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class='flex_column av-av_one_half-2a9015ff38129c418a3f2eafba3e9512 av_one_half first flex_column_div ' ><p class="sub-heading">Pixel technology</p> <h1>Cell biology discovery powered by microchips</h1> <p>Our breakthrough semiconductor-to-live-cell interface enables the capture of electrical, electrochemical, and electrophysiological data on live cells, delivering multi-modal, real-time readouts at single-cell resolution.</p></div> <div class='flex_column av-av_one_half-52c89597409f646e66e7cc675a5d9b4a av_one_half flex_column_div ' ><div class="technology-video"><a id="674ad84a65e8f" rel="wp-video-lightbox" href="https://vimeo.com/1022962136?width=640&height=480" title=""><img src="https://cytotronics.com/wp-content/uploads/2024/10/GRAPHIC-VideoScreenshot-wBackground-2.webp" class="video_lightbox_anchor_image" alt="" /></a> <script type="rocketlazyloadscript"> /* <![CDATA[ */ jQuery(document).ready(function($){ $(function(){ var width = $(window).innerWidth(); var setwidth = 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post-entry-type-page post-entry-637'><div class='entry-content-wrapper clearfix'> <div class='flex_column_table av-6nbwf-ca1e2babdfb6f8d40a3db08036930847 sc-av_one_half av-mobile-columns-flex av-columns-reverse av-equal-height-column-flextable'><div class='flex_column av-6nbwf-ca1e2babdfb6f8d40a3db08036930847 av_one_half avia-builder-el-1 el_before_av_one_half avia-builder-el-first first flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic fade-in ' ><style type="text/css" data-created_by="avia_inline_auto" id="style-css-av-lp1hlxpj-8bb459a0c4997618d2b072843b65f2bc"> .avia-image-container.av-lp1hlxpj-8bb459a0c4997618d2b072843b65f2bc img.avia_image{ box-shadow:none; } .avia-image-container.av-lp1hlxpj-8bb459a0c4997618d2b072843b65f2bc .av-image-caption-overlay-center{ color:#ffffff; } </style> <div class='avia-image-container av-lp1hlxpj-8bb459a0c4997618d2b072843b65f2bc av-styling- avia_animated_image av-animated-when-visible-95 fade-in avia-align-center avia-builder-el-2 avia-builder-el-no-sibling video-image' itemprop="image" itemscope="itemscope" itemtype="https://schema.org/ImageObject" ><div class="avia-image-container-inner"><div class="avia-image-overlay-wrap"><img fetchpriority="high" decoding="async" class='wp-image-1501 avia-img-lazy-loading-not-1501 avia_image ' src="https://cytotronics.com/wp-content/uploads/2024/10/GRAPHIC-Cyto_plate_layers-d3.webp" alt='Graphic showing Pixel 96-well plate and images of wet-lab biology, data science pipeline and data on live-cell insights' title='Pixel 96-well plate and images of wet-lab biology, data science pipeline and data on live-cell insights' height="638" width="1000" itemprop="thumbnailUrl" srcset="https://cytotronics.com/wp-content/uploads/2024/10/GRAPHIC-Cyto_plate_layers-d3.webp 1000w, https://cytotronics.com/wp-content/uploads/2024/10/GRAPHIC-Cyto_plate_layers-d3-300x191.webp 300w, https://cytotronics.com/wp-content/uploads/2024/10/GRAPHIC-Cyto_plate_layers-d3-768x490.webp 768w, https://cytotronics.com/wp-content/uploads/2024/10/GRAPHIC-Cyto_plate_layers-d3-705x450.webp 705w" sizes="(max-width: 1000px) 100vw, 1000px" /></div></div></div></div><div class='av-flex-placeholder'></div><div class='flex_column av-lp1hmtet-620570b795d01d0cd354e219d3075453 av_one_half avia-builder-el-3 el_after_av_one_half avia-builder-el-last flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic fade-in ' ><section class='av_textblock_section av-lp1hmpmw-c458b501e6b830285ac1381d6df5b092 ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><h2 style="text-align: left;">Data-rich live cell insights</h2> <p>Pixel plates are at the core of our systems, and a wide range of biological coatings enables plating of any cell type, spheroid or 3D organoid system. These proprietary 96- or 384-well microplates are embedded with custom-designed CMOS microchips at the base of each well, which provide thousands of measurement and stimulation electrodes.</p> <p>Live cells grow in culture media on top of high-density electrode arrays. Multiparametric real-time readouts are captured at single-cell resolution, and the data can be quickly analyzed using our interactive, cloud-based Pixel Pro software.</p> </div></section> <div class='hr av-lrzg1o0e-f14facf3a7880390fe81055bc6734663 hr-invisible avia-builder-el-5 el_after_av_textblock avia-builder-el-last '><span class='hr-inner '><span class="hr-inner-style"></span></span></div></div></div> </div></div></main></div></div><div id='av_section_2' class='avia-section av-9scd-078d8c1fe4ea6c01f178feef4dbcb145 main_color avia-section-default avia-no-border-styling avia-builder-el-6 el_after_av_section el_before_av_section avia-bg-style-scroll container_wrap fullsize' ><div class='container av-section-cont-open' ><div class='template-page content av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-637'><div class='entry-content-wrapper clearfix'> <div class='flex_column_table av-iwagl-e53c4a5c6c14c34c754417a3579895a4 sc-av_one_full av-mobile-columns-flex av-columns-reverse av-equal-height-column-flextable'><div class='flex_column av-iwagl-e53c4a5c6c14c34c754417a3579895a4 av_one_full avia-builder-el-7 el_before_av_one_third avia-builder-el-first first flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic fade-in ' ><section class='av_textblock_section av-m2mnf86r-4f43cd8b96f5b3d575a04f848f690d6b ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><h2 style="text-align: left;">Multi-modal live cell monitoring</h2> <p>Contemporary tools offer a single readout modality and compromise between spatial resolution and throughput. The high-dimensional data, spatial images and longitudinal videos Pixel generates enables data collection at a scale that wasn’t possible before on the same cell culture. Capture simultaneous multi-modal readouts for:</p> </div></section></div></div><div class='flex_column_table av-18gk39-6975fefa3a1447f463649805dfb20b78 sc-av_one_third av-mobile-columns-flex av-columns-reverse av-equal-height-column-flextable'><div class='flex_column av-18gk39-6975fefa3a1447f463649805dfb20b78 av_one_third avia-builder-el-9 el_after_av_one_full el_before_av_one_third first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic fade-in av-hide-on-mobile column-top-margin' ><section class='av_textblock_section av-m2mnwynj-79f190b9900c18e3f96c2b18a3f84616 ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><ul> <li>Cell proliferation and real-time viability</li> <li>Tissue barrier and cell-cell adhesion</li> <li>Motility and migration</li> </ul> </div></section></div><div class='av-flex-placeholder'></div><div class='flex_column av-3ak8l-a83d28f9bd3270950699abff3172c09e av_one_third avia-builder-el-11 el_after_av_one_third el_before_av_one_third flex_column_table_cell av-equal-height-column av-align-top av-animated-generic fade-in av-hide-on-mobile column-top-margin' ><section class='av_textblock_section av-m2mnvijb-3e68bf76426cec515e249343f7f0392f ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><ul> <li>Cell substrate attachment</li> <li>Culture heterogeneity</li> <li>Cytotoxicity and cell death</li> </ul> </div></section></div><div class='av-flex-placeholder'></div><div class='flex_column av-1xral-7f5e91797d296895164ad922e6c0deea av_one_third avia-builder-el-13 el_after_av_one_third el_before_av_one_full flex_column_table_cell av-equal-height-column av-align-top av-animated-generic fade-in av-hide-on-mobile column-top-margin' ><section class='av_textblock_section av-m2mnw47v-2a44395dbe95fcabb8ab137f01a7875f ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><ul> <li>Cardiac electrophysiology</li> <li>Contractility</li> <li>Neural activity</li> </ul> </div></section></div></div><div class='av-column-wrapper-individual av-mobile-columns-flex av-columns-reverse'><div class='flex_column av-m2mxug2x-abb21ea46667ca5bc46496bc9fe5b5b2 av_one_full avia-builder-el-15 el_after_av_one_third el_before_av_hr first flex_column_div av-animated-generic bottom-to-top column-top-margin' ><section class='av_textblock_section av-m2mxsva8-b2bc0d05eb05837cc0582d52b4e75885 ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='av-desktop-hide av-medium-hide avia_textblock' itemprop="text" ><ul> <li>Cell proliferation and real-time viability</li> <li>Tissue barrier and cell-cell adhesion</li> <li>Motility and migration</li> <li>Cell substrate attachment</li> <li>Culture heterogeneity</li> <li>Cytotoxicity and cell death</li> <li>Cardiac electrophysiology</li> <li>Contractility</li> <li>Neural activity</li> </ul> </div></section></div></div><div class='hr av-m2myjjji-be996404857ccb6b0cb82fc603e8c8b6 hr-invisible avia-builder-el-17 el_after_av_one_full avia-builder-el-last av-desktop-hide av-medium-hide'><span class='hr-inner '><span class="hr-inner-style"></span></span></div> </div></div></div></div></div><div id='av_section_3' class='avia-section av-42nfwl-db97c2ca15866eb4663e81ada046570c main_color avia-section-no-padding avia-no-border-styling avia-builder-el-18 el_after_av_section el_before_av_section bottom-border avia-bg-style-scroll container_wrap fullsize' ><div class='container av-section-cont-open' ><div class='template-page content av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-637'><div class='entry-content-wrapper clearfix'> <div class='flex_column_table av-3uhnil-22770205e70533216c355a6a3db27c1a sc-av_one_third av-equal-height-column-flextable'><div class='flex_column av-3uhnil-22770205e70533216c355a6a3db27c1a av_one_third avia-builder-el-19 el_before_av_one_third avia-builder-el-first first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic fade-in ' ><section class="avia_codeblock_section avia_code_block_0" itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_codeblock epithelial-video' itemprop="text" ><a id="674ad84a66ee3" rel="wp-video-lightbox" href="https://vimeo.com/1022967617?width=640&height=480" title=""><img src="https://cytotronics.com/wp-content/uploads/2024/10/MDCK-2-d4.webp" class="video_lightbox_anchor_image" alt="" /></a> <script type="rocketlazyloadscript"> /* <![CDATA[ */ jQuery(document).ready(function($){ $(function(){ var width = $(window).innerWidth(); var setwidth = parseFloat(640); var ratio = parseFloat(0.75); var height = parseFloat(480); var link = 'https://vimeo.com/1022967617?width=640&height=480'; if(width < setwidth) { height = Math.floor(width * 0.75); //console.log("device width "+width+", set width "+640+", ratio "+0.75+", new height "+ height); var new_url = wpvl_paramReplace('width', link, width); var new_url = wpvl_paramReplace('height', new_url, height); $("a#674ad84a66ee3").attr('href', new_url); //console.log(new_url); } }); }); /* ]]> */ </script></div></section> <div class='av-special-heading av-3nogct-0798e6b3728c4c5b58327bde68106f9f av-special-heading-h3 blockquote modern-quote avia-builder-el-21 el_after_av_codeblock el_before_av_textblock '><h3 class='av-special-heading-tag' itemprop="headline" >Epithelial cell growth</h3><div class="special-heading-border"><div class="special-heading-inner-border"></div></div></div> <section class='av_textblock_section av-3k4vrh-aa76e259a9abab1ce21182a228e21bbf ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock no-top-padding' itemprop="text" ><p style="text-align: left;">Epithelial sheets are living, breathing dynamic structures, exhibiting long-range motion and flow of cells in the sheet. Pixel electrical imaging lets you observe and quantify this behavior label free, at scale. Watch kidney epithelial cells grow, form connections and interact in a sheet.</p> </div></section></div><div class='av-flex-placeholder'></div><div class='flex_column av-c9ddp-703658e746f52aa00e1f1a18dcf38f09 av_one_third avia-builder-el-23 el_after_av_one_third el_before_av_one_third flex_column_table_cell av-equal-height-column av-align-top av-animated-generic fade-in ' ><section class="avia_codeblock_section avia_code_block_1" itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_codeblock motility-video' itemprop="text" ><a id="674ad84a66fe5" rel="wp-video-lightbox" href="https://vimeo.com/1022967407?width=640&height=480" title=""><img src="https://cytotronics.com/wp-content/uploads/2024/10/MDA-MB-231-2-d4.webp" class="video_lightbox_anchor_image" alt="" /></a> <script type="rocketlazyloadscript"> /* <![CDATA[ */ jQuery(document).ready(function($){ $(function(){ var width = $(window).innerWidth(); var setwidth = parseFloat(640); var ratio = parseFloat(0.75); var height = parseFloat(480); var link = 'https://vimeo.com/1022967407?width=640&height=480'; if(width < setwidth) { height = Math.floor(width * 0.75); //console.log("device width "+width+", set width "+640+", ratio "+0.75+", new height "+ height); var new_url = wpvl_paramReplace('width', link, width); var new_url = wpvl_paramReplace('height', new_url, height); $("a#674ad84a66fe5").attr('href', new_url); //console.log(new_url); } }); }); /* ]]> */ </script></div></section> <div class='av-special-heading av-30ixet-91e85eaf73fd4b1ffaf67a47ab27f3f4 av-special-heading-h3 blockquote modern-quote avia-builder-el-25 el_after_av_codeblock el_before_av_textblock '><h3 class='av-special-heading-tag' itemprop="headline" >Motility</h3><div class="special-heading-border"><div class="special-heading-inner-border"></div></div></div> <section class='av_textblock_section av-2x1v3h-d9cb113c68a5fc503e06259fac819b63 ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><p style="text-align: left;">Motility is a tightly regulated cellular property that forms the crux of an array of physiological processes. Pixel allows continuous monitoring of single cells with no loss in time resolution during scale up. Here, metastatic breast cancer cells show long range motion over 48 hours of imaging.</p> </div></section></div><div class='av-flex-placeholder'></div><div class='flex_column av-2oi5xp-52f8a58b74435c3d07fecfcb807f9573 av_one_third avia-builder-el-27 el_after_av_one_third avia-builder-el-last flex_column_table_cell av-equal-height-column av-align-top av-animated-generic fade-in ' ><section class="avia_codeblock_section avia_code_block_2" itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_codeblock cell-death-video' itemprop="text" ><a id="674ad84a67102" rel="wp-video-lightbox" href="https://vimeo.com/1022965847?width=640&height=480" title=""><img src="https://cytotronics.com/wp-content/uploads/2024/10/A549-d4.webp" class="video_lightbox_anchor_image" alt="" /></a> <script type="rocketlazyloadscript"> /* <![CDATA[ */ jQuery(document).ready(function($){ $(function(){ var width = $(window).innerWidth(); var setwidth = parseFloat(640); var ratio = parseFloat(0.75); var height = parseFloat(480); var link = 'https://vimeo.com/1022965847?width=640&height=480'; if(width < setwidth) { height = Math.floor(width * 0.75); //console.log("device width "+width+", set width "+640+", ratio "+0.75+", new height "+ height); var new_url = wpvl_paramReplace('width', link, width); var new_url = wpvl_paramReplace('height', new_url, height); $("a#674ad84a67102").attr('href', new_url); //console.log(new_url); } }); }); /* ]]> */ </script></div></section> <div class='av-special-heading av-2c4o4l-88e4c21ead8ea72f13f20c1eb78cd8f5 av-special-heading-h3 blockquote modern-quote avia-builder-el-29 el_after_av_codeblock el_before_av_textblock '><h3 class='av-special-heading-tag' itemprop="headline" >Cell death</h3><div class="special-heading-border"><div class="special-heading-inner-border"></div></div></div> <section class='av_textblock_section av-26zmv1-2a335c3a6400848e5972b837be4f1b27 ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><p style="text-align: left;">Visualize cell death at single cell-resolution. Compare cellular phenotypes between responders and non-responders in the population. Here A549 cells were treated with DMSO or Doxorubicin to observe cell death real-time.</p> </div></section></div></div> </div></div></div></div></div><div id='av_section_4' class='avia-section av-12tkzp-071228798a40b01591a2e03d341d6d46 main_color avia-section-large avia-no-border-styling avia-builder-el-31 el_after_av_section el_before_av_section unset-row bottom-border avia-bg-style-scroll container_wrap fullsize' ><div class='container av-section-cont-open' ><div class='template-page content av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-637'><div class='entry-content-wrapper clearfix'> <div class='flex_column av-yqxo5-1850701fc67000da238108f890f076f7 av_one_full avia-builder-el-32 el_before_av_one_full avia-builder-el-first first flex_column_div av-animated-generic fade-in ' ><section class='av_textblock_section av-tl2b9-d1746630d4bf4513364559135b031280 ' itemscope="itemscope" itemtype="https://schema.org/CreativeWork" ><div class='avia_textblock' itemprop="text" ><h2>Data analytics</h2> <p>Real-time videos and recordings are uploaded to our cloud-based Pixel Pro software which includes feature extraction, population analysis, and tunable bio-basis parameter outputs. We can also collaborate with you to develop custom data analytics for specific biological questions.</p> </div></section></div><div class='flex_column av-nfs9h-c7822b6176a9b49f7299b93e69ae3df3 av_one_full avia-builder-el-34 el_after_av_one_full avia-builder-el-last first flex_column_div av-animated-generic fade-in column-top-margin' ><style type="text/css" data-created_by="avia_inline_auto" id="style-css-av-19rv9-97af231c07caae4a2d0a3e1b0b0cc0f8"> .avia-image-container.av-19rv9-97af231c07caae4a2d0a3e1b0b0cc0f8 img.avia_image{ box-shadow:none; } .avia-image-container.av-19rv9-97af231c07caae4a2d0a3e1b0b0cc0f8 .av-image-caption-overlay-center{ color:#ffffff; } </style> <div class='avia-image-container av-19rv9-97af231c07caae4a2d0a3e1b0b0cc0f8 av-styling- avia-align-center avia-builder-el-35 el_before_av_image avia-builder-el-first av-small-hide av-mini-hide' itemprop="image" itemscope="itemscope" itemtype="https://schema.org/ImageObject" ><div class="avia-image-container-inner"><div 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