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cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Glavni meni</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Glavni meni</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">sakrij</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigacija </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Po%C4%8Detna_strana" title="Posjeti početnu stranicu [z]" accesskey="z"><span>Početna strana</span></a></li><li id="n-sidebar-featured" class="mw-list-item"><a href="/wiki/Wikipedia:Istaknuti_%C4%8Dlanci"><span>Istaknuti članci</span></a></li><li id="n-sidebar-portals" class="mw-list-item"><a href="/wiki/Wikipedia:Portal"><span>Portali</span></a></li><li id="n-sidebar-categories" class="mw-list-item"><a href="/wiki/Wikipedia:Kategorije"><span>Kategorije</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Posebno:Nedavne_izmjene" title="Spisak nedavnih izmjena na wiki. [r]" accesskey="r"><span>Nedavne izmjene</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Posebno:Nasumi%C4%8Dna_stranica" title="Učitaj nasumičnu stranicu [x]" accesskey="x"><span>Nasumična stranica</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Interakcija </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Pomo%C4%87:Sadr%C5%BEaj" title="Mjesto gdje možete nešto da naučite."><span>Pomoć</span></a></li><li id="n-sidebar-sandbox" class="mw-list-item"><a href="/wiki/Wikipedia:Igrali%C5%A1te"><span>Igralište</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Vrata_zajednice" title="O projektu, šta možete da uradite, gdje se šta nalazi"><span>Vrata zajednice</span></a></li><li id="n-sidebar-village-pump" class="mw-list-item"><a href="/wiki/Wikipedia:%C4%8Car%C5%A1ija"><span>Čaršija</span></a></li><li id="n-sidebar-news" class="mw-list-item"><a href="/wiki/Wikipedia:Novosti"><span>Novosti</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Po%C4%8Detna_strana" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="Slobodna enciklopedija" src="/static/images/mobile/copyright/wikipedia-tagline-bs.svg" width="118" height="13" style="width: 7.375em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width 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aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Izgled" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Izgled</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_bs.wikipedia.org&uselang=bs" class=""><span>Donacije</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Posebno:Napravi_ra%C4%8Dun&returnto=Policitemija+vera" title="Predlažemo vam da napravite račun i prijavite se; međutim, to nije obavezno" class=""><span>Napravi korisnički račun</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Posebno:Korisni%C4%8Dka_prijava&returnto=Policitemija+vera" title="Predlažemo vam da se prijavite, iako to nije obavezno [o]" accesskey="o" class=""><span>Prijavi me</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Više opcija" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Lični alati" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Lični alati</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Korisnički meni" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_bs.wikipedia.org&uselang=bs"><span>Donacije</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Posebno:Napravi_ra%C4%8Dun&returnto=Policitemija+vera" title="Predlažemo vam da napravite račun i prijavite se; međutim, to nije obavezno"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Napravi korisnički račun</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Posebno:Korisni%C4%8Dka_prijava&returnto=Policitemija+vera" title="Predlažemo vam da se prijavite, iako to nije obavezno [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Prijavi me</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Stranice za odjavljene urednike <a href="/wiki/Pomo%C4%87:Uvod" aria-label="Saznajte više o uređivanju"><span>detaljnije</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Posebno:Moji_doprinosi" title="Spisak izmjena napravljenih s ove IP-adrese [y]" accesskey="y"><span>Doprinosi</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Posebno:Moj_razgovor" title="Rasprava o izmjenama s ove IP-adrese [n]" accesskey="n"><span>Razgovor</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"><div 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id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Početak</div> </a> </li> <li id="toc-Znakovi_i_simptomi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Znakovi_i_simptomi"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Znakovi i simptomi</span> </div> </a> <ul id="toc-Znakovi_i_simptomi-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Patofiziologija" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Patofiziologija"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Patofiziologija</span> </div> </a> <ul id="toc-Patofiziologija-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dijagnoza" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Dijagnoza"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Dijagnoza</span> </div> </a> <ul id="toc-Dijagnoza-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liječenje" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Liječenje"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Liječenje</span> </div> </a> <ul id="toc-Liječenje-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Epidemiologija" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Epidemiologija"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Epidemiologija</span> </div> </a> <ul id="toc-Epidemiologija-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vanjski_linkovi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Vanjski_linkovi"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Vanjski linkovi</span> </div> </a> <ul id="toc-Vanjski_linkovi-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Uključi/isključi sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Uključi/isključi sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Policitemija vera</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Idi na članak na drugom jeziku. Dostupno na 35 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-35" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">35 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%83%D8%AB%D8%B1%D8%A9_%D8%A7%D9%84%D8%AD%D9%85%D8%B1_%D8%A7%D9%84%D8%AD%D9%82%D9%8A%D9%82%D9%8A%D8%A9" title="كثرة الحمر الحقيقية – arapski" lang="ar" hreflang="ar" data-title="كثرة الحمر الحقيقية" data-language-autonym="العربية" data-language-local-name="arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Eritremiya" title="Eritremiya – azerbejdžanski" lang="az" hreflang="az" data-title="Eritremiya" data-language-autonym="Azərbaycanca" data-language-local-name="azerbejdžanski" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Policit%C3%A8mia_vera" title="Policitèmia vera – katalonski" lang="ca" hreflang="ca" data-title="Policitèmia vera" data-language-autonym="Català" data-language-local-name="katalonski" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Polycythaemia_vera" title="Polycythaemia vera – njemački" lang="de" hreflang="de" data-title="Polycythaemia vera" data-language-autonym="Deutsch" data-language-local-name="njemački" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Polycythemia_vera" title="Polycythemia vera – engleski" lang="en" hreflang="en" data-title="Polycythemia vera" data-language-autonym="English" data-language-local-name="engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Policitemia_vera" title="Policitemia vera – španski" lang="es" hreflang="es" data-title="Policitemia vera" data-language-autonym="Español" data-language-local-name="španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Polizitemia_vera" title="Polizitemia vera – baskijski" lang="eu" hreflang="eu" data-title="Polizitemia vera" data-language-autonym="Euskara" data-language-local-name="baskijski" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%D9%84%DB%8C%E2%80%8C%D8%B3%DB%8C%D8%AA%D9%85%DB%8C_%D9%88%D8%B1%D8%A7" title="پلی‌سیتمی ورا – perzijski" lang="fa" hreflang="fa" data-title="پلی‌سیتمی ورا" data-language-autonym="فارسی" data-language-local-name="perzijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Polysytemia_vera" title="Polysytemia vera – finski" lang="fi" hreflang="fi" data-title="Polysytemia vera" data-language-autonym="Suomi" data-language-local-name="finski" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Maladie_de_Vaquez" title="Maladie de Vaquez – francuski" lang="fr" hreflang="fr" data-title="Maladie de Vaquez" data-language-autonym="Français" data-language-local-name="francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A4%D7%95%D7%9C%D7%99%D7%A6%D7%99%D7%98%D7%9E%D7%99%D7%94_%D7%95%D7%A8%D7%94" title="פוליציטמיה ורה – hebrejski" lang="he" hreflang="he" data-title="פוליציטמיה ורה" data-language-autonym="עברית" data-language-local-name="hebrejski" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Policitemija_vera" title="Policitemija vera – hrvatski" lang="hr" hreflang="hr" data-title="Policitemija vera" data-language-autonym="Hrvatski" data-language-local-name="hrvatski" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Polycythemia_vera" title="Polycythemia vera – mađarski" lang="hu" hreflang="hu" data-title="Polycythemia vera" data-language-autonym="Magyar" data-language-local-name="mađarski" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BB%D6%80%D5%A1%D5%AF%D5%A1%D5%B6_%D5%BA%D5%B8%D5%AC%D5%AB%D6%81%D5%AB%D5%BF%D5%A5%D5%B4%D5%AB%D5%A1" title="Իրական պոլիցիտեմիա – armenski" lang="hy" hreflang="hy" data-title="Իրական պոլիցիտեմիա" data-language-autonym="Հայերեն" data-language-local-name="armenski" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Policitemia_vera" title="Policitemia vera – italijanski" lang="it" hreflang="it" data-title="Policitemia vera" data-language-autonym="Italiano" data-language-local-name="italijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E7%9C%9F%E6%80%A7%E5%A4%9A%E8%A1%80%E7%97%87" title="真性多血症 – japanski" lang="ja" hreflang="ja" data-title="真性多血症" data-language-autonym="日本語" data-language-local-name="japanski" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%92%D0%B0%D0%BA%D0%B5%D0%B7%D0%B0_%D0%B0%D1%83%D1%80%D1%83%D1%8B" title="Вакеза ауруы – kazaški" lang="kk" hreflang="kk" data-title="Вакеза ауруы" data-language-autonym="Қазақша" data-language-local-name="kazaški" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%A7%84%EC%84%B1%EC%A0%81%ED%98%88%EA%B5%AC%EC%A6%9D%EA%B0%80%EC%A6%9D" title="진성적혈구증가증 – korejski" lang="ko" hreflang="ko" data-title="진성적혈구증가증" data-language-autonym="한국어" data-language-local-name="korejski" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%9F%D0%BE%D0%BB%D0%B8%D1%86%D0%B8%D1%82%D0%B5%D0%BC%D0%B8%D1%8F" title="Полицитемия – kirgiški" lang="ky" hreflang="ky" data-title="Полицитемия" data-language-autonym="Кыргызча" data-language-local-name="kirgiški" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Tikroji_policitemija" title="Tikroji policitemija – litvanski" lang="lt" hreflang="lt" data-title="Tikroji policitemija" data-language-autonym="Lietuvių" data-language-local-name="litvanski" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%9F%D0%BE%D0%BB%D0%B8%D1%86%D0%B8%D1%82%D0%B5%D0%BC%D0%B8%D1%98%D0%B0_%D0%A0%D1%83%D0%B1%D1%80%D0%B0_%D0%92%D0%B5%D1%80%D0%B0" title="Полицитемија Рубра Вера – makedonski" lang="mk" hreflang="mk" data-title="Полицитемија Рубра Вера" data-language-autonym="Македонски" data-language-local-name="makedonski" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Polycythaemia_vera" title="Polycythaemia vera – nizozemski" lang="nl" hreflang="nl" data-title="Polycythaemia vera" data-language-autonym="Nederlands" data-language-local-name="nizozemski" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AA%E0%AC%B2%E0%AC%BF%E0%AC%B8%E0%AC%BE%E0%AC%87%E0%AC%A5%E0%AD%87%E0%AC%AE%E0%AC%BF%E0%AC%86_%E0%AC%AD%E0%AD%87%E0%AC%B0%E0%AC%BE" title="ପଲିସାଇଥେମିଆ ଭେରା – odija" lang="or" hreflang="or" data-title="ପଲିସାଇଥେମିଆ ଭେରା" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odija" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Czerwienica_prawdziwa" title="Czerwienica prawdziwa – poljski" lang="pl" hreflang="pl" data-title="Czerwienica prawdziwa" data-language-autonym="Polski" data-language-local-name="poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Policitemia_vera" title="Policitemia vera – portugalski" lang="pt" hreflang="pt" data-title="Policitemia vera" data-language-autonym="Português" data-language-local-name="portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D1%81%D1%82%D0%B8%D0%BD%D0%BD%D0%B0%D1%8F_%D0%BF%D0%BE%D0%BB%D0%B8%D1%86%D0%B8%D1%82%D0%B5%D0%BC%D0%B8%D1%8F" title="Истинная полицитемия – ruski" lang="ru" hreflang="ru" data-title="Истинная полицитемия" data-language-autonym="Русский" data-language-local-name="ruski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Polycythemia_vera" title="Polycythemia vera – Simple English" lang="en-simple" hreflang="en-simple" data-title="Polycythemia vera" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Prava_policitemija" title="Prava policitemija – slovenski" lang="sl" hreflang="sl" data-title="Prava policitemija" data-language-autonym="Slovenščina" data-language-local-name="slovenski" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Polycytemia_vera" title="Polycytemia vera – švedski" lang="sv" hreflang="sv" data-title="Polycytemia vera" data-language-autonym="Svenska" data-language-local-name="švedski" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-szl mw-list-item"><a href="https://szl.wikipedia.org/wiki/Prawo_czerwjy%C5%84ica" title="Prawo czerwjyńica – Silesian" lang="szl" hreflang="szl" data-title="Prawo czerwjyńica" data-language-autonym="Ślůnski" data-language-local-name="Silesian" class="interlanguage-link-target"><span>Ślůnski</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%82%E0%B8%9E%E0%B8%A5%E0%B8%B5%E0%B9%84%E0%B8%8B%E0%B8%97%E0%B8%B5%E0%B9%80%E0%B8%A1%E0%B8%B5%E0%B8%A2_%E0%B9%80%E0%B8%A7%E0%B8%AD%E0%B8%A3%E0%B8%B2" title="โพลีไซทีเมีย เวอรา – tajlandski" lang="th" hreflang="th" data-title="โพลีไซทีเมีย เวอรา" data-language-autonym="ไทย" data-language-local-name="tajlandski" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Polisitemia_vera" title="Polisitemia vera – turski" lang="tr" hreflang="tr" data-title="Polisitemia vera" data-language-autonym="Türkçe" data-language-local-name="turski" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A1%D0%BF%D1%80%D0%B0%D0%B2%D0%B6%D0%BD%D1%8F_%D0%BF%D0%BE%D0%BB%D1%96%D1%86%D0%B8%D1%82%D0%B5%D0%BC%D1%96%D1%8F" title="Справжня поліцитемія – ukrajinski" lang="uk" hreflang="uk" data-title="Справжня поліцитемія" data-language-autonym="Українська" data-language-local-name="ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Polisitemiya" title="Polisitemiya – uzbečki" lang="uz" hreflang="uz" data-title="Polisitemiya" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="uzbečki" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-zh badge-Q70893996 mw-list-item" title=""><a href="https://zh.wikipedia.org/wiki/%E7%9C%9F%E6%80%A7%E7%BA%A2%E7%BB%86%E8%83%9E%E5%A2%9E%E5%A4%9A%E7%97%87" title="真性红细胞增多症 – kineski" lang="zh" hreflang="zh" data-title="真性红细胞增多症" data-language-autonym="中文" data-language-local-name="kineski" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span 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data-mw-deduplicate="TemplateStyles:r3638947">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data div{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data div{background:#1f1f23!important;color:#f8f9fa}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Policitemija vera</th></tr><tr><th scope="row" class="infobox-label">Drugi nazivi</th><td class="infobox-data">Policitemija vera (PV, PCV), eritremija, primarna policitemija, Vaquezova bolest, Osler-Vaquezova bolest, Policitemija rubra vera<sup id="cite_ref-britannica.com_1-0" class="reference"><a href="#cite_note-britannica.com-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><td colspan="2" class="infobox-full-data"><span typeof="mw:File"><a href="/wiki/Datoteka:Polycythemia_vera,_blood_smear.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Polycythemia_vera%2C_blood_smear.jpg/300px-Polycythemia_vera%2C_blood_smear.jpg" decoding="async" width="300" height="209" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Polycythemia_vera%2C_blood_smear.jpg/450px-Polycythemia_vera%2C_blood_smear.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/Polycythemia_vera%2C_blood_smear.jpg/600px-Polycythemia_vera%2C_blood_smear.jpg 2x" data-file-width="5872" data-file-height="4096" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data"><a href="/wiki/Krv" title="Krv">Krvni</a> razmaz pacijenta sa policitemijom verom</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medicinska_specijalnost" title="Medicinska specijalnost">Specijalnost</a></th><td class="infobox-data"><a href="/wiki/Onkologija" title="Onkologija">Onkologija</a>, <a href="/wiki/Medicinska_genetika" title="Medicinska genetika">medicinska genetika</a></td></tr><tr><th scope="row" class="infobox-label">Frekvencija</th><td class="infobox-data">1,9 u 100.000 (<a href="/wiki/Minnesota" title="Minnesota">Minnesota</a>)</td></tr></tbody></table> <p><b>Policitemija vera</b> je neuobičajena <a href="/w/index.php?title=Mijeloproliferativna_neoplazma&action=edit&redlink=1" class="new" title="Mijeloproliferativna neoplazma (stranica ne postoji)">mijeloproliferativna neoplazma</a> u kojoj <a href="/wiki/Ko%C5%A1tana_sr%C5%BE" title="Koštana srž">koštana srž</a> stvara previše <a href="/wiki/Eritrocit" class="mw-redirect" title="Eritrocit">crvenih krvnih zrnaca</a>.<sup id="cite_ref-britannica.com_1-1" class="reference"><a href="#cite_note-britannica.com-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Može također rezultirati prekomjernom proizvodnjom <a href="/wiki/Leukocit" class="mw-redirect" title="Leukocit">bijelih krvnih stanica</a> i <a href="/wiki/Trombocit" class="mw-redirect" title="Trombocit">trombocita</a>. </p><p>Većina zdravstvenih problema povezanih s policitemijom verom uzrokovana je gušćom krvi kao posljedicom povećanog broja crvenih krvnih ćelija. Češća je kod starijih osoba i može biti simptomska ili asimptomska. Uobičajeni znakovi i simptomi uključuju svrab (pruritus) i jake pekuće <a href="/wiki/Bol" title="Bol">bolove</a> u <a href="/wiki/%C5%A0aka" title="Šaka">šakama</a> ili <a href="/wiki/Stopalo" title="Stopalo">stopalima</a> koji su obično praćeni crvenkastom ili plavkastom bojom kože. Pacijenti sa ovom policitemijom imaju veću vjerovatnoću da imaju <a href="/wiki/Giht" title="Giht">gihtni artritis</a>. Liječenje se prvenstveno sastoji od <a href="/wiki/Flebotomija" title="Flebotomija">flebotomije</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Znakovi_i_simptomi">Znakovi i simptomi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=1" title="Uredi odlomak "Znakovi i simptomi"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=1" title="Edit section's source code: Znakovi i simptomi"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Erythromelalgia.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Erythromelalgia.jpg/220px-Erythromelalgia.jpg" decoding="async" width="220" height="280" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Erythromelalgia.jpg/330px-Erythromelalgia.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Erythromelalgia.jpg/440px-Erythromelalgia.jpg 2x" data-file-width="611" data-file-height="777" /></a><figcaption><a href="/w/index.php?title=Eritromelalgia&action=edit&redlink=1" class="new" title="Eritromelalgia (stranica ne postoji)">Eritromelalgia</a> je rijedak simptom PV-a, ovdje prisutan kod pacijenata sa dugotrajnom policitemijom verom. Obratiti pažnju na crvenkaste udove i otok.</figcaption></figure> <p>Osobe s policitemijom verom mogu biti <a href="/wiki/Simptom" title="Simptom">asimptomske</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Klasičan simptom je svrbež ili <a href="/wiki/Svrab" class="mw-redirect" title="Svrab">svrab</a>, posebno nakon izlaganja toploj vodi (kao kada se kupa),<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> što može biti zbog abnormalnog oslobađanja <a href="/wiki/Histamin" title="Histamin">histamina</a><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> ili proizvodnje <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandina</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Takav svrab prisutan je kod otprilike 40% pacijenata sa policitemijom verom.<sup id="cite_ref-pvsg_7-0" class="reference"><a href="#cite_note-pvsg-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Giht" title="Giht">gihtni artritis</a> može biti prisutan kod do 20% pacijenata.<sup id="cite_ref-pvsg_7-1" class="reference"><a href="#cite_note-pvsg-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <a href="/w/index.php?title=Peptozna_ulkusna_bolest&action=edit&redlink=1" class="new" title="Peptozna ulkusna bolest (stranica ne postoji)">Peptozna ulkusna bolest</a> je takođe česta kod pacijenata sa policitemijom verom; najvjerovatnije zbog povećanog histamina iz <a href="/wiki/Mastocit" title="Mastocit">mastocita</a>, ali može biti povezano s povećanom osjetljivošću na <a href="/wiki/Infekcije" class="mw-redirect" title="Infekcije">infekcije</a> bakterijom koja uzrokuje <a href="/w/index.php?title=%C4%8Cir_na_%C5%BEelucu&action=edit&redlink=1" class="new" title="Čir na želucu (stranica ne postoji)">čir na želucu</a>, <i><a href="/wiki/Helicobacter_pylori" title="Helicobacter pylori">H. pylori</a></i>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Drugi mogući mehanizam za nastanak peptoznog čira je pojačano oslobađanje <a href="/wiki/Histamin" title="Histamin">histamina</a> i želučana hiperkiselost. </p><p>Klasičan simptom policitemije vere (i srodne mijeloproliferativne bolesti <a href="/w/index.php?title=Esencijalna_trombocitemija&action=edit&redlink=1" class="new" title="Esencijalna trombocitemija (stranica ne postoji)">esencijalna trombocitemija</a>) je <a href="/wiki/Eritromelalgija" title="Eritromelalgija">eritromelalgija</a>.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Ovo je pekući bolno u <a href="/wiki/%C5%A0aka" title="Šaka">šakama</a> ili stopalima, obično praćeno crvenkastom ili <a href="/wiki/Cijanoza" title="Cijanoza">plavkastom</a> bojom kože. Eritromelalgija je uzrokovana povećanim brojem <a href="/wiki/Trombocit" class="mw-redirect" title="Trombocit">trombocita</a> ili povećanom "ljepljivošću" (agregacijom ) trombocita, što rezultira stvaranjem sitnih krvnih ugrušaka u žilama ekstremiteta; brzo reaguje na terapiju sa <a href="/wiki/Aspirin" title="Aspirin">aspirinom</a>.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>Bolesnici skloni su razvoju krvnih ugrušaka (<a href="/wiki/Tromboza" title="Tromboza">tromboza</a>). Velika trombotska komplikacija (npr. <a href="/wiki/Infarkt_miokarda" title="Infarkt miokarda">srčani udar</a>, <a href="/wiki/Mo%C5%BEdani_udar" title="Moždani udar">moždani udar</a>, <a href="/w/index.php?title=Duboka_venska_tromboza&action=edit&redlink=1" class="new" title="Duboka venska tromboza (stranica ne postoji)">duboka venska tromboza</a> ili <a href="/w/index.php?title=Budd-Chiarijev_sindrom&action=edit&redlink=1" class="new" title="Budd-Chiarijev sindrom (stranica ne postoji)">Budd-Chiarijev sindrom</a>) ponekad mogu biti prvi simptom ili indikacija da osoba ima policitemiju veru. <a href="/wiki/Glavobolje" class="mw-redirect" title="Glavobolje">Glavobolje</a>, nedostatak koncentracije i umor su uobičajeni simptomi koji se javljaju i kod pacijenata sa ovom policitemijom. </p> <div class="mw-heading mw-heading2"><h2 id="Patofiziologija">Patofiziologija</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=2" title="Uredi odlomak "Patofiziologija"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=2" title="Edit section's source code: Patofiziologija"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Policitemija vera (PCV), kao primarna <a href="/wiki/Policitemija" title="Policitemija">policitemija</a>, uzrokovana je <a href="/wiki/Neoplazma" title="Neoplazma">neoplazmatskom</a> proliferacijom i sazrijevanjem <a href="/wiki/Eritrocit" class="mw-redirect" title="Eritrocit">eritroida</a>, <a href="/w/index.php?title=Megakariocit&action=edit&redlink=1" class="new" title="Megakariocit (stranica ne postoji)">megakariocita</a> i <a href="/wiki/Granulocit" class="mw-redirect" title="Granulocit">granulocitnih</a> elemenata za proizvodnju onoga što se naziva <a href="/w/index.php?title=Panmijeloza&action=edit&redlink=1" class="new" title="Panmijeloza (stranica ne postoji)">panmijeloza</a>. Za razliku od sekundarnih policitemija, PCV je povezana sa niskim <a href="/wiki/Krvni_serum" class="mw-redirect" title="Krvni serum">serumskim</a> nivoom <a href="/wiki/Hormon" title="Hormon">hormona</a> <a href="/wiki/Eritropoetin" title="Eritropoetin">eritropoetina</a> (EPO). Umjesto toga, PCV ćelije često nose aktivirajuću mutaciju u genu <a href="/wiki/Tirozin-kinaze" class="mw-redirect" title="Tirozin-kinaze">tirozin-kinaze</a> (<a href="/w/index.php?title=JAK2&action=edit&redlink=1" class="new" title="JAK2 (stranica ne postoji)">JAK2</a>), koji djeluje na signalnim putevima EPO-receptora, čineći te ćelije <a href="/wiki/%C4%86elijska_proliferacija" title="Ćelijska proliferacija">proliferacijski</a> neovisnim o EPO.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Dijagnoza">Dijagnoza</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=3" title="Uredi odlomak "Dijagnoza"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=3" title="Edit section's source code: Dijagnoza"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nalazi <a href="/wiki/Fenotipski_pregled" title="Fenotipski pregled">fizičkog pregleda</a> su nespecifični, ali mogu uključivati <a href="/wiki/Hepatosplenomegalija" title="Hepatosplenomegalija">uvećanu jetru</a> ili <a href="/wiki/Slezena" title="Slezena">slezenu</a>, pocrvenjele otekline ili <a href="/wiki/Giht" title="Giht">gihtne čvorove</a>. Na dijagnozu se često sumnja na osnovu laboratorijskih pretraga. Uobičajeni nalazi uključuju povišen nivo <a href="/wiki/Hemoglobin" title="Hemoglobin">hemoglobina</a> i <a href="/w/index.php?title=Hematokrit&action=edit&redlink=1" class="new" title="Hematokrit (stranica ne postoji)">hematokrita</a>, što odražava povećan broj <a href="/wiki/Eritrocit" class="mw-redirect" title="Eritrocit">crvenih krvnih zrnaca</a>; broj <a href="/wiki/Trombocit" class="mw-redirect" title="Trombocit">trombocita</a> ili broj <a href="/wiki/Leukocit" class="mw-redirect" title="Leukocit">bijelih krvnih ćelija</a> također može biti povećan. <a href="/w/index.php?title=Brzina_sedimentacije_eritrocita&action=edit&redlink=1" class="new" title="Brzina sedimentacije eritrocita (stranica ne postoji)">brzina sedimentacije eritrocita</a> (ESR) je smanjena zbog povećanja <a href="/wiki/Zeta_potencijal" title="Zeta potencijal">zeta potencijala</a>. Budući da je policitemija vera rezultat značajnog povećanja proizvodnje eritrocita, pacijenti imaju normalnu oksigenaciju krvi i nizak nivo <a href="/wiki/Eritropoetin" title="Eritropoetin">eritropoetina</a> (EPO). </p><p>U primarnoj policitemiji može biti 8–9 miliona, a ponekad i 11 miliona eritrocita po kubnom milimetru krvi (normalan raspon za odrasle je 4–6), a <a href="/w/index.php?title=Hematokrit&action=edit&redlink=1" class="new" title="Hematokrit (stranica ne postoji)">hematokrit</a> može biti čak 70 do 80%. Osim toga, ukupan volumen krvi se ponekad povećava na čak dva puta u odnosu na normalni. Čitav <a href="/wiki/Vaskularni_sistem" class="mw-redirect" title="Vaskularni sistem">vaskularni sistem</a> može biti izrazito natrpan krvlju, a vrijeme cirkulacije krvi u cijelom tijelu može se povećati i do dva puta u odnosu na normalnu vrijednost. Povećani broj <a href="/wiki/Eritrocit" class="mw-redirect" title="Eritrocit">eritrocita</a> može uzrokovati povećanje <a href="/wiki/Viskoznost" title="Viskoznost">viskoznosti</a> krvi čak pet puta. Vrlo viskozna krv može začepiti kapilare, a protok krvi kroz krvne žile može biti izuzetno usporen. </p><p>Kao posljedica gore navedenog, osobe s neliječenom policitemijom verom izložene su riziku od raznih <a href="/wiki/Tromboza" title="Tromboza">trombotskih</a> poremećaja (<a href="/w/index.php?title=Duboka_venska_tromboza&action=edit&redlink=1" class="new" title="Duboka venska tromboza (stranica ne postoji)">duboka venska tromboza</a>, <a href="/w/index.php?title=Plu%C4%87na_embolija&action=edit&redlink=1" class="new" title="Plućna embolija (stranica ne postoji)">plućna embolija</a>), <a href="/wiki/Infarkt_miokarda" title="Infarkt miokarda">srčani udar </a> i <a href="/wiki/Mo%C5%BEdani_udar" title="Moždani udar">moždani udar</a>, a imaju i značajan rizik od <a href="/w/index.php?title=Budd-Chiarijev_sindrom&action=edit&redlink=1" class="new" title="Budd-Chiarijev sindrom (stranica ne postoji)"> Budd-Chiarijevog sindroma</a> (tromboze jetrenih <a href="/wiki/Vena" title="Vena">vena</a>),<sup id="cite_ref-pmid16827884_13-0" class="reference"><a href="#cite_note-pmid16827884-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> ili <a href="/w/index.php?title=Mijelofibroza&action=edit&redlink=1" class="new" title="Mijelofibroza (stranica ne postoji)">mijelofibroza</a>. </p><p><a href="/wiki/Mutacija" title="Mutacija">Mutacija</a> u <a href="/w/index.php?title=JAK2&action=edit&redlink=1" class="new" title="JAK2 (stranica ne postoji)">JAK2</a> <a href="/wiki/Kinaza" title="Kinaza">kinaznom</a> genu(V617F) snažno je povezana s policitemijom verom.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> <i>JAK2</i> je član porodice <a href="/w/index.php?title=Janus-kinaza&action=edit&redlink=1" class="new" title="Janus-kinaza (stranica ne postoji)">Janus-kinaza</a> i čini prekursore eritroida preosjetljivim na eritropoetin (EPO). Ova mutacija može biti od pomoći u postavljanju dijagnoze ili kao meta za buduću terapiju. </p><p>Nakon anamneze i pregleda, Britanski komitet za standarde u hematologiji (BCSH) preporučuje da se urade sljedeći testovi: </p> <ul><li>puna krvna slika/film (povišeni <a href="/w/index.php?title=Hematokrit&action=edit&redlink=1" class="new" title="Hematokrit (stranica ne postoji)">hematokrit</a>; <a href="/wiki/Neutrofil" class="mw-redirect" title="Neutrofil">neutrofili</a>, <a href="/wiki/Bazofil" class="mw-redirect" title="Bazofil">bazofili</a>, <a href="/wiki/Trombocit" class="mw-redirect" title="Trombocit">trombociti</a> povišeni kod polovine pacijenata)</li> <li>JAK2 <a href="/wiki/Mutacija" title="Mutacija">mutacija</a></li> <li>serumski feritin</li> <li>testovi funkcije <a href="/wiki/Bubreg" title="Bubreg">bubrega</a> i <a href="/wiki/Jetra" title="Jetra">jetre</a></li></ul> <p>Ako je mutacija JAK2 negativna i nema očiglednih sekundarnih uzroka, BCSH predlaže sljedeće testove: </p> <ul><li>masa <a href="/wiki/Eritrocit" class="mw-redirect" title="Eritrocit">crvenih krvnih zrnaca</a></li> <li>arterijska <a href="/w/index.php?title=Zasi%C4%87enost_kisikom&action=edit&redlink=1" class="new" title="Zasićenost kisikom (stranica ne postoji)">zasićenost kisikom</a></li> <li><a href="/wiki/Ultrazvuk" title="Ultrazvuk">ultrazvuk</a> <a href="/wiki/Abdomen" class="mw-redirect" title="Abdomen">abdomena</a></li> <li>nivo <a href="/wiki/Eritropoetin" title="Eritropoetin">eritropoetina</a> u <a href="/wiki/Krvni_serum" class="mw-redirect" title="Krvni serum">serumu</a></li> <li><a href="/wiki/Ko%C5%A1tana_sr%C5%BE" title="Koštana srž">koštana srž</a>: <a href="/w/index.php?title=Aspiracija_ko%C5%A1tane_sr%C5%BEi&action=edit&redlink=1" class="new" title="Aspiracija koštane srži (stranica ne postoji)">aspirat</a> i <a href="/w/index.php?title=Trefin&action=edit&redlink=1" class="new" title="Trefin (stranica ne postoji)">trefin</a></li> <li><a href="/wiki/Citogenetika" title="Citogenetika">citogenetička analiza</a></li> <li>kultura jedinice formiranja eritroida (BFU-E).</li></ul> <p>Ostale karakteristike koje se mogu vidjeti kod policitemije vere uključuju nizak ESR i povišenu razinu alkalnne <a href="/wiki/Fosfataza" title="Fosfataza">fosfataze</a> leukocita. </p><p>BCSH je nedavno ažurirao dijagnostičke kriterijume za policitemiju veru. Ovo zamjenjuje prethodne kriterije studijske grupe policitemije vere. JAK2-pozitivna policitemija vera – dijagnoza zahtijeva da postoje oba kriterija: </p> <table class="wikitable"> <tbody><tr> <th>Kriteriji </th> <th>Napomena </th></tr> <tr> <td>A1 </td> <td>Visoka <a href="/w/index.php?title=Volumna_frakcija_eritrocita&action=edit&redlink=1" class="new" title="Volumna frakcija eritrocita (stranica ne postoji)">volumna frakcija eritrocita</a> (EVF ili <a href="/w/index.php?title=Hematokrit&action=edit&redlink=1" class="new" title="Hematokrit (stranica ne postoji)">hematokrit</a>) (>0,52 kod muškaraca, >0,48 kod žena) ili povećana masa crvenih krvnih zrnaca ( >25% iznad predviđene) </td></tr> <tr> <td>A2 </td> <td><a href="/wiki/Mutacija" title="Mutacija">Mutacija</a> gena JAK2 </td></tr></tbody></table> <p>JAK2-negativna policitemija vera – dijagnoza zahtijeva A1 + A2 + A3 + ili drugi A ili dva B kriterija: </p> <table class="wikitable"> <tbody><tr> <th>Kriteriji </th> <th>Napomena </th></tr> <tr> <td>A1 </td> <td>Povećana masa crvenih krvnih zrnaca (>25% iznad predviđene) ili hematokrit >0,60 kod muškaraca, >0,56 kod žena) </td></tr> <tr> <td>A2 </td> <td>Bez mutacije JAK2 </td></tr> <tr> <td>A3 </td> <td>Nema uzroka sekundarne eritrocitoze </td></tr> <tr> <td>A4 </td> <td>Palpabilna splenomegalija (uvećana <a href="/wiki/Slezena" title="Slezena">slezena</a>) </td></tr> <tr> <td>A5 </td> <td>Prisustvo stečene genetičke abnormalnosti (isključujući BCR-ABL) u <a href="/wiki/Hematopoeza" title="Hematopoeza">hematopoetskim</a> ćelijama </td></tr> <tr> <td>B1 </td> <td><a href="/w/index.php?title=Trombocitoza&action=edit&redlink=1" class="new" title="Trombocitoza (stranica ne postoji)">Trombocitoza</a> (broj <a href="/wiki/Trombocit" class="mw-redirect" title="Trombocit">trombocita</a> >450 * 109/l) </td></tr> <tr> <td>B2 </td> <td><a href="/wiki/Neutrofil" class="mw-redirect" title="Neutrofil">Neutrofilna</a> <a href="/w/index.php?title=Leukocitoza&action=edit&redlink=1" class="new" title="Leukocitoza (stranica ne postoji)">leukocitoza</a> (broj neutrofila > 10 * 109/l kod nepušača; > 12,5*109/l kod pušača) </td></tr> <tr> <td>B3 </td> <td><a href="/wiki/Radiologija" title="Radiologija">Radiološki</a> dokaz splenomegalije </td></tr> <tr> <td>B4 </td> <td><a href="/wiki/Endogen" title="Endogen">Endogene</a> eritroidne kolonije ili nizak serumski <a href="/wiki/Eritropoetin" title="Eritropoetin">eritropoetin</a> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Liječenje"><span id="Lije.C4.8Denje"></span>Liječenje</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=4" title="Uredi odlomak "Liječenje"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=4" title="Edit section's source code: Liječenje"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Neliječena, policitemija vera može biti fatalna.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Podaci o učinku na životni vijek osobaa s policitemija vera su neuvjerljivi zbog rijetkosti bolesti, pri čemu neki izvori navode normalan životni vijek, a drugi navode srednju stopu preživljavanja od 10-20 godina.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Flebotomija" title="Flebotomija">Flebotomija</a> je jedan oblik liječenja, koji se često može kombinirati s drugim terapijama. Uklanjanje krvi iz organizma izaziva nedostatak <a href="/wiki/Gvo%C5%BE%C4%91e" class="mw-redirect" title="Gvožđe">gvožđa</a>, čime se smanjuje nivo <a href="/wiki/Hemoglobin" title="Hemoglobin">hemoglobina</a>/hematokrita i smanjuje rizik od nastanka krvnih ugrušaka. Flebotomija se obično izvodi kako bi se njihov <a href="/w/index.php?title=Hematokrit&action=edit&redlink=1" class="new" title="Hematokrit (stranica ne postoji)">hematokrit</a> (procenat crvenih krvnih zrnaca) smanjio ispod 45 za muškarce ili 42 za žene.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> It has been observed that phlebotomy also reduces cognitive impairment (improves cognition).<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>Tendencija nekih praktičara da izbjegavaju <a href="/wiki/Hemoterapija" title="Hemoterapija">hemoterapiju</a> ako je to moguće, posebno kod mladih pacijenata, rezultat je istraživanja koja ukazuju na mogući povećani rizik od transformacije u <a href="/wiki/Akutna_mijeloidna_leukemija" title="Akutna mijeloidna leukemija">akutnu mijelogena leukemiju (AML)</a>. Dok se hidroksi<a href="/wiki/Urea" title="Urea">urea</a> smatra sigurnijom u ovom aspektu, još uvijek se vode rasprave o njenoj dugoročnoj sigurnosti.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p><p>Postoje indicije da s određenim <a href="/wiki/Geneti%C4%8Dki_marker" title="Genetički marker">genetičkim markerima</a>, <a href="/w/index.php?title=Erlotinib&action=edit&redlink=1" class="new" title="Erlotinib (stranica ne postoji)">erlotinib</a> može biti dodatna opcija liječenja za ovo stanje.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>Inhibitor <a href="/w/index.php?title=Janus-kinaza_2&action=edit&redlink=1" class="new" title="Janus-kinaza 2 (stranica ne postoji)">Janus-kinaze 2</a> (JAK2), <a href="/w/index.php?title=Ruksolitinib&action=edit&redlink=1" class="new" title="Ruksolitinib (stranica ne postoji)">ruksolitinib</a>, koristi se također za liječenje policitemije.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p><p><a href="/w/index.php?title=Ropeginterferon_alfa-2b&action=edit&redlink=1" class="new" title="Ropeginterferon alfa-2b (stranica ne postoji)">Ropeginterferon alfa-2b</a> (Besremi) odobren je za medicinsku upotrebu u Evropskoj uniji, u februaru 2019.<sup id="cite_ref-Besremi_EPAR_25-0" class="reference"><a href="#cite_note-Besremi_EPAR-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> and in the United States in November 2021.<sup id="cite_ref-FDA_PR_20211112_26-0" class="reference"><a href="#cite_note-FDA_PR_20211112-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PharmaEssentia_PR_27-0" class="reference"><a href="#cite_note-PharmaEssentia_PR-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Ropeginterferon alfa-2b je prvi lijek koji je odobrila Agencija za hranu i lijekove (FDA) <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a>-a za liječenje policitemije vere koju ljudi mogu uzimati bez obzira na njihovu povijest liječenja, i prva je terapija <a href="/wiki/Interferon" title="Interferon">interferonom</a> koja je posebno odobrena za policitemiju veru.<sup id="cite_ref-FDA_PR_20211112_26-1" class="reference"><a href="#cite_note-FDA_PR_20211112-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiologija">Epidemiologija</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=5" title="Uredi odlomak "Epidemiologija"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=5" title="Edit section's source code: Epidemiologija"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Policitemija vera javlja se u svim starosnim grupama,<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> iako se incidencija povećava sa godinama. Jedna studija je pokazala da je srednja starost pri postavljanju dijagnoze bila 60 godina,<sup id="cite_ref-pvsg_7-2" class="reference"><a href="#cite_note-pvsg-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> dok je studija Mayo klinike u okrugu Olmsted, <a href="/wiki/Minnesota" title="Minnesota">Minnesota</a> otkrila da je najveća incidencija bila kod ljudi u dobi od 70 do 79 godina.<sup id="cite_ref-olmsted_29-0" class="reference"><a href="#cite_note-olmsted-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> Ukupna incidencija u populaciji Minnesote bila je 1,9 na 100.000 čovjek-godina, a bolest je bila češća kod muškaraca nego žena.<sup id="cite_ref-olmsted_29-1" class="reference"><a href="#cite_note-olmsted-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> Grupa oko toksičnog mjesta potvrđena je u sjeveroistočnoj Pensilvaniji 2008..<sup id="cite_ref-NEPennsylvania_30-0" class="reference"><a href="#cite_note-NEPennsylvania-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=6" title="Uredi odlomak "Reference"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=6" title="Edit section's source code: Reference"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3312388">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-britannica.com-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-britannica.com_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-britannica.com_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.britannica.com/EBchecked/topic/468448/polycythemia-vera">"polycythemia vera." at Encyclopædia Britannica.</a> 2010. 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Arhivirano s <a rel="nofollow" class="external text" href="https://news.yahoo.com/s/ap/20080826/ap_on_sc/toxic_dump_fears">originala</a>, September 2, 2008.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Associated+Press&rft.atitle=Cancer+cluster+confirmed+in+northeast+Pennsylvania&rft.date=2008&rft.au=MICHAEL+RUBINKAM&rft_id=https%3A%2F%2Fnews.yahoo.com%2Fs%2Fap%2F20080826%2Fap_on_sc%2Ftoxic_dump_fears&rfr_id=info%3Asid%2Fbs.wikipedia.org%3APolicitemija+vera" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Vanjski_linkovi">Vanjski linkovi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Policitemija_vera&veaction=edit&section=7" title="Uredi odlomak "Vanjski linkovi"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Policitemija_vera&action=edit&section=7" title="Edit section's source code: Vanjski linkovi"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="noprint portal tright" style="border:solid #aaa 1px;margin:0.5em 0 0.5em 1em"> <table style="background:#f9f9f9;font-size:85%;line-height:110%;max-width:175px"> <tbody><tr style="vertical-align:middle"><td style="text-align:center"><span class="noviewer" typeof="mw:File"><span><img alt="Portal icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/12px-WHO_Rod.svg.png" decoding="async" width="12" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/18px-WHO_Rod.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/24px-WHO_Rod.svg.png 2x" data-file-width="107" data-file-height="250" /></span></span></td><td style="padding:0 0.2em;vertical-align:middle;font-style:italic;font-weight:bold"><a href="/wiki/Portal:Medicina" title="Portal:Medicina">Portal Medicina</a></td></tr></tbody></table></div> <ul><li><a rel="nofollow" class="external text" href="https://www.nhlbi.nih.gov/health-topics/polycythemia-vera">Polycythemia Vera</a> National Heart, Lung, and Blood Institute</li> <li><a rel="nofollow" class="external text" href="http://www.merck.com/mmpe/sec11/ch141/ch141d.html">11-141d.</a> u <i><a href="/w/index.php?title=Merck_Manual_of_Diagnosis_and_Therapy&action=edit&redlink=1" class="new" title="Merck Manual of Diagnosis and Therapy (stranica ne postoji)">Merck Manual of Diagnosis and Therapy</a></i> Professional Edition</li></ul> <div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0">Klasifikacija</th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q948318" class="extiw" title="d:Q948318">D</a></div><div class="hlist hlist-separated" style="text-align:left;"><ul><li><b><a href="/wiki/Medicinske_klasifikacije" title="Medicinske klasifikacije">ICD</a>-<a href="/w/index.php?title=ICD-10&action=edit&redlink=1" class="new" title="ICD-10 (stranica ne postoji)">10</a></b>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/D45">D45</a></li><li><b><a href="/wiki/Medicinske_klasifikacije" title="Medicinske klasifikacije">ICD</a>-<a href="/w/index.php?title=Spisak_ICD-9_kodova&action=edit&redlink=1" class="new" title="Spisak ICD-9 kodova (stranica ne postoji)">9-CM</a></b>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=238.4">238.4</a></li><li><b><a href="/w/index.php?title=Me%C4%91unarodna_klasifikacija_onkolo%C5%A1kih_bolesti&action=edit&redlink=1" class="new" title="Međunarodna klasifikacija onkoloških bolesti (stranica ne postoji)">ICD-O</a></b>: <a rel="nofollow" class="external text" href="https://progenetix.org/subsets/?term_id=icdom:9950_3">M9950/3</a></li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&term=D011087">D011087</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0">Vanjski resursi</th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"><div class="hlist hlist-separated" 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