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id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Početak</div> </a> </li> <li id="toc-Svojstva" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Svojstva"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Svojstva</span> </div> </a> <ul id="toc-Svojstva-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Sinteza_i_metabolizam" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Sinteza_i_metabolizam"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Sinteza i metabolizam</span> </div> </a> <ul id="toc-Sinteza_i_metabolizam-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Skladištenje_i_otpuštanje" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Skladištenje_i_otpuštanje"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Skladištenje i otpuštanje</span> </div> </a> <ul id="toc-Skladištenje_i_otpuštanje-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mehanizam_djelovanja" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mehanizam_djelovanja"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Mehanizam djelovanja</span> </div> </a> <button aria-controls="toc-Mehanizam_djelovanja-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Sadržaj cjeline Mehanizam djelovanja</span> </button> <ul id="toc-Mehanizam_djelovanja-sublist" class="vector-toc-list"> <li id="toc-Supresivni_efekti" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Supresivni_efekti"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Supresivni efekti</span> </div> </a> <ul id="toc-Supresivni_efekti-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Erekcija_i_uloga_u_seksu" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Erekcija_i_uloga_u_seksu"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Erekcija i uloga u seksu</span> </div> </a> <ul id="toc-Erekcija_i_uloga_u_seksu-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Shizofrenija" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Shizofrenija"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Shizofrenija</span> </div> </a> <ul id="toc-Shizofrenija-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Poremećaji" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Poremećaji"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Poremećaji</span> </div> </a> <ul id="toc-Poremećaji-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Izvori" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Izvori"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Izvori</span> </div> </a> <ul id="toc-Izvori-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prikaz sadržaja stranice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prikaz sadržaja stranice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Histamin</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Idi na druge jezične varijante članka. Dostupan je na 64 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-64" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">64 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%87%D8%B3%D8%AA%D8%A7%D9%85%D9%8A%D9%86" title="هستامين – arapski" lang="ar" hreflang="ar" data-title="هستامين" data-language-autonym="العربية" data-language-local-name="arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%87%DB%8C%D8%B3%D8%AA%D8%A7%D9%85%DB%8C%D9%86" title="هیستامین – South Azerbaijani" lang="azb" hreflang="azb" data-title="هیستامین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%93%D1%96%D1%81%D1%82%D0%B0%D0%BC%D1%96%D0%BD" title="Гістамін – bjeloruski" lang="be" hreflang="be" data-title="Гістамін" data-language-autonym="Беларуская" data-language-local-name="bjeloruski" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Хистамин – bugarski" lang="bg" hreflang="bg" data-title="Хистамин" data-language-autonym="Български" data-language-local-name="bugarski" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%B9%E0%A6%BF%E0%A6%B8%E0%A7%8D%E0%A6%9F%E0%A6%BE%E0%A6%AE%E0%A6%BF%E0%A6%A8" title="হিস্টামিন – bangla" lang="bn" hreflang="bn" data-title="হিস্টামিন" data-language-autonym="বাংলা" data-language-local-name="bangla" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Histamin" title="Histamin – bosanski" lang="bs" hreflang="bs" data-title="Histamin" data-language-autonym="Bosanski" data-language-local-name="bosanski" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Histamina" title="Histamina – katalonski" lang="ca" hreflang="ca" data-title="Histamina" data-language-autonym="Català" data-language-local-name="katalonski" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%DA%BE%DB%8C%D8%B3%D8%AA%D8%A7%D9%85%DB%8C%D9%86" title="ھیستامین – soranski kurdski" lang="ckb" hreflang="ckb" data-title="ھیستامین" data-language-autonym="کوردی" data-language-local-name="soranski kurdski" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Histamin" title="Histamin – češki" lang="cs" hreflang="cs" data-title="Histamin" data-language-autonym="Čeština" data-language-local-name="češki" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Histamin" title="Histamin – danski" lang="da" hreflang="da" data-title="Histamin" data-language-autonym="Dansk" data-language-local-name="danski" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Histamin" title="Histamin – njemački" lang="de" hreflang="de" data-title="Histamin" data-language-autonym="Deutsch" data-language-local-name="njemački" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%99%CF%83%CF%84%CE%B1%CE%BC%CE%AF%CE%BD%CE%B7" title="Ισταμίνη – grčki" lang="el" hreflang="el" data-title="Ισταμίνη" data-language-autonym="Ελληνικά" data-language-local-name="grčki" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Histamine" title="Histamine – engleski" lang="en" hreflang="en" data-title="Histamine" data-language-autonym="English" data-language-local-name="engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Histamino" title="Histamino – esperanto" lang="eo" hreflang="eo" data-title="Histamino" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Histamina" title="Histamina – španjolski" lang="es" hreflang="es" data-title="Histamina" data-language-autonym="Español" data-language-local-name="španjolski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Histamiin" title="Histamiin – estonski" lang="et" hreflang="et" data-title="Histamiin" data-language-autonym="Eesti" data-language-local-name="estonski" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Histamina" title="Histamina – baskijski" lang="eu" hreflang="eu" data-title="Histamina" data-language-autonym="Euskara" data-language-local-name="baskijski" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%87%DB%8C%D8%B3%D8%AA%D8%A7%D9%85%DB%8C%D9%86" title="هیستامین – perzijski" lang="fa" hreflang="fa" data-title="هیستامین" data-language-autonym="فارسی" data-language-local-name="perzijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Histamiini" title="Histamiini – finski" lang="fi" hreflang="fi" data-title="Histamiini" data-language-autonym="Suomi" data-language-local-name="finski" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Histamine" title="Histamine – francuski" lang="fr" hreflang="fr" data-title="Histamine" data-language-autonym="Français" data-language-local-name="francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Hiostaim%C3%ADn" title="Hiostaimín – irski" lang="ga" hreflang="ga" data-title="Hiostaimín" data-language-autonym="Gaeilge" data-language-local-name="irski" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Histamina" title="Histamina – galicijski" lang="gl" hreflang="gl" data-title="Histamina" data-language-autonym="Galego" data-language-local-name="galicijski" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%94%D7%99%D7%A1%D7%98%D7%9E%D7%99%D7%9F" title="היסטמין – hebrejski" lang="he" hreflang="he" data-title="היסטמין" data-language-autonym="עברית" data-language-local-name="hebrejski" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B9%E0%A4%BF%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A4%BE%E0%A4%AE%E0%A4%BF%E0%A4%A8" title="हिस्टामिन – hindski" lang="hi" hreflang="hi" data-title="हिस्टामिन" data-language-autonym="हिन्दी" data-language-local-name="hindski" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Hisztamin" title="Hisztamin – mađarski" lang="hu" hreflang="hu" data-title="Hisztamin" data-language-autonym="Magyar" data-language-local-name="mađarski" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%80%D5%AB%D5%BD%D5%BF%D5%A1%D5%B4%D5%AB%D5%B6" title="Հիստամին – armenski" lang="hy" hreflang="hy" data-title="Հիստամին" data-language-autonym="Հայերեն" data-language-local-name="armenski" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Histamin" title="Histamin – indonezijski" lang="id" hreflang="id" data-title="Histamin" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonezijski" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Istamina" title="Istamina – talijanski" lang="it" hreflang="it" data-title="Istamina" data-language-autonym="Italiano" data-language-local-name="talijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%92%E3%82%B9%E3%82%BF%E3%83%9F%E3%83%B3" title="ヒスタミン – japanski" lang="ja" hreflang="ja" data-title="ヒスタミン" data-language-autonym="日本語" data-language-local-name="japanski" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Гистамин – kazaški" lang="kk" hreflang="kk" data-title="Гистамин" data-language-autonym="Қазақша" data-language-local-name="kazaški" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%9E%88%EC%8A%A4%ED%83%80%EB%AF%BC" title="히스타민 – korejski" lang="ko" hreflang="ko" data-title="히스타민" data-language-autonym="한국어" data-language-local-name="korejski" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Гистамин – kirgiski" lang="ky" hreflang="ky" data-title="Гистамин" data-language-autonym="Кыргызча" data-language-local-name="kirgiski" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Histaminum" title="Histaminum – latinski" lang="la" hreflang="la" data-title="Histaminum" data-language-autonym="Latina" data-language-local-name="latinski" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Histaminas" title="Histaminas – litavski" lang="lt" hreflang="lt" data-title="Histaminas" data-language-autonym="Lietuvių" data-language-local-name="litavski" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Хистамин – makedonski" lang="mk" hreflang="mk" data-title="Хистамин" data-language-autonym="Македонски" data-language-local-name="makedonski" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%B9%E0%B4%BF%E0%B4%B8%E0%B5%8D%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B4%AE%E0%B4%BF%E0%B5%BB" title="ഹിസ്റ്റമിൻ – malajalamski" lang="ml" hreflang="ml" data-title="ഹിസ്റ്റമിൻ" data-language-autonym="മലയാളം" data-language-local-name="malajalamski" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Histamin" title="Histamin – malajski" lang="ms" hreflang="ms" data-title="Histamin" data-language-autonym="Bahasa Melayu" data-language-local-name="malajski" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Histamine" title="Histamine – nizozemski" lang="nl" hreflang="nl" data-title="Histamine" data-language-autonym="Nederlands" data-language-local-name="nizozemski" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Histamin" title="Histamin – norveški bokmål" lang="nb" hreflang="nb" data-title="Histamin" data-language-autonym="Norsk bokmål" data-language-local-name="norveški bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Istamina" title="Istamina – okcitanski" lang="oc" hreflang="oc" data-title="Istamina" data-language-autonym="Occitan" data-language-local-name="okcitanski" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Histamina" title="Histamina – poljski" lang="pl" hreflang="pl" data-title="Histamina" data-language-autonym="Polski" data-language-local-name="poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Histamina" title="Histamina – portugalski" lang="pt" hreflang="pt" data-title="Histamina" data-language-autonym="Português" data-language-local-name="portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Histamin%C4%83" title="Histamină – rumunjski" lang="ro" hreflang="ro" data-title="Histamină" data-language-autonym="Română" data-language-local-name="rumunjski" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Гистамин – ruski" lang="ru" hreflang="ru" data-title="Гистамин" data-language-autonym="Русский" data-language-local-name="ruski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sco mw-list-item"><a href="https://sco.wikipedia.org/wiki/Histamine" title="Histamine – škotski" lang="sco" hreflang="sco" data-title="Histamine" data-language-autonym="Scots" data-language-local-name="škotski" class="interlanguage-link-target"><span>Scots</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Histamin" title="Histamin – srpsko-hrvatski" lang="sh" hreflang="sh" data-title="Histamin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="srpsko-hrvatski" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-si mw-list-item"><a href="https://si.wikipedia.org/wiki/%E0%B7%84%E0%B7%92%E0%B7%83%E0%B7%8A%E0%B6%A7%E0%B6%B8%E0%B7%92%E0%B6%B1%E0%B7%8A" title="හිස්ටමින් – sinhaleški" lang="si" hreflang="si" data-title="හිස්ටමින්" data-language-autonym="සිංහල" data-language-local-name="sinhaleški" class="interlanguage-link-target"><span>සිංහල</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Histamine" title="Histamine – Simple English" lang="en-simple" hreflang="en-simple" data-title="Histamine" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Histam%C3%ADn" title="Histamín – slovački" lang="sk" hreflang="sk" data-title="Histamín" data-language-autonym="Slovenčina" data-language-local-name="slovački" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Histamin" title="Histamin – slovenski" lang="sl" hreflang="sl" data-title="Histamin" data-language-autonym="Slovenščina" data-language-local-name="slovenski" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Histamin" title="Histamin – srpski" lang="sr" hreflang="sr" data-title="Histamin" data-language-autonym="Српски / srpski" data-language-local-name="srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Histamin" title="Histamin – švedski" lang="sv" hreflang="sv" data-title="Histamin" data-language-autonym="Svenska" data-language-local-name="švedski" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%A4%E0%AE%BF%E0%AE%9A%E0%AF%81%E0%AE%A8%E0%AF%80%E0%AE%B0%E0%AF%8D%E0%AE%A4%E0%AF%8D%E0%AE%A4%E0%AF%87%E0%AE%95%E0%AF%8D%E0%AE%95%E0%AE%BF" title="திசுநீர்த்தேக்கி – tamilski" lang="ta" hreflang="ta" data-title="திசுநீர்த்தேக்கி" data-language-autonym="தமிழ்" data-language-local-name="tamilski" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%B9%E0%B0%BF%E0%B0%B8%E0%B1%8D%E0%B0%9F%E0%B0%AE%E0%B0%BF%E0%B0%A8%E0%B1%8D" title="హిస్టమిన్ – teluški" lang="te" hreflang="te" data-title="హిస్టమిన్" data-language-autonym="తెలుగు" data-language-local-name="teluški" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%AE%E0%B8%B4%E0%B8%AA%E0%B8%95%E0%B8%B2%E0%B8%A1%E0%B8%B5%E0%B8%99" title="ฮิสตามีน – tajlandski" lang="th" hreflang="th" data-title="ฮิสตามีน" data-language-autonym="ไทย" data-language-local-name="tajlandski" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/Histamina" title="Histamina – tagalog" lang="tl" hreflang="tl" data-title="Histamina" data-language-autonym="Tagalog" data-language-local-name="tagalog" class="interlanguage-link-target"><span>Tagalog</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Histamin" title="Histamin – turski" lang="tr" hreflang="tr" data-title="Histamin" data-language-autonym="Türkçe" data-language-local-name="turski" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D1%96%D1%81%D1%82%D0%B0%D0%BC%D1%96%D0%BD" title="Гістамін – ukrajinski" lang="uk" hreflang="uk" data-title="Гістамін" data-language-autonym="Українська" data-language-local-name="ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Gistamin" title="Gistamin – uzbečki" lang="uz" hreflang="uz" data-title="Gistamin" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="uzbečki" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Histamin" title="Histamin – vijetnamski" lang="vi" hreflang="vi" data-title="Histamin" data-language-autonym="Tiếng Việt" data-language-local-name="vijetnamski" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-war mw-list-item"><a href="https://war.wikipedia.org/wiki/Histamin" title="Histamin – waray" lang="war" hreflang="war" data-title="Histamin" data-language-autonym="Winaray" data-language-local-name="waray" class="interlanguage-link-target"><span>Winaray</span></a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E7%BB%84%E8%83%BA" title="组胺 – wu kineski" lang="wuu" hreflang="wuu" data-title="组胺" data-language-autonym="吴语" data-language-local-name="wu kineski" class="interlanguage-link-target"><span>吴语</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%B5%84%E7%B9%94%E8%83%BA" title="組織胺 – kineski" lang="zh" hreflang="zh" data-title="組織胺" data-language-autonym="中文" data-language-local-name="kineski" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E7%B5%84%E7%B9%94%E8%83%BA" title="組織胺 – kantonski" lang="yue" hreflang="yue" data-title="組織胺" data-language-autonym="粵語" data-language-local-name="kantonski" class="interlanguage-link-target"><span>粵語</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q61233#sitelinks-wikipedia" title="Poveznice na druge jezike" class="wbc-editpage">Uredi poveznice</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div 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class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Razno </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Posebno:%C5%A0to_vodi_ovamo/Histamin" title="Popis svih stranica koje sadrže poveznice na ovu stranicu [j]" accesskey="j"><span>Što vodi ovamo</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:Povezane_promjene/Histamin" rel="nofollow" title="Nedavne promjene na stranicama koje su povezane s navedenom stranicom [k]" accesskey="k"><span>Povezane promjene</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedija:Upload" title="Postavi datoteke [u]" accesskey="u"><span>Postavi datoteku</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:Posebne_stranice" title="Popis svih posebnih stranica [q]" accesskey="q"><span>Posebne stranice</span></a></li><li id="t-permalink" 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id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="hr" dir="ltr"><p><b>Histamin</b> je biogeni <a href="/wiki/Amin" class="mw-disambig" title="Amin">amin</a> koji je uključen u lokalni <a href="/wiki/Imunolo%C5%A1ki_sustav" class="mw-redirect" title="Imunološki sustav">imunosni</a> odgovor, kao i reguliranje <a href="/wiki/Fiziologija" title="Fiziologija">fizioloških</a> funkcija crijeva te djeluje kao neuroprijenosnik.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Histamin aktivira upalni odgovor. Kao dio imunološkog odgovora na strane patogene, histamin proizvode bazofili i mastociti koji se nalaze u okolnom vezivnom tkivu.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Histamin povećava propusnost kapilara za leukocite i druge proteine kako bi se mogli uključiti u borbu protiv stranih tijela. Histamin je pronađen u gotovo svim animalnim stanicama. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Svojstva">Svojstva</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=1" title="Uredi odlomak: Svojstva" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=1" title="Uredi kôd odjeljka Svojstva"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Histamine_tautomers.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ea/Histamine_tautomers.svg/350px-Histamine_tautomers.svg.png" decoding="async" width="350" height="83" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ea/Histamine_tautomers.svg/525px-Histamine_tautomers.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ea/Histamine_tautomers.svg/700px-Histamine_tautomers.svg.png 2x" data-file-width="400" data-file-height="95" /></a><figcaption>Tautomeri histamina</figcaption></figure> <p>Histamin stvara bezbojan higroskopan <a href="/wiki/Kristal" title="Kristal">kristal</a> koji se topi pri 84 °C i lako se otapa u <a href="/wiki/Voda" title="Voda">vodi</a> ili <a href="/wiki/Etanol" title="Etanol">etanolu</a>, ali ne u <a href="/wiki/Eter" class="mw-disambig" title="Eter">eteru</a>. U vodenoj otopini histamina postoji u dva oblika tautomera, Nπ-H-histamin i Nτ-H-histamin. </p><p>Histamin ima dva <a href="/wiki/Lu%C5%BEine" title="Lužine">bazična</a> (lužnata) centra, naime alifatska aminoskupina i bilo koji <a href="/wiki/Du%C5%A1ik" title="Dušik">dušikov</a> <a href="/wiki/Atom" title="Atom">atom</a> imidazolnog prstena koji već nema <a href="/wiki/Proton" title="Proton">proton</a>. Pod određenim fiziološkim uvjetima alifatskoj amino skupini će biti dodan proton, dok je drugi atom dušika iz imidazolnog prstena neće.<sup id="cite_ref-Paiva_1970_3-0" class="reference"><a href="#cite_note-Paiva_1970-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Također, za histamin je normalno da mu proton predaje kation sa samo jednim nabojem. </p> <div class="mw-heading mw-heading2"><h2 id="Sinteza_i_metabolizam">Sinteza i metabolizam</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=2" title="Uredi odlomak: Sinteza i metabolizam" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=2" title="Uredi kôd odjeljka Sinteza i metabolizam"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Histamin se derivira dekaroboksilacijom iz aminokiseline histida u reakciji koju katalizira enzim L-histidin dekarboksilaza. To je hidrofilni vazoaktivni amin. </p> <figure class="mw-halign-center" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Histidine_decarboxylase.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Histidine_decarboxylase.svg/433px-Histidine_decarboxylase.svg.png" decoding="async" width="433" height="123" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Histidine_decarboxylase.svg/650px-Histidine_decarboxylase.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Histidine_decarboxylase.svg/866px-Histidine_decarboxylase.svg.png 2x" data-file-width="512" data-file-height="145" /></a><figcaption>Pretvorba histidina u histamin preko enzima L-histidin dekarboksilaze</figcaption></figure> <p>Kada jednom nastane, histamin se ili skladišti ili se brzo deaktivira. Histamin koji se otpusti u sinapse se razlaže pod utjecajem acetaldehid dehidrogenaze. Ono što aktivira alergijsku reakciju je nedostatak ovog enzima, zbog čega se histamin nakupi u sinapsama. Histamin razlažu histamin-N-metiltransferaze i diamin oksidaza. Neke vrste bolesti prenosivih hranom su uzrokovane pretvorbom histidina u histamin u pokvarenoj hrani. </p> <div class="mw-heading mw-heading2"><h2 id="Skladištenje_i_otpuštanje"><span id="Skladi.C5.A1tenje_i_otpu.C5.A1tanje"></span>Skladištenje i otpuštanje</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=3" title="Uredi odlomak: Skladištenje i otpuštanje" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=3" title="Uredi kôd odjeljka Skladištenje i otpuštanje"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Većinu histamina u tijelu stvaraju granule u mastocitima ili u bijelim krvnim stanicama koje se nazivaju <a href="/w/index.php?title=Bazofili&action=edit&redlink=1" class="new" title="Bazofili (stranica ne postoji)">bazofili</a>. Mastociti su posebno brojni na mjestima moguće ozljede - u <a href="/wiki/Nos" title="Nos">nosu</a>, <a href="/wiki/Usta" title="Usta">ustima</a>, na stopalima i krvnim žilama. Histamin koji nije stvoren u mastocitima se nalazi u nekoliko tkiva, primjerice mozgu, gdje djeluje kao neuroprijenosnik. Još jedno važno mjesto spremanja i otpuštanja histamina je enterokromafina stanica u <a href="/wiki/%C5%BDeludac" title="Želudac">želucu</a>. </p><p>Najvažniji patofiziološki mehanizam u kojem mastociti i bazofili otpuštaju histamin je imunološki. Ove stanice, ako su na njih djelovala IgE <a href="/w/index.php?title=Imunoglobulini&action=edit&redlink=1" class="new" title="Imunoglobulini (stranica ne postoji)">imunoglobulini</a> i spojili se s njihovim membranama, degranuliraju kada dođu u kontakt s antigenom. Određeni amini i alkaloidi, uključujući droge poput morfina mogu uzrokovati otpuštanje histamina. Određeni <a href="/wiki/Antibiotici" class="mw-redirect" title="Antibiotici">antibiotici</a> mogu imati isto djelovanje. </p> <div class="mw-heading mw-heading2"><h2 id="Mehanizam_djelovanja">Mehanizam djelovanja</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=4" title="Uredi odlomak: Mehanizam djelovanja" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=4" title="Uredi kôd odjeljka Mehanizam djelovanja"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Histamin djeluje spajajući se na određene stanične histaminske <a href="/wiki/Receptor" title="Receptor">receptore</a>. Četiri histaminska receptora su otkrivena i dodijeljena su im imena od H1 do H4. </p> <table class="wikitable"> <tbody><tr> <td><b>Vrsta</b></td> <td><b>Lokacija</b></td> <td><b>Funkcija</b> </td></tr> <tr> <td>Histaminski H1 receptor</td> <td>Pronađen je u glatkim mišićima, endotelijumu, i tkivu središnjeg živčanog sustava</td> <td>Uzrokuje vazodilataciju, bronhokonstrinkciju, kontrakcije glatkih mišića bronhija, razdvajanje endotelnih stanica (uzrokuje <a href="/w/index.php?title=Urikarija&action=edit&redlink=1" class="new" title="Urikarija (stranica ne postoji)">urikariju</a>), bol i svrbež zbog uboda insekata; primarni receptori su uključeni su simptome peludne groznice i alergijskog rinitisa te bolesti putovanja. </td></tr> <tr> <td>Histaminski H2 receptor</td> <td>Pronađen parijetalnim stanicama</td> <td>Primarno služi za stimulaciju lučenja želučane kiseline </td></tr> <tr> <td>Histaminski H3 receptor</td> <td>Pronađen u tkivu središnjeg i perifernog živčanog sustava (u manjoj mjeri)</td> <td>Smanjuje otpuštanje neuroprijenosnika: <a class="mw-selflink selflink">histamina</a>, <a href="/wiki/Acetilkolin" title="Acetilkolin">acetilkolina</a>, <a href="/wiki/Adrenalin" title="Adrenalin">adrenalina</a> i <a href="/wiki/Serotonin" title="Serotonin">serotonina</a>. </td></tr> <tr> <td>Histaminski H4 receptor</td> <td>Pronađen pretežito u bazofilima i koštanoj srži. Također je pronađen na timusu, u slezeni, i crijevu.</td> <td>Imaju ulogu u <a href="/w/index.php?title=Kemotaksija&action=edit&redlink=1" class="new" title="Kemotaksija (stranica ne postoji)">kemotaksiji</a>. </td></tr></tbody></table> <p>Histamin djeluje kao neuroprijenosnik. Neuroni koji oslobađaju histamin nalaze se u zadnjem dijelu <a href="/wiki/Hipotalamus" title="Hipotalamus">hipotalamusa</a>. Histamin djeluje na spavanje, pa antihistamini (antagonisti H1 histaminskih receptora) potiču spavanje. Isto tako, uništavanje neurona koji proizvode histamin, ili inhibiranje histaminske <a href="/wiki/Sinteza" title="Sinteza">sinteze</a> dovodi do poteškoća s koncentriranjem. Također, antagonisti H3 receptora pojačavaju budnost. </p><p>Pokazalo se da su stanice koje proizvode histamin najjaktivnije u procesu buđenja od svih ostali neuroloških. Najjaktivnije su za vrijeme buđenja, uspore se za vrijeme odmora ili umora, i potpuno prestanu otpuštati histamin za vrijeme REM i non-REM faze <a href="/wiki/San" class="mw-redirect" title="San">sna</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Supresivni_efekti">Supresivni efekti</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=5" title="Uredi odlomak: Supresivni efekti" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=5" title="Uredi kôd odjeljka Supresivni efekti"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Iako histamin ima stimulatorni efekt na neuronima, isto tako destimulira one koji štite od konvulzija, preosjetljivosti živaca, <a href="/wiki/Stres" class="mw-redirect" title="Stres">stresa</a> i droge.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Isto tako, istraživanja pokazuju da je histamin kontrolira mehanizme preko kojih se sjećanja, znanje i vještine zaboravljaju.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Erekcija_i_uloga_u_seksu">Erekcija i uloga u seksu</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=6" title="Uredi odlomak: Erekcija i uloga u seksu" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=6" title="Uredi kôd odjeljka Erekcija i uloga u seksu"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Gubitak libida i erektilna disfunkcija mogu uslijediti nakon uzimanja antagonista H2 receptora.<sup id="cite_ref-White_6-0" class="reference"><a href="#cite_note-White-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Injekcija histamina u kavernozno tijelo u muškaraca sa psihogeničnom impotencijom dovodi do pune ili djelomične erekcije u 74% njih.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Istraživanja su pokazala da antagonisti H2 receptora mogu uzrokovati seksualne poteškoće zbog smanjivanja količine testosterona. </p> <div class="mw-heading mw-heading3"><h3 id="Shizofrenija">Shizofrenija</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=7" title="Uredi odlomak: Shizofrenija" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=7" title="Uredi kôd odjeljka Shizofrenija"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Metaboliti histamina su kod <a href="/wiki/Shizofrenija" title="Shizofrenija">shizofreničara</a> povećani dok je broj H1 receptora smanjen. Mnogi antipsihotici djeluju na histamin povećavajući ga.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Poremećaji"><span id="Poreme.C4.87aji"></span>Poremećaji</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=8" title="Uredi odlomak: Poremećaji" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=8" title="Uredi kôd odjeljka Poremećaji"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kao osnovni dio imunološkog sustava, histamin je uključen u alergije i razne imunološke poremećaje. </p> <div class="mw-heading mw-heading2"><h2 id="Izvori">Izvori</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histamin&veaction=edit&section=9" title="Uredi odlomak: Izvori" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histamin&action=edit&section=9" title="Uredi kôd odjeljka Izvori"><span>uredi kôd</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r6541845">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r7012897">.mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"»""«"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}</style><cite id="CITEREFMarieb,_E.2001" class="citation book cs1">Marieb, E. 2001. <i>Human anatomy & physiology</i>. Benjamin Cummings. San Francisco. str. 414. <a href="/wiki/ISBN" class="mw-redirect" title="ISBN">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/0-8053-4989-8" title="Posebno:Traži ISBN/0-8053-4989-8"><bdi>0-8053-4989-8</bdi></a></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Human+anatomy+%26+physiology&rft.place=San+Francisco&rft.pages=414&rft.pub=Benjamin+Cummings&rft.date=2001&rft.isbn=0-8053-4989-8&rft.au=Marieb%2C+E.&rfr_id=info%3Asid%2Fhr.wikipedia.org%3AHistamin" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r7012897"><cite id="CITEREFDi_Giuseppe2003" class="citation book cs1">Di Giuseppe, Maurice. 2003. <i>Nelson Biology 12</i>. Thomson Canada Ltd.. Toronto. str. 473. <a href="/wiki/ISBN" class="mw-redirect" title="ISBN">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/0-17-625987-2" title="Posebno:Traži ISBN/0-17-625987-2"><bdi>0-17-625987-2</bdi></a></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Nelson+Biology+12&rft.place=Toronto&rft.pages=473&rft.pub=Thomson+Canada+Ltd.&rft.date=2003&rft.isbn=0-17-625987-2&rft.aulast=Di+Giuseppe&rft.aufirst=Maurice&rfr_id=info%3Asid%2Fhr.wikipedia.org%3AHistamin" class="Z3988"></span></span> </li> <li id="cite_note-Paiva_1970-3"><span class="mw-cite-backlink"><a href="#cite_ref-Paiva_1970_3-0">↑</a></span> <span class="reference-text">Paiva T.B., Tominaga M. & Paiva A.C. (1970). Ionization of histamine, N-acetylhistamine, and their iodinated derivatives. <i>J. Med. Chem.</i>, <b>13</b>, 689–692.</span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Yanai K, Tashiro M. (2007). The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies. Pharmacol Ther. 113(1):1-15. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/16890992?dopt=Abstract">PMID 16890992</a></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Alvarez EO. (2009). The role of histamine on cognition. Behav Brain Res. 199(2):183-9. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/19126417?dopt=Abstract">PMID 19126417</a></span> </li> <li id="cite_note-White-6"><span class="mw-cite-backlink"><a href="#cite_ref-White_6-0">↑</a></span> <span class="reference-text">White JM, Rumbold GR. (1988).Behavioural effects of histamine and its antagonists: a review. Psychopharmacology, 95(1):1-14. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/3133686?dopt=Abstract">PMID 3133686</a></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">Cará AM, Lopes-Martins RA, Antunes E, Nahoum CR, De Nucci G. (1995). The role of histamine in human penile erection. Br J Urol. 75(2):220-4. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/7850330?dopt=Abstract">PMID 7850330</a></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text">Ito C. (2004). The role of the central histaminergic system on schizophrenia. Drug News Perspect. 17(6):383-7. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/15334189?dopt=Abstract">PMID 15334189</a></span> </li> </ol></div></div> <table class="navbox" cellspacing="0" style=";"><tbody><tr><td style="padding:2px;"><table cellspacing="0" class="nowraplinks collapsible autocollapse" style="width:100%;background:transparent;color:inherit;;"><tbody><tr><th style=";" colspan="2" class="navbox-naslov"><div style="float:left; width:6em;text-align:left;"><div class="noprint plainlinksneverexpand navbar" style="background-color:transparent; padding:0; white-space:nowrap; font-weight:normal; font-variant:small-caps; ;;border:none;;"><a href="/wiki/Predlo%C5%BEak:Neurotransmiteri" title="Predložak:Neurotransmiteri"><span title="Vidi ovaj predložak." style=";;border:none;;">v</span></a> • <a class="external text" href="https://hr.wikipedia.org/w/index.php?title=Predlo%C5%BEak:Neurotransmiteri&action=edit"><span style="color:#002bb8;;;border:none;;" title="Možete urediti ovaj predložak. Prije spremanja provjerite kako će izgledati.">u</span></a></div></div><span style="font-size:110%;"><a href="/wiki/Neurotransmiter" class="mw-redirect" title="Neurotransmiter">neurotransmiteri</a></span></th></tr><tr style="height:2px;"><td></td></tr><tr><td class="navbox-grupa" style=";;"><a href="/wiki/Aminokiselina" title="Aminokiselina">aminokiseline</a></td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-neparni"><div style="padding:0em 0.25em"><a href="/wiki/Alanin" title="Alanin">alanin</a> <b>·</b> <a href="/wiki/Asparaginska_kiselina" title="Asparaginska kiselina">aspartat</a> <b>·</b> <a href="/w/index.php?title=Cikloserin&action=edit&redlink=1" class="new" title="Cikloserin (stranica ne postoji)">cikloserin</a> <b>·</b> <a href="/w/index.php?title=Dimetilglicin&action=edit&redlink=1" class="new" title="Dimetilglicin (stranica ne postoji)">DMG</a> <b>·</b> <a href="/wiki/Gama-aminomasla%C4%8Dna_kiselina" title="Gama-aminomaslačna kiselina">GABA</a> <b>·</b> <a href="/wiki/Glicin" title="Glicin">glicin</a> <b>·</b> <a href="/wiki/Glutaminska_kiselina" title="Glutaminska kiselina">glutamat</a> <b>·</b> <a href="/w/index.php?title=Hipotaurin&action=edit&redlink=1" class="new" title="Hipotaurin (stranica ne postoji)">hipotaurin</a> <b>·</b> <a href="/w/index.php?title=Kinurenska_kiselina&action=edit&redlink=1" class="new" title="Kinurenska kiselina (stranica ne postoji)">kinurenska kiselina (transtorin)</a> <b>·</b> <a href="/w/index.php?title=N-acetilaspartilglutaminska_kiselina&action=edit&redlink=1" class="new" title="N-acetilaspartilglutaminska kiselina (stranica ne postoji)">NAAG (spaglumična kiselina)</a> <b>·</b> <a href="/w/index.php?title=Sarkozin&action=edit&redlink=1" class="new" title="Sarkozin (stranica ne postoji)">NMG (sarkozin)</a> <b>·</b> <a href="/wiki/Serin" title="Serin">serin</a> <b>·</b> <a href="/wiki/Taurin" title="Taurin">taurin</a> <b>·</b> <a href="/w/index.php?title=Trimetilglicin&action=edit&redlink=1" class="new" title="Trimetilglicin (stranica ne postoji)">TMG (betain)</a></div></td></tr><tr style="height:2px"><td></td></tr><tr><td class="navbox-grupa" style=";;"><a href="/w/index.php?title=Endokanabinoidi&action=edit&redlink=1" class="new" title="Endokanabinoidi (stranica ne postoji)">endokanabinoidi</a></td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-parni"><div style="padding:0em 0.25em"><a href="/w/index.php?title=2-arahidonoilglicerol&action=edit&redlink=1" class="new" title="2-arahidonoilglicerol (stranica ne postoji)">2-AG</a> <b>·</b> <a href="/w/index.php?title=2-arahidonil-gliceril-eter&action=edit&redlink=1" class="new" title="2-arahidonil-gliceril-eter (stranica ne postoji)">2-AGE (noladin-eter)</a> <b>·</b> <a href="/w/index.php?title=Anandamid&action=edit&redlink=1" class="new" title="Anandamid (stranica ne postoji)">AEA (anandamid)</a> <b>·</b> <a href="/w/index.php?title=N-arahidonoildopamin&action=edit&redlink=1" class="new" title="N-arahidonoildopamin (stranica ne postoji)">NADA</a> <b>·</b> <a href="/w/index.php?title=Virodamin&action=edit&redlink=1" class="new" title="Virodamin (stranica ne postoji)">OAE (virodamin)</a> <b>·</b> <a href="/w/index.php?title=Oleamid&action=edit&redlink=1" class="new" title="Oleamid (stranica ne postoji)">oleamid</a> <b>·</b> <a href="/w/index.php?title=Palmitoiletanolamid&action=edit&redlink=1" class="new" title="Palmitoiletanolamid (stranica ne postoji)">PEA (palmitoiletanolamid)</a> <b>·</b> <a href="/w/index.php?title=RVD-Hp%CE%B1&action=edit&redlink=1" class="new" title="RVD-Hpα (stranica ne postoji)">RVD-Hpα</a> <b>·</b> <a href="/w/index.php?title=Hemopresin&action=edit&redlink=1" class="new" title="Hemopresin (stranica ne postoji)">Hp (hemopresin)</a></div></td></tr><tr style="height:2px"><td></td></tr><tr><td class="navbox-grupa" style=";;"><a href="/w/index.php?title=Plinski_transmiteri&action=edit&redlink=1" class="new" title="Plinski transmiteri (stranica ne postoji)">plinski transmiteri</a></td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-neparni"><div style="padding:0em 0.25em"><a href="/wiki/Du%C5%A1ikov(I)_oksid" title="Dušikov(I) oksid">didušikov oksid</a> <b>·</b> <a href="/wiki/Du%C5%A1ikov(II)_oksid" title="Dušikov(II) oksid">dušikov monoksid</a> <b>·</b> <a href="/wiki/Ugljikov_monoksid" class="mw-redirect" title="Ugljikov monoksid">ugljikov monoksid</a> <b>·</b> <a href="/wiki/Sumporovodik" title="Sumporovodik">sumporovodik</a></div></td></tr><tr style="height:2px"><td></td></tr><tr><td class="navbox-grupa" style=";;"><a href="/w/index.php?title=Monoaminski_neutransmiteri&action=edit&redlink=1" class="new" title="Monoaminski neutransmiteri (stranica ne postoji)">monoamini</a></td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-parni"><div style="padding:0em 0.25em"><a href="/wiki/Adrenalin" title="Adrenalin">adrenalin (epinefrin)</a> <b>·</b> <a href="/wiki/Dopamin" title="Dopamin">dopamin</a> <b>·</b> <a href="/w/index.php?title=Melatonin&action=edit&redlink=1" class="new" title="Melatonin (stranica ne postoji)">melatonin</a> <b>·</b> <a href="/w/index.php?title=N-acetilserotonin&action=edit&redlink=1" class="new" title="N-acetilserotonin (stranica ne postoji)">NAS (normelatonin)</a> <b>·</b> <a href="/wiki/Noradrenalin" title="Noradrenalin">noradrenalin (norepinefrin)</a> <b>·</b> <a href="/wiki/Serotonin" title="Serotonin">serotonin (5-HT)</a></div></td></tr><tr style="height:2px"><td></td></tr><tr><td class="navbox-grupa" style=";;"><a href="/w/index.php?title=Purini&action=edit&redlink=1" class="new" title="Purini (stranica ne postoji)">purini</a></td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-neparni"><div style="padding:0em 0.25em"><a href="/wiki/Adenozin" title="Adenozin">adenozin</a> <b>·</b> <a href="/wiki/Adenozin_difosfat" title="Adenozin difosfat">ADP</a> <b>·</b> <a href="/wiki/Adenozin_monofosfat" title="Adenozin monofosfat">AMP</a> <b>·</b> <a href="/wiki/Adenozin_trifosfat" title="Adenozin trifosfat">ATP</a></div></td></tr><tr style="height:2px"><td></td></tr><tr><td class="navbox-grupa" style=";;"><a href="/w/index.php?title=Amini_u_tragovima&action=edit&redlink=1" class="new" title="Amini u tragovima (stranica ne postoji)">amini u tragovima</a></td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-parni"><div style="padding:0em 0.25em"><a href="/w/index.php?title=3-jodotironamin&action=edit&redlink=1" class="new" title="3-jodotironamin (stranica ne postoji)">3-ITA</a> <b>·</b> <a href="/w/index.php?title=5-MeO-DMT&action=edit&redlink=1" class="new" title="5-MeO-DMT (stranica ne postoji)">5-MeO-DMT</a> <b>·</b> <a href="/w/index.php?title=Bufotenin&action=edit&redlink=1" class="new" title="Bufotenin (stranica ne postoji)">bufotenin</a> <b>·</b> <a href="/wiki/Dimetiltriptamin" title="Dimetiltriptamin">DMT</a> <b>·</b> <a href="/w/index.php?title=Fenetilamin&action=edit&redlink=1" class="new" title="Fenetilamin (stranica ne postoji)">fenetilamin</a> <b>·</b> <a href="/w/index.php?title=Norfenefrin&action=edit&redlink=1" class="new" title="Norfenefrin (stranica ne postoji)"><i>m</i>-oktopamin</a> <b>·</b> <a href="/w/index.php?title=Meta-tiramin&action=edit&redlink=1" class="new" title="Meta-tiramin (stranica ne postoji)"><i>m</i>-tiramin</a> <b>·</b> <a href="/w/index.php?title=N-metiltriptamin&action=edit&redlink=1" class="new" title="N-metiltriptamin (stranica ne postoji)">NMT</a> <b>·</b> <a href="/w/index.php?title=Oktopamin&action=edit&redlink=1" class="new" title="Oktopamin (stranica ne postoji)"><i>p</i>-oktopamin</a> <b>·</b> <a href="/w/index.php?title=Tiramin&action=edit&redlink=1" class="new" title="Tiramin (stranica ne postoji)"><i>p</i>-tiramin</a> <b>·</b> <a href="/w/index.php?title=Sinefrin&action=edit&redlink=1" class="new" title="Sinefrin (stranica ne postoji)">sinefrin</a> <b>·</b> <a href="/w/index.php?title=Tironamin&action=edit&redlink=1" class="new" title="Tironamin (stranica ne postoji)">tironamin</a> <b>·</b> <a href="/wiki/Triptamin" title="Triptamin">triptamin</a></div></td></tr><tr style="height:2px"><td></td></tr><tr><td class="navbox-grupa" style=";;">ostali</td><td style="text-align:left;border-left:2px solid #fdfdfd;width:100%;padding:0px;;;" class="navbox-popis navbox-neparni"><div style="padding:0em 0.25em"><a href="/w/index.php?title=1,4-butandiol&action=edit&redlink=1" class="new" title="1,4-butandiol (stranica ne postoji)">1,4-BD</a> <b>·</b> <a href="/wiki/Acetilkolin" title="Acetilkolin">acetilkolin</a> <b>·</b> <a href="/w/index.php?title=Gama-butirolakton&action=edit&redlink=1" class="new" title="Gama-butirolakton (stranica ne postoji)">GBL</a> <b>·</b> <a href="/w/index.php?title=Gama-hidroksimasla%C4%8Dna_kiselina&action=edit&redlink=1" class="new" title="Gama-hidroksimaslačna kiselina (stranica ne postoji)">GHB</a> <b>·</b> <a class="mw-selflink selflink">histamin</a></div></td></tr></tbody></table></td></tr></tbody></table>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Dobavljeno iz "<a dir="ltr" href="https://hr.wikipedia.org/w/index.php?title=Histamin&oldid=6247884">https://hr.wikipedia.org/w/index.php?title=Histamin&oldid=6247884</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Posebno:Kategorije" title="Posebno:Kategorije">Kategorije</a>: <ul><li><a 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