normal","_key":"b8f2356636e0","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b9d3e06580740"}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null},{"medias":null,"_type":"block","style":"normal","_key":"bf8dc57251fc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"They noted that \"because we were evaluating a new therapeutic strategy, the findings of this study still need to be extended and confirmed in a larger and more homogeneous cohort of patients.\"","_key":"3b8bb95345160"}],"upload_doc":null,"uploadAudio":null},{"upload_doc":null,"uploadAudio":null,"medias":null,"_key":"00c7627bf2ce","markDefs":[],"children":[{"marks":[],"text":"","_key":"dd2809a57b000","_type":"span"}],"_type":"block","style":"normal"},{"upload_doc":null,"uploadAudio":null,"medias":null,"_key":"f2ee9d6cedfd","markDefs":[],"children":[{"_key":"35a5cef6ebb60","_type":"span","marks":[],"text":"Although the results of the study are promising, the authors acknowledge the need for larger, more definitive trials to confirm these results and potentially expand the therapy's application."}],"_type":"block","style":"normal"},{"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6d95b7e14f590"}],"_type":"block","style":"normal","_key":"ad424ce576a0","upload_doc":null,"uploadAudio":null},{"_key":"87fd3d76e277","markDefs":[],"upload_doc":null,"uploadAudio":null,"medias":null,"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"f3b6fe9a29450"}],"_type":"block","style":"normal"},{"uploadAudio":null,"medias":null,"children":[{"_type":"span","marks":[],"text":"1. Hu Y, Zhang M, Yang T, et al. Sequential CD7 CAR T-cell therapy and allogeneic HSCT without GVHD prophylaxis. ","_key":"2eae4bd7aaeb0"},{"_type":"span","marks":["em"],"text":"N Engl J Med","_key":"2eae4bd7aaeb1"},{"marks":[],"text":". 2024;390(16):1467-1480. doi:10.1056/NEJMoa2313812","_key":"2eae4bd7aaeb2","_type":"span"}],"_type":"block","style":"normal","_key":"4df79c6e1207","markDefs":[],"upload_doc":null},{"children":[{"marks":[],"text":"2. Ellard R, Kenyon M, Hutt D, et al. The EBMT immune effector cell nursing guidelines on CAR-T therapy: a framework for patient care and managing common toxicities. ","_key":"a0240848e72c0","_type":"span"},{"marks":["em"],"text":"Clin Hematol Int","_key":"a0240848e72c1","_type":"span"},{"text":". 2022;4(3):75-88. doi:10.1007/s44228-022-00004-8","_key":"a0240848e72c2","_type":"span","marks":[]}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null,"style":"normal","_key":"354dc8c762db","markDefs":[]}],"_createdAt":"2024-05-09T14:16:32Z","seoTag":["haploidentical HSCT ","CAR T-cell therapy ","CD7-Positive Leukemia/Lymphoma"],"published":"2024-05-09T14:16:29.396Z","authorMapping":[{"_id":"9b4faadd-6cd1-4c3e-8bc2-48c752241cea","biography":[{"children":[{"_type":"span","marks":[],"text":"Kimberly Rath, PharmD, is a freelance health writer who previously worked as a clinical pharmacist with Elevance Health for a decade. She has also worked for Amerigroup and Sentara Group.","_key":"19953fe47e02"}],"_type":"block","style":"normal","_key":"7a10018db04a","markDefs":[]}],"_updatedAt":"2024-04-12T12:56:17Z","url":{"current":"kimberly-rath-pharmd","_type":"slug"},"displayName":"Kimberly Rath, PharmD","_createdAt":"2024-04-12T12:56:17Z","_rev":"qNe2e9NrqyCsTecezTdgy6","_type":"author"}],"taxonomyMapping":[{"video":{"isTaxVideo":false},"identifier":"gene-therapy","_updatedAt":"2023-08-21T19:12:56Z","pixelTrackingCode":null,"_type":"taxonomy","parent":{"isMainTopic":true,"_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","parent":null,"name":"Compendium","_updatedAt":"2024-04-09T09:14:18Z","identifier":"compendium","_createdAt":"2020-03-30T18:16:46Z","_rev":"oruil6rlosjyltJbhrNMGF","_type":"taxonomy"},"_createdAt":"2023-08-21T19:12:56Z","_rev":"oDd7mxRXduX0QlayjeWnR7","name":"Gene Therapy","usedForRecommendations":false,"_id":"a2b81a45-b589-4252-b45d-cf65773d1186"},{"name":"Clinical","_id":"topic_clinical","_updatedAt":"2022-02-18T12:13:55Z","pixelTrackingCode":null,"_rev":"HexDiduX8d6Nqnq1ECriVF","_type":"taxonomy","summary":[{"markDefs":[],"children":[{"marks":[],"text":"The ","_key":"e80c79954e08","_type":"span"},{"text":"AJMC","_key":"a8e0f75c5d05","_type":"span","marks":["em"]},{"_type":"span","marks":["superscript"],"text":"®","_key":"f7d4dddf7edd"},{"_type":"span","marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a"},{"_key":"cc409f2da7da","_type":"span","marks":["em"],"text":"The American Journal of Managed Care"},{"marks":["superscript"],"text":"®","_key":"2babb3e59bb3","_type":"span"},{"_key":"d86a5bb12052","_type":"span","marks":[],"text":" and "},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"_key":"b59bef533cdf","_type":"span","marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology."}],"_type":"block","style":"normal","_key":"dd8ad578cd0b"}],"identifier":"clinical","_createdAt":"2020-05-04T23:46:13Z","parent":{"_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","name":"Topic","identifier":"topic","isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","_rev":"SpZIJtjiAn4ebHE4u6sWYc","parent":null}},{"_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z","parent":null,"pixelTrackingCode":null,"_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","name":"News","identifier":"news","_createdAt":"2020-03-30T18:05:45Z"}],"documentGroup":null,"issueSection":null,"disableAds":false,"disableRelatedContent":false,"relatedArticles":[{"_rev":"fWx7QmWGimMXMJ6HKPSgvs","ExcludeFromPubMedXML":false,"drugMentions":"{\n \"drug_mentions\": [\"Pirfenidone\", \"nintedanib\"]\n}","published":"2024-11-27T17:30:00.000Z","_id":"c1bb1c8c-298c-4573-a961-9068b91850ac","taxonomyMapping":[{"_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","pixelTrackingCode":null,"parent":null,"identifier":"news","_createdAt":"2020-03-30T18:05:45Z","_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","name":"News","_updatedAt":"2022-01-19T10:20:16Z"},{"identifier":"clinical","_type":"taxonomy","_rev":"HexDiduX8d6Nqnq1ECriVF","summary":[{"_type":"block","style":"normal","_key":"dd8ad578cd0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e80c79954e08"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"a8e0f75c5d05"},{"marks":["superscript"],"text":"®","_key":"f7d4dddf7edd","_type":"span"},{"marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"cc409f2da7da"},{"marks":["superscript"],"text":"®","_key":"2babb3e59bb3","_type":"span"},{"marks":[],"text":" and ","_key":"d86a5bb12052","_type":"span"},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"_type":"span","marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.","_key":"b59bef533cdf"}]}],"_createdAt":"2020-05-04T23:46:13Z","_updatedAt":"2022-02-18T12:13:55Z","pixelTrackingCode":null,"parent":{"_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","parent":null,"_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","identifier":"topic","isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","_type":"taxonomy"},"name":"Clinical","_id":"topic_clinical"},{"_type":"taxonomy","video":{"isTaxVideo":false},"_updatedAt":"2024-02-20T21:35:20Z","name":"Idiopathic Pulmonary Fibrosis","pixelTrackingCode":null,"_createdAt":"2024-02-20T21:26:26Z","usedForRecommendations":false,"_id":"73b8bfdf-d1e7-4a22-8d5f-6505a95cf504","identifier":"ipf","parent":{"name":"Compendium","identifier":"compendium","isMainTopic":true,"_rev":"oruil6rlosjyltJbhrNMGF","_type":"taxonomy","_createdAt":"2020-03-30T18:16:46Z","parent":null,"_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_updatedAt":"2024-04-09T09:14:18Z"},"_rev":"UC0fd9ecTWj4RIkTKuZkl5"}],"gptTakeaways":"• Antifibrotic treatment rates for IPF differ significantly between referral hospitals and general hospitals or clinics, with higher rates in referral hospitals.\n\n• Many patients with mild IPF remain untreated, often due to mild symptoms, imaging findings, or oxygenation levels, regardless of the facility type.\n\n• Symptom severity influences therapeutic intervention decisions in general hospitals but not in referral hospitals, where treatment rates are not associated with PS, mMRC score, or LTOT use.\n\n• The study's rural setting and focus on a Japanese population limit its generalizability, highlighting the need for further research in diverse settings.","title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","articleType":"News","factCheckAuthors":null,"summary":"A study in Japan found that antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics.","_updatedAt":"2024-11-27T15:19:33Z","authorMapping":[{"lastName":"McCormick","_createdAt":"2023-06-21T17:59:19Z","_rev":"m9zO7fOEUWAduYt5irO78Q","url":{"current":"brooke-mccormick","_type":"slug"},"firstName":"Brooke","_type":"author","_id":"00af9d05-a2c4-4451-a6d1-0e28b08cbb65","biography":[{"markDefs":[],"children":[{"marks":[],"text":"Brooke is an assistant editor for ","_key":"8d68730a8da0","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"730c46c984c9"},{"_type":"span","marks":[],"text":"® (","_key":"0b218fbaa571"},{"_key":"b1b5b3d9cff0","_type":"span","marks":["em"],"text":"AJMC"},{"_type":"span","marks":[],"text":"®). She joined ","_key":"7de919198f04"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"f31a60d737e2"},{"_type":"span","marks":[],"text":" in 2023, where she produces written content covering multiple disease states.","_key":"df11193684f8"}],"_type":"block","style":"normal","_key":"936ecf4b7f0c"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"5731fbb8e0ae","_type":"span"}],"_type":"block","style":"normal","_key":"9af540ce04de"},{"style":"normal","_key":"98aee68dab9d","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/brooke-mccormick-1a254b1b6/","_key":"80a1c1a9d7cd"}],"children":[{"marks":[],"text":"She has a BA in journalism from Seton Hall University. You can connect with Brooke on ","_key":"bb68b5e8ee83","_type":"span"},{"_type":"span","marks":["80a1c1a9d7cd"],"text":"LinkedIn","_key":"4bb222fe2840"},{"_type":"span","marks":[],"text":".","_key":"c87621477700"}],"_type":"block"}],"profileImage":{"_type":"mainImage","alt":"Brooke McCormick","asset":{"_ref":"image-1fe4e81696463cdd9c1d6b62a2e47c2228d7df99-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:29:20Z","displayName":"Brooke McCormick"}],"documentGroup":null,"body":[{"_key":"ff6ecb5b1447","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.sciencedirect.com/science/article/pii/S2212534524001473?via%3Dihub","_key":"e0271b7639c1"},{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/ipf","_key":"3fff99c17aa5"}],"children":[{"_type":"span","marks":[],"text":"Antifibrotic treatment interventions for patients with ","_key":"2c6ea1f7f93f0"},{"_type":"span","marks":["3fff99c17aa5"],"text":"idiopathic pulmonary fibrosis (IPF)","_key":"0e03f54bc272"},{"_type":"span","marks":[],"text":" differed by facility among those with good performance status (PS), according to a study published in ","_key":"12a5c7146d00"},{"_key":"2c6ea1f7f93f1","_type":"span","marks":["e0271b7639c1","em"],"text":"Respiratory Investigation"},{"_key":"2c6ea1f7f93f2","_type":"span","marks":["em"],"text":"."},{"_type":"span","marks":["superscript"],"text":"1","_key":"f6e7d7d854a3"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"a8bb5d50826a0"}],"_type":"block","style":"normal","_key":"74b00f0b9a91","markDefs":[]},{"_type":"block","style":"normal","_key":"0f32077b8479","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.atsjournals.org/doi/10.1164/rccm.201506-1063ST?url_ver=Z39.88-2003\u0026rfr_id=ori:rid:crossref.org\u0026rfr_dat=cr_pub%20%200pubmed","_key":"e101f6e6119b"}],"children":[{"_type":"span","marks":[],"text":"Pirfenidone and nintedanib, 2 antifibrotic agents, were conditionally ","_key":"f9893d4efac20"},{"text":"recommended","_key":"9efc2755f6de","_type":"span","marks":["e101f6e6119b"]},{"text":" for patients with IPF in 2015 clinical practice guidelines.","_key":"5c5665a87240","_type":"span","marks":[]},{"_type":"span","marks":["superscript"],"text":"2","_key":"9f30dbcdad11"},{"_type":"span","marks":[],"text":" Phase 3 trials showed that pirfenidone reduced disease progression in patients with IPF compared with placebo.","_key":"2b460d32f94f"},{"_type":"span","marks":["superscript"],"text":"1","_key":"c83540f59a89"},{"_type":"span","marks":[],"text":" Similarly, other phase 3 trials demonstrated that nintedanib slows the decline in forced vital capacity (FVC) and decreases the risk of acute exacerbation in patients with IPF.","_key":"d79f0f4ba038"}]},{"_type":"block","style":"normal","_key":"556622a68323","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c647fe9caecb0"}]},{"children":[{"_type":"span","marks":[],"text":"Despite these benefits, an online survey of respiratory physicians across Europe found that 54% of those with IPF were not receiving antifibrotic therapy. The researchers noted that many untreated patients had mild IPF, indicating a lack of proactive treatment.","_key":"1786ff5389d00"}],"_type":"block","style":"normal","_key":"185ec7c45c7d","markDefs":[]},{"_key":"bd544b033879","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ba73852589c10"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"Conversely, some cases present challenges for initiating antifibrotic therapy, and poor PS can hinder treatment continuation; starting therapy in patients with preserved PS is preferable. Building on past research, the researchers surveyed general practitioners and respiratory physicians in Japan to determine the proportion of untreated patients with IPF and factors associated with nonintervention.","_key":"5579653999780","_type":"span"}],"_type":"block","style":"normal","_key":"66c63c57ca1a"},{"widthP":40,"imgcaption":[{"_key":"308532b7e3b2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics. | Image Credit: Spiroview Inc. - stock.adobe.com","_key":"2b83b0b08ece"}],"_type":"block","style":"normal"}],"asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"},"alignment":"right","_type":"figure","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","disableTextWrap":false,"disableLightBox":true,"_key":"2939b480fd65"},{"_type":"block","style":"normal","_key":"218de00e81b4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study was conducted at 23 medical facilities (9 clinics, 12 general hospitals, 1 university hospital, and 1 specialized respiratory hospital) in Yamaguchi, Japan, from December 2019 to October 2020. The researchers included patients diagnosed with IPF at the study facility.","_key":"92476cdfcdbf0"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"5c74ca26fc0a0","_type":"span"}],"_type":"block","style":"normal","_key":"e0ebc73c01cc"},{"children":[{"_type":"span","marks":[],"text":"Both physicians and patients conducted the surveys. Patients completed a 3-item questionnaire on PS, cough symptom severity, and the modified Medical Research Council (mMRC) scale. In contrast, physicians recorded patients' demographic data, clinical characteristics, and IPF diagnoses. They also recorded clinical examination data, treatment details, when treatment started, and why; for those who did not receive treatment, the physicians recorded the reasons why.","_key":"32a68fa996790"}],"_type":"block","style":"normal","_key":"7e25fab5b342","markDefs":[]},{"children":[{"text":"","_key":"8a631a22d4fb0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"5df46ffb0cc2","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Physicians in the specialized respiratory and university hospitals also asked about the time from diagnosis at other facilities to referral, pulmonary function test (PFT) results, and Krebs von den Lungen 6 (KL-6) and surfactant protein D (Sp-D) values at the initial visit. ","_key":"777ac23244e30"}],"_type":"block","style":"normal","_key":"24cdddf66e01"},{"_key":"8d63c4c5ab36","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7c39b5f03be4"}],"_type":"block","style":"normal"},{"_key":"ed023c3455f7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers performed a principal component analysis (PCA) using 15 clinical variables, including age, sex, medical facility, body mass index (BMI), specialized tests, and symptom severity. In the PCA plots, the researchers evaluated the distribution of clinical variables vs antifibrotic treatment.","_key":"2ecfffb092c6"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"1b5aff0d650c","markDefs":[],"children":[{"text":"","_key":"e78245645f0a0","_type":"span","marks":[]}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers enrolled 518 patients with interstitial lung disease (ILD) in the study, 207 of whom were diagnosed with IPF. Among these 207 patients, 168 had a good PS, or a PS of 2 or less, which could indicate their treatment eligibility. Their mean (SD) age was 76.5 (8.2), and most (72.6%) were male. Also, 125 (74%) received treatment at a general hospital, 29 (17%) at either a specialized respiratory or a university hospital, and 14 (8%) at a clinic.","_key":"72be55df72210"}],"_type":"block","style":"normal","_key":"5f9e9f8aea0d"},{"_type":"block","style":"normal","_key":"8a0422349fc3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d2dda4277fa10"}]},{"children":[{"_type":"span","marks":[],"text":"Of those with IPF, 39 (22.6%) received an antifibrotic drug. The PCA determined that the rate of antifibrotic treatment was significantly higher in referral hospitals than in clinics or general hospitals. Based on physicians’ questionnaires, most did not prescribe antifibrotic drugs due to mild symptoms, imaging findings, or oxygenation, with no differences between facilities. ","_key":"f402874016ac0"}],"_type":"block","style":"normal","_key":"857ca7efc518","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c5ae02e7402f"}],"_type":"block","style":"normal","_key":"9a3542063244"},{"markDefs":[],"children":[{"marks":[],"text":"However, for those who received antifibrotic drugs, the time from diagnosis to treatment in referral hospitals (16 cases) and general hospitals (20 cases) was a mean (SD) of 24.5 (35.7) and 35.5 (40.0) months, respectively; there were no significant differences.","_key":"c1b9ce7e0a5d","_type":"span"}],"_type":"block","style":"normal","_key":"558459c819ac"},{"style":"normal","_key":"405c9cc5899e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"31a7e09702620"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers found that treatment rates were significantly higher among patients with poor PS, higher mMRC scores, and long-term oxygen therapy (LTOT) users (","_key":"3bea81611d950"},{"marks":["em"],"text":"P ","_key":"3bea81611d951","_type":"span"},{"_type":"span","marks":[],"text":"\u003c .0001). Therefore, symptom severity is a relevant factor for therapeutic intervention decisions in general hospitals. Conversely, treatment rates in referral hospitals were not associated with PS, mMRC score, or LTOT use; symptom severity is not considered when deciding on therapeutic intervention in this setting.","_key":"3bea81611d952"}],"_type":"block","style":"normal","_key":"6d62900c1858"},{"style":"normal","_key":"c6d313d6b853","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2143012e56060"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"The researchers acknowledged their limitations, one being that they conducted their study in a rural part of Japan rather than an urban area. Therefore, it cannot be considered an overall assessment of the country. Similarly, because it only analyzed patients within Japan, the findings may not be generalizable to other populations. Despite this, the researchers expressed confidence in their findings.","_key":"733fa6ec90cb0"}],"_type":"block","style":"normal","_key":"0fcce14fd947","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ec99bb31c7f20"}],"_type":"block","style":"normal","_key":"c123d1713c4c"},{"_key":"673ca5ee1f79","markDefs":[],"children":[{"text":"“Our findings indicate that further awareness of the indications for antifibrotic therapy in mild cases of IPF and collaboration between general and specialized hospitals are required,” the authors concluded.","_key":"6782f7edc4e90","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0dfe505ed68c0"}],"_type":"block","style":"normal","_key":"6912c26a1eb1"},{"_type":"block","style":"normal","_key":"7e5e3dae0a29","markDefs":[],"children":[{"_key":"de858caaf4a60","_type":"span","marks":["strong"],"text":"References"}]},{"listItem":"number","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Asami-Noyama M, Hamada K, Asai Y, et al. Factors associated with non-intervention of antifibrotic agents in IPF patients. ","_key":"0a33c3b7d7640"},{"_type":"span","marks":["em"],"text":"Respir Investig","_key":"0a33c3b7d7641"},{"_type":"span","marks":[],"text":". 2024;62(6):1124-1131. doi:10.1016/j.resinv.2024.09.008","_key":"0a33c3b7d7642"}],"level":1,"_type":"block","style":"normal","_key":"a3c3837dd0f9"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Raghu G, Rochwerg B, Zhang Y, et al. An official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline. ","_key":"06eba3e3756d"},{"_type":"span","marks":["em"],"text":"Am J Respir Crit Care Med","_key":"c4d9c2f6ec1f"},{"_type":"span","marks":[],"text":". 2015;192(2):e3-e19. doi:10.1164/rccm.201506-1063ST","_key":"22676122d674"}],"level":1,"_type":"block","style":"normal","_key":"b03312dca755","listItem":"number"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e4798401fcfa0"}],"_type":"block","style":"normal","_key":"61955594e8b9"},{"_type":"block","style":"normal","_key":"38a62e35034c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"195093f8dbb70"}]}],"contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"is_visible":true,"gptSummary":"Antifibrotic treatment for idiopathic pulmonary fibrosis (IPF) varies by facility, with significant differences in treatment rates between referral hospitals and general hospitals or clinics. Despite the benefits of pirfenidone and nintedanib, many patients with mild IPF remain untreated, often due to mild symptoms or imaging findings. The study, conducted in Yamaguchi, Japan, highlights the need for increased awareness of antifibrotic therapy indications and better collaboration between general and specialized hospitals. Limitations include the study's rural setting and its focus on a Japanese population, which may affect generalizability.","_type":"article","seoTag":["IPF","antifibrotic drugs","idiopathic pulmonary fibrosis","Pirfenidone ","nintedanib"],"factCheckAuthorMapping":null,"documentGroupMapping":null,"thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/c1bb1c8c-298c-4573-a961-9068b91850ac_1732720770117.50ff43f5-9727-480e-a7f6-bfe73ba01ca1.mp3","_createdAt":"2024-11-26T21:51:06Z","url":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","targeting":{"content_placement":["news","topic/clinical","compendium/ipf"],"document_url":["facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"published":"2024-11-27T17:30:00.000Z"},{"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","url":{"current":"decoding-sma-progression-hfmse-analysis-spotlights-variability","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"}},"published":"2024-11-27T17:11:13.855Z"},{"title":"2025 GOLD Report: New Insights on COPD Risks, Management","url":{"current":"2025-gold-report-new-insights-on-copd-risks-management","_type":"slug"},"thumbnail":{"asset":{"_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg","_type":"reference"},"_type":"mainImage","alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com"},"published":"2024-11-27T17:00:00.000Z"},{"title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","url":{"current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"}},"published":"2024-11-27T16:36:49.639Z"},{"title":"Trump Taps Bhattacharya to Lead National Institutes of Health","url":{"_type":"slug","current":"trump-taps-bhattacharya-to-lead-national-institutes-of-health"},"thumbnail":{"caption":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","asset":{"_ref":"image-7ac1cde025aed75c9e104813e932522251aca3ea-4576x3051-jpg","_type":"reference"},"_type":"mainImage","alt":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com"},"published":"2024-11-27T15:40:01.812Z"},{"title":"Navigating Healthcare Access and Decision-Making","url":{"current":"navigating-healthcare-access-and-decision-making","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_type":"reference","_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png"}},"published":"2024-11-27T14:12:30.463Z"}]},{"documentGroupMapping":null,"_id":"cbc5f68d-17f2-455e-9a61-f487bae7642e","summary":"Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.","taxonomyMapping":[{"name":"News","_updatedAt":"2022-01-19T10:20:16Z","identifier":"news","pixelTrackingCode":null,"_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","parent":null,"_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_createdAt":"2020-03-30T18:05:45Z"},{"usedForRecommendations":false,"_rev":"N7mKycgLbGtEq6btkPHYvR","name":"Center on Health Equity \u0026 Access","_createdAt":"2022-11-16T22:15:20Z","summary":[{"alignment":"left","asset":{"_ref":"image-5f5a1d7609b5e2167e8398bb48c8734b1ba7aca8-800x212-jpg","_type":"reference"},"widthP":70,"disableTextWrap":false,"disableLightBox":true,"_type":"figure","_key":"3b7c1e2bf551"},{"children":[{"_type":"span","marks":[],"text":"The mission of the Center on Health Equity \u0026 Access is to support improvement of health care delivery and health outcomes due to health disparities by maintaining a content platform focused on education, training, frontline perspectives, and practical application of evidence-based methodologies.","_key":"cdef2f34ef460"}],"_type":"block","style":"normal","_key":"973bcb0dcce4","markDefs":[]}],"parent":{"isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","identifier":"topic","_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","_updatedAt":"2021-10-21T10:15:35Z","parent":null},"pixelTrackingCode":null,"_updatedAt":"2024-06-12T13:58:15Z","thumbnail":{"_type":"mainImage","alt":"Logo for the Center on Health Equity \u0026 Access","asset":{"_ref":"image-5f5a1d7609b5e2167e8398bb48c8734b1ba7aca8-800x212-jpg","_type":"reference"}},"_type":"taxonomy","_id":"4ee49086-e720-4a65-883e-4efc24de53bb","identifier":"center-on-health-equity-and-access"},{"parent":{"name":"Topic","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","identifier":"topic","_createdAt":"2020-03-31T14:24:50Z","_rev":"SpZIJtjiAn4ebHE4u6sWYc","parent":null,"isMainTopic":true,"_type":"taxonomy"},"_createdAt":"2020-05-04T23:46:13Z","_type":"taxonomy","_id":"topic_healthcare-delivery","_updatedAt":"2022-11-29T18:34:57Z","pixelTrackingCode":null,"_rev":"52vAUxG62nnEnK65ZDo5dG","name":"Health Care Delivery","identifier":"healthcare-delivery"},{"_createdAt":"2020-05-04T23:46:13Z","_id":"topic_clinical","_updatedAt":"2022-02-18T12:13:55Z","identifier":"clinical","_rev":"HexDiduX8d6Nqnq1ECriVF","_type":"taxonomy","name":"Clinical","summary":[{"_type":"block","style":"normal","_key":"dd8ad578cd0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e80c79954e08"},{"_key":"a8e0f75c5d05","_type":"span","marks":["em"],"text":"AJMC"},{"text":"®","_key":"f7d4dddf7edd","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"cc409f2da7da"},{"_key":"2babb3e59bb3","_type":"span","marks":["superscript"],"text":"®"},{"marks":[],"text":" and ","_key":"d86a5bb12052","_type":"span"},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.","_key":"b59bef533cdf","_type":"span"}]}],"parent":{"identifier":"topic","_createdAt":"2020-03-31T14:24:50Z","_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","_updatedAt":"2021-10-21T10:15:35Z","isMainTopic":true,"_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","parent":null},"pixelTrackingCode":null},{"_rev":"xqhc4WIQcOa1P2rns6bqkh","_updatedAt":"2023-10-30T17:48:32Z","identifier":"interviews","parent":null,"pixelTrackingCode":null,"_type":"taxonomy","name":"Interviews","_id":"2d909731-8acf-4e3d-8962-d59b0da85320","_createdAt":"2020-03-30T19:16:54Z","sortOrder":3},{"_rev":"eSLt1H4Q02CJepCoBcV8k7","_type":"taxonomy","name":"Podcasts","_id":"91634056-f475-4f1f-b2c6-a28eaa2caa0d","_updatedAt":"2022-01-06T09:14:16Z","parent":null,"identifier":"podcasts","_createdAt":"2021-02-16T18:21:54Z","pixelTrackingCode":null},{"_rev":"MOpgYXzgf2PXCUGhoNCh0S","_id":"a3fc756d-9cf3-4cbf-9174-96d1490f19d2","_updatedAt":"2022-12-21T19:49:08Z","parent":{"name":"Podcasts","_id":"91634056-f475-4f1f-b2c6-a28eaa2caa0d","parent":null,"_updatedAt":"2022-01-06T09:14:16Z","identifier":"podcasts","_createdAt":"2021-02-16T18:21:54Z","_rev":"eSLt1H4Q02CJepCoBcV8k7","_type":"taxonomy"},"sortOrder":1,"name":"Managed Care Cast","pixelTrackingCode":null,"identifier":"managed-care-cast","_type":"taxonomy","_createdAt":"2020-03-30T19:18:44Z"},{"_updatedAt":"2024-02-06T14:51:54Z","parent":{"_rev":"oruil6rlosjyltJbhrNMGF","name":"Compendium","_updatedAt":"2024-04-09T09:14:18Z","parent":null,"_createdAt":"2020-03-30T18:16:46Z","_type":"taxonomy","_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","identifier":"compendium","isMainTopic":true},"_rev":"YJ241YIfAGTBo8chKefC24","name":"Immunology","_id":"6d6b15f1-03be-48ce-a456-8c210476894f","pixelTrackingCode":null,"video":{"isTaxVideo":false},"_createdAt":"2024-02-06T14:51:54Z","usedForRecommendations":false,"_type":"taxonomy","identifier":"immunology"}],"audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/cbc5f68d-17f2-455e-9a61-f487bae7642e_1730209133762.77baa297-d2c2-432d-b03e-23337d6426de.mp3","authors":[{"displayName":"Giuliana Grossi","url":"giuliana-grossi"}],"factCheckAuthorMapping":null,"documentGroup":null,"_createdAt":"2024-10-28T21:01:28Z","published":"2024-10-29T14:00:00.000Z","title":"Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa","articleType":"Commentary","contentCategory":{"_id":"367becaf-13c4-4502-9c8c-939f4f480898","_updatedAt":"2021-08-12T18:05:19Z","_createdAt":"2020-04-03T20:07:37Z","_rev":"DuxacMYwkIxWPw8NDZCeiZ","_type":"contentCategory","name":"Podcasts","disableAds":false},"_rev":"IlIq0JCGGmrvSiDdug7vc5","url":"breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa","_updatedAt":"2024-11-01T15:02:38Z","_type":"article","seoTag":["hidradenitis suppurativa","HS","Dermatology","Early intervention","Biologics"],"authorMapping":[{"_createdAt":"2023-06-23T19:52:20Z","_rev":"sgy4yN0CjmArmRDnE2KYhI","_type":"author","_id":"8e597e29-c3ad-470c-8174-00c81b563f81","profileImage":{"_type":"mainImage","alt":"Giuliana Grossi","asset":{"_ref":"image-5dc1da24786c43a7f87e4ea0a7ae3880e6cee39f-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:25:19Z","url":{"_type":"slug","current":"giuliana-grossi"},"displayName":"Giuliana Grossi"}],"factCheckAuthors":null,"thumbnail":{"_type":"mainImage","alt":"Managed Care Cast","asset":{"_ref":"image-4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563-jpg","_type":"reference"}},"body":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Early intervention is essential in treating hidradenitis suppurativa (HS) due to its progressive nature and potential for severe physical and psychological impact. HS, a chronic inflammatory skin condition, often begins with painful nodules that can worsen without timely treatment, leading to abscesses, scarring, and sinus tract formation. ","_key":"434df8db03a40"}],"_type":"block","style":"normal","_key":"9921eb4038b1"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5c782d6e61fe"}],"_type":"block","style":"normal","_key":"5a742b763a91"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"In this episode, Jerry Bagel, MD, Schweiger Dermatology, explains why delaying intervention increases the risk of complications and decreases the effectiveness of available therapies, making symptoms harder to manage over time. Updated guideline recommendations encouraging early intervention can help slow disease progression, alleviate pain, and improve quality of life. ","_key":"c88a7a69cc9a"}],"_type":"block","style":"normal","_key":"b8a6b7262694"},{"style":"normal","_key":"5387173cef39","markDefs":[],"children":[{"text":"","_key":"52dba15a2e10","_type":"span","marks":[]}],"_type":"block"},{"_type":"iframe","_key":"65fc0bf8e9a4","url":"https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/tracks/1944283455%3Fsecret_token%3Ds-K742ZROSs0M\u0026color=%23ff5500\u0026auto_play=false\u0026hide_related=false\u0026show_comments=true\u0026show_user=true\u0026show_reposts=false\u0026show_teaser=true\u0026visual=true"},{"style":"normal","_key":"100af5292a9b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Listen above or on one of these podcast services:","_key":"d70c7bf3e4330"}],"_type":"block"},{"_key":"e53f608ef035","markDefs":[{"_key":"11c2e130ff7f","nofollow":true,"blank":true,"_type":"link","href":"https://podcasts.apple.com/us/podcast/managed-care-cast/id1177540313"},{"_type":"link","href":"https://tunein.com/podcasts/Health--Wellness-Podcasts/Managed-Care-Cast-p937637/","_key":"b0667184f0a1","nofollow":true,"blank":true},{"nofollow":true,"blank":true,"_type":"link","href":"https://www.stitcher.com/podcast/managed-care-cast","_key":"55f25b1f2037"},{"href":"https://open.spotify.com/show/7JQZGTuflqnkt8wjfX238y","_key":"a1110de0fabd","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":["11c2e130ff7f"],"text":"iTunes","_key":"896ad35d52270"},{"_type":"span","marks":[],"text":"\n","_key":"896ad35d52271"},{"_type":"span","marks":["b0667184f0a1"],"text":"TuneIn","_key":"896ad35d52272"},{"_type":"span","marks":[],"text":"\n","_key":"896ad35d52273"},{"_type":"span","marks":["55f25b1f2037"],"text":"Stitcher","_key":"896ad35d52274"},{"_type":"span","marks":[],"text":"\n","_key":"896ad35d52275"},{"_type":"span","marks":["a1110de0fabd"],"text":"Spotify","_key":"896ad35d52276"}],"_type":"block","style":"normal"}],"ExcludeFromPubMedXML":false,"is_visible":true,"targeting":{"content_placement":["news","topic/center-on-health-equity-and-access","topic/healthcare-delivery","topic/clinical","interviews","podcasts","podcasts/managed-care-cast","compendium/immunology"],"document_url":["breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"published":"2024-11-27T17:30:00.000Z"},{"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","url":{"_type":"slug","current":"decoding-sma-progression-hfmse-analysis-spotlights-variability"},"thumbnail":{"_type":"mainImage","alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"}},"published":"2024-11-27T17:11:13.855Z"},{"title":"2025 GOLD Report: New Insights on COPD Risks, Management","url":{"current":"2025-gold-report-new-insights-on-copd-risks-management","_type":"slug"},"thumbnail":{"alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com","asset":{"_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg","_type":"reference"},"_type":"mainImage"},"published":"2024-11-27T17:00:00.000Z"},{"title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","url":{"current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_type":"reference","_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg"}},"published":"2024-11-27T16:36:49.639Z"},{"title":"Operationalizing Bispecifics in Multiple Myeloma","url":{"current":"operationalizing-bispecifics-in-multiple-myeloma","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"managed care cast logo","asset":{"_ref":"image-9de113904a026205cbaf84d08420c4065d52fd67-1000x563-jpg","_type":"reference"}},"published":"2024-11-27T16:00:00.000Z"},{"title":"Trump Taps Bhattacharya to Lead National Institutes of Health","url":{"current":"trump-taps-bhattacharya-to-lead-national-institutes-of-health","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","caption":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","asset":{"_ref":"image-7ac1cde025aed75c9e104813e932522251aca3ea-4576x3051-jpg","_type":"reference"}},"published":"2024-11-27T15:40:01.812Z"}]},{"_type":"article","title":"Social Isolation Linked to Increased Mortality in Patients With COPD","_createdAt":"2024-11-26T13:30:00Z","contentCategory":{"_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2"},"url":"social-isolation-linked-to-increased-mortality-in-patients-with-copd","is_visible":true,"taxonomyMapping":[{"pixelTrackingCode":null,"_rev":"OU32WOWh4YetHW0RkWbkso","name":"News","identifier":"news","_createdAt":"2020-03-30T18:05:45Z","parent":null,"_type":"taxonomy","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z"},{"parent":{"_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","parent":null,"identifier":"topic","isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z"},"name":"Clinical","identifier":"clinical","_createdAt":"2020-05-04T23:46:13Z","_rev":"HexDiduX8d6Nqnq1ECriVF","summary":[{"_type":"block","style":"normal","_key":"dd8ad578cd0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e80c79954e08"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"a8e0f75c5d05"},{"marks":["superscript"],"text":"®","_key":"f7d4dddf7edd","_type":"span"},{"marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"cc409f2da7da"},{"marks":["superscript"],"text":"®","_key":"2babb3e59bb3","_type":"span"},{"marks":[],"text":" and ","_key":"d86a5bb12052","_type":"span"},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"_type":"span","marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.","_key":"b59bef533cdf"}]}],"_type":"taxonomy","_id":"topic_clinical","_updatedAt":"2022-02-18T12:13:55Z","pixelTrackingCode":null},{"summary":[{"_key":"9e4d972ab8f4","markDefs":[],"children":[{"_key":"b4d2ad289361","_type":"span","marks":[],"text":"The "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"ce01dbe41d46"},{"_type":"span","marks":["superscript"],"text":"®","_key":"2645ce587e71"},{"_type":"span","marks":[],"text":" COPD compendium is a comprehensive resource for clinical news and expert insights for chronic obstructive pulmonary disease.","_key":"390da946552d"}],"_type":"block","style":"normal"}],"cmeType":"per","perKeywordMapping":["Pulmonology","Health Equity Diversity \u0026 Inclusion"],"_id":"compendium_copd","_updatedAt":"2023-11-03T18:24:36Z","name":"COPD ","identifier":"copd","parent":{"_updatedAt":"2024-04-09T09:14:18Z","_type":"taxonomy","name":"Compendium","parent":null,"_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","identifier":"compendium","isMainTopic":true,"_createdAt":"2020-03-30T18:16:46Z","_rev":"oruil6rlosjyltJbhrNMGF"},"_createdAt":"2020-04-14T15:02:13Z","_type":"taxonomy","pixelTrackingCode":null,"_rev":"J9E0v654gKdSlGLhTDDHgy"}],"seoTag":["COPD","social isolation"],"summary":"Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD), highlighting the need for targeted interventions to address this issue.","thumbnail":{"_type":"mainImage","alt":"Lonely patient | Image Credit: amazing studio - stock.adobe.com","asset":{"_ref":"image-3e5c760c89948ea062bc8055186b9134ab330099-3498x2332-jpg","_type":"reference"}},"factCheckAuthorMapping":null,"body":[{"_type":"block","style":"normal","_key":"9ec207c156c3","markDefs":[{"blank":true,"_type":"link","href":"https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2825360?resultClick=1","_key":"7924afdbf132","nofollow":true},{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/copd","_key":"f8f5eaabc4e3"}],"children":[{"_type":"span","marks":[],"text":"Social isolation is independently associated with increased mortality in patients with ","_key":"53fe663f11f00"},{"_key":"3ba47d3088d2","_type":"span","marks":["f8f5eaabc4e3"],"text":"chronic obstructive pulmonary disease (COPD)"},{"_type":"span","marks":[],"text":", according to a research letter published in ","_key":"e97a2cdd4046"},{"_type":"span","marks":["7924afdbf132","em"],"text":"JAMA Internal Medicine","_key":"53fe663f11f01"},{"_type":"span","marks":["em"],"text":".","_key":"53fe663f11f02"},{"text":"1","_key":"a660340cb1d0","_type":"span","marks":["superscript"]}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5b67470bd7900"}],"_type":"block","style":"normal","_key":"87e51d0a4c49"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Social isolation, an objective state of limited to no social contact, has been linked to poor health outcomes and mortality among those aged 65 or older. Also, about 1 in 5 people with COPD experience social isolation, which is about twice as much as older adults overall. The researchers attributed this increase in social isolation to disease features, like breathlessness and reduced physical function.","_key":"f3dab0502db60"}],"_type":"block","style":"normal","_key":"aaccb6b585f1"},{"_key":"0a7af4acb511","markDefs":[],"children":[{"marks":[],"text":"","_key":"4751709591650","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"However, the association of social isolation in COPD with downstream outcomes, like mortality, has not been examined. Consequently, the researchers investigated the association between social isolation and all-cause mortality in a nationally representative cohort of US adults with COPD.","_key":"1b0ea77b76fd0"}],"_type":"block","style":"normal","_key":"d76bb7775fab","markDefs":[]},{"_key":"25f507c99ce3","disableTextWrap":false,"_type":"figure","alt":"Lonely patient | Image Credit: amazing studio - stock.adobe.com","asset":{"_ref":"image-3e5c760c89948ea062bc8055186b9134ab330099-3498x2332-jpg","_type":"reference"},"widthP":40,"imgcaption":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD). | Image Credit: amazing studio - stock.adobe.com","_key":"edc92c349891"}],"_type":"block","style":"normal","_key":"e0e2770b4a9e"}],"disableLightBox":true,"alignment":"right"},{"_key":"ff92fda7e0e0","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://academic.oup.com/ije/article-abstract/43/2/576/2901743?redirectedFrom=fulltext","_key":"df3fe86ca57f"}],"children":[{"_type":"span","marks":[],"text":"They ","_key":"3a3828d146090"},{"_type":"span","marks":["df3fe86ca57f"],"text":"used","_key":"c531133b6f8b"},{"_type":"span","marks":[],"text":" data from the Health and Retirement Survey (HRS), focusing on adults aged 51 or older, with the dataset spanning 2006 to 2022.","_key":"0ead5596db24"},{"text":"2","_key":"429e0d223947","_type":"span","marks":["superscript"]},{"marks":[],"text":" Additionally, the researchers used a previously published social isolation scale, which included metrics like being unmarried, lacking community participation, living alone, and having no social contact with children, family, or friends.","_key":"659d5af1acda","_type":"span"},{"_type":"span","marks":["superscript"],"text":"1","_key":"c146d2e8dfa9"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7108976c8b440"}],"_type":"block","style":"normal","_key":"2c302c9201a4"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Individuals received 1 point for each applicable metric, with scores ranging from 0 to 6. Those with 3 points or more were classified as experiencing social isolation. The researchers noted that participants were included at the first available wave in which they self-reported COPD and answered at least 3 questions related to social isolation.","_key":"774bce287f390"}],"_type":"block","style":"normal","_key":"36b241a75d00"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"fe2f81665c4c0"}],"_type":"block","style":"normal","_key":"b08eb8c285c6"},{"_key":"8ccf59deb9bb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"All-cause mortality was determined using HRS date-of-death measures. Cox proportional hazard models were then used to determine the association between social isolation and all-cause mortality, adjusting for age, race, sex, and ethnicity, which have previously been associated with social isolation.","_key":"df4927f8fef80"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4ade442bd8d00"}],"_type":"block","style":"normal","_key":"dd06cf11b8c2"},{"children":[{"_type":"span","marks":[],"text":"The study population consisted of 1241 participants, with a mean (SD) age of 68.4 (9.8) years; the majority was female (59.3%). Of these participants, 293 (23.6%) reported experiencing social isolation. Additionally, 539 participants (43.4%) died after a median follow-up of 4.4 years (range, 0.1-14.6 years).","_key":"48351ba598330"}],"_type":"block","style":"normal","_key":"06ad69063af8","markDefs":[]},{"_type":"block","style":"normal","_key":"56dae2dd0f40","markDefs":[],"children":[{"text":"","_key":"894f2dfd41e70","_type":"span","marks":[]}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Those with COPD and social isolation were at an increased risk of death (unadjusted HR, 1.35; 95% CI, 1.08-169; adjusted HR, 1.35; 95% CI, 1.04-1.75) than those without social isolation. Therefore, median survival time was lower among socially isolated participants (7.0 years; 95% CI, 5.8-8.2) vs those not socially isolated (9.1 years; 95% CI, 8.3-10.4). Similarly, the 5-year survival rate among socially isolated participants (62.9%; 95% CI, 56.6-68.6) was lower than that of those not socially isolated (71.1%; 95% CI, 67.7-74.1).","_key":"9bfcb9e368860"}],"_type":"block","style":"normal","_key":"9f7adc54e414"},{"children":[{"_type":"span","marks":[],"text":"","_key":"8262dc6900c20"}],"_type":"block","style":"normal","_key":"b9a96716f5b5","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"“We hypothesize that social isolation may increase mortality risk in COPD by limiting access to necessary support and resources for managing debilitating symptoms such as breathlessness, functional limitations, and complex medical regimens, particularly after hospital or intensive care unit stays,” the authors wrote.","_key":"4046d8b0951f0"}],"_type":"block","style":"normal","_key":"b625550b3317","markDefs":[]},{"_key":"80b317da5ebe","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0d7d57967c140"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Consequently, the researchers emphasized that addressing social isolation through expanded interdisciplinary efforts could improve well-being and provide resources to help proactively plan for health crises. Potential interventions include support groups, group-based pulmonary rehabilitation, and behavioral activation to promote self-efficacy.","_key":"0694c4963aa4"}],"_type":"block","style":"normal","_key":"8a738e31fc75"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"4077d9e200800","_type":"span"}],"_type":"block","style":"normal","_key":"434fde22a961"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Lastly, the researchers acknowledged their limitations, one being that patients self-reported COPD diagnoses. This could capture other less common chronic lung diseases, like interstitial lung disease. Despite their limitations, they expressed confidence in their findings, using them to suggest areas for further research.","_key":"b27b91efadcf0"}],"_type":"block","style":"normal","_key":"4df8e0a8ffe4"},{"_type":"block","style":"normal","_key":"f5ac20cd02ba","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e30e6c05ba5e0"}]},{"_key":"d1ca997ed31c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Future studies should investigate strategies to reduce social isolation among patients with COP and whether these efforts may improve health outcomes,” the authors concluded.","_key":"778110f33f290"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"82ebacc3b9d5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"996ce252c60c0"}]},{"_key":"e7ad051d6be4","markDefs":[],"children":[{"_key":"9f22b32202600","_type":"span","marks":["strong"],"text":"References"}],"_type":"block","style":"normal"},{"listItem":"number","markDefs":[],"children":[{"_key":"eb82313a14a40","_type":"span","marks":[],"text":"Suen AO, Iyer AS, Cenzer I, et al. Social isolation and mortality in adults with chronic obstructive pulmonary disease. "},{"_type":"span","marks":["em"],"text":"JAMA Intern Med","_key":"eb82313a14a41"},{"_type":"span","marks":[],"text":". doi:10.1001/jamainternmed.2024.5940","_key":"eb82313a14a42"}],"level":1,"_type":"block","style":"normal","_key":"f894e579ab5f"},{"level":1,"_type":"block","style":"normal","_key":"372ed117fdf4","listItem":"number","markDefs":[],"children":[{"_key":"323a4a091745","_type":"span","marks":[],"text":"Sonnega A, Faul JD, Ofstedal MB, Langa KM, Phillips JW, Weir DR. Cohort profile: the health and retirement Study (HRS). "},{"_type":"span","marks":["em"],"text":"Int J Epidemiol","_key":"246ce93fe6441"},{"_type":"span","marks":[],"text":". 2014;43(2):576-585. doi:10.1093/ije/dyu067","_key":"246ce93fe6442"}]}],"articleType":"News","authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"_rev":"PlC7YDkXkx05WZqKmSXApB","published":"2024-11-26T15:30:03.778Z","documentGroupMapping":null,"factCheckAuthors":null,"documentGroup":null,"ExcludeFromPubMedXML":false,"_updatedAt":"2024-11-26T14:11:01Z","_id":"e8936d34-fea1-40ed-96bb-67267a8d2bfd","authorMapping":[{"profileImage":{"_type":"mainImage","alt":"Brooke McCormick","asset":{"_ref":"image-1fe4e81696463cdd9c1d6b62a2e47c2228d7df99-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:29:20Z","displayName":"Brooke McCormick","_type":"author","_id":"00af9d05-a2c4-4451-a6d1-0e28b08cbb65","biography":[{"_key":"936ecf4b7f0c","markDefs":[],"children":[{"marks":[],"text":"Brooke is an assistant editor for ","_key":"8d68730a8da0","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"730c46c984c9"},{"_type":"span","marks":[],"text":"® (","_key":"0b218fbaa571"},{"_key":"b1b5b3d9cff0","_type":"span","marks":["em"],"text":"AJMC"},{"_type":"span","marks":[],"text":"®). She joined ","_key":"7de919198f04"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"f31a60d737e2"},{"_type":"span","marks":[],"text":" in 2023, where she produces written content covering multiple disease states.","_key":"df11193684f8"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"5731fbb8e0ae","_type":"span"}],"_type":"block","style":"normal","_key":"9af540ce04de"},{"markDefs":[{"blank":true,"_type":"link","href":"https://www.linkedin.com/in/brooke-mccormick-1a254b1b6/","_key":"80a1c1a9d7cd","nofollow":true}],"children":[{"marks":[],"text":"She has a BA in journalism from Seton Hall University. You can connect with Brooke on ","_key":"bb68b5e8ee83","_type":"span"},{"_type":"span","marks":["80a1c1a9d7cd"],"text":"LinkedIn","_key":"4bb222fe2840"},{"_type":"span","marks":[],"text":".","_key":"c87621477700"}],"_type":"block","style":"normal","_key":"98aee68dab9d"}],"url":{"current":"brooke-mccormick","_type":"slug"},"firstName":"Brooke","lastName":"McCormick","_createdAt":"2023-06-21T17:59:19Z","_rev":"m9zO7fOEUWAduYt5irO78Q"}],"targeting":{"content_placement":["news","topic/clinical","compendium/copd"],"document_url":["social-isolation-linked-to-increased-mortality-in-patients-with-copd"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"published":"2024-11-27T17:30:00.000Z"},{"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","url":{"current":"decoding-sma-progression-hfmse-analysis-spotlights-variability","_type":"slug"},"thumbnail":{"caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"},"_type":"mainImage","alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com"},"published":"2024-11-27T17:11:13.855Z"},{"title":"2025 GOLD Report: New Insights on COPD Risks, Management","url":{"_type":"slug","current":"2025-gold-report-new-insights-on-copd-risks-management"},"thumbnail":{"_type":"mainImage","alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com","asset":{"_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg","_type":"reference"}},"published":"2024-11-27T17:00:00.000Z"},{"title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","url":{"current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"}},"published":"2024-11-27T16:36:49.639Z"},{"title":"Trump Taps Bhattacharya to Lead National Institutes of Health","url":{"current":"trump-taps-bhattacharya-to-lead-national-institutes-of-health","_type":"slug"},"thumbnail":{"asset":{"_ref":"image-7ac1cde025aed75c9e104813e932522251aca3ea-4576x3051-jpg","_type":"reference"},"_type":"mainImage","alt":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","caption":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com"},"published":"2024-11-27T15:40:01.812Z"},{"title":"Navigating Healthcare Access and Decision-Making","url":{"current":"navigating-healthcare-access-and-decision-making","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"published":"2024-11-27T14:12:30.463Z"}]},{"title":"Insurance Insights: Dr Jason Shafrin Estimates DMD Insurance Value","taxonomyMapping":[{"_type":"taxonomy","name":"News","pixelTrackingCode":null,"identifier":"news","_createdAt":"2020-03-30T18:05:45Z","_rev":"OU32WOWh4YetHW0RkWbkso","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z","parent":null},{"_id":"37e5df5f-ce01-4688-b5ed-61e9014798c8","video":{"isTaxVideo":false},"_updatedAt":"2023-09-08T14:57:44Z","_rev":"I69RE849GmtXmLZyCReWIJ","_createdAt":"2023-08-21T19:16:01Z","_type":"taxonomy","parent":{"parent":null,"_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_rev":"oruil6rlosjyltJbhrNMGF","isMainTopic":true,"_createdAt":"2020-03-30T18:16:46Z","_type":"taxonomy","name":"Compendium","_updatedAt":"2024-04-09T09:14:18Z","identifier":"compendium"},"name":"Duchenne Muscular Dystrophy","usedForRecommendations":false,"identifier":"dmd","pixelTrackingCode":null},{"_id":"91634056-f475-4f1f-b2c6-a28eaa2caa0d","_type":"taxonomy","name":"Podcasts","pixelTrackingCode":null,"_updatedAt":"2022-01-06T09:14:16Z","identifier":"podcasts","_createdAt":"2021-02-16T18:21:54Z","_rev":"eSLt1H4Q02CJepCoBcV8k7","parent":null},{"_updatedAt":"2023-10-30T17:48:32Z","identifier":"interviews","_createdAt":"2020-03-30T19:16:54Z","sortOrder":3,"pixelTrackingCode":null,"_rev":"xqhc4WIQcOa1P2rns6bqkh","_id":"2d909731-8acf-4e3d-8962-d59b0da85320","parent":null,"_type":"taxonomy","name":"Interviews"},{"name":"Clinical","_id":"topic_clinical","identifier":"clinical","pixelTrackingCode":null,"_type":"taxonomy","parent":{"_updatedAt":"2021-10-21T10:15:35Z","identifier":"topic","isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","_rev":"SpZIJtjiAn4ebHE4u6sWYc","_type":"taxonomy","name":"Topic","_id":"15012229-f713-4f0a-8f82-7667530bb382","parent":null},"_createdAt":"2020-05-04T23:46:13Z","_rev":"HexDiduX8d6Nqnq1ECriVF","_updatedAt":"2022-02-18T12:13:55Z","summary":[{"_type":"block","style":"normal","_key":"dd8ad578cd0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e80c79954e08"},{"_key":"a8e0f75c5d05","_type":"span","marks":["em"],"text":"AJMC"},{"text":"®","_key":"f7d4dddf7edd","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"cc409f2da7da"},{"_key":"2babb3e59bb3","_type":"span","marks":["superscript"],"text":"®"},{"marks":[],"text":" and ","_key":"d86a5bb12052","_type":"span"},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.","_key":"b59bef533cdf","_type":"span"}]}]},{"_updatedAt":"2020-07-30T14:47:46Z","identifier":"insurance","_rev":"GQ2iWOdzjKwgYpKUFVt5oL","pixelTrackingCode":null,"name":"Insurance","_id":"topic_insurance","parent":{"identifier":"topic","isMainTopic":true,"_rev":"SpZIJtjiAn4ebHE4u6sWYc","_type":"taxonomy","name":"Topic","_id":"15012229-f713-4f0a-8f82-7667530bb382","parent":null,"_createdAt":"2020-03-31T14:24:50Z","_updatedAt":"2021-10-21T10:15:35Z"},"_createdAt":"2020-05-04T23:46:13Z","_type":"taxonomy"},{"name":"Health Care Cost","identifier":"healthcare-cost","pixelTrackingCode":null,"parent":{"isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","name":"Topic","identifier":"topic","_rev":"SpZIJtjiAn4ebHE4u6sWYc","_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","parent":null},"_createdAt":"2020-05-04T23:46:13Z","_rev":"52vAUxG62nnEnK65ZDnwlC","_type":"taxonomy","_id":"topic_healthcare-cost","_updatedAt":"2022-11-29T18:34:38Z"}],"_id":"27bb922d-964a-4ef7-9da4-2fc7e14d2a2c","factCheckAuthors":null,"thumbnail":{"_type":"mainImage","alt":"Managed Care Cast logo","asset":{"_type":"reference","_ref":"image-453ff95d3edc29442e2af71658751e2f26adc78e-2500x2500-jpg"}},"body":[{"children":[{"_type":"span","marks":[],"text":"On this episode of Managed Care Cast, we're talking with Jason Shafrin, PhD, the senior managing director of FTI Consulting's Center for Healthcare Economics and Policy and an adjunct professor in the University of Southern California's Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences.","_key":"d391614d7736"}],"_type":"block","style":"normal","_key":"8b624163466a","markDefs":[]},{"children":[{"marks":[],"text":"","_key":"ddcb59176621","_type":"span"}],"_type":"block","style":"normal","_key":"275ff7f8e387","markDefs":[]},{"markDefs":[{"_key":"2d4e845ac5db","nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/view/quantifying-the-insurance-value-for-rare-diseases-duchenne-muscular-dystrophy"},{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/dmd","_key":"4c0d1755b31a"}],"children":[{"_type":"span","marks":[],"text":"His study, \"","_key":"40722353622e"},{"_type":"span","marks":["2d4e845ac5db"],"text":"Quantifying the Insurance Value for Rare Diseases: Duchenne Muscular Dystrophy","_key":"6b91158b85cb"},{"marks":[],"text":",\" estimates the insurance value of novel ","_key":"53c694bf4420","_type":"span"},{"text":"Duchenne muscular dystrophy (DMD)","_key":"5945c3f29bfc","_type":"span","marks":["4c0d1755b31a"]},{"_type":"span","marks":[],"text":" treatment from a survey of individuals planning to have children.","_key":"372770d53267"}],"_type":"block","style":"normal","_key":"0f02a786b97d"},{"children":[{"_type":"span","marks":[],"text":"","_key":"0cdffa4776b7"}],"_type":"block","style":"normal","_key":"faefa9f33fe9","markDefs":[]},{"url":"https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/tracks/1873189599%3Fsecret_token%3Ds-uTtMy5psfpb\u0026color=%23ff5500\u0026auto_play=false\u0026hide_related=false\u0026show_comments=true\u0026show_user=true\u0026show_reposts=false\u0026show_teaser=true\u0026visual=true","_type":"iframe","_key":"81b814437b41"},{"children":[{"_type":"span","marks":[],"text":"","_key":"5126b56ccc21"}],"_type":"block","style":"normal","_key":"3548590d94c9","markDefs":[]},{"style":"normal","_key":"3b2577a801c1","markDefs":[],"children":[{"text":"Listen above or on one of these podcast services:","_key":"1a69111408b70","_type":"span","marks":[]}],"_type":"block"},{"_key":"ca548655907f","markDefs":[{"_type":"link","href":"https://podcasts.apple.com/us/podcast/managed-care-cast/id1177540313","_key":"80f2a72507ea","nofollow":true,"blank":true},{"href":"https://tunein.com/podcasts/Health--Wellness-Podcasts/Managed-Care-Cast-p937637/","_key":"2a1ab853c8e9","nofollow":true,"blank":true,"_type":"link"},{"nofollow":true,"blank":true,"_type":"link","href":"https://www.stitcher.com/podcast/managed-care-cast","_key":"25a3bac107a0"},{"blank":true,"_type":"link","href":"https://open.spotify.com/show/7JQZGTuflqnkt8wjfX238y","_key":"0ec22eaea488","nofollow":true}],"children":[{"text":"iTunes","_key":"97c8704311aa0","_type":"span","marks":["80f2a72507ea"]},{"text":"\n","_key":"97c8704311aa1","_type":"span","marks":[]},{"_key":"97c8704311aa2","_type":"span","marks":["2a1ab853c8e9"],"text":"TuneIn"},{"_key":"97c8704311aa3","_type":"span","marks":[],"text":"\n"},{"_type":"span","marks":["25a3bac107a0"],"text":"Stitcher","_key":"97c8704311aa4"},{"_key":"97c8704311aa5","_type":"span","marks":[],"text":"\n"},{"_type":"span","marks":["0ec22eaea488"],"text":"Spotify","_key":"97c8704311aa6"}],"_type":"block","style":"normal"}],"_updatedAt":"2024-07-16T17:43:27Z","contentCategory":{"disableAds":false,"_id":"367becaf-13c4-4502-9c8c-939f4f480898","_updatedAt":"2021-08-12T18:05:19Z","_createdAt":"2020-04-03T20:07:37Z","_rev":"DuxacMYwkIxWPw8NDZCeiZ","_type":"contentCategory","name":"Podcasts"},"_createdAt":"2024-07-16T15:03:51Z","authorMapping":[{"_updatedAt":"2024-05-20T19:29:20Z","_rev":"m9zO7fOEUWAduYt5irO78Q","_type":"author","biography":[{"_type":"block","style":"normal","_key":"936ecf4b7f0c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Brooke is an assistant editor for ","_key":"8d68730a8da0"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"730c46c984c9"},{"_type":"span","marks":[],"text":"® (","_key":"0b218fbaa571"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b1b5b3d9cff0"},{"_key":"7de919198f04","_type":"span","marks":[],"text":"®). She joined "},{"text":"AJMC","_key":"f31a60d737e2","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" in 2023, where she produces written content covering multiple disease states.","_key":"df11193684f8"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"5731fbb8e0ae"}],"_type":"block","style":"normal","_key":"9af540ce04de","markDefs":[]},{"style":"normal","_key":"98aee68dab9d","markDefs":[{"href":"https://www.linkedin.com/in/brooke-mccormick-1a254b1b6/","_key":"80a1c1a9d7cd","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"She has a BA in journalism from Seton Hall University. You can connect with Brooke on ","_key":"bb68b5e8ee83"},{"_type":"span","marks":["80a1c1a9d7cd"],"text":"LinkedIn","_key":"4bb222fe2840"},{"_type":"span","marks":[],"text":".","_key":"c87621477700"}],"_type":"block"}],"_createdAt":"2023-06-21T17:59:19Z","_id":"00af9d05-a2c4-4451-a6d1-0e28b08cbb65","profileImage":{"_type":"mainImage","alt":"Brooke McCormick","asset":{"_ref":"image-1fe4e81696463cdd9c1d6b62a2e47c2228d7df99-430x430-png","_type":"reference"}},"url":{"current":"brooke-mccormick","_type":"slug"},"firstName":"Brooke","lastName":"McCormick","displayName":"Brooke McCormick"}],"summary":"On this episode of Managed Care Cast, we're talking with the author of a study published in the July 2024 issue of The American Journal of Managed Care® that estimates the insurance value of novel Duchenne muscular dystrophy (DMD) treatment.","documentGroupMapping":null,"is_visible":true,"articleType":"Commentary","seoTag":["managed care cast","dr jason shafrin","DMD"],"ExcludeFromPubMedXML":false,"_rev":"ePtJfMQr1RnmnhtjqENfq0","published":"2024-07-18T13:00:00.000Z","_type":"article","authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"factCheckAuthorMapping":null,"documentGroup":null,"url":"insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value","targeting":{"content_placement":["news","compendium/dmd","podcasts","interviews","topic/clinical","topic/insurance","topic/healthcare-cost"],"document_url":["insurance-insights-dr-jason-shafrin-estimates-dmd-insurance-value"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"published":"2024-11-27T17:30:00.000Z"},{"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","url":{"current":"decoding-sma-progression-hfmse-analysis-spotlights-variability","_type":"slug"},"thumbnail":{"caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"},"_type":"mainImage","alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com"},"published":"2024-11-27T17:11:13.855Z"},{"title":"2025 GOLD Report: New Insights on COPD Risks, Management","url":{"_type":"slug","current":"2025-gold-report-new-insights-on-copd-risks-management"},"thumbnail":{"_type":"mainImage","alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com","asset":{"_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg","_type":"reference"}},"published":"2024-11-27T17:00:00.000Z"},{"title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","url":{"current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"}},"published":"2024-11-27T16:36:49.639Z"},{"title":"Operationalizing Bispecifics in Multiple Myeloma","url":{"_type":"slug","current":"operationalizing-bispecifics-in-multiple-myeloma"},"thumbnail":{"_type":"mainImage","alt":"managed care cast logo","asset":{"_type":"reference","_ref":"image-9de113904a026205cbaf84d08420c4065d52fd67-1000x563-jpg"}},"published":"2024-11-27T16:00:00.000Z"},{"title":"Trump Taps Bhattacharya to Lead National Institutes of Health","url":{"current":"trump-taps-bhattacharya-to-lead-national-institutes-of-health","_type":"slug"},"thumbnail":{"alt":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","caption":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","asset":{"_ref":"image-7ac1cde025aed75c9e104813e932522251aca3ea-4576x3051-jpg","_type":"reference"},"_type":"mainImage"},"published":"2024-11-27T15:40:01.812Z"}]},{"articleType":"News","seoTag":["rare blood","compendia","CAR-T","ixazomib"],"contentCategory":{"_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles"},"_rev":"YGlLVDrzBhKaX9zB0MzQsM","authors":[{"displayName":"Giuliana Grossi","url":"giuliana-grossi"}],"factCheckAuthorMapping":null,"authorMapping":[{"displayName":"Giuliana Grossi","_createdAt":"2023-06-23T19:52:20Z","_rev":"sgy4yN0CjmArmRDnE2KYhI","_type":"author","_id":"8e597e29-c3ad-470c-8174-00c81b563f81","profileImage":{"_type":"mainImage","alt":"Giuliana Grossi","asset":{"_ref":"image-5dc1da24786c43a7f87e4ea0a7ae3880e6cee39f-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:25:19Z","url":{"current":"giuliana-grossi","_type":"slug"}}],"body":[{"alignment":"right","disableTextWrap":false,"widthP":38,"asset":{"_ref":"image-e8b89f6523b42f0e4eac2c396f686ac915160fbf-1200x738-jpg","_type":"reference"},"disableLightBox":true,"_type":"figure","imgcaption":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Despite challenges such as high attrition rates and adverse events, the trial highlights the value of established therapies in improving outcomes, particularly in regions with limited access to CAR T cells and bispecific antibodies.","_key":"b98fd35446b60"}],"_type":"block","style":"normal","_key":"26d8d10e54cf"},{"style":"normal","_key":"80852468cafa","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Image Credit: Egor - stock.adobe.com","_key":"29fae2e2bf54"}],"_type":"block"}],"alt":"Clinical trial results-Egor-stock.adobe.com.jpeg","_key":"1315823aabb7"},{"_type":"block","style":"normal","_key":"0eae6648feae","markDefs":[{"href":"https://www.ajmc.com/compendium/rareblood","_key":"ca7ebc86fbb9","nofollow":false,"blank":true,"_type":"link"}],"children":[{"text":"A new analysis from the phase 3 ACCoRD trial (NCT01564537) offers compelling evidence that consolidation and maintenance therapy using ixazomib (Ninlaro; Takeda) after salvage autologous hematopoietic stem cell transplantation (HSCT) significantly improves progression-free survival (PFS) in patients with relapsed ","_key":"b8c31ba01fcd0","_type":"span","marks":[]},{"marks":["ca7ebc86fbb9"],"text":"multiple myeloma","_key":"9cc3eaaef4ed","_type":"span"},{"text":" compared with observation alone.","_key":"5ecce9f3a7f4","_type":"span","marks":[]},{"text":"1","_key":"4c9d99abbd52","_type":"span","marks":["superscript"]}]},{"children":[{"marks":[],"text":"","_key":"b0fa1e6a1de5","_type":"span"}],"_type":"block","style":"normal","_key":"2a3c257c2f03","markDefs":[]},{"_key":"b3729ed07dac","markDefs":[{"blank":true,"_type":"link","href":"https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(24)00249-7/fulltext","_key":"5f526c81c7fd","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"These findings were published recently ","_key":"79238eab5881"},{"_key":"b1e4bf6d3c4a","_type":"span","marks":["5f526c81c7fd"],"text":"in "},{"_type":"span","marks":["em","5f526c81c7fd"],"text":"The Lancet Haematology","_key":"d29aec71701b"},{"_type":"span","marks":[],"text":".","_key":"797422e8fc66"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"607508ffc996","_type":"span"}],"_type":"block","style":"normal","_key":"245748a324a2"},{"_type":"block","style":"normal","_key":"12127a2667dd","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ACCoRD trial, conducted across 79 UK hospitals, enrolled patients 18 years or older with relapsed multiple myeloma requiring treatment for first progressive disease at least 12 months after an initial autologous HSCT. Following salvage HSCT, 206 patients were randomly assigned to either consolidation with ixazomib, thalidomide, and dexamethasone (ITD), followed by maintenance with single-agent ixazomib, or observation. The study’s primary end point was PFS, with safety analyzed per protocol.","_key":"35a364d8c6150"}]},{"style":"normal","_key":"418265959b30","markDefs":[],"children":[{"marks":[],"text":"","_key":"e9929e893b1e","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Participants had a median age of 62.5 years, and 69% were men. Most (61%) had received a proteasome inhibitor as part of their initial treatment, and 8% had previously received lenalidomide maintenance. Cytogenetic results revealed that 64% of participants were standard risk; 27%, high risk; and 9%, ultra–high risk.","_key":"de39904878f90"}],"_type":"block","style":"normal","_key":"e0e3bb97350e"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"84a017f95928","_type":"span"}],"_type":"block","style":"normal","_key":"6cca3c85089d"},{"style":"h3","_key":"997d2feac6af","markDefs":[],"children":[{"marks":["strong"],"text":"ACCoRD Key Findings","_key":"97a87ee993b8","_type":"span"}],"_type":"block"},{"style":"normal","_key":"9d5bc3c12d76","markDefs":[],"children":[{"text":"At a median follow-up of 27 months, the results demonstrated a clear benefit for consolidation and maintenance therapy:","_key":"38870e085fdd0","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"67ae316c25d1","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"PFS:","_key":"9d3204b83ede0"},{"_type":"span","marks":[],"text":" The median PFS was 20 months in the consolidation and maintenance group vs 13 months in the observation group (HR, 0.55; 95% CI, 0.39-0.78; ","_key":"9d3204b83ede1"},{"_type":"span","marks":["em"],"text":"P","_key":"f716370b8fde"},{"_type":"span","marks":[],"text":" = .0006).","_key":"8106492db822"}],"level":1},{"listItem":"bullet","markDefs":[],"children":[{"text":"Safety profile:","_key":"7da8ba0df4ab0","_type":"span","marks":["strong"]},{"text":" Serious adverse events were more frequent in the consolidation and maintenance groups (32%) than in the observation group (7%), with infections and upper respiratory tract infections being the most common events; no treatment-related deaths were reported","_key":"7da8ba0df4ab1","_type":"span","marks":[]}],"level":1,"_type":"block","style":"normal","_key":"e3e45a650f49"},{"_type":"block","style":"normal","_key":"32a1d76b46a4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"828a982616a4"}]},{"style":"normal","_key":"9c9807b3cd26","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The results underscore the efficacy of ixazomib-based therapy in prolonging disease control without compromising subsequent treatment options or overall survival, pending longer-term follow-up.","_key":"c22bfa2577d60"}],"_type":"block"},{"_type":"block","style":"normal","_key":"c961559f5b17","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2d8188743d29"}]},{"_type":"block","style":"normal","_key":"decd9636cfc8","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The trial’s results align with prior studies in the frontline setting, which have shown the benefits of maintenance therapy. Notably, the ACCoRD trial provides the first robust evidence for this strategy after salvage HSCT in relapsed multiple myeloma. Unlike the GMMG ReLApsE study, which found no PFS benefit for lenalidomide-based maintenance after salvage HSCT, ACCoRD participants experienced superior PFS with ixazomib, potentially due to differences in patient populations and study design.","_key":"b2d7cc52cdea0"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"922fa3fcce8c","_type":"span"}],"_type":"block","style":"normal","_key":"972d88be1287"},{"_type":"block","style":"h3","_key":"de12777f6afc","markDefs":[],"children":[{"text":"Clinical Implications","_key":"425b0e506cf10","_type":"span","marks":["strong"]}]},{"_key":"73a6da86f903","markDefs":[],"children":[{"text":"The findings support the role of salvage HSCT followed by consolidation and maintenance therapy as a viable approach in the modern treatment landscape for relapsed multiple myeloma. Ixazomib’s oral administration offers a practical and tolerable option for long-term management, avoiding the challenges associated with multiagent regimens and corticosteroid-related toxicity.","_key":"5602612a1bef0","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"style":"normal","_key":"08b9fc861307","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c8d864a89590"}],"_type":"block"},{"_key":"684bc0c1afa7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, the rapidly evolving therapeutic landscape, including the introduction of novel immunotherapies, may influence the selection of agents for posttransplant maintenance in the future. Additionally, the study raises critical questions about identifying patients who are most likely to benefit based on factors such as cytogenetic risk and response to prior treatments.","_key":"bc9286c52a850"}],"_type":"block","style":"normal"},{"_key":"9813505df399","markDefs":[],"children":[{"marks":[],"text":"","_key":"aae3612bb1ec","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"According to previous research published ","_key":"fbad8cd651e40"},{"text":"in ","_key":"7f22bbae54d4","_type":"span","marks":["5b1a8c67e904"]},{"_type":"span","marks":["em","5b1a8c67e904"],"text":"The Lancet Haemotology","_key":"c13063995d6e"},{"_type":"span","marks":[],"text":", despite challenges such as high attrition rates and adverse events like peripheral neuropathy and infections, the trial findings highlight the value of established therapies in improving outcomes, particularly in regions with limited access to modern immunotherapies like CAR T cells and bispecific antibodies.","_key":"9333d4ed6269"},{"_type":"span","marks":["superscript"],"text":"2","_key":"f22cb299b36c"},{"_type":"span","marks":[],"text":" The author noted that these findings reinforce the importance of continued therapy with widely available agents after HSCT, underscoring their role in prolonging disease control in relapsed multiple myeloma.","_key":"ba3ab558282b"}],"_type":"block","style":"normal","_key":"c926f6b885f2","markDefs":[{"href":"https://pubmed.ncbi.nlm.nih.gov/39250927/","_key":"5b1a8c67e904","nofollow":true,"blank":true,"_type":"link"}]},{"style":"normal","_key":"28a2c2090604","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7f47a90bdfef"}],"_type":"block"},{"children":[{"_type":"span","marks":["strong"],"text":"Future Directions","_key":"5f0635e478400"}],"_type":"block","style":"h3","_key":"cbc5d5667b4e","markDefs":[]},{"_type":"block","style":"normal","_key":"15799c28456c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Long-term follow-up of the ACCoRD trial will be essential to evaluate overall survival, second PFS, and the impact of consolidation and maintenance therapy on health-related quality of life.","_key":"650fc06dc4060"},{"marks":["superscript"],"text":"1","_key":"4d1267f98d9b","_type":"span"},{"_type":"span","marks":[],"text":" These data will help refine maintenance strategies and ensure that treatment is tailored to individual patient profiles.","_key":"659374ced66a"}]},{"_key":"4f000bf0672c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d18d69314a03"}],"_type":"block","style":"normal"},{"style":"normal","_key":"1c5d55c41b92","markDefs":[],"children":[{"text":"The ACCoRD trial established consolidation and maintenance with ixazomib as a superior strategy to observation after salvage HSCT for relapsed multiple myeloma, the study stated. As the therapeutic landscape continues to evolve, these findings provide a crucial benchmark for integrating maintenance therapy into routine clinical practice.","_key":"fd1dec991f770","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"ddf8e40c9af9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"90409cedecff"}],"_type":"block"},{"children":[{"_key":"2ee7639584a3","_type":"span","marks":["strong"],"text":"References"}],"_type":"block","style":"normal","_key":"d7e37734c145","markDefs":[]},{"markDefs":[],"children":[{"text":"1. Cook G, Ashcroft AJ, Senior E, et al. Ixazomib as consolidation and maintenance versus observation in patients with relapsed multiple myeloma eligible for salvage autologous stem-cell transplantation (Myeloma XII [ACCoRD]): interim analysis of a multicentre, open-label, randomised, phase 3 trial.","_key":"5454153d78e40","_type":"span","marks":[]},{"_key":"5454153d78e41","_type":"span","marks":["em"],"text":" Lancet Haematol"},{"_key":"5454153d78e42","_type":"span","marks":[],"text":". 2024;11(11):e816-e829. doi:10.1016/S2352-3026(24)00249-7"}],"_type":"block","style":"normal","_key":"b597e01cf9b6"},{"markDefs":[],"children":[{"_key":"d5830225d989","_type":"span","marks":[],"text":"2. Mai EK. Continued need for autologous transplantation in relapsed myeloma. "},{"_type":"span","marks":["em"],"text":" Lancet Haematol","_key":"01ec2440233b"},{"_type":"span","marks":[],"text":". 2024;11(11):e804-e805. doi:10.1016/S2352-3026(24)00277-1\n","_key":"1bae7b0be93b"}],"_type":"block","style":"normal","_key":"b56ad86b87ea"}],"url":"progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib","taxonomyMapping":[{"pixelTrackingCode":null,"_updatedAt":"2022-01-19T10:20:16Z","_rev":"OU32WOWh4YetHW0RkWbkso","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","parent":null,"identifier":"news","_createdAt":"2020-03-30T18:05:45Z","_type":"taxonomy","name":"News"},{"parent":{"_type":"taxonomy","name":"Compendium","_updatedAt":"2024-04-09T09:14:18Z","identifier":"compendium","_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","isMainTopic":true,"_createdAt":"2020-03-30T18:16:46Z","_rev":"oruil6rlosjyltJbhrNMGF","parent":null},"_rev":"IMgnVSbg9NVYxCJ63tKkbx","_type":"taxonomy","_id":"f20d3497-caa2-4314-9434-77f9c6be5bf6","pixelTrackingCode":null,"_createdAt":"2022-05-02T13:34:30Z","name":"Rare Blood","_updatedAt":"2022-05-02T13:34:45Z","identifier":"rareblood"},{"_id":"topic_clinical","identifier":"clinical","_rev":"HexDiduX8d6Nqnq1ECriVF","_updatedAt":"2022-02-18T12:13:55Z","summary":[{"_type":"block","style":"normal","_key":"dd8ad578cd0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e80c79954e08"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"a8e0f75c5d05"},{"marks":["superscript"],"text":"®","_key":"f7d4dddf7edd","_type":"span"},{"marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"cc409f2da7da"},{"marks":["superscript"],"text":"®","_key":"2babb3e59bb3","_type":"span"},{"marks":[],"text":" and ","_key":"d86a5bb12052","_type":"span"},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"_type":"span","marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.","_key":"b59bef533cdf"}]}],"name":"Clinical","_type":"taxonomy","_createdAt":"2020-05-04T23:46:13Z","pixelTrackingCode":null,"parent":{"parent":null,"isMainTopic":true,"_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","identifier":"topic","_createdAt":"2020-03-31T14:24:50Z","_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic"}},{"_type":"taxonomy","name":"Hematology","_id":"compendium_hematology","parent":{"_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","identifier":"compendium","isMainTopic":true,"_createdAt":"2020-03-30T18:16:46Z","_rev":"oruil6rlosjyltJbhrNMGF","parent":null,"_type":"taxonomy","name":"Compendium","_updatedAt":"2024-04-09T09:14:18Z"},"_createdAt":"2020-04-14T15:02:13Z","_rev":"GeM6ny2T6Y1Qp0cm9jBxeg","_updatedAt":"2020-07-30T14:48:10Z","identifier":"hematology","pixelTrackingCode":null}],"factCheckAuthors":null,"documentGroupMapping":null,"_type":"article","summary":"Despite challenges such as high attrition rates and adverse events, the trial highlights the value of established therapies in improving outcomes, particularly in regions with limited access to chimeric antigen receptor T cells and bispecific antibodies.","thumbnail":{"_type":"mainImage","alt":"Clinical trial results-Egor-stock.adobe.com.jpeg","asset":{"_ref":"image-e8b89f6523b42f0e4eac2c396f686ac915160fbf-1200x738-jpg","_type":"reference"}},"published":"2024-11-26T14:03:31.215Z","title":"Progression-Free Survival in Relapsed Multiple Myeloma Extended With Ixazomib, Data Show","_updatedAt":"2024-11-26T14:03:35Z","is_visible":true,"ExcludeFromPubMedXML":false,"_createdAt":"2024-11-25T20:13:53Z","_id":"def79faf-0779-4c6f-8428-44c43fe0536f","documentGroup":null,"targeting":{"content_placement":["news","compendium/rareblood","topic/clinical","compendium/hematology"],"document_url":["progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"thumbnail":{"alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"},"_type":"mainImage"},"published":"2024-11-27T17:30:00.000Z"},{"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","url":{"current":"decoding-sma-progression-hfmse-analysis-spotlights-variability","_type":"slug"},"thumbnail":{"caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"},"_type":"mainImage","alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com"},"published":"2024-11-27T17:11:13.855Z"},{"title":"2025 GOLD Report: New Insights on COPD Risks, Management","url":{"current":"2025-gold-report-new-insights-on-copd-risks-management","_type":"slug"},"thumbnail":{"alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com","asset":{"_type":"reference","_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg"},"_type":"mainImage"},"published":"2024-11-27T17:00:00.000Z"},{"title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","url":{"current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"}},"published":"2024-11-27T16:36:49.639Z"},{"title":"Trump Taps Bhattacharya to Lead National Institutes of Health","url":{"current":"trump-taps-bhattacharya-to-lead-national-institutes-of-health","_type":"slug"},"thumbnail":{"asset":{"_ref":"image-7ac1cde025aed75c9e104813e932522251aca3ea-4576x3051-jpg","_type":"reference"},"_type":"mainImage","alt":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","caption":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com"},"published":"2024-11-27T15:40:01.812Z"},{"title":"Navigating Healthcare Access and Decision-Making","url":{"current":"navigating-healthcare-access-and-decision-making","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"published":"2024-11-27T14:12:30.463Z"}]},{"summary":"If approved, the combination regimen would be the first FDA-approved treatment for adults with recurrent KRAS mutant low-grade serous ovarian cancer (LGSOC).","canonicalUrl":"https://www.pharmacytimes.com/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application","_createdAt":"2024-11-25T23:53:21Z","documentGroupMapping":null,"is_visible":true,"_updatedAt":"2024-11-26T00:44:08Z","authorMapping":[{"_id":"8d1b4544-16b0-40e2-ac85-9f78ff3f4d8a","_updatedAt":"2023-11-03T17:54:46Z","url":{"current":"gillian-mcgovern","_type":"slug"},"displayName":"Gillian McGovern","_createdAt":"2023-11-03T17:54:46Z","_rev":"lr42ZkL95YwmOo7eXMiC9a","_type":"author"}],"contentCategory":{"_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh"},"title":"Avutometinib With Defactinib for Recurrent KRAS Mutant LGSOC Completes Rolling New Drug Application","_id":"702a31e1-a348-48b5-bbfe-686408dbb5be","authors":[{"displayName":"Gillian McGovern","url":"gillian-mcgovern"}],"factCheckAuthors":null,"seoTag":["ovarian cancer","new drug application","FDA","avutometinib with defactinib","low-grade serous ovarian cancer","LGSOC"],"factCheckAuthorMapping":null,"documentGroup":null,"_type":"article","body":[{"children":[{"_type":"span","marks":["em"],"text":"This article was originally published on ","_key":"7eb8ac5c6455"},{"_type":"span","marks":["em","243c3364e863"],"text":"Pharmacy Times","_key":"75873b99b0ba"},{"marks":["superscript","em","243c3364e863"],"text":"®","_key":"f27c7972f01f","_type":"span"},{"_type":"span","marks":["superscript","em"],"text":" ","_key":"ca30e12bedf7"},{"marks":["em"],"text":"and has been lightly edited.","_key":"636321527d0d","_type":"span"}],"_type":"block","style":"normal","_key":"802d7340b868","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.pharmacytimes.com/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application","_key":"243c3364e863"}]},{"_key":"ff0bfcfefd47","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"cb93645dd654"}],"_type":"block","style":"normal"},{"_key":"90209f1b3a88","markDefs":[{"_type":"link","href":"https://www.businesswire.com/news/home/20241031747822/en/Verastem-Oncology-Completes-Rolling-NDA-Submission-to-the-FDA-for-Avutometinib-Plus-Defactinib-as-a-Treatment-for-Recurrent-KRAS-Mutant-Low-Grade-Serous-Ovarian-Cancer","_key":"1431c1a0c45e","nofollow":true,"blank":true},{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/ovarian-cancer","_key":"f7ff606b4557","nofollow":false}],"children":[{"text":"The rolling new drug application (NDA) for the investigational combination of avutometinib (VS-6766; Verastem Oncology) and defactinib (VS-6063; Verastem Oncology) for adults with recurrent ","_key":"73e35493d8150","_type":"span","marks":[]},{"marks":["em"],"text":"KRAS","_key":"9e348f0d429a","_type":"span"},{"_key":"675c51a9f97f","_type":"span","marks":[],"text":" mutant l"},{"_type":"span","marks":["f7ff606b4557"],"text":"ow-grade serous ovarian cancer (LGSOC)","_key":"ea9b429c0da1"},{"_type":"span","marks":[],"text":" who received at least 1 prior systemic therapy has been completed, according to a ","_key":"db092e65f327"},{"_type":"span","marks":["1431c1a0c45e"],"text":"press release","_key":"db737d980b6c"},{"_type":"span","marks":[],"text":".","_key":"5edaddda261b"},{"_type":"span","marks":["superscript"],"text":"1 ","_key":"b972843f64eb"}],"_type":"block","style":"normal"},{"_key":"71f4600334d1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e4600a8ca83b"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"The NDA was submitted under the FDA’s accelerated approval pathway. If granted, the review will be completed within 6 months following the 60-day filing period.","_key":"9d052751703e","_type":"span"}],"_type":"block","style":"normal","_key":"48f548c575f0"},{"_type":"block","style":"normal","_key":"ade9fc61c9a1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9159a81b4dbc0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Avutometinib is an oral RAF/MEK clamp that induces complexes of MEK with ARAF, BRAF, and CRAF, potentially creating a more complete and durable anti-tumor response through maximal RAS/MAPK pathway inhibition. Unlike MEK-only inhibitors, it blocks both MEK kinase activity and the ability of RAF to phosphorylate MEK. ","_key":"1590ba492d8b0"}],"_type":"block","style":"normal","_key":"d8b88a12138f"},{"_type":"block","style":"normal","_key":"b1d54c7df0f9","markDefs":[],"children":[{"text":"","_key":"e07170d78bd5","_type":"span","marks":[]}]},{"markDefs":[{"_type":"link","href":"https://www.pharmacytimes.com/view/fda-grants-orphan-drug-designation-for-avutometinib-alone-or-with-defactinib-in-recurrent-lgsoc","_key":"c6351ebf7d80","nofollow":true,"blank":true}],"children":[{"_key":"4549f4f9fa76","_type":"span","marks":[],"text":"Defactinib is an oral selective FAK inhibitor. The combination treatment was previously "},{"_type":"span","marks":["c6351ebf7d80"],"text":"granted","_key":"eb019acf8177"},{"marks":[],"text":" an orphan drug designation for treating patients with LGSOC regardless of their ","_key":"6c6617a74b2d","_type":"span"},{"_type":"span","marks":["em"],"text":"KRAS","_key":"2a299eeef2dd"},{"_type":"span","marks":[],"text":" status following 1 or more prior lines of therapy, including platinum-based chemotherapies.","_key":"8c5e0f6120d4"},{"_type":"span","marks":["superscript"],"text":"2","_key":"b30011b75b00"}],"_type":"block","style":"normal","_key":"e7f57cdfcced"},{"widthP":40,"alt":"FDA headquarters | Image Credit: Tada Images - stock.adobe.com","imgcaption":[{"markDefs":[],"children":[{"marks":[],"text":"If approved, the combination regimen would be the first FDA-approved treatment for adults with recurrent KRAS mutant low-grade serous ovarian cancer (LGSOC). | Image Credit: Grandbrothers - stock.adobe.com","_key":"076ccfb24396","_type":"span"}],"_type":"block","style":"normal","_key":"c19cf2a429a2"}],"asset":{"_ref":"image-27d488950c5a56c184f46ca9ccce51baadec1a29-5607x3738-jpg","_type":"reference"},"_type":"figure","_key":"60f831c087d2","disableTextWrap":false,"alignment":"right","disableLightBox":true},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"LGSOC is a rare ovarian cancer that is persistent and ultimately fatal.","_key":"d447593a9ac70"},{"marks":["superscript"],"text":"1","_key":"9402d990c46d","_type":"span"},{"_type":"span","marks":[],"text":" It is distinct and different from high-grade serous ovarian cancer and requires different treatments. The disease is highly recurrent and less sensitive to chemotherapy, and it tends to affect younger women who have bimodal peaks of diagnosis between ages 20 to 30 and 50 to 60, with a median overall survival (OS) of about 10 years. The current standard of care includes hormone therapy and chemotherapy, but there are no FDA-approved treatments specifically for LGSOC.","_key":"9c7bfb91c098"}],"_type":"block","style":"normal","_key":"21c0a4dbe58e"},{"_key":"4582336ef659","markDefs":[],"children":[{"_key":"7d93712e06ef","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"style":"normal","_key":"5304b3ec4007","markDefs":[],"children":[{"_key":"c79224f9536b0","_type":"span","marks":[],"text":"The NDA submissions were initiated following the review of preliminary data and supportive data from the FRAME phase 1 trial. Updated results from the phase 2 RAMP 201 study (NCT04625270) were presented at a late-breaking oral plenary presentation at the International Gynecologic Cancer Society (IGCS) 2024 Annual Meeting, which was held in Dublin, Ireland from October 16 to 18."}],"_type":"block"},{"style":"normal","_key":"5d0e5819274e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8d62e95806eb1"}],"_type":"block"},{"style":"normal","_key":"0344a8802d5c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"RAMP 201 is an adaptive, 2-part multicenter, randomized, open-label phase 2 study (NCT04625270) to evaluate the efficacy and safety of avutometinib alone and in combination with defactinib in patients with recurrent LGSOC with or without a ","_key":"7614889f3cfe0"},{"_type":"span","marks":["em"],"text":"KRAF","_key":"b0a031a830ae"},{"_type":"span","marks":[],"text":" mutation. In part A of the study, the selection of patients was determined and administered with a “go forward” treatment regimen, which included the combination of avutometinib and defactinib compared with avutometinib alone, based on overall response rates (ORR). ","_key":"683f1623fd21"}],"_type":"block"},{"_key":"e2f133a54a7b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"31145b84b538"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"The expansion phases of the trial—parts B and C—evaluate the safety and efficacy of the go forward regimen (3.2 mg of avutometinib twice per week and 200 mg of defactinib twice per week). Additionally, part D ","_key":"2f7be48b34cb"},{"marks":["bd52008c01cc"],"text":"evaluates","_key":"51d745fad22e","_type":"span"},{"text":" a low dose of avutometinib in combination with defactinib to inform individualized dose reduction.","_key":"a48ee8b4954a","_type":"span","marks":[]},{"_key":"9d04a5a9e1c8","_type":"span","marks":["superscript"],"text":"3"}],"_type":"block","style":"normal","_key":"75af04d85264","markDefs":[{"_key":"bd52008c01cc","nofollow":true,"blank":true,"_type":"link","href":"https://clinicaltrials.gov/study/NCT04625270"}]},{"style":"normal","_key":"881b309379e3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"50ae0d7a0d6b"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"The primary endpoint for all parts of the study is ORR, measured from the start of treatment to confirmation of response, or 24 weeks. Secondary endpoints include complete response, duration of response, disease control rate (DCR), progression-free survival (PFS), and OS.","_key":"672feb1a38bc0"}],"_type":"block","style":"normal","_key":"a26d5d76e8ab","markDefs":[]},{"_key":"c198f2c3af8a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"17951cb8b13d"}],"_type":"block","style":"normal"},{"children":[{"_key":"0a271bf687f60","_type":"span","marks":[],"text":"According to the findings presented at the IGCS plenary session, patients with "},{"_type":"span","marks":["em"],"text":"KRAS","_key":"6495b1e92694"},{"_type":"span","marks":[],"text":" mutant LGSOC had a confirmed ORR of about 44%, a median PFS of 22 months, and a DCR of 70% at the 6-month point. In addition, the updated data continue to show that avutometinib combined with defactinib is generally well-tolerated, with a 10% discontinuation rate because of adverse events across all patients, both ","_key":"db96aeb1035a"},{"_type":"span","marks":["em"],"text":"KRAS","_key":"3be69d1b0db7"},{"_type":"span","marks":[],"text":" mutant and ","_key":"45671bb3027f"},{"_type":"span","marks":["em"],"text":"KRAS","_key":"ed1cb15d256b"},{"_type":"span","marks":[],"text":" wild-type.","_key":"06b3f9760f21"},{"_type":"span","marks":["superscript"],"text":"1,3","_key":"5065b06e341e"}],"_type":"block","style":"normal","_key":"8c08ad028123","markDefs":[]},{"style":"normal","_key":"26f4e3b2945f","markDefs":[],"children":[{"text":"","_key":"ed2e41cb4f89","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"text":"Enrollment is ongoing for RAMP 301, an international phase 3 trial that will include patients with recurrent LGSOC regardless of ","_key":"514744eb94740","_type":"span","marks":[]},{"text":"KRAS","_key":"cda41130635f","_type":"span","marks":["em"]},{"_key":"94f33f088254","_type":"span","marks":[],"text":" mutation status. The trial will serve as a confirmatory study for the initial indication and has the potential to support an expanded indication, regardless of "},{"_key":"a14e11574fbf","_type":"span","marks":["em"],"text":"KRAS"},{"_key":"917531b34c16","_type":"span","marks":[],"text":" mutation status."},{"_type":"span","marks":["superscript"],"text":"1","_key":"a986ec4e984a"}],"_type":"block","style":"normal","_key":"052f23e94800"},{"_type":"block","style":"normal","_key":"19573418643a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"91d535131989"}]},{"children":[{"_key":"118c8da770b20","_type":"span","marks":[],"text":"“We believe that avutometinib in combination with defactinib has the potential to change the treatment paradigm for patients with recurrent "},{"_type":"span","marks":["em"],"text":"KRAS","_key":"fdd155d088a9"},{"_type":"span","marks":[],"text":" mutant LGSOC,” Dan Paterson, president and CEO of Verastem Oncology, said in a news release. “Completing our NDA submission is a significant milestone…we plan for potential FDA approval in mid-2025, but also for patients as there are no FDA-approved treatments specifically for this rare ovarian cancer.”","_key":"4bc244b22d1f"}],"_type":"block","style":"normal","_key":"7bf952a82ad9","markDefs":[]},{"style":"normal","_key":"8c56a5799487","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8d6cac440a310"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"ed6873e36ced0"}],"_type":"block","style":"normal","_key":"0e187a92e168"},{"children":[{"marks":[],"text":"Businesswire. Verastem Oncology completes rolling NDA submission to the FDA for avutometinib plus defactinib as a treatment for recurrent ","_key":"5bb60f91d85c0","_type":"span"},{"marks":["em"],"text":"KRAS","_key":"fdd11a435a92","_type":"span"},{"text":" mutant low-grade serous ovarian cancer. News release. October 31, 2024. Accessed November 25, 2024. ","_key":"4831daf79751","_type":"span","marks":[]},{"_type":"span","marks":["d3c262f625df"],"text":"https://www.businesswire.com/news/home/20241031747822/en/Verastem-Oncology-Completes-Rolling-NDA-Submission-to-the-FDA-for-Avutometinib-Plus-Defactinib-as-a-Treatment-for-Recurrent-KRAS-Mutant-Low-Grade-Serous-Ovarian-Cancer","_key":"5bb60f91d85c1"}],"level":1,"_type":"block","style":"normal","_key":"cce7b448c470","listItem":"number","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.businesswire.com/news/home/20241031747822/en/Verastem-Oncology-Completes-Rolling-NDA-Submission-to-the-FDA-for-Avutometinib-Plus-Defactinib-as-a-Treatment-for-Recurrent-KRAS-Mutant-Low-Grade-Serous-Ovarian-Cancer","_key":"d3c262f625df"}]},{"_type":"block","style":"normal","_key":"abb3da3727c8","listItem":"number","markDefs":[{"blank":true,"_type":"link","href":"https://www.pharmacytimes.com/view/fda-grants-orphan-drug-designation-for-avutometinib-alone-or-with-defactinib-in-recurrent-lgsoc","_key":"4d2e4720daba","nofollow":true}],"children":[{"text":"McGovern, G. FDA grants orphan drug designation for avutometinib alone or with defactinib in recurrent LGSOC. Pharmacy Times. March 7, 2024. Accessed November 25, 2024. ","_key":"a59fd2fead590","_type":"span","marks":[]},{"_key":"a59fd2fead593","_type":"span","marks":["4d2e4720daba"],"text":"https://www.pharmacytimes.com/view/fda-grants-orphan-drug-designation-for-avutometinib-alone-or-with-defactinib-in-recurrent-lgsoc"}],"level":1},{"_key":"088e3e8327d2","listItem":"number","markDefs":[{"blank":true,"_type":"link","href":"https://clinicaltrials.gov/study/NCT04625270","_key":"3620a6c4737f","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"A study of avutometinib (VS-6766) v. avutometinib (VS-6766) + defactinib in recurrent low-grade serous ovarian cancer with and without a ","_key":"a3d117591c570"},{"_type":"span","marks":["em"],"text":"KRAS","_key":"2687778ba4b4"},{"text":" mutation (RAMP 201). ClinicalTrials.gov. Updated March 12, 2024. Accessed November 25, 2024. ","_key":"be846bedb972","_type":"span","marks":[]},{"_type":"span","marks":["3620a6c4737f"],"text":"https://clinicaltrials.gov/study/NCT04625270","_key":"a3d117591c571"}],"level":1,"_type":"block","style":"normal"}],"ExcludeFromPubMedXML":false,"articleType":"News","url":"avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application","taxonomyMapping":[{"name":"News","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z","identifier":"news","_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","parent":null,"pixelTrackingCode":null,"_createdAt":"2020-03-30T18:05:45Z"},{"_type":"taxonomy","_id":"topic_clinical","_createdAt":"2020-05-04T23:46:13Z","_rev":"HexDiduX8d6Nqnq1ECriVF","_updatedAt":"2022-02-18T12:13:55Z","pixelTrackingCode":null,"parent":{"_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","_updatedAt":"2021-10-21T10:15:35Z","_createdAt":"2020-03-31T14:24:50Z","_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","identifier":"topic","isMainTopic":true,"parent":null},"name":"Clinical","identifier":"clinical","summary":[{"_type":"block","style":"normal","_key":"dd8ad578cd0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e80c79954e08"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"a8e0f75c5d05"},{"marks":["superscript"],"text":"®","_key":"f7d4dddf7edd","_type":"span"},{"marks":[],"text":" clinical page includes all the published content across AJMC.com, ","_key":"0f03d46e3b3a","_type":"span"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"cc409f2da7da"},{"marks":["superscript"],"text":"®","_key":"2babb3e59bb3","_type":"span"},{"marks":[],"text":" and ","_key":"d86a5bb12052","_type":"span"},{"_type":"span","marks":["em"],"text":"Evidence-Based Oncology","_key":"40b2eaba6c17"},{"_type":"span","marks":[],"text":"™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.","_key":"b59bef533cdf"}]}]},{"_id":"5d36a016-ab62-449e-9bd0-f0dd367b5317","video":{"isTaxVideo":false},"_updatedAt":"2024-06-10T20:21:44Z","videoPlayerConfig":{"brightcoveAccountID":"5436121609001"},"pixelTrackingCode":null,"_rev":"N7mKycgLbGtEq6btkEC3jJ","_type":"taxonomy","taxonomyArchived":false,"_createdAt":"2024-06-10T20:21:44Z","name":"Canonical","usedForRecommendations":false,"parent":null},{"name":"Ovarian Cancer","identifier":"ovarian-cancer","perKeywordMapping":["Gynecologic Cancer","Health Equity Diversity \u0026 Inclusion"],"pixelTrackingCode":null,"_id":"6a2edd2a-0a01-4a76-a275-5e9152ffa52c","parent":{"name":"Compendium","_updatedAt":"2024-04-09T09:14:18Z","isMainTopic":true,"_createdAt":"2020-03-30T18:16:46Z","_type":"taxonomy","parent":null,"identifier":"compendium","_rev":"oruil6rlosjyltJbhrNMGF","_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a"},"cmeType":"per","_createdAt":"2020-11-06T18:46:32Z","_rev":"lr42ZkL95YwmOo7eXMlKXl","_type":"taxonomy","_updatedAt":"2023-11-03T18:14:23Z"}],"published":"2024-11-26T14:00:00.000Z","_rev":"mXf4W004dWP7HhMB6qSI2U","thumbnail":{"asset":{"_ref":"image-27d488950c5a56c184f46ca9ccce51baadec1a29-5607x3738-jpg","_type":"reference"},"_type":"mainImage","alt":"FDA headquarters | Image Credit: Grandbrothers - stock.adobe.com"},"targeting":{"content_placement":["news","topic/clinical","compendium/ovarian-cancer"],"document_url":["avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF","url":{"current":"facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"}},"published":"2024-11-27T17:30:00.000Z"},{"title":"Decoding SMA Progression: HFMSE Analysis Spotlights Variability","url":{"current":"decoding-sma-progression-hfmse-analysis-spotlights-variability","_type":"slug"},"thumbnail":{"alt":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","caption":"Keeping track of subgroup variability in SMA will provide more robust, comparable data in the long term | image credit: Bartek - stock.adobe.com","asset":{"_ref":"image-16ff03fc3732bb1b18d238c8f8af52fac1f6476e-5696x3392-jpg","_type":"reference"},"_type":"mainImage"},"published":"2024-11-27T17:11:13.855Z"},{"title":"2025 GOLD Report: New Insights on COPD Risks, Management","url":{"current":"2025-gold-report-new-insights-on-copd-risks-management","_type":"slug"},"thumbnail":{"alt":"COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com","asset":{"_ref":"image-6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900-jpg","_type":"reference"},"_type":"mainImage"},"published":"2024-11-27T17:00:00.000Z"},{"title":"Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies","url":{"_type":"slug","current":"durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies"},"thumbnail":{"alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"},"_type":"mainImage"},"published":"2024-11-27T16:36:49.639Z"},{"title":"Trump Taps Bhattacharya to Lead National Institutes of Health","url":{"current":"trump-taps-bhattacharya-to-lead-national-institutes-of-health","_type":"slug"},"thumbnail":{"caption":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com","asset":{"_ref":"image-7ac1cde025aed75c9e104813e932522251aca3ea-4576x3051-jpg","_type":"reference"},"_type":"mainImage","alt":"National Institutes of Health | Image credit: Grandbrothers - stock.adobe.com"},"published":"2024-11-27T15:40:01.812Z"},{"title":"Navigating Healthcare Access and Decision-Making","url":{"current":"navigating-healthcare-access-and-decision-making","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"published":"2024-11-27T14:12:30.463Z"}]}],"relatedVideos":[{"published":"2024-11-27T14:12:30.463Z","_id":"6536a2f4-e831-4b84-a8cc-d60b4651f3ca","summary":"An analysis of challenges and strategies for integrating HER2-directed therapies into decision-making for NSCLC, with a focus on timely updates, collaborative efforts among stakeholders, and balancing equitable access with cost management.","authorMapping":null,"authors":null,"factCheckAuthorMapping":null,"url":"navigating-healthcare-access-and-decision-making","title":"Navigating Healthcare Access and Decision-Making","thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"contentCategory":{"_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z"},"factCheckAuthors":null},{"published":"2024-11-27T14:05:56.427Z","summary":"An overview of challenges in transitioning from IV to oral medications and guidance on identifying NSCLC patient populations most likely to benefit from HER2-directed therapies through informed patient selection strategies.","thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"authors":null,"factCheckAuthors":null,"_id":"0333be78-ba62-42fd-9255-7ace0ab55c9d","title":"Patient Selection and Personalized Treatment Strategies","contentCategory":{"_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z"},"authorMapping":null,"factCheckAuthorMapping":null,"url":"patient-selection-and-personalized-treatment-strategies"},{"factCheckAuthorMapping":null,"thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"contentCategory":{"_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76"},"authorMapping":null,"authors":null,"published":"2024-11-27T14:00:19.983Z","_id":"8834a537-17ed-4106-acfb-6f3268407649","title":"Emerging Horizons in HER2-Directed NSCLC Treatments","summary":"A review of recent clinical trial results for emerging HER2-directed therapies, including SOHO-01, inetetamab/pyrotinib, and BEAMION Lung-01, and their potential impact on the future treatment landscape for HER2-positive NSCLC.","factCheckAuthors":null,"url":"emerging-horizons-in-her2-directed-nsclc-treatments"},{"authors":null,"factCheckAuthors":null,"published":"2024-11-27T13:57:44.218Z","title":"Managing Treatment Challenges in HER2-Directed Therapies","summary":"An exploration of emerging strategies to overcome resistance to HER2-directed therapies based on ongoing research advancements.","authorMapping":null,"url":"managing-treatment-challenges-in-her2-directed-therapies","_id":"ea2127f5-645f-45ff-8ac0-e846c0ee5952","thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_type":"reference","_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png"}},"contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"factCheckAuthorMapping":null},{"published":"2024-11-27T13:46:50.689Z","title":"Real-World Outcomes in HER2-Positive NSCLC","summary":"Dr Heymach real-world outcomes versus clinical trials for HER2-positive NSCLC and the management of common adverse events associated with HER2-directed therapies.","thumbnail":{"_type":"mainImage","alt":"4 KOLs are featured in this series","asset":{"_ref":"image-bae96e4a31573dfc8f43691290303d02008b15c4-1335x712-png","_type":"reference"}},"authors":null,"url":"real-world-outcomes-in-her2-positive-nsclc","_id":"9cd3398d-a6d1-4b6b-b9d6-e459b84176df","contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"authorMapping":null,"factCheckAuthorMapping":null,"factCheckAuthors":null},{"authors":[{"displayName":"Paul Feuerstadt, MD, FACG, AGAF","url":"paul-feuerstadt-md-facg-agaf"}],"factCheckAuthors":null,"published":"2024-11-26T18:52:33.021Z","summary":"Paul Feuerstadt, MD, FACG, AGAF, discusses how testing for Clostridioides difficile is recommended for hospitalized patients or outpatients with new-onset, unexplained diarrhea who have risk factors such as recent antibiotic use, hospitalization, or older age, and how empiric treatment should be initiated while awaiting test results if there is high clinical suspension. ","thumbnail":{"alt":"1 expert in this video","asset":{"_ref":"image-5a87648f7abba8a971c7928bd318187bf708e246-1920x1080-png","_type":"reference"},"_type":"mainImage"},"contentCategory":{"_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76"},"url":"the-role-of-testing-for-c-difficile-in-clinical-practice","_id":"84293d62-86e4-4ab8-b272-1fd7d37858f8","title":"The Role of Testing for C Difficile in Clinical Practice","authorMapping":[{"firstName":"Paul","authorType":"expert","displayName":"Paul Feuerstadt, MD, FACG, AGAF","_id":"a214f75c-583c-4cf6-9890-8a5b23491faa","_updatedAt":"2024-11-26T18:54:44Z","url":{"current":"paul-feuerstadt-md-facg-agaf","_type":"slug"},"lastName":"Feuerstadt","_createdAt":"2024-11-26T18:54:44Z","_rev":"YGlLVDrzBhKaX9zB0Q5bsh","_type":"author"}],"factCheckAuthorMapping":null},{"contentCategory":{"_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76"},"authorMapping":[{"authorType":"expert","displayName":"Paul Feuerstadt, MD, FACG, AGAF","_id":"a214f75c-583c-4cf6-9890-8a5b23491faa","_updatedAt":"2024-11-26T18:54:44Z","url":{"current":"paul-feuerstadt-md-facg-agaf","_type":"slug"},"firstName":"Paul","_createdAt":"2024-11-26T18:54:44Z","_rev":"YGlLVDrzBhKaX9zB0Q5bsh","_type":"author","lastName":"Feuerstadt"}],"factCheckAuthorMapping":null,"published":"2024-11-26T18:52:33.021Z","title":"Utilizing Antibiotics in Treatment of C Difficile ","thumbnail":{"asset":{"_ref":"image-5a87648f7abba8a971c7928bd318187bf708e246-1920x1080-png","_type":"reference"},"_type":"mainImage","alt":"1 expert in this video"},"authors":[{"displayName":"Paul Feuerstadt, MD, FACG, AGAF","url":"paul-feuerstadt-md-facg-agaf"}],"factCheckAuthors":null,"url":"utilizing-antibiotics-in-treatment-of-c-difficile","_id":"9ec6f878-cb87-48c0-a2f2-150c92158354","summary":"The panelist discusses how antibiotics are paradoxically both the primary treatment for Clostridioides difficile infections and a major risk factor for recurrence since they disrupt the protective gut microbiome, which led to the development of alternative therapies like fecal microbiota transplantation to restore microbial balance and prevent reinfection. "},{"summary":"Amit Saxena, MD, discusses how personalized treatment decisions for lupus nephritis require careful consideration of patient characteristics, multidisciplinary coordination, and emerging guidelines, while acknowledging both the opportunities and challenges that lie ahead in clinical practice.","contentCategory":{"_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z"},"factCheckAuthors":null,"url":"looking-ahead-anticipating-changes-in-lupus-guidelines-and-clinical-practice","published":"2024-11-08T20:19:46.106Z","_id":"ec78a466-119e-41d1-b5f8-a242c80d6b13","title":"Looking Ahead: Anticipating Changes in Lupus Guidelines and Clinical Practice","factCheckAuthorMapping":null,"thumbnail":{"_type":"mainImage","alt":"1 KOL is featured in this series.","asset":{"_ref":"image-f52b9836d747de80f88cb878807eca847840e7a3-1920x1080-png","_type":"reference"}},"authorMapping":[{"authorType":"expert","_createdAt":"2024-11-08T20:07:42Z","_rev":"9zncfngkl3TWl94VhcQ0Ms","_updatedAt":"2024-11-08T20:07:42Z","firstName":"Amit","lastName":"Saxena","_id":"4919858d-1818-4dfb-a189-d1c29e919ce7","url":{"current":"amit-saxena-md","_type":"slug"},"displayName":"Amit Saxena, MD","_type":"author"}],"authors":[{"displayName":"Amit Saxena, MD","url":"amit-saxena-md"}]},{"thumbnail":{"_type":"mainImage","alt":"1 KOL is featured in this series.","asset":{"_ref":"image-f52b9836d747de80f88cb878807eca847840e7a3-1920x1080-png","_type":"reference"}},"authorMapping":[{"_type":"author","_id":"4919858d-1818-4dfb-a189-d1c29e919ce7","url":{"current":"amit-saxena-md","_type":"slug"},"displayName":"Amit Saxena, MD","lastName":"Saxena","authorType":"expert","_createdAt":"2024-11-08T20:07:42Z","_rev":"9zncfngkl3TWl94VhcQ0Ms","_updatedAt":"2024-11-08T20:07:42Z","firstName":"Amit"}],"url":"from-guidelines-to-practice-advancing-lupus-nephritis-treatment","contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"authors":[{"displayName":"Amit Saxena, MD","url":"amit-saxena-md"}],"factCheckAuthorMapping":null,"factCheckAuthors":null,"published":"2024-11-08T20:07:13.246Z","_id":"2ad7fe37-6965-49ea-8b8c-4498beb75bd2","title":"From Guidelines to Practice: Advancing Lupus Nephritis Treatment","summary":"Amit Saxena, MD, discusses how evidence-based guidelines from ACR and KDIGO have evolved to shape lupus nephritis treatment approaches, emphasizing their critical role in standardizing patient care and incorporating recent advances like new therapeutic options and refined diagnostic criteria."},{"published":"2024-11-08T13:58:21.347Z","authors":[{"displayName":"Toby Maher, MD, PhD ","url":"toby-maher-md-phd"}],"factCheckAuthors":null,"factCheckAuthorMapping":null,"url":"impact-of-treatment-delays-on-patient-outcomes","_id":"6a75aecc-e769-4ee6-9d5d-732ee411ea80","title":"Impact of Treatment Delays on Patient Outcomes","summary":"Toby Maher, MD, PhD, discusses how delays in treatment for idiopathic pulmonary fibrosis (IPF) can significantly worsen patient outcomes and accelerate disease progression, underscoring the critical need for timely intervention.","thumbnail":{"_type":"mainImage","alt":"Justin Oldham, MD, MS, an expert on IPF","asset":{"_ref":"image-81378af81ea01473112fda9db15216dd52b1a856-1920x1080-png","_type":"reference"}},"contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"authorMapping":[{"_updatedAt":"2024-10-17T16:23:50Z","url":{"current":"toby-maher-md-phd","_type":"slug"},"displayName":"Toby Maher, MD, PhD ","_createdAt":"2024-10-17T16:23:50Z","_rev":"KLVqzQL7KTVccOrMxskyx4","_type":"author","_id":"be280a40-67ac-4189-ae77-c1cd9e289d5b"}]}],"relatedTopics":[{"id":"a2b81a45-b589-4252-b45d-cf65773d1186","name":"Gene Therapy","type":"taxonomy","url":"/compendium/gene-therapy"},{"id":"topic_clinical","name":"Clinical","type":"taxonomy","url":"/topic/clinical"}],"algoliaData":{"algoliaDocGroup":[],"algoliaTax":[{"id":"a2b81a45-b589-4252-b45d-cf65773d1186","name":"Gene Therapy","type":"taxonomy","url":"/compendium/gene-therapy"},{"id":"topic_clinical","name":"Clinical","type":"taxonomy","url":"/topic/clinical"}],"excludeIDs":["9109232d-ed88-49c1-b50e-7bfa373ea3e2"],"articleCategoryID":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","podcastsCategoryID":"367becaf-13c4-4502-9c8c-939f4f480898","videoCategoryID":"ee14ccb3-3542-4414-9046-927be1198c76"}},"targeting":{"content_placement":["compendium/gene-therapy","topic/clinical","news"],"document_url":["new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma"],"document_group":[],"content_group":[],"rootDocumentGroup":[],"issue_url":[],"publication_url":[],"tags":["haploidentical HSCT ","CAR T-cell therapy ","CD7-Positive Leukemia/Lymphoma"],"hostname":"www.ajmc.com"},"mediaSeries":null,"videoData":{}},"queryString":{"slug":["view","new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma"]}},"host":"www.ajmc.com"},"__N_SSG":true},"page":"/view/[...slug]","query":{"slug":["new-strategy-shows-promise-for-cd7-positive-leukemia-lymphoma"]},"buildId":"MDzUGgoo5zJ9FwYvn4DYi","isFallback":false,"gsp":true,"appGip":true,"scriptLoader":[]}</script></body></html>