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NK Cell Therapies and Their Promising Possibilities

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Development</a> </div> </div> <div class="subnav-item"> <div class="subnav-item-content"> <a href="/nextgen-biomed">NextGen Biomed</a> </div> </div> </div> </div> </li> </ul> </div> <div class="flex flex-align-center hide-sm show-md show-lg show-xl"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});" class="navbar-button">Contact</a> </div> </div> </header></div> <main id="main-content"> <div class="resource-single"> <div class="header bg-primary-light"> <div class="container-wrapper"> <div class="wide-container header-container"> <div class="header-content flex-1"> <div class="heading-smallcaps"> Drug Discovery &amp; Development | Industry Spotlights &amp; Insight Articles </div> <h1 class="heading"> NK Cell Therapies and Their Promising Possibilities </h1> <div class="byline"> Edited by Tom Cohen | 20 April 2023 </div> <div class="abstract"> Considering the potential of natural killer (NK) cells as immunotherapies for cancer treatment and the various methods being utilised to overcome cancer cells' resistance to NK cells. </div> </div> <div class="header-graphic flex-1"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Immuno/Tom-Did-You-Know-Industry-Spotlight-Template.jpg" class="header-graphic-image"> </div> </div> </div> </div> <div class="container-wrapper"> <div class="wide-container"> <div class="content"> <div class="content-body text-gap"> <!-- wp:paragraph --> <p>As we gear up for our <a href="https://oxfordglobal.com/natural-killer-cell-symposium/" target="_blank" rel="noreferrer noopener">NK Cell Symposium</a> next month, let’s dive into some of the ins and outs of the methods that have utilised NK cells for innovative and unique immunotherapies.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>The NK cell is an immune effector cell that plays a specialised role in the immune system. Their function is critical to the body’s ability to fight viruses and cancer.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Like their cytotoxic T cell cousins, NK’s function in the immune system is to recognise and kill infected cells. These killers’ role is unique in that they do not require activation to kill cells without a major histocompatibility complex (MHC) class I marker, owing to their name as “natural killers”.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>NK cells have proved useful to researchers who seek to exploit them as therapeutics. Autologous NK cell therapy involves taking NK cells from a patient’s own blood, expanding them in a lab, and infusing them back into the patient’s blood.</p> <!-- /wp:paragraph --> <!-- wp:list --> <ul><!-- wp:list-item --> <li><a href="https://oxfordglobal.com/immuno/resources/inkt-cells-and-their-applications-in-immuno-oncology/" target="_blank" rel="noreferrer noopener">iNKT Cells and Their Applications in Immuno-Oncology</a></li> <!-- /wp:list-item --> <!-- wp:list-item --> <li><a href="https://oxfordglobal.com/immuno/resources/targeting-solid-tumours-with-tcr-guided-nk-cells/" target="_blank" rel="noreferrer noopener">Targeting Solid Tumours With TCR Guided NK Cells</a></li> <!-- /wp:list-item --> <!-- wp:list-item --> <li><a href="https://oxfordglobal.com/immuno/resources/therapy-in-the-spotlight-car-t-cell-therapy-significant-approvals-and-regulatory-concerns/" target="_blank" rel="noreferrer noopener">Therapy In the Spotlight: CAR T Cell Therapy—Significant Approvals and Regulatory Concerns</a></li> <!-- /wp:list-item --></ul> <!-- /wp:list --> <!-- wp:paragraph --> <p></p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Although the autologous approach has proved successful in some cancer patients, tumour evasion of the immune response can present a challenge for the treatment. Cancer cells can evolve to downregulate the expression of NK-activating receptors and avoid being killed.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Other forms of immunotherapy seek to overcome the resistance of cancer cells to NKs. For example, by stimulating NK cells in a patients’ blood, they can be activated so that they are equipped to kill resistant cancer cells.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Furthermore, the chimeric antigen receptor (CAR) concept, which is best known to be applied in T cells, has recently also been applied to NK cells as well. Researchers are excited by this prospect because it would provide an allogenic and off-the-shelf form of NK cell therapy for cancer.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>There are still many challenges to overcome in the field and plenty more research to do. But the hope is that these unique immune cells could unlock fresh treatments for persistent diseases.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p><em>See the upcoming events in Oxford Global’s Immuno series&nbsp;<a href="https://oxfordglobal.com/immuno/upcoming/">here</a>.</em></p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p><em>Get your weekly dose of industry news<a href="https://oxfordglobal.com/immuno/hub/?jsf=jet-engine&amp;tax=resource_formats:322" target="_blank" rel="noreferrer noopener">?here</a></em><em>?and keep up to date with the latest</em><em>?</em><em>‘Industry Spotlight</em><em>’ posts.</em><em>?For other Immuno content, please visit the</em><em>?<a href="https://oxfordglobal.com/immuno/" target="_blank" rel="noreferrer noopener">Immuno Content Portal.</a></em></p> <!-- /wp:paragraph --> <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/nextgen-biomed/resources/fda-grant-rare-pediatric-disease-designation-to-omeross-antibody-for-c3-glomerulopathy"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/NextGen%20Biomed/FDA%20Grant%20Rare%20Pediatric%20Disease%20Designation%20to%20Omeros%E2%80%99s%20Antibody%20for%20C3%20Glomerulopathy.jpg" class="cover-graphic-image"> </div> </a><div class="content"><a href="/nextgen-biomed/resources/fda-grant-rare-pediatric-disease-designation-to-omeross-antibody-for-c3-glomerulopathy"> <h4> FDA Grant Rare Pediatric Disease Designation to Omeros’s Antibody for C3 Glomerulopathy </h4> <div class="abstract"> Rare pediatric disease designation allows the company to access priority review from the FDA for a new drug application or biologics licence application. </div> <div class="read-more"> <a href="/nextgen-biomed/resources/fda-grant-rare-pediatric-disease-designation-to-omeross-antibody-for-c3-glomerulopathy" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/nextgen-biomed/resources/regenerons-bispecific-gets-eu-approval-after-fda-rejection"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Immuno/Regeneron%E2%80%99s%20Bispecific%20Gets%20EU%20Approval%20After%20FDA%20Rejection.jpg" class="cover-graphic-image"> </div> </a><div class="content"><a href="/nextgen-biomed/resources/regenerons-bispecific-gets-eu-approval-after-fda-rejection"> <h4> Regeneron’s Bispecific Gets EU Approval After FDA Rejection </h4> <div class="abstract"> The approval means that the bispecific antibody odronextamab can be used to treat adult patients with relapsed or refractory follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) in the EU. </div> <div class="read-more"> <a href="/nextgen-biomed/resources/regenerons-bispecific-gets-eu-approval-after-fda-rejection" class="read-more-link">Read More</a> </div></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things NextGen Biomed </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177053686099">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery &amp; 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