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100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Frank Oppenheim</h3></div><div class="js-work-strip profile--work_container" data-work-id="110772521"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110772521/Use_of_Colorimetric_Test_Strips_for_Monitoring_the_Effect_of_Hemodialysis_on_Salivary_Nitrite_and_Uric_Acid_in_Patients_with_End_Stage_Renal_Disease_A_Proof_of_Principle"><img alt="Research paper thumbnail of Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle" class="work-thumbnail" src="https://attachments.academia-assets.com/108486654/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110772521/Use_of_Colorimetric_Test_Strips_for_Monitoring_the_Effect_of_Hemodialysis_on_Salivary_Nitrite_and_Uric_Acid_in_Patients_with_End_Stage_Renal_Disease_A_Proof_of_Principle">Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle</a></div><div class="wp-workCard_item"><span>Clinical Chemistry</span><span>, Sep 1, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: Initial screening of potential biomarkers for monitoring dialysis was performed with ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: Initial screening of potential biomarkers for monitoring dialysis was performed with saliva samples collected from patients with end-stage renal disease (ESRD). A more thorough analysis of the most promising markers identified in the initial screening was conducted with saliva samples acquired at hourly intervals throughout dialysis to monitor analyte concentrations as dialysis progressed. We observed that salivary nitrite (NO 2 Ϫ) and uric acid (UA) concentrations consistently decreased as dialysis proceeded. METHODS: Solution-based colorimetric-detection chemistries for NO 2 Ϫ and UA were converted to a test strip format to produce a simple method for semiquantitatively measuring NO 2 Ϫ and UA concentrations in the clinic or at the patient's home. We assessed the test strips with saliva samples collected from both ESRD patients undergoing dialysis and healthy control volunteers to qualitatively monitor the effect of dialysis on salivary NO 2 Ϫ and UA. We used computer software to analyze digital images of the resulting test strip color intensities. RESULTS: Test strip measurements showed that mean salivary concentrations of NO 2 Ϫ and UA were decreased in ESRD patients by 86% and 39%, respectively, compared with 15% and 9% for time-matched controls. Comparison of test strip results with calibrated solution-based assays suggests that the test strips can semiquantitatively measure salivary concentrations of NO 2 Ϫ and UA. CONCLUSIONS: The colorimetric test strips monitored changes in salivary NO 2 Ϫ and UA concentrations that occurred in ESRD patients during dialysis. The test strips may prove useful for noninvasively evaluating dialysis progress and may also be useful for monitoring renal disease status.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f6b6453d82449e12273cbe5ca0c6ed8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108486654,"asset_id":110772521,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108486654/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110772521"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110772521"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110772521; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96746992"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96746992/Identification_of_Lys_Pro_Gln_as_a_Novel_Cleavage_Site_Specificity_of_Saliva_associated_Proteases"><img alt="Research paper thumbnail of Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases" class="work-thumbnail" src="https://attachments.academia-assets.com/98559804/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96746992/Identification_of_Lys_Pro_Gln_as_a_Novel_Cleavage_Site_Specificity_of_Saliva_associated_Proteases">Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases</a></div><div class="wp-workCard_item"><span>Journal of Biological Chemistry</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The nonsterile environment of the oral cavity facilitates substantial proteolytic processing, not...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The nonsterile environment of the oral cavity facilitates substantial proteolytic processing, not only of resident salivary proteins but also of dietary proteins. To gain insight into whole saliva enzymatic processes, the in vivo generated peptides in this oral fluid were subjected to nano-flow liquid chromatography electrospray ionization tandem mass spectrometry. The 182 peptides identified were predominantly derived from acidic and basic proline-rich proteins, statherin, and histatins. The proteolytic cleavages in the basic proline-rich proteins occurred preferentially after a Gln residue with predominant specificity for the tripeptide Xaa-Pro-Gln, where Xaa in the P 3 position was mostly represented by Lys. Using the synthetic substrates Lys-Pro-Gln-pNA and Gly-Gly-Gln-pNA, the overall K m values were determined to be 97 ؎ 7.7 and 611 ؎ 28 M, respectively, confirming glutamine endoprotease activity in whole saliva and the influence of the amino acids in positions P 2 and P 3 on protease recognition. The pH optimum of Lys-Pro-Gln-pNA hydrolysis was 7.0, and the activity was most effectively inhibited by antipain and 4-(2-aminoethyl) benzenesulfonyl fluoride, was metal ion-dependent, and not inhibited by cysteine protease inhibitors. A systematic evaluation of enzyme activities in various exocrine and nonexocrine contributors to whole saliva revealed that the glutamine endoprotease is derived from dental plaque and likely microbial in origin. The P 1 site being occupied by a Gln residue is a nonarchetype with respect to known proteases and indicates the presence of novel glutamine-specific endoprotease(s) in oral fluid.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2137bfc79e99e2f4d6e526b22fd8125c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98559804,"asset_id":96746992,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98559804/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96746992"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96746992"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96746992; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96746992]").text(description); $(".js-view-count[data-work-id=96746992]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96746992; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96746992']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2137bfc79e99e2f4d6e526b22fd8125c" } } $('.js-work-strip[data-work-id=96746992]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96746992,"title":"Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases","internal_url":"https://www.academia.edu/96746992/Identification_of_Lys_Pro_Gln_as_a_Novel_Cleavage_Site_Specificity_of_Saliva_associated_Proteases","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[{"id":98559804,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98559804/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/98559804/download_file","bulk_download_file_name":"Identification_of_Lys_Pro_Gln_as_a_Novel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98559804/pdf-libre.pdf?1676193583=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_Lys_Pro_Gln_as_a_Novel.pdf\u0026Expires=1740568978\u0026Signature=Fpv3S-pEvMAWQR0dknCzvY0RnPYwYVjKhqvIFAucoUPTWM5NVFHV1oP473a5Qdv20cJJG25O8fSGSg3kXwxZra47Rt5~l7BARKNlPAPnqP4OviDGdltokDnWtjUcwSQmjjuGorsa-it-aKnRGF0Nvc~1P0VCU5Ds0AMa7y5oT1RyR5lqW5ipWDmqY1SBMZuCUipP55k~yh9Irje0NIw2jW52YWjwRCkGdTryt324NcTsg0vpp-nXM8pdFMkL-RZTHrbHNbcKdbyFcW9KbqYYC0rkHZbm1VP-HQTLWD7yAvbd-oKzaND0aPj3m48TYlAjhujSw8KSKeJRgsRbn4BSuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84493551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84493551/Influence_of_Histatin_5_on_Candida_albicans_Mitochondrial_Protein_Expression_Assessed_by_Quantitative_Mass_Spectrometry"><img alt="Research paper thumbnail of Influence of Histatin 5 on Candida albicans Mitochondrial Protein Expression Assessed by Quantitative Mass Spectrometry" class="work-thumbnail" src="https://attachments.academia-assets.com/89497774/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84493551/Influence_of_Histatin_5_on_Candida_albicans_Mitochondrial_Protein_Expression_Assessed_by_Quantitative_Mass_Spectrometry">Influence of Histatin 5 on Candida albicans Mitochondrial Protein Expression Assessed by Quantitative Mass Spectrometry</a></div><div class="wp-workCard_item"><span>Journal of Proteome Research</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Individual aspects of the mode of action of histatin 5, a human salivary antifungal protein, have...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Individual aspects of the mode of action of histatin 5, a human salivary antifungal protein, have been partially elucidated, but the mechanism likely involves a complex set of events which have not been characterized. Previous evidence points toward histatin-induced alterations in mitochondrial function. The purpose of the present study was to verify and quantify changes in the mitochondrial proteome of C. albicans treated with histatin 5. Cell killing was determined by plating and differential protein expression levels in the mitochondrial samples were determined by quantitative proteomics approaches employing mTRAQ and ICAT labeling and Western blotting. Relative quantitation ratios were established for 144 different proteins. Up-regulated mitochondrial proteins were predominantly involved in genome maintenance and gene expression, whereas proteins that constitute the respiratory enzyme complexes were mostly down-regulated. The differential expression of ATP synthase gamma chain and elongation factor 1-alpha were confirmed by Western blotting by comparison to levels of cytochrome c which were unchanged upon histatin treatment. The mTRAQ and ICAT proteomics results suggest that key steps in the histatin 5 antifungal mechanism involve a bioenergetic collapse of C. albicans, caused essentially by a decrease in mitochondrial ATP synthesis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e62c5048f83152c2978fab0eeb7d072a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89497774,"asset_id":84493551,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89497774/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84493551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84493551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84493551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84493551]").text(description); $(".js-view-count[data-work-id=84493551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84493551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84493551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e62c5048f83152c2978fab0eeb7d072a" } } $('.js-work-strip[data-work-id=84493551]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84493551,"title":"Influence of Histatin 5 on Candida albicans Mitochondrial Protein Expression Assessed by Quantitative Mass Spectrometry","internal_url":"https://www.academia.edu/84493551/Influence_of_Histatin_5_on_Candida_albicans_Mitochondrial_Protein_Expression_Assessed_by_Quantitative_Mass_Spectrometry","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[{"id":89497774,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89497774/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/89497774/download_file","bulk_download_file_name":"Influence_of_Histatin_5_on_Candida_albic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89497774/ptpmcrender-libre.pdf?1660258963=\u0026response-content-disposition=attachment%3B+filename%3DInfluence_of_Histatin_5_on_Candida_albic.pdf\u0026Expires=1740568978\u0026Signature=endCpD6BItymP-vCgIHoTosmN1cGI9vBOIHRCllY7MBGEr5Z~rB2BNW3GumOJraE6nhU4SlohRhna206gz3uqVhoWOn5rDAqBVVH0BUc8FWxubA1dPEz4g-fc9s6JIiPsgfuZ8rMZuA4F-KnbcYQ5a8CNi42GB9vmahjpxlBzWX-svmbU808oeLHduQ4pFaer76ovx2a4hcWb9rQ~AwX6OpK0N1iAuTk4ewFiX~wHBrTtwpPEiVCJ85dp2RIC2dBfawnpwMhuXkWtRuikSDDl1AWjqTZX5SkOfWzVk2qpmEnYJa53xulpvwB1BSNVlCHwWktejp8~9MOYR0x6li7gA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79104754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79104754/Large_scale_phosphoproteome_of_human_whole_saliva_using_disulfide_thiol_interchange_covalent_chromatography_and_mass_spectrometry"><img alt="Research paper thumbnail of Large-scale phosphoproteome of human whole saliva using disulfide–thiol interchange covalent chromatography and mass spectrometry" class="work-thumbnail" src="https://attachments.academia-assets.com/85941264/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79104754/Large_scale_phosphoproteome_of_human_whole_saliva_using_disulfide_thiol_interchange_covalent_chromatography_and_mass_spectrometry">Large-scale phosphoproteome of human whole saliva using disulfide–thiol interchange covalent chromatography and mass spectrometry</a></div><div class="wp-workCard_item"><span>Analytical Biochemistry</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thus far only a handful of phosphoproteins with important biological functions have been identifi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thus far only a handful of phosphoproteins with important biological functions have been identified and characterized in oral fluids and these include some of the abundant protein constituents of saliva. Whole saliva (WS) samples were trypsin digested followed by chemical derivatization using dithiothreitol (DTT) of the phospho-serine/threonine containing peptides. The DTTphosphopeptides were enriched by covalent disulphide-thiol-interchange chromatography and analysis by nano-flow LC-ESI-MS/MS. The specificity of DTT chemical derivatization was evaluated separately under different base-catalyzed conditions with NaOH and Ba(OH) 2 , blocking cysteine residues by iodoacetamide and enzymatic O-deglycosylation prior to DTT reaction. Further analysis of WS samples which were subjected to either of these conditions provided supporting evidence for phosphoprotein identifications. The combined chemical strategies and mass spectrometric analyses identified 65 phosphoproteins in WS of which 28 were based on two or more peptide identification criteria with high confidence, and 37 were based on a single phosphopeptide identification. Most of the identified proteins, ~80%, were hitherto unknown phosphoprotein components. This study represents the first large-scale documentation of phosphoproteins of WS. The origins and identity of WS phosphoproteome suggest significant implications for both basic science and the development of novel biomarkers/diagnostic tools for both systemic and oral disease states.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ba830c07120508407f03ba103d669ef1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85941264,"asset_id":79104754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85941264/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79104754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79104754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79104754; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79104754]").text(description); $(".js-view-count[data-work-id=79104754]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79104754; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79104754']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="58474697"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/58474697/Commensal_Bacterium_Rothia_aeria_Degrades_and_Detoxifies_Gluten_via_a_Highly_Effective_Subtilisin_Enzyme"><img alt="Research paper thumbnail of Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme" class="work-thumbnail" src="https://attachments.academia-assets.com/72867745/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/58474697/Commensal_Bacterium_Rothia_aeria_Degrades_and_Detoxifies_Gluten_via_a_Highly_Effective_Subtilisin_Enzyme">Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme</a></div><div class="wp-workCard_item"><span>Nutrients</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat, barley, and rye. Rothia aeria, a gram-positive natural colonizer of the oral cavity and the upper digestive tract is able to degrade and detoxify gluten in vitro. The objective of this study was to assess gluten-degrading activity of live and dead R. aeria bacteria in vitro, and to isolate the R. aeria gluten-degrading enzyme. Methods: After an overnight fast, Balb/c mouse were fed a 1 g pellet of standard chow containing 50% wheat (and 4% gliadin) with or without 1.6 × 107 live R. aeria bacteria. After 2 h, in vivo gluten degradation was assessed in gastric contents by SDS-PAGE and immunoblotting, and immunogenic epitope neutralization was assessed with the R5 gliadin ELISA assay. R. aeria enzyme isolation and identification was accomplished by separating proteins in the bacterial cell homogenate by C18 chromatography followed by gliadin zymograp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3e5bfd3170181919779bb1e9938af692" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72867745,"asset_id":58474697,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72867745/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="58474697"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="58474697"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 58474697; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373392]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373392,"title":"Antifungal Formulation and Method of Preparation","internal_url":"https://www.academia.edu/52373392/Antifungal_Formulation_and_Method_of_Preparation","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373391"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52373391/Electron_Microscopic_Immunogold_Localization_of_Salivary_Mucins_MG1_and_MG2_in_Human_Submandibular_and_Sublingual_Glands"><img alt="Research paper thumbnail of Electron Microscopic Immunogold Localization of Salivary Mucins MG1 and MG2 in Human Submandibular and Sublingual Glands" class="work-thumbnail" src="https://attachments.academia-assets.com/69667449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52373391/Electron_Microscopic_Immunogold_Localization_of_Salivary_Mucins_MG1_and_MG2_in_Human_Submandibular_and_Sublingual_Glands">Electron Microscopic Immunogold Localization of Salivary Mucins MG1 and MG2 in Human Submandibular and Sublingual Glands</a></div><div class="wp-workCard_item"><span>The Journal of Histochemistry and Cytochemistry</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The human salivary mucins MG1 and MG2 are well characterized biochemically and functionally. Howe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The human salivary mucins MG1 and MG2 are well characterized biochemically and functionally. However, there is disagreement regarding their cellular and glandular sources. The aim of this study was to define the localization and distribution of these two mucins in human salivary glands using a postembedding immunogold labeling method. Normal salivary glands obtained at surgery were fixed in 3% paraformaldehyde-0.1% glutaraldehyde and embedded in Lowicryl K4M or LR Gold resin. Thin sections were labeled with rabbit antibodies to MG1 or to an N-terminal synthetic peptide of MG2, followed by gold-labeled goat anti-rabbit IgG. The granules of all mucous cells of the submandibular and sublingual glands were intensely reactive with anti-MG1. No reaction was detected in serous cells. With anti-MG2, the granules of both mucous and serous cells showed reactivity. The labeling was variable in both cell types, with mucous cells exhibiting a stronger reaction in some glands and serous cells in others. In serous granules, the electron-lucent regions were more reactive than the dense cores. Intercalated duct cells near the acini displayed both MG1 and MG2 reactivity in their apical granules. In addition, the basal and lateral membranes of intercalated duct cells were labeled with anti-MG2. These results confirm those of earlier studies on MG1 localization in mucous cells and suggest that MG2 is produced by both mucous and serous cells. They also indicate differences in protein expression patterns among salivary serous cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48e0b6bf654ebe7af9d18bdde37b06a3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69667449,"asset_id":52373391,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69667449/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373391"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373391"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373391; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373390/Uncovering_molecular_events_in_periodontitis"><img alt="Research paper thumbnail of Uncovering molecular events in periodontitis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373390/Uncovering_molecular_events_in_periodontitis">Uncovering molecular events in periodontitis</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373390; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373390]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373390,"title":"Uncovering molecular events in periodontitis","internal_url":"https://www.academia.edu/52373390/Uncovering_molecular_events_in_periodontitis","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52373389/Bacteroides_forsythus_hemagglutinin_is_inhibited_by_N_acetylneuraminyllactose"><img alt="Research paper thumbnail of Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose" class="work-thumbnail" src="https://attachments.academia-assets.com/69667454/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52373389/Bacteroides_forsythus_hemagglutinin_is_inhibited_by_N_acetylneuraminyllactose">Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose</a></div><div class="wp-workCard_item"><span>Oral Microbiology and Immunology</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bacteroides forsythus, which has been recognized as a pathogen associated with periodontitis, pro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bacteroides forsythus, which has been recognized as a pathogen associated with periodontitis, produces a hemagglutinin. The hemagglutinin was localized in the envelope of B. forsythus. The hemagglutinating activity was inhibited by lactose at concentrations as low as 1 mM, and by -arginine and -lysine at concentrations of 100 mM. N-Acetylneuraminyllactose (NeuAc-lactose) was at least 100 times more potent an inhibitor than lactose, as it completely inhibited the</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fb74191168566aa032a8cca8324ef06a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69667454,"asset_id":52373389,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69667454/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373389; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52373388/Localization_of_the_genes_for_histatins_to_human_chromosome_4q13_and_tissue_distribution_of_the_mRNAs"><img alt="Research paper thumbnail of Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs" class="work-thumbnail" src="https://attachments.academia-assets.com/69667496/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52373388/Localization_of_the_genes_for_histatins_to_human_chromosome_4q13_and_tissue_distribution_of_the_mRNAs">Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs</a></div><div class="wp-workCard_item"><span>The American Journal of Human Genetics</span><span>, Sep 1, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A cDNA coding for histatin 1 was isolated from a human submandibular-gland library and sequenced....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A cDNA coding for histatin 1 was isolated from a human submandibular-gland library and sequenced. This cDNA was used to probe RNAs isolated from a variety of tissues to investigate tissue-specific regulation and to determine whether histatins might play a role other than in the oral cavity. The same probe was also used for Southern blot analysis of human genomic DNA restricted with various enzymes, and it showed that the genes coding for histatins are on the same chromosome. In situ hybridization of the cDNA probe to metaphase chromosome spreads was performed to determine chromosomal location of the genes for histatins. A genomic fragment isolated using the cDNA probe was also hybridized to chromosome spreads, and the same chromosome was identified. The genes for histatins are located on chromosome 4, band q13. We have shown that three histatin mRNAs are expressed in human parotid and submandibular glands but in none of the other tissues studied. 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373385]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373385,"title":"Antifungal and antibacterial peptides","internal_url":"https://www.academia.edu/52373385/Antifungal_and_antibacterial_peptides","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373384"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373384/Phosphoproteome_of_Human_Parotid_Saliva_by_Mass_Spectrometry"><img alt="Research paper thumbnail of Phosphoproteome of Human Parotid Saliva by Mass Spectrometry" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373384/Phosphoproteome_of_Human_Parotid_Saliva_by_Mass_Spectrometry">Phosphoproteome of Human Parotid Saliva by Mass Spectrometry</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Only a small number of phosphoproteins derived from parotid secretion have been identified and ch...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Only a small number of phosphoproteins derived from parotid secretion have been identified and characterized with important biological functions and these represent the abundant protein constituents. Their biological functions in the oral cavity as well as their structural ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373384"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373384"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373384; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373384]").text(description); $(".js-view-count[data-work-id=52373384]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373384; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373384']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373384]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373384,"title":"Phosphoproteome of Human Parotid Saliva by Mass Spectrometry","internal_url":"https://www.academia.edu/52373384/Phosphoproteome_of_Human_Parotid_Saliva_by_Mass_Spectrometry","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373383"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373383/Salivary_histatins_in_patients_with_recurrent_oral_candidiasis"><img alt="Research paper thumbnail of Salivary histatins in patients with recurrent oral candidiasis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373383/Salivary_histatins_in_patients_with_recurrent_oral_candidiasis">Salivary histatins in patients with recurrent oral candidiasis</a></div><div class="wp-workCard_item"><span>J Oral Pathol Med</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral can...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral candidiasis and in age-, sex-matched healthy controls. Salivary pH, flow rate, total protein and histatins were compared. Results of this study indicated that salivary pH was significantly lower among patients than controls (5.9 vs. 6.3, respectively, P = 0.002). No significant difference was observed in the mean flow rate and total protein between patients and controls (0.39 ml/min/gland vs. 0.46 ml/min/gland and 112.4 mg% vs. 113.0 mg%, respectively). However, the mean salivary histatin levels were significantly higher among patients than controls, both in terms of concentration (16.8 mg% vs. 11.1 mg%, P = 0.016) as well as a ratio of total protein (15 mg/g vs. 10 mg/g, P = 0.018). These findings indicate that oral candidiasis is associated with increased levels of salivary histatin. Such a finding suggests that oral candidiasis may modulate the levels of salivary histatin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373383"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373383"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373383; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373383]").text(description); $(".js-view-count[data-work-id=52373383]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373383; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373383']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373383]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373383,"title":"Salivary histatins in patients with recurrent oral candidiasis","internal_url":"https://www.academia.edu/52373383/Salivary_histatins_in_patients_with_recurrent_oral_candidiasis","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3834510" id="papers"><div class="js-work-strip profile--work_container" data-work-id="110772521"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110772521/Use_of_Colorimetric_Test_Strips_for_Monitoring_the_Effect_of_Hemodialysis_on_Salivary_Nitrite_and_Uric_Acid_in_Patients_with_End_Stage_Renal_Disease_A_Proof_of_Principle"><img alt="Research paper thumbnail of Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle" class="work-thumbnail" src="https://attachments.academia-assets.com/108486654/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110772521/Use_of_Colorimetric_Test_Strips_for_Monitoring_the_Effect_of_Hemodialysis_on_Salivary_Nitrite_and_Uric_Acid_in_Patients_with_End_Stage_Renal_Disease_A_Proof_of_Principle">Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle</a></div><div class="wp-workCard_item"><span>Clinical Chemistry</span><span>, Sep 1, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: Initial screening of potential biomarkers for monitoring dialysis was performed with ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: Initial screening of potential biomarkers for monitoring dialysis was performed with saliva samples collected from patients with end-stage renal disease (ESRD). A more thorough analysis of the most promising markers identified in the initial screening was conducted with saliva samples acquired at hourly intervals throughout dialysis to monitor analyte concentrations as dialysis progressed. We observed that salivary nitrite (NO 2 Ϫ) and uric acid (UA) concentrations consistently decreased as dialysis proceeded. METHODS: Solution-based colorimetric-detection chemistries for NO 2 Ϫ and UA were converted to a test strip format to produce a simple method for semiquantitatively measuring NO 2 Ϫ and UA concentrations in the clinic or at the patient's home. We assessed the test strips with saliva samples collected from both ESRD patients undergoing dialysis and healthy control volunteers to qualitatively monitor the effect of dialysis on salivary NO 2 Ϫ and UA. We used computer software to analyze digital images of the resulting test strip color intensities. RESULTS: Test strip measurements showed that mean salivary concentrations of NO 2 Ϫ and UA were decreased in ESRD patients by 86% and 39%, respectively, compared with 15% and 9% for time-matched controls. Comparison of test strip results with calibrated solution-based assays suggests that the test strips can semiquantitatively measure salivary concentrations of NO 2 Ϫ and UA. CONCLUSIONS: The colorimetric test strips monitored changes in salivary NO 2 Ϫ and UA concentrations that occurred in ESRD patients during dialysis. The test strips may prove useful for noninvasively evaluating dialysis progress and may also be useful for monitoring renal disease status.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f6b6453d82449e12273cbe5ca0c6ed8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108486654,"asset_id":110772521,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108486654/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110772521"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110772521"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110772521; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110772521]").text(description); $(".js-view-count[data-work-id=110772521]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110772521; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110772521']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f6b6453d82449e12273cbe5ca0c6ed8" } } $('.js-work-strip[data-work-id=110772521]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110772521,"title":"Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle","internal_url":"https://www.academia.edu/110772521/Use_of_Colorimetric_Test_Strips_for_Monitoring_the_Effect_of_Hemodialysis_on_Salivary_Nitrite_and_Uric_Acid_in_Patients_with_End_Stage_Renal_Disease_A_Proof_of_Principle","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[{"id":108486654,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108486654/thumbnails/1.jpg","file_name":"clinchem1473.pdf","download_url":"https://www.academia.edu/attachments/108486654/download_file","bulk_download_file_name":"Use_of_Colorimetric_Test_Strips_for_Moni.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108486654/clinchem1473-libre.pdf?1701932932=\u0026response-content-disposition=attachment%3B+filename%3DUse_of_Colorimetric_Test_Strips_for_Moni.pdf\u0026Expires=1740568978\u0026Signature=O6aWgwQgFGotY5yyqA98Z1Kv5naJom-KN-8WCBzJAUstAb6464Mv6VjVTUkmpAtoHYBoP9n3TjxLNs1U9ThpOOVoEmxRvy2K6uFP0cHvWGQJldXS2lPOpoPJaAXej3w3aiaeJ2iLnYrBKOX76sltE9coi1-129lEhfpTi3kHfn7rsW7DBLXbcRFvIIVeQPmYDaVNBs0j6p9TRPxbosGx8hqezLTz4SQixulCTsOS8PQ9CYdvghkEmoBwgS26Ie1L85S6ekiCnNfssuERE4O0GMVJbf4HRj3bAM7lwYZ27WrkEuL0isZrEhDAMNxsAmR2s0zGy7syBiG-EpSkQvZffA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96746992"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96746992/Identification_of_Lys_Pro_Gln_as_a_Novel_Cleavage_Site_Specificity_of_Saliva_associated_Proteases"><img alt="Research paper thumbnail of Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases" class="work-thumbnail" src="https://attachments.academia-assets.com/98559804/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96746992/Identification_of_Lys_Pro_Gln_as_a_Novel_Cleavage_Site_Specificity_of_Saliva_associated_Proteases">Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases</a></div><div class="wp-workCard_item"><span>Journal of Biological Chemistry</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The nonsterile environment of the oral cavity facilitates substantial proteolytic processing, not...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The nonsterile environment of the oral cavity facilitates substantial proteolytic processing, not only of resident salivary proteins but also of dietary proteins. To gain insight into whole saliva enzymatic processes, the in vivo generated peptides in this oral fluid were subjected to nano-flow liquid chromatography electrospray ionization tandem mass spectrometry. The 182 peptides identified were predominantly derived from acidic and basic proline-rich proteins, statherin, and histatins. The proteolytic cleavages in the basic proline-rich proteins occurred preferentially after a Gln residue with predominant specificity for the tripeptide Xaa-Pro-Gln, where Xaa in the P 3 position was mostly represented by Lys. Using the synthetic substrates Lys-Pro-Gln-pNA and Gly-Gly-Gln-pNA, the overall K m values were determined to be 97 ؎ 7.7 and 611 ؎ 28 M, respectively, confirming glutamine endoprotease activity in whole saliva and the influence of the amino acids in positions P 2 and P 3 on protease recognition. The pH optimum of Lys-Pro-Gln-pNA hydrolysis was 7.0, and the activity was most effectively inhibited by antipain and 4-(2-aminoethyl) benzenesulfonyl fluoride, was metal ion-dependent, and not inhibited by cysteine protease inhibitors. A systematic evaluation of enzyme activities in various exocrine and nonexocrine contributors to whole saliva revealed that the glutamine endoprotease is derived from dental plaque and likely microbial in origin. The P 1 site being occupied by a Gln residue is a nonarchetype with respect to known proteases and indicates the presence of novel glutamine-specific endoprotease(s) in oral fluid.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2137bfc79e99e2f4d6e526b22fd8125c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98559804,"asset_id":96746992,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98559804/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96746992"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96746992"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96746992; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96746992]").text(description); $(".js-view-count[data-work-id=96746992]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96746992; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96746992']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2137bfc79e99e2f4d6e526b22fd8125c" } } $('.js-work-strip[data-work-id=96746992]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96746992,"title":"Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases","internal_url":"https://www.academia.edu/96746992/Identification_of_Lys_Pro_Gln_as_a_Novel_Cleavage_Site_Specificity_of_Saliva_associated_Proteases","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[{"id":98559804,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98559804/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/98559804/download_file","bulk_download_file_name":"Identification_of_Lys_Pro_Gln_as_a_Novel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98559804/pdf-libre.pdf?1676193583=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_Lys_Pro_Gln_as_a_Novel.pdf\u0026Expires=1740568978\u0026Signature=Fpv3S-pEvMAWQR0dknCzvY0RnPYwYVjKhqvIFAucoUPTWM5NVFHV1oP473a5Qdv20cJJG25O8fSGSg3kXwxZra47Rt5~l7BARKNlPAPnqP4OviDGdltokDnWtjUcwSQmjjuGorsa-it-aKnRGF0Nvc~1P0VCU5Ds0AMa7y5oT1RyR5lqW5ipWDmqY1SBMZuCUipP55k~yh9Irje0NIw2jW52YWjwRCkGdTryt324NcTsg0vpp-nXM8pdFMkL-RZTHrbHNbcKdbyFcW9KbqYYC0rkHZbm1VP-HQTLWD7yAvbd-oKzaND0aPj3m48TYlAjhujSw8KSKeJRgsRbn4BSuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84493551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84493551/Influence_of_Histatin_5_on_Candida_albicans_Mitochondrial_Protein_Expression_Assessed_by_Quantitative_Mass_Spectrometry"><img alt="Research paper thumbnail of Influence of Histatin 5 on Candida albicans Mitochondrial Protein Expression Assessed by Quantitative Mass Spectrometry" class="work-thumbnail" src="https://attachments.academia-assets.com/89497774/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84493551/Influence_of_Histatin_5_on_Candida_albicans_Mitochondrial_Protein_Expression_Assessed_by_Quantitative_Mass_Spectrometry">Influence of Histatin 5 on Candida albicans Mitochondrial Protein Expression Assessed by Quantitative Mass Spectrometry</a></div><div class="wp-workCard_item"><span>Journal of Proteome Research</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Individual aspects of the mode of action of histatin 5, a human salivary antifungal protein, have...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Individual aspects of the mode of action of histatin 5, a human salivary antifungal protein, have been partially elucidated, but the mechanism likely involves a complex set of events which have not been characterized. Previous evidence points toward histatin-induced alterations in mitochondrial function. The purpose of the present study was to verify and quantify changes in the mitochondrial proteome of C. albicans treated with histatin 5. Cell killing was determined by plating and differential protein expression levels in the mitochondrial samples were determined by quantitative proteomics approaches employing mTRAQ and ICAT labeling and Western blotting. Relative quantitation ratios were established for 144 different proteins. Up-regulated mitochondrial proteins were predominantly involved in genome maintenance and gene expression, whereas proteins that constitute the respiratory enzyme complexes were mostly down-regulated. The differential expression of ATP synthase gamma chain and elongation factor 1-alpha were confirmed by Western blotting by comparison to levels of cytochrome c which were unchanged upon histatin treatment. The mTRAQ and ICAT proteomics results suggest that key steps in the histatin 5 antifungal mechanism involve a bioenergetic collapse of C. albicans, caused essentially by a decrease in mitochondrial ATP synthesis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e62c5048f83152c2978fab0eeb7d072a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89497774,"asset_id":84493551,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89497774/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84493551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84493551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84493551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84493551]").text(description); $(".js-view-count[data-work-id=84493551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84493551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84493551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79104754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79104754/Large_scale_phosphoproteome_of_human_whole_saliva_using_disulfide_thiol_interchange_covalent_chromatography_and_mass_spectrometry"><img alt="Research paper thumbnail of Large-scale phosphoproteome of human whole saliva using disulfide–thiol interchange covalent chromatography and mass spectrometry" class="work-thumbnail" src="https://attachments.academia-assets.com/85941264/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79104754/Large_scale_phosphoproteome_of_human_whole_saliva_using_disulfide_thiol_interchange_covalent_chromatography_and_mass_spectrometry">Large-scale phosphoproteome of human whole saliva using disulfide–thiol interchange covalent chromatography and mass spectrometry</a></div><div class="wp-workCard_item"><span>Analytical Biochemistry</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thus far only a handful of phosphoproteins with important biological functions have been identifi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thus far only a handful of phosphoproteins with important biological functions have been identified and characterized in oral fluids and these include some of the abundant protein constituents of saliva. Whole saliva (WS) samples were trypsin digested followed by chemical derivatization using dithiothreitol (DTT) of the phospho-serine/threonine containing peptides. The DTTphosphopeptides were enriched by covalent disulphide-thiol-interchange chromatography and analysis by nano-flow LC-ESI-MS/MS. The specificity of DTT chemical derivatization was evaluated separately under different base-catalyzed conditions with NaOH and Ba(OH) 2 , blocking cysteine residues by iodoacetamide and enzymatic O-deglycosylation prior to DTT reaction. Further analysis of WS samples which were subjected to either of these conditions provided supporting evidence for phosphoprotein identifications. The combined chemical strategies and mass spectrometric analyses identified 65 phosphoproteins in WS of which 28 were based on two or more peptide identification criteria with high confidence, and 37 were based on a single phosphopeptide identification. Most of the identified proteins, ~80%, were hitherto unknown phosphoprotein components. This study represents the first large-scale documentation of phosphoproteins of WS. The origins and identity of WS phosphoproteome suggest significant implications for both basic science and the development of novel biomarkers/diagnostic tools for both systemic and oral disease states.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ba830c07120508407f03ba103d669ef1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85941264,"asset_id":79104754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85941264/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79104754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79104754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79104754; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79104754]").text(description); $(".js-view-count[data-work-id=79104754]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79104754; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79104754']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ba830c07120508407f03ba103d669ef1" } } $('.js-work-strip[data-work-id=79104754]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79104754,"title":"Large-scale phosphoproteome of human whole saliva using disulfide–thiol interchange covalent chromatography and mass spectrometry","internal_url":"https://www.academia.edu/79104754/Large_scale_phosphoproteome_of_human_whole_saliva_using_disulfide_thiol_interchange_covalent_chromatography_and_mass_spectrometry","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[{"id":85941264,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85941264/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/85941264/download_file","bulk_download_file_name":"Large_scale_phosphoproteome_of_human_who.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85941264/pdf-libre.pdf?1652641915=\u0026response-content-disposition=attachment%3B+filename%3DLarge_scale_phosphoproteome_of_human_who.pdf\u0026Expires=1740568978\u0026Signature=FpozpGxM9Jw3LaKNT6eIbklg~wHoFZMPLqPRMRBljEJR6r8BnERyKNmMgDniEew53saIRiobgjrpv9RPUPFAq29XtgARgAVRpggTcPpfNeVHDdQRLELuaqOhOts29cieR3FTyJXedYiQD~jgeyxCzzm8V7Ksh0iyBsTg35iYAkoBcTmT7QVL7adKAc2JqFbs2NCwLL74v6hlUREGHWqo5EBxgun2yw9jkhuEUeJ9NYfoKATgH~04ZYoejo5AfYk4lw~i8KUUjKCLQ6ShIBykezjWrlQm2lJbiuJFrrNp4~6rtdQvmUKWJHkiSeP9uuoCTc~sBEz7KBzt6kBC3zQ8SQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="58474697"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/58474697/Commensal_Bacterium_Rothia_aeria_Degrades_and_Detoxifies_Gluten_via_a_Highly_Effective_Subtilisin_Enzyme"><img alt="Research paper thumbnail of Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme" class="work-thumbnail" src="https://attachments.academia-assets.com/72867745/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/58474697/Commensal_Bacterium_Rothia_aeria_Degrades_and_Detoxifies_Gluten_via_a_Highly_Effective_Subtilisin_Enzyme">Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme</a></div><div class="wp-workCard_item"><span>Nutrients</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat, barley, and rye. Rothia aeria, a gram-positive natural colonizer of the oral cavity and the upper digestive tract is able to degrade and detoxify gluten in vitro. The objective of this study was to assess gluten-degrading activity of live and dead R. aeria bacteria in vitro, and to isolate the R. aeria gluten-degrading enzyme. Methods: After an overnight fast, Balb/c mouse were fed a 1 g pellet of standard chow containing 50% wheat (and 4% gliadin) with or without 1.6 × 107 live R. aeria bacteria. After 2 h, in vivo gluten degradation was assessed in gastric contents by SDS-PAGE and immunoblotting, and immunogenic epitope neutralization was assessed with the R5 gliadin ELISA assay. R. aeria enzyme isolation and identification was accomplished by separating proteins in the bacterial cell homogenate by C18 chromatography followed by gliadin zymograp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3e5bfd3170181919779bb1e9938af692" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72867745,"asset_id":58474697,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72867745/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="58474697"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="58474697"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 58474697; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373392]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373392,"title":"Antifungal Formulation and Method of Preparation","internal_url":"https://www.academia.edu/52373392/Antifungal_Formulation_and_Method_of_Preparation","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373391"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52373391/Electron_Microscopic_Immunogold_Localization_of_Salivary_Mucins_MG1_and_MG2_in_Human_Submandibular_and_Sublingual_Glands"><img alt="Research paper thumbnail of Electron Microscopic Immunogold Localization of Salivary Mucins MG1 and MG2 in Human Submandibular and Sublingual Glands" class="work-thumbnail" src="https://attachments.academia-assets.com/69667449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52373391/Electron_Microscopic_Immunogold_Localization_of_Salivary_Mucins_MG1_and_MG2_in_Human_Submandibular_and_Sublingual_Glands">Electron Microscopic Immunogold Localization of Salivary Mucins MG1 and MG2 in Human Submandibular and Sublingual Glands</a></div><div class="wp-workCard_item"><span>The Journal of Histochemistry and Cytochemistry</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The human salivary mucins MG1 and MG2 are well characterized biochemically and functionally. Howe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The human salivary mucins MG1 and MG2 are well characterized biochemically and functionally. However, there is disagreement regarding their cellular and glandular sources. The aim of this study was to define the localization and distribution of these two mucins in human salivary glands using a postembedding immunogold labeling method. Normal salivary glands obtained at surgery were fixed in 3% paraformaldehyde-0.1% glutaraldehyde and embedded in Lowicryl K4M or LR Gold resin. Thin sections were labeled with rabbit antibodies to MG1 or to an N-terminal synthetic peptide of MG2, followed by gold-labeled goat anti-rabbit IgG. The granules of all mucous cells of the submandibular and sublingual glands were intensely reactive with anti-MG1. No reaction was detected in serous cells. With anti-MG2, the granules of both mucous and serous cells showed reactivity. The labeling was variable in both cell types, with mucous cells exhibiting a stronger reaction in some glands and serous cells in others. In serous granules, the electron-lucent regions were more reactive than the dense cores. Intercalated duct cells near the acini displayed both MG1 and MG2 reactivity in their apical granules. In addition, the basal and lateral membranes of intercalated duct cells were labeled with anti-MG2. These results confirm those of earlier studies on MG1 localization in mucous cells and suggest that MG2 is produced by both mucous and serous cells. 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373390]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373390,"title":"Uncovering molecular events in periodontitis","internal_url":"https://www.academia.edu/52373390/Uncovering_molecular_events_in_periodontitis","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52373389/Bacteroides_forsythus_hemagglutinin_is_inhibited_by_N_acetylneuraminyllactose"><img alt="Research paper thumbnail of Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose" class="work-thumbnail" src="https://attachments.academia-assets.com/69667454/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52373389/Bacteroides_forsythus_hemagglutinin_is_inhibited_by_N_acetylneuraminyllactose">Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose</a></div><div class="wp-workCard_item"><span>Oral Microbiology and Immunology</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bacteroides forsythus, which has been recognized as a pathogen associated with periodontitis, pro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bacteroides forsythus, which has been recognized as a pathogen associated with periodontitis, produces a hemagglutinin. The hemagglutinin was localized in the envelope of B. forsythus. The hemagglutinating activity was inhibited by lactose at concentrations as low as 1 mM, and by -arginine and -lysine at concentrations of 100 mM. N-Acetylneuraminyllactose (NeuAc-lactose) was at least 100 times more potent an inhibitor than lactose, as it completely inhibited the</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fb74191168566aa032a8cca8324ef06a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69667454,"asset_id":52373389,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69667454/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373389; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373389]").text(description); $(".js-view-count[data-work-id=52373389]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373389; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373389']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52373388/Localization_of_the_genes_for_histatins_to_human_chromosome_4q13_and_tissue_distribution_of_the_mRNAs"><img alt="Research paper thumbnail of Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs" class="work-thumbnail" src="https://attachments.academia-assets.com/69667496/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52373388/Localization_of_the_genes_for_histatins_to_human_chromosome_4q13_and_tissue_distribution_of_the_mRNAs">Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs</a></div><div class="wp-workCard_item"><span>The American Journal of Human Genetics</span><span>, Sep 1, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A cDNA coding for histatin 1 was isolated from a human submandibular-gland library and sequenced....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A cDNA coding for histatin 1 was isolated from a human submandibular-gland library and sequenced. This cDNA was used to probe RNAs isolated from a variety of tissues to investigate tissue-specific regulation and to determine whether histatins might play a role other than in the oral cavity. The same probe was also used for Southern blot analysis of human genomic DNA restricted with various enzymes, and it showed that the genes coding for histatins are on the same chromosome. In situ hybridization of the cDNA probe to metaphase chromosome spreads was performed to determine chromosomal location of the genes for histatins. A genomic fragment isolated using the cDNA probe was also hybridized to chromosome spreads, and the same chromosome was identified. The genes for histatins are located on chromosome 4, band q13. We have shown that three histatin mRNAs are expressed in human parotid and submandibular glands but in none of the other tissues studied. These results suggest that histatins are specific to salivary secretions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aca8980345d1c15b2624f7ef2004a1e3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69667496,"asset_id":52373388,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69667496/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373388"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373388"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373388; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373388]").text(description); $(".js-view-count[data-work-id=52373388]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373388; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373388']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373387"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373387/Rothia_Species_Glutamine_Endopeptidases_and_Use_Thereof"><img alt="Research paper thumbnail of Rothia Species Glutamine Endopeptidases and Use Thereof" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373387/Rothia_Species_Glutamine_Endopeptidases_and_Use_Thereof">Rothia Species Glutamine Endopeptidases and Use Thereof</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373387; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373387,"title":"Rothia Species Glutamine Endopeptidases and Use Thereof","internal_url":"https://www.academia.edu/52373387/Rothia_Species_Glutamine_Endopeptidases_and_Use_Thereof","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373386"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373386/Anti_fungal_and_anti_bacterial_histatin_based_peptides"><img alt="Research paper thumbnail of Anti-fungal and anti-bacterial histatin-based peptides" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373386/Anti_fungal_and_anti_bacterial_histatin_based_peptides">Anti-fungal and anti-bacterial histatin-based peptides</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373386"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373386"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373386; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373386]").text(description); $(".js-view-count[data-work-id=52373386]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373386; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373386']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373386]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373386,"title":"Anti-fungal and anti-bacterial histatin-based peptides","internal_url":"https://www.academia.edu/52373386/Anti_fungal_and_anti_bacterial_histatin_based_peptides","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373385"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373385/Antifungal_and_antibacterial_peptides"><img alt="Research paper thumbnail of Antifungal and antibacterial peptides" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373385/Antifungal_and_antibacterial_peptides">Antifungal and antibacterial peptides</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373385"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373385"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373385; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373385]").text(description); $(".js-view-count[data-work-id=52373385]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373385; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373385']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373385]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373385,"title":"Antifungal and antibacterial peptides","internal_url":"https://www.academia.edu/52373385/Antifungal_and_antibacterial_peptides","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373384"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373384/Phosphoproteome_of_Human_Parotid_Saliva_by_Mass_Spectrometry"><img alt="Research paper thumbnail of Phosphoproteome of Human Parotid Saliva by Mass Spectrometry" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373384/Phosphoproteome_of_Human_Parotid_Saliva_by_Mass_Spectrometry">Phosphoproteome of Human Parotid Saliva by Mass Spectrometry</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Only a small number of phosphoproteins derived from parotid secretion have been identified and ch...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Only a small number of phosphoproteins derived from parotid secretion have been identified and characterized with important biological functions and these represent the abundant protein constituents. Their biological functions in the oral cavity as well as their structural ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373384"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373384"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373384; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373384]").text(description); $(".js-view-count[data-work-id=52373384]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373384; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373384']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373384]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373384,"title":"Phosphoproteome of Human Parotid Saliva by Mass Spectrometry","internal_url":"https://www.academia.edu/52373384/Phosphoproteome_of_Human_Parotid_Saliva_by_Mass_Spectrometry","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52373383"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52373383/Salivary_histatins_in_patients_with_recurrent_oral_candidiasis"><img alt="Research paper thumbnail of Salivary histatins in patients with recurrent oral candidiasis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52373383/Salivary_histatins_in_patients_with_recurrent_oral_candidiasis">Salivary histatins in patients with recurrent oral candidiasis</a></div><div class="wp-workCard_item"><span>J Oral Pathol Med</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral can...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral candidiasis and in age-, sex-matched healthy controls. Salivary pH, flow rate, total protein and histatins were compared. Results of this study indicated that salivary pH was significantly lower among patients than controls (5.9 vs. 6.3, respectively, P = 0.002). No significant difference was observed in the mean flow rate and total protein between patients and controls (0.39 ml/min/gland vs. 0.46 ml/min/gland and 112.4 mg% vs. 113.0 mg%, respectively). However, the mean salivary histatin levels were significantly higher among patients than controls, both in terms of concentration (16.8 mg% vs. 11.1 mg%, P = 0.016) as well as a ratio of total protein (15 mg/g vs. 10 mg/g, P = 0.018). These findings indicate that oral candidiasis is associated with increased levels of salivary histatin. Such a finding suggests that oral candidiasis may modulate the levels of salivary histatin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52373383"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52373383"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52373383; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52373383]").text(description); $(".js-view-count[data-work-id=52373383]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52373383; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52373383']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52373383]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52373383,"title":"Salivary histatins in patients with recurrent oral candidiasis","internal_url":"https://www.academia.edu/52373383/Salivary_histatins_in_patients_with_recurrent_oral_candidiasis","owner_id":36883293,"coauthors_can_edit":true,"owner":{"id":36883293,"first_name":"Frank","middle_initials":null,"last_name":"Oppenheim","page_name":"OppenheimFrank","domain_name":"independent","created_at":"2015-10-24T13:50:48.281-07:00","display_name":"Frank Oppenheim","url":"https://independent.academia.edu/OppenheimFrank"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); 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