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alopecia</title> <meta name="description" content="Search results for: androgenic alopecia"> <meta name="keywords" content="androgenic alopecia"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="androgenic alopecia"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 42</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: androgenic alopecia</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">42</span> Hair Regrowth Effect of Herbal Formula on Androgenic Alopecia Rat Model </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jian-You%20Wang">Jian-You Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Feng%20Yi%20Hsu"> Feng Yi Hsu</a>, <a href="https://publications.waset.org/abstracts/search?q=Chieh-Hsi%20Wu"> Chieh-Hsi Wu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Androgenetic alopecia (AGA) is an androgen-dependent disorder caused by excess testosterone in blood capillaries or excess enzyme activity of 5α- reductase in hair follicles. Plants, alone or in combination, have been widely used for hair growth promotion since ancient times in Asia. In this study, the efficacy of a traditional Chinese herbal formula, Shen-Ying-Yang-Zhen-Dan (SYYZD) with different kinds of extract solvents, facilitating hair regrowth in testosterone-induced hair loss have been determined. The study was performed by treating with either 95 % ethanol aqueous extracts, 50% ethanol aqueous extracts or deionized water extracts orally in four-week-old male S.D. rats that experienced hair regrowth interruption induced by testosterone treatment. The 50% ethanol aqueous extracts group showed better hair regrowth promotion activities than either 95% ethanol aqueous extracts or deionized water extracts groups in 14 days treatment. In conclusion, our results suggest that 50% ethanol aqueous SYYZD extracts have hair growth promoting potential and may be beneficial as an alternative medicine for androgenetic alopecia treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shen-Ying-Yang-Zhen-Dan" title="Shen-Ying-Yang-Zhen-Dan">Shen-Ying-Yang-Zhen-Dan</a>, <a href="https://publications.waset.org/abstracts/search?q=androgenic%20alopecia" title=" androgenic alopecia"> androgenic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=hair%20loss" title=" hair loss"> hair loss</a>, <a href="https://publications.waset.org/abstracts/search?q=hair%20growth%20promotion" title=" hair growth promotion"> hair growth promotion</a>, <a href="https://publications.waset.org/abstracts/search?q=hair%20regrowth%20effect" title=" hair regrowth effect"> hair regrowth effect</a> </p> <a href="https://publications.waset.org/abstracts/16355/hair-regrowth-effect-of-herbal-formula-on-androgenic-alopecia-rat-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16355.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">777</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">41</span> Evaluating the Effectiveness of Mesotherapy and Topical 2% Minoxidil for Androgenic Alopecia in Females, Using Topical 2% Minoxidil as a Common Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamed%20Delrobai%20Ghoochan%20Atigh">Hamed Delrobai Ghoochan Atigh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Androgenic alopecia (AGA) is a common form of hair loss, impacting approximately 50% of females, which leads to reduced self-esteem and quality of life. It causes progressive follicular miniaturization in genetically predisposed individuals. Mesotherapy -- a minimally invasive procedure, topical 2% minoxidil, and oral finasteride have emerged as popular treatment options in the realm of cosmetics. However, the efficacy of mesotherapy compared to other options remains unclear. This study aims to assess the effectiveness of mesotherapy when it is added to topical 2% minoxidil treatment on female androgenic alopecia. Mesotherapy, also known as intradermotherapy, is a technique that entails administering multiple intradermal injections of a carefully composed mixture of compounds in low doses, applied at various points in close proximity to or directly over the affected areas. This study involves a randomized controlled trial with 100 female participants diagnosed with androgenic alopecia. The subjects were randomly assigned to two groups: Group A used topical 2% minoxidil twice daily and took Finastride oral tablet. For Group B, 10 mesotherapy sessions were added to the prior treatment. The injections were administered every week in the first month of treatment, every two weeks in the second month, and after that the injections were applied monthly for four consecutive months. The response assessment was made at baseline, the 4th session, and finally after 6 months when the treatment was complete. Clinical photographs, 7-point Likert scale patient self-evaluation, and 7-point Likert scale assessment tool were used to measure the effectiveness of the treatment. During this evaluation, a significant and visible improvement in hair density and thickness was observed. The study demonstrated a significant increase in treatment efficacy in Group B compared to Group A post-treatment, with no adverse effects. Based on the findings, it appears that mesotherapy offers a significant improvement in female AGA over minoxidil. Hair loss was stopped in Group B after one month and improvement in density and thickness of hair was observed after the third month. The findings from this study provide valuable insights into the efficacy of mesotherapy in treating female androgenic alopecia. Our evaluation offers a detailed assessment of hair growth parameters, enabling a better understanding of the treatments' effectiveness. The potential of this promising technique is significantly enhanced when carried out in a medical facility, guided by appropriate indications and skillful execution. An interesting observation in our study is that in areas where the hair had turned grey, the newly regrown hair does not retain its original grey color; instead, it becomes darker. The results contribute to evidence-based decision-making in dermatological practice and offer different insights into the treatment of female pattern hair loss. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgenic%20alopecia" title="androgenic alopecia">androgenic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=female%20hair%20loss" title=" female hair loss"> female hair loss</a>, <a href="https://publications.waset.org/abstracts/search?q=mesotherapy" title=" mesotherapy"> mesotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=topical%202%25%20minoxidil" title=" topical 2% minoxidil"> topical 2% minoxidil</a> </p> <a href="https://publications.waset.org/abstracts/170838/evaluating-the-effectiveness-of-mesotherapy-and-topical-2-minoxidil-for-androgenic-alopecia-in-females-using-topical-2-minoxidil-as-a-common-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170838.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">102</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">40</span> Endocrine Therapy-Induced Alopecia in Patients with Breast Cancer in Tunisia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aref%20Zribi">Aref Zribi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sonia%20Ben%20Nasr"> Sonia Ben Nasr</a>, <a href="https://publications.waset.org/abstracts/search?q=Sana%20Fendri"> Sana Fendri</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahdi%20Balti"> Mahdi Balti</a>, <a href="https://publications.waset.org/abstracts/search?q=Abderazzek%20Haddaoui"> Abderazzek Haddaoui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Despite their benefit, Endocrine therapies (ET) are known to have substantial adverse events (AEs) such as hot flashes, mood disorders and osteoarticular pain. ET induced alopecia(EIA) is less frequently noted by patients and is less reported in the literature. The aim of our study was to report ET alopecia characteristics and their influence on patient and treatment observance. Method: We conducted a retrospective study including luminal BC patients treated in the oncology department of the military hospital of Tunis between January 2015 and December 2020. Patients treated with previous chemotherapy-inducing alopecia were excluded. Results: 145 female patients were included. The median age was 59 years. EIA was reported in 44% of cases. Alopecia was attributed to aromatase inhibitors in 53% and tamoxifen in 21%. Severity was grade 1 in 80% and grade 2 in the remaining cases. ET discontinuation because of alopecia was noted in 6.5 % of patients. Moderate improvement of alopecia was observed with topical minoxidil and Thallium metallicum 9CH homeopathy during ET in 60% of patients. Conclusions: EIA is frequent in BC patients and should be considered to improve treatment observance and patients’ quality of life. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endocrine%20therapy" title="endocrine therapy">endocrine therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=alopecia" title=" alopecia"> alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=Tunisia" title=" Tunisia"> Tunisia</a> </p> <a href="https://publications.waset.org/abstracts/137492/endocrine-therapy-induced-alopecia-in-patients-with-breast-cancer-in-tunisia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/137492.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">126</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">39</span> The Effectiveness of Scalp Cooling Therapy on Reducing Chemotherapy Induced Alopecia: A Critical Literature Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Krishna">M. Krishna</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study was intended to identify if scalp cooling therapy is effective on preventing chemotherapy-induced hair loss among cancer patients. Critical literature of non-randomized controlled trials was used to investigate whether scalp cooling therapy is effective on preventing chemotherapy-induced alopecia. The review identified that scalp cooling therapy is effective on preventing chemotherapy-induced alopecia. Most of the patients receiving chemotherapy experience alopecia. It is also perceived as the worst effect of chemotherapy. This may be severe and lead the patients to withdraw the chemo treatment. The image disturbance caused by alopecia will make the patient depressed and will lead to declined immunity. With the knowledge on effectiveness of scalp cooling therapy on preventing chemotherapy-induced alopecia, patient undergoing chemotherapy will not be hesitant to undergo the treatment. Patients are recommended to go through scalp cooling therapy every chemo cycle and the proper therapy duration is 30 minutes before, during chemo. The suggested duration of the scalp cooling therapy is 45-90 minutes for an effective and positive outcome. This finding is excluding other factors of alopecia such as menopause, therapeutic drugs, poor hair density, liver function problems, and drug regimes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alopecia" title="alopecia">alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=chemotherapy" title=" chemotherapy"> chemotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=scalp%20cooling%20therapy" title=" scalp cooling therapy"> scalp cooling therapy</a> </p> <a href="https://publications.waset.org/abstracts/111661/the-effectiveness-of-scalp-cooling-therapy-on-reducing-chemotherapy-induced-alopecia-a-critical-literature-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/111661.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">208</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">38</span> The Effectiveness of Non-surgical Treatment for Androgenetic Alopecia in Men: A Systematic Review and Meta-Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Monica%20Trifitriana">Monica Trifitriana</a>, <a href="https://publications.waset.org/abstracts/search?q=Rido%20Mulawarman"> Rido Mulawarman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Androgenetic alopecia (AGA) is a genetically predetermined disorder due to an excessive response to dihydrotestosterone (DHT). Currently, non-surgical treatment of androgenetic alopecia is more in demand by the patient. There are many non-surgical treatments, ranging from topical treatments oral medications, and procedure treatments. Objective: We aim to assess the latest evidence of the efficacy of non-surgical treatments of androgenetic alopecia in men in comparison to placebo for improving hair density, thickness, and growth. Method: We performed a comprehensive search on topics that assess non-surgical treatments of androgenetic alopecia in men from inception up until November 2021. Result: There were 24 studies out of a total of 2438 patients divided into five non-surgical treatment groups to assess the effectiveness of hair growth, namely: minoxidil 2% (MD: 8.11 hairs/cm²), minoxidil 5% (MD: 12.02 hairs/cm²), low-level laser light therapy/LLLT (MD: 12.35 hairs/cm²), finasteride 1mg (MD: 20.43 hairs/cm²), and Platelete-Rich Plasma/PRP with microneedling (MD: 26.33 hairs/cm²). All treatments had significant results for increasing hair growth, particularly in cases of androgenetic alopecia in men (P<0.00001). Conclusion: From the results, it was found that the five non-surgical treatment groups proved to be effective and significant for hair growth, particularly in cases of androgenetic alopecia in men. In order of the best non-surgical treatment for hair growth is starting from PRP with microneedling, Finasteride 1mg, LLLT, minoxidil 5%, to minoxidil 2%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgenetic%20alopecia" title="androgenetic alopecia">androgenetic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=non-surgical" title=" non-surgical"> non-surgical</a>, <a href="https://publications.waset.org/abstracts/search?q=men" title=" men"> men</a>, <a href="https://publications.waset.org/abstracts/search?q=meta-analysis" title=" meta-analysis"> meta-analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=systematic%20review" title=" systematic review"> systematic review</a> </p> <a href="https://publications.waset.org/abstracts/146939/the-effectiveness-of-non-surgical-treatment-for-androgenetic-alopecia-in-men-a-systematic-review-and-meta-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146939.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">37</span> Cytotoxicity and Androgenic Potential of Antifungal Drug Substances on MDA-KB2 Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Benchouala%20Amira">Benchouala Amira</a>, <a href="https://publications.waset.org/abstracts/search?q=Bojic%20Clement"> Bojic Clement</a>, <a href="https://publications.waset.org/abstracts/search?q=Poupin%20Pascal"> Poupin Pascal</a>, <a href="https://publications.waset.org/abstracts/search?q=Cossu%20Leguille-carole"> Cossu Leguille-carole</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of this study is to evaluate in vitro the cytotoxic and androgenic potential of several antifungal molecules (amphotericin B, econazole, ketoconazole and miconazole) on MDA-Kb2 cell lines. This biological model is an effective tool for the detection of endocrine disruptors because it responds well to the main agonist of the androgen receptor (testosterone) and also to an antagonist: flutamide. The cytotoxicity of each chemical compound tested was measured using an MTT assay (tetrazolium salt, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) which measures the activity of the reductase function of mitochondrial succinate dehydrogenase enzymes of cultured cells. This complementary cytotoxicity test is essential to ensure that the effects of reduction in luminescence intensity observed during androgenic tests are only attributable to the anti-androgenic action of the compounds tested and not to their possible cytotoxic properties. Tests of the androgenic activity of antifungals show that these compounds do not have the capacity to induce transcription of the luciferase gene. These compounds do not exert an androgenic effect on MDA-Kb2 cells in culture for the environmental concentrations tested. The addition of flutamide for the same tested concentrations of antifungal molecules reduces the luminescence induced by amphotericin B, econazole and miconazole, which is explained by a strong interaction of these molecules with flutamide which may have a greater toxic effect than when tested alone. The cytotoxicity test shows that econazole and ketoconazole can cause cell death at certain concentrations tested. This cell mortality is perhaps induced by a direct or indirect action on deoxyribonucleic acid (DNA), ribonucleic acid (RNA) or proteins necessary for cell division. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title="cytotoxicity">cytotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=androgenic%20potential" title=" androgenic potential"> androgenic potential</a>, <a href="https://publications.waset.org/abstracts/search?q=antifungals" title=" antifungals"> antifungals</a>, <a href="https://publications.waset.org/abstracts/search?q=MDA-Kb2" title=" MDA-Kb2"> MDA-Kb2</a> </p> <a href="https://publications.waset.org/abstracts/186088/cytotoxicity-and-androgenic-potential-of-antifungal-drug-substances-on-mda-kb2-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186088.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">48</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> A Rare Atypical Presentation of Iichthyosis Follicularis, Alopecia, and Photophobia Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20R.%20Apoorva">D. R. Apoorva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is a rare oculocutaneous disorder of genetic origin. This disorder results from mutations in the membrane-bound transcription factor protease site, two genes that impair cholesterol homeostasis, and the ability to cope with endoplasmic reticulum stress. We report a rare case of IFAP syndrome with an atypical presentation, and it was interesting to note that the child had patchy non-scarring alopecia over the scalp along with unilateral madarosis. To our best knowledge, this unique presentation has not been described earlier. The child presented with photophobia and unilateral ptosis. The child also had short stature and intellectual disability. Skin histopathology was nonspecific and consisted of dilated hair follicles with keratin plugs extending above the skin surface. This rare oculocutaneous disorder requires proper documentation so that identification of its variants may be possible in the future. Early recognition of atypical presentations can help in preventing cardiovascular complications, which remain the major cause of death. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alopecia" title="alopecia">alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=photophobia" title=" photophobia"> photophobia</a>, <a href="https://publications.waset.org/abstracts/search?q=ichthyosis%20follicularis" title=" ichthyosis follicularis"> ichthyosis follicularis</a>, <a href="https://publications.waset.org/abstracts/search?q=IFAP%20syndrome" title=" IFAP syndrome"> IFAP syndrome</a> </p> <a href="https://publications.waset.org/abstracts/152090/a-rare-atypical-presentation-of-iichthyosis-follicularis-alopecia-and-photophobia-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152090.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">79</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus Pyrethrum Dc</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vikas%20Sharma">Vikas Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20K.%20Dixit"> V. K. Dixit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Anacyclus pyrethrum (A. pyrethrum) has been used as Vajikaran Rasayana (aphrodisiac) in traditional Indian ayurvedic medicine to treat male sexual dysfunction, including infertility. Aphrodisiac activity may be due to an increase in the production or effect of androgens, so this study sought to evaluate the androgenic and spermatogenic potential of the alkylamide-rich ethanol solution extract. Male Wistar strain rats weighing between 150 and 180 g were completely randomized divided into five groups. The ethanol solution extract of A. pyrethrum was administered to groups of rats in 50, 100, and 150 mg/kg doses for a period of 28 days, and the action was compared with control and testosterone-treated rats. Thirteen N-alkylamides were detected in the extract by using HPLC/UV/electrospray ionization mass spectrometry method. Extract administration at all the doses produced significant increase in body weight, sperm count, motility, and viability along with serum testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations. Histoarchitecture of testis revealed increased spermatogenic activities. Seminal fructose content was also significantly increased after 28 days of treatment. Our results suggest that the ethanol solution extract of the roots of A. pyrethrum has androgenic potential and may improve male fertility by enhancing spermatogenesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=N-alkylamides" title="N-alkylamides">N-alkylamides</a>, <a href="https://publications.waset.org/abstracts/search?q=testosterone" title=" testosterone"> testosterone</a>, <a href="https://publications.waset.org/abstracts/search?q=Anacyclus%20pyrethrum" title=" Anacyclus pyrethrum"> Anacyclus pyrethrum</a>, <a href="https://publications.waset.org/abstracts/search?q=androgen" title=" androgen"> androgen</a> </p> <a href="https://publications.waset.org/abstracts/30545/androgenic-and-spermatogenic-activity-of-alkylamide-rich-ethanol-solution-extract-of-anacyclus-pyrethrum-dc" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30545.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">476</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> Monitoring of Endocrine Disruptors in Surface Waters and Sediment from the River Nile (Egypt) by Yeast Assays</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alaa%20G.%20M.%20Osman">Alaa G. M. Osman</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Y.%20AbouelFadl"> Khaled Y. AbouelFadl</a>, <a href="https://publications.waset.org/abstracts/search?q=Angela%20Kr%C3%BCger"> Angela Krüger</a>, <a href="https://publications.waset.org/abstracts/search?q=Werner%20Kloas"> Werner Kloas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In Egypt, no previous records are available regarding possible multiple hormonal activities in the aquatic systems and especially the river Nile. In this paper, the in vitro yeast estrogen screen (YES) and yeast androgen screen (YAS) were used to assess the multiple hormonal activities in surface waters and sediment from the Egyptian river Nile for the first time. This study sought to determine if river Nile water caused changes in gonadal histology of Nile tilapia (Oreochromis niloticus niloticus). All water samples exhibited extremely low levels of estrogenicity. Estrogenicity was not detected nearly in any of the sediment samples. Unlike the estrogenicity, significant androgenic activities were recorded in the water and sediment samples along the Nile course. The present study reports for the first time quantified anti-estrogenic and anti-androgenic activities with high levels in both water and sediment of the river Nile. The greatest anti-estrogenic and anti-androgenic activities were observed in sample from downstream river Nile. These results indicated that the anti-estrogenic and anti-androgenic activities along the Nile course were great and the pollution of the sites at the downstream was more serious than the upstream sites due to industrial activities at theses sites. Good correlations were observed among some hormonal activities, suggesting coexistence of these contaminants in the environmental matrices. There were no signs of sexual disruption in any of the gonads analysed from either male or female Nile tilapia, demonstrating that any hormonal activity present along the Nile course was not sufficient to induce adverse effects on reproductive development. Further investiga¬tion is necessary to identify the chemicals responsible for the hormonal activities in the river Nile and to examine the effect of very low levels of hormonally active chemicals on gonadal histology, as well as in the development of more sensitive biomarkers. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multiple%20hormonal%20activities" title="multiple hormonal activities">multiple hormonal activities</a>, <a href="https://publications.waset.org/abstracts/search?q=YES" title=" YES"> YES</a>, <a href="https://publications.waset.org/abstracts/search?q=YAS" title=" YAS"> YAS</a>, <a href="https://publications.waset.org/abstracts/search?q=river%20Nile" title=" river Nile"> river Nile</a>, <a href="https://publications.waset.org/abstracts/search?q=Nile%20tilapia" title=" Nile tilapia"> Nile tilapia</a>, <a href="https://publications.waset.org/abstracts/search?q=gonadal%20histology" title=" gonadal histology"> gonadal histology</a> </p> <a href="https://publications.waset.org/abstracts/16871/monitoring-of-endocrine-disruptors-in-surface-waters-and-sediment-from-the-river-nile-egypt-by-yeast-assays" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16871.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">483</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> The Study of Dissolving Microneedle Patch for Androgenetic Alopecia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Li-Yu%20Lee">Li-Yu Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Shuan%20Chen"> Yu-Shuan Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jun%20Sheng%20Wang"> Jun Sheng Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=I-Ming%20Chu"> I-Ming Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microneedle patch is a painless transdermal drug delivery method, It could solve some problems in traditional drug delivery such as digestive system causing drug metabolism and subcutaneous injection causing some side effects. Coating drug on or loading drug in microneedle can carry active ingredient through stratum corneum, also can control dose well when microneedle patch apply on localized topical area. We used hyaluronic acid to fabricate dissolvable microneedle patch and encapsulated minoxidil into microneedles. Minoxdil is a drug for exterior use that can be used to treat Androgenetic alopecia, but related commercial products have some shortcomings, for example, propylene glycol which is used to soften stratum corneum cause skin allergic reaction, comparing chemical promotion, microneedle patch provide physical way to make drugs through nature barrier of skin. In this research, we designed a two-step process to fabricate microneedle patch, that can effectively reduce drug waste, and gentle production process could maintain drug activity well. We also do in vitro test on cadaver to make sure patch has enough mechanical strength to penetrate stratum corneum. In the release test and animal test, we found microneedle patch has higher delivery efficiency than tradition way. In this study, we may determine that germinal MNs patch is a potential commodity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dissolving%20microneedles" title="dissolving microneedles">dissolving microneedles</a>, <a href="https://publications.waset.org/abstracts/search?q=androgenetic%20alopecia" title=" androgenetic alopecia"> androgenetic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=minoxidil" title=" minoxidil"> minoxidil</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery" title=" transdermal drug delivery"> transdermal drug delivery</a> </p> <a href="https://publications.waset.org/abstracts/66745/the-study-of-dissolving-microneedle-patch-for-androgenetic-alopecia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66745.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">279</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> Efficacy and Safety of Combination Therapy in Androgenetic Alopecia: Randomized Uncontrolled Evaluator, Blind Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shivani%20Dhande">Shivani Dhande</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjiv%20Choudhary"> Sanjiv Choudhary</a>, <a href="https://publications.waset.org/abstracts/search?q=Adarshlata%20Singh"> Adarshlata Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Early age of onset of baldness has marked psychological impact on personality. Combination therapies have better efficacy than monotherapy in androgenetic alopecia. Although medical, surgical treatment and cosmetic aids are available for treatment of pattern baldness, medical is first preferred the line of treatment. Although only 5% topical minoxidil is USFDA approved, 10% is available in India since 2007. Efficacy of tablet finasteride is well established in male pattern baldness. 5% topical minoxidil is effective and safe in female pattern baldness. There is a role of saw palmetto in regrowth of scalp hair. With this background research was undertaken to study efficacy and safety of topical minoxidil 10% + tab. Finesteride (1mg) + dermaroller in male pattern baldness and topical minoxidil 5% + cap. Saw palmetto (320 mg) + dermaroller in female pattern baldness. Methods and Materials: It was a randomized uncontrolled evaluator blind study consisting of total 21 patients, 15 of male pattern baldness and 6 of female pattern baldness within 20-35 yrs of age were enrolled. Male patients had Hamilton grade 2-4 MPB and females had Ludwig grade 2 FPB. Male patients were treated with Tab Finesteride 1mg once daily + 10% topical Minoxidil 1ml twice daily for 6 months. Female patients were treated with Cap. Saw palmetto 320 mg once daily + 5% topical Minoxidil twice daily for 6 months. In both male & female patients dermaroller therapy was used once in 10 days for 4 sittings followed by once in 15 days for next 5 months. Blood pressure and possible side effects were monitored in every follow up visits. Pre and post treatment photographs were taken. Assessment of hair growth was done at baseline and at the end of 6 months. Patients satisfactory grading scale and Physician assessment of hair growth scale were used to assessing the results. Trichoscan was done for assessment of hair-shaft diameter and density. Pre and post treatment photographs and Trichoscan hair growth analysis (by diameter and density) was done by physician (dermatologist) not directly involved in this study (evaluator blind). Result: This combination therapy showed moderate response in female pattern alopecia and good to excellent results in male pattern alopecia at the end of 6 months. During therapy none of the patients showed side effects like hypotension, headache and loss of libido, hirsuitism. Mild irritation due to crystal deposition was noted by 3 patients. Conclusion: Effective and early treatment using combination therapy with higher percent of Minoxidil for rapid hair growth is necessary in initial period since it will boost up the self-confidence in patients leading to better treatment compliance. Subsequent maintenance of hair growth can be done with lower concentration. No significant side effects with treatment are observed in both group of patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgenetic%20alopecia" title="androgenetic alopecia">androgenetic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=dermaroller" title=" dermaroller"> dermaroller</a>, <a href="https://publications.waset.org/abstracts/search?q=finasteride" title=" finasteride"> finasteride</a>, <a href="https://publications.waset.org/abstracts/search?q=minoxidil" title=" minoxidil"> minoxidil</a>, <a href="https://publications.waset.org/abstracts/search?q=saw%20palmetto" title=" saw palmetto"> saw palmetto</a> </p> <a href="https://publications.waset.org/abstracts/68880/efficacy-and-safety-of-combination-therapy-in-androgenetic-alopecia-randomized-uncontrolled-evaluator-blind-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68880.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">251</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> Folliculitis Decalvans: Update</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Alyoussef">Abdullah Alyoussef</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Folliculitis decalvans is a rare inflammatory scalp disorder. This paper gives an update to patient management and treatment modalities. Folliculitis decalvans is classified as primary neutrophilic cicatricial alopecia and predominantly occurs in middle-aged adults. The cause of folliculitis decalvans (FD) remains unknown. Staphylococcus aureus and a deficient host immune response seem to play an important role in the development of this disfiguring scalp disease. Lesions occur mainly in the vertex and occipital area. Clinically, the lesions present with follicular pustules, lack of ostia, diffuse and perifollicular erythema, follicular tufting, and, oftentimes, hemorrhagic crusts and erosions. Histology displays a mainly neutrophilic inflammatory infiltrate in early lesions and additionally lymphocytes and plasma cells in advanced lesions. Treatment is focused on the eradication of S. aureus and anti-inflammatory agents. Although the etiology of FD is unclear, S. aureus is almost always isolated from affected areas, and eradication is an important part of therapeutic management, in combination with systemic and ⁄ or topical anti-inflammatory treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cicatricial%20alopecia" title="cicatricial alopecia">cicatricial alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=folliculitis%20decalvans" title=" folliculitis decalvans"> folliculitis decalvans</a>, <a href="https://publications.waset.org/abstracts/search?q=tufted%20folliculitis" title=" tufted folliculitis"> tufted folliculitis</a>, <a href="https://publications.waset.org/abstracts/search?q=erosion" title=" erosion"> erosion</a> </p> <a href="https://publications.waset.org/abstracts/23424/folliculitis-decalvans-update" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23424.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">412</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> Ameliorative Effects of Ganoderma lucidum Extracts on Testosterone Induced Prostatic Hyperplasia in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alok%20Nahata">Alok Nahata</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Nowadays, androgen-mediated diseases such as prostate cancer, hirsutism, acne, androgenic alopecia and benign prostatic hyperplasia (BPH) have become serious problems. The aim of the present study was to find out whether Ganoderma lucidum (GL) can be used as a clinically effective medicine for the management of prostatic hyperplasia. Methodology: In vitro studies were conducted to assess the 5α-reductase inhibitory potential of GL. Testosterone (3 mg/kg s.c.) was administered to the rats along with the test extracts (10, 20 and 50 mg/kg p.o for a period of 28 days. Finasteride was used as a positive control (1 mg/kg p.o.). Major Findings: GL extracts attenuated the increase in the prostate/body weight ratio (P/BW) induced by testosterone. Most of the values were significant when compared to testosterone-treated group and finasteride treated groups. Petroleum ether extract (50 mg/kg p.o.) exhibited the best activity (P < 0.01). Ethanolic extract (20 and 50 mg/kg p.o.) also exhibited significant activity (P < 0.01). The urine output also improved significantly (P < 0.01 in all groups as compared to standard finasteride), which emphasize the clinical implications of the study. Testosterone levels measured weekly and prostate-specific antigen (PSA) levels measured at the end of the study also support the findings. Histological studies suggested improvement in prostatic histoarchitecture in extract-treated groups as compared to the testosterone-treated group. Conclusion: Study clearly reflects the utility of extracts in BPH. Because of conversion of testosterone to dihydrotestosterone, the prostate size is increased, thereby causing obstruction in urinary output. The observed effect that extracts do not allow the increase as reflected by urinary output, P/BW ratios and histoarchitecture showed that activity of administered testosterone was blocked by the extract and resulted in recovery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benign%20prostatic%20hyperplasia" title="benign prostatic hyperplasia">benign prostatic hyperplasia</a>, <a href="https://publications.waset.org/abstracts/search?q=Ganoderma%20lucidum" title=" Ganoderma lucidum"> Ganoderma lucidum</a>, <a href="https://publications.waset.org/abstracts/search?q=prostate-specific%20antigen" title=" prostate-specific antigen"> prostate-specific antigen</a>, <a href="https://publications.waset.org/abstracts/search?q=5%CE%B1-reductase" title=" 5α-reductase"> 5α-reductase</a>, <a href="https://publications.waset.org/abstracts/search?q=testosterone" title=" testosterone"> testosterone</a> </p> <a href="https://publications.waset.org/abstracts/89942/ameliorative-effects-of-ganoderma-lucidum-extracts-on-testosterone-induced-prostatic-hyperplasia-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89942.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> The Aesthetic Reconstruction of Post-Burn Eyebrow Alopecia with Bilateral Superficial Temporal Artery Island Scalp Flap</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kumar%20Y.">Kumar Y.</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20D."> Suman D.</a>, <a href="https://publications.waset.org/abstracts/search?q=Sumathi"> Sumathi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Burns to the face account for between one-fourth and one-third of all burns. The loss of an eyebrow due to a burn or infection can have negative physical and psychological consequences for patients because eyebrows have a critical functional and aesthetic role on the face. Plastic surgeons face unique challenges in reconstructing eyebrows due to their complex anatomy and variations within genders. As a general rule, there are three techniques for reconstructing the eyebrow: superficial temporal artery island flap, a composite graft from the scalp, and mini or micro follicular grafts from the scalp. In situations where a sufficient amount of subcutaneous tissue is not available and the defect is big such as the case of burns, flaps like the superficial temporal artery scalp flap remain reliable options. In 2018, a 17-year-old female patient presented to the department of Burns Plastic and reconstructive Surgery of Guru Teg Bahadur Hospital, Delhi, India. A scald-burn injury to the face occurred two years before admission, resulting in bilateral eyebrow loss. We reconstructed the bilateral eyebrows using bilateral scalp island flaps based on the posterior branch of the superficial temporal artery. The reconstructed eyebrows successfully assumed a desirable shape and exhibited a natural appearance, which was consistent with preoperative expectations and the patient stated that she was more comfortable with her social relationships. Among the current treatment procedures, the superficial temporal artery island flap continues to be a versatile option for reconstructing the eyebrows after alopecia, especially in cases of burns. Results: During the 30 days follow-up period, the scalp island flap remained vascularised with normal hair growth, without complications. The reconstructed eyebrows successfully assumed a desirable shape and exhibited a natural appearance; the patient stated that she was more comfortable with her social relationships. Conclusion: In this case report, we demonstrated how scalp island flaps pedicled by the superficial temporal artery could be performed very safely and reliably to create new eyebrows. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alopecia" title="alopecia">alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=burns" title=" burns"> burns</a>, <a href="https://publications.waset.org/abstracts/search?q=eyebrow" title=" eyebrow"> eyebrow</a>, <a href="https://publications.waset.org/abstracts/search?q=flap" title=" flap"> flap</a>, <a href="https://publications.waset.org/abstracts/search?q=superficial%20temporal%20artery" title=" superficial temporal artery"> superficial temporal artery</a> </p> <a href="https://publications.waset.org/abstracts/141949/the-aesthetic-reconstruction-of-post-burn-eyebrow-alopecia-with-bilateral-superficial-temporal-artery-island-scalp-flap" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141949.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">216</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> Endocrine Disruptors Effects on the 20-Hydroxyecdysone Concentration and the Vitellogenin Gene Expression in Gammarus sp.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eric%20Gismondi">Eric Gismondi</a>, <a href="https://publications.waset.org/abstracts/search?q=Aurelie%20Bigot-Clivot"> Aurelie Bigot-Clivot</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Endocrine disruptors (EDCs) are well known to disrupt the development and the reproduction of exposed organisms. Although this point has been studied in vertebrate models, the limited knowledge of the endocrine system of invertebrates makes the evaluation of EDCs effects difficult. However, invertebrates represent the major part of aquatic ecosystems, such as amphipods Gammaridea, which are crucial for their functioning (e.g., litter degradation, food resource). Moreover, gammarids are hosts of parasites such as vertically-transmitted microsporidia (microsporidia VT), which could be confounding factors in assessment of EDC effects. Indeed, some microsporidia VT could have endocrine effects by their own present in the host since it was observed for example, a feminization of juvenile males, which become phenotypic females. This work evaluated the impact of ethinylestradiol (EE₂, estrogenic), cyproterone acetate (CPA, anti-androgenic), 4-hydroxytamoxifen (4HT, anti-estrogenic) and 17α-methyltestosterone (17MT - androgenic), on the 20-hydroxyecdysone concentration (i.e. 20HE - molt process) and the vitellogenin gene expression (i.e. reproduction) in the freshwater amphipod Gammarus pulex, after a 96h laboratory exposure. In addition, the presence of microsporidia VT was verified in order to analyze the effect of this confounding factor. Results of this study shown that, although endocrine systems of invertebrates and vertebrates are different, EDCs proved in vertebrates could also affect biological functions hormonally controlled in invertebrates. Indeed, the molt process of crustaceans was disrupted in the first stage (i.e. 20-HE concentration) and therefore, could affect, at the long term, the population dynamic. In addition, it was observed that G. pulex was differently impacted according to the gender and parasitism, which underline the importance to take into account these confounding factors to better evaluate the EDCs impact on invertebrate populations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endocrine%20disruption" title="endocrine disruption">endocrine disruption</a>, <a href="https://publications.waset.org/abstracts/search?q=gammarus%20sp." title=" gammarus sp."> gammarus sp.</a>, <a href="https://publications.waset.org/abstracts/search?q=molt" title=" molt"> molt</a>, <a href="https://publications.waset.org/abstracts/search?q=parasitism" title=" parasitism"> parasitism</a> </p> <a href="https://publications.waset.org/abstracts/79158/endocrine-disruptors-effects-on-the-20-hydroxyecdysone-concentration-and-the-vitellogenin-gene-expression-in-gammarus-sp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79158.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">164</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Assessing the Clinicians’ Perspectives on Formulation with Minoxidil, Finasteride, and Capixyl™ in Androgenetic Alopecia: A Nationwide Dermatologist Survey</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sharma%20Aseem">Sharma Aseem</a>, <a href="https://publications.waset.org/abstracts/search?q=Dhurat%20Rachita"> Dhurat Rachita</a>, <a href="https://publications.waset.org/abstracts/search?q=Pawar%20Varsha"> Pawar Varsha</a>, <a href="https://publications.waset.org/abstracts/search?q=Khalse%20Manisha"> Khalse Manisha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Androgenetic alopecia (AGA) is a prevalent condition characterized by progressive hair thinning driven by genetic and androgen-related factors. The current FDA-approved treatments include oral finasteride and topical minoxidil, though many patients seek combination therapies to enhance results. This study aims to evaluate the effectiveness of a combination therapy involving Minoxidil, Finasteride, and Capixyl™ based on feedback from dermatologists. Methodology: A survey, validated by experts, was distributed to 29 leading dermatologists across India (in Tier 1 and 2 cities). The survey examined real-world clinical experiences, focusing on patient outcomes and the overall effectiveness of the mentioned formulation. Results: Among the surveyed dermatologists, 41.4% identified women aged 35-40 as the most frequently diagnosed with female pattern hair loss. The combination therapy with Minoxidil, Finasteride, and Capixyl™ was utilized by 34.5% of dermatologists for over 60 patients per month. The majority highlighted the benefits of this combination therapy, which acts via multiple mechanisms, such as vasodilation and dihydrotestosterone (DHT) receptor blockade, resulting in improved hair regrowth. Additionally, patients demonstrated better clinical outcomes, enhanced compliance, and fewer side effects. Demographically, younger patients, particularly those with AGA for less than 10 years, responded more positively to the treatment. Early intervention led to quicker and more significant results. Overall satisfaction among dermatologists was high, with 86.2% expressing positive feedback on the therapy. In terms of treatment outcomes, 51.7% of dermatologists observed visible results within 4-6 months, while 34.5% noticed a significant reduction in hair fall within 8-12 weeks. Improvements in scalp health were reported by 48.3%, and 51.7% saw an increased hair density within 3-4 months. Despite mild side effects such as scalp irritation, dryness, flaking, and occasional issues like folliculitis, headaches, itching, and redness, patient satisfaction remained high. Dermatologists reported that 93.1% of patients experienced faster and better hair regrowth with Capixyl™ compared to Minoxidil alone. Suggestions for improving the formulation included incorporating peptides like Saw Palmetto and enhancing product packaging to better meet patient needs. Discussion: The combination of Minoxidil, Finasteride, and Capixyl™ yielded positive clinical outcomes, especially in improving hair density, scalp health, and overall patient satisfaction. Dermatologists found that Capixyl™ peptides enhanced the therapeutic effect, promoting hair regrowth and improving compliance. While side effects were generally mild, there were suggestions to further improve the formulation by adding additional peptides like Saw Palmetto. Conclusion: The combination of Minoxidil and Finasteride fortified with Capixyl™ presents a promising therapeutic option for managing AGA. Dermatologists reported significant improvements in hair density, scalp health, and patient satisfaction. With its favorable efficacy and manageable side effects, this formulation proves to be a valuable addition to the treatment landscape for AGA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgenetic%20alopecia" title="androgenetic alopecia">androgenetic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=combination%20therapy" title=" combination therapy"> combination therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=minoxidil" title=" minoxidil"> minoxidil</a>, <a href="https://publications.waset.org/abstracts/search?q=finasteride" title=" finasteride"> finasteride</a>, <a href="https://publications.waset.org/abstracts/search?q=capixyl" title=" capixyl"> capixyl</a> </p> <a href="https://publications.waset.org/abstracts/193209/assessing-the-clinicians-perspectives-on-formulation-with-minoxidil-finasteride-and-capixyl-in-androgenetic-alopecia-a-nationwide-dermatologist-survey" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193209.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">13</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> Investigating the Successes of in vitro Embryogenesis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zelikha%20Labbani">Zelikha Labbani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The in vitro isolated microspore culture is the most powerful androgenic pathway to produce doubled haploid plants in the short time. To deviate a microspore toward embryogenesis, a number of factors, different for each species, must concur at the same time and place. Once induced, the microspore undergoes numerous changes at different levels, from overall morphology to gene expression. Induction of microspore embryogenesis not only implies the expression of an embryogenic program, but also a stress-related cellular response and a repression of the gametophytic program to revert the microspore to a totipotent status. As haploid single cells, microspore became a strategy to achieve various objectives particularly in genetic engineering. In this communication we would show the most recent advances in the producing haploid embryos via in vitro isolated microspore culture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20isolated%20microspore%20culture" title="in vitro isolated microspore culture">in vitro isolated microspore culture</a>, <a href="https://publications.waset.org/abstracts/search?q=success" title=" success"> success</a>, <a href="https://publications.waset.org/abstracts/search?q=haploid%20cells" title=" haploid cells"> haploid cells</a>, <a href="https://publications.waset.org/abstracts/search?q=bioinformatics" title=" bioinformatics"> bioinformatics</a>, <a href="https://publications.waset.org/abstracts/search?q=biomedicine" title=" biomedicine"> biomedicine</a> </p> <a href="https://publications.waset.org/abstracts/9122/investigating-the-successes-of-in-vitro-embryogenesis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9122.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">475</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> Successes on in vitro Isolated Microspores Embryogenesis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zelikha%20Labbani">Zelikha Labbani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The In Vitro isolated micro spore culture is the most powerful androgenic pathway to produce doubled haploid plants in the short time. To deviate a micro spore toward embryogenesis, a number of factors, different for each species, must concur at the same time and place. Once induced, the micro spore undergoes numerous changes at different levels, from overall morphology to gene expression. Induction of micro spore embryogenesis not only implies the expression of an embryogenic program, but also a stress-related cellular response and a repression of the gametophytic program to revert the microspore to a totipotent status. As haploid single cells, micro spore became a strategy to achieve various objectives particularly in genetic engineering. In this study we would show the most recent advances in the producing haploid embryos via In Vitro isolated micro spore culture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=haploid%20cells" title="haploid cells">haploid cells</a>, <a href="https://publications.waset.org/abstracts/search?q=In%20Vitro%20isolated%20microspore%20culture" title=" In Vitro isolated microspore culture"> In Vitro isolated microspore culture</a>, <a href="https://publications.waset.org/abstracts/search?q=success" title=" success"> success</a> </p> <a href="https://publications.waset.org/abstracts/26693/successes-on-in-vitro-isolated-microspores-embryogenesis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26693.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">615</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> Efficient Method for Inducing Embryos from Isolated Microspores of Durum Wheat</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zelikha%20Labbani">Zelikha Labbani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Durum wheat represents an attractive species to study androgenesis via isolated microspore culture in order to increase the efficiency of androgenic yield in recalcitrant species such as in induction embryogenesis. We describe here an efficient method for inducing embryos from isolated microspores of durum wheat. It is shown that this method, associated with cold alone or cold plus mannitol pretreatment, or mannitol alone of the spikes kept within their sheath leaves during different times, has significant positive effects on embryo production. The aim of this study was, therefore, to test the effect of mannitol 0,3M and cold pretreatment on the quality and quantity of embryos produced from microspore culture from wheat cultivars. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20embryogenesis" title="in vitro embryogenesis">in vitro embryogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=isolated%20microspores%20culture" title=" isolated microspores culture"> isolated microspores culture</a>, <a href="https://publications.waset.org/abstracts/search?q=durum%20wheat" title=" durum wheat"> durum wheat</a>, <a href="https://publications.waset.org/abstracts/search?q=pretreatments" title=" pretreatments"> pretreatments</a>, <a href="https://publications.waset.org/abstracts/search?q=mannitol%200.3m" title=" mannitol 0.3m"> mannitol 0.3m</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20pretreatment" title=" cold pretreatment"> cold pretreatment</a> </p> <a href="https://publications.waset.org/abstracts/184559/efficient-method-for-inducing-embryos-from-isolated-microspores-of-durum-wheat" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184559.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">57</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> Machine Learning for Feature Selection and Classification of Systemic Lupus Erythematosus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Zidoum">H. Zidoum</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20AlShareedah"> A. AlShareedah</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Al%20Sawafi"> S. Al Sawafi</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Al-Ansari"> A. Al-Ansari</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Al%20Lawati"> B. Al Lawati</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic and environmental components. SLE is characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares. Despite recent progress in classification tools, the early diagnosis of SLE is still an unmet need for many patients. This study proposes an interpretable disease classification model that combines the high and efficient predictive performance of CatBoost and the model-agnostic interpretation tools of Shapley Additive exPlanations (SHAP). The CatBoost model was trained on a local cohort of 219 Omani patients with SLE as well as other control diseases. Furthermore, the SHAP library was used to generate individual explanations of the model's decisions as well as rank clinical features by contribution. Overall, we achieved an AUC score of 0.945, F1-score of 0.92 and identified four clinical features (alopecia, renal disorders, cutaneous lupus, and hemolytic anemia) along with the patient's age that was shown to have the greatest contribution on the prediction. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=feature%20selection" title="feature selection">feature selection</a>, <a href="https://publications.waset.org/abstracts/search?q=classification" title=" classification"> classification</a>, <a href="https://publications.waset.org/abstracts/search?q=systemic%20lupus%20erythematosus" title=" systemic lupus erythematosus"> systemic lupus erythematosus</a>, <a href="https://publications.waset.org/abstracts/search?q=model%20interpretation" title=" model interpretation"> model interpretation</a>, <a href="https://publications.waset.org/abstracts/search?q=SHAP" title=" SHAP"> SHAP</a>, <a href="https://publications.waset.org/abstracts/search?q=Catboost" title=" Catboost"> Catboost</a> </p> <a href="https://publications.waset.org/abstracts/163565/machine-learning-for-feature-selection-and-classification-of-systemic-lupus-erythematosus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163565.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">84</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> Metabolic Changes during Reprogramming of Wheat and Triticale Microspores</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Natalia%20Hordynska">Natalia Hordynska</a>, <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Szechynska-Hebda"> Magdalena Szechynska-Hebda</a>, <a href="https://publications.waset.org/abstracts/search?q=Miroslaw%20Sobczak"> Miroslaw Sobczak</a>, <a href="https://publications.waset.org/abstracts/search?q=Elzbieta%20Rozanska"> Elzbieta Rozanska</a>, <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Troczynska"> Joanna Troczynska</a>, <a href="https://publications.waset.org/abstracts/search?q=Zofia%20Banaszak"> Zofia Banaszak</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Wedzony"> Maria Wedzony</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Albinism is a common problem encountered in wheat and triticale breeding programs, which require in vitro culture steps e.g. generation of doubled haploids via androgenesis process. Genetic factor is a major determinant of albinism, however, environmental conditions such as temperature and media composition influence the frequency of albino plant formation. Cold incubation of wheat and triticale spikes induced a switch from gametophytic to sporophytic development. Further, androgenic structures formed from anthers of the genotypes susceptible to androgenesis or treated with cold stress, had a pool of structurally primitive plastids, with small starch granules or swollen thylakoids. High temperature was a factor inducing andro-genesis of wheat and triticale, but at the same time, it was a factor favoring the formation of albino plants. In genotypes susceptible to albinism or after heat stress conditions, cells formed from anthers were vacuolated, and plastids were eliminated. Partial or complete loss of chlorophyll pigments and incomplete differentiation of chloroplast membranes result in formation of tissues or whole plant unable to perform photosynthesis. Indeed, susceptibility to the andro-genesis process was associated with an increase of total concentration of photosynthetic pigments in anthers, spikes and regenerated plants. The proper balance of the synthesis of various pigments, was the starting point for their proper incorporation into photosynthetic membranes. In contrast, genotypes resistant to the androgenesis process and those treated with heat, contained 100 times lower content of photosynthetic pigments. In particular, the synthesis of violaxanthin, zeaxanthin, lutein and chlorophyll b was limited. Furthermore, deregulation of starch and lipids synthesis, which led to the formation of very complex starch granules and an increased number of oleosomes, respectively, correlated with the reduction of the efficiency of androgenesis. The content of other sugars varied depending on the genotype and the type of stress. The highest content of various sugars was found for genotypes susceptible to andro-genesis, and highly reduced for genotypes resistant to androgenesis. The most important sugars seem to be glucose and fructose. They are involved in sugar sensing and signaling pathways, which affect the expression of various genes and regulate plant development. Sucrose, on the other hand, seems to have minor effect at each stage of the androgenesis. The sugar metabolism was related to metabolic activity of microspores. The genotypes susceptible to androgenesis process had much faster mitochondrium- and chloroplast-dependent energy conversion and higher heat production by tissues. Thus, the effectiveness of metabolic processes, their balance and the flexibility under the stress was a factor determining the direction of microspore development, and in the later stages of the androgenesis process, a factor supporting the induction of androgenic structures, chloroplast formation and the regeneration of green plants. The work was financed by Ministry of Agriculture and Rural Development within Program: ‘Biological Progress in Plant Production’, project no HOR.hn.802.15.2018. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgenesis" title="androgenesis">androgenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=chloroplast" title=" chloroplast"> chloroplast</a>, <a href="https://publications.waset.org/abstracts/search?q=metabolism" title=" metabolism"> metabolism</a>, <a href="https://publications.waset.org/abstracts/search?q=temperature%20stress" title=" temperature stress"> temperature stress</a> </p> <a href="https://publications.waset.org/abstracts/93448/metabolic-changes-during-reprogramming-of-wheat-and-triticale-microspores" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93448.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">260</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Region-Specific Secretory Protein, α2M, in Male Reproductive Tract of the Blue Crab And Its Dynamics during Sperm transit towards Female Spermatheca</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Thanyaporn%20Senarai">Thanyaporn Senarai</a>, <a href="https://publications.waset.org/abstracts/search?q=Rapeepun%20Vanichviriyakit"> Rapeepun Vanichviriyakit</a>, <a href="https://publications.waset.org/abstracts/search?q=Shinji%20Miyata"> Shinji Miyata</a>, <a href="https://publications.waset.org/abstracts/search?q=Chihiro%20Sato"> Chihiro Sato</a>, <a href="https://publications.waset.org/abstracts/search?q=Prapee%20Sretarugsa"> Prapee Sretarugsa</a>, <a href="https://publications.waset.org/abstracts/search?q=Wattana%20Weerachatyanukul"> Wattana Weerachatyanukul</a>, <a href="https://publications.waset.org/abstracts/search?q=Ken%20Kitajima"> Ken Kitajima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, we characterized a region-specific 250 kDa protein that was secreted of MSD fluid, which is believed to play dual functions in forming a spermatophoric wall for sperm physical protection, and in sperm membrane modification as part of sperm maturation process. The partial amino acid sequence and N-terminal sequencing revealed that the MSD-specific 250 kDa protein showed a high similarity with a plasma-rich protein, α-2 macroglobulin (α2M), so termed pp-α2M. This protein was a large glycoprotein contained predominantly mannose and GlcNAc. The expression of pp-α2M mRNA was detected in spermatic duct (SD), androgenic gland (AG) and hematopoietic tissue, while the protein expression was rather specific to the apical cytoplasm of MSD epithelium. The secretory pp-α2M in MSD fluid was acquired onto the MSD sperm membrane and was also found within the matrix of the acrosome. Distally, pp-α2M was removed from spermathecal sperm membrane, while its level kept constant in the sperm AC. Together the results indicate that pp-α2M is a 250 kDa region-specific secretory protein which plays roles in sperm physical protection and also acts as maturation factor in the P. pelagicus sperm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alpha-2%20macroglobulin" title="alpha-2 macroglobulin">alpha-2 macroglobulin</a>, <a href="https://publications.waset.org/abstracts/search?q=blue%20swimming%20crab" title=" blue swimming crab"> blue swimming crab</a>, <a href="https://publications.waset.org/abstracts/search?q=sperm%20maturation" title=" sperm maturation"> sperm maturation</a>, <a href="https://publications.waset.org/abstracts/search?q=spermatic%20duct" title=" spermatic duct "> spermatic duct </a> </p> <a href="https://publications.waset.org/abstracts/60090/region-specific-secretory-protein-a2m-in-male-reproductive-tract-of-the-blue-crab-and-its-dynamics-during-sperm-transit-towards-female-spermatheca" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60090.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> Evaluation on Estrogenic Effects of Diisononyl Adipate (DiNA) on MCF-7 Human Breast Cancer Cell Lines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shih-cheng%20Li">Shih-cheng Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Ming-Yi%20Chung"> Ming-Yi Chung</a>, <a href="https://publications.waset.org/abstracts/search?q=Mei-Lien%20Chen"> Mei-Lien Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Plasticizers, such as phthalates and adipates, were substances added to a material that provided flexibility and durability to plastics such as polyvinyl chloride (PVC). Phthalates were generally recognized as an endocrine disrupter due to their estrogenic and anti-androgenic activities. Phthalates had the capacity to bind to estrogen receptors, and hence they might prolong menstrual cycles and increase the proportion of premature menopause. Recently, adipates such as di-2-ethylhexyl adipate (DEHA) and di-isononyl adipate (DiNA) had replaced phthalates and were now used for food packaging. Methods: MCF-7 cell lines were treated with di-2-ethylhexyl phthalate (DEHP), di- 2-ethylhexyl adipate (DEHA), or di-isononyl adipate (DiNA) (10-6 , 10-5 , and 10-4 mol/l), using 17β-estradiol (10-8 mol/l) as a positive control. After incubations of 24, 48, 72, and 96 hours, the cells were tested using the alamarBlue assay. Results: The alamarBlue assay revealed that cell proliferation significantly increased after treatments of DEHP and DEHA for 24 hours at a concentration of 10-6, 10-5, and 10-4 mol/l. After more than 48 hours, cell proliferations in DEHP at 10-6, 10-5, and 10-4 mol/l significantly decreased compared to the control group. Conclusions: The present study demonstrates that adipates, as well as phthalates, were capable of inducing cell proliferation. We further used MDA-MB-231 cell lines to confirm that the proliferation effect was generated through binding to estrogen receptors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MCF-7" title="MCF-7">MCF-7</a>, <a href="https://publications.waset.org/abstracts/search?q=phthalate" title=" phthalate"> phthalate</a>, <a href="https://publications.waset.org/abstracts/search?q=adipate" title=" adipate"> adipate</a>, <a href="https://publications.waset.org/abstracts/search?q=endocrine%20disrupter" title=" endocrine disrupter"> endocrine disrupter</a> </p> <a href="https://publications.waset.org/abstracts/42355/evaluation-on-estrogenic-effects-of-diisononyl-adipate-dina-on-mcf-7-human-breast-cancer-cell-lines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42355.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">296</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Effects of Boldenone Injections and Endurance Exercise on Hepatocyte Morphologic Damages in Male Wistar Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seyyed%20Javad%20Ziaolhagh">Seyyed Javad Ziaolhagh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: The purpose of present study was to investigate, the effects of anabolic steroid Boldenone (BOL) with eight weeks of resistance training on structural changes in rat liver. Method: 21 Male adult Wistar rats, 12 weeks old and 228/53±7/94 g initial body weight were randomly assigned to three groups: group1: Control+ Placebo (C), group2: training+ Placebo (T), group3: Boldenone intramuscular injections 5mg/kg (B). The endurance training protocol consisted three exercise sessions weekly started by a 30-minute run with the speed of 12 m/min and lasted by 60min run with the speed of 30 m/min in 8 weeks. At the end of the experiment, for light microscopic study Slides were prepared. Results: Sections stained of rat's livers showed no any cell degeneration and cytoplasmic lipid vacuoles in all groups, but few samples were seen. Indeed, congested blood sinusoids, cell infiltration and degeneration were seen in the Boldenone-treated group. Hepatotoxic effects were severe in group treatment received 5 mg/kg and directly depended on the doses. Indeed, training group was no any hepatocyte degeneration, inflammation and congestion. Conclusion: The present results showed that BOL has a marked adverse effect on the liver tissue, even with low– dose and endurance training. As a result, athletes should aware of Boldenone dosage consumption. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anabolic%20androgenic%20steroids" title="anabolic androgenic steroids">anabolic androgenic steroids</a>, <a href="https://publications.waset.org/abstracts/search?q=Boldenone" title=" Boldenone"> Boldenone</a>, <a href="https://publications.waset.org/abstracts/search?q=blood%20congestion" title=" blood congestion"> blood congestion</a>, <a href="https://publications.waset.org/abstracts/search?q=cellular%20inflammation" title=" cellular inflammation"> cellular inflammation</a>, <a href="https://publications.waset.org/abstracts/search?q=cellular%20degeneration" title=" cellular degeneration"> cellular degeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid%20vocuolations" title=" lipid vocuolations"> lipid vocuolations</a>, <a href="https://publications.waset.org/abstracts/search?q=endurance%20training" title=" endurance training"> endurance training</a> </p> <a href="https://publications.waset.org/abstracts/35964/effects-of-boldenone-injections-and-endurance-exercise-on-hepatocyte-morphologic-damages-in-male-wistar-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35964.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">430</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Comparative Analysis of the Psychosocial Impact of Skin Diseases in India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Priyanka%20Jain">Priyanka Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Sushila%20Pareek"> Sushila Pareek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Skin disease is often considered to be ‘only cosmetic’ by many medical professionals and lay-people alike but unlike most internal illnesses, skin disease is often immediately visible to others and therefore people suffering from dermatological conditions may suffer serious social and emotional consequences. The purpose of this research was to compare patients suffering from acne, alopecia areata (AA) and melanosis on perceived stress, social appearance anxiety and coping. The study included 120 patients (acne = 40 AA = 40 melanosis = 40) ages ranged from 15 to 25 years. Perceived Stress Scale (PSS), Social Appearance Anxiety Scale (SAAS), and The Brief COPE were administered to the patients. Analytical evaluation was done by Kruskal Wallis and ANOVA-tests. The results of the present study clearly revealed that perceived stress and social appearance anxiety were highest in patients with AA followed by acne patients and found least in patients with melanosis. With regard to coping, self-distraction as a coping technique was found highest in patients suffering from AA followed by acne and then melanosis. Denial was highest in acne patients followed by AA and experienced least by patients with melanosis. Behavioural disengagement was almost equal in patients with melanosis and acne and a little less in patients suffering from AA Acceptance was highest in patients with melanosis, followed by AA and least in acne patients. Self-blame was found highest in patients with acne, followed by AA patients further followed by patients suffering from melanosis. This study is an attempt to stimulate professionals working in the field of dermatology and mental health to explore their supportive communication and increase awareness regarding the difficulties that patients with skin disease can face. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=coping" title="coping">coping</a>, <a href="https://publications.waset.org/abstracts/search?q=dermatology" title=" dermatology"> dermatology</a>, <a href="https://publications.waset.org/abstracts/search?q=perceived%20stress" title=" perceived stress"> perceived stress</a>, <a href="https://publications.waset.org/abstracts/search?q=psychosocial%20impact" title=" psychosocial impact"> psychosocial impact</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20appearance%20anxiety" title=" social appearance anxiety"> social appearance anxiety</a> </p> <a href="https://publications.waset.org/abstracts/29427/comparative-analysis-of-the-psychosocial-impact-of-skin-diseases-in-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29427.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">472</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Pharmacological Activities and Potential Uses of Cyperus Rotundus: A Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arslan%20Masood%20Pirzada">Arslan Masood Pirzada</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Naeem"> Muhammad Naeem</a>, <a href="https://publications.waset.org/abstracts/search?q=Hafiz%20Haider%20Ali"> Hafiz Haider Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Latif"> Muhammad Latif</a>, <a href="https://publications.waset.org/abstracts/search?q=Aown%20Sammar%20Raza"> Aown Sammar Raza</a>, <a href="https://publications.waset.org/abstracts/search?q=Asad%20Hussain%20Bukhari"> Asad Hussain Bukhari</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Saqib"> Muhammad Saqib</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Ijaz"> Muhammad Ijaz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cyperus rotundus (Cyperaceae), a medicinal herb, is being traditionally used as a home remedy for the treatment of various clinical conditions like diarrhea, diabetic, pyretic, inflammation, malaria, and for treating stomach and bowel disorders. Its current status is one of the most widespread, troublesome, and economically damaging agronomic weeds, growing wildly in various tropical and sub-tropical regions of the world. Tuber and rhizomes of Cyperus rotundus possess a higher concentration of active ingredients in the form of essential oils, phenolic acids, ascorbic acids and flavonoids, responsible for its remedial properties. Exploitation of any medicinal plant application depends on the crucial and comprehensive information about the therapeutic potential of a plant. Researchers have evaluated and characterized the significance of Cyperus rotundus as an anti-androgenic, anti-bacterial, anti-cancerous, anti-convulsant, anti-diabetic, anti-diarrheal, anti-genotoxic, anti-inflammatory, anti-lipidemic, anti-malarial, anti-mutagenic, anti-obesity, anti-oxidant, anti-uropathogenic, hepato-, cardio-, neuroprotective, and nootropic agent. This paper comprises a broad review to summarize the current state of knowledge about chemical constituents, potential economic uses and therapeutic aspects of Cyperus rotundus that will aid in the development of bioethanol and modern herbal medicine through latest technologies that will promote the ability of this plant in the cure of many clinical disorders. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=purple%20nutsedge" title="purple nutsedge">purple nutsedge</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20composition" title=" chemical composition"> chemical composition</a>, <a href="https://publications.waset.org/abstracts/search?q=economic%20uses" title=" economic uses"> economic uses</a>, <a href="https://publications.waset.org/abstracts/search?q=therapeutic%20values" title=" therapeutic values"> therapeutic values</a>, <a href="https://publications.waset.org/abstracts/search?q=future%20directions" title=" future directions"> future directions</a> </p> <a href="https://publications.waset.org/abstracts/23922/pharmacological-activities-and-potential-uses-of-cyperus-rotundus-a-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23922.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">513</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Cell-Based and Exosome Treatments for Hair Restoration</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Armin%20Khaghani%20Boroujeni">Armin Khaghani Boroujeni</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Dehghani"> Leila Dehghani</a>, <a href="https://publications.waset.org/abstracts/search?q=Parham%20Talebi%20Boroujeni"> Parham Talebi Boroujeni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sahar%20Rostamian"> Sahar Rostamian</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Asilian"> Ali Asilian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Hair loss is a common complaint observed in both genders. Androgenetic alopecia is known pattern for hair loss. To assess new regenerative strategies (PRP, A-SC-BT, conditioned media, exosome-based treatments) compared to conventional therapies for hair loss or hair regeneration, an updated review was undertaken. To address this issue, we carried out this systematic review to comprehensively evaluate the efficacy of cell-based therapies on hair loss. Methods: The available online databases, including ISI Web of Science, Scopus, and PubMed, were searched systematically up to February 2022. The quality assessment of included studies was done using the Cochrane Collaboration's tool. Results: As a result, a total of 90 studies involving 2345 participants were included in the present study. The enrolled studies were conducted between 2010 and 2022. The subjects’ mean age ranged from 19 to 55.11 years old. Approaches using platelet rich plasma (PRP) provide a beneficial impact on hair regrowth. However, other cell-based therapies, including stem cell transplant, stem cell-derived conditioned medium, and stem cell-derived exosomes, revealed conflicting evidence. Conclusion: However, cell-based therapies for hair loss are still in their infancy, and more robust clinical studies are needed to better evaluate their mechanisms of action, efficacy, safety, benefits, and limitations. In this review, we provide the resources to the latest clinical studies and a more detailed description of the latest clinical studies concerning cell-based therapies in hair loss. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cell-based%20therapy" title="cell-based therapy">cell-based therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=exosome" title=" exosome"> exosome</a>, <a href="https://publications.waset.org/abstracts/search?q=hair%20restoration" title=" hair restoration"> hair restoration</a>, <a href="https://publications.waset.org/abstracts/search?q=systematic%20review" title=" systematic review"> systematic review</a> </p> <a href="https://publications.waset.org/abstracts/147922/cell-based-and-exosome-treatments-for-hair-restoration" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/147922.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">75</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Sexually Dimorphic Effects of Chronic Exercise and Myocytic Androgen Receptor Overexpression on Body Composition in Sprague dawley Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sabrina%20Barsky">Sabrina Barsky</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashley%20Monks"> Ashley Monks</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In humans, exercise improves symptoms of various pathological states, although exercise adaptations seem to differ in response to sex. Skeletal muscle anabolism is thought to be regulated by androgen receptor (AR) through poorly specified mechanisms. Interactions of AR and exercise on muscle phenotype remain inconclusive in males, and undetermined in females. We hypothesized that sex differences in exercise adaptations are regulated by the androgenic system and the type of exercise performed. Here we examined interactions between a muscle-specific AR overexpression transgene (HSA-AR) and forced aerobic exercise paradigm on muscle and adipose exercise adaptation in male and female rats. We used dual-energy X-ray absorptiometry (DXA) to examine body composition adaptations post 9-week exercise protocol. We replicated the effects of HSA-AR on body composition, with males only having increased % lean mass and reduced % fat mass (P<0.05). Aerobic exercise improved lean body phenotype significantly, with lesser indices of total and % fat mass (P<0.01) in both sexes. Sex-specific effects of exercise included decreased total body mass (P<0.01) in males and increased lean mass % (P<0.001) in females. Surprisingly, neither AR manipulation nor exercise affected bone parameters in either sex. This varied response in total mass and lean mass according to exercise presents a sexually dimorphic response to exercise. Neither sex showed an interaction between HSA-AR and forced aerobic exercise on body composition. Future work is proposed to examine the effects of exercise type (aerobic versus resistance) and the role of gonadal androgens in sexually dimorphic exercise-mediated mitochondrial adaptations. This work implicates the development of sex-specific exercise therapies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgen%20receptor" title="androgen receptor">androgen receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=forced%20exercise" title=" forced exercise"> forced exercise</a>, <a href="https://publications.waset.org/abstracts/search?q=muscle%20physiology" title=" muscle physiology"> muscle physiology</a>, <a href="https://publications.waset.org/abstracts/search?q=sexual%20dimorphism" title=" sexual dimorphism"> sexual dimorphism</a> </p> <a href="https://publications.waset.org/abstracts/105108/sexually-dimorphic-effects-of-chronic-exercise-and-myocytic-androgen-receptor-overexpression-on-body-composition-in-sprague-dawley-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/105108.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">125</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Oxidative and Hormonal Disruptions Underlie Bisphenol A: Induced Testicular Toxicity in Male Rabbits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kadry%20M.%20Sadek">Kadry M. Sadek</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20K.%20Abouzed"> Tarek K. Abouzed</a>, <a href="https://publications.waset.org/abstracts/search?q=Mousa%20A.%20Ayoub"> Mousa A. Ayoub</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The presence of endocrine-disrupting compounds, such as bisphenol A (BPA), in the environment can cause serious health problems. However, there are controversial opinions. This study investigated the reproductive, metabolic, oxidative and immunologic-disrupting effects of bisphenol A in male rabbits. Rabbits were divided into five groups. The first four rabbit groups were administered oral BPA (1, 10, 50, or 100 mg/kg/day) for ten weeks. The fifth group was administered corn oil as the vehicle. BPA significantly decreased serum testosterone, estradiol and the free androgen index (FAI) and significantly increased sex hormone binding globulin (SHBG) compared with the placebo group. The higher doses of BPA showed a significant decrease in follicular stimulating hormone (FSH) and luteinizing hormone (LH). A significant increase in blood glucose levels was identified in the BPA groups. The non-significant difference in insulin levels is a novel finding. The cumulative testicular toxicity of BPA was clearly demonstrated by the dose-dependent decrease in absolute testes weight, primary measures of semen quality and a significant increase in testicular malonaldehyde (MDA). Moreover, BPA significantly decreased total antioxidant capacity (TAC) and significantly increased immunoglobulin G (IgG) at the highest concentration. Our results suggest that BPA, especially at higher doses, is associated with many adverse effects on metabolism, oxidative stress, immunity, sperm quality and markers of androgenic action. These results may reflect the estrogenic effects of BPA, which we hypothesize could be related, in part, to an inhibitory effect on testicular steroidogenesis. The induction of oxidative stress by BPA may play an additional role in testicular toxicity. These results suggest that BPA poses a threat to endocrine and reproductive functions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bisphenol%20A" title="bisphenol A">bisphenol A</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=rabbits" title=" rabbits"> rabbits</a>, <a href="https://publications.waset.org/abstracts/search?q=semen%20quality" title=" semen quality"> semen quality</a>, <a href="https://publications.waset.org/abstracts/search?q=steroidogenesis" title=" steroidogenesis"> steroidogenesis</a> </p> <a href="https://publications.waset.org/abstracts/14594/oxidative-and-hormonal-disruptions-underlie-bisphenol-a-induced-testicular-toxicity-in-male-rabbits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> The Hair Growth Effects of Undariopsis peterseniana</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jung-Il%20Kang">Jung-Il Kang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeon%20Eon%20Park"> Jeon Eon Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Jin%20Moon"> Yu-Jin Moon</a>, <a href="https://publications.waset.org/abstracts/search?q=Young-Seok%20Ahn"> Young-Seok Ahn</a>, <a href="https://publications.waset.org/abstracts/search?q=Eun-Sook%20Yoo"> Eun-Sook Yoo</a>, <a href="https://publications.waset.org/abstracts/search?q=Hee-Kyoung%20Kang"> Hee-Kyoung Kang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study was conducted to evaluate the effect of Undariopsis peterseniana, a seaweed native to Jeju Island, Korea, on the growth of hair. The dermal papilla cells (DPCs) have known to regulate hair growth cycle and length of hair follicle through interact with epithelial cells. When immortalized vibrissa DPCs were treated with the U. peterseniana extract, the U. peterseniana extract significantly increased the proliferation of DPCs. The effect of U. peterseniana extract on the growth of vibrissa follicles was also examined. U. peterseniana extract significantly increased the hair-fiber lengths of the vibrissa follicles. Hair loss is partly caused by dihydrotestosterone (DHT) binding to androgen receptor in hair follicles, and the inhibition of 5α-reductase activity can prevent hair loss through the decrease of DHT level. The U. peterseniana extract inhibited 5α-reductase activity. Minoxidil, a potent hair-growth agent, can induce proliferation in NIH3T3 fibroblasts by opening KATP channels. We thus examined the proliferative effects of U. peterseniana extract in NIH3T3 fibroblasts. U. peterseniana extract significantly increased the proliferation of NIH3T3 fibroblasts. Tetraethylammonium chloride (TEA), a K+ channel blocker, inhibited U. peterseniana-induced proliferation in NIH3T3 fibroblasts. These results suggest that U. peterseniana could have the potential to treat alopecia through the proliferation of DPCs, the inhibition of 5α-reductase activity and the opening of KATP channels. [Acknowledgement] This research was supported by The Leading Human Resource Training Program of Regional Neo industry through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning (2016H1D5A1908786). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hair%20growth" title="hair growth">hair growth</a>, <a href="https://publications.waset.org/abstracts/search?q=Undariopsis%20peterseniana" title=" Undariopsis peterseniana"> Undariopsis peterseniana</a>, <a href="https://publications.waset.org/abstracts/search?q=vibrissa%20follicles" title=" vibrissa follicles"> vibrissa follicles</a>, <a href="https://publications.waset.org/abstracts/search?q=dermal%20papilla%20cells" title=" dermal papilla cells"> dermal papilla cells</a>, <a href="https://publications.waset.org/abstracts/search?q=5%CE%B1-reductase" title=" 5α-reductase"> 5α-reductase</a>, <a href="https://publications.waset.org/abstracts/search?q=KATP%20channels" title=" KATP channels"> KATP channels</a> </p> <a href="https://publications.waset.org/abstracts/55831/the-hair-growth-effects-of-undariopsis-peterseniana" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55831.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">300</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=androgenic%20alopecia&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=androgenic%20alopecia&page=2" rel="next">&rsaquo;</a></li> </ul> 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